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Cheap flights from Knoxville to San Diego from $178

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Diego departing on 8/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:34 pm - 6:29 pm
TYS
-
SAN
6h 55m
1 stop
Multiple Airlines Logo
8:32 pm - 1:44 pm
SAN
-
TYS
14h 12m
1 stop
$266Multiple Airlines
Thu, Sep 10 - Sat, Sep 12
Multiple Airlines Logo
7:20 pm - 2:08 pm
TYS
-
SAN
45h 48m
2 stops
Multiple Airlines Logo
4:45 pm - 11:37 pm
SAN
-
TYS
27h 52m
1 stop
$269Multiple Airlines
Mon, Aug 3 - Wed, Aug 12
Multiple Airlines Logo
8:30 am - 11:51 pm
TYS
-
SAN
42h 21m
2 stops
Multiple Airlines Logo
3:45 pm - 1:44 pm
SAN
-
TYS
18h 59m
1 stop
$270Multiple Airlines
Fri, Aug 28 - Wed, Sep 2
Multiple Airlines Logo
7:20 pm - 2:08 pm
TYS
-
SAN
45h 48m
2 stops
Multiple Airlines Logo
4:45 pm - 11:37 pm
SAN
-
TYS
27h 52m
1 stop
$275Multiple Airlines
Mon, Aug 3 - Wed, Aug 12
Frontier Logo
8:19 pm - 9:05 am
TYS
-
SAN
15h 46m
1 stop
Frontier Logo
6:25 am - 7:24 pm
SAN
-
TYS
9h 59m
1 stop
$279Frontier
Wed, Jul 29 - Wed, Aug 5
Frontier Logo
8:19 pm - 9:05 am
TYS
-
SAN
15h 46m
1 stop
Frontier Logo
6:25 am - 7:24 pm
SAN
-
TYS
9h 59m
1 stop
$280Frontier
Mon, Aug 3 - Wed, Aug 12
Frontier Logo
8:19 pm - 9:05 am
TYS
-
SAN
15h 46m
1 stop
Frontier Logo
6:25 am - 7:24 pm
SAN
-
TYS
9h 59m
1 stop
$281Frontier
Mon, Aug 3 - Wed, Aug 12
Multiple Airlines Logo
6:30 am - 3:41 pm
TYS
-
SAN
12h 11m
1 stop
Multiple Airlines Logo
9:57 am - 8:56 pm
SAN
-
TYS
7h 59m
1 stop
$303Multiple Airlines
Sun, Nov 8 - Sun, Nov 15
Multiple Airlines Logo
2:34 pm - 6:29 pm
TYS
-
SAN
6h 55m
1 stop
Multiple Airlines Logo
9:57 am - 1:44 pm
SAN
-
TYS
24h 47m
2 stops
$307Multiple Airlines
Thu, Sep 10 - Sat, Sep 12
Multiple Airlines Logo
6:00 pm - 8:06 pm
TYS
-
SAN
29h 06m
2 stops
Multiple Airlines Logo
3:45 pm - 1:49 pm
SAN
-
TYS
19h 04m
1 stop
$317Multiple Airlines
Sat, Aug 15 - Sat, Aug 22

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American Airlines flights from Knoxville to San Diego

Our best American Airlines deals on Knoxville to San Diego flight tickets
American Airlines
Aug 6
TYS5:33 pmKnoxville McGhee Tyson
9h 26m
1 stop
SAN11:59 pmSan Diego
Aug 8
SAN10:20 pmSan Diego
9h 10m
1 stop
TYS10:30 amKnoxville McGhee Tyson
$365
American Airlines
Aug 27
TYS5:15 amKnoxville McGhee Tyson
7h 52m
1 stop
SAN10:07 amSan Diego
Aug 31
SAN12:47 pmSan Diego
7h 11m
1 stop
TYS10:58 pmKnoxville McGhee Tyson
$375
American Airlines
Aug 11
TYS5:15 amKnoxville McGhee Tyson
7h 52m
1 stop
SAN10:07 amSan Diego
Aug 15
SAN10:20 pmSan Diego
7h 18m
1 stop
TYS8:38 amKnoxville McGhee Tyson
$378

Southwest flights from Knoxville to San Diego

Our best Southwest deals on Knoxville to San Diego flight tickets
Southwest
Jul 29
TYS2:45 pmKnoxville McGhee Tyson
6h 35m
1 stop
SAN6:20 pmSan Diego
Aug 5
SAN8:05 amSan Diego
7h 50m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
$360
Southwest
Jul 29
TYS7:10 amKnoxville McGhee Tyson
9h 35m
2 stops
SAN1:45 pmSan Diego
Aug 5
SAN8:35 amSan Diego
7h 20m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
$366
Southwest
Aug 27
TYS8:25 amKnoxville McGhee Tyson
10h 50m
1 stop
SAN4:15 pmSan Diego
Aug 31
SAN6:40 amSan Diego
8h 55m
2 stops
TYS6:35 pmKnoxville McGhee Tyson
$380

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 4, 2026.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 9/10

2:34 pm-6:29 pm

1 stop6h 55m

San Diego

Sat 9/12

8:32 pm-1:44 pm

1 stop14h 12m

$266

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 8/3

7:20 pm-2:08 pm

2 stops45h 48m

San Diego

Wed 8/12

4:45 pm-11:37 pm

1 stop27h 52m

$269

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 8/28

8:30 am-11:51 pm

2 stops42h 21m

San Diego

Wed 9/2

3:45 pm-1:44 pm

1 stop18h 59m

$270

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 8/3

7:20 pm-2:08 pm

2 stops45h 48m

San Diego

Wed 8/12

4:45 pm-11:37 pm

1 stop27h 52m

$275

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 7/29

8:19 pm-9:05 am

1 stop15h 46m

San Diego

Wed 8/5

6:25 am-7:24 pm

1 stop9h 59m

$279

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 8/3

8:19 pm-9:05 am

1 stop15h 46m

San Diego

Wed 8/12

6:25 am-7:24 pm

1 stop9h 59m

$280

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 8/3

8:19 pm-9:05 am

1 stop15h 46m

San Diego

Wed 8/12

6:25 am-7:24 pm

1 stop9h 59m

$281
Quickest round-trip

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sun 11/8

6:30 am-3:41 pm

1 stop12h 11m

San Diego

Sun 11/15

9:57 am-8:56 pm

1 stop7h 59m

$303

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 9/10

2:34 pm-6:29 pm

1 stop6h 55m

San Diego

Sat 9/12

9:57 am-1:44 pm

2 stops24h 47m

$307

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 8/15

6:00 pm-8:06 pm

2 stops29h 06m

San Diego

Sat 8/22

3:45 pm-1:49 pm

1 stop19h 04m

$317

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Knoxville to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and San Diego?

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of February, then departing from Knoxville during the month September is also very affordable. Most momondo users find prices during this month for around $336.

How far in advance should I book a flight from Knoxville to San Diego?

You are more likely to see cheaper flights to San Diego from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $440 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Knoxville for as low as $324 on momondo.

How have Knoxville to San Diego flight prices changed over time?

As of July 2026, prices for Knoxville to San Diego flights are approximately 9% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Diego (TYS to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Diego

Fastest flight time

6h 32m

Direct flights

None
The fastest flight from Knoxville to San Diego takes 6h 32m
There are no direct flights from Knoxville to San Diego. There are no popular flight routes from Knoxville to San Diego.
Search flight deals

Frequently asked questions about flying from Knoxville to San Diego

  • How far is Knoxville McGhee Tyson to San Diego by plane?

    There are 1898.9 mi between Knoxville McGhee Tyson and San Diego. A reasonable flight in good conditions will take 6h 32m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Diego?

Best airlines flying from Knoxville to San Diego

Compare and see reviews for airlines that fly from Knoxville to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $125Free CancellationRating
5.6
2,847 reviews
Search Frontier flights
Alaska AirlinesPriceFrom $218Free CancellationRating
7.9
12,618 reviews
Search Alaska Airlines flights
DeltaPriceFrom $250Free CancellationRating
7.8
8,453 reviews
Search Delta flights
United AirlinesPriceFrom $276Free CancellationRating
7.4
9,930 reviews
Search United Airlines flights
American AirlinesPriceFrom $276Free CancellationRating
7.1
11,765 reviews
Search American Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
Coronado
El Cajon
Julian
National City
La Mesa
Poway
San Ysidro
Imperial Beach
Borrego Springs
Santee
Lemon Grove
Alpine

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to San Diego for you.

Can I find flights from Knoxville to San Diego with flexible booking policies on momondo?

Flights from Knoxville to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Diego?

Once you have performed a search for Knoxville to San Diego flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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