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Cheap flights from Knoxville to Key West from $56

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Key West departing on 10/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Key West

Cheap round-trip flights

Allegiant Air Logo
12:55 pm - 3:06 pmTYS-EYW
2h 11mnonstop
Allegiant Air Logo
9:50 am - 12:05 pmEYW-TYS
2h 15mnonstop
$118Allegiant Air
Find Deal
Mon, Oct 13 - Mon, Oct 20
Allegiant Air Logo
12:55 pm - 3:06 pmTYS-EYW
2h 11mnonstop
Allegiant Air Logo
9:02 am - 11:17 amEYW-TYS
2h 15mnonstop
$145Allegiant Air
Find Deal
Mon, Oct 13 - Fri, Oct 17
Allegiant Air Logo
2:40 pm - 4:51 pmTYS-EYW
2h 11mnonstop
Allegiant Air Logo
5:41 pm - 7:56 pmEYW-TYS
2h 15mnonstop
$146Allegiant Air
Find Deal
Fri, Jan 9 - Mon, Jan 12
Allegiant Air Logo
11:32 am - 1:43 pmTYS-EYW
2h 11mnonstop
Allegiant Air Logo
8:45 pm - 11:00 pmEYW-TYS
2h 15mnonstop
$147Allegiant Air
Find Deal
Fri, Dec 19 - Wed, Dec 24
Allegiant Air Logo
10:08 pm - 2:40 pmTYS-EYW
16h 32m1 stop
Allegiant Air Logo
3:39 pm - 5:54 pmEYW-TYS
2h 15mnonstop
$165Allegiant Air
Find Deal
Sat, Oct 18 - Fri, Oct 24
Multiple Airlines Logo
11:08 am - 8:15 amTYS-EYW
21h 07m2 stops
Multiple Airlines Logo
3:39 pm - 5:54 pmEYW-TYS
2h 15mnonstop
$217Multiple Airlines
Find Deal
Sat, Oct 18 - Fri, Oct 24
Multiple Airlines Logo
12:55 pm - 3:06 pmTYS-EYW
2h 11mnonstop
Multiple Airlines Logo
9:57 am - 11:16 pmEYW-TYS
13h 19m2 stops
$222Multiple Airlines
Find Deal
Mon, Oct 13 - Mon, Oct 20
American Airlines Logo
5:03 pm - 11:07 pmTYS-EYW
6h 04m1 stop
American Airlines Logo
7:30 am - 2:00 pmEYW-TYS
6h 30m1 stop
$249American Airlines
Find Deal
Sat, Dec 13 - Wed, Dec 17
American Airlines Logo
4:31 pm - 9:50 pmTYS-EYW
5h 19m1 stop
American Airlines Logo
7:00 am - 2:00 pmEYW-TYS
7h 00m2 stops
$254American Airlines
Find Deal
Sat, Dec 13 - Wed, Dec 17
Delta Logo
5:44 am - 11:27 amTYS-EYW
5h 43m1 stop
Delta Logo
6:17 pm - 11:07 pmEYW-TYS
4h 50m1 stop
$294Delta
Find Deal
Mon, Oct 20 - Wed, Oct 29

American Airlines flights from Knoxville to Key West

Our best American Airlines deals on Knoxville to Key West flight tickets
American Airlines
Dec 13
TYS5:03 pmKnoxville McGhee Tyson
6h 04m
1 stop
EYW11:07 pmKey West
Dec 17
EYW7:30 amKey West
6h 30m
1 stop
TYS2:00 pmKnoxville McGhee Tyson
$249
Find similar
American Airlines
Dec 13
TYS4:31 pmKnoxville McGhee Tyson
5h 19m
1 stop
EYW9:50 pmKey West
Dec 17
EYW7:00 amKey West
7h 00m
2 stops
TYS2:00 pmKnoxville McGhee Tyson
$254
Find similar
American Airlines
Jan 9
TYS10:57 amKnoxville McGhee Tyson
4h 21m
1 stop
EYW3:18 pmKey West
Jan 12
EYW1:55 pmKey West
7h 40m
2 stops
TYS9:35 pmKnoxville McGhee Tyson
$279
Find similar

Allegiant Air flights from Knoxville to Key West

Our best Allegiant Air deals on Knoxville to Key West flight tickets
Allegiant Air
Oct 13
TYS12:55 pmKnoxville McGhee Tyson
2h 11m
EYW3:06 pmKey West
Oct 20
EYW9:50 amKey West
2h 15m
TYS12:05 pmKnoxville McGhee Tyson
$118
Find similar
Allegiant Air
Oct 13
TYS12:55 pmKnoxville McGhee Tyson
2h 11m
EYW3:06 pmKey West
Oct 17
EYW9:02 amKey West
2h 15m
TYS11:17 amKnoxville McGhee Tyson
$145
Find similar
Allegiant Air
Jan 9
TYS2:40 pmKnoxville McGhee Tyson
2h 11m
EYW4:51 pmKey West
Jan 12
EYW5:41 pmKey West
2h 15m
TYS7:56 pmKnoxville McGhee Tyson
$146
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Knoxville to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 10/13

12:55 pm-3:06 pm

Nonstop2h 11m

Key West

Mon 10/20

9:50 am-12:05 pm

Nonstop2h 15m

$118

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 10/13

12:55 pm-3:06 pm

Nonstop2h 11m

Key West

Fri 10/17

9:02 am-11:17 am

Nonstop2h 15m

$145

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 1/9

2:40 pm-4:51 pm

Nonstop2h 11m

Key West

Mon 1/12

5:41 pm-7:56 pm

Nonstop2h 15m

$146

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 12/19

11:32 am-1:43 pm

Nonstop2h 11m

Key West

Wed 12/24

8:45 pm-11:00 pm

Nonstop2h 15m

$147

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sat 10/18

10:08 pm-2:40 pm

1 stop16h 32m

Key West

Fri 10/24

3:39 pm-5:54 pm

Nonstop2h 15m

$165

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sat 10/18

11:08 am-8:15 am

2 stops21h 07m

Key West

Fri 10/24

3:39 pm-5:54 pm

Nonstop2h 15m

$217

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 10/13

12:55 pm-3:06 pm

Nonstop2h 11m

Key West

Mon 10/20

9:57 am-11:16 pm

2 stops13h 19m

$222

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sat 12/13

5:03 pm-11:07 pm

1 stop6h 04m

Key West

Wed 12/17

7:30 am-2:00 pm

1 stop6h 30m

$249

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sat 12/13

4:31 pm-9:50 pm

1 stop5h 19m

Key West

Wed 12/17

7:00 am-2:00 pm

2 stops7h 00m

$254

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 10/20

5:44 am-11:27 am

1 stop5h 43m

Key West

Wed 10/29

6:17 pm-11:07 pm

1 stop4h 50m

$294

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Knoxville to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, October is the cheapest month to fly from Knoxville to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $259. If you are unable to visit Key West during the month of October, then departing from Knoxville during the month June is also very affordable. Most momondo users find prices during this month for around $318.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Knoxville is on a Monday. momondo users have found tickets for Monday departures for as low as $140. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Knoxville to Key West for around $523.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is in the afternoon. momondo users have found flights departing from Knoxville to Key West in the afternoon for as low as $115. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the evening, with an average ticket price of $461. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Knoxville McGhee Tyson to Key West flight route?

Fly from Knoxville McGhee Tyson to Key West for the best Knoxville McGhee Tyson - Key West flight prices

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $361 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Knoxville for as low as $136 on momondo.

What cabin class options are available on Knoxville McGhee Tyson to Key West flights?

There is only 1 cabin class available to choose from on Knoxville McGhee Tyson to Key West flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Knoxville to Key West flights?

No. A direct flight is the cheapest option for a flight between Knoxville to Key West.

When to book flights from Knoxville to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Key West (TYS to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Key West

Best Price Found

$109

Fastest flight time

2h 11m

Direct flights

Tue and Sat

Airports in Key West

1 airport
The best flight deal from Knoxville to Key West found on momondo in the last 72 hours is $109
The fastest flight from Knoxville to Key West takes 2h 11m
Direct flights go from Knoxville to Key West on Tuesday and Saturday. There are no airlines offering direct flights.
There is 1 airport near Key West: Key West (EYW)
Search flight deals

  • How far is Knoxville McGhee Tyson to Key West by plane?

    Knoxville McGhee Tyson and Key West are 797.5 mi apart from one another. Typically, this will take 2h 11m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Key West Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Key West Airport refresh daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Key West Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Key West Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The required travel and health documents for your Key West Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Key West Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Knoxville to Key West?

  • What is the most popular airline from Knoxville to Key West?

Best airlines flying from Knoxville to Key West

Compare and see reviews for airlines that fly from Knoxville to Key West with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $78Free CancellationRating
7.2
699 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $258Free CancellationRating
7.9
7,961 reviews
Search Delta flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Key West?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Key West from Knoxville.

Can I find flights from Knoxville to Key West with flexible booking policies on momondo?

Flights from Knoxville to Key West with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Key West?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Key West.

I’m not ready to book a flight from Knoxville to Key West right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Key West flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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