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Cheap flights from Knoxville to San Diego from $139

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Diego departing on 9/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Knoxville to San Diego (TYS-SAN)

Cheap round-trip flights

Logo
6:30 am - 12:01 amTYS-SAN
20h 31m1 stop
Logo
12:38 pm - 7:14 pmSAN-TYS
27h 36m1 stop
$263
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Thu, Dec 4 - Sun, Dec 14
Logo
6:30 am - 12:01 amTYS-SAN
20h 31m1 stop
Logo
4:52 pm - 7:14 pmSAN-TYS
23h 22m2 stops
$266
Find Deal
Thu, Dec 4 - Sun, Dec 14
American Airlines Logo
9:08 am - 1:36 pmTYS-SAN
7h 28m1 stop
American Airlines Logo
2:25 pm - 11:45 pmSAN-TYS
6h 20m1 stop
$277American Airlines
Find Deal
Sat, Jan 24 - Wed, Jan 28
United Airlines Logo
5:29 pm - 10:33 pmTYS-SAN
8h 04m1 stop
United Airlines Logo
11:08 am - 10:31 pmSAN-TYS
8h 23m2 stops
$282United Airlines
Find Deal
Sat, Jan 24 - Wed, Jan 28
American Airlines Logo
8:23 am - 2:11 pmTYS-SAN
8h 48m1 stop
American Airlines Logo
12:38 pm - 12:21 amSAN-TYS
8h 43m1 stop
$329American Airlines
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Sat, Sep 20 - Sat, Sep 27
United Airlines Logo
5:00 pm - 9:56 pmTYS-SAN
7h 56m1 stop
United Airlines Logo
9:00 am - 9:02 pmSAN-TYS
9h 02m2 stops
$333United Airlines
Find Deal
Sat, Jan 10 - Sat, Jan 17
Delta Logo
8:35 am - 12:28 pmTYS-SAN
6h 53m1 stop
Delta Logo
10:30 pm - 9:44 amSAN-TYS
8h 14m1 stop
$347Delta
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Fri, Sep 26 - Tue, Sep 30
Delta Logo
5:16 pm - 11:14 pmTYS-SAN
8h 58m1 stop
Delta Logo
10:20 pm - 11:04 amSAN-TYS
9h 44m1 stop
$388Delta
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Wed, Oct 8 - Fri, Oct 10
Alaska Airlines Logo
6:00 am - 8:53 pmTYS-SAN
17h 53m2 stops
Alaska Airlines Logo
8:00 am - 12:23 amSAN-TYS
13h 23m2 stops
$429Alaska Airlines
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Sat, Oct 18 - Wed, Oct 22
Alaska Airlines Logo
5:10 am - 7:12 pmTYS-SAN
17h 02m2 stops
Alaska Airlines Logo
7:21 am - 5:28 pmSAN-TYS
7h 07m1 stop
$449Alaska Airlines
Find Deal
Thu, Nov 6 - Sat, Nov 15

American Airlines flights from Knoxville to San Diego

Our best American Airlines deals on Knoxville to San Diego flight tickets
American Airlines
Jan 24
TYS9:08 amKnoxville McGhee Tyson
7h 28m
1 stop
SAN1:36 pmSan Diego
Jan 28
SAN2:25 pmSan Diego
6h 20m
1 stop
TYS11:45 pmKnoxville McGhee Tyson
$277
Find similar
American Airlines
Sep 20
TYS8:23 amKnoxville McGhee Tyson
8h 48m
1 stop
SAN2:11 pmSan Diego
Sep 27
SAN12:38 pmSan Diego
8h 43m
1 stop
TYS12:21 amKnoxville McGhee Tyson
$329
Find similar
American Airlines
Sep 24
TYS2:07 pmKnoxville McGhee Tyson
6h 56m
1 stop
SAN6:03 pmSan Diego
Oct 30
SAN1:16 pmSan Diego
6h 54m
1 stop
TYS11:10 pmKnoxville McGhee Tyson
$354
Find similar

United Airlines flights from Knoxville to San Diego

Our best United Airlines deals on Knoxville to San Diego flight tickets
United Airlines
Jan 24
TYS5:29 pmKnoxville McGhee Tyson
8h 04m
1 stop
SAN10:33 pmSan Diego
Jan 28
SAN11:08 amSan Diego
8h 23m
2 stops
TYS10:31 pmKnoxville McGhee Tyson
$282
Find similar
United Airlines
Jan 10
TYS5:00 pmKnoxville McGhee Tyson
7h 56m
1 stop
SAN9:56 pmSan Diego
Jan 17
SAN9:00 amSan Diego
9h 02m
2 stops
TYS9:02 pmKnoxville McGhee Tyson
$333
Find similar
United Airlines
Sep 20
TYS7:00 amKnoxville McGhee Tyson
8h 57m
2 stops
SAN12:57 pmSan Diego
Sep 27
SAN10:15 amSan Diego
6h 37m
1 stop
TYS7:52 pmKnoxville McGhee Tyson
$334
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 25, 2025.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 12/4

6:30 am-12:01 am

1 stop20h 31m

San Diego

Sun 12/14

12:38 pm-7:14 pm

1 stop27h 36m

$263

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 12/4

6:30 am-12:01 am

1 stop20h 31m

San Diego

Sun 12/14

4:52 pm-7:14 pm

2 stops23h 22m

$266

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 1/24

9:08 am-1:36 pm

1 stop7h 28m

San Diego

Wed 1/28

2:25 pm-11:45 pm

1 stop6h 20m

$277

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 1/24

5:29 pm-10:33 pm

1 stop8h 04m

San Diego

Wed 1/28

11:08 am-10:31 pm

2 stops8h 23m

$282

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 9/20

8:23 am-2:11 pm

1 stop8h 48m

San Diego

Sat 9/27

12:38 pm-12:21 am

1 stop8h 43m

$329

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 1/10

5:00 pm-9:56 pm

1 stop7h 56m

San Diego

Sat 1/17

9:00 am-9:02 pm

2 stops9h 02m

$333

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 9/26

8:35 am-12:28 pm

1 stop6h 53m

San Diego

Tue 9/30

10:30 pm-9:44 am

1 stop8h 14m

$347

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 10/8

5:16 pm-11:14 pm

1 stop8h 58m

San Diego

Fri 10/10

10:20 pm-11:04 am

1 stop9h 44m

$388

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 10/18

6:00 am-8:53 pm

2 stops17h 53m

San Diego

Wed 10/22

8:00 am-12:23 am

2 stops13h 23m

$429

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 11/6

5:10 am-7:12 pm

2 stops17h 02m

San Diego

Sat 11/15

7:21 am-5:28 pm

1 stop7h 07m

$449

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Knoxville to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of January, then departing from Knoxville during the month July is also very affordable. Most momondo users find prices during this month for around $288.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Knoxville to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $388. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $584. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the evening when flights can be purchased for as low as $346. Flights in the morning are often more expensive with an average ticket price of $413.

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $400 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Knoxville for as low as $322 on momondo.

How have Knoxville to San Diego flight prices changed over time?

As of August 2025, prices for Knoxville to San Diego flights are approximately 3% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Diego (TYS to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Diego

Direct flights

None
There are no direct flights from Knoxville to San Diego. There are no popular flight routes from Knoxville to San Diego.
Search flight deals

  • How far is Knoxville McGhee Tyson to San Diego by plane?

    There are 1898.9 mi between Knoxville McGhee Tyson and San Diego. A reasonable flight in good conditions will take 6h 13m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Diego?

Best airlines flying from Knoxville to San Diego

Compare and see reviews for airlines that fly from Knoxville to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $139Free CancellationRating
5.8
3,201 reviews
Search Frontier flights
United AirlinesPriceFrom $258Free CancellationRating
7.4
8,940 reviews
Search United Airlines flights
American AirlinesPriceFrom $258Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $276Free CancellationRating
7.9
7,981 reviews
Search Delta flights
Alaska AirlinesPriceFrom $366Free CancellationRating
8.0
10,000 reviews
Search Alaska Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
La Mesa
National City
Imperial Beach
Poway
San Ysidro
Borrego Springs
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to San Diego for you.

Can I find flights from Knoxville to San Diego with flexible booking policies on momondo?

Flights from Knoxville to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Diego?

Once you have performed a search for Knoxville to San Diego flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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