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Cheap flights from Knoxville to Sao Paulo from $448

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Sao Paulo departing on 5/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:53 pm - 9:00 am
TYS
-
GRU
18h 07m
1 stop
American Airlines Logo
11:15 pm - 7:04 pm
GRU
-
TYS
20h 49m
1 stop
$1,263American Airlines
Mon, Jun 22 - Wed, Jun 24
United Airlines Logo
5:45 am - 9:40 am
TYS
-
GRU
26h 55m
2 stops
United Airlines Logo
10:20 pm - 2:27 pm
GRU
-
TYS
17h 07m
2 stops
$1,267United Airlines
Mon, Jun 22 - Wed, Jun 24
Multiple Airlines Logo
7:27 am - 5:40 am
TYS
-
GRU
21h 13m
1 stop
Multiple Airlines Logo
1:00 am - 3:30 pm
GRU
-
TYS
15h 30m
2 stops
$1,290Multiple Airlines
Sun, May 17 - Mon, Jul 13
LATAM Airlines Logo
3:30 pm - 5:20 am
TYS
-
GRU
36h 50m
2 stops
LATAM Airlines Logo
3:40 am - 11:46 pm
GRU
-
TYS
21h 06m
2 stops
$1,305LATAM Airlines
Sun, May 17 - Mon, Jul 13
United Airlines Logo
6:01 pm - 9:40 am
TYS
-
GRU
14h 39m
1 stop
United Airlines Logo
10:20 pm - 1:19 pm
GRU
-
TYS
15h 59m
1 stop
$1,309United Airlines
Sun, May 17 - Tue, Jul 14
United Airlines Logo
6:01 pm - 9:40 am
TYS
-
GRU
14h 39m
1 stop
United Airlines Logo
10:20 pm - 2:27 pm
GRU
-
TYS
17h 07m
2 stops
$1,313United Airlines
Sun, May 17 - Tue, Jul 14
United Airlines Logo
3:40 pm - 6:30 am
TYS
-
GRU
13h 50m
1 stop
United Airlines Logo
9:30 pm - 2:27 pm
GRU
-
TYS
17h 57m
1 stop
$1,318United Airlines
Fri, May 1 - Sat, May 30
United Airlines Logo
7:00 am - 6:30 am
TYS
-
GRU
22h 30m
2 stops
United Airlines Logo
9:30 pm - 10:42 am
GRU
-
TYS
14h 12m
1 stop
$1,322United Airlines
Fri, May 1 - Sat, May 30
United Airlines Logo
7:19 pm - 9:30 am
TYS
-
GRU
13h 11m
1 stop
United Airlines Logo
10:20 pm - 5:12 pm
GRU
-
TYS
19h 52m
1 stop
$1,353United Airlines
Thu, May 28 - Mon, Jun 1
United Airlines Logo
10:45 am - 7:10 am
TYS
-
GRU
19h 25m
2 stops
United Airlines Logo
9:30 pm - 10:42 am
GRU
-
TYS
14h 12m
1 stop
$1,357United Airlines
Thu, May 28 - Mon, Jun 1

United Airlines flights from Knoxville to Sao Paulo

Our best United Airlines deals on Knoxville to Sao Paulo flight tickets
United Airlines
Jun 22
TYS5:45 amKnoxville McGhee Tyson
26h 55m
2 stops
GRU9:40 amSao Paulo Guarulhos Intl
Jun 24
GRU10:20 pmSao Paulo Guarulhos Intl
17h 07m
2 stops
TYS2:27 pmKnoxville McGhee Tyson
$1,267
United Airlines
May 17
TYS6:01 pmKnoxville McGhee Tyson
14h 39m
1 stop
GRU9:40 amSao Paulo Guarulhos Intl
Jul 14
GRU10:20 pmSao Paulo Guarulhos Intl
15h 59m
1 stop
TYS1:19 pmKnoxville McGhee Tyson
$1,309
United Airlines
May 17
TYS6:01 pmKnoxville McGhee Tyson
14h 39m
1 stop
GRU9:40 amSao Paulo Guarulhos Intl
Jul 14
GRU10:20 pmSao Paulo Guarulhos Intl
17h 07m
2 stops
TYS2:27 pmKnoxville McGhee Tyson
$1,313

LATAM Airlines flights from Knoxville to Sao Paulo

Our best LATAM Airlines deals on Knoxville to Sao Paulo flight tickets
LATAM Airlines
May 17
TYS3:30 pmKnoxville McGhee Tyson
36h 50m
2 stops
GRU5:20 amSao Paulo Guarulhos Intl
Jul 13
GRU3:40 amSao Paulo Guarulhos Intl
21h 06m
2 stops
TYS11:46 pmKnoxville McGhee Tyson
$1,305
LATAM Airlines
Mar 25
TYS5:10 pmKnoxville McGhee Tyson
15h 25m
1 stop
GRU9:35 amSao Paulo Guarulhos Intl
Mar 27
GRU10:40 amSao Paulo Guarulhos Intl
14h 17m
1 stop
TYS11:57 pmKnoxville McGhee Tyson
$2,000
LATAM Airlines
Mar 25
TYS5:10 pmKnoxville McGhee Tyson
22h 10m
2 stops
GRU4:20 pmSao Paulo Guarulhos Intl
Mar 27
GRU10:50 pmSao Paulo Guarulhos Intl
26h 07m
2 stops
TYS11:57 pmKnoxville McGhee Tyson
$2,144

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Sao Paulo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 21, 2026.
Use the filters below to find and compare flights from Knoxville to Sao Paulo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Mon 6/22

1:53 pm-9:00 am

1 stop18h 07m

Sao Paulo Guarulhos Intl

Wed 6/24

11:15 pm-7:04 pm

1 stop20h 49m

$1,263

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Mon 6/22

5:45 am-9:40 am

2 stops26h 55m

Sao Paulo Guarulhos Intl

Wed 6/24

10:20 pm-2:27 pm

2 stops17h 07m

$1,267

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 5/17

7:27 am-5:40 am

1 stop21h 13m

Sao Paulo Guarulhos Intl

Mon 7/13

1:00 am-3:30 pm

2 stops15h 30m

$1,290

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 5/17

3:30 pm-5:20 am

2 stops36h 50m

Sao Paulo Guarulhos Intl

Mon 7/13

3:40 am-11:46 pm

2 stops21h 06m

$1,305
Quickest round-trip

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 5/17

6:01 pm-9:40 am

1 stop14h 39m

Sao Paulo Guarulhos Intl

Tue 7/14

10:20 pm-1:19 pm

1 stop15h 59m

$1,309

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 5/17

6:01 pm-9:40 am

1 stop14h 39m

Sao Paulo Guarulhos Intl

Tue 7/14

10:20 pm-2:27 pm

2 stops17h 07m

$1,313

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Fri 5/1

3:40 pm-6:30 am

1 stop13h 50m

Sao Paulo Guarulhos Intl

Sat 5/30

9:30 pm-2:27 pm

1 stop17h 57m

$1,318

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Fri 5/1

7:00 am-6:30 am

2 stops22h 30m

Sao Paulo Guarulhos Intl

Sat 5/30

9:30 pm-10:42 am

1 stop14h 12m

$1,322

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Thu 5/28

7:19 pm-9:30 am

1 stop13h 11m

Sao Paulo Guarulhos Intl

Mon 6/1

10:20 pm-5:12 pm

1 stop19h 52m

$1,353

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Thu 5/28

10:45 am-7:10 am

2 stops19h 25m

Sao Paulo Guarulhos Intl

Mon 6/1

9:30 pm-10:42 am

1 stop14h 12m

$1,357

Flights are sorted by cheapest round-trip flights first.

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How to get the cheapest flight ticket from Knoxville to Sao Paulo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Knoxville to Sao Paulo flights?

You could potentially save up to 39% on your flight if you consider stops on a Knoxville to Sao Paulo flight.

When to book flights from Knoxville to Sao Paulo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Sao Paulo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Sao Paulo (TYS to SAO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Sao Paulo

Fastest flight time

14h 43m

Direct flights

None
The fastest flight from Knoxville to Sao Paulo takes 14h 43m
There are no direct flights from Knoxville to Sao Paulo. There are no popular flight routes from Knoxville to Sao Paulo.
Search flight deals

  • How far is Knoxville McGhee Tyson to Sao Paulo by plane?

    There are 4775.1 mi between Knoxville McGhee Tyson and Sao Paulo. Flights usually cover this in 14h 43m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Sao Paulo?

    Prices for flights from Knoxville McGhee Tyson Airport to Sao Paulo are updated daily.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Sao Paulo?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Sao Paulo.

  • What documentation or ID do you need to fly to Sao Paulo?

    The required travel and health documents for your Sao Paulo trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Sao Paulo. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Sao Paulo?

Book flights to Sao Paulo if you plan to visit one of these locations
Santos
Guarujá

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Sao Paulo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Sao Paulo from Knoxville.

Can I find flights from Knoxville to Sao Paulo with flexible booking policies on momondo?

All flight searches from Knoxville to Sao Paulo on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Sao Paulo?

Once all potential Knoxville to Sao Paulo flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Sao Paulo right now. Can momondo alert me if prices change?

Price alerts on flights to Sao Paulo from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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Find better results for your trip to Brazil

Fly into one of these airports located in Sao Paulo

Airports listed have a maximum distance of 48.9 mi from Sao Paulo
Sao Paulo Congonhas Airport
Sao Paulo Guarulhos Intl Airport
Sao Paulo Viracopos Airport