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Cheap flights from Knoxville to San Diego from $138

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:00 am - 11:51 pmTYS  Knoxville McGhee Tyson-SAN San Diego
19h 51m1 stop Denver Intl
Multiple Airlines Logo
9:03 pm - 9:14 pmSAN  San Diego-TYS Knoxville McGhee Tyson
21h 11m1 stop Las Vegas Harry Reid Intl
$272Multiple Airlines
Thu, Sep 24 - Thu, Oct 1
Multiple Airlines Logo
6:30 am - 4:08 pmTYS  Knoxville McGhee Tyson-SAN San Diego
12h 38m1 stop Denver Intl
Multiple Airlines Logo
8:32 pm - 9:49 pmSAN  San Diego-TYS Knoxville McGhee Tyson
22h 17m1 stop Las Vegas Harry Reid Intl
$279Multiple Airlines
Sun, Oct 25 - Thu, Oct 29
American Airlines Logo
5:35 pm - 9:48 pmTYS  Knoxville McGhee Tyson-SAN San Diego
7h 13m1 stop Dallas/Fort Worth
American Airlines Logo
1:50 pm - 11:22 pmSAN  San Diego-TYS Knoxville McGhee Tyson
6h 32m1 stop Dallas/Fort Worth
$363American Airlines
Sat, Sep 19 - Sat, Sep 26
American Airlines Logo
3:21 pm - 8:01 pmTYS  Knoxville McGhee Tyson-SAN San Diego
7h 40m1 stop Dallas/Fort Worth
American Airlines Logo
1:50 pm - 11:22 pmSAN  San Diego-TYS Knoxville McGhee Tyson
6h 32m1 stop Dallas/Fort Worth
$363American Airlines
Sat, Sep 26 - Wed, Sep 30
Delta Logo
4:01 pm - 9:20 pmTYS  Knoxville McGhee Tyson-SAN San Diego
8h 19m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:50 pm - 10:01 amSAN  San Diego-TYS Knoxville McGhee Tyson
9h 11m1 stop Atlanta Hartsfield-Jackson
$363Delta
Sat, Dec 12 - Tue, Dec 15
Delta Logo
6:13 pm - 10:54 pmTYS  Knoxville McGhee Tyson-SAN San Diego
7h 41m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:20 pm - 10:17 amSAN  San Diego-TYS Knoxville McGhee Tyson
8h 57m1 stop Detroit Metropolitan Wayne County
$363Delta
Thu, Sep 24 - Mon, Oct 5
United Airlines Logo
4:53 pm - 8:39 pmTYS  Knoxville McGhee Tyson-SAN San Diego
6h 46m1 stop Denver Intl
United Airlines Logo
9:45 pm - 10:37 amSAN  San Diego-TYS Knoxville McGhee Tyson
9h 52m1 stop Washington, D.C. Dulles Intl
$363United Airlines
Tue, Oct 6 - Tue, Oct 13
United Airlines Logo
4:53 pm - 8:39 pmTYS  Knoxville McGhee Tyson-SAN San Diego
6h 46m1 stop Denver Intl
United Airlines Logo
10:30 pm - 9:45 amSAN  San Diego-TYS Knoxville McGhee Tyson
8h 15m1 stop Chicago O'Hare Intl
$363United Airlines
Tue, Oct 6 - Wed, Oct 7
Southwest Logo
7:05 am - 1:30 pmTYS  Knoxville McGhee Tyson-SAN San Diego
9h 25m2 stops Nashville Intl Denver Intl
Southwest Logo
6:35 am - 3:30 pmSAN  San Diego-TYS Knoxville McGhee Tyson
5h 55m1 stop Denver Intl
$368Southwest
Wed, Dec 9 - Tue, Dec 15
Southwest Logo
7:25 pm - 12:30 amTYS  Knoxville McGhee Tyson-SAN San Diego
8h 05m1 stop Nashville Intl
Southwest Logo
7:55 am - 6:50 pmSAN  San Diego-TYS Knoxville McGhee Tyson
7h 55m2 stops Phoenix Sky Harbor Intl Denver Intl
$368Southwest
Mon, Oct 26 - Thu, Oct 29

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Southwest flights from Knoxville to San Diego

Our best Southwest deals on Knoxville to San Diego flight tickets
Southwest
Oct 1
TYS7:25 pmKnoxville McGhee Tyson
8h 05m
1 stop
SAN12:30 amSan Diego
Oct 5
SAN10:40 pmSan Diego
10h 40m
1 stop
TYS12:20 pmKnoxville McGhee Tyson
$368
Southwest
Sep 22
TYS3:00 pmKnoxville McGhee Tyson
9h 05m
2 stops
SAN9:05 pmSan Diego
Sep 28
SAN6:40 amSan Diego
9h 00m
2 stops
TYS6:40 pmKnoxville McGhee Tyson
$373
Southwest
Sep 19
TYS6:50 amKnoxville McGhee Tyson
8h 15m
2 stops
SAN12:05 pmSan Diego
Sep 26
SAN5:10 pmSan Diego
14h 45m
2 stops
TYS10:55 amKnoxville McGhee Tyson
$379

United Airlines flights from Knoxville to San Diego

Our best United Airlines deals on Knoxville to San Diego flight tickets
United Airlines
Oct 6
TYS4:53 pmKnoxville McGhee Tyson
6h 46m
1 stop
SAN8:39 pmSan Diego
Oct 7
SAN10:30 pmSan Diego
8h 15m
1 stop
TYS9:45 amKnoxville McGhee Tyson
$387
United Airlines
Sep 9
TYS1:10 pmKnoxville McGhee Tyson
10h 19m
1 stop
SAN8:29 pmSan Diego
Sep 16
SAN6:30 amSan Diego
6h 24m
1 stop
TYS3:54 pmKnoxville McGhee Tyson
$491
United Airlines
Sep 6
TYS9:00 amKnoxville McGhee Tyson
8h 50m
1 stop
SAN2:50 pmSan Diego
Sep 19
SAN8:45 amSan Diego
12h 14m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
$492

momondo Fare Finder

 
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

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Price

Cheapest round-trip

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Thu 9/24

7:00 am-11:51 pm

1 stop19h 51m

San Diego

Thu 10/1

9:03 pm-9:14 pm

1 stop21h 11m

$272

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Sun 10/25

6:30 am-4:08 pm

1 stop12h 38m

San Diego

Thu 10/29

8:32 pm-9:49 pm

1 stop22h 17m

$279
Quickest round-trip

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Sat 9/19

5:35 pm-9:48 pm

1 stop7h 13m

San Diego

Sat 9/26

1:50 pm-11:22 pm

1 stop6h 32m

$363

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Sat 9/26

3:21 pm-8:01 pm

1 stop7h 40m

San Diego

Wed 9/30

1:50 pm-11:22 pm

1 stop6h 32m

$363

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Sat 12/12

4:01 pm-9:20 pm

1 stop8h 19m

San Diego

Tue 12/15

9:50 pm-10:01 am

1 stop9h 11m

$363

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Thu 9/24

6:13 pm-10:54 pm

1 stop7h 41m

San Diego

Mon 10/5

10:20 pm-10:17 am

1 stop8h 57m

$363

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Tue 10/6

4:53 pm-8:39 pm

1 stop6h 46m

San Diego

Tue 10/13

9:45 pm-10:37 am

1 stop9h 52m

$363

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Tue 10/6

4:53 pm-8:39 pm

1 stop6h 46m

San Diego

Wed 10/7

10:30 pm-9:45 am

1 stop8h 15m

$363

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Wed 12/9

7:05 am-1:30 pm

2 stops9h 25m

San Diego

Tue 12/15

6:35 am-3:30 pm

1 stop5h 55m

$368

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Mon 10/26

7:25 pm-12:30 am

1 stop8h 05m

San Diego

Thu 10/29

7:55 am-6:50 pm

2 stops7h 55m

$368

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Knoxville to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and San Diego?

Prices are currently low for flights on this route.

Typical prices usually range from $362 to $519.
The lowest price recently found on this route was $272.

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of February, then departing from Knoxville during the month August is also very affordable. Most momondo users find prices during this month for around $391.

How far in advance should I book a flight from Knoxville to San Diego?

You are more likely to see cheaper flights to San Diego from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $447 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Knoxville for as low as $262 on momondo.

How have Knoxville to San Diego flight prices changed over time?

As of August 2026, prices for Knoxville to San Diego flights are approximately 31% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Diego (TYS to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Diego

Best Price Found

$138

Fastest flight time

6h 15m

Direct flights

None
The best one-way flight to San Diego from Knoxville in the past 72 hours is $138. The best round-trip flight deal from Knoxville to San Diego found on momondo in the last 72 hours is $272.
The fastest flight from Knoxville to San Diego takes 6h 15m
There are no direct flights from Knoxville to San Diego. There are no popular flight routes from Knoxville to San Diego.
Search flight deals

Frequently asked questions about flying from Knoxville to San Diego

  • How far is Knoxville McGhee Tyson to San Diego by plane?

    There are 1898.9 mi between Knoxville McGhee Tyson and San Diego. A reasonable flight in good conditions will take 6h 15m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Diego?

Best airlines flying from Knoxville to San Diego

Compare and see reviews for airlines that fly from Knoxville to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $145Free CancellationRating
5.6
2,635 reviews
Search Frontier flights
Alaska AirlinesPriceFrom $218Free CancellationRating
7.9
12,865 reviews
Search Alaska Airlines flights
DeltaPriceFrom $250Free CancellationRating
7.8
8,538 reviews
Search Delta flights
United AirlinesPriceFrom $276Free CancellationRating
7.4
10,148 reviews
Search United Airlines flights
American AirlinesPriceFrom $277Free CancellationRating
7.1
12,021 reviews
Search American Airlines flights
SouthwestPriceFrom $354Free CancellationRating
8.0
4,199 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
Coronado
El Cajon
National City
La Mesa
Julian
Poway
San Ysidro
Imperial Beach
Santee
Alpine
Lemon Grove
Borrego Springs

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to San Diego for you.

Can I find flights from Knoxville to San Diego with flexible booking policies on momondo?

Flights from Knoxville to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Diego?

Once you have performed a search for Knoxville to San Diego flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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