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Cheap flights from Knoxville to Chicago from $103

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 5/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
1:00 pm - 5:37 pm
TYS
-
MDW
5h 37m1 stop
Delta Logo
1:29 pm - 8:55 pm
MDW
-
TYS
6h 26m1 stop
$209Delta
Thu, Feb 26 - Mon, Mar 2
Delta Logo
7:30 am - 12:48 pm
TYS
-
MDW
6h 18m1 stop
Delta Logo
6:00 am - 11:08 am
MDW
-
TYS
4h 08m1 stop
$224Delta
Thu, Jan 8 - Wed, Jan 21
Multiple Airlines Logo
1:39 pm - 7:52 pm
TYS
-
MDW
31h 13m2 stops
Multiple Airlines Logo
10:17 am - 6:41 pm
MDW
-
TYS
7h 24m1 stop
$258Multiple Airlines
Thu, Jan 29 - Sun, Feb 1
Delta Logo
7:30 am - 12:30 pm
TYS
-
MDW
6h 00m1 stop
Delta Logo
1:05 pm - 6:15 pm
MDW
-
TYS
4h 10m1 stop
$274Delta
Sat, May 9 - Mon, May 11
Multiple Airlines Logo
7:26 pm - 10:21 pm
TYS
-
MDW
27h 55m2 stops
Multiple Airlines Logo
10:17 am - 6:41 pm
MDW
-
TYS
7h 24m1 stop
$283Multiple Airlines
Thu, Jan 8 - Sun, Jan 11
Southwest Logo
8:15 am - 4:45 pm
TYS
-
MDW
9h 30m2 stops
Southwest Logo
2:40 pm - 9:05 pm
MDW
-
TYS
5h 25m1 stop
$288Southwest
Tue, Apr 7 - Sun, Apr 12
Delta Logo
5:40 am - 9:53 am
TYS
-
MDW
5h 13m1 stop
Delta Logo
1:26 pm - 8:47 pm
MDW
-
TYS
6h 21m1 stop
$297Delta
Sun, Jan 25 - Thu, Jan 29
Delta Logo
5:30 pm - 9:45 pm
TYS
-
MDW
5h 15m1 stop
Delta Logo
1:05 pm - 6:15 pm
MDW
-
TYS
4h 10m1 stop
$299Delta
Sat, May 9 - Mon, May 11
Southwest Logo
8:15 am - 4:45 pm
TYS
-
MDW
9h 30m2 stops
Southwest Logo
11:35 am - 9:05 pm
MDW
-
TYS
8h 30m2 stops
$303Southwest
Tue, Apr 7 - Sun, Apr 12
Delta Logo
7:30 am - 12:46 pm
TYS
-
MDW
6h 16m1 stop
Delta Logo
1:26 pm - 8:47 pm
MDW
-
TYS
6h 21m1 stop
$309Delta
Fri, Jan 30 - Sun, Feb 1

Delta flights from Knoxville to Chicago Midway Airport

Our best Delta deals on Knoxville to Chicago Midway Airport flight tickets
Delta
Jan 29
TYS7:30 amKnoxville McGhee Tyson
6h 16m
1 stop
MDW12:46 pmChicago Midway
Feb 1
MDW1:26 pmChicago Midway
6h 21m
1 stop
TYS8:47 pmKnoxville McGhee Tyson
$209
Find similar
Delta
Jan 8
TYS7:30 amKnoxville McGhee Tyson
6h 18m
1 stop
MDW12:48 pmChicago Midway
Jan 21
MDW6:00 amChicago Midway
4h 08m
1 stop
TYS11:08 amKnoxville McGhee Tyson
$224
Find similar
Delta
May 9
TYS7:30 amKnoxville McGhee Tyson
6h 00m
1 stop
MDW12:30 pmChicago Midway
May 11
MDW1:05 pmChicago Midway
4h 10m
1 stop
TYS6:15 pmKnoxville McGhee Tyson
$274
Find similar

Southwest flights from Knoxville to Chicago Midway Airport

Our best Southwest deals on Knoxville to Chicago Midway Airport flight tickets
Southwest
Apr 7
TYS8:15 amKnoxville McGhee Tyson
9h 30m
2 stops
MDW4:45 pmChicago Midway
Apr 12
MDW2:40 pmChicago Midway
5h 25m
1 stop
TYS9:05 pmKnoxville McGhee Tyson
$288
Find similar
Southwest
Apr 7
TYS8:15 amKnoxville McGhee Tyson
9h 30m
2 stops
MDW4:45 pmChicago Midway
Apr 12
MDW11:35 amChicago Midway
8h 30m
2 stops
TYS9:05 pmKnoxville McGhee Tyson
$303
Find similar
Southwest
Mar 16
TYS7:25 pmKnoxville McGhee Tyson
5h 40m
1 stop
MDW12:05 amChicago Midway
Mar 20
MDW11:15 amChicago Midway
9h 00m
2 stops
TYS9:15 pmKnoxville McGhee Tyson
$371
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 21, 2025.
Use the filters below to find and compare flights from Knoxville to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 2/26

1:00 pm-5:37 pm

1 stop5h 37m

Chicago Midway

Mon 3/2

1:29 pm-8:55 pm

1 stop6h 26m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 1/8

7:30 am-12:48 pm

1 stop6h 18m

Chicago Midway

Wed 1/21

6:00 am-11:08 am

1 stop4h 08m

$224

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 1/29

1:39 pm-7:52 pm

2 stops31h 13m

Chicago Midway

Sun 2/1

10:17 am-6:41 pm

1 stop7h 24m

$258

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Sat 5/9

7:30 am-12:30 pm

1 stop6h 00m

Chicago Midway

Mon 5/11

1:05 pm-6:15 pm

1 stop4h 10m

$274

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 1/8

7:26 pm-10:21 pm

2 stops27h 55m

Chicago Midway

Sun 1/11

10:17 am-6:41 pm

1 stop7h 24m

$283

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Tue 4/7

8:15 am-4:45 pm

2 stops9h 30m

Chicago Midway

Sun 4/12

2:40 pm-9:05 pm

1 stop5h 25m

$288

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Sun 1/25

5:40 am-9:53 am

1 stop5h 13m

Chicago Midway

Thu 1/29

1:26 pm-8:47 pm

1 stop6h 21m

$297

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Sat 5/9

5:30 pm-9:45 pm

1 stop5h 15m

Chicago Midway

Mon 5/11

1:05 pm-6:15 pm

1 stop4h 10m

$299

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Tue 4/7

8:15 am-4:45 pm

2 stops9h 30m

Chicago Midway

Sun 4/12

11:35 am-9:05 pm

2 stops8h 30m

$303

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 1/30

7:30 am-12:46 pm

1 stop6h 16m

Chicago Midway

Sun 2/1

1:26 pm-8:47 pm

1 stop6h 21m

$309

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Knoxville to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago Midway Airport?

The month of September is, on average, the cheapest month to fly to Chicago Midway Airport from Knoxville, with most prices found around $78. If you are unable to visit Chicago Midway Airport during the month of September, then departing from Knoxville during the month July is also very affordable. Most momondo users find prices during this month for around $82.

What is the cheapest day to depart on your flight to Chicago Midway Airport?

According to our data, Sunday is the cheapest day to fly to Chicago Midway Airport from Knoxville. The lowest ticket price found for a Sunday departure recently was $78. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Wednesday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $264.

What is the cheapest time of day to depart on your flight to Chicago Midway Airport?

Flying to Chicago Midway Airport from Knoxville at noon is the least expensive time of day to depart. momondo users have found prices as low as $86 when looking at flights departing at noon. Try not to purchase tickets in the morning because they tend to be around $124. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Knoxville McGhee Tyson to Chicago Midway flight route?

Fly from Knoxville McGhee Tyson to Chicago Midway for the best Knoxville McGhee Tyson - Chicago Midway flight prices

What cabin class options are available on Knoxville McGhee Tyson to Chicago Midway flights?

There is only 1 cabin class available to choose from on Knoxville McGhee Tyson to Chicago Midway flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Knoxville to Chicago Midway Airport flight prices changed over time?

When to book flights from Knoxville to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Chicago Midway Airport (TYS to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago Midway Airport

Fastest flight time

1h 34m

Direct flights

Mon
The fastest flight from Knoxville to Chicago Midway Airport takes 1h 34m
Direct flights go from Knoxville to Chicago Midway Airport on Monday. The only airline offering direct flights is Allegiant Air.
Search flight deals

  • How far is Knoxville McGhee Tyson to Chicago Midway by plane?

    Knoxville McGhee Tyson and Chicago Midway are 451.6 mi apart from one another. A reasonable flight in good conditions will take 1h 34m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The travel and health documents you'll need for your trip to Chicago Midway Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago Midway Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Knoxville to Chicago Midway Airport?

  • What is the most popular airline from Knoxville to Chicago Midway Airport?

Best airlines flying from Knoxville to Chicago Midway Airport

Compare and see reviews for airlines that fly from Knoxville to Chicago Midway Airport with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $60Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
DeltaPriceFrom $258Free CancellationRating
7.9
8,021 reviews
Search Delta flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Portage
Lansing
Valparaiso
Schererville
Munster
Crown Point
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

It is quick and easy to find Knoxville to Chicago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Chicago that suits you.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Chicago.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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