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Cheap flights from Knoxville to Chicago from $53

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 5/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Knoxville to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:22 pm - 1:56 pm
TYS
-
MDW
1h 34mnonstop
Multiple Airlines Logo
6:00 am - 11:39 pm
MDW
-
TYS
16h 39m
2 stops
$226Multiple Airlines
목, 6월 4 - 월, 6월 8
Multiple Airlines Logo
9:00 am - 11:09 am
TYS
-
MDW
27h 09m
2 stops
Multiple Airlines Logo
9:16 am - 7:55 pm
MDW
-
TYS
9h 39m
1 stop
$230Multiple Airlines
토, 5월 9 - 일, 5월 17
Multiple Airlines Logo
6:20 pm - 6:37 pm
TYS
-
MDW
25h 17m
2 stops
Multiple Airlines Logo
9:14 am - 10:24 pm
MDW
-
TYS
12h 10m
1 stop
$231Multiple Airlines
금, 4월 24 - 월, 4월 27
Allegiant Air Logo
9:00 am - 8:24 am
TYS
-
MDW
24h 24m
1 stop
Allegiant Air Logo
2:47 pm - 5:13 pm
MDW
-
TYS
1h 26mnonstop
$245Allegiant Air
수, 5월 20 - 일, 5월 24
Multiple Airlines Logo
7:00 am - 6:22 pm
TYS
-
MDW
12h 22m
1 stop
Multiple Airlines Logo
6:00 am - 5:30 pm
MDW
-
TYS
34h 30m
2 stops
$248Multiple Airlines
목, 4월 30 - 목, 5월 7
Southwest Logo
5:50 pm - 10:15 pm
TYS
-
MDW
5h 25m
1 stop
Southwest Logo
9:25 am - 5:10 pm
MDW
-
TYS
6h 45m
1 stop
$249Southwest
화, 5월 5 - 화, 5월 12
Multiple Airlines Logo
1:22 pm - 1:56 pm
TYS
-
MDW
1h 34mnonstop
Multiple Airlines Logo
6:00 am - 11:34 pm
MDW
-
TYS
16h 34m
2 stops
$253Multiple Airlines
목, 6월 11 - 월, 6월 15
Southwest Logo
5:50 pm - 10:15 pm
TYS
-
MDW
5h 25m
1 stop
Southwest Logo
12:50 pm - 8:50 pm
MDW
-
TYS
7h 00m
2 stops
$254Southwest
화, 5월 5 - 화, 5월 12
Multiple Airlines Logo
1:22 pm - 1:56 pm
TYS
-
MDW
1h 34mnonstop
Multiple Airlines Logo
6:00 am - 11:34 pm
MDW
-
TYS
16h 34m
2 stops
$256Multiple Airlines
목, 6월 11 - 월, 6월 15
Multiple Airlines Logo
1:23 pm - 1:59 pm
TYS
-
MDW
1h 36mnonstop
Multiple Airlines Logo
12:27 pm - 10:04 am
MDW
-
TYS
20h 37m
2 stops
$257Multiple Airlines
목, 8월 13 - 화, 8월 18

Delta flights from Knoxville to Chicago Midway Airport

Our best Delta deals on Knoxville to Chicago Midway Airport flight tickets
Delta
May 9
TYS5:40 amKnoxville McGhee Tyson
5h 19m
1 stop
MDW9:59 amChicago Midway
May 11
MDW6:23 amChicago Midway
3h 46m
1 stop
TYS11:09 amKnoxville McGhee Tyson
$279
Delta
May 1
TYS7:00 pmKnoxville McGhee Tyson
4h 28m
1 stop
MDW10:28 pmChicago Midway
May 9
MDW9:22 amChicago Midway
3h 58m
1 stop
TYS2:20 pmKnoxville McGhee Tyson
$294
Delta
May 24
TYS7:51 amKnoxville McGhee Tyson
5h 51m
1 stop
MDW12:42 pmChicago Midway
May 26
MDW5:12 pmChicago Midway
5h 44m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
$339

Southwest flights from Knoxville to Chicago Midway Airport

Our best Southwest deals on Knoxville to Chicago Midway Airport flight tickets
Southwest
May 5
TYS5:50 pmKnoxville McGhee Tyson
5h 25m
1 stop
MDW10:15 pmChicago Midway
May 12
MDW9:25 amChicago Midway
6h 45m
1 stop
TYS5:10 pmKnoxville McGhee Tyson
$249
Southwest
May 5
TYS5:50 pmKnoxville McGhee Tyson
5h 25m
1 stop
MDW10:15 pmChicago Midway
May 12
MDW12:50 pmChicago Midway
7h 00m
2 stops
TYS8:50 pmKnoxville McGhee Tyson
$254
Southwest
May 5
TYS2:55 pmKnoxville McGhee Tyson
8h 20m
2 stops
MDW10:15 pmChicago Midway
May 12
MDW9:20 amChicago Midway
9h 20m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
$259

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated 4월 10, 2026.
Use the filters below to find and compare flights from Knoxville to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

목 6/4

1:22 pm-1:56 pm

Nonstop1h 34m

Chicago Midway

월 6/8

6:00 am-11:39 pm

2 stops16h 39m

$226

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

토 5/9

9:00 am-11:09 am

2 stops27h 09m

Chicago Midway

일 5/17

9:16 am-7:55 pm

1 stop9h 39m

$230

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

금 4/24

6:20 pm-6:37 pm

2 stops25h 17m

Chicago Midway

월 4/27

9:14 am-10:24 pm

1 stop12h 10m

$231

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

수 5/20

9:00 am-8:24 am

1 stop24h 24m

Chicago Midway

일 5/24

2:47 pm-5:13 pm

Nonstop1h 26m

$245

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

목 4/30

7:00 am-6:22 pm

1 stop12h 22m

Chicago Midway

목 5/7

6:00 am-5:30 pm

2 stops34h 30m

$248
Quickest round-trip

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

화 5/5

5:50 pm-10:15 pm

1 stop5h 25m

Chicago Midway

화 5/12

9:25 am-5:10 pm

1 stop6h 45m

$249

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

목 6/11

1:22 pm-1:56 pm

Nonstop1h 34m

Chicago Midway

월 6/15

6:00 am-11:34 pm

2 stops16h 34m

$253

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

화 5/5

5:50 pm-10:15 pm

1 stop5h 25m

Chicago Midway

화 5/12

12:50 pm-8:50 pm

2 stops7h 00m

$254

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

목 6/11

1:22 pm-1:56 pm

Nonstop1h 34m

Chicago Midway

월 6/15

6:00 am-11:34 pm

2 stops16h 34m

$256

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

목 8/13

1:23 pm-1:59 pm

Nonstop1h 36m

Chicago Midway

화 8/18

12:27 pm-10:04 am

2 stops20h 37m

$257

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Knoxville to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Chicago Midway Airport?

What is the cheapest day to depart on your flight to Chicago Midway Airport?

According to our data, Saturday is the cheapest day to fly to Chicago Midway Airport from Knoxville. The lowest ticket price found for a Saturday departure recently was $61. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Tuesday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $284.

What is the cheapest time of day to depart on your flight to Chicago Midway Airport?

Flying to Chicago Midway Airport from Knoxville at noon is the least expensive time of day to depart. momondo users have found prices as low as $87 when looking at flights departing at noon. Try not to purchase tickets in the morning because they tend to be around $124. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Knoxville McGhee Tyson to Chicago Midway flight route?

Fly from Knoxville McGhee Tyson to Chicago Midway for the best Knoxville McGhee Tyson - Chicago Midway flight prices

What cabin class options are available on Knoxville McGhee Tyson to Chicago Midway flights?

There is only 1 cabin class available to choose from on Knoxville McGhee Tyson to Chicago Midway flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Knoxville to Chicago Midway Airport flights?

No. A direct flight is the cheapest option for a flight between Knoxville to Chicago Midway Airport.

When to book flights from Knoxville to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Chicago Midway Airport (TYS to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago Midway Airport

Best Price Found

$91

Fastest flight time

1h 32m

Direct flights

Mon and Fri
The best flight deal from Knoxville to Chicago Midway Airport found on momondo in the last 72 hours is $91
The fastest flight from Knoxville to Chicago Midway Airport takes 1h 32m
Direct flights go from Knoxville to Chicago Midway Airport on Monday and Friday. The only airline offering direct flights is Allegiant Air.
Search flight deals

Frequently asked questions about flying from Knoxville to Chicago Midway Airport

  • How far is Knoxville McGhee Tyson to Chicago Midway by plane?

    Knoxville McGhee Tyson and Chicago Midway are 451.6 mi apart from one another. A reasonable flight in good conditions will take 1h 32m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago Midway Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The travel and health documents you'll need for your trip to Chicago Midway Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago Midway Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Knoxville to Chicago Midway Airport?

  • What is the most popular airline from Knoxville to Chicago Midway Airport?

Best airlines flying from Knoxville to Chicago Midway Airport

Compare and see reviews for airlines that fly from Knoxville to Chicago Midway Airport with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $60Free CancellationRating
7.3
705 reviews
Search Allegiant Air flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Saint Joseph
Benton Harbor
Portage
Lansing
Valparaiso
Schererville
Munster
Crown Point
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

It is quick and easy to find Knoxville to Chicago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Chicago that suits you.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Chicago.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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