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Cheap flights from Knoxville to San Diego from $148

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Diego departing on 12/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
4:23 pm - 11:59 pm
TYS
-
SAN
10h 36m1 stop
Frontier Logo
6:25 am - 7:23 pm
SAN
-
TYS
9h 58m1 stop
$182Frontier
Thu, Jan 8 - Thu, Jan 15
Multiple Airlines Logo
5:59 pm - 1:55 pm
TYS
-
SAN
22h 56m2 stops
Multiple Airlines Logo
1:35 pm - 6:39 pm
SAN
-
TYS
26h 04m1 stop
$258Multiple Airlines
Sat, Jan 10 - Wed, Jan 14
Frontier Logo
4:23 pm - 9:57 am
TYS
-
SAN
20h 34m2 stops
Frontier Logo
6:25 am - 7:23 pm
SAN
-
TYS
9h 58m1 stop
$268Frontier
Thu, Jan 8 - Thu, Jan 15
United Airlines Logo
4:55 pm - 9:56 pm
TYS
-
SAN
8h 01m1 stop
United Airlines Logo
7:00 am - 4:53 pm
SAN
-
TYS
6h 53m1 stop
$277United Airlines
Tue, Jan 13 - Tue, Jan 20
United Airlines Logo
11:10 am - 5:28 pm
TYS
-
SAN
9h 18m2 stops
United Airlines Logo
1:51 pm - 11:44 pm
SAN
-
TYS
6h 53m1 stop
$282United Airlines
Tue, Jan 13 - Tue, Jan 20
United Airlines Logo
6:45 am - 11:48 am
TYS
-
SAN
8h 03m1 stop
United Airlines Logo
1:00 pm - 10:31 pm
SAN
-
TYS
6h 31m1 stop
$316United Airlines
Thu, Jan 15 - Sat, Jan 17
United Airlines Logo
6:45 am - 11:48 am
TYS
-
SAN
8h 03m1 stop
United Airlines Logo
11:08 am - 10:31 pm
SAN
-
TYS
8h 23m2 stops
$321United Airlines
Thu, Jan 15 - Sat, Jan 17
American Airlines Logo
4:44 pm - 10:26 pm
TYS
-
SAN
8h 42m1 stop
American Airlines Logo
7:10 am - 5:42 pm
SAN
-
TYS
7h 32m1 stop
$349American Airlines
Sat, Jan 24 - Wed, Jan 28
American Airlines Logo
6:51 pm - 10:50 pm
TYS
-
SAN
6h 59m1 stop
American Airlines Logo
10:45 pm - 9:45 am
SAN
-
TYS
8h 00m1 stop
$354American Airlines
Wed, Feb 4 - Sun, Feb 8
United Airlines Logo
11:07 am - 8:42 pm
TYS
-
SAN
12h 35m2 stops
United Airlines Logo
1:51 pm - 11:44 pm
SAN
-
TYS
6h 53m1 stop
$372United Airlines
Sat, Jan 24 - Wed, Jan 28

Frontier flights from Knoxville to San Diego

Our best Frontier deals on Knoxville to San Diego flight tickets
Frontier
Jan 8
TYS4:23 pmKnoxville McGhee Tyson
10h 36m
1 stop
SAN11:59 pmSan Diego
Feb 19
SAN6:25 amSan Diego
7h 15m
1 stop
TYS4:40 pmKnoxville McGhee Tyson
$165
Find similar
Frontier
Jan 8
TYS4:23 pmKnoxville McGhee Tyson
10h 36m
1 stop
SAN11:59 pmSan Diego
Jan 15
SAN6:25 amSan Diego
9h 58m
1 stop
TYS7:23 pmKnoxville McGhee Tyson
$182
Find similar
Frontier
Jan 5
TYS4:46 pmKnoxville McGhee Tyson
10h 13m
1 stop
SAN11:59 pmSan Diego
Feb 26
SAN6:25 amSan Diego
7h 15m
1 stop
TYS4:40 pmKnoxville McGhee Tyson
$186
Find similar

Delta flights from Knoxville to San Diego

Our best Delta deals on Knoxville to San Diego flight tickets
Delta
Jan 10
TYS5:40 amKnoxville McGhee Tyson
9h 23m
1 stop
SAN12:03 pmSan Diego
Feb 28
SAN2:15 pmSan Diego
6h 37m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
$277
Find similar
Delta
Jan 15
TYS5:40 amKnoxville McGhee Tyson
7h 18m
1 stop
SAN9:58 amSan Diego
Feb 24
SAN2:15 pmSan Diego
6h 37m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
$318
Find similar
Delta
Jan 8
TYS5:40 amKnoxville McGhee Tyson
7h 18m
1 stop
SAN9:58 amSan Diego
Feb 24
SAN2:15 pmSan Diego
6h 37m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
$354
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 1/8

4:23 pm-11:59 pm

1 stop10h 36m

San Diego

Thu 1/15

6:25 am-7:23 pm

1 stop9h 58m

$182

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 1/10

5:59 pm-1:55 pm

2 stops22h 56m

San Diego

Wed 1/14

1:35 pm-6:39 pm

1 stop26h 04m

$258

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 1/8

4:23 pm-9:57 am

2 stops20h 34m

San Diego

Thu 1/15

6:25 am-7:23 pm

1 stop9h 58m

$268

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 1/13

4:55 pm-9:56 pm

1 stop8h 01m

San Diego

Tue 1/20

7:00 am-4:53 pm

1 stop6h 53m

$277

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 1/13

11:10 am-5:28 pm

2 stops9h 18m

San Diego

Tue 1/20

1:51 pm-11:44 pm

1 stop6h 53m

$282

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 1/15

6:45 am-11:48 am

1 stop8h 03m

San Diego

Sat 1/17

1:00 pm-10:31 pm

1 stop6h 31m

$316

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 1/15

6:45 am-11:48 am

1 stop8h 03m

San Diego

Sat 1/17

11:08 am-10:31 pm

2 stops8h 23m

$321

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 1/24

4:44 pm-10:26 pm

1 stop8h 42m

San Diego

Wed 1/28

7:10 am-5:42 pm

1 stop7h 32m

$349

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 2/4

6:51 pm-10:50 pm

1 stop6h 59m

San Diego

Sun 2/8

10:45 pm-9:45 am

1 stop8h 00m

$354

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 1/24

11:07 am-8:42 pm

2 stops12h 35m

San Diego

Wed 1/28

1:51 pm-11:44 pm

1 stop6h 53m

$372

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Knoxville to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of July, then departing from Knoxville during the month February is also very affordable. Most momondo users find prices during this month for around $338.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Knoxville to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $388. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $584. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the evening when flights can be purchased for as low as $346. Flights in the morning are often more expensive with an average ticket price of $413.

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $420 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Knoxville for as low as $343 on momondo.

How have Knoxville to San Diego flight prices changed over time?

As of December 2025, prices for Knoxville to San Diego flights are approximately 67% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Diego (TYS to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Diego

Fastest flight time

6h 56m

Direct flights

None
The fastest flight from Knoxville to San Diego takes 6h 56m
There are no direct flights from Knoxville to San Diego. There are no popular flight routes from Knoxville to San Diego.
Search flight deals

  • How far is Knoxville McGhee Tyson to San Diego by plane?

    There are 1898.9 mi between Knoxville McGhee Tyson and San Diego. A reasonable flight in good conditions will take 6h 56m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Diego?

Best airlines flying from Knoxville to San Diego

Compare and see reviews for airlines that fly from Knoxville to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $150Free CancellationRating
5.8
3,084 reviews
Search Frontier flights
United AirlinesPriceFrom $258Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights
American AirlinesPriceFrom $258Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
DeltaPriceFrom $276Free CancellationRating
7.9
8,007 reviews
Search Delta flights
Alaska AirlinesPriceFrom $366Free CancellationRating
8.0
11,432 reviews
Search Alaska Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Imperial Beach
Poway
La Mesa
Borrego Springs
San Ysidro
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to San Diego for you.

Can I find flights from Knoxville to San Diego with flexible booking policies on momondo?

Flights from Knoxville to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Diego?

Once you have performed a search for Knoxville to San Diego flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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