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Cheap flights from Knoxville to San Antonio from $129

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Antonio departing on 5/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:32 pm - 6:59 pm
TYS
-
SAT
23h 27m
1 stop
Frontier Logo
7:54 pm - 7:33 pm
SAT
-
TYS
22h 39m
1 stop
$233Frontier
Mon, Jun 1 - Sun, Jun 7
Frontier Logo
8:32 pm - 6:56 pm
TYS
-
SAT
23h 24m
1 stop
Frontier Logo
7:51 pm - 7:37 pm
SAT
-
TYS
22h 46m
1 stop
$260Frontier
Mon, Jun 22 - Thu, Jun 25
American Airlines Logo
6:07 pm - 10:17 pm
TYS
-
SAT
5h 10m
1 stop
American Airlines Logo
5:52 pm - 11:47 pm
SAT
-
TYS
4h 55m
1 stop
$267American Airlines
Wed, May 27 - Tue, Jun 2
Delta Logo
7:33 pm - 12:44 am
TYS
-
SAT
6h 11m
1 stop
Delta Logo
10:52 am - 5:11 pm
SAT
-
TYS
5h 19m
1 stop
$268Delta
Tue, Jun 2 - Wed, Jun 3
American Airlines Logo
8:11 pm - 11:59 pm
TYS
-
SAT
4h 48m
1 stop
American Airlines Logo
5:52 pm - 11:47 pm
SAT
-
TYS
4h 55m
1 stop
$274American Airlines
Thu, May 28 - Mon, Jun 1
American Airlines Logo
6:07 pm - 10:17 pm
TYS
-
SAT
5h 10m
1 stop
American Airlines Logo
6:15 am - 3:49 pm
SAT
-
TYS
8h 34m
1 stop
$279American Airlines
Wed, Jun 3 - Sat, Jun 6
Delta Logo
7:33 pm - 12:44 am
TYS
-
SAT
6h 11m
1 stop
Delta Logo
5:00 pm - 12:01 am
SAT
-
TYS
6h 01m
1 stop
$283Delta
Wed, May 27 - Wed, Jun 3
American Airlines Logo
5:00 am - 9:10 am
TYS
-
SAT
5h 10m
1 stop
American Airlines Logo
5:35 pm - 11:55 pm
SAT
-
TYS
5h 20m
1 stop
$284American Airlines
Wed, Jun 3 - Sat, Jun 6
American Airlines Logo
5:00 am - 9:10 am
TYS
-
SAT
5h 10m
1 stop
American Airlines Logo
5:35 pm - 11:55 pm
SAT
-
TYS
5h 20m
1 stop
$289American Airlines
Wed, Jun 3 - Sat, Jun 6
Southwest Logo
7:45 pm - 1:00 am
TYS
-
SAT
6h 15m
1 stop
Southwest Logo
12:20 pm - 8:20 pm
SAT
-
TYS
7h 00m
1 stop
$293Southwest
Fri, Jun 26 - Tue, Jun 30

Delta flights from Knoxville to San Antonio

Our best Delta deals on Knoxville to San Antonio flight tickets
Delta
Jun 2
TYS7:33 pmKnoxville McGhee Tyson
6h 11m
1 stop
SAT12:44 amSan Antonio
Jun 3
SAT10:52 amSan Antonio
5h 19m
1 stop
TYS5:11 pmKnoxville McGhee Tyson
$268
Delta
May 27
TYS7:33 pmKnoxville McGhee Tyson
6h 11m
1 stop
SAT12:44 amSan Antonio
Jun 3
SAT5:00 pmSan Antonio
6h 01m
1 stop
TYS12:01 amKnoxville McGhee Tyson
$283
Delta
Jul 15
TYS5:40 amKnoxville McGhee Tyson
6h 29m
1 stop
SAT11:09 amSan Antonio
Jul 17
SAT5:20 amSan Antonio
4h 45m
1 stop
TYS11:05 amKnoxville McGhee Tyson
$314

Southwest flights from Knoxville to San Antonio

Our best Southwest deals on Knoxville to San Antonio flight tickets
Southwest
Jun 26
TYS7:45 pmKnoxville McGhee Tyson
6h 15m
1 stop
SAT1:00 amSan Antonio
Jun 30
SAT12:20 pmSan Antonio
7h 00m
1 stop
TYS8:20 pmKnoxville McGhee Tyson
$293
Southwest
May 27
TYS12:50 pmKnoxville McGhee Tyson
9h 15m
1 stop
SAT9:05 pmSan Antonio
Jun 5
SAT11:45 amSan Antonio
8h 25m
2 stops
TYS9:10 pmKnoxville McGhee Tyson
$304
Southwest
Jun 26
TYS7:45 pmKnoxville McGhee Tyson
6h 15m
1 stop
SAT1:00 amSan Antonio
Jun 30
SAT6:10 amSan Antonio
6h 55m
2 stops
TYS2:05 pmKnoxville McGhee Tyson
$308

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 8, 2026.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Mon 6/1

8:32 pm-6:59 pm

1 stop23h 27m

San Antonio

Sun 6/7

7:54 pm-7:33 pm

1 stop22h 39m

$233

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Mon 6/22

8:32 pm-6:56 pm

1 stop23h 24m

San Antonio

Thu 6/25

7:51 pm-7:37 pm

1 stop22h 46m

$260

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 5/27

6:07 pm-10:17 pm

1 stop5h 10m

San Antonio

Tue 6/2

5:52 pm-11:47 pm

1 stop4h 55m

$267

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 6/2

7:33 pm-12:44 am

1 stop6h 11m

San Antonio

Wed 6/3

10:52 am-5:11 pm

1 stop5h 19m

$268
Quickest round-trip

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 5/28

8:11 pm-11:59 pm

1 stop4h 48m

San Antonio

Mon 6/1

5:52 pm-11:47 pm

1 stop4h 55m

$274

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 6/3

6:07 pm-10:17 pm

1 stop5h 10m

San Antonio

Sat 6/6

6:15 am-3:49 pm

1 stop8h 34m

$279

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 5/27

7:33 pm-12:44 am

1 stop6h 11m

San Antonio

Wed 6/3

5:00 pm-12:01 am

1 stop6h 01m

$283

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 6/3

5:00 am-9:10 am

1 stop5h 10m

San Antonio

Sat 6/6

5:35 pm-11:55 pm

1 stop5h 20m

$284

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 6/3

5:00 am-9:10 am

1 stop5h 10m

San Antonio

Sat 6/6

5:35 pm-11:55 pm

1 stop5h 20m

$289

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Fri 6/26

7:45 pm-1:00 am

1 stop6h 15m

San Antonio

Tue 6/30

12:20 pm-8:20 pm

1 stop7h 00m

$293

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Knoxville to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and San Antonio?

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of July, then book flights to San Antonio from Knoxville during September instead. Flights to San Antonio in September, while not as cheap as those in July, still average around $273.

How far in advance should I book a flight from Knoxville to San Antonio?

You are more likely to see cheaper flights to San Antonio from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $345 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Knoxville for as low as $243 on momondo.

How have Knoxville to San Antonio flight prices changed over time?

When to book flights from Knoxville to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Antonio (TYS to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Antonio

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Knoxville to San Antonio takes 4h 05m
There are no direct flights from Knoxville to San Antonio. There are no popular flight routes from Knoxville to San Antonio.
Search flight deals

Frequently asked questions about flying from Knoxville to San Antonio

  • How far is Knoxville McGhee Tyson to San Antonio by plane?

    San Antonio is 958.1 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 4h 05m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Antonio Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Antonio Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The required travel and health documents for your San Antonio Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Antonio Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Antonio?

Best airlines flying from Knoxville to San Antonio

Compare and see reviews for airlines that fly from Knoxville to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $207Free CancellationRating
7.9
8,456 reviews
Search Delta flights
SouthwestPriceFrom $216Free CancellationRating
7.9
4,302 reviews
Search Southwest flights
American AirlinesPriceFrom $232Free CancellationRating
7.1
11,666 reviews
Search American Airlines flights
United AirlinesPriceFrom $236Free CancellationRating
7.4
9,694 reviews
Search United Airlines flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Pleasanton
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Antonio?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Antonio from Knoxville.

Can I find flights from Knoxville to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to San Antonio?

momondo helps you find the best flight between Knoxville and San Antonio by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to San Antonio right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Antonio from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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