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Cheap flights from Knoxville to San Antonio from $135

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Antonio departing on 5/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
5:40 pm - 11:10 pm
TYS
-
SAT
6h 30m
1 stop
Southwest Logo
10:00 am - 7:35 pm
SAT
-
TYS
8h 35m
1 stop
$257Southwest
Sat, May 2 - Sat, May 9
Southwest Logo
6:40 am - 10:20 am
TYS
-
SAT
4h 40m
1 stop
Southwest Logo
9:15 am - 6:30 pm
SAT
-
TYS
8h 15m
2 stops
$262Southwest
Sat, May 2 - Sat, May 9
Southwest Logo
6:40 am - 2:50 pm
TYS
-
SAT
9h 10m
2 stops
Southwest Logo
9:15 am - 6:30 pm
SAT
-
TYS
8h 15m
2 stops
$267Southwest
Sat, May 2 - Sat, May 9
American Airlines Logo
4:09 pm - 10:52 pm
TYS
-
SAT
7h 43m
1 stop
American Airlines Logo
6:20 am - 3:45 pm
SAT
-
TYS
8h 25m
1 stop
$274American Airlines
Thu, Apr 30 - Wed, May 6
Delta Logo
5:40 am - 9:52 am
TYS
-
SAT
5h 12m
1 stop
Delta Logo
5:00 pm - 12:01 am
SAT
-
TYS
6h 01m
1 stop
$279Delta
Wed, Jun 3 - Sat, Jun 6
Multiple Airlines Logo
9:32 pm - 11:51 pm
TYS
-
SAT
27h 19m
1 stop
Multiple Airlines Logo
6:00 am - 8:42 pm
SAT
-
TYS
13h 42m
1 stop
$283Multiple Airlines
Thu, Apr 16 - Thu, Apr 23
Multiple Airlines Logo
9:00 am - 9:27 am
TYS
-
SAT
25h 27m
1 stop
Multiple Airlines Logo
10:22 am - 10:05 pm
SAT
-
TYS
10h 43m
1 stop
$285Multiple Airlines
Mon, Apr 6 - Thu, Apr 9
American Airlines Logo
6:54 pm - 11:56 pm
TYS
-
SAT
6h 02m
1 stop
American Airlines Logo
5:42 pm - 11:55 pm
SAT
-
TYS
5h 13m
1 stop
$291American Airlines
Thu, Apr 23 - Mon, Apr 27
Multiple Airlines Logo
1:15 pm - 12:27 pm
TYS
-
SAT
24h 12m
1 stop
Multiple Airlines Logo
6:00 am - 2:45 pm
SAT
-
TYS
7h 45m
1 stop
$294Multiple Airlines
Mon, Apr 13 - Thu, Apr 16
Delta Logo
5:20 pm - 10:27 pm
TYS
-
SAT
6h 07m
1 stop
Delta Logo
5:00 pm - 12:01 am
SAT
-
TYS
6h 01m
1 stop
$297Delta
Wed, Jun 3 - Sat, Jun 6

American Airlines flights from Knoxville to San Antonio

Our best American Airlines deals on Knoxville to San Antonio flight tickets
American Airlines
Apr 30
TYS4:09 pmKnoxville McGhee Tyson
7h 43m
1 stop
SAT10:52 pmSan Antonio
May 6
SAT6:20 amSan Antonio
8h 25m
1 stop
TYS3:45 pmKnoxville McGhee Tyson
$274
American Airlines
Apr 23
TYS6:54 pmKnoxville McGhee Tyson
6h 02m
1 stop
SAT11:56 pmSan Antonio
Apr 27
SAT5:42 pmSan Antonio
5h 13m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
$291
American Airlines
May 20
TYS6:54 pmKnoxville McGhee Tyson
4h 58m
1 stop
SAT10:52 pmSan Antonio
May 23
SAT5:52 pmSan Antonio
4h 55m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$313

United Airlines flights from Knoxville to San Antonio

Our best United Airlines deals on Knoxville to San Antonio flight tickets
United Airlines
Jul 1
TYS8:20 amKnoxville McGhee Tyson
8h 43m
1 stop
SAT4:03 pmSan Antonio
Jul 6
SAT5:23 pmSan Antonio
6h 12m
1 stop
TYS12:35 amKnoxville McGhee Tyson
$303
United Airlines
May 7
TYS6:01 pmKnoxville McGhee Tyson
5h 53m
1 stop
SAT10:54 pmSan Antonio
May 10
SAT2:00 pmSan Antonio
5h 45m
1 stop
TYS8:45 pmKnoxville McGhee Tyson
$310
United Airlines
Jul 1
TYS8:20 amKnoxville McGhee Tyson
8h 19m
2 stops
SAT3:39 pmSan Antonio
Jul 6
SAT5:23 pmSan Antonio
6h 12m
1 stop
TYS12:35 amKnoxville McGhee Tyson
$326

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 20, 2026.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 5/2

5:40 pm-11:10 pm

1 stop6h 30m

San Antonio

Sat 5/9

10:00 am-7:35 pm

1 stop8h 35m

$257

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 5/2

6:40 am-10:20 am

1 stop4h 40m

San Antonio

Sat 5/9

9:15 am-6:30 pm

2 stops8h 15m

$262

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 5/2

6:40 am-2:50 pm

2 stops9h 10m

San Antonio

Sat 5/9

9:15 am-6:30 pm

2 stops8h 15m

$267

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 4/30

4:09 pm-10:52 pm

1 stop7h 43m

San Antonio

Wed 5/6

6:20 am-3:45 pm

1 stop8h 25m

$274
Quickest round-trip

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 6/3

5:40 am-9:52 am

1 stop5h 12m

San Antonio

Sat 6/6

5:00 pm-12:01 am

1 stop6h 01m

$279

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 4/16

9:32 pm-11:51 pm

1 stop27h 19m

San Antonio

Thu 4/23

6:00 am-8:42 pm

1 stop13h 42m

$283

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Mon 4/6

9:00 am-9:27 am

1 stop25h 27m

San Antonio

Thu 4/9

10:22 am-10:05 pm

1 stop10h 43m

$285

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 4/23

6:54 pm-11:56 pm

1 stop6h 02m

San Antonio

Mon 4/27

5:42 pm-11:55 pm

1 stop5h 13m

$291

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Mon 4/13

1:15 pm-12:27 pm

1 stop24h 12m

San Antonio

Thu 4/16

6:00 am-2:45 pm

1 stop7h 45m

$294

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 6/3

5:20 pm-10:27 pm

1 stop6h 07m

San Antonio

Sat 6/6

5:00 pm-12:01 am

1 stop6h 01m

$297

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Knoxville to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of July, then book flights to San Antonio from Knoxville during September instead. Flights to San Antonio in September, while not as cheap as those in July, still average around $268.

How far in advance should I book a flight to San Antonio?

You are more likely to see cheaper flights to San Antonio from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $346 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Knoxville for as low as $243 on momondo.

How have Knoxville to San Antonio flight prices changed over time?

When to book flights from Knoxville to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Antonio (TYS to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Antonio

Fastest flight time

4h 45m

Direct flights

None
The fastest flight from Knoxville to San Antonio takes 4h 45m
There are no direct flights from Knoxville to San Antonio. There are no popular flight routes from Knoxville to San Antonio.
Search flight deals

  • How far is Knoxville McGhee Tyson to San Antonio by plane?

    San Antonio is 958.1 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 4h 45m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Antonio Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Antonio Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The required travel and health documents for your San Antonio Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Antonio Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Antonio?

Best airlines flying from Knoxville to San Antonio

Compare and see reviews for airlines that fly from Knoxville to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $207Free CancellationRating
7.9
8,302 reviews
Search Delta flights
American AirlinesPriceFrom $232Free CancellationRating
7.1
11,480 reviews
Search American Airlines flights
United AirlinesPriceFrom $236Free CancellationRating
7.4
9,450 reviews
Search United Airlines flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Pleasanton
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Antonio?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Antonio from Knoxville.

Can I find flights from Knoxville to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to San Antonio?

momondo helps you find the best flight between Knoxville and San Antonio by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to San Antonio right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Antonio from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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