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Cheap flights from Knoxville to Chicago from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 4/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:35 am - 9:54 am
TYS
-
MDW
5h 19m
1 stop
Delta Logo
10:49 am - 3:15 pm
MDW
-
TYS
3h 26m
1 stop
$209Delta
Thu, Feb 26 - Tue, Mar 3
Delta Logo
2:38 pm - 5:45 pm
TYS
-
MDW
4h 07m
1 stop
Delta Logo
6:00 am - 11:08 am
MDW
-
TYS
4h 08m
1 stop
$244Delta
Tue, Feb 17 - Tue, Feb 24
Delta Logo
11:58 am - 5:29 pm
TYS
-
MDW
6h 31m
1 stop
Delta Logo
6:00 am - 11:08 am
MDW
-
TYS
4h 08m
1 stop
$253Delta
Wed, Feb 11 - Sun, Feb 15
Southwest Logo
12:30 pm - 7:55 pm
TYS
-
MDW
8h 25m
2 stops
Southwest Logo
6:05 am - 1:55 pm
MDW
-
TYS
6h 50m
1 stop
$258Southwest
Wed, Apr 1 - Sun, Apr 5
Delta Logo
7:40 am - 12:29 pm
TYS
-
MDW
5h 49m
1 stop
Delta Logo
6:00 am - 11:17 am
MDW
-
TYS
4h 17m
1 stop
$259Delta
Thu, Apr 9 - Sun, Apr 12
Southwest Logo
12:30 pm - 7:55 pm
TYS
-
MDW
8h 25m
2 stops
Southwest Logo
5:00 am - 12:55 pm
MDW
-
TYS
6h 55m
2 stops
$274Southwest
Wed, Apr 1 - Sun, Apr 5
Delta Logo
5:40 pm - 10:29 pm
TYS
-
MDW
5h 49m
1 stop
Delta Logo
10:35 am - 3:06 pm
MDW
-
TYS
3h 31m
1 stop
$278Delta
Fri, May 1 - Sat, May 9
Southwest Logo
7:25 pm - 12:05 am
TYS
-
MDW
5h 40m
1 stop
Southwest Logo
3:35 pm - 9:10 pm
MDW
-
TYS
4h 35m
1 stop
$283Southwest
Fri, Mar 6 - Tue, Mar 10
Delta Logo
5:40 pm - 10:29 pm
TYS
-
MDW
5h 49m
1 stop
Delta Logo
6:30 am - 11:15 am
MDW
-
TYS
3h 45m
1 stop
$284Delta
Thu, Apr 30 - Sun, May 3
Southwest Logo
7:25 pm - 12:05 am
TYS
-
MDW
5h 40m
1 stop
Southwest Logo
10:30 am - 8:05 pm
MDW
-
TYS
8h 35m
2 stops
$288Southwest
Fri, Mar 6 - Tue, Mar 10

Delta flights from Knoxville to Chicago Midway Airport

Our best Delta deals on Knoxville to Chicago Midway Airport flight tickets
Delta
Feb 26
TYS5:35 amKnoxville McGhee Tyson
5h 19m
1 stop
MDW9:54 amChicago Midway
Mar 3
MDW10:49 amChicago Midway
3h 26m
1 stop
TYS3:15 pmKnoxville McGhee Tyson
$209
Delta
Feb 17
TYS2:38 pmKnoxville McGhee Tyson
4h 07m
1 stop
MDW5:45 pmChicago Midway
Feb 24
MDW6:00 amChicago Midway
4h 08m
1 stop
TYS11:08 amKnoxville McGhee Tyson
$244
Delta
Feb 11
TYS11:58 amKnoxville McGhee Tyson
6h 31m
1 stop
MDW5:29 pmChicago Midway
Feb 15
MDW6:00 amChicago Midway
4h 08m
1 stop
TYS11:08 amKnoxville McGhee Tyson
$253

Southwest flights from Knoxville to Chicago Midway Airport

Our best Southwest deals on Knoxville to Chicago Midway Airport flight tickets
Southwest
Apr 1
TYS12:30 pmKnoxville McGhee Tyson
8h 25m
2 stops
MDW7:55 pmChicago Midway
Apr 5
MDW6:05 amChicago Midway
6h 50m
1 stop
TYS1:55 pmKnoxville McGhee Tyson
$258
Southwest
Apr 1
TYS12:30 pmKnoxville McGhee Tyson
8h 25m
2 stops
MDW7:55 pmChicago Midway
Apr 5
MDW5:00 amChicago Midway
6h 55m
2 stops
TYS12:55 pmKnoxville McGhee Tyson
$274
Southwest
Mar 6
TYS7:25 pmKnoxville McGhee Tyson
5h 40m
1 stop
MDW12:05 amChicago Midway
Mar 10
MDW3:35 pmChicago Midway
4h 35m
1 stop
TYS9:10 pmKnoxville McGhee Tyson
$283

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 22, 2026.
Use the filters below to find and compare flights from Knoxville to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 2/26

5:35 am-9:54 am

1 stop5h 19m

Chicago Midway

Tue 3/3

10:49 am-3:15 pm

1 stop3h 26m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Tue 2/17

2:38 pm-5:45 pm

1 stop4h 07m

Chicago Midway

Tue 2/24

6:00 am-11:08 am

1 stop4h 08m

$244

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 2/11

11:58 am-5:29 pm

1 stop6h 31m

Chicago Midway

Sun 2/15

6:00 am-11:08 am

1 stop4h 08m

$253

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 4/1

12:30 pm-7:55 pm

2 stops8h 25m

Chicago Midway

Sun 4/5

6:05 am-1:55 pm

1 stop6h 50m

$258

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 4/9

7:40 am-12:29 pm

1 stop5h 49m

Chicago Midway

Sun 4/12

6:00 am-11:17 am

1 stop4h 17m

$259

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 4/1

12:30 pm-7:55 pm

2 stops8h 25m

Chicago Midway

Sun 4/5

5:00 am-12:55 pm

2 stops6h 55m

$274

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 5/1

5:40 pm-10:29 pm

1 stop5h 49m

Chicago Midway

Sat 5/9

10:35 am-3:06 pm

1 stop3h 31m

$278

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 3/6

7:25 pm-12:05 am

1 stop5h 40m

Chicago Midway

Tue 3/10

3:35 pm-9:10 pm

1 stop4h 35m

$283

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 4/30

5:40 pm-10:29 pm

1 stop5h 49m

Chicago Midway

Sun 5/3

6:30 am-11:15 am

1 stop3h 45m

$284

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 3/6

7:25 pm-12:05 am

1 stop5h 40m

Chicago Midway

Tue 3/10

10:30 am-8:05 pm

2 stops8h 35m

$288

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Knoxville to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Chicago Midway Airport?

What is the cheapest month to fly to Chicago Midway Airport?

The month of September is, on average, the cheapest month to fly to Chicago Midway Airport from Knoxville, with most prices found around $78. If you are unable to visit Chicago Midway Airport during the month of September, then departing from Knoxville during the month July is also very affordable. Most momondo users find prices during this month for around $82.

What is the cheapest day to depart on your flight to Chicago Midway Airport?

According to our data, Sunday is the cheapest day to fly to Chicago Midway Airport from Knoxville. The lowest ticket price found for a Sunday departure recently was $78. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Wednesday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $264.

What is the cheapest time of day to depart on your flight to Chicago Midway Airport?

Flying to Chicago Midway Airport from Knoxville at noon is the least expensive time of day to depart. momondo users have found prices as low as $86 when looking at flights departing at noon. Try not to purchase tickets in the morning because they tend to be around $124. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Knoxville McGhee Tyson to Chicago Midway flight route?

Fly from Knoxville McGhee Tyson to Chicago Midway for the best Knoxville McGhee Tyson - Chicago Midway flight prices

What cabin class options are available on Knoxville McGhee Tyson to Chicago Midway flights?

There is only 1 cabin class available to choose from on Knoxville McGhee Tyson to Chicago Midway flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Knoxville to Chicago Midway Airport flights?

No. A direct flight is the cheapest option for a flight between Knoxville to Chicago Midway Airport.

How have Knoxville to Chicago Midway Airport flight prices changed over time?

When to book flights from Knoxville to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Chicago Midway Airport (TYS to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago Midway Airport

Fastest flight time

1h 34m

Direct flights

None
The fastest flight from Knoxville to Chicago Midway Airport takes 1h 34m
There are no direct flights from Knoxville to Chicago Midway Airport. There are no popular flight routes from Knoxville to Chicago Midway Airport.
Search flight deals

  • How far is Knoxville McGhee Tyson to Chicago Midway by plane?

    Knoxville McGhee Tyson and Chicago Midway are 451.6 mi apart from one another. A reasonable flight in good conditions will take 1h 34m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The travel and health documents you'll need for your trip to Chicago Midway Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago Midway Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Knoxville to Chicago Midway Airport?

  • What is the most popular airline from Knoxville to Chicago Midway Airport?

Best airlines flying from Knoxville to Chicago Midway Airport

Compare and see reviews for airlines that fly from Knoxville to Chicago Midway Airport with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $60Free CancellationRating
7.2
705 reviews
Search Allegiant Air flights
DeltaPriceFrom $233Free CancellationRating
7.9
8,087 reviews
Search Delta flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Portage
Lansing
Schererville
Valparaiso
Munster
Crown Point
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

It is quick and easy to find Knoxville to Chicago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Chicago that suits you.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Chicago.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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