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Cheap flights from Knoxville to San Antonio from $183

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Antonio departing on 8/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:00 pm - 10:43 pm
TYS
-
SAT
6h 43m
1 stop
Delta Logo
5:30 am - 11:18 am
SAT
-
TYS
4h 48m
1 stop
$295Delta
Sat, Sep 5 - Wed, Sep 16
Southwest Logo
12:45 pm - 5:35 pm
TYS
-
SAT
5h 50m
1 stop
Southwest Logo
1:20 pm - 8:25 pm
SAT
-
TYS
6h 05m
2 stops
$300Southwest
Tue, Jul 21 - Tue, Jul 28
Southwest Logo
12:45 pm - 11:00 pm
TYS
-
SAT
11h 15m
2 stops
Southwest Logo
12:00 pm - 8:25 pm
SAT
-
TYS
7h 25m
2 stops
$305Southwest
Tue, Jul 21 - Tue, Jul 28
Delta Logo
5:40 am - 11:10 am
TYS
-
SAT
6h 30m
1 stop
Delta Logo
5:20 am - 1:34 pm
SAT
-
TYS
7h 14m
1 stop
$312Delta
Tue, Aug 11 - Thu, Aug 13
Southwest Logo
7:00 am - 10:20 am
TYS
-
SAT
4h 20m
1 stop
Southwest Logo
7:10 am - 5:10 pm
SAT
-
TYS
9h 00m
2 stops
$317Southwest
Tue, Aug 11 - Thu, Aug 13
Multiple Airlines Logo
9:00 am - 11:21 am
TYS
-
SAT
27h 21m
2 stops
Multiple Airlines Logo
12:38 pm - 11:06 pm
SAT
-
TYS
9h 28m
1 stop
$322Multiple Airlines
Tue, Oct 13 - Fri, Oct 16
Multiple Airlines Logo
9:00 am - 9:39 am
TYS
-
SAT
25h 39m
1 stop
Multiple Airlines Logo
12:38 pm - 11:06 pm
SAT
-
TYS
9h 28m
1 stop
$326Multiple Airlines
Tue, Oct 13 - Fri, Oct 16
Southwest Logo
7:25 pm - 12:40 am
TYS
-
SAT
6h 15m
1 stop
Southwest Logo
11:55 am - 9:30 pm
SAT
-
TYS
8h 35m
1 stop
$329Southwest
Thu, Oct 22 - Mon, Oct 26
Southwest Logo
12:50 pm - 8:30 pm
TYS
-
SAT
8h 40m
2 stops
Southwest Logo
11:55 am - 9:30 pm
SAT
-
TYS
8h 35m
1 stop
$334Southwest
Thu, Oct 22 - Mon, Oct 26
Delta Logo
12:06 pm - 5:15 pm
TYS
-
SAT
6h 09m
1 stop
Delta Logo
6:22 pm - 11:59 pm
SAT
-
TYS
4h 37m
1 stop
$336Delta
Wed, Oct 21 - Sun, Oct 25

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Delta flights from Knoxville to San Antonio

Our best Delta deals on Knoxville to San Antonio flight tickets
Delta
Sep 5
TYS5:00 pmKnoxville McGhee Tyson
6h 43m
1 stop
SAT10:43 pmSan Antonio
Sep 16
SAT5:30 amSan Antonio
4h 48m
1 stop
TYS11:18 amKnoxville McGhee Tyson
$295
Delta
Aug 11
TYS5:40 amKnoxville McGhee Tyson
6h 30m
1 stop
SAT11:10 amSan Antonio
Aug 13
SAT5:20 amSan Antonio
7h 14m
1 stop
TYS1:34 pmKnoxville McGhee Tyson
$312
Delta
Oct 21
TYS12:06 pmKnoxville McGhee Tyson
6h 09m
1 stop
SAT5:15 pmSan Antonio
Oct 25
SAT6:22 pmSan Antonio
4h 37m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$336

Southwest flights from Knoxville to San Antonio

Our best Southwest deals on Knoxville to San Antonio flight tickets
Southwest
Aug 11
TYS7:00 amKnoxville McGhee Tyson
4h 20m
1 stop
SAT10:20 amSan Antonio
Aug 13
SAT7:10 amSan Antonio
9h 00m
2 stops
TYS5:10 pmKnoxville McGhee Tyson
$317
Southwest
Oct 22
TYS7:25 pmKnoxville McGhee Tyson
6h 15m
1 stop
SAT12:40 amSan Antonio
Oct 26
SAT11:55 amSan Antonio
8h 35m
1 stop
TYS9:30 pmKnoxville McGhee Tyson
$329
Southwest
Oct 22
TYS12:50 pmKnoxville McGhee Tyson
8h 40m
2 stops
SAT8:30 pmSan Antonio
Oct 26
SAT11:55 amSan Antonio
8h 35m
1 stop
TYS9:30 pmKnoxville McGhee Tyson
$334

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 5, 2026.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Sat 9/5

5:00 pm-10:43 pm

1 stop6h 43m

San Antonio

Wed 9/16

5:30 am-11:18 am

1 stop4h 48m

$295

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 7/21

12:45 pm-5:35 pm

1 stop5h 50m

San Antonio

Tue 7/28

1:20 pm-8:25 pm

2 stops6h 05m

$300

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 7/21

12:45 pm-11:00 pm

2 stops11h 15m

San Antonio

Tue 7/28

12:00 pm-8:25 pm

2 stops7h 25m

$305

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 8/11

5:40 am-11:10 am

1 stop6h 30m

San Antonio

Thu 8/13

5:20 am-1:34 pm

1 stop7h 14m

$312

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 8/11

7:00 am-10:20 am

1 stop4h 20m

San Antonio

Thu 8/13

7:10 am-5:10 pm

2 stops9h 00m

$317

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 10/13

9:00 am-11:21 am

2 stops27h 21m

San Antonio

Fri 10/16

12:38 pm-11:06 pm

1 stop9h 28m

$322

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 10/13

9:00 am-9:39 am

1 stop25h 39m

San Antonio

Fri 10/16

12:38 pm-11:06 pm

1 stop9h 28m

$326

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 10/22

7:25 pm-12:40 am

1 stop6h 15m

San Antonio

Mon 10/26

11:55 am-9:30 pm

1 stop8h 35m

$329

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 10/22

12:50 pm-8:30 pm

2 stops8h 40m

San Antonio

Mon 10/26

11:55 am-9:30 pm

1 stop8h 35m

$334
Quickest round-trip

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 10/21

12:06 pm-5:15 pm

1 stop6h 09m

San Antonio

Sun 10/25

6:22 pm-11:59 pm

1 stop4h 37m

$336

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Knoxville to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and San Antonio?

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of January, then book flights to San Antonio from Knoxville during April instead. Flights to San Antonio in April, while not as cheap as those in January, still average around $324.

How have Knoxville to San Antonio flight prices changed over time?

When to book flights from Knoxville to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Antonio (TYS to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Antonio

Fastest flight time

4h 58m

Direct flights

None
The fastest flight from Knoxville to San Antonio takes 4h 58m
There are no direct flights from Knoxville to San Antonio. There are no popular flight routes from Knoxville to San Antonio.
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Frequently asked questions about flying from Knoxville to San Antonio

  • How far is Knoxville McGhee Tyson to San Antonio by plane?

    San Antonio is 958.1 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 4h 58m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Antonio Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Antonio Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The required travel and health documents for your San Antonio Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Antonio Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Antonio?

Best airlines flying from Knoxville to San Antonio

Compare and see reviews for airlines that fly from Knoxville to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $236Free CancellationRating
7.4
9,933 reviews
Search United Airlines flights
DeltaPriceFrom $264Free CancellationRating
7.8
8,451 reviews
Search Delta flights
American AirlinesPriceFrom $268Free CancellationRating
7.1
11,777 reviews
Search American Airlines flights
SouthwestPriceFrom $299Free CancellationRating
7.9
4,249 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Pleasanton
Boerne
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Antonio?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Antonio from Knoxville.

Can I find flights from Knoxville to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to San Antonio?

momondo helps you find the best flight between Knoxville and San Antonio by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to San Antonio right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Antonio from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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