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Cheap flights from Knoxville to San Diego from $140

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:32 pm - 11:56 pmTYS  Knoxville McGhee Tyson-SAN San Diego
9h 24m1 stop Dallas/Fort Worth
American Airlines Logo
7:15 am - 6:35 pmSAN  San Diego-TYS Knoxville McGhee Tyson
8h 20m1 stop Dallas/Fort Worth
$279American Airlines
Wed, Nov 11 - Sat, Nov 14
American Airlines Logo
7:30 pm - 11:56 pmTYS  Knoxville McGhee Tyson-SAN San Diego
7h 26m1 stop Dallas/Fort Worth
American Airlines Logo
2:18 pm - 11:32 pmSAN  San Diego-TYS Knoxville McGhee Tyson
6h 14m1 stop Dallas/Fort Worth
$279American Airlines
Wed, Nov 11 - Wed, Nov 18
Delta Logo
7:59 am - 12:12 pmTYS  Knoxville McGhee Tyson-SAN San Diego
7h 13m1 stop Minneapolis St Paul
Delta Logo
8:00 am - 8:14 pmSAN  San Diego-TYS Knoxville McGhee Tyson
9h 14m1 stop Atlanta Hartsfield-Jackson
$279Delta
Sat, Dec 12 - Tue, Dec 15
Delta Logo
7:10 am - 2:28 pmTYS  Knoxville McGhee Tyson-SAN San Diego
10h 18m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:20 am - 3:13 pmSAN  San Diego-TYS Knoxville McGhee Tyson
5h 53m1 stop Atlanta Hartsfield-Jackson
$279Delta
Sat, Dec 12 - Tue, Dec 15
United Airlines Logo
11:53 am - 4:09 pmTYS  Knoxville McGhee Tyson-SAN San Diego
7h 16m1 stop Houston George Bush Intcntl
United Airlines Logo
6:50 am - 4:54 pmSAN  San Diego-TYS Knoxville McGhee Tyson
7h 04m1 stop Chicago O'Hare Intl
$279United Airlines
Sat, Jan 23 - Wed, Jan 27
United Airlines Logo
9:45 am - 3:18 pmTYS  Knoxville McGhee Tyson-SAN San Diego
8h 33m1 stop Washington, D.C. Dulles Intl
United Airlines Logo
10:30 am - 8:47 pmSAN  San Diego-TYS Knoxville McGhee Tyson
7h 17m1 stop Chicago O'Hare Intl
$279United Airlines
Tue, Dec 8 - Sat, Dec 12
Southwest Logo
7:05 am - 1:30 pmTYS  Knoxville McGhee Tyson-SAN San Diego
9h 25m2 stops Nashville Intl Denver Intl
Southwest Logo
10:35 pm - 9:50 amSAN  San Diego-TYS Knoxville McGhee Tyson
8h 15m1 stop Nashville Intl
$284Southwest
Wed, Nov 18 - Wed, Nov 25
Southwest Logo
7:05 am - 1:40 pmTYS  Knoxville McGhee Tyson-SAN San Diego
9h 35m2 stops Nashville Intl Austin Bergstrom
Southwest Logo
6:15 am - 7:45 pmSAN  San Diego-TYS Knoxville McGhee Tyson
10h 30m1 stop Baltimore/Washington
$284Southwest
Tue, Dec 8 - Sat, Dec 12
Multiple Airlines Logo
4:06 pm - 8:02 amTYS  Knoxville McGhee Tyson-SAN San Diego
42h 56m2 stops Orlando Sanford Intl Las Vegas Harry Reid Intl
Multiple Airlines Logo
7:06 pm - 10:32 pmSAN  San Diego-TYS Knoxville McGhee Tyson
24h 26m1 stop Phoenix Sky Harbor Intl
$409Multiple Airlines
Sat, Dec 5 - Sat, Dec 12
Multiple Airlines Logo
6:30 am - 11:57 pmTYS  Knoxville McGhee Tyson-SAN San Diego
20h 27m1 stop Denver Intl
Multiple Airlines Logo
1:02 pm - 11:29 pmSAN  San Diego-TYS Knoxville McGhee Tyson
31h 27m2 stops Phoenix Sky Harbor Intl Orlando
$414Multiple Airlines
Thu, Nov 12 - Sun, Nov 22

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Southwest flights from Knoxville to San Diego

Our best Southwest deals on Knoxville to San Diego flight tickets
Southwest
Dec 12
TYS7:10 amKnoxville McGhee Tyson
10h 15m
2 stops
SAN2:25 pmSan Diego
Dec 16
SAN6:30 amSan Diego
10h 20m
2 stops
TYS7:50 pmKnoxville McGhee Tyson
$289
Southwest
Dec 8
TYS1:00 pmKnoxville McGhee Tyson
8h 55m
1 stop
SAN6:55 pmSan Diego
Dec 13
SAN10:35 pmSan Diego
10h 45m
1 stop
TYS12:20 pmKnoxville McGhee Tyson
$318
Southwest
Dec 8
TYS7:05 amKnoxville McGhee Tyson
7h 45m
2 stops
SAN11:50 amSan Diego
Dec 13
SAN6:30 amSan Diego
12h 15m
1 stop
TYS9:45 pmKnoxville McGhee Tyson
$324

Delta flights from Knoxville to San Diego

Our best Delta deals on Knoxville to San Diego flight tickets
Delta
Dec 12
TYS4:01 pmKnoxville McGhee Tyson
6h 58m
1 stop
SAN7:59 pmSan Diego
Dec 16
SAN12:31 pmSan Diego
7h 53m
1 stop
TYS11:24 pmKnoxville McGhee Tyson
$279
Delta
Nov 11
TYS5:40 amKnoxville McGhee Tyson
7h 09m
1 stop
SAN9:49 amSan Diego
Nov 18
SAN11:39 amSan Diego
6h 50m
1 stop
TYS9:29 pmKnoxville McGhee Tyson
$313
Delta
Feb 1
TYS5:57 pmKnoxville McGhee Tyson
6h 44m
1 stop
SAN9:41 pmSan Diego
Feb 5
SAN6:15 amSan Diego
8h 58m
1 stop
TYS6:13 pmKnoxville McGhee Tyson
$317

momondo Fare Finder

 
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

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Price

Cheapest round-trip

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Wed 11/11

5:32 pm-11:56 pm

1 stop9h 24m

San Diego

Sat 11/14

7:15 am-6:35 pm

1 stop8h 20m

$279
Quickest round-trip

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Wed 11/11

7:30 pm-11:56 pm

1 stop7h 26m

San Diego

Wed 11/18

2:18 pm-11:32 pm

1 stop6h 14m

$279

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Sat 12/12

7:59 am-12:12 pm

1 stop7h 13m

San Diego

Tue 12/15

8:00 am-8:14 pm

1 stop9h 14m

$279

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Sat 12/12

7:10 am-2:28 pm

1 stop10h 18m

San Diego

Tue 12/15

6:20 am-3:13 pm

1 stop5h 53m

$279

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Sat 1/23

11:53 am-4:09 pm

1 stop7h 16m

San Diego

Wed 1/27

6:50 am-4:54 pm

1 stop7h 04m

$279

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Tue 12/8

9:45 am-3:18 pm

1 stop8h 33m

San Diego

Sat 12/12

10:30 am-8:47 pm

1 stop7h 17m

$279

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Wed 11/18

7:05 am-1:30 pm

2 stops9h 25m

San Diego

Wed 11/25

10:35 pm-9:50 am

1 stop8h 15m

$284

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Tue 12/8

7:05 am-1:40 pm

2 stops9h 35m

San Diego

Sat 12/12

6:15 am-7:45 pm

1 stop10h 30m

$284

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Sat 12/5

4:06 pm-8:02 am

2 stops42h 56m

San Diego

Sat 12/12

7:06 pm-10:32 pm

1 stop24h 26m

$409

KnoxvilleSan Diego

TYS Knoxville McGhee Tyson - SAN San Diego

TYSSAN

Knoxville McGhee Tyson

Thu 11/12

6:30 am-11:57 pm

1 stop20h 27m

San Diego

Sun 11/22

1:02 pm-11:29 pm

2 stops31h 27m

$414

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Knoxville to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and San Diego?

Prices are currently low for flights on this route.

Typical prices usually range from $385 to $564.
The lowest price recently found on this route was $279.

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of February, then departing from Knoxville during the month August is also very affordable. Most momondo users find prices during this month for around $374.

How far in advance should I book a flight from Knoxville to San Diego?

You are more likely to see cheaper flights to San Diego from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $443 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Knoxville for as low as $336 on momondo.

How have Knoxville to San Diego flight prices changed over time?

As of October 2026, prices for Knoxville to San Diego flights are approximately 16% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Diego (TYS to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Diego

Best Price Found

$140

Fastest flight time

6h 46m

Direct flights

None
The best one-way flight to San Diego from Knoxville in the past 72 hours is $140. The best round-trip flight deal from Knoxville to San Diego found on momondo in the last 72 hours is $279.
The fastest flight from Knoxville to San Diego takes 6h 46m
There are no direct flights from Knoxville to San Diego. There are no popular flight routes from Knoxville to San Diego.
Search flight deals

Frequently asked questions about flying from Knoxville to San Diego

  • How far is Knoxville McGhee Tyson to San Diego by plane?

    There are 1898.9 mi between Knoxville McGhee Tyson and San Diego. A reasonable flight in good conditions will take 6h 46m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Diego?

Best airlines flying from Knoxville to San Diego

Compare and see reviews for airlines that fly from Knoxville to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $145Free CancellationRating
5.5
2,520 reviews
Search Frontier flights
Alaska AirlinesPriceFrom $218Free CancellationRating
7.9
13,106 reviews
Search Alaska Airlines flights
DeltaPriceFrom $250Free CancellationRating
7.8
8,655 reviews
Search Delta flights
United AirlinesPriceFrom $276Free CancellationRating
7.3
10,396 reviews
Search United Airlines flights
American AirlinesPriceFrom $316Free CancellationRating
7.0
12,183 reviews
Search American Airlines flights
SouthwestPriceFrom $362Free CancellationRating
7.9
4,208 reviews
Search Southwest flights

  • United Airlines Flights From Knoxville to San Diego

    Across 5 United Airlines flights from Knoxville to San Diego this week, the average price was $474, with the best United Airlines deals starting from $276 round-trip. 10,396 users have rated United Airlines on momondo, with an average score of 7.3/10.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
El Cajon
Coronado
National City
La Mesa
Julian
San Ysidro
Poway
Santee
Imperial Beach
Alpine
Lemon Grove
Borrego Springs

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to San Diego for you.

Can I find flights from Knoxville to San Diego with flexible booking policies on momondo?

Flights from Knoxville to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Diego?

Once you have performed a search for Knoxville to San Diego flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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