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Cheap flights from Des Moines to San Francisco from $122

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 8/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:06 pm - 9:12 pm
DSM
-
SFO
25h 06m
1 stop
Multiple Airlines Logo
8:56 pm - 9:00 pm
SFO
-
DSM
22h 04m
1 stop
$180Multiple Airlines
Mon, Aug 10 - Wed, Aug 26
Multiple Airlines Logo
10:06 pm - 3:20 pm
DSM
-
SFO
19h 14m
1 stop
Multiple Airlines Logo
8:56 pm - 9:00 pm
SFO
-
DSM
22h 04m
1 stop
$185Multiple Airlines
Mon, Aug 10 - Wed, Aug 19
Multiple Airlines Logo
8:38 pm - 10:25 am
DSM
-
SFO
15h 47m
1 stop
Multiple Airlines Logo
8:56 pm - 9:00 pm
SFO
-
DSM
22h 04m
1 stop
$189Multiple Airlines
Mon, Aug 24 - Wed, Aug 26
Multiple Airlines Logo
7:38 pm - 8:43 am
DSM
-
SFO
15h 05m
1 stop
Multiple Airlines Logo
8:56 pm - 9:00 pm
SFO
-
DSM
22h 04m
1 stop
$196Multiple Airlines
Fri, Aug 21 - Wed, Aug 26
Multiple Airlines Logo
10:06 pm - 8:40 pm
DSM
-
SFO
24h 34m
2 stops
Multiple Airlines Logo
8:56 pm - 9:00 pm
SFO
-
DSM
22h 04m
1 stop
$202Multiple Airlines
Mon, Aug 10 - Wed, Aug 26
Multiple Airlines Logo
9:50 pm - 8:43 am
DSM
-
SFO
12h 53m
1 stop
Multiple Airlines Logo
8:56 pm - 9:00 pm
SFO
-
DSM
22h 04m
1 stop
$203Multiple Airlines
Sun, Aug 23 - Wed, Aug 26
Multiple Airlines Logo
10:06 pm - 4:36 pm
DSM
-
SFO
20h 30m
1 stop
Multiple Airlines Logo
8:56 pm - 9:00 pm
SFO
-
DSM
22h 04m
1 stop
$207Multiple Airlines
Fri, Aug 14 - Wed, Aug 19
Multiple Airlines Logo
10:06 pm - 8:40 pm
DSM
-
SFO
24h 34m
2 stops
Multiple Airlines Logo
8:56 pm - 9:00 pm
SFO
-
DSM
22h 04m
1 stop
$217Multiple Airlines
Mon, Aug 17 - Wed, Aug 26
Multiple Airlines Logo
9:31 pm - 11:45 pm
DSM
-
SFO
28h 14m
1 stop
Multiple Airlines Logo
6:30 am - 7:48 pm
SFO
-
DSM
11h 18m
1 stop
$221Multiple Airlines
Mon, Sep 14 - Fri, Sep 18
Multiple Airlines Logo
7:38 pm - 8:43 am
DSM
-
SFO
15h 05m
1 stop
Multiple Airlines Logo
8:56 pm - 9:00 pm
SFO
-
DSM
22h 04m
1 stop
$224Multiple Airlines
Fri, Aug 21 - Sat, Aug 22

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Frontier flights from Des Moines to San Francisco

Our best Frontier deals on Des Moines to San Francisco flight tickets
Frontier
Aug 5
DSM2:19 pmDes Moines
11h 59m
1 stop
SFO12:18 amSan Francisco
Aug 12
SFO6:00 amSan Francisco
5h 34m
1 stop
DSM1:34 pmDes Moines
$262
Frontier
Aug 5
DSM2:19 pmDes Moines
11h 59m
1 stop
SFO12:18 amSan Francisco
Aug 12
SFO6:00 amSan Francisco
5h 34m
1 stop
DSM1:34 pmDes Moines
$263
Frontier
Aug 5
DSM2:19 pmDes Moines
11h 59m
1 stop
SFO12:18 amSan Francisco
Aug 10
SFO6:00 amSan Francisco
5h 34m
1 stop
DSM1:34 pmDes Moines
$270

Southwest flights from Des Moines to San Francisco

Our best Southwest deals on Des Moines to San Francisco flight tickets
Southwest
Jul 14
DSM6:25 amDes Moines
5h 25m
1 stop
SFO9:50 amSan Francisco
Jul 17
SFO12:00 pmSan Francisco
8h 25m
2 stops
DSM10:25 pmDes Moines
$568
Southwest
Jul 13
DSM6:10 amDes Moines
7h 50m
2 stops
SFO12:00 pmSan Francisco
Jul 19
SFO6:25 amSan Francisco
9h 05m
2 stops
DSM5:30 pmDes Moines
$573
Southwest
Jul 11
DSM3:35 pmDes Moines
10h 00m
1 stop
SFO11:35 pmSan Francisco
Jul 12
SFO12:40 pmSan Francisco
7h 55m
2 stops
DSM10:35 pmDes Moines
$592

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 30, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 8/10

10:06 pm-9:12 pm

1 stop25h 06m

San Francisco

Wed 8/26

8:56 pm-9:00 pm

1 stop22h 04m

$180

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 8/10

10:06 pm-3:20 pm

1 stop19h 14m

San Francisco

Wed 8/19

8:56 pm-9:00 pm

1 stop22h 04m

$185

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 8/24

8:38 pm-10:25 am

1 stop15h 47m

San Francisco

Wed 8/26

8:56 pm-9:00 pm

1 stop22h 04m

$189

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 8/21

7:38 pm-8:43 am

1 stop15h 05m

San Francisco

Wed 8/26

8:56 pm-9:00 pm

1 stop22h 04m

$196

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 8/10

10:06 pm-8:40 pm

2 stops24h 34m

San Francisco

Wed 8/26

8:56 pm-9:00 pm

1 stop22h 04m

$202
Quickest round-trip

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sun 8/23

9:50 pm-8:43 am

1 stop12h 53m

San Francisco

Wed 8/26

8:56 pm-9:00 pm

1 stop22h 04m

$203

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 8/14

10:06 pm-4:36 pm

1 stop20h 30m

San Francisco

Wed 8/19

8:56 pm-9:00 pm

1 stop22h 04m

$207

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 8/17

10:06 pm-8:40 pm

2 stops24h 34m

San Francisco

Wed 8/26

8:56 pm-9:00 pm

1 stop22h 04m

$217

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 9/14

9:31 pm-11:45 pm

1 stop28h 14m

San Francisco

Fri 9/18

6:30 am-7:48 pm

1 stop11h 18m

$221

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 8/21

7:38 pm-8:43 am

1 stop15h 05m

San Francisco

Sat 8/22

8:56 pm-9:00 pm

1 stop22h 04m

$224

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of September, then flying in February is also cheap. Prices for this month can be found on momondo for an average of $367.

How far in advance should I book a flight from Des Moines to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $453 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $354 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of June 2026, prices for Des Moines to San Francisco flights are approximately 7% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Fastest flight time

5h 30m

Direct flights

None
The fastest flight from Des Moines to San Francisco takes 5h 30m
There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.
Search flight deals

Frequently asked questions about flying from Des Moines to San Francisco

  • How far is Des Moines to San Francisco by plane?

    There are 1543.9 mi between Des Moines and San Francisco. Typically, this will take 5h 30m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

    Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

  • How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $120Free CancellationRating
5.6
2,851 reviews
Search Frontier flights
DeltaPriceFrom $263Free CancellationRating
7.8
8,451 reviews
Search Delta flights
United AirlinesPriceFrom $321Free CancellationRating
7.4
9,901 reviews
Search United Airlines flights
American AirlinesPriceFrom $336Free CancellationRating
7.1
11,762 reviews
Search American Airlines flights
SouthwestPriceFrom $371Free CancellationRating
7.9
4,247 reviews
Search Southwest flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Bodega Bay
South San Francisco
Sonoma
Fremont
Hayward
Roseville
Walnut Creek
Santa Clara
Berkeley
Vallejo
Salinas
Sunnyvale
Big Sur
Burlingame
Daly City
Milpitas
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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