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Cheap flights from Knoxville to San Diego from $116

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Diego departing on 7/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:32 pm - 8:42 am
TYS
-
SAN
15h 10m
1 stop
Frontier Logo
6:25 am - 7:37 pm
SAN
-
TYS
10h 12m
1 stop
$232Frontier
Mon, Jun 1 - Wed, Jun 10
Frontier Logo
8:32 pm - 8:42 am
TYS
-
SAN
15h 10m
1 stop
Frontier Logo
1:28 pm - 7:37 pm
SAN
-
TYS
27h 09m
1 stop
$247Frontier
Mon, Jun 1 - Tue, Jun 9
Frontier Logo
8:32 pm - 8:42 am
TYS
-
SAN
15h 10m
1 stop
Frontier Logo
6:25 am - 7:37 pm
SAN
-
TYS
10h 12m
1 stop
$260Frontier
Fri, Jun 19 - Mon, Jun 22
Frontier Logo
8:19 pm - 11:50 pm
TYS
-
SAN
6h 31m
1 stop
Frontier Logo
6:25 am - 7:33 pm
SAN
-
TYS
10h 08m
1 stop
$270Frontier
Fri, May 29 - Fri, Jun 5
Frontier Logo
8:32 pm - 8:42 am
TYS
-
SAN
15h 10m
1 stop
Frontier Logo
6:25 am - 7:33 pm
SAN
-
TYS
10h 08m
1 stop
$280Frontier
Mon, Jun 1 - Mon, Jun 8
Frontier Logo
8:32 pm - 9:09 am
TYS
-
SAN
15h 37m
1 stop
Frontier Logo
10:04 am - 7:37 pm
SAN
-
TYS
6h 33m
1 stop
$281Frontier
Mon, Jun 22 - Fri, Jun 26
Multiple Airlines Logo
6:00 am - 8:42 am
TYS
-
SAN
29h 42m
2 stops
Multiple Airlines Logo
1:28 pm - 7:37 pm
SAN
-
TYS
27h 09m
1 stop
$286Multiple Airlines
Mon, Jun 1 - Tue, Jun 9
Multiple Airlines Logo
7:00 am - 9:09 am
TYS
-
SAN
29h 09m
1 stop
Multiple Airlines Logo
9:53 pm - 12:03 pm
SAN
-
TYS
35h 10m
2 stops
$296Multiple Airlines
Sun, Jun 28 - Wed, Jul 8
Multiple Airlines Logo
2:46 pm - 8:48 am
TYS
-
SAN
21h 02m
1 stop
Multiple Airlines Logo
9:43 am - 11:59 am
SAN
-
TYS
47h 16m
2 stops
$305Multiple Airlines
Mon, Jun 8 - Wed, Jun 17
Multiple Airlines Logo
7:00 am - 8:42 am
TYS
-
SAN
28h 42m
1 stop
Multiple Airlines Logo
6:25 am - 11:59 am
SAN
-
TYS
26h 34m
2 stops
$306Multiple Airlines
Sun, Jun 7 - Sun, Jun 14

American Airlines flights from Knoxville to San Diego

Our best American Airlines deals on Knoxville to San Diego flight tickets
American Airlines
May 27
TYS3:40 pmKnoxville McGhee Tyson
9h 08m
1 stop
SAN9:48 pmSan Diego
May 29
SAN12:20 pmSan Diego
8h 36m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
$337
American Airlines
May 27
TYS6:20 pmKnoxville McGhee Tyson
8h 19m
1 stop
SAN11:39 pmSan Diego
May 28
SAN1:21 pmSan Diego
7h 26m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$357
American Airlines
Jun 3
TYS5:33 pmKnoxville McGhee Tyson
9h 26m
1 stop
SAN11:59 pmSan Diego
Jun 8
SAN10:45 pmSan Diego
9h 13m
1 stop
TYS10:58 amKnoxville McGhee Tyson
$369

United Airlines flights from Knoxville to San Diego

Our best United Airlines deals on Knoxville to San Diego flight tickets
United Airlines
Jun 2
TYS4:56 pmKnoxville McGhee Tyson
6h 50m
1 stop
SAN8:46 pmSan Diego
Jun 9
SAN6:15 amSan Diego
8h 52m
1 stop
TYS6:07 pmKnoxville McGhee Tyson
$340
United Airlines
May 19
TYS7:00 amKnoxville McGhee Tyson
13h 24m
2 stops
SAN5:24 pmSan Diego
Jun 19
SAN10:40 pmSan Diego
8h 03m
1 stop
TYS9:43 amKnoxville McGhee Tyson
$604
United Airlines
May 19
TYS7:00 amKnoxville McGhee Tyson
13h 24m
2 stops
SAN5:24 pmSan Diego
Jun 19
SAN10:40 pmSan Diego
8h 03m
1 stop
TYS9:43 amKnoxville McGhee Tyson
$609

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 8, 2026.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 6/1

8:32 pm-8:42 am

1 stop15h 10m

San Diego

Wed 6/10

6:25 am-7:37 pm

1 stop10h 12m

$232

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 6/1

8:32 pm-8:42 am

1 stop15h 10m

San Diego

Tue 6/9

1:28 pm-7:37 pm

1 stop27h 09m

$247

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 6/19

8:32 pm-8:42 am

1 stop15h 10m

San Diego

Mon 6/22

6:25 am-7:37 pm

1 stop10h 12m

$260
Quickest round-trip

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Fri 5/29

8:19 pm-11:50 pm

1 stop6h 31m

San Diego

Fri 6/5

6:25 am-7:33 pm

1 stop10h 08m

$270

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 6/1

8:32 pm-8:42 am

1 stop15h 10m

San Diego

Mon 6/8

6:25 am-7:33 pm

1 stop10h 08m

$280

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 6/22

8:32 pm-9:09 am

1 stop15h 37m

San Diego

Fri 6/26

10:04 am-7:37 pm

1 stop6h 33m

$281

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 6/1

6:00 am-8:42 am

2 stops29h 42m

San Diego

Tue 6/9

1:28 pm-7:37 pm

1 stop27h 09m

$286

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sun 6/28

7:00 am-9:09 am

1 stop29h 09m

San Diego

Wed 7/8

9:53 pm-12:03 pm

2 stops35h 10m

$296

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Mon 6/8

2:46 pm-8:48 am

1 stop21h 02m

San Diego

Wed 6/17

9:43 am-11:59 am

2 stops47h 16m

$305

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sun 6/7

7:00 am-8:42 am

1 stop28h 42m

San Diego

Sun 6/14

6:25 am-11:59 am

2 stops26h 34m

$306

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Knoxville to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and San Diego?

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of July, then departing from Knoxville during the month February is also very affordable. Most momondo users find prices during this month for around $303.

How far in advance should I book a flight from Knoxville to San Diego?

You are more likely to see cheaper flights to San Diego from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $410 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Knoxville for as low as $331 on momondo.

How have Knoxville to San Diego flight prices changed over time?

As of May 2026, prices for Knoxville to San Diego flights are approximately 61% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Diego (TYS to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Diego

Fastest flight time

6h 10m

Direct flights

None
The fastest flight from Knoxville to San Diego takes 6h 10m
There are no direct flights from Knoxville to San Diego. There are no popular flight routes from Knoxville to San Diego.
Search flight deals

Frequently asked questions about flying from Knoxville to San Diego

  • How far is Knoxville McGhee Tyson to San Diego by plane?

    There are 1898.9 mi between Knoxville McGhee Tyson and San Diego. A reasonable flight in good conditions will take 6h 10m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Diego Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Diego?

Best airlines flying from Knoxville to San Diego

Compare and see reviews for airlines that fly from Knoxville to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $125Free CancellationRating
5.6
2,963 reviews
Search Frontier flights
Alaska AirlinesPriceFrom $218Free CancellationRating
7.9
12,342 reviews
Search Alaska Airlines flights
United AirlinesPriceFrom $276Free CancellationRating
7.4
9,694 reviews
Search United Airlines flights
DeltaPriceFrom $276Free CancellationRating
7.9
8,456 reviews
Search Delta flights
American AirlinesPriceFrom $276Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
San Ysidro
La Mesa
Imperial Beach
Borrego Springs
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to San Diego for you.

Can I find flights from Knoxville to San Diego with flexible booking policies on momondo?

Flights from Knoxville to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Diego?

Once you have performed a search for Knoxville to San Diego flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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