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Cheap flights from Des Moines to San Francisco from $106

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 4/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Des Moines to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
$185Frontier
Wed, May 6 - Wed, May 13
Frontier Logo
8:23 pm - 11:42 am
DSM
-
SFO
17h 19m
1 stop
Frontier Logo
12:52 pm - 1:31 pm
SFO
-
DSM
22h 39m
1 stop
$186Frontier
Mon, May 4 - Tue, May 12
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
$210Frontier
Wed, May 27 - Mon, Jun 1
Frontier Logo
2:16 pm - 8:01 am
DSM
-
SFO
19h 45m
1 stop
Frontier Logo
12:52 pm - 1:31 pm
SFO
-
DSM
22h 39m
1 stop
$221Frontier
Fri, May 29 - Tue, Jun 2
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
$225Frontier
Wed, May 13 - Mon, May 18
Frontier Logo
2:04 pm - 12:27 am
DSM
-
SFO
12h 23m
1 stop
Frontier Logo
6:00 am - 7:38 pm
SFO
-
DSM
11h 38m
1 stop
$230Frontier
Fri, May 1 - Mon, May 4
Frontier Logo
2:04 pm - 12:27 am
DSM
-
SFO
12h 23m
1 stop
Frontier Logo
11:56 am - 1:09 pm
SFO
-
DSM
23h 13m
1 stop
$236Frontier
Mon, Apr 20 - Thu, Apr 30
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
Frontier Logo
12:52 pm - 1:31 pm
SFO
-
DSM
22h 39m
1 stop
$241Frontier
Wed, May 20 - Tue, May 26
Frontier Logo
2:16 pm - 12:22 am
DSM
-
SFO
12h 06m
1 stop
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
$250Frontier
Wed, Jul 8 - Mon, Jul 13
Frontier Logo
2:04 pm - 12:27 am
DSM
-
SFO
12h 23m
1 stop
Frontier Logo
12:52 pm - 1:31 pm
SFO
-
DSM
22h 39m
1 stop
$261Frontier
Fri, May 1 - Thu, May 7

American Airlines flights from Des Moines to San Francisco

Our best American Airlines deals on Des Moines to San Francisco flight tickets
American Airlines
Apr 4
DSM2:28 pmDes Moines
10h 46m
1 stop
SFO11:14 pmSan Francisco
Apr 11
SFO9:00 amSan Francisco
12h 56m
1 stop
DSM11:56 pmDes Moines
$678
American Airlines
Apr 8
DSM2:38 pmDes Moines
9h 58m
1 stop
SFO10:36 pmSan Francisco
Apr 12
SFO7:10 amSan Francisco
9h 15m
1 stop
DSM6:25 pmDes Moines
$680
American Airlines
Apr 9
DSM5:25 amDes Moines
12h 00m
1 stop
SFO3:25 pmSan Francisco
Apr 13
SFO10:13 amSan Francisco
6h 12m
1 stop
DSM6:25 pmDes Moines
$720

United Airlines flights from Des Moines to San Francisco

Our best United Airlines deals on Des Moines to San Francisco flight tickets
United Airlines
Apr 15
DSM8:04 amDes Moines
7h 08m
1 stop
SFO1:12 pmSan Francisco
Apr 19
SFO5:00 amSan Francisco
5h 47m
1 stop
DSM12:47 pmDes Moines
$563
United Airlines
Apr 13
DSM7:16 pmDes Moines
7h 23m
1 stop
SFO12:39 amSan Francisco
Apr 15
SFO12:45 amSan Francisco
9h 44m
1 stop
DSM12:29 pmDes Moines
$687
United Airlines
Apr 4
DSM9:00 amDes Moines
11h 57m
2 stops
SFO6:57 pmSan Francisco
Apr 11
SFO10:50 pmSan Francisco
9h 54m
1 stop
DSM10:44 amDes Moines
$750

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 2, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 5/6

2:16 pm-12:23 am

1 stop12h 07m

San Francisco

Wed 5/13

6:00 am-1:31 pm

1 stop5h 31m

$185

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 5/4

8:23 pm-11:42 am

1 stop17h 19m

San Francisco

Tue 5/12

12:52 pm-1:31 pm

1 stop22h 39m

$186

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 5/27

2:16 pm-12:23 am

1 stop12h 07m

San Francisco

Mon 6/1

6:00 am-1:31 pm

1 stop5h 31m

$210

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 5/29

2:16 pm-8:01 am

1 stop19h 45m

San Francisco

Tue 6/2

12:52 pm-1:31 pm

1 stop22h 39m

$221

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 5/13

2:16 pm-12:23 am

1 stop12h 07m

San Francisco

Mon 5/18

6:00 am-1:31 pm

1 stop5h 31m

$225

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 5/1

2:04 pm-12:27 am

1 stop12h 23m

San Francisco

Mon 5/4

6:00 am-7:38 pm

1 stop11h 38m

$230

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 4/20

2:04 pm-12:27 am

1 stop12h 23m

San Francisco

Thu 4/30

11:56 am-1:09 pm

1 stop23h 13m

$236

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 5/20

2:16 pm-12:23 am

1 stop12h 07m

San Francisco

Tue 5/26

12:52 pm-1:31 pm

1 stop22h 39m

$241
Quickest round-trip

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 7/8

2:16 pm-12:22 am

1 stop12h 06m

San Francisco

Mon 7/13

6:00 am-1:31 pm

1 stop5h 31m

$250

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 5/1

2:04 pm-12:27 am

1 stop12h 23m

San Francisco

Thu 5/7

12:52 pm-1:31 pm

1 stop22h 39m

$261

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of February, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $366.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $427 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $351 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of April 2026, prices for Des Moines to San Francisco flights are approximately 5% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Fastest flight time

5h 25m

Direct flights

None
The fastest flight from Des Moines to San Francisco takes 5h 25m
There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.
Search flight deals

Frequently asked questions about flying from Des Moines to San Francisco

  • How far is Des Moines to San Francisco by plane?

    There are 1543.9 mi between Des Moines and San Francisco. Typically, this will take 5h 25m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

    Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

  • How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $158Free CancellationRating
5.7
3,004 reviews
Search Frontier flights
DeltaPriceFrom $265Free CancellationRating
7.9
8,370 reviews
Search Delta flights
American AirlinesPriceFrom $334Free CancellationRating
7.1
11,549 reviews
Search American Airlines flights
SouthwestPriceFrom $336Free CancellationRating
8.0
4,337 reviews
Search Southwest flights
United AirlinesPriceFrom $342Free CancellationRating
7.4
9,533 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Roseville
Hayward
Berkeley
Santa Clara
Big Sur
Fremont
Vallejo
Calistoga
Salinas
Daly City
Half Moon Bay
Milpitas
South San Francisco
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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