Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to San Francisco from $98

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 10/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Des Moines to San Francisco

Cheap round-trip flights

Frontier Logo
2:32 pm - 12:14 amDSM-SFO
11h 42m1 stop
Frontier Logo
6:34 am - 1:47 pmSFO-DSM
5h 13m1 stop
$149Frontier
Find Deal
Fri, Nov 7 - Mon, Nov 10
Frontier Logo
2:25 pm - 12:16 amDSM-SFO
11h 51m1 stop
Frontier Logo
6:29 am - 1:40 pmSFO-DSM
5h 11m1 stop
$172Frontier
Find Deal
Thu, Oct 2 - Mon, Oct 6
Frontier Logo
2:25 pm - 8:15 amDSM-SFO
19h 50m1 stop
Frontier Logo
6:29 am - 1:40 pmSFO-DSM
5h 11m1 stop
$188Frontier
Find Deal
Thu, Sep 25 - Mon, Sep 29
Logo
7:30 am - 8:44 amDSM-SFO
27h 14m1 stop
Logo
6:29 am - 1:40 pmSFO-DSM
29h 11m1 stop
$263
Find Deal
Wed, Oct 1 - Sun, Oct 5
Logo
2:32 pm - 2:09 pmDSM-SFO
25h 37m2 stops
Logo
5:45 am - 10:40 pmSFO-DSM
14h 55m1 stop
$291
Find Deal
Thu, Nov 13 - Mon, Nov 17
Delta Logo
4:59 pm - 12:20 amDSM-SFO
9h 21m1 stop
Delta Logo
6:00 am - 5:03 pmSFO-DSM
9h 03m1 stop
$303Delta
Find Deal
Thu, Dec 11 - Sun, Dec 14
Delta Logo
5:47 am - 1:35 pmDSM-SFO
9h 48m1 stop
Delta Logo
6:10 am - 5:44 pmSFO-DSM
9h 34m1 stop
$337Delta
Find Deal
Tue, Oct 28 - Tue, Nov 4
American Airlines Logo
3:10 pm - 7:55 pmDSM-SFO
6h 45m1 stop
American Airlines Logo
8:00 am - 4:51 pmSFO-DSM
6h 51m1 stop
$338American Airlines
Find Deal
Tue, Oct 28 - Tue, Nov 4
American Airlines Logo
5:40 am - 11:26 amDSM-SFO
7h 46m1 stop
American Airlines Logo
6:00 am - 2:51 pmSFO-DSM
6h 51m1 stop
$339American Airlines
Find Deal
Tue, Dec 9 - Sat, Dec 13
United Airlines Logo
8:00 am - 5:42 pmDSM-SFO
11h 42m2 stops
United Airlines Logo
2:50 pm - 11:44 pmSFO-DSM
6h 54m1 stop
$355United Airlines
Find Deal
Thu, Dec 11 - Sat, Dec 13

Frontier flights from Des Moines to San Francisco

Our best Frontier deals on Des Moines to San Francisco flight tickets
Frontier
Nov 7
DSM2:32 pmDes Moines
11h 42m
1 stop
SFO12:14 amSan Francisco
Nov 10
SFO6:34 amSan Francisco
5h 13m
1 stop
DSM1:47 pmDes Moines
$149
Find similar
Frontier
Oct 2
DSM2:25 pmDes Moines
11h 51m
1 stop
SFO12:16 amSan Francisco
Oct 6
SFO6:29 amSan Francisco
5h 11m
1 stop
DSM1:40 pmDes Moines
$172
Find similar
Frontier
Sep 25
DSM2:25 pmDes Moines
19h 50m
1 stop
SFO8:15 amSan Francisco
Sep 29
SFO6:29 amSan Francisco
5h 11m
1 stop
DSM1:40 pmDes Moines
$188
Find similar

Delta flights from Des Moines to San Francisco

Our best Delta deals on Des Moines to San Francisco flight tickets
Delta
Dec 11
DSM4:59 pmDes Moines
9h 21m
1 stop
SFO12:20 amSan Francisco
Dec 14
SFO6:00 amSan Francisco
9h 03m
1 stop
DSM5:03 pmDes Moines
$303
Find similar
Delta
Oct 28
DSM5:47 amDes Moines
9h 48m
1 stop
SFO1:35 pmSan Francisco
Nov 4
SFO6:10 amSan Francisco
9h 34m
1 stop
DSM5:44 pmDes Moines
$337
Find similar
Delta
Sep 27
DSM3:00 pmDes Moines
9h 25m
1 stop
SFO10:25 pmSan Francisco
Sep 29
SFO12:45 amSan Francisco
7h 29m
1 stop
DSM10:14 amDes Moines
$547
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 11/7

2:32 pm-12:14 am

1 stop11h 42m

San Francisco

Mon 11/10

6:34 am-1:47 pm

1 stop5h 13m

$149

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 10/2

2:25 pm-12:16 am

1 stop11h 51m

San Francisco

Mon 10/6

6:29 am-1:40 pm

1 stop5h 11m

$172

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 9/25

2:25 pm-8:15 am

1 stop19h 50m

San Francisco

Mon 9/29

6:29 am-1:40 pm

1 stop5h 11m

$188

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 10/1

7:30 am-8:44 am

1 stop27h 14m

San Francisco

Sun 10/5

6:29 am-1:40 pm

1 stop29h 11m

$263

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 11/13

2:32 pm-2:09 pm

2 stops25h 37m

San Francisco

Mon 11/17

5:45 am-10:40 pm

1 stop14h 55m

$291

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 12/11

4:59 pm-12:20 am

1 stop9h 21m

San Francisco

Sun 12/14

6:00 am-5:03 pm

1 stop9h 03m

$303

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Tue 10/28

5:47 am-1:35 pm

1 stop9h 48m

San Francisco

Tue 11/4

6:10 am-5:44 pm

1 stop9h 34m

$337

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Tue 10/28

3:10 pm-7:55 pm

1 stop6h 45m

San Francisco

Tue 11/4

8:00 am-4:51 pm

1 stop6h 51m

$338

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Tue 12/9

5:40 am-11:26 am

1 stop7h 46m

San Francisco

Sat 12/13

6:00 am-2:51 pm

1 stop6h 51m

$339

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 12/11

8:00 am-5:42 pm

2 stops11h 42m

San Francisco

Sat 12/13

2:50 pm-11:44 pm

1 stop6h 54m

$355

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of September, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $367.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Des Moines to San Francisco is on a Friday when prices can be found for as low as $450. The most expensive day to fly to San Francisco is Sunday, with ticket prices averaging around $541.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Des Moines to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $371. Flights at noon are often more expensive with an average ticket price of $471.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $435 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $391 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of September 2025, prices for Des Moines to San Francisco flights are approximately 39% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Direct flights

None
There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.
Search flight deals

  • How far is Des Moines to San Francisco by plane?

    There are 1544.3 mi between Des Moines and San Francisco. Typically, this will take 6h 45m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

    Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

  • How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $118Free CancellationRating
5.8
3,172 reviews
Search Frontier flights
DeltaPriceFrom $265Free CancellationRating
7.9
7,954 reviews
Search Delta flights
American AirlinesPriceFrom $336Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $344Free CancellationRating
8.0
4,242 reviews
Search Southwest flights
United AirlinesPriceFrom $356Free CancellationRating
7.4
8,929 reviews
Search United Airlines flights

  • United Airlines Flights From Des Moines to San Francisco

    The lowest priced United Airlines flight from Des Moines to San Francisco from the last 72 hours was $356. Generally, United Airlines has 2 flights on this route every week with an average price of $516. United Airlines is rated 7.4/10 by our users.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Calistoga
Bodega Bay
Roseville
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Half Moon Bay
Walnut Creek
Vallejo
Redwood City
Salinas
South San Francisco
Fairfield

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 10/15
Wed 10/22
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States