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Cheap flights from Knoxville to Chicago from $49

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 10/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Multiple Airlines Logo
5:44 pm - 6:16 pmTYS-MDW
1h 32mnonstop
Multiple Airlines Logo
9:32 am - 9:55 pmMDW-TYS
11h 23m1 stop
$152Multiple Airlines
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Fri, Oct 31 - Mon, Nov 3
Multiple Airlines Logo
5:44 pm - 6:16 pmTYS-MDW
1h 32mnonstop
Multiple Airlines Logo
9:32 am - 9:55 pmMDW-TYS
11h 23m1 stop
$157Multiple Airlines
Find Deal
Fri, Oct 31 - Mon, Nov 3
Multiple Airlines Logo
6:42 pm - 6:39 pmTYS-MDW
24h 57m2 stops
Multiple Airlines Logo
4:12 pm - 6:37 pmMDW-TYS
1h 25mnonstop
$158Multiple Airlines
Find Deal
Fri, Nov 14 - Mon, Nov 17
Multiple Airlines Logo
2:02 pm - 2:37 pmTYS-MDW
1h 35mnonstop
Multiple Airlines Logo
10:12 am - 1:57 pmMDW-TYS
26h 45m1 stop
$173Multiple Airlines
Find Deal
Fri, Nov 14 - Sun, Nov 16
Allegiant Air Logo
6:45 am - 5:02 pmTYS-MDW
11h 17m2 stops
Allegiant Air Logo
2:45 pm - 5:09 pmMDW-TYS
1h 24mnonstop
$200Allegiant Air
Find Deal
Fri, Oct 31 - Mon, Nov 3
Allegiant Air Logo
7:02 pm - 7:34 pmTYS-MDW
1h 32mnonstop
Allegiant Air Logo
6:40 pm - 11:09 amMDW-TYS
15h 29m1 stop
$201Allegiant Air
Find Deal
Mon, Oct 27 - Thu, Oct 30
Delta Logo
7:59 pm - 11:49 pmTYS-MDW
4h 50m1 stop
Delta Logo
1:14 pm - 8:00 pmMDW-TYS
5h 46m1 stop
$209Delta
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Thu, Dec 11 - Tue, Dec 16
Delta Logo
6:40 am - 1:08 pmTYS-MDW
7h 28m1 stop
Delta Logo
4:23 pm - 11:07 pmMDW-TYS
5h 44m1 stop
$219Delta
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Wed, Oct 29 - Sat, Nov 1
Southwest Logo
7:50 am - 4:25 pmTYS-MDW
9h 35m2 stops
Southwest Logo
2:35 pm - 10:10 pmMDW-TYS
6h 35m2 stops
$298Southwest
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Wed, Mar 11 - Mon, Mar 16
Southwest Logo
12:30 pm - 7:20 pmTYS-MDW
7h 50m1 stop
Southwest Logo
5:25 am - 12:45 pmMDW-TYS
6h 20m1 stop
$299Southwest
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Wed, Mar 11 - Mon, Mar 16

Delta flights from Knoxville to Chicago Midway Airport

Our best Delta deals on Knoxville to Chicago Midway Airport flight tickets
Delta
Dec 11
TYS7:59 pmKnoxville McGhee Tyson
4h 50m
1 stop
MDW11:49 pmChicago Midway
Dec 16
MDW1:14 pmChicago Midway
5h 46m
1 stop
TYS8:00 pmKnoxville McGhee Tyson
$209
Find similar
Delta
Oct 29
TYS6:40 amKnoxville McGhee Tyson
7h 28m
1 stop
MDW1:08 pmChicago Midway
Nov 1
MDW4:23 pmChicago Midway
5h 44m
1 stop
TYS11:07 pmKnoxville McGhee Tyson
$219
Find similar
Delta
Feb 26
TYS6:45 amKnoxville McGhee Tyson
7h 23m
1 stop
MDW1:08 pmChicago Midway
Mar 2
MDW10:35 amChicago Midway
3h 31m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
$234
Find similar

Southwest flights from Knoxville to Chicago Midway Airport

Our best Southwest deals on Knoxville to Chicago Midway Airport flight tickets
Southwest
Mar 11
TYS7:50 amKnoxville McGhee Tyson
9h 35m
2 stops
MDW4:25 pmChicago Midway
Mar 16
MDW2:35 pmChicago Midway
6h 35m
2 stops
TYS10:10 pmKnoxville McGhee Tyson
$298
Find similar
Southwest
Mar 11
TYS12:30 pmKnoxville McGhee Tyson
7h 50m
1 stop
MDW7:20 pmChicago Midway
Mar 16
MDW5:25 amChicago Midway
6h 20m
1 stop
TYS12:45 pmKnoxville McGhee Tyson
$299
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momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Knoxville to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 10/31

5:44 pm-6:16 pm

Nonstop1h 32m

Chicago Midway

Mon 11/3

9:32 am-9:55 pm

1 stop11h 23m

$152

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 10/31

5:44 pm-6:16 pm

Nonstop1h 32m

Chicago Midway

Mon 11/3

9:32 am-9:55 pm

1 stop11h 23m

$157

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 11/14

6:42 pm-6:39 pm

2 stops24h 57m

Chicago Midway

Mon 11/17

4:12 pm-6:37 pm

Nonstop1h 25m

$158

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 11/14

2:02 pm-2:37 pm

Nonstop1h 35m

Chicago Midway

Sun 11/16

10:12 am-1:57 pm

1 stop26h 45m

$173

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 10/31

6:45 am-5:02 pm

2 stops11h 17m

Chicago Midway

Mon 11/3

2:45 pm-5:09 pm

Nonstop1h 24m

$200

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Mon 10/27

7:02 pm-7:34 pm

Nonstop1h 32m

Chicago Midway

Thu 10/30

6:40 pm-11:09 am

1 stop15h 29m

$201

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 12/11

7:59 pm-11:49 pm

1 stop4h 50m

Chicago Midway

Tue 12/16

1:14 pm-8:00 pm

1 stop5h 46m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 10/29

6:40 am-1:08 pm

1 stop7h 28m

Chicago Midway

Sat 11/1

4:23 pm-11:07 pm

1 stop5h 44m

$219

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 3/11

7:50 am-4:25 pm

2 stops9h 35m

Chicago Midway

Mon 3/16

2:35 pm-10:10 pm

2 stops6h 35m

$298

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 3/11

12:30 pm-7:20 pm

1 stop7h 50m

Chicago Midway

Mon 3/16

5:25 am-12:45 pm

1 stop6h 20m

$299

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Knoxville to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago Midway Airport?

The month of September is, on average, the cheapest month to fly to Chicago Midway Airport from Knoxville, with most prices found around $78. If you are unable to visit Chicago Midway Airport during the month of September, then departing from Knoxville during the month July is also very affordable. Most momondo users find prices during this month for around $82.

What is the cheapest day to depart on your flight to Chicago Midway Airport?

According to our data, Sunday is the cheapest day to fly to Chicago Midway Airport from Knoxville. The lowest ticket price found for a Sunday departure recently was $78. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Tuesday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $284.

What is the cheapest time of day to depart on your flight to Chicago Midway Airport?

Flying to Chicago Midway Airport from Knoxville at noon is the least expensive time of day to depart. momondo users have found prices as low as $91 when looking at flights departing at noon. Try not to purchase tickets in the morning because they tend to be around $124. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Knoxville McGhee Tyson to Chicago Midway flight route?

Fly from Knoxville McGhee Tyson to Chicago Midway for the best Knoxville McGhee Tyson - Chicago Midway flight prices

What cabin class options are available on Knoxville McGhee Tyson to Chicago Midway flights?

There is only 1 cabin class available to choose from on Knoxville McGhee Tyson to Chicago Midway flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

When to book flights from Knoxville to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Chicago Midway Airport (TYS to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago Midway Airport

Best Price Found

$93

Fastest flight time

1h 32m

Direct flights

Tue, Thu and Sat
The best one-way flight to Chicago Midway Airport from Knoxville in the past 72 hours is $93. The best round-trip flight deal from Knoxville to Chicago Midway Airport found on momondo in the last 72 hours is $96.
The fastest flight from Knoxville to Chicago Midway Airport takes 1h 32m
Direct flights go from Knoxville to Chicago Midway Airport on Tuesday, Thursday and Saturday. The only airline offering direct flights is Allegiant Air.
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  • How far is Knoxville McGhee Tyson to Chicago Midway by plane?

    Knoxville McGhee Tyson and Chicago Midway are 451.6 mi apart from one another. A reasonable flight in good conditions will take 1h 32m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The travel and health documents you'll need for your trip to Chicago Midway Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago Midway Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Knoxville to Chicago Midway Airport?

  • What is the most popular airline from Knoxville to Chicago Midway Airport?

Best airlines flying from Knoxville to Chicago Midway Airport

Compare and see reviews for airlines that fly from Knoxville to Chicago Midway Airport with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $60Free CancellationRating
7.2
693 reviews
Search Allegiant Air flights
DeltaPriceFrom $233Free CancellationRating
7.9
7,979 reviews
Search Delta flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Portage
Lansing
Schererville
Valparaiso
Crown Point
Munster
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

It is quick and easy to find Knoxville to Chicago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Chicago that suits you.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Chicago.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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