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Cheap flights from Knoxville to San Diego from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Diego departing on 5/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:32 pm - 8:42 am
TYS
-
SAN
15h 10m
1 stop
Frontier Logo
9:37 am - 7:33 pm
SAN
-
TYS
6h 56m
1 stop
$242Frontier
Fri, May 8 - Mon, May 11
Frontier Logo
8:32 pm - 8:42 am
TYS
-
SAN
15h 10m
1 stop
Frontier Logo
9:37 am - 7:33 pm
SAN
-
TYS
6h 56m
1 stop
$261Frontier
Fri, May 8 - Mon, May 11
Multiple Airlines Logo
8:00 am - 7:46 am
TYS
-
SAN
26h 46m
1 stop
Multiple Airlines Logo
7:15 am - 3:41 pm
SAN
-
TYS
29h 26m
2 stops
$276Multiple Airlines
Sun, Apr 26 - Sat, May 2
Multiple Airlines Logo
8:00 am - 7:46 am
TYS
-
SAN
26h 46m
1 stop
Multiple Airlines Logo
11:42 am - 3:33 pm
SAN
-
TYS
24h 51m
1 stop
$290Multiple Airlines
Sun, Apr 26 - Sat, May 2
Frontier Logo
8:08 pm - 11:55 pm
TYS
-
SAN
6h 47m
1 stop
Frontier Logo
11:16 am - 7:13 pm
SAN
-
TYS
28h 57m
1 stop
$301Frontier
Wed, Aug 12 - Tue, Aug 18
American Airlines Logo
5:00 am - 11:08 am
TYS
-
SAN
9h 08m
1 stop
American Airlines Logo
6:15 am - 3:19 pm
SAN
-
TYS
6h 04m
1 stop
$317American Airlines
Tue, Apr 14 - Sat, Apr 18
Southwest Logo
5:50 pm - 9:20 pm
TYS
-
SAN
6h 30m
1 stop
Southwest Logo
7:35 am - 6:30 pm
SAN
-
TYS
7h 55m
2 stops
$322Southwest
Tue, Apr 21 - Sat, May 2
Frontier Logo
4:28 pm - 11:59 pm
TYS
-
SAN
10h 31m
1 stop
Frontier Logo
6:25 am - 3:33 pm
SAN
-
TYS
6h 08m
1 stop
$326Frontier
Thu, Apr 23 - Sun, Apr 26
United Airlines Logo
4:56 pm - 8:46 pm
TYS
-
SAN
6h 50m
1 stop
United Airlines Logo
6:40 am - 4:51 pm
SAN
-
TYS
7h 11m
1 stop
$327United Airlines
Wed, May 27 - Sat, May 30
Frontier Logo
4:20 pm - 8:26 pm
TYS
-
SAN
7h 06m
1 stop
Frontier Logo
9:28 pm - 3:28 pm
SAN
-
TYS
15h 00m
1 stop
$329Frontier
Fri, Apr 3 - Sun, Apr 5

Frontier flights from Knoxville to San Diego

Our best Frontier deals on Knoxville to San Diego flight tickets
Frontier
May 8
TYS8:32 pmKnoxville McGhee Tyson
15h 10m
1 stop
SAN8:42 amSan Diego
May 11
SAN9:37 amSan Diego
6h 56m
1 stop
TYS7:33 pmKnoxville McGhee Tyson
$242
Frontier
May 8
TYS8:32 pmKnoxville McGhee Tyson
15h 10m
1 stop
SAN8:42 amSan Diego
May 11
SAN9:37 amSan Diego
6h 56m
1 stop
TYS7:33 pmKnoxville McGhee Tyson
$261
Frontier
Aug 12
TYS8:08 pmKnoxville McGhee Tyson
6h 47m
1 stop
SAN11:55 pmSan Diego
Aug 18
SAN11:16 amSan Diego
28h 57m
1 stop
TYS7:13 pmKnoxville McGhee Tyson
$301

Southwest flights from Knoxville to San Diego

Our best Southwest deals on Knoxville to San Diego flight tickets
Southwest
Apr 21
TYS5:50 pmKnoxville McGhee Tyson
6h 30m
1 stop
SAN9:20 pmSan Diego
May 2
SAN7:35 amSan Diego
7h 55m
2 stops
TYS6:30 pmKnoxville McGhee Tyson
$322
Southwest
May 2
TYS12:20 pmKnoxville McGhee Tyson
10h 50m
2 stops
SAN8:10 pmSan Diego
May 5
SAN7:50 amSan Diego
8h 50m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
$400
Southwest
Mar 31
TYS2:25 pmKnoxville McGhee Tyson
9h 45m
2 stops
SAN9:10 pmSan Diego
Apr 7
SAN7:25 amSan Diego
9h 15m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
$520

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 19, 2026.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 5/8

8:32 pm-8:42 am

1 stop15h 10m

San Diego

Mon 5/11

9:37 am-7:33 pm

1 stop6h 56m

$242

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 5/8

8:32 pm-8:42 am

1 stop15h 10m

San Diego

Mon 5/11

9:37 am-7:33 pm

1 stop6h 56m

$261

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sun 4/26

8:00 am-7:46 am

1 stop26h 46m

San Diego

Sat 5/2

7:15 am-3:41 pm

2 stops29h 26m

$276

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sun 4/26

8:00 am-7:46 am

1 stop26h 46m

San Diego

Sat 5/2

11:42 am-3:33 pm

1 stop24h 51m

$290

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 8/12

8:08 pm-11:55 pm

1 stop6h 47m

San Diego

Tue 8/18

11:16 am-7:13 pm

1 stop28h 57m

$301

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 4/14

5:00 am-11:08 am

1 stop9h 08m

San Diego

Sat 4/18

6:15 am-3:19 pm

1 stop6h 04m

$317

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 4/21

5:50 pm-9:20 pm

1 stop6h 30m

San Diego

Sat 5/2

7:35 am-6:30 pm

2 stops7h 55m

$322

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 4/23

4:28 pm-11:59 pm

1 stop10h 31m

San Diego

Sun 4/26

6:25 am-3:33 pm

1 stop6h 08m

$326
Quickest round-trip

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 5/27

4:56 pm-8:46 pm

1 stop6h 50m

San Diego

Sat 5/30

6:40 am-4:51 pm

1 stop7h 11m

$327

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 4/3

4:20 pm-8:26 pm

1 stop7h 06m

San Diego

Sun 4/5

9:28 pm-3:28 pm

1 stop15h 00m

$329

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Knoxville to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of July, then departing from Knoxville during the month February is also very affordable. Most momondo users find prices during this month for around $303.

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $404 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Knoxville for as low as $308 on momondo.

How have Knoxville to San Diego flight prices changed over time?

As of March 2026, prices for Knoxville to San Diego flights are approximately 35% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Diego (TYS to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Diego

Fastest flight time

7h 12m

Direct flights

None
The fastest flight from Knoxville to San Diego takes 7h 12m
There are no direct flights from Knoxville to San Diego. There are no popular flight routes from Knoxville to San Diego.
Search flight deals

  • How far is Knoxville McGhee Tyson to San Diego by plane?

    There are 1898.9 mi between Knoxville McGhee Tyson and San Diego. A reasonable flight in good conditions will take 7h 12m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Diego?

Best airlines flying from Knoxville to San Diego

Compare and see reviews for airlines that fly from Knoxville to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $139Free CancellationRating
5.7
3,024 reviews
Search Frontier flights
DeltaPriceFrom $218Free CancellationRating
7.9
8,296 reviews
Search Delta flights
United AirlinesPriceFrom $276Free CancellationRating
7.4
9,441 reviews
Search United Airlines flights
American AirlinesPriceFrom $276Free CancellationRating
7.1
11,475 reviews
Search American Airlines flights
Alaska AirlinesPriceFrom $366Free CancellationRating
7.9
12,072 reviews
Search Alaska Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
San Ysidro
Imperial Beach
La Mesa
Borrego Springs
Alpine
Santee
Lemon Grove

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to San Diego for you.

Can I find flights from Knoxville to San Diego with flexible booking policies on momondo?

Flights from Knoxville to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Diego?

Once you have performed a search for Knoxville to San Diego flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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