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Cheap flights from Knoxville to Chicago from $107

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 1/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
Allegiant Air Logo
2:47 pm - 5:13 pm
MDW
-
TYS
1h 26mnonstop
$140Allegiant Air
Thu, May 28 - Sun, May 31
Allegiant Air Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
Allegiant Air Logo
2:47 pm - 5:13 pm
MDW
-
TYS
1h 26mnonstop
$187Allegiant Air
Sun, May 24 - Thu, May 28
Allegiant Air Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
Allegiant Air Logo
2:47 pm - 5:13 pm
MDW
-
TYS
1h 26mnonstop
$192Allegiant Air
Sun, May 24 - Sun, May 31
Delta Logo
6:09 pm - 10:07 pm
TYS
-
MDW
4h 58m1 stop
Delta Logo
6:45 am - 1:50 pm
MDW
-
TYS
6h 05m1 stop
$209Delta
Fri, Jan 9 - Sun, Jan 11
Southwest Logo
12:15 pm - 7:00 pm
TYS
-
MDW
7h 45m1 stop
Southwest Logo
1:00 pm - 8:50 pm
MDW
-
TYS
6h 50m1 stop
$244Southwest
Thu, May 14 - Tue, May 19
Southwest Logo
12:15 pm - 7:00 pm
TYS
-
MDW
7h 45m1 stop
Southwest Logo
12:45 pm - 8:50 pm
MDW
-
TYS
7h 05m2 stops
$249Southwest
Thu, May 14 - Tue, May 19
Allegiant Air Logo
9:00 am - 8:24 am
TYS
-
MDW
24h 24m1 stop
Allegiant Air Logo
2:47 pm - 5:13 pm
MDW
-
TYS
1h 26mnonstop
$250Allegiant Air
Wed, May 27 - Sun, May 31
Delta Logo
7:30 am - 12:46 pm
TYS
-
MDW
6h 16m1 stop
Delta Logo
6:00 am - 11:08 am
MDW
-
TYS
4h 08m1 stop
$253Delta
Thu, Feb 12 - Sun, Feb 15
Southwest Logo
5:45 pm - 10:15 pm
TYS
-
MDW
5h 30m1 stop
Southwest Logo
7:25 am - 6:30 pm
MDW
-
TYS
10h 05m2 stops
$258Southwest
Wed, May 27 - Sat, May 30
Southwest Logo
8:15 am - 3:50 pm
TYS
-
MDW
8h 35m2 stops
Southwest Logo
7:25 am - 6:30 pm
MDW
-
TYS
10h 05m2 stops
$263Southwest
Wed, May 27 - Sat, May 30

Allegiant Air flights from Knoxville to Chicago Midway Airport

Our best Allegiant Air deals on Knoxville to Chicago Midway Airport flight tickets
Allegiant Air
May 28
TYS1:22 pmKnoxville McGhee Tyson
1h 35m
MDW1:57 pmChicago Midway
May 31
MDW2:47 pmChicago Midway
1h 26m
TYS5:13 pmKnoxville McGhee Tyson
$140
Find similar
Allegiant Air
May 24
TYS1:22 pmKnoxville McGhee Tyson
1h 35m
MDW1:57 pmChicago Midway
May 28
MDW2:47 pmChicago Midway
1h 26m
TYS5:13 pmKnoxville McGhee Tyson
$187
Find similar
Allegiant Air
May 24
TYS1:22 pmKnoxville McGhee Tyson
1h 35m
MDW1:57 pmChicago Midway
May 31
MDW2:47 pmChicago Midway
1h 26m
TYS5:13 pmKnoxville McGhee Tyson
$192
Find similar

Southwest flights from Knoxville to Chicago Midway Airport

Our best Southwest deals on Knoxville to Chicago Midway Airport flight tickets
Southwest
May 14
TYS12:15 pmKnoxville McGhee Tyson
7h 45m
1 stop
MDW7:00 pmChicago Midway
May 19
MDW1:00 pmChicago Midway
6h 50m
1 stop
TYS8:50 pmKnoxville McGhee Tyson
$244
Find similar
Southwest
May 14
TYS12:15 pmKnoxville McGhee Tyson
7h 45m
1 stop
MDW7:00 pmChicago Midway
May 19
MDW12:45 pmChicago Midway
7h 05m
2 stops
TYS8:50 pmKnoxville McGhee Tyson
$249
Find similar
Southwest
May 27
TYS5:45 pmKnoxville McGhee Tyson
5h 30m
1 stop
MDW10:15 pmChicago Midway
May 30
MDW7:25 amChicago Midway
10h 05m
2 stops
TYS6:30 pmKnoxville McGhee Tyson
$258
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Knoxville to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 5/28

1:22 pm-1:57 pm

Nonstop1h 35m

Chicago Midway

Sun 5/31

2:47 pm-5:13 pm

Nonstop1h 26m

$140

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Sun 5/24

1:22 pm-1:57 pm

Nonstop1h 35m

Chicago Midway

Thu 5/28

2:47 pm-5:13 pm

Nonstop1h 26m

$187

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Sun 5/24

1:22 pm-1:57 pm

Nonstop1h 35m

Chicago Midway

Sun 5/31

2:47 pm-5:13 pm

Nonstop1h 26m

$192

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 1/9

6:09 pm-10:07 pm

1 stop4h 58m

Chicago Midway

Sun 1/11

6:45 am-1:50 pm

1 stop6h 05m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 5/14

12:15 pm-7:00 pm

1 stop7h 45m

Chicago Midway

Tue 5/19

1:00 pm-8:50 pm

1 stop6h 50m

$244

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 5/14

12:15 pm-7:00 pm

1 stop7h 45m

Chicago Midway

Tue 5/19

12:45 pm-8:50 pm

2 stops7h 05m

$249

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 5/27

9:00 am-8:24 am

1 stop24h 24m

Chicago Midway

Sun 5/31

2:47 pm-5:13 pm

Nonstop1h 26m

$250

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 2/12

7:30 am-12:46 pm

1 stop6h 16m

Chicago Midway

Sun 2/15

6:00 am-11:08 am

1 stop4h 08m

$253

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 5/27

5:45 pm-10:15 pm

1 stop5h 30m

Chicago Midway

Sat 5/30

7:25 am-6:30 pm

2 stops10h 05m

$258

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 5/27

8:15 am-3:50 pm

2 stops8h 35m

Chicago Midway

Sat 5/30

7:25 am-6:30 pm

2 stops10h 05m

$263

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Knoxville to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago Midway Airport?

The month of September is, on average, the cheapest month to fly to Chicago Midway Airport from Knoxville, with most prices found around $78. If you are unable to visit Chicago Midway Airport during the month of September, then departing from Knoxville during the month July is also very affordable. Most momondo users find prices during this month for around $82.

What is the cheapest day to depart on your flight to Chicago Midway Airport?

According to our data, Sunday is the cheapest day to fly to Chicago Midway Airport from Knoxville. The lowest ticket price found for a Sunday departure recently was $78. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Wednesday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $264.

What is the cheapest time of day to depart on your flight to Chicago Midway Airport?

Flying to Chicago Midway Airport from Knoxville at noon is the least expensive time of day to depart. momondo users have found prices as low as $85 when looking at flights departing at noon. Try not to purchase tickets in the morning because they tend to be around $124. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Knoxville McGhee Tyson to Chicago Midway flight route?

Fly from Knoxville McGhee Tyson to Chicago Midway for the best Knoxville McGhee Tyson - Chicago Midway flight prices

What cabin class options are available on Knoxville McGhee Tyson to Chicago Midway flights?

There is only 1 cabin class available to choose from on Knoxville McGhee Tyson to Chicago Midway flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Knoxville to Chicago Midway Airport flight prices changed over time?

When to book flights from Knoxville to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Chicago Midway Airport (TYS to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago Midway Airport

Fastest flight time

4h 05m

Direct flights

Mon and Fri
The fastest flight from Knoxville to Chicago Midway Airport takes 4h 05m
Direct flights go from Knoxville to Chicago Midway Airport on Monday and Friday. The only airline offering direct flights is Allegiant Air.
Search flight deals

  • How far is Knoxville McGhee Tyson to Chicago Midway by plane?

    Knoxville McGhee Tyson and Chicago Midway are 451.6 mi apart from one another. A reasonable flight in good conditions will take 4h 05m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The travel and health documents you'll need for your trip to Chicago Midway Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago Midway Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Knoxville to Chicago Midway Airport?

  • What is the most popular airline from Knoxville to Chicago Midway Airport?

Best airlines flying from Knoxville to Chicago Midway Airport

Compare and see reviews for airlines that fly from Knoxville to Chicago Midway Airport with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $60Free CancellationRating
7.2
700 reviews
Search Allegiant Air flights
DeltaPriceFrom $258Free CancellationRating
7.9
8,004 reviews
Search Delta flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Portage
Lansing
Valparaiso
Schererville
Crown Point
Munster
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

It is quick and easy to find Knoxville to Chicago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Chicago that suits you.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Chicago.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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