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Cheap flights from Des Moines to San Francisco from $119

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:25 pm - 11:17 amDSM  Des Moines-SFO San Francisco
16h 52m1 stop Denver Intl
Frontier Logo
12:20 pm - 7:35 pmSFO  San Francisco-DSM Des Moines
5h 15m1 stop Denver Intl
$209Frontier
Mon, Oct 26 - Fri, Oct 30
Frontier Logo
8:25 pm - 11:17 amDSM  Des Moines-SFO San Francisco
16h 52m1 stop Denver Intl
Frontier Logo
6:02 am - 7:35 pmSFO  San Francisco-DSM Des Moines
11h 33m1 stop Denver Intl
$233Frontier
Mon, Oct 26 - Mon, Nov 2
Multiple Airlines Logo
9:11 pm - 8:19 amDSM  Des Moines-SFO San Francisco
13h 08m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
10:23 pm - 2:38 pmSFO  San Francisco-DSM Des Moines
38h 15m2 stops Las Vegas Harry Reid Intl Phoenix Sky Harbor Intl
$247Multiple Airlines
Mon, Oct 26 - Mon, Nov 2
Multiple Airlines Logo
9:11 pm - 8:32 pmDSM  Des Moines-SFO San Francisco
25h 21m2 stops Las Vegas Harry Reid Intl Los Angeles
Multiple Airlines Logo
11:06 am - 9:10 pmSFO  San Francisco-DSM Des Moines
8h 04m1 stop Las Vegas Harry Reid Intl
$273Multiple Airlines
Mon, Oct 26 - Fri, Oct 30
American Airlines Logo
4:12 pm - 9:07 pmDSM  Des Moines-SFO San Francisco
6h 55m1 stop Dallas/Fort Worth
American Airlines Logo
5:45 am - 1:34 pmSFO  San Francisco-DSM Des Moines
5h 49m1 stop Phoenix Sky Harbor Intl
$337American Airlines
Tue, Oct 20 - Wed, Oct 21
American Airlines Logo
2:30 pm - 7:39 pmDSM  Des Moines-SFO San Francisco
7h 09m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
6:47 am - 3:11 pmSFO  San Francisco-DSM Des Moines
6h 24m1 stop Dallas/Fort Worth
$337American Airlines
Tue, Oct 20 - Wed, Oct 21
United Airlines Logo
5:03 pm - 10:43 pmDSM  Des Moines-SFO San Francisco
7h 40m1 stop Denver Intl
United Airlines Logo
5:00 am - 2:20 pmSFO  San Francisco-DSM Des Moines
7h 20m1 stop Houston George Bush Intcntl
$337United Airlines
Sat, Feb 6 - Tue, Feb 9
United Airlines Logo
8:00 am - 2:42 pmDSM  Des Moines-SFO San Francisco
8h 42m1 stop Chicago O'Hare Intl
United Airlines Logo
4:24 pm - 11:42 pmSFO  San Francisco-DSM Des Moines
5h 18m1 stop Denver Intl
$337United Airlines
Sat, Oct 31 - Sat, Nov 14
Delta Logo
4:53 pm - 12:10 amDSM  Des Moines-SFO San Francisco
9h 17m1 stop Minneapolis St Paul
Delta Logo
10:40 pm - 9:50 amSFO  San Francisco-DSM Des Moines
9h 10m1 stop Detroit Metropolitan Wayne County
$337Delta
Thu, Dec 3 - Mon, Dec 7
Delta Logo
10:15 am - 6:48 pmDSM  Des Moines-SFO San Francisco
10h 33m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:00 am - 4:50 pmSFO  San Francisco-DSM Des Moines
8h 50m1 stop Detroit Metropolitan Wayne County
$337Delta
Sat, Feb 13 - Tue, Feb 16

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Southwest flights from Des Moines to San Francisco

Our best Southwest deals on Des Moines to San Francisco flight tickets
Southwest
Oct 17
DSM5:55 pmDes Moines
5h 20m
1 stop
SFO9:15 pmSan Francisco
Oct 20
SFO11:05 amSan Francisco
7h 35m
2 stops
DSM8:40 pmDes Moines
$356
Southwest
Oct 26
DSM7:10 pmDes Moines
7h 35m
2 stops
SFO12:45 amSan Francisco
Oct 30
SFO8:40 amSan Francisco
7h 50m
2 stops
DSM6:30 pmDes Moines
$361
Southwest
Oct 17
DSM1:20 pmDes Moines
10h 15m
2 stops
SFO9:35 pmSan Francisco
Oct 20
SFO11:05 amSan Francisco
7h 35m
2 stops
DSM8:40 pmDes Moines
$375

Frontier flights from Des Moines to San Francisco

Our best Frontier deals on Des Moines to San Francisco flight tickets
Frontier
Oct 26
DSM8:25 pmDes Moines
16h 52m
1 stop
SFO11:17 amSan Francisco
Oct 30
SFO12:20 pmSan Francisco
5h 15m
1 stop
DSM7:35 pmDes Moines
$209
Frontier
Oct 23
DSM8:25 pmDes Moines
5h 50m
1 stop
SFO12:15 amSan Francisco
Oct 26
SFO6:00 amSan Francisco
11h 30m
1 stop
DSM7:30 pmDes Moines
$234
Frontier
Oct 19
DSM8:25 pmDes Moines
16h 40m
1 stop
SFO11:05 amSan Francisco
Nov 2
SFO6:02 amSan Francisco
11h 33m
1 stop
DSM7:35 pmDes Moines
$238

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Mon 10/26

8:25 pm-11:17 am

1 stop16h 52m

San Francisco

Fri 10/30

12:20 pm-7:35 pm

1 stop5h 15m

$209

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Mon 10/26

8:25 pm-11:17 am

1 stop16h 52m

San Francisco

Mon 11/2

6:02 am-7:35 pm

1 stop11h 33m

$233

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Mon 10/26

9:11 pm-8:19 am

1 stop13h 08m

San Francisco

Mon 11/2

10:23 pm-2:38 pm

2 stops38h 15m

$247

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Mon 10/26

9:11 pm-8:32 pm

2 stops25h 21m

San Francisco

Fri 10/30

11:06 am-9:10 pm

1 stop8h 04m

$273
Quickest round-trip

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Tue 10/20

4:12 pm-9:07 pm

1 stop6h 55m

San Francisco

Wed 10/21

5:45 am-1:34 pm

1 stop5h 49m

$337

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Tue 10/20

2:30 pm-7:39 pm

1 stop7h 09m

San Francisco

Wed 10/21

6:47 am-3:11 pm

1 stop6h 24m

$337

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Sat 2/6

5:03 pm-10:43 pm

1 stop7h 40m

San Francisco

Tue 2/9

5:00 am-2:20 pm

1 stop7h 20m

$337

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Sat 10/31

8:00 am-2:42 pm

1 stop8h 42m

San Francisco

Sat 11/14

4:24 pm-11:42 pm

1 stop5h 18m

$337

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Thu 12/3

4:53 pm-12:10 am

1 stop9h 17m

San Francisco

Mon 12/7

10:40 pm-9:50 am

1 stop9h 10m

$337

Des MoinesSan Francisco

DSM Des Moines - SFO San Francisco

DSMSFO

Des Moines

Sat 2/13

10:15 am-6:48 pm

1 stop10h 33m

San Francisco

Tue 2/16

6:00 am-4:50 pm

1 stop8h 50m

$337

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Francisco?

Prices are currently low for flights on this route.

Typical prices usually range from $371 to $559.
The lowest price recently found on this route was $209.

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of February, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $386.

How far in advance should I book a flight from Des Moines to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $462 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $367 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of September 2026, prices for Des Moines to San Francisco flights are approximately 47% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Best Price Found

$119

Fastest flight time

5h 42m

Direct flights

None
The best one-way flight to San Francisco from Des Moines in the past 72 hours is $119. The best round-trip flight deal from Des Moines to San Francisco found on momondo in the last 72 hours is $209.
The fastest flight from Des Moines to San Francisco takes 5h 42m
There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.
Search flight deals

Frequently asked questions about flying from Des Moines to San Francisco

  • How far is Des Moines to San Francisco by plane?

    There are 1543.9 mi between Des Moines and San Francisco. Typically, this will take 5h 42m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

    Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

  • How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $120Free CancellationRating
5.6
2,567 reviews
Search Frontier flights
United AirlinesPriceFrom $253Free CancellationRating
7.4
10,261 reviews
Search United Airlines flights
DeltaPriceFrom $286Free CancellationRating
7.8
8,608 reviews
Search Delta flights
American AirlinesPriceFrom $330Free CancellationRating
7.0
12,097 reviews
Search American Airlines flights
SouthwestPriceFrom $371Free CancellationRating
8.0
4,204 reviews
Search Southwest flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Hayward
Berkeley
Bodega Bay
Fremont
Walnut Creek
Santa Clara
Sunnyvale
Vallejo
Half Moon Bay
Roseville
Salinas
Sonoma
Milpitas
Daly City
Pacific Grove
Palo Alto

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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