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Cheap flights from Des Moines to San Francisco from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 10/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to San Francisco

Cheap round-trip flights

Frontier Logo
2:25 pm - 8:15 amDSM-SFO
19h 50m1 stop
Frontier Logo
6:29 am - 1:40 pmSFO-DSM
5h 11m1 stop
$149Frontier
Find Deal
Thu, Sep 18 - Mon, Sep 22
Frontier Logo
2:25 pm - 12:16 amDSM-SFO
11h 51m1 stop
Frontier Logo
6:29 am - 1:40 pmSFO-DSM
5h 11m1 stop
$178Frontier
Find Deal
Thu, Sep 25 - Mon, Sep 29
Logo
7:30 am - 8:44 amDSM-SFO
27h 14m1 stop
Logo
8:00 am - 3:44 pmSFO-DSM
29h 44m2 stops
$247
Find Deal
Wed, Oct 8 - Wed, Oct 15
Logo
7:30 am - 9:22 pmDSM-SFO
15h 52m1 stop
Logo
8:00 am - 3:44 pmSFO-DSM
29h 44m2 stops
$254
Find Deal
Wed, Oct 8 - Wed, Oct 15
Delta Logo
2:40 pm - 8:40 pmDSM-SFO
8h 00m1 stop
Delta Logo
12:35 am - 10:26 amSFO-DSM
7h 51m1 stop
$295Delta
Find Deal
Wed, Oct 8 - Tue, Oct 14
American Airlines Logo
6:44 am - 2:48 pmDSM-SFO
10h 04m1 stop
American Airlines Logo
8:00 am - 5:37 pmSFO-DSM
7h 37m1 stop
$304American Airlines
Find Deal
Sat, Oct 18 - Tue, Oct 21
American Airlines Logo
11:30 am - 7:02 pmDSM-SFO
9h 32m2 stops
American Airlines Logo
9:15 am - 5:31 pmSFO-DSM
6h 16m1 stop
$309American Airlines
Find Deal
Wed, Nov 19 - Mon, Nov 24
Delta Logo
12:30 pm - 5:51 pmDSM-SFO
7h 21m1 stop
Delta Logo
5:55 am - 4:52 pmSFO-DSM
8h 57m1 stop
$313Delta
Find Deal
Sat, Oct 11 - Sat, Oct 18
Southwest Logo
6:10 am - 1:35 pmDSM-SFO
9h 25m1 stop
Southwest Logo
1:00 pm - 11:35 pmSFO-DSM
8h 35m1 stop
$341Southwest
Find Deal
Tue, Feb 10 - Fri, Feb 13
Southwest Logo
8:35 am - 2:35 pmDSM-SFO
8h 00m2 stops
Southwest Logo
1:00 pm - 11:35 pmSFO-DSM
8h 35m1 stop
$346Southwest
Find Deal
Tue, Feb 10 - Fri, Feb 13

Frontier flights from Des Moines to San Francisco

Our best Frontier deals on Des Moines to San Francisco flight tickets
Frontier
Sep 18
DSM2:25 pmDes Moines
19h 50m
1 stop
SFO8:15 amSan Francisco
Sep 22
SFO6:29 amSan Francisco
5h 11m
1 stop
DSM1:40 pmDes Moines
$149
Find similar
Frontier
Sep 25
DSM2:25 pmDes Moines
11h 51m
1 stop
SFO12:16 amSan Francisco
Sep 29
SFO6:29 amSan Francisco
5h 11m
1 stop
DSM1:40 pmDes Moines
$178
Find similar
Frontier
Oct 8
DSM2:37 pmDes Moines
9h 50m
1 stop
SFO10:27 pmSan Francisco
Oct 15
SFO6:34 amSan Francisco
5h 18m
1 stop
DSM1:52 pmDes Moines
$182
Find similar

United Airlines flights from Des Moines to San Francisco

Our best United Airlines deals on Des Moines to San Francisco flight tickets
United Airlines
Aug 30
DSM8:00 amDes Moines
25h 25m
2 stops
SFO7:25 amSan Francisco
Sep 30
SFO11:00 pmSan Francisco
9h 32m
1 stop
DSM10:32 amDes Moines
$515
Find similar
United Airlines
Aug 30
DSM9:23 amDes Moines
11h 42m
2 stops
SFO7:05 pmSan Francisco
Sep 30
SFO7:00 amSan Francisco
11h 18m
2 stops
DSM8:18 pmDes Moines
$560
Find similar
United Airlines
Aug 30
DSM8:00 amDes Moines
17h 10m
2 stops
SFO11:10 pmSan Francisco
Aug 31
SFO9:01 amSan Francisco
12h 40m
2 stops
DSM11:41 pmDes Moines
$649
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 29, 2025.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 9/18

2:25 pm-8:15 am

1 stop19h 50m

San Francisco

Mon 9/22

6:29 am-1:40 pm

1 stop5h 11m

$149

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 9/25

2:25 pm-12:16 am

1 stop11h 51m

San Francisco

Mon 9/29

6:29 am-1:40 pm

1 stop5h 11m

$178

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 10/8

7:30 am-8:44 am

1 stop27h 14m

San Francisco

Wed 10/15

8:00 am-3:44 pm

2 stops29h 44m

$247

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 10/8

7:30 am-9:22 pm

1 stop15h 52m

San Francisco

Wed 10/15

8:00 am-3:44 pm

2 stops29h 44m

$254

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 10/8

2:40 pm-8:40 pm

1 stop8h 00m

San Francisco

Tue 10/14

12:35 am-10:26 am

1 stop7h 51m

$295

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sat 10/18

6:44 am-2:48 pm

1 stop10h 04m

San Francisco

Tue 10/21

8:00 am-5:37 pm

1 stop7h 37m

$304

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 11/19

11:30 am-7:02 pm

2 stops9h 32m

San Francisco

Mon 11/24

9:15 am-5:31 pm

1 stop6h 16m

$309

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sat 10/11

12:30 pm-5:51 pm

1 stop7h 21m

San Francisco

Sat 10/18

5:55 am-4:52 pm

1 stop8h 57m

$313

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Tue 2/10

6:10 am-1:35 pm

1 stop9h 25m

San Francisco

Fri 2/13

1:00 pm-11:35 pm

1 stop8h 35m

$341

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Tue 2/10

8:35 am-2:35 pm

2 stops8h 00m

San Francisco

Fri 2/13

1:00 pm-11:35 pm

1 stop8h 35m

$346

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of August, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $386.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Des Moines to San Francisco is on a Friday when prices can be found for as low as $450. The most expensive day to fly to San Francisco is Sunday, with ticket prices averaging around $541.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Des Moines to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $371. Flights at noon are often more expensive with an average ticket price of $471.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $437 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $379 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of August 2025, prices for Des Moines to San Francisco flights are approximately 37% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Direct flights

None
There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.
Search flight deals

  • How far is Des Moines to San Francisco by plane?

    There are 1544.3 mi between Des Moines and San Francisco. Typically, this will take 6h 54m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

    Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

  • How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $110Free CancellationRating
5.8
3,204 reviews
Search Frontier flights
DeltaPriceFrom $265Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $336Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $350Free CancellationRating
8.0
4,242 reviews
Search Southwest flights
United AirlinesPriceFrom $356Free CancellationRating
7.4
8,944 reviews
Search United Airlines flights

  • United Airlines Flights From Des Moines to San Francisco

    The lowest priced United Airlines flight from Des Moines to San Francisco from the last 72 hours was $356. Generally, United Airlines has 2 flights on this route every week with an average price of $514. United Airlines is rated 7.4/10 by our users.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Calistoga
Hayward
Bodega Bay
Roseville
Santa Clara
Big Sur
Daly City
Fremont
Berkeley
Walnut Creek
Half Moon Bay
South San Francisco
Vallejo
Redwood City
Pacific Grove
Salinas

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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