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Cheap flights from Knoxville to San Antonio from $109

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Antonio departing on 12/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:00 pm - 9:58 pmTYS-SAT
7h 58m1 stop
American Airlines Logo
4:40 pm - 10:47 pmSAT-TYS
5h 07m1 stop
$159American Airlines
Find Deal
Sat, Jan 17 - Sat, Jan 24
American Airlines Logo
5:14 pm - 9:58 pmTYS-SAT
5h 44m1 stop
American Airlines Logo
6:36 am - 4:17 pmSAT-TYS
8h 41m1 stop
$163American Airlines
Find Deal
Mon, Jan 12 - Sat, Jan 17
United Airlines Logo
11:10 am - 7:41 pmTYS-SAT
9h 31m2 stops
United Airlines Logo
2:05 pm - 9:02 pmSAT-TYS
5h 57m1 stop
$204United Airlines
Find Deal
Tue, Jan 27 - Fri, Jan 30
Delta Logo
12:00 pm - 3:31 pmTYS-SAT
4h 31m1 stop
Delta Logo
5:20 am - 11:47 amSAT-TYS
5h 27m1 stop
$217Delta
Find Deal
Tue, Jan 13 - Tue, Jan 20
United Airlines Logo
6:45 am - 3:31 pmTYS-SAT
9h 46m2 stops
United Airlines Logo
2:05 pm - 9:02 pmSAT-TYS
5h 57m1 stop
$226United Airlines
Find Deal
Sun, Jan 25 - Wed, Jan 28
Multiple Airlines Logo
1:00 pm - 10:27 pmTYS-SAT
10h 27m1 stop
Multiple Airlines Logo
6:00 am - 6:36 pmSAT-TYS
11h 36m1 stop
$244Multiple Airlines
Find Deal
Tue, Jan 13 - Thu, Jan 22
Delta Logo
2:30 pm - 8:27 pmTYS-SAT
6h 57m1 stop
Delta Logo
5:30 am - 10:30 amSAT-TYS
4h 00m1 stop
$268Delta
Find Deal
Tue, Jan 13 - Sat, Jan 17
Multiple Airlines Logo
11:23 am - 6:32 pmTYS-SAT
8h 09m1 stop
Multiple Airlines Logo
3:12 pm - 6:22 pmSAT-TYS
26h 10m1 stop
$272Multiple Airlines
Find Deal
Tue, Nov 4 - Sat, Nov 8
Southwest Logo
4:55 pm - 9:00 pmTYS-SAT
5h 05m1 stop
Southwest Logo
6:00 am - 11:50 amSAT-TYS
4h 50m1 stop
$301Southwest
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Sat, Mar 7 - Wed, Mar 11
Southwest Logo
4:55 pm - 9:00 pmTYS-SAT
5h 05m1 stop
Southwest Logo
10:55 am - 8:05 pmSAT-TYS
8h 10m2 stops
$306Southwest
Find Deal
Sat, Mar 7 - Wed, Mar 11

American Airlines flights from Knoxville to San Antonio

Our best American Airlines deals on Knoxville to San Antonio flight tickets
American Airlines
Jan 17
TYS3:00 pmKnoxville McGhee Tyson
7h 58m
1 stop
SAT9:58 pmSan Antonio
Jan 24
SAT4:40 pmSan Antonio
5h 07m
1 stop
TYS10:47 pmKnoxville McGhee Tyson
$159
Find similar
American Airlines
Jan 12
TYS5:14 pmKnoxville McGhee Tyson
5h 44m
1 stop
SAT9:58 pmSan Antonio
Jan 17
SAT6:36 amSan Antonio
8h 41m
1 stop
TYS4:17 pmKnoxville McGhee Tyson
$163
Find similar
American Airlines
Jan 6
TYS4:44 pmKnoxville McGhee Tyson
5h 05m
1 stop
SAT8:49 pmSan Antonio
Jan 9
SAT6:36 amSan Antonio
8h 10m
1 stop
TYS3:46 pmKnoxville McGhee Tyson
$179
Find similar

United Airlines flights from Knoxville to San Antonio

Our best United Airlines deals on Knoxville to San Antonio flight tickets
United Airlines
Jan 27
TYS11:10 amKnoxville McGhee Tyson
9h 31m
2 stops
SAT7:41 pmSan Antonio
Jan 30
SAT2:05 pmSan Antonio
5h 57m
1 stop
TYS9:02 pmKnoxville McGhee Tyson
$204
Find similar
United Airlines
Jan 25
TYS6:45 amKnoxville McGhee Tyson
9h 46m
2 stops
SAT3:31 pmSan Antonio
Jan 28
SAT2:05 pmSan Antonio
5h 57m
1 stop
TYS9:02 pmKnoxville McGhee Tyson
$226
Find similar
United Airlines
Jan 6
TYS11:10 amKnoxville McGhee Tyson
9h 31m
2 stops
SAT7:41 pmSan Antonio
Jan 9
SAT5:59 pmSan Antonio
4h 45m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
$236
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 1/17

3:00 pm-9:58 pm

1 stop7h 58m

San Antonio

Sat 1/24

4:40 pm-10:47 pm

1 stop5h 07m

$159

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Mon 1/12

5:14 pm-9:58 pm

1 stop5h 44m

San Antonio

Sat 1/17

6:36 am-4:17 pm

1 stop8h 41m

$163

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 1/27

11:10 am-7:41 pm

2 stops9h 31m

San Antonio

Fri 1/30

2:05 pm-9:02 pm

1 stop5h 57m

$204

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 1/13

12:00 pm-3:31 pm

1 stop4h 31m

San Antonio

Tue 1/20

5:20 am-11:47 am

1 stop5h 27m

$217

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sun 1/25

6:45 am-3:31 pm

2 stops9h 46m

San Antonio

Wed 1/28

2:05 pm-9:02 pm

1 stop5h 57m

$226

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 1/13

1:00 pm-10:27 pm

1 stop10h 27m

San Antonio

Thu 1/22

6:00 am-6:36 pm

1 stop11h 36m

$244

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 1/13

2:30 pm-8:27 pm

1 stop6h 57m

San Antonio

Sat 1/17

5:30 am-10:30 am

1 stop4h 00m

$268

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 11/4

11:23 am-6:32 pm

1 stop8h 09m

San Antonio

Sat 11/8

3:12 pm-6:22 pm

1 stop26h 10m

$272

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 3/7

4:55 pm-9:00 pm

1 stop5h 05m

San Antonio

Wed 3/11

6:00 am-11:50 am

1 stop4h 50m

$301

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 3/7

4:55 pm-9:00 pm

1 stop5h 05m

San Antonio

Wed 3/11

10:55 am-8:05 pm

2 stops8h 10m

$306

Flights are sorted by cheapest round-trip flights first.

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See travel insights to San Antonio from

How to get the cheapest flight ticket from Knoxville to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of July, then book flights to San Antonio from Knoxville during January instead. Flights to San Antonio in January, while not as cheap as those in July, still average around $268.

What is the cheapest day to depart on your flight to San Antonio?

The cheapest day to depart on your flight to San Antonio is on a Friday when prices can be found for as low as $284. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to San Antonio on Sunday is $480.

What is the cheapest time of day to depart on your flight to San Antonio?

According to our data, the cheapest time of day to fly to San Antonio is in the evening. momondo users have found flights departing from Knoxville to San Antonio in the evening for as low as $279. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to San Antonio are more costly in the morning, with an average ticket price of $343. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to San Antonio?

You are more likely to see cheaper flights to San Antonio from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $358 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Knoxville for as low as $257 on momondo.

How have Knoxville to San Antonio flight prices changed over time?

When to book flights from Knoxville to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Antonio (TYS to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Antonio

Direct flights

None
There are no direct flights from Knoxville to San Antonio. There are no popular flight routes from Knoxville to San Antonio.
Search flight deals

  • How far is Knoxville McGhee Tyson to San Antonio by plane?

    San Antonio is 958.1 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 4h 31m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Antonio Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Antonio Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The required travel and health documents for your San Antonio Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Antonio Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Antonio?

Best airlines flying from Knoxville to San Antonio

Compare and see reviews for airlines that fly from Knoxville to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $205Free CancellationRating
7.9
7,981 reviews
Search Delta flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
8,988 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,029 reviews
Search American Airlines flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Schertz
Pleasanton

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Antonio?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Antonio from Knoxville.

Can I find flights from Knoxville to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to San Antonio?

momondo helps you find the best flight between Knoxville and San Antonio by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to San Antonio right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Antonio from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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