Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to Chicago from $53

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 11/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:22 pm - 11:29 pmTYS-MDW
9h 07m1 stop
Multiple Airlines Logo
2:11 pm - 4:36 pmMDW-TYS
1h 25mnonstop
$180Multiple Airlines
Find Deal
Fri, Nov 21 - Mon, Nov 24
Multiple Airlines Logo
12:45 pm - 1:21 pmTYS-MDW
1h 36mnonstop
Multiple Airlines Logo
6:05 am - 10:03 pmMDW-TYS
14h 58m2 stops
$193Multiple Airlines
Find Deal
Fri, Nov 21 - Sun, Nov 23
Delta Logo
7:59 pm - 11:47 pmTYS-MDW
4h 48m1 stop
Delta Logo
1:28 pm - 8:47 pmMDW-TYS
6h 19m1 stop
$209Delta
Find Deal
Mon, Dec 8 - Mon, Jan 19
Allegiant Air Logo
5:49 pm - 6:46 pmTYS-MDW
25h 57m2 stops
Allegiant Air Logo
2:11 pm - 4:36 pmMDW-TYS
1h 25mnonstop
$210Allegiant Air
Find Deal
Thu, Nov 20 - Mon, Nov 24
Multiple Airlines Logo
12:45 pm - 1:21 pmTYS-MDW
1h 36mnonstop
Multiple Airlines Logo
12:25 pm - 10:52 pmMDW-TYS
9h 27m2 stops
$217Multiple Airlines
Find Deal
Fri, Nov 21 - Mon, Nov 24
Allegiant Air Logo
12:45 pm - 1:21 pmTYS-MDW
1h 36mnonstop
Allegiant Air Logo
7:36 pm - 12:16 pmMDW-TYS
39h 40m2 stops
$218Allegiant Air
Find Deal
Fri, Nov 21 - Mon, Nov 24
Delta Logo
7:59 pm - 11:47 pmTYS-MDW
4h 48m1 stop
Delta Logo
6:45 am - 1:52 pmMDW-TYS
6h 07m1 stop
$234Delta
Find Deal
Fri, Dec 12 - Sat, Jan 17
Multiple Airlines Logo
1:05 pm - 10:39 pmTYS-MDW
10h 34m1 stop
Multiple Airlines Logo
6:12 am - 7:04 pmMDW-TYS
35h 52m2 stops
$238Multiple Airlines
Find Deal
Fri, Dec 12 - Fri, Dec 19
Multiple Airlines Logo
5:10 pm - 11:29 pmTYS-MDW
7h 19m1 stop
Multiple Airlines Logo
6:05 am - 10:03 pmMDW-TYS
14h 58m2 stops
$239Multiple Airlines
Find Deal
Fri, Nov 21 - Sun, Nov 23
Multiple Airlines Logo
6:18 pm - 6:54 pmTYS-MDW
1h 36mnonstop
Multiple Airlines Logo
5:30 pm - 3:49 pmMDW-TYS
21h 19m1 stop
$247Multiple Airlines
Find Deal
Wed, Nov 26 - Sun, Nov 30

Southwest flights from Knoxville to Chicago Midway Airport

Our best Southwest deals on Knoxville to Chicago Midway Airport flight tickets
Southwest
Apr 28
TYS2:55 pmKnoxville McGhee Tyson
6h 25m
1 stop
MDW8:20 pmChicago Midway
May 1
MDW12:50 pmChicago Midway
7h 25m
2 stops
TYS9:15 pmKnoxville McGhee Tyson
$268
Find similar
Southwest
Apr 28
TYS2:55 pmKnoxville McGhee Tyson
8h 20m
2 stops
MDW10:15 pmChicago Midway
May 1
MDW12:50 pmChicago Midway
7h 25m
2 stops
TYS9:15 pmKnoxville McGhee Tyson
$273
Find similar
Southwest
Mar 6
TYS6:30 amKnoxville McGhee Tyson
3h 50m
1 stop
MDW9:20 amChicago Midway
Mar 8
MDW6:05 amChicago Midway
6h 50m
1 stop
TYS1:55 pmKnoxville McGhee Tyson
$288
Find similar

Allegiant Air flights from Knoxville to Chicago Midway Airport

Our best Allegiant Air deals on Knoxville to Chicago Midway Airport flight tickets
Allegiant Air
Nov 20
TYS5:49 pmKnoxville McGhee Tyson
25h 57m
2 stops
MDW6:46 pmChicago Midway
Nov 24
MDW2:11 pmChicago Midway
1h 25m
TYS4:36 pmKnoxville McGhee Tyson
$210
Find similar
Allegiant Air
Nov 21
TYS12:45 pmKnoxville McGhee Tyson
1h 36m
MDW1:21 pmChicago Midway
Nov 24
MDW7:36 pmChicago Midway
39h 40m
2 stops
TYS12:16 pmKnoxville McGhee Tyson
$218
Find similar
Allegiant Air
Nov 22
TYS1:45 pmKnoxville McGhee Tyson
20h 37m
1 stop
MDW9:22 amChicago Midway
Nov 24
MDW2:11 pmChicago Midway
1h 25m
TYS4:36 pmKnoxville McGhee Tyson
$225
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Knoxville to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 11/21

3:22 pm-11:29 pm

1 stop9h 07m

Chicago Midway

Mon 11/24

2:11 pm-4:36 pm

Nonstop1h 25m

$180

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 11/21

12:45 pm-1:21 pm

Nonstop1h 36m

Chicago Midway

Sun 11/23

6:05 am-10:03 pm

2 stops14h 58m

$193

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Mon 12/8

7:59 pm-11:47 pm

1 stop4h 48m

Chicago Midway

Mon 1/19

1:28 pm-8:47 pm

1 stop6h 19m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 11/20

5:49 pm-6:46 pm

2 stops25h 57m

Chicago Midway

Mon 11/24

2:11 pm-4:36 pm

Nonstop1h 25m

$210

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 11/21

12:45 pm-1:21 pm

Nonstop1h 36m

Chicago Midway

Mon 11/24

12:25 pm-10:52 pm

2 stops9h 27m

$217

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 11/21

12:45 pm-1:21 pm

Nonstop1h 36m

Chicago Midway

Mon 11/24

7:36 pm-12:16 pm

2 stops39h 40m

$218

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 12/12

7:59 pm-11:47 pm

1 stop4h 48m

Chicago Midway

Sat 1/17

6:45 am-1:52 pm

1 stop6h 07m

$234

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 12/12

1:05 pm-10:39 pm

1 stop10h 34m

Chicago Midway

Fri 12/19

6:12 am-7:04 pm

2 stops35h 52m

$238

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 11/21

5:10 pm-11:29 pm

1 stop7h 19m

Chicago Midway

Sun 11/23

6:05 am-10:03 pm

2 stops14h 58m

$239

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 11/26

6:18 pm-6:54 pm

Nonstop1h 36m

Chicago Midway

Sun 11/30

5:30 pm-3:49 pm

1 stop21h 19m

$247

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Chicago from

How to get the cheapest flight ticket from Knoxville to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago Midway Airport?

The month of September is, on average, the cheapest month to fly to Chicago Midway Airport from Knoxville, with most prices found around $78. If you are unable to visit Chicago Midway Airport during the month of September, then departing from Knoxville during the month July is also very affordable. Most momondo users find prices during this month for around $82.

What is the cheapest day to depart on your flight to Chicago Midway Airport?

According to our data, Sunday is the cheapest day to fly to Chicago Midway Airport from Knoxville. The lowest ticket price found for a Sunday departure recently was $78. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Tuesday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $284.

What is the cheapest time of day to depart on your flight to Chicago Midway Airport?

Flying to Chicago Midway Airport from Knoxville at noon is the least expensive time of day to depart. momondo users have found prices as low as $87 when looking at flights departing at noon. Try not to purchase tickets in the morning because they tend to be around $124. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Knoxville McGhee Tyson to Chicago Midway flight route?

Fly from Knoxville McGhee Tyson to Chicago Midway for the best Knoxville McGhee Tyson - Chicago Midway flight prices

What cabin class options are available on Knoxville McGhee Tyson to Chicago Midway flights?

There is only 1 cabin class available to choose from on Knoxville McGhee Tyson to Chicago Midway flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

When to book flights from Knoxville to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Chicago Midway Airport (TYS to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago Midway Airport

Best Price Found

$77

Fastest flight time

1h 36m

Direct flights

Mon, Thu and Sat
The best one-way flight to Chicago Midway Airport from Knoxville in the past 72 hours is $77. The best round-trip flight deal from Knoxville to Chicago Midway Airport found on momondo in the last 72 hours is $96.
The fastest flight from Knoxville to Chicago Midway Airport takes 1h 36m
Direct flights go from Knoxville to Chicago Midway Airport on Monday, Thursday and Saturday. The only airline offering direct flights is Allegiant Air.
Search flight deals

  • How far is Knoxville McGhee Tyson to Chicago Midway by plane?

    Knoxville McGhee Tyson and Chicago Midway are 451.6 mi apart from one another. A reasonable flight in good conditions will take 1h 36m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The travel and health documents you'll need for your trip to Chicago Midway Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago Midway Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Knoxville to Chicago Midway Airport?

  • What is the most popular airline from Knoxville to Chicago Midway Airport?

Best airlines flying from Knoxville to Chicago Midway Airport

Compare and see reviews for airlines that fly from Knoxville to Chicago Midway Airport with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $60Free CancellationRating
7.2
698 reviews
Search Allegiant Air flights
DeltaPriceFrom $258Free CancellationRating
7.9
8,008 reviews
Search Delta flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Portage
Lansing
Schererville
Valparaiso
Crown Point
Munster
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

It is quick and easy to find Knoxville to Chicago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Chicago that suits you.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Chicago.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Chicago Midway Airport trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 12/13
Sat 12/20
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Chicago