Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to San Diego from $91

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Diego departing on 12/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
4:52 pm - 7:15 pmTYS-SAN
29h 23m1 stop
Frontier Logo
4:47 pm - 3:57 pmSAN-TYS
20h 10m1 stop
$182Frontier
Find Deal
Thu, Dec 4 - Sat, Dec 13
Frontier Logo
4:52 pm - 3:52 pmTYS-SAN
26h 00m2 stops
Frontier Logo
4:47 pm - 3:57 pmSAN-TYS
20h 10m1 stop
$232Frontier
Find Deal
Thu, Dec 4 - Sat, Dec 13
American Airlines Logo
7:54 am - 1:11 pmTYS-SAN
8h 17m1 stop
American Airlines Logo
10:45 pm - 9:42 amSAN-TYS
7h 57m1 stop
$277American Airlines
Find Deal
Sat, Jan 24 - Wed, Jan 28
American Airlines Logo
10:11 am - 4:54 pmTYS-SAN
9h 43m1 stop
American Airlines Logo
6:20 am - 10:10 pmSAN-TYS
12h 50m1 stop
$350American Airlines
Find Deal
Wed, Jan 7 - Sun, Jan 11
United Airlines Logo
4:25 pm - 8:42 pmTYS-SAN
7h 17m1 stop
United Airlines Logo
11:08 am - 11:44 pmSAN-TYS
9h 36m2 stops
$359United Airlines
Find Deal
Wed, Jan 7 - Sun, Jan 11
United Airlines Logo
6:45 am - 11:48 amTYS-SAN
8h 03m1 stop
United Airlines Logo
7:52 pm - 10:32 amSAN-TYS
11h 40m2 stops
$372United Airlines
Find Deal
Sat, Jan 24 - Wed, Jan 28
Delta Logo
12:30 pm - 6:03 pmTYS-SAN
8h 33m1 stop
Delta Logo
10:40 pm - 9:13 amSAN-TYS
7h 33m1 stop
$437Delta
Find Deal
Tue, Mar 10 - Wed, Mar 11
Delta Logo
12:47 pm - 6:00 pmTYS-SAN
8h 13m1 stop
Delta Logo
10:30 pm - 9:37 amSAN-TYS
8h 07m1 stop
$459Delta
Find Deal
Fri, Nov 7 - Tue, Nov 11
Alaska Airlines Logo
5:23 am - 9:49 amTYS-SAN
7h 26m1 stop
Alaska Airlines Logo
7:15 pm - 11:31 amSAN-TYS
13h 16m2 stops
$511Alaska Airlines
Find Deal
Thu, Jan 1 - Tue, Jan 6
Alaska Airlines Logo
12:18 pm - 12:07 amTYS-SAN
14h 49m2 stops
Alaska Airlines Logo
7:15 pm - 11:28 amSAN-TYS
13h 13m2 stops
$531Alaska Airlines
Find Deal
Fri, Dec 19 - Thu, Jan 1

Delta flights from Knoxville to San Diego

Our best Delta deals on Knoxville to San Diego flight tickets
Delta
Mar 10
TYS12:30 pmKnoxville McGhee Tyson
8h 33m
1 stop
SAN6:03 pmSan Diego
Mar 11
SAN10:40 pmSan Diego
7h 33m
1 stop
TYS9:13 amKnoxville McGhee Tyson
$437
Find similar
Delta
Nov 7
TYS12:47 pmKnoxville McGhee Tyson
8h 13m
1 stop
SAN6:00 pmSan Diego
Nov 11
SAN10:30 pmSan Diego
8h 07m
1 stop
TYS9:37 amKnoxville McGhee Tyson
$459
Find similar
Delta
Oct 30
TYS3:48 pmKnoxville McGhee Tyson
8h 32m
1 stop
SAN9:20 pmSan Diego
Nov 3
SAN2:05 pmSan Diego
6h 41m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
$546
Find similar

United Airlines flights from Knoxville to San Diego

Our best United Airlines deals on Knoxville to San Diego flight tickets
United Airlines
Jan 7
TYS4:25 pmKnoxville McGhee Tyson
7h 17m
1 stop
SAN8:42 pmSan Diego
Jan 11
SAN11:08 amSan Diego
9h 36m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
$359
Find similar
United Airlines
Jan 24
TYS6:45 amKnoxville McGhee Tyson
8h 03m
1 stop
SAN11:48 amSan Diego
Jan 28
SAN7:52 pmSan Diego
11h 40m
2 stops
TYS10:32 amKnoxville McGhee Tyson
$372
Find similar
United Airlines
Jan 24
TYS6:45 amKnoxville McGhee Tyson
13h 43m
2 stops
SAN5:28 pmSan Diego
Jan 28
SAN6:30 amSan Diego
9h 57m
2 stops
TYS7:27 pmKnoxville McGhee Tyson
$377
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 12/4

4:52 pm-7:15 pm

1 stop29h 23m

San Diego

Sat 12/13

4:47 pm-3:57 pm

1 stop20h 10m

$182

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 12/4

4:52 pm-3:52 pm

2 stops26h 00m

San Diego

Sat 12/13

4:47 pm-3:57 pm

1 stop20h 10m

$232

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 1/24

7:54 am-1:11 pm

1 stop8h 17m

San Diego

Wed 1/28

10:45 pm-9:42 am

1 stop7h 57m

$277

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 1/7

10:11 am-4:54 pm

1 stop9h 43m

San Diego

Sun 1/11

6:20 am-10:10 pm

1 stop12h 50m

$350

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 1/7

4:25 pm-8:42 pm

1 stop7h 17m

San Diego

Sun 1/11

11:08 am-11:44 pm

2 stops9h 36m

$359

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 1/24

6:45 am-11:48 am

1 stop8h 03m

San Diego

Wed 1/28

7:52 pm-10:32 am

2 stops11h 40m

$372

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 3/10

12:30 pm-6:03 pm

1 stop8h 33m

San Diego

Wed 3/11

10:40 pm-9:13 am

1 stop7h 33m

$437

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 11/7

12:47 pm-6:00 pm

1 stop8h 13m

San Diego

Tue 11/11

10:30 pm-9:37 am

1 stop8h 07m

$459

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 1/1

5:23 am-9:49 am

1 stop7h 26m

San Diego

Tue 1/6

7:15 pm-11:31 am

2 stops13h 16m

$511

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 12/19

12:18 pm-12:07 am

2 stops14h 49m

San Diego

Thu 1/1

7:15 pm-11:28 am

2 stops13h 13m

$531

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Diego from

How to get the cheapest flight ticket from Knoxville to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of July, then departing from Knoxville during the month January is also very affordable. Most momondo users find prices during this month for around $316.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Knoxville to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $388. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $584. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the evening when flights can be purchased for as low as $346. Flights in the morning are often more expensive with an average ticket price of $413.

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $400 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Knoxville for as low as $344 on momondo.

How have Knoxville to San Diego flight prices changed over time?

As of October 2025, prices for Knoxville to San Diego flights are approximately 28% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Diego (TYS to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Diego

Direct flights

None
There are no direct flights from Knoxville to San Diego. There are no popular flight routes from Knoxville to San Diego.
Search flight deals

  • How far is Knoxville McGhee Tyson to San Diego by plane?

    There are 1898.9 mi between Knoxville McGhee Tyson and San Diego. A reasonable flight in good conditions will take 6h 54m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Diego?

Best airlines flying from Knoxville to San Diego

Compare and see reviews for airlines that fly from Knoxville to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $150Free CancellationRating
5.8
3,130 reviews
Search Frontier flights
United AirlinesPriceFrom $255Free CancellationRating
7.4
8,991 reviews
Search United Airlines flights
American AirlinesPriceFrom $258Free CancellationRating
7.2
11,024 reviews
Search American Airlines flights
DeltaPriceFrom $276Free CancellationRating
7.9
7,978 reviews
Search Delta flights
Alaska AirlinesPriceFrom $366Free CancellationRating
8.0
11,136 reviews
Search Alaska Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
La Mesa
Imperial Beach
Poway
San Ysidro
Borrego Springs
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to San Diego for you.

Can I find flights from Knoxville to San Diego with flexible booking policies on momondo?

Flights from Knoxville to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Diego?

Once you have performed a search for Knoxville to San Diego flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your San Diego trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 11/19
Wed 11/26
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States