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Cheap flights from Des Moines to San Francisco from $96

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:04 pm - 8:19 amDSM  Des Moines-SFO San Francisco
14h 15m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
10:35 am - 10:26 pmSFO  San Francisco-DSM Des Moines
9h 51m1 stop Las Vegas Harry Reid Intl
$191Multiple Airlines
Mon, Nov 16 - Thu, Dec 3
Multiple Airlines Logo
8:04 pm - 8:32 pmDSM  Des Moines-SFO San Francisco
26h 28m2 stops Las Vegas Harry Reid Intl Los Angeles
Multiple Airlines Logo
10:35 am - 10:26 pmSFO  San Francisco-DSM Des Moines
9h 51m1 stop Las Vegas Harry Reid Intl
$206Multiple Airlines
Mon, Nov 16 - Thu, Dec 3
Frontier Logo
8:35 pm - 12:48 amDSM  Des Moines-SFO San Francisco
6h 13m1 stop Denver Intl
Frontier Logo
10:34 am - 7:50 pmSFO  San Francisco-DSM Des Moines
7h 16m1 stop Denver Intl
$283Frontier
Thu, Dec 3 - Sun, Dec 6
Frontier Logo
8:26 pm - 12:35 amDSM  Des Moines-SFO San Francisco
6h 09m1 stop Denver Intl
Frontier Logo
6:15 am - 7:31 pmSFO  San Francisco-DSM Des Moines
11h 16m1 stop Denver Intl
$300Frontier
Sun, Dec 20 - Thu, Dec 31
American Airlines Logo
7:32 pm - 12:45 amDSM  Des Moines-SFO San Francisco
7h 13m1 stop Dallas/Fort Worth
American Airlines Logo
5:50 am - 2:19 pmSFO  San Francisco-DSM Des Moines
6h 29m1 stop Phoenix Sky Harbor Intl
$319American Airlines
Wed, Dec 2 - Wed, Dec 9
American Airlines Logo
7:32 pm - 12:45 amDSM  Des Moines-SFO San Francisco
7h 13m1 stop Dallas/Fort Worth
American Airlines Logo
8:55 am - 7:01 pmSFO  San Francisco-DSM Des Moines
8h 06m1 stop Chicago O'Hare Intl
$319American Airlines
Wed, Dec 2 - Sat, Dec 5
Delta Logo
7:57 pm - 12:01 amDSM  Des Moines-SFO San Francisco
6h 04m1 stop Minneapolis St Paul
Delta Logo
6:00 am - 2:08 pmSFO  San Francisco-DSM Des Moines
6h 08m1 stop Minneapolis St Paul
$319Delta
Thu, Nov 19 - Tue, Nov 24
Delta Logo
6:45 am - 11:00 amDSM  Des Moines-SFO San Francisco
6h 15m1 stop Minneapolis St Paul
Delta Logo
6:00 am - 4:11 pmSFO  San Francisco-DSM Des Moines
8h 11m1 stop Minneapolis St Paul
$319Delta
Tue, Nov 24 - Tue, Dec 1
Southwest Logo
6:30 pm - 10:15 pmDSM  Des Moines-SFO San Francisco
5h 45m1 stop Denver Intl
Southwest Logo
6:40 am - 5:20 pmSFO  San Francisco-DSM Des Moines
8h 40m2 stops Los Angeles Las Vegas Harry Reid Intl
$324Southwest
Wed, Dec 2 - Sat, Dec 5
Southwest Logo
6:30 pm - 10:15 pmDSM  Des Moines-SFO San Francisco
5h 45m1 stop Denver Intl
Southwest Logo
10:25 am - 8:50 pmSFO  San Francisco-DSM Des Moines
8h 25m2 stops Phoenix Sky Harbor Intl Denver Intl
$324Southwest
Wed, Dec 2 - Wed, Dec 9

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United Airlines flights from Des Moines to San Francisco

Our best United Airlines deals on Des Moines to San Francisco flight tickets
United Airlines
Nov 11
DSM9:55 amDes Moines
7h 40m
1 stop
SFO3:35 pmSan Francisco
Nov 17
SFO8:55 amSan Francisco
5h 12m
1 stop
DSM4:07 pmDes Moines
$598
United Airlines
Nov 11
DSM6:05 amDes Moines
7h 45m
1 stop
SFO11:50 amSan Francisco
Nov 17
SFO4:24 pmSan Francisco
5h 18m
1 stop
DSM11:42 pmDes Moines
$631
United Airlines
Nov 10
DSM1:27 pmDes Moines
5h 57m
1 stop
SFO5:24 pmSan Francisco
Nov 14
SFO9:05 amSan Francisco
5h 02m
1 stop
DSM4:07 pmDes Moines
$757

Frontier flights from Des Moines to San Francisco

Our best Frontier deals on Des Moines to San Francisco flight tickets
Frontier
Dec 3
DSM8:35 pmDes Moines
6h 13m
1 stop
SFO12:48 amSan Francisco
Dec 6
SFO10:34 amSan Francisco
7h 16m
1 stop
DSM7:50 pmDes Moines
$283
Frontier
Dec 20
DSM8:26 pmDes Moines
6h 09m
1 stop
SFO12:35 amSan Francisco
Dec 31
SFO6:15 amSan Francisco
11h 16m
1 stop
DSM7:31 pmDes Moines
$300
Frontier
Dec 13
DSM8:39 pmDes Moines
6h 11m
1 stop
SFO12:50 amSan Francisco
Dec 20
SFO6:15 amSan Francisco
11h 16m
1 stop
DSM7:31 pmDes Moines
$311

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Mon 11/16

8:04 pm-8:19 am

1 stop14h 15m

San Francisco

Thu 12/3

10:35 am-10:26 pm

1 stop9h 51m

$191

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Mon 11/16

8:04 pm-8:32 pm

2 stops26h 28m

San Francisco

Thu 12/3

10:35 am-10:26 pm

1 stop9h 51m

$206

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Thu 12/3

8:35 pm-12:48 am

1 stop6h 13m

San Francisco

Sun 12/6

10:34 am-7:50 pm

1 stop7h 16m

$283

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Sun 12/20

8:26 pm-12:35 am

1 stop6h 09m

San Francisco

Thu 12/31

6:15 am-7:31 pm

1 stop11h 16m

$300

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Wed 12/2

7:32 pm-12:45 am

1 stop7h 13m

San Francisco

Wed 12/9

5:50 am-2:19 pm

1 stop6h 29m

$319

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Wed 12/2

7:32 pm-12:45 am

1 stop7h 13m

San Francisco

Sat 12/5

8:55 am-7:01 pm

1 stop8h 06m

$319
Quickest round-trip

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Thu 11/19

7:57 pm-12:01 am

1 stop6h 04m

San Francisco

Tue 11/24

6:00 am-2:08 pm

1 stop6h 08m

$319

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Tue 11/24

6:45 am-11:00 am

1 stop6h 15m

San Francisco

Tue 12/1

6:00 am-4:11 pm

1 stop8h 11m

$319

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Wed 12/2

6:30 pm-10:15 pm

1 stop5h 45m

San Francisco

Sat 12/5

6:40 am-5:20 pm

2 stops8h 40m

$324

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Wed 12/2

6:30 pm-10:15 pm

1 stop5h 45m

San Francisco

Wed 12/9

10:25 am-8:50 pm

2 stops8h 25m

$324

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Francisco?

Prices are currently low for flights on this route.

Typical prices usually range from $439 to $774.
The lowest price recently found on this route was $191.

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of February, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $386.

How far in advance should I book a flight from Des Moines to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $466 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $367 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of October 2026, prices for Des Moines to San Francisco flights are approximately 79% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Best Price Found

$96

Fastest flight time

5h 29m

Direct flights

None
The best one-way flight to San Francisco from Des Moines in the past 72 hours is $96. The best round-trip flight deal from Des Moines to San Francisco found on momondo in the last 72 hours is $191.
The fastest flight from Des Moines to San Francisco takes 5h 29m
There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.
Search flight deals

Frequently asked questions about flying from Des Moines to San Francisco

  • How far is Des Moines to San Francisco by plane?

    There are 1543.9 mi between Des Moines and San Francisco. Typically, this will take 5h 29m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

    Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

  • How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $120Free CancellationRating
5.5
2,515 reviews
Search Frontier flights
United AirlinesPriceFrom $253Free CancellationRating
7.3
10,454 reviews
Search United Airlines flights
DeltaPriceFrom $302Free CancellationRating
7.8
8,691 reviews
Search Delta flights
American AirlinesPriceFrom $330Free CancellationRating
7.0
12,209 reviews
Search American Airlines flights
SouthwestPriceFrom $371Free CancellationRating
7.9
4,217 reviews
Search Southwest flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Hayward
Santa Clara
Walnut Creek
Bodega Bay
Fremont
Berkeley
Sunnyvale
Half Moon Bay
Vallejo
Roseville
Salinas
Sonoma
Milpitas
Palo Alto
Daly City
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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