Cheap flights from Detroit to San Diego from $76

If you are unable to visit San Diego during the month of April, then departing from Detroit during the month August is also very affordable. Most momondo users find prices during this month for around $258.

The cheapest day to depart from Detroit to San Diego is on a Friday. Travelers who choose to depart for San Diego on a Friday will often find tickets for as low as $487. If your travel schedule is flexible, try to avoid departing on a Wednesday because tickets tend to average around $548. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

The cheapest time of day to fly to San Diego is in the morning when flights can be purchased for as low as $499. Flights in the evening are often more expensive with an average ticket price of $556.

Fly from Detroit Metropolitan Wayne County to San Diego for the best Detroit - San Diego flight prices

You are more likely to see cheaper flights to San Diego from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $427 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Detroit for as low as $290 on momondo.

There are 4 cabin classes available to choose from on Detroit to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Detroit to San Diego.

As of April 2026, prices for Detroit to San Diego flights are approximately 165% more expensive when compared to flights at the same time last year.

United Airlines and Southwest are the most popular carriers operating from Detroit to San Diego

Delta, Spirit Airlines and Frontier are the top three most popular airlines that fly to San Diego from Detroit according to our data. Delta is the first choice among our users, with 56% of people opting to fly with this airline when traveling to San Diego. Keep in mind that there are 7 different airlines that fly to San Diego on a routine basis, so you have a few additional options to choose from.

Las Vegas (LAS) was the most common stop: 35% of momondo users choosing 1-stop flights on this route connected there.

Flights via Denver (DEN) offer the lowest average round-trip price of $162.

Flights connecting via Chicago (ORD) have the shortest average one-way travel time: 6h 40m.

Chicago (ORD) has the shortest average layover time for this route: 0h 47m.

As of April 2026, there are 6 flights per day flying from Detroit to San Diego. The most common time of day flights depart is 3:00PM, with 54% of flights taking off in the afternoon.

47 flights are operational weekly from Detroit to San Diego as of April 2026. The most popular departure day for this route is Mon, with 17% of flights per week taking off on this day.