What is the cheapest airline that flies from Des Moines to San Francisco?

Frontier, American Airlines, and Delta are the most popular carriers operating from Des Moines to San Francisco

Which layover airport has the shortest connection time from Des Moines to San Francisco?

Minneapolis (MSP) has the shortest average layover time for this route: 0h 57m.

What day of the week experiences the fewest flight delays on this route?

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Wednesday has historically seen more delays on average compared to the rest of the week.

How often are flights from Des Moines to San Francisco delayed?

Historically, on average around 0% of flights between Des Moines and San Francisco have experienced a delay on any given week. The average delay length over the past 12 months has been 0 minutes.

Which layover airport offers the lowest fares from Des Moines to San Francisco?

Flights via Minneapolis (MSP) offer the lowest average round-trip price of $336.

What is the most punctual flight time for Des Moines to San Francisco flights?

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

What airlines fly to San Francisco?

American Airlines, Southwest and United Airlines are the top three most popular airlines that fly to San Francisco from Des Moines according to our data. American Airlines is the first choice among our users, with 33% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 5 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest travel time from Des Moines to San Francisco?

Flights connecting via Minneapolis (MSP) have the shortest average one-way travel time: 6h 04m.

Which airport is the most popular layover for flights between Des Moines and San Francisco?

Denver (DEN) was the most common stop: 63% of momondo users choosing 1-stop flights on this route connected there.

When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

The number of operators available for flights from Des Moines Airport to San Francisco Airport is 5 as of November 2025.

How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

What documentation or ID do you need to fly to San Francisco Airport?

The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$75 Cheap Flights from Des Moines to San Francisco in 2025/26

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7:36 pm - 12:25 amDSM-SFO

6h 49m1 stop

6:15 am - 6:46 pmSFO-DSM

10h 31m1 stop

$252Frontier

Find Deal

Thu, Mar 5 - Mon, Mar 9

2:34 pm - 12:14 amDSM-SFO

11h 40m1 stop

6:34 am - 1:47 pmSFO-DSM

5h 13m1 stop

$272Frontier

Find Deal

Fri, Nov 14 - Mon, Nov 17

8:00 am - 11:07 pmDSM-SFO

17h 07m2 stops

4:59 pm - 3:40 pmSFO-DSM

20h 41m1 stop

$273Multiple Airlines

Find Deal

Wed, Dec 17 - Thu, Jan 15

5:15 am - 9:52 amDSM-SFO

6h 37m1 stop

11:59 pm - 10:49 amSFO-DSM

8h 50m1 stop

$359American Airlines

Find Deal

Thu, Dec 18 - Thu, Dec 25

6:20 pm - 10:59 pmDSM-SFO

6h 39m1 stop

10:49 pm - 8:15 amSFO-DSM

7h 26m1 stop

$360American Airlines

Find Deal

Thu, Dec 18 - Thu, Dec 25

6:46 pm - 1:14 amDSM-SFO

8h 28m1 stop

1:19 pm - 10:30 pmSFO-DSM

7h 11m1 stop

$376United Airlines

Find Deal

Thu, Jan 1 - Sun, Jan 18

6:15 am - 1:55 pmDSM-SFO

9h 40m1 stop

12:10 pm - 9:20 pmSFO-DSM

7h 10m1 stop

$377Southwest

Find Deal

Tue, Dec 16 - Thu, Jan 15

11:01 am - 6:04 pmDSM-SFO

9h 03m1 stop

12:30 am - 10:21 amSFO-DSM

7h 51m1 stop

$382Delta

Find Deal

Sat, Dec 13 - Sun, Dec 14

8:20 am - 2:25 pmDSM-SFO

8h 05m2 stops

9:25 am - 9:35 pmSFO-DSM

10h 10m2 stops

$387Southwest

Find Deal

Thu, Dec 11 - Tue, Dec 16

6:45 am - 11:36 amDSM-SFO

6h 51m1 stop

12:40 am - 10:17 amSFO-DSM

7h 37m1 stop

$403Delta

Find Deal

Tue, Feb 17 - Fri, Mar 6

Frontier flights from Des Moines to San Francisco

Our best Frontier deals on Des Moines to San Francisco flight tickets

Frontier

Mar 5

DSM7:36 pmDes Moines

6h 49m

1 stop

SFO12:25 amSan Francisco

Mar 9

SFO6:15 amSan Francisco

10h 31m

1 stop

DSM6:46 pmDes Moines

$252

Find similar

Frontier

Nov 14

DSM2:34 pmDes Moines

11h 40m

1 stop

SFO12:14 amSan Francisco

Nov 17

SFO6:34 amSan Francisco

5h 13m

1 stop

DSM1:47 pmDes Moines

$272

Find similar

Frontier

Mar 6

DSM7:58 pmDes Moines

13h 55m

1 stop

SFO7:53 amSan Francisco

Mar 9

SFO6:15 amSan Francisco

10h 31m

1 stop

DSM6:46 pmDes Moines

$297

Find similar

United Airlines flights from Des Moines to San Francisco

Our best United Airlines deals on Des Moines to San Francisco flight tickets

United Airlines

Jan 1

DSM6:46 pmDes Moines

8h 28m

1 stop

SFO1:14 amSan Francisco

Jan 18

SFO1:19 pmSan Francisco

7h 11m

1 stop

DSM10:30 pmDes Moines

$376

Find similar

United Airlines

Nov 14

DSM6:05 amDes Moines

14h 42m

2 stops

SFO6:47 pmSan Francisco

Nov 17

SFO6:57 pmSan Francisco

19h 10m

2 stops

DSM4:07 pmDes Moines

$703

Find similar

United Airlines

Nov 18

DSM5:14 pmDes Moines

18h 21m

1 stop

SFO9:35 amSan Francisco

Nov 22

SFO2:49 pmSan Francisco

6h 55m

1 stop

DSM11:44 pmDes Moines

$705

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 3/5

7:36 pm-12:25 am

1 stop6h 49m

San Francisco

Mon 3/9

6:15 am-6:46 pm

1 stop10h 31m

$252

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 11/14

2:34 pm-12:14 am

1 stop11h 40m

San Francisco

Mon 11/17

6:34 am-1:47 pm

1 stop5h 13m

$272

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 12/17

8:00 am-11:07 pm

2 stops17h 07m

San Francisco

Thu 1/15

4:59 pm-3:40 pm

1 stop20h 41m

$273

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 12/18

5:15 am-9:52 am

1 stop6h 37m

San Francisco

Thu 12/25

11:59 pm-10:49 am

1 stop8h 50m

$359

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 12/18

6:20 pm-10:59 pm

1 stop6h 39m

San Francisco

Thu 12/25

10:49 pm-8:15 am

1 stop7h 26m

$360

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 1/1

6:46 pm-1:14 am

1 stop8h 28m

San Francisco

Sun 1/18

1:19 pm-10:30 pm

1 stop7h 11m

$376

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Tue 12/16

6:15 am-1:55 pm

1 stop9h 40m

San Francisco

Thu 1/15

12:10 pm-9:20 pm

1 stop7h 10m

$377

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sat 12/13

11:01 am-6:04 pm

1 stop9h 03m

San Francisco

Sun 12/14

12:30 am-10:21 am

1 stop7h 51m

$382

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 12/11

8:20 am-2:25 pm

2 stops8h 05m

San Francisco

Tue 12/16

9:25 am-9:35 pm

2 stops10h 10m

$387

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Tue 2/17

6:45 am-11:36 am

1 stop6h 51m

San Francisco

Fri 3/6

12:40 am-10:17 am

1 stop7h 37m

$403

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How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Delays

Layovers

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $368.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Des Moines to San Francisco is on a Friday when prices can be found for as low as $450. The most expensive day to fly to San Francisco is Sunday, with ticket prices averaging around $541.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Des Moines to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $371. Flights at noon are often more expensive with an average ticket price of $471.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $433 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $384 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of November 2025, prices for Des Moines to San Francisco flights are approximately 10% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Direct flights	None

There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.

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How far is Des Moines to San Francisco by plane?
There are 1544.3 mi between Des Moines and San Francisco. Typically, this will take 5h 55m by plane in normal conditions.
When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?
Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.
How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?
The number of operators available for flights from Des Moines Airport to San Francisco Airport is 5 as of November 2025.
How old do you have to be to fly from Des Moines Airport to San Francisco Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.
What documentation or ID do you need to fly to San Francisco Airport?
The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to San Francisco?
momondo data reveals that the most frequently booked airline on the route from Des Moines to San Francisco is American Airlines, representing 35% of all bookings. The subsequent popular airlines are United Airlines at 27%, Southwest at 19%, and Delta at 10%.

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo

Airline	Rating	Free Cancellation	Price
Frontier	PriceFrom $144	Free Cancellation	Rating 5.8 3,117 reviews	Search Frontier flights
Delta	PriceFrom $265	Free Cancellation	Rating 7.9 8,003 reviews	Search Delta flights
American Airlines	PriceFrom $336	Free Cancellation	Rating 7.2 11,040 reviews	Search American Airlines flights
Southwest	PriceFrom $344	Free Cancellation	Rating 8.0 4,239 reviews	Search Southwest flights
United Airlines	PriceFrom $353	Free Cancellation	Rating 7.4 9,002 reviews	Search United Airlines flights

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Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Cheap flights from Des Moines to San Francisco from $75

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 11/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Frontier flights from Des Moines to San Francisco

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Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

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How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $368.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Des Moines to San Francisco is on a Friday when prices can be found for as low as $450. The most expensive day to fly to San Francisco is Sunday, with ticket prices averaging around $541.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Des Moines to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $371. Flights at noon are often more expensive with an average ticket price of $471.

How far in advance should I book a flight to San Francisco?

How have Des Moines to San Francisco flight prices changed over time?

As of November 2025, prices for Des Moines to San Francisco flights are approximately 10% cheaper when compared to flights at the same time last year.

What is the cheapest airline that flies from Des Moines to San Francisco?

Frontier, American Airlines, and Delta are the most popular carriers operating from Des Moines to San Francisco

What airlines fly to San Francisco?

How often are flights from Des Moines to San Francisco delayed?

Historically, on average around 0% of flights between Des Moines and San Francisco have experienced a delay on any given week. The average delay length over the past 12 months has been 0 minutes.

What is the most punctual flight time for Des Moines to San Francisco flights?

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

What day of the week experiences the fewest flight delays on this route?

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Wednesday has historically seen more delays on average compared to the rest of the week.

Which airport is the most popular layover for flights between Des Moines and San Francisco?

Denver (DEN) was the most common stop: 63% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from Des Moines to San Francisco?

Flights via Minneapolis (MSP) offer the lowest average round-trip price of $336.

Which layover airport has the shortest travel time from Des Moines to San Francisco?

Flights connecting via Minneapolis (MSP) have the shortest average one-way travel time: 6h 04m.

Which layover airport has the shortest connection time from Des Moines to San Francisco?

Minneapolis (MSP) has the shortest average layover time for this route: 0h 57m.

When to book flights from Des Moines to San Francisco

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Direct flights

How far is Des Moines to San Francisco by plane?

When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

What documentation or ID do you need to fly to San Francisco Airport?

What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo

Traveling to a place near San Francisco?

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

How can momondo help me find flights from Des Moines to San Francisco?

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing California