Cheap flights from Detroit to San Diego from $72

If you are unable to visit San Diego during the month of January, then departing from Detroit during the month April is also very affordable. Most momondo users find prices during this month for around $496.

The cheapest day to depart from Detroit to San Diego is on a Saturday. Travelers who choose to depart for San Diego on a Saturday will often find tickets for as low as $559. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $691. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $604. Flights in the morning are often more expensive with an average ticket price of $621.

Fly from Detroit Metropolitan Wayne County to San Diego for the best Detroit - San Diego flight prices

You are more likely to see cheaper flights to San Diego from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $536 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Detroit for as low as $486 on momondo.

There are 4 cabin classes available to choose from on Detroit to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines, Southwest, and Alaska Airlines are the most popular carriers operating from Detroit to San Diego

Delta, Frontier and Southwest are the top three most popular airlines that fly to San Diego from Detroit according to our data. Delta is the first choice among our users, with 58% of people opting to fly with this airline when traveling to San Diego. Keep in mind that there are 6 different airlines that fly to San Diego on a routine basis, so you have a few additional options to choose from.

Denver (DEN) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Phoenix (PHX) offer the lowest average round-trip price of $211.

Flights connecting via Phoenix (PHX) have the shortest average one-way travel time: 7h 06m.

Dallas (DFW) has the shortest average layover time for this route: 0h 56m.

As of November 2026, there are 8 flights per day flying from Detroit to San Diego. The most common time of day flights depart is 4:00PM, with 75% of flights taking off in the afternoon.

56 flights are operational weekly from Detroit to San Diego as of November 2026. The most popular departure day for this route is Mon, with 14% of flights per week taking off on this day.