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Cheap flights from Des Moines to San Francisco from $81

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 2/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:17 pm - 8:03 am
DSM
-
SFO
14h 46m1 stop
Frontier Logo
6:15 am - 6:19 pm
SFO
-
DSM
10h 04m1 stop
$153Frontier
Fri, Feb 13 - Fri, Feb 20
Frontier Logo
7:17 pm - 8:03 am
DSM
-
SFO
14h 46m1 stop
Frontier Logo
8:48 am - 6:19 pm
SFO
-
DSM
7h 31m1 stop
$155Frontier
Fri, Feb 13 - Fri, Feb 20
Frontier Logo
7:17 pm - 8:03 am
DSM
-
SFO
14h 46m1 stop
Frontier Logo
8:48 am - 6:19 pm
SFO
-
DSM
7h 31m1 stop
$156Frontier
Fri, Feb 13 - Fri, Feb 20
Frontier Logo
7:32 pm - 8:03 am
DSM
-
SFO
14h 31m1 stop
Frontier Logo
6:15 am - 6:47 pm
SFO
-
DSM
10h 32m1 stop
$169Frontier
Thu, Feb 12 - Thu, Feb 19
Frontier Logo
7:32 pm - 8:03 am
DSM
-
SFO
14h 31m1 stop
Frontier Logo
8:48 am - 6:47 pm
SFO
-
DSM
7h 59m1 stop
$171Frontier
Thu, Feb 12 - Thu, Feb 19
Frontier Logo
7:32 pm - 8:03 am
DSM
-
SFO
14h 31m1 stop
Frontier Logo
8:48 am - 6:47 pm
SFO
-
DSM
7h 59m1 stop
$172Frontier
Thu, Feb 12 - Thu, Feb 19
Frontier Logo
7:32 pm - 12:28 am
DSM
-
SFO
6h 56m1 stop
Frontier Logo
6:15 am - 6:47 pm
SFO
-
DSM
10h 32m1 stop
$182Frontier
Thu, Feb 12 - Thu, Feb 19
Frontier Logo
7:32 pm - 12:28 am
DSM
-
SFO
6h 56m1 stop
Frontier Logo
6:15 am - 6:47 pm
SFO
-
DSM
10h 32m1 stop
$183Frontier
Thu, Feb 12 - Thu, Feb 19
Frontier Logo
7:17 pm - 5:58 pm
DSM
-
SFO
24h 41m2 stops
Frontier Logo
8:48 am - 6:19 pm
SFO
-
DSM
7h 31m1 stop
$191Frontier
Fri, Feb 13 - Fri, Feb 20
Frontier Logo
7:17 pm - 5:58 pm
DSM
-
SFO
24h 41m2 stops
Frontier Logo
6:15 am - 6:19 pm
SFO
-
DSM
10h 04m1 stop
$192Frontier
Fri, Feb 13 - Fri, Feb 20

Frontier flights from Des Moines to San Francisco

Our best Frontier deals on Des Moines to San Francisco flight tickets
Frontier
Feb 13
DSM7:17 pmDes Moines
14h 46m
1 stop
SFO8:03 amSan Francisco
Feb 20
SFO6:15 amSan Francisco
10h 04m
1 stop
DSM6:19 pmDes Moines
$153
Find similar
Frontier
Feb 13
DSM7:17 pmDes Moines
14h 46m
1 stop
SFO8:03 amSan Francisco
Feb 20
SFO8:48 amSan Francisco
7h 31m
1 stop
DSM6:19 pmDes Moines
$155
Find similar
Frontier
Feb 13
DSM7:17 pmDes Moines
14h 46m
1 stop
SFO8:03 amSan Francisco
Feb 20
SFO8:48 amSan Francisco
7h 31m
1 stop
DSM6:19 pmDes Moines
$156
Find similar

American Airlines flights from Des Moines to San Francisco

Our best American Airlines deals on Des Moines to San Francisco flight tickets
American Airlines
Feb 14
DSM10:04 amDes Moines
8h 39m
1 stop
SFO4:43 pmSan Francisco
Feb 20
SFO12:26 amSan Francisco
10h 51m
1 stop
DSM1:17 pmDes Moines
$342
Find similar
American Airlines
Feb 14
DSM6:08 pmDes Moines
7h 02m
1 stop
SFO11:10 pmSan Francisco
Feb 21
SFO6:00 amSan Francisco
7h 28m
1 stop
DSM3:28 pmDes Moines
$343
Find similar
American Airlines
Feb 14
DSM3:58 pmDes Moines
8h 13m
1 stop
SFO10:11 pmSan Francisco
Feb 21
SFO6:00 amSan Francisco
7h 28m
1 stop
DSM3:28 pmDes Moines
$345
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 1, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 2/13

7:17 pm-8:03 am

1 stop14h 46m

San Francisco

Fri 2/20

6:15 am-6:19 pm

1 stop10h 04m

$153

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 2/13

7:17 pm-8:03 am

1 stop14h 46m

San Francisco

Fri 2/20

8:48 am-6:19 pm

1 stop7h 31m

$155

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 2/13

7:17 pm-8:03 am

1 stop14h 46m

San Francisco

Fri 2/20

8:48 am-6:19 pm

1 stop7h 31m

$156

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 2/12

7:32 pm-8:03 am

1 stop14h 31m

San Francisco

Thu 2/19

6:15 am-6:47 pm

1 stop10h 32m

$169

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 2/12

7:32 pm-8:03 am

1 stop14h 31m

San Francisco

Thu 2/19

8:48 am-6:47 pm

1 stop7h 59m

$171

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 2/12

7:32 pm-8:03 am

1 stop14h 31m

San Francisco

Thu 2/19

8:48 am-6:47 pm

1 stop7h 59m

$172

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 2/12

7:32 pm-12:28 am

1 stop6h 56m

San Francisco

Thu 2/19

6:15 am-6:47 pm

1 stop10h 32m

$182

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 2/12

7:32 pm-12:28 am

1 stop6h 56m

San Francisco

Thu 2/19

6:15 am-6:47 pm

1 stop10h 32m

$183

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 2/13

7:17 pm-5:58 pm

2 stops24h 41m

San Francisco

Fri 2/20

8:48 am-6:19 pm

1 stop7h 31m

$191

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 2/13

7:17 pm-5:58 pm

2 stops24h 41m

San Francisco

Fri 2/20

6:15 am-6:19 pm

1 stop10h 04m

$192

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of September, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $374.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $436 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $347 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of January 2026, prices for Des Moines to San Francisco flights are approximately 19% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Fastest flight time

5h 29m

Direct flights

None
The fastest flight from Des Moines to San Francisco takes 5h 29m
There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.
Search flight deals

  • How far is Des Moines to San Francisco by plane?

    There are 1544.3 mi between Des Moines and San Francisco. Typically, this will take 5h 29m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

    Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

  • How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $158Free CancellationRating
5.7
3,069 reviews
Search Frontier flights
DeltaPriceFrom $265Free CancellationRating
7.9
8,021 reviews
Search Delta flights
American AirlinesPriceFrom $334Free CancellationRating
7.2
11,074 reviews
Search American Airlines flights
SouthwestPriceFrom $336Free CancellationRating
8.0
4,254 reviews
Search Southwest flights
United AirlinesPriceFrom $356Free CancellationRating
7.4
9,132 reviews
Search United Airlines flights

  • United Airlines Flights From Des Moines to San Francisco

    The lowest priced United Airlines flight from Des Moines to San Francisco from the last 72 hours was $356. Generally, United Airlines has 1 flight on this route every week with an average price of $487. United Airlines is rated 7.4/10 by our users.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Santa Clara
Berkeley
Walnut Creek
Fremont
Daly City
Half Moon Bay
Vallejo
Livermore
Salinas
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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