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Cheap flights from Des Moines to San Francisco from $101

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 3/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:32 pm - 12:28 am
DSM
-
SFO
6h 56m
1 stop
Frontier Logo
8:48 am - 6:42 pm
SFO
-
DSM
7h 54m
1 stop
$180Frontier
Thu, Feb 19 - Thu, Feb 26
Frontier Logo
7:17 pm - 10:01 pm
DSM
-
SFO
28h 44m
1 stop
Frontier Logo
6:00 am - 7:16 pm
SFO
-
DSM
11h 16m
1 stop
$195Frontier
Mon, Mar 2 - Mon, Mar 9
Frontier Logo
7:17 pm - 10:01 pm
DSM
-
SFO
28h 44m
1 stop
Frontier Logo
6:00 am - 7:16 pm
SFO
-
DSM
11h 16m
1 stop
$199Frontier
Mon, Mar 2 - Mon, Mar 9
Frontier Logo
7:17 pm - 10:01 pm
DSM
-
SFO
28h 44m
1 stop
Frontier Logo
6:00 am - 7:16 pm
SFO
-
DSM
11h 16m
1 stop
$200Frontier
Mon, Mar 2 - Mon, Mar 9
Frontier Logo
7:17 pm - 6:20 pm
DSM
-
SFO
25h 03m
2 stops
Frontier Logo
6:00 am - 7:16 pm
SFO
-
DSM
11h 16m
1 stop
$208Frontier
Mon, Mar 2 - Mon, Mar 9
Multiple Airlines Logo
8:29 pm - 6:20 pm
DSM
-
SFO
47h 51m
2 stops
Multiple Airlines Logo
6:00 am - 7:16 pm
SFO
-
DSM
11h 16m
1 stop
$209Multiple Airlines
Mon, Mar 2 - Mon, Mar 9
Multiple Airlines Logo
8:29 pm - 6:20 pm
DSM
-
SFO
47h 51m
2 stops
Multiple Airlines Logo
6:00 am - 7:16 pm
SFO
-
DSM
11h 16m
1 stop
$210Multiple Airlines
Mon, Mar 2 - Mon, Mar 9
Multiple Airlines Logo
8:21 pm - 8:09 pm
DSM
-
SFO
25h 48m
1 stop
Multiple Airlines Logo
5:47 pm - 3:01 pm
SFO
-
DSM
19h 14m
1 stop
$213Multiple Airlines
Mon, Mar 9 - Thu, Mar 12
Frontier Logo
8:21 pm - 12:29 am
DSM
-
SFO
6h 08m
1 stop
Frontier Logo
6:00 am - 7:16 pm
SFO
-
DSM
11h 16m
1 stop
$224Frontier
Mon, Mar 16 - Wed, Mar 25
Frontier Logo
7:17 pm - 6:20 pm
DSM
-
SFO
25h 03m
2 stops
Frontier Logo
6:00 am - 7:16 pm
SFO
-
DSM
11h 16m
1 stop
$229Frontier
Mon, Mar 2 - Mon, Mar 9

American Airlines flights from Des Moines to San Francisco

Our best American Airlines deals on Des Moines to San Francisco flight tickets
American Airlines
Feb 14
DSM10:04 amDes Moines
8h 39m
1 stop
SFO4:43 pmSan Francisco
Feb 21
SFO12:46 pmSan Francisco
9h 13m
1 stop
DSM11:59 pmDes Moines
$347
American Airlines
Apr 4
DSM2:28 pmDes Moines
10h 46m
1 stop
SFO11:14 pmSan Francisco
Apr 8
SFO6:00 amSan Francisco
8h 25m
1 stop
DSM4:25 pmDes Moines
$355
American Airlines
Jan 30
DSM4:00 pmDes Moines
8h 41m
2 stops
SFO10:41 pmSan Francisco
Feb 1
SFO6:42 amSan Francisco
6h 08m
1 stop
DSM2:50 pmDes Moines
$572

Frontier flights from Des Moines to San Francisco

Our best Frontier deals on Des Moines to San Francisco flight tickets
Frontier
Feb 19
DSM7:32 pmDes Moines
6h 56m
1 stop
SFO12:28 amSan Francisco
Feb 26
SFO8:48 amSan Francisco
7h 54m
1 stop
DSM6:42 pmDes Moines
$180
Frontier
Mar 2
DSM7:17 pmDes Moines
28h 44m
1 stop
SFO10:01 pmSan Francisco
Mar 9
SFO6:00 amSan Francisco
11h 16m
1 stop
DSM7:16 pmDes Moines
$195
Frontier
Mar 2
DSM7:17 pmDes Moines
28h 44m
1 stop
SFO10:01 pmSan Francisco
Mar 9
SFO6:00 amSan Francisco
11h 16m
1 stop
DSM7:16 pmDes Moines
$199

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 18, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 2/19

7:32 pm-12:28 am

1 stop6h 56m

San Francisco

Thu 2/26

8:48 am-6:42 pm

1 stop7h 54m

$180

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 3/2

7:17 pm-10:01 pm

1 stop28h 44m

San Francisco

Mon 3/9

6:00 am-7:16 pm

1 stop11h 16m

$195

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 3/2

7:17 pm-10:01 pm

1 stop28h 44m

San Francisco

Mon 3/9

6:00 am-7:16 pm

1 stop11h 16m

$199

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 3/2

7:17 pm-10:01 pm

1 stop28h 44m

San Francisco

Mon 3/9

6:00 am-7:16 pm

1 stop11h 16m

$200

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 3/2

7:17 pm-6:20 pm

2 stops25h 03m

San Francisco

Mon 3/9

6:00 am-7:16 pm

1 stop11h 16m

$208

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 3/2

8:29 pm-6:20 pm

2 stops47h 51m

San Francisco

Mon 3/9

6:00 am-7:16 pm

1 stop11h 16m

$209

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 3/2

8:29 pm-6:20 pm

2 stops47h 51m

San Francisco

Mon 3/9

6:00 am-7:16 pm

1 stop11h 16m

$210

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 3/9

8:21 pm-8:09 pm

1 stop25h 48m

San Francisco

Thu 3/12

5:47 pm-3:01 pm

1 stop19h 14m

$213

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 3/16

8:21 pm-12:29 am

1 stop6h 08m

San Francisco

Wed 3/25

6:00 am-7:16 pm

1 stop11h 16m

$224

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 3/2

7:17 pm-6:20 pm

2 stops25h 03m

San Francisco

Mon 3/9

6:00 am-7:16 pm

1 stop11h 16m

$229

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of September, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $374.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $430 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $383 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of January 2026, prices for Des Moines to San Francisco flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Fastest flight time

5h 40m

Direct flights

None
The fastest flight from Des Moines to San Francisco takes 5h 40m
There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.
Search flight deals

  • How far is Des Moines to San Francisco by plane?

    There are 1544.3 mi between Des Moines and San Francisco. Typically, this will take 5h 40m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

    Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

  • How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $110Free CancellationRating
5.7
3,057 reviews
Search Frontier flights
DeltaPriceFrom $263Free CancellationRating
7.9
8,074 reviews
Search Delta flights
SouthwestPriceFrom $336Free CancellationRating
8.0
4,261 reviews
Search Southwest flights
American AirlinesPriceFrom $336Free CancellationRating
7.2
11,156 reviews
Search American Airlines flights
United AirlinesPriceFrom $350Free CancellationRating
7.4
9,174 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Santa Clara
Berkeley
Walnut Creek
Fremont
Daly City
Half Moon Bay
Salinas
Vallejo
Livermore
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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