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Cheap flights from Knoxville to Chicago from $67

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 6/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
Multiple Airlines Logo
12:04 pm - 11:37 pm
MDW
-
TYS
10h 33m
2 stops
$207Multiple Airlines
Thu, May 28 - Mon, Jun 1
Allegiant Air Logo
1:22 pm - 1:56 pm
TYS
-
MDW
1h 34mnonstop
Allegiant Air Logo
2:46 pm - 5:14 pm
MDW
-
TYS
1h 28mnonstop
$222Allegiant Air
Thu, Jun 18 - Sun, Jun 21
Multiple Airlines Logo
1:22 pm - 1:56 pm
TYS
-
MDW
1h 34mnonstop
Multiple Airlines Logo
6:00 am - 11:39 pm
MDW
-
TYS
16h 39m
2 stops
$229Multiple Airlines
Thu, Jun 4 - Mon, Jun 8
Multiple Airlines Logo
9:32 pm - 7:31 pm
TYS
-
MDW
22h 59m
2 stops
Multiple Airlines Logo
9:14 am - 5:30 pm
MDW
-
TYS
7h 16m
1 stop
$235Multiple Airlines
Thu, Apr 23 - Mon, Apr 27
Multiple Airlines Logo
7:00 am - 6:22 pm
TYS
-
MDW
12h 22m
1 stop
Multiple Airlines Logo
9:14 am - 5:30 pm
MDW
-
TYS
7h 16m
1 stop
$236Multiple Airlines
Thu, Apr 23 - Mon, Apr 27
Allegiant Air Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
Allegiant Air Logo
9:14 am - 4:40 pm
MDW
-
TYS
30h 26m
2 stops
$237Allegiant Air
Thu, May 21 - Sun, May 24
Allegiant Air Logo
1:22 pm - 1:56 pm
TYS
-
MDW
1h 34mnonstop
Allegiant Air Logo
2:46 pm - 5:14 pm
MDW
-
TYS
1h 28mnonstop
$248Allegiant Air
Thu, Jun 18 - Sun, Jun 21
Southwest Logo
5:50 pm - 10:15 pm
TYS
-
MDW
5h 25m
1 stop
Southwest Logo
5:30 am - 2:20 pm
MDW
-
TYS
7h 50m
1 stop
$249Southwest
Tue, Apr 28 - Tue, May 5
Allegiant Air Logo
1:22 pm - 1:58 pm
TYS
-
MDW
1h 36mnonstop
Allegiant Air Logo
9:25 pm - 6:03 pm
MDW
-
TYS
19h 38m
1 stop
$250Allegiant Air
Sun, Aug 2 - Fri, Aug 7
Southwest Logo
7:05 am - 1:30 pm
TYS
-
MDW
7h 25m
1 stop
Southwest Logo
3:00 pm - 7:40 pm
MDW
-
TYS
3h 40m
1 stop
$254Southwest
Tue, Apr 21 - Tue, Apr 21

Southwest flights from Knoxville to Chicago Midway Airport

Our best Southwest deals on Knoxville to Chicago Midway Airport flight tickets
Southwest
Apr 28
TYS5:50 pmKnoxville McGhee Tyson
5h 25m
1 stop
MDW10:15 pmChicago Midway
May 5
MDW5:30 amChicago Midway
7h 50m
1 stop
TYS2:20 pmKnoxville McGhee Tyson
$249
Southwest
Apr 21
TYS7:05 amKnoxville McGhee Tyson
7h 25m
1 stop
MDW1:30 pmChicago Midway
Apr 21
MDW3:00 pmChicago Midway
3h 40m
1 stop
TYS7:40 pmKnoxville McGhee Tyson
$254
Southwest
Apr 21
TYS12:50 pmKnoxville McGhee Tyson
5h 40m
1 stop
MDW5:30 pmChicago Midway
Apr 25
MDW7:25 amChicago Midway
6h 55m
1 stop
TYS3:20 pmKnoxville McGhee Tyson
$259

Delta flights from Knoxville to Chicago Midway Airport

Our best Delta deals on Knoxville to Chicago Midway Airport flight tickets
Delta
May 9
TYS5:35 pmKnoxville McGhee Tyson
4h 34m
1 stop
MDW9:09 pmChicago Midway
May 11
MDW9:22 amChicago Midway
3h 58m
1 stop
TYS2:20 pmKnoxville McGhee Tyson
$269
Delta
Apr 14
TYS5:54 pmKnoxville McGhee Tyson
5h 34m
1 stop
MDW10:28 pmChicago Midway
Apr 18
MDW5:21 pmChicago Midway
5h 33m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
$299
Delta
Jul 31
TYS5:40 amKnoxville McGhee Tyson
5h 23m
1 stop
MDW10:03 amChicago Midway
Aug 5
MDW9:20 amChicago Midway
4h 58m
1 stop
TYS3:18 pmKnoxville McGhee Tyson
$319

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 4, 2026.
Use the filters below to find and compare flights from Knoxville to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 5/28

1:22 pm-1:57 pm

Nonstop1h 35m

Chicago Midway

Mon 6/1

12:04 pm-11:37 pm

2 stops10h 33m

$207
Quickest round-trip

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 6/18

1:22 pm-1:56 pm

Nonstop1h 34m

Chicago Midway

Sun 6/21

2:46 pm-5:14 pm

Nonstop1h 28m

$222

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 6/4

1:22 pm-1:56 pm

Nonstop1h 34m

Chicago Midway

Mon 6/8

6:00 am-11:39 pm

2 stops16h 39m

$229

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 4/23

9:32 pm-7:31 pm

2 stops22h 59m

Chicago Midway

Mon 4/27

9:14 am-5:30 pm

1 stop7h 16m

$235

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 4/23

7:00 am-6:22 pm

1 stop12h 22m

Chicago Midway

Mon 4/27

9:14 am-5:30 pm

1 stop7h 16m

$236

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 5/21

1:22 pm-1:57 pm

Nonstop1h 35m

Chicago Midway

Sun 5/24

9:14 am-4:40 pm

2 stops30h 26m

$237

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 6/18

1:22 pm-1:56 pm

Nonstop1h 34m

Chicago Midway

Sun 6/21

2:46 pm-5:14 pm

Nonstop1h 28m

$248

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Tue 4/28

5:50 pm-10:15 pm

1 stop5h 25m

Chicago Midway

Tue 5/5

5:30 am-2:20 pm

1 stop7h 50m

$249

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Sun 8/2

1:22 pm-1:58 pm

Nonstop1h 36m

Chicago Midway

Fri 8/7

9:25 pm-6:03 pm

1 stop19h 38m

$250

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Tue 4/21

7:05 am-1:30 pm

1 stop7h 25m

Chicago Midway

Tue 4/21

3:00 pm-7:40 pm

1 stop3h 40m

$254

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Chicago Midway Airport?

What is the cheapest day to depart on your flight to Chicago Midway Airport?

According to our data, Saturday is the cheapest day to fly to Chicago Midway Airport from Knoxville. The lowest ticket price found for a Saturday departure recently was $61. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Tuesday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $284.

What is the cheapest time of day to depart on your flight to Chicago Midway Airport?

Flying to Chicago Midway Airport from Knoxville at noon is the least expensive time of day to depart. momondo users have found prices as low as $88 when looking at flights departing at noon. Try not to purchase tickets in the morning because they tend to be around $124. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Knoxville McGhee Tyson to Chicago Midway flight route?

Fly from Knoxville McGhee Tyson to Chicago Midway for the best Knoxville McGhee Tyson - Chicago Midway flight prices

What cabin class options are available on Knoxville McGhee Tyson to Chicago Midway flights?

There is only 1 cabin class available to choose from on Knoxville McGhee Tyson to Chicago Midway flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Knoxville to Chicago Midway Airport flights?

No. A direct flight is the cheapest option for a flight between Knoxville to Chicago Midway Airport.

When to book flights from Knoxville to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Chicago Midway Airport (TYS to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago Midway Airport

Best Price Found

$91

Fastest flight time

1h 34m

Direct flights

Mon and Fri
The best flight deal from Knoxville to Chicago Midway Airport found on momondo in the last 72 hours is $91
The fastest flight from Knoxville to Chicago Midway Airport takes 1h 34m
Direct flights go from Knoxville to Chicago Midway Airport on Monday and Friday. The only airline offering direct flights is Allegiant Air.
Search flight deals

Frequently asked questions about flying from Knoxville to Chicago Midway Airport

  • How far is Knoxville McGhee Tyson to Chicago Midway by plane?

    Knoxville McGhee Tyson and Chicago Midway are 451.6 mi apart from one another. A reasonable flight in good conditions will take 1h 34m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The travel and health documents you'll need for your trip to Chicago Midway Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago Midway Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Knoxville to Chicago Midway Airport?

  • What is the most popular airline from Knoxville to Chicago Midway Airport?

Best airlines flying from Knoxville to Chicago Midway Airport

Compare and see reviews for airlines that fly from Knoxville to Chicago Midway Airport with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $60Free CancellationRating
7.3
708 reviews
Search Allegiant Air flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Saint Joseph
Benton Harbor
Portage
Lansing
Valparaiso
Schererville
Munster
Crown Point
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

It is quick and easy to find Knoxville to Chicago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Chicago that suits you.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Chicago.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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