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Cheap flights from Des Moines to San Francisco from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 11/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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Frontier Logo
2:32 pm - 12:14 amDSM-SFO
11h 42m1 stop
Frontier Logo
12:43 pm - 1:49 pmSFO-DSM
23h 06m1 stop
$131Frontier
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Mon, Nov 10 - Thu, Nov 13
Frontier Logo
2:32 pm - 12:14 amDSM-SFO
11h 42m1 stop
Frontier Logo
3:14 pm - 1:49 pmSFO-DSM
20h 35m2 stops
$170Frontier
Find Deal
Mon, Nov 10 - Thu, Nov 13
Delta Logo
10:21 am - 6:01 pmDSM-SFO
9h 40m1 stop
Delta Logo
5:50 am - 4:19 pmSFO-DSM
8h 29m1 stop
$322Delta
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Wed, Nov 19 - Mon, Nov 24
Delta Logo
6:50 am - 3:57 pmDSM-SFO
11h 07m2 stops
Delta Logo
5:50 am - 4:19 pmSFO-DSM
8h 29m1 stop
$352Delta
Find Deal
Wed, Nov 19 - Mon, Nov 24
American Airlines Logo
5:06 am - 4:01 pmDSM-SFO
12h 55m1 stop
American Airlines Logo
6:00 am - 4:41 pmSFO-DSM
8h 41m1 stop
$358American Airlines
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Wed, Nov 19 - Mon, Nov 24
United Airlines Logo
5:30 am - 9:45 amDSM-SFO
6h 15m1 stop
United Airlines Logo
11:15 pm - 10:55 amSFO-DSM
9h 40m1 stop
$359United Airlines
Find Deal
Wed, Feb 4 - Mon, Feb 9
American Airlines Logo
11:30 am - 7:02 pmDSM-SFO
9h 32m2 stops
American Airlines Logo
12:59 am - 10:40 amSFO-DSM
7h 41m1 stop
$364American Airlines
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Wed, Nov 19 - Sun, Nov 23
United Airlines Logo
2:52 pm - 9:13 pmDSM-SFO
8h 21m1 stop
United Airlines Logo
5:00 am - 12:38 pmSFO-DSM
5h 38m1 stop
$368United Airlines
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Sat, Nov 8 - Mon, Nov 10
Southwest Logo
3:35 pm - 7:50 pmDSM-SFO
6h 15m1 stop
Southwest Logo
10:45 am - 9:00 pmSFO-DSM
8h 15m2 stops
$373Southwest
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Sat, Nov 8 - Mon, Nov 10
Southwest Logo
5:25 am - 1:40 pmDSM-SFO
10h 15m2 stops
Southwest Logo
9:25 am - 9:00 pmSFO-DSM
9h 35m2 stops
$378Southwest
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Sat, Nov 8 - Mon, Nov 10

Delta flights from Des Moines to San Francisco

Our best Delta deals on Des Moines to San Francisco flight tickets
Delta
Nov 19
DSM10:21 amDes Moines
9h 40m
1 stop
SFO6:01 pmSan Francisco
Nov 24
SFO5:50 amSan Francisco
8h 29m
1 stop
DSM4:19 pmDes Moines
$322
Find similar
Delta
Nov 19
DSM6:50 amDes Moines
11h 07m
2 stops
SFO3:57 pmSan Francisco
Nov 24
SFO5:50 amSan Francisco
8h 29m
1 stop
DSM4:19 pmDes Moines
$352
Find similar
Delta
Nov 19
DSM2:17 pmDes Moines
11h 06m
1 stop
SFO11:23 pmSan Francisco
Nov 24
SFO7:37 pmSan Francisco
12h 43m
2 stops
DSM10:20 amDes Moines
$354
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United Airlines flights from Des Moines to San Francisco

Our best United Airlines deals on Des Moines to San Francisco flight tickets
United Airlines
Feb 4
DSM5:30 amDes Moines
6h 15m
1 stop
SFO9:45 amSan Francisco
Feb 9
SFO11:15 pmSan Francisco
9h 40m
1 stop
DSM10:55 amDes Moines
$359
Find similar
United Airlines
Nov 8
DSM2:52 pmDes Moines
8h 21m
1 stop
SFO9:13 pmSan Francisco
Nov 10
SFO5:00 amSan Francisco
5h 38m
1 stop
DSM12:38 pmDes Moines
$368
Find similar
United Airlines
Oct 25
DSM6:15 amDes Moines
8h 04m
1 stop
SFO12:19 pmSan Francisco
Oct 31
SFO4:28 pmSan Francisco
5h 14m
1 stop
DSM11:42 pmDes Moines
$606
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 11/10

2:32 pm-12:14 am

1 stop11h 42m

San Francisco

Thu 11/13

12:43 pm-1:49 pm

1 stop23h 06m

$131

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 11/10

2:32 pm-12:14 am

1 stop11h 42m

San Francisco

Thu 11/13

3:14 pm-1:49 pm

2 stops20h 35m

$170

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 11/19

10:21 am-6:01 pm

1 stop9h 40m

San Francisco

Mon 11/24

5:50 am-4:19 pm

1 stop8h 29m

$322

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 11/19

6:50 am-3:57 pm

2 stops11h 07m

San Francisco

Mon 11/24

5:50 am-4:19 pm

1 stop8h 29m

$352

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 11/19

5:06 am-4:01 pm

1 stop12h 55m

San Francisco

Mon 11/24

6:00 am-4:41 pm

1 stop8h 41m

$358

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 2/4

5:30 am-9:45 am

1 stop6h 15m

San Francisco

Mon 2/9

11:15 pm-10:55 am

1 stop9h 40m

$359

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 11/19

11:30 am-7:02 pm

2 stops9h 32m

San Francisco

Sun 11/23

12:59 am-10:40 am

1 stop7h 41m

$364

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sat 11/8

2:52 pm-9:13 pm

1 stop8h 21m

San Francisco

Mon 11/10

5:00 am-12:38 pm

1 stop5h 38m

$368

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sat 11/8

3:35 pm-7:50 pm

1 stop6h 15m

San Francisco

Mon 11/10

10:45 am-9:00 pm

2 stops8h 15m

$373

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sat 11/8

5:25 am-1:40 pm

2 stops10h 15m

San Francisco

Mon 11/10

9:25 am-9:00 pm

2 stops9h 35m

$378

Flights are sorted by cheapest round-trip flights first.

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See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $368.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Des Moines to San Francisco is on a Friday when prices can be found for as low as $450. The most expensive day to fly to San Francisco is Sunday, with ticket prices averaging around $541.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Des Moines to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $371. Flights at noon are often more expensive with an average ticket price of $471.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $436 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $384 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of October 2025, prices for Des Moines to San Francisco flights are approximately 9% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Direct flights

None
There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.
Search flight deals

  • How far is Des Moines to San Francisco by plane?

    There are 1544.3 mi between Des Moines and San Francisco. Typically, this will take 6h 15m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

    Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

  • How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $118Free CancellationRating
5.8
3,137 reviews
Search Frontier flights
DeltaPriceFrom $265Free CancellationRating
7.9
7,984 reviews
Search Delta flights
American AirlinesPriceFrom $336Free CancellationRating
7.2
11,043 reviews
Search American Airlines flights
SouthwestPriceFrom $344Free CancellationRating
8.0
4,241 reviews
Search Southwest flights
United AirlinesPriceFrom $353Free CancellationRating
7.4
8,982 reviews
Search United Airlines flights

  • United Airlines Flights From Des Moines to San Francisco

    The lowest priced United Airlines flight from Des Moines to San Francisco from the last 72 hours was $353. Generally, United Airlines has 4 flights on this route every week with an average price of $513. United Airlines is rated 7.4/10 by our users.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Calistoga
Roseville
Hayward
Big Sur
Santa Clara
Fremont
Daly City
Berkeley
Vallejo
Walnut Creek
Half Moon Bay
Salinas
Turlock
South San Francisco
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your San Francisco trip

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