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Cheap flights from Des Moines to San Francisco from $96

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:17 pm - 8:47 pm
DSM
-
SFO
26h 30m1 stop
Frontier Logo
8:58 am - 7:22 pm
SFO
-
DSM
8h 24m1 stop
$138Frontier
Fri, Jan 9 - Mon, Jan 12
Frontier Logo
8:17 pm - 8:47 pm
DSM
-
SFO
26h 30m1 stop
Frontier Logo
6:05 am - 7:22 pm
SFO
-
DSM
11h 17m1 stop
$139Frontier
Fri, Jan 9 - Mon, Jan 12
Frontier Logo
7:36 pm - 7:53 am
DSM
-
SFO
14h 17m1 stop
Frontier Logo
6:15 am - 6:41 pm
SFO
-
DSM
10h 26m1 stop
$166Frontier
Thu, Feb 12 - Thu, Feb 19
Frontier Logo
8:17 pm - 8:47 pm
DSM
-
SFO
26h 30m1 stop
Frontier Logo
8:58 am - 7:22 pm
SFO
-
DSM
8h 24m1 stop
$169Frontier
Fri, Jan 9 - Mon, Jan 12
Frontier Logo
8:17 pm - 9:46 am
DSM
-
SFO
39h 29m2 stops
Frontier Logo
8:58 am - 7:22 pm
SFO
-
DSM
8h 24m1 stop
$171Frontier
Fri, Jan 9 - Mon, Jan 12
Frontier Logo
8:17 pm - 9:46 am
DSM
-
SFO
39h 29m2 stops
Frontier Logo
8:58 am - 7:22 pm
SFO
-
DSM
8h 24m1 stop
$173Frontier
Fri, Jan 9 - Mon, Jan 12
Multiple Airlines Logo
7:00 am - 8:35 pm
DSM
-
SFO
15h 35m1 stop
Multiple Airlines Logo
2:08 pm - 10:09 pm
SFO
-
DSM
30h 01m2 stops
$176Multiple Airlines
Sun, Jan 18 - Wed, Jan 21
Frontier Logo
7:36 pm - 7:53 am
DSM
-
SFO
14h 17m1 stop
Frontier Logo
6:15 am - 6:41 pm
SFO
-
DSM
10h 26m1 stop
$183Frontier
Thu, Feb 12 - Thu, Feb 19
Multiple Airlines Logo
7:00 am - 8:35 pm
DSM
-
SFO
15h 35m1 stop
Multiple Airlines Logo
8:23 pm - 3:40 pm
SFO
-
DSM
17h 17m1 stop
$192Multiple Airlines
Sun, Jan 18 - Thu, Jan 22
Multiple Airlines Logo
8:18 pm - 8:46 pm
DSM
-
SFO
26h 28m1 stop
Multiple Airlines Logo
8:23 pm - 3:03 pm
SFO
-
DSM
40h 40m2 stops
$201Multiple Airlines
Fri, Jan 16 - Fri, Jan 23

American Airlines flights from Des Moines to San Francisco

Our best American Airlines deals on Des Moines to San Francisco flight tickets
American Airlines
Jan 6
DSM3:25 pmDes Moines
6h 45m
1 stop
SFO8:10 pmSan Francisco
Jan 10
SFO9:10 amSan Francisco
8h 54m
1 stop
DSM8:04 pmDes Moines
$229
Find similar
American Airlines
Jan 29
DSM11:35 amDes Moines
7h 49m
1 stop
SFO5:24 pmSan Francisco
Feb 10
SFO6:00 amSan Francisco
9h 06m
1 stop
DSM5:06 pmDes Moines
$235
Find similar
American Airlines
Jan 29
DSM4:00 pmDes Moines
8h 40m
2 stops
SFO10:40 pmSan Francisco
Feb 10
SFO7:00 amSan Francisco
8h 06m
1 stop
DSM5:06 pmDes Moines
$240
Find similar

Frontier flights from Des Moines to San Francisco

Our best Frontier deals on Des Moines to San Francisco flight tickets
Frontier
Jan 9
DSM8:17 pmDes Moines
26h 30m
1 stop
SFO8:47 pmSan Francisco
Jan 12
SFO8:58 amSan Francisco
8h 24m
1 stop
DSM7:22 pmDes Moines
$137
Find similar
Frontier
Jan 9
DSM8:17 pmDes Moines
26h 30m
1 stop
SFO8:47 pmSan Francisco
Jan 12
SFO8:58 amSan Francisco
8h 24m
1 stop
DSM7:22 pmDes Moines
$138
Find similar
Frontier
Jan 9
DSM8:17 pmDes Moines
26h 30m
1 stop
SFO8:47 pmSan Francisco
Jan 12
SFO6:05 amSan Francisco
11h 17m
1 stop
DSM7:22 pmDes Moines
$139
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 5, 2025.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 1/9

8:17 pm-8:47 pm

1 stop26h 30m

San Francisco

Mon 1/12

8:58 am-7:22 pm

1 stop8h 24m

$138

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 1/9

8:17 pm-8:47 pm

1 stop26h 30m

San Francisco

Mon 1/12

6:05 am-7:22 pm

1 stop11h 17m

$139

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 2/12

7:36 pm-7:53 am

1 stop14h 17m

San Francisco

Thu 2/19

6:15 am-6:41 pm

1 stop10h 26m

$166

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 1/9

8:17 pm-8:47 pm

1 stop26h 30m

San Francisco

Mon 1/12

8:58 am-7:22 pm

1 stop8h 24m

$169

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 1/9

8:17 pm-9:46 am

2 stops39h 29m

San Francisco

Mon 1/12

8:58 am-7:22 pm

1 stop8h 24m

$171

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 1/9

8:17 pm-9:46 am

2 stops39h 29m

San Francisco

Mon 1/12

8:58 am-7:22 pm

1 stop8h 24m

$173

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sun 1/18

7:00 am-8:35 pm

1 stop15h 35m

San Francisco

Wed 1/21

2:08 pm-10:09 pm

2 stops30h 01m

$176

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 2/12

7:36 pm-7:53 am

1 stop14h 17m

San Francisco

Thu 2/19

6:15 am-6:41 pm

1 stop10h 26m

$183

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sun 1/18

7:00 am-8:35 pm

1 stop15h 35m

San Francisco

Thu 1/22

8:23 pm-3:40 pm

1 stop17h 17m

$192

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 1/16

8:18 pm-8:46 pm

1 stop26h 28m

San Francisco

Fri 1/23

8:23 pm-3:03 pm

2 stops40h 40m

$201

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of September, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $374.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Des Moines to San Francisco is on a Friday when prices can be found for as low as $450. The most expensive day to fly to San Francisco is Sunday, with ticket prices averaging around $541.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Des Moines to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $371. Flights at noon are often more expensive with an average ticket price of $471.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $436 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $347 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of December 2025, prices for Des Moines to San Francisco flights are approximately 18% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Fastest flight time

5h 45m

Direct flights

None
The fastest flight from Des Moines to San Francisco takes 5h 45m
There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.
Search flight deals

  • How far is Des Moines to San Francisco by plane?

    There are 1544.3 mi between Des Moines and San Francisco. Typically, this will take 6h 23m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

    Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

  • How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $158Free CancellationRating
5.8
3,091 reviews
Search Frontier flights
DeltaPriceFrom $265Free CancellationRating
7.9
8,011 reviews
Search Delta flights
SouthwestPriceFrom $336Free CancellationRating
8.0
4,250 reviews
Search Southwest flights
American AirlinesPriceFrom $336Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights
United AirlinesPriceFrom $356Free CancellationRating
7.4
9,066 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Santa Clara
Berkeley
Walnut Creek
Daly City
Fremont
Half Moon Bay
Vallejo
Salinas
Livermore
Turlock
Sunnyvale

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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