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Cheap flights from Knoxville to San Diego from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Diego departing on 2/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:13 pm - 9:41 pm
TYS
-
SAN
28h 28m
1 stop
Frontier Logo
8:35 am - 6:06 pm
SAN
-
TYS
6h 31m
1 stop
$209Frontier
Mon, Feb 23 - Fri, Feb 27
Frontier Logo
4:25 pm - 12:08 am
TYS
-
SAN
10h 43m
1 stop
Frontier Logo
6:30 am - 3:35 pm
SAN
-
TYS
6h 05m
1 stop
$235Frontier
Fri, Feb 6 - Mon, Feb 9
Frontier Logo
4:25 pm - 12:08 am
TYS
-
SAN
10h 43m
1 stop
Frontier Logo
6:30 am - 3:35 pm
SAN
-
TYS
30h 05m
1 stop
$250Frontier
Fri, Feb 6 - Sun, Feb 8
Multiple Airlines Logo
4:30 pm - 9:14 pm
TYS
-
SAN
7h 44m
1 stop
Multiple Airlines Logo
6:25 am - 5:52 pm
SAN
-
TYS
8h 27m
1 stop
$255Multiple Airlines
Mon, Feb 9 - Thu, Feb 12
Frontier Logo
4:30 pm - 12:08 am
TYS
-
SAN
10h 38m
1 stop
Frontier Logo
6:30 am - 3:30 pm
SAN
-
TYS
6h 00m
1 stop
$256Frontier
Mon, Feb 2 - Fri, Feb 6
United Airlines Logo
8:45 am - 3:00 pm
TYS
-
SAN
9h 15m
1 stop
United Airlines Logo
10:59 am - 8:37 pm
SAN
-
TYS
6h 38m
1 stop
$277United Airlines
Tue, Feb 24 - Tue, Mar 3
United Airlines Logo
9:40 am - 3:41 pm
TYS
-
SAN
9h 01m
1 stop
United Airlines Logo
11:05 am - 10:30 pm
SAN
-
TYS
8h 25m
2 stops
$282United Airlines
Tue, Feb 24 - Tue, Mar 3
American Airlines Logo
5:45 am - 12:08 pm
TYS
-
SAN
9h 23m
1 stop
American Airlines Logo
6:20 am - 4:31 pm
SAN
-
TYS
7h 11m
1 stop
$304American Airlines
Tue, Feb 17 - Tue, Feb 24
Southwest Logo
7:10 pm - 11:00 pm
TYS
-
SAN
6h 50m
1 stop
Southwest Logo
6:20 am - 9:10 pm
SAN
-
TYS
11h 50m
1 stop
$309Southwest
Sat, Mar 7 - Wed, Mar 11
Frontier Logo
4:30 pm - 12:08 am
TYS
-
SAN
10h 38m
1 stop
Frontier Logo
6:30 am - 3:30 pm
SAN
-
TYS
6h 00m
1 stop
$311Frontier
Mon, Feb 2 - Fri, Feb 6

Frontier flights from Knoxville to San Diego

Our best Frontier deals on Knoxville to San Diego flight tickets
Frontier
Feb 23
TYS8:13 pmKnoxville McGhee Tyson
28h 28m
1 stop
SAN9:41 pmSan Diego
Feb 27
SAN8:35 amSan Diego
6h 31m
1 stop
TYS6:06 pmKnoxville McGhee Tyson
$209
Frontier
Feb 6
TYS4:25 pmKnoxville McGhee Tyson
10h 43m
1 stop
SAN12:08 amSan Diego
Feb 9
SAN6:30 amSan Diego
6h 05m
1 stop
TYS3:35 pmKnoxville McGhee Tyson
$235
Frontier
Feb 6
TYS4:25 pmKnoxville McGhee Tyson
10h 43m
1 stop
SAN12:08 amSan Diego
Feb 8
SAN6:30 amSan Diego
30h 05m
1 stop
TYS3:35 pmKnoxville McGhee Tyson
$250

Delta flights from Knoxville to San Diego

Our best Delta deals on Knoxville to San Diego flight tickets
Delta
Apr 15
TYS11:02 amKnoxville McGhee Tyson
10h 17m
1 stop
SAN6:19 pmSan Diego
Apr 19
SAN10:10 pmSan Diego
9h 11m
1 stop
TYS10:21 amKnoxville McGhee Tyson
$354
Delta
Feb 10
TYS2:37 pmKnoxville McGhee Tyson
7h 14m
1 stop
SAN6:51 pmSan Diego
Feb 17
SAN10:20 pmSan Diego
7h 44m
1 stop
TYS9:04 amKnoxville McGhee Tyson
$376
Delta
Mar 9
TYS6:38 pmKnoxville McGhee Tyson
7h 31m
1 stop
SAN11:09 pmSan Diego
Mar 13
SAN10:10 pmSan Diego
9h 30m
1 stop
TYS10:40 amKnoxville McGhee Tyson
$405

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 2/23

8:13 pm-9:41 pm

1 stop28h 28m

San Diego

Fri 2/27

8:35 am-6:06 pm

1 stop6h 31m

$209

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 2/6

4:25 pm-12:08 am

1 stop10h 43m

San Diego

Mon 2/9

6:30 am-3:35 pm

1 stop6h 05m

$235

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 2/6

4:25 pm-12:08 am

1 stop10h 43m

San Diego

Sun 2/8

6:30 am-3:35 pm

1 stop30h 05m

$250

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 2/9

4:30 pm-9:14 pm

1 stop7h 44m

San Diego

Thu 2/12

6:25 am-5:52 pm

1 stop8h 27m

$255

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 2/2

4:30 pm-12:08 am

1 stop10h 38m

San Diego

Fri 2/6

6:30 am-3:30 pm

1 stop6h 00m

$256

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 2/24

8:45 am-3:00 pm

1 stop9h 15m

San Diego

Tue 3/3

10:59 am-8:37 pm

1 stop6h 38m

$277

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 2/24

9:40 am-3:41 pm

1 stop9h 01m

San Diego

Tue 3/3

11:05 am-10:30 pm

2 stops8h 25m

$282

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 2/17

5:45 am-12:08 pm

1 stop9h 23m

San Diego

Tue 2/24

6:20 am-4:31 pm

1 stop7h 11m

$304

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 3/7

7:10 pm-11:00 pm

1 stop6h 50m

San Diego

Wed 3/11

6:20 am-9:10 pm

1 stop11h 50m

$309

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 2/2

4:30 pm-12:08 am

1 stop10h 38m

San Diego

Fri 2/6

6:30 am-3:30 pm

1 stop6h 00m

$311

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Knoxville to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of July, then departing from Knoxville during the month February is also very affordable. Most momondo users find prices during this month for around $330.

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $411 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Knoxville for as low as $331 on momondo.

How have Knoxville to San Diego flight prices changed over time?

As of January 2026, prices for Knoxville to San Diego flights are approximately 83% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Diego (TYS to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Diego

Fastest flight time

7h 07m

Direct flights

None
The fastest flight from Knoxville to San Diego takes 7h 07m
There are no direct flights from Knoxville to San Diego. There are no popular flight routes from Knoxville to San Diego.
Search flight deals

  • How far is Knoxville McGhee Tyson to San Diego by plane?

    There are 1898.9 mi between Knoxville McGhee Tyson and San Diego. A reasonable flight in good conditions will take 7h 07m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Diego?

Best airlines flying from Knoxville to San Diego

Compare and see reviews for airlines that fly from Knoxville to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $82Free CancellationRating
5.7
3,056 reviews
Search Frontier flights
United AirlinesPriceFrom $255Free CancellationRating
7.4
9,207 reviews
Search United Airlines flights
American AirlinesPriceFrom $258Free CancellationRating
7.2
11,198 reviews
Search American Airlines flights
DeltaPriceFrom $276Free CancellationRating
7.9
8,121 reviews
Search Delta flights
Alaska AirlinesPriceFrom $366Free CancellationRating
8.0
11,799 reviews
Search Alaska Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
Poway
National City
Imperial Beach
San Ysidro
Borrego Springs
La Mesa
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to San Diego for you.

Can I find flights from Knoxville to San Diego with flexible booking policies on momondo?

Flights from Knoxville to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Diego?

Once you have performed a search for Knoxville to San Diego flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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