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Cheap flights from Des Moines to San Francisco from $110

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 9/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:31 pm - 8:14 am
DSM
-
SFO
12h 43m
1 stop
Multiple Airlines Logo
3:15 pm - 1:52 pm
SFO
-
DSM
20h 37m
1 stop
$190Multiple Airlines
Mon, Sep 21 - Tue, Sep 29
Multiple Airlines Logo
2:42 pm - 11:51 pm
DSM
-
SFO
11h 09m
1 stop
Multiple Airlines Logo
4:00 pm - 1:52 pm
SFO
-
DSM
19h 52m
1 stop
$190Multiple Airlines
Wed, Oct 21 - Tue, Oct 27
Frontier Logo
2:19 pm - 6:45 pm
DSM
-
SFO
6h 26m
1 stop
Frontier Logo
6:00 am - 1:34 pm
SFO
-
DSM
5h 34m
1 stop
$204Frontier
Mon, Aug 24 - Mon, Aug 31
Frontier Logo
11:29 am - 12:14 am
DSM
-
SFO
14h 45m
1 stop
Frontier Logo
11:42 am - 7:33 pm
SFO
-
DSM
5h 51m
1 stop
$212Frontier
Thu, Sep 10 - Mon, Sep 14
American Airlines Logo
9:51 am - 3:01 pm
DSM
-
SFO
7h 10m
1 stop
American Airlines Logo
2:58 pm - 12:04 am
SFO
-
DSM
7h 06m
1 stop
$300American Airlines
Sat, Sep 12 - Sat, Sep 19
American Airlines Logo
6:57 pm - 11:51 pm
DSM
-
SFO
6h 54m
1 stop
American Airlines Logo
10:22 am - 6:26 pm
SFO
-
DSM
6h 04m
1 stop
$300American Airlines
Thu, Sep 10 - Thu, Sep 17
Southwest Logo
5:30 am - 1:10 pm
DSM
-
SFO
9h 40m
1 stop
Southwest Logo
6:40 am - 2:10 pm
SFO
-
DSM
5h 30m
1 stop
$301Southwest
Sat, Sep 12 - Sat, Sep 19
Southwest Logo
6:25 pm - 10:00 pm
DSM
-
SFO
5h 35m
1 stop
Southwest Logo
1:25 pm - 8:40 pm
SFO
-
DSM
5h 15m
1 stop
$301Southwest
Wed, Jan 6 - Tue, Jan 12
Delta Logo
2:46 pm - 8:32 pm
DSM
-
SFO
7h 46m
1 stop
Delta Logo
6:35 am - 4:48 pm
SFO
-
DSM
8h 13m
1 stop
$301Delta
Wed, Sep 23 - Tue, Sep 29
Delta Logo
2:46 pm - 8:32 pm
DSM
-
SFO
7h 46m
1 stop
Delta Logo
12:05 am - 10:17 am
SFO
-
DSM
8h 12m
1 stop
$301Delta
Wed, Sep 23 - Fri, Sep 25

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Frontier flights from Des Moines to San Francisco

Our best Frontier deals on Des Moines to San Francisco flight tickets
Frontier
Aug 24
DSM2:19 pmDes Moines
6h 26m
1 stop
SFO6:45 pmSan Francisco
Aug 31
SFO6:00 amSan Francisco
5h 34m
1 stop
DSM1:34 pmDes Moines
$204
Frontier
Sep 10
DSM11:29 amDes Moines
14h 45m
1 stop
SFO12:14 amSan Francisco
Sep 14
SFO11:42 amSan Francisco
5h 51m
1 stop
DSM7:33 pmDes Moines
$212
Frontier
Sep 14
DSM8:30 pmDes Moines
16h 17m
1 stop
SFO10:47 amSan Francisco
Sep 21
SFO6:04 amSan Francisco
11h 29m
1 stop
DSM7:33 pmDes Moines
$226

American Airlines flights from Des Moines to San Francisco

Our best American Airlines deals on Des Moines to San Francisco flight tickets
American Airlines
Aug 15
DSM2:39 pmDes Moines
6h 26m
1 stop
SFO7:05 pmSan Francisco
Aug 18
SFO5:33 amSan Francisco
5h 56m
1 stop
DSM1:29 pmDes Moines
$449
American Airlines
Aug 15
DSM9:32 amDes Moines
8h 30m
2 stops
SFO4:02 pmSan Francisco
Aug 18
SFO5:33 amSan Francisco
5h 56m
1 stop
DSM1:29 pmDes Moines
$454
American Airlines
Aug 13
DSM4:13 pmDes Moines
8h 57m
1 stop
SFO11:10 pmSan Francisco
Aug 16
SFO5:33 amSan Francisco
5h 56m
1 stop
DSM1:29 pmDes Moines
$597

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 1, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 9/21

9:31 pm-8:14 am

1 stop12h 43m

San Francisco

Tue 9/29

3:15 pm-1:52 pm

1 stop20h 37m

$190

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 10/21

2:42 pm-11:51 pm

1 stop11h 09m

San Francisco

Tue 10/27

4:00 pm-1:52 pm

1 stop19h 52m

$190

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 8/24

2:19 pm-6:45 pm

1 stop6h 26m

San Francisco

Mon 8/31

6:00 am-1:34 pm

1 stop5h 34m

$204

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 9/10

11:29 am-12:14 am

1 stop14h 45m

San Francisco

Mon 9/14

11:42 am-7:33 pm

1 stop5h 51m

$212

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sat 9/12

9:51 am-3:01 pm

1 stop7h 10m

San Francisco

Sat 9/19

2:58 pm-12:04 am

1 stop7h 06m

$300

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 9/10

6:57 pm-11:51 pm

1 stop6h 54m

San Francisco

Thu 9/17

10:22 am-6:26 pm

1 stop6h 04m

$300

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Sat 9/12

5:30 am-1:10 pm

1 stop9h 40m

San Francisco

Sat 9/19

6:40 am-2:10 pm

1 stop5h 30m

$301
Quickest round-trip

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 1/6

6:25 pm-10:00 pm

1 stop5h 35m

San Francisco

Tue 1/12

1:25 pm-8:40 pm

1 stop5h 15m

$301

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 9/23

2:46 pm-8:32 pm

1 stop7h 46m

San Francisco

Tue 9/29

6:35 am-4:48 pm

1 stop8h 13m

$301

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 9/23

2:46 pm-8:32 pm

1 stop7h 46m

San Francisco

Fri 9/25

12:05 am-10:17 am

1 stop8h 12m

$301

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Francisco?

Prices are currently low for flights on this route.

Typical prices usually range from $365 to $553.
The lowest price recently found on this route was $190.

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of September, then flying in February is also cheap. Prices for this month can be found on momondo for an average of $367.

How far in advance should I book a flight from Des Moines to San Francisco?

You are more likely to see cheaper flights to San Francisco from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $454 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Des Moines for as low as $354 on momondo.

How have Des Moines to San Francisco flight prices changed over time?

As of August 2026, prices for Des Moines to San Francisco flights are approximately 37% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Francisco (DSM to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Francisco

Fastest flight time

5h 35m

Direct flights

None
The fastest flight from Des Moines to San Francisco takes 5h 35m
There are no direct flights from Des Moines to San Francisco. There are no popular flight routes from Des Moines to San Francisco.
Search flight deals

Frequently asked questions about flying from Des Moines to San Francisco

  • How far is Des Moines to San Francisco by plane?

    There are 1543.9 mi between Des Moines and San Francisco. Typically, this will take 5h 35m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to San Francisco Airport?

    Prices for flights from Des Moines Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Francisco Airport?

  • How old do you have to be to fly from Des Moines Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents you'll need for your trip to San Francisco Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Francisco Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Francisco?

Best airlines flying from Des Moines to San Francisco

Compare and see reviews for airlines that fly from Des Moines to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $120Free CancellationRating
5.6
2,740 reviews
Search Frontier flights
United AirlinesPriceFrom $253Free CancellationRating
7.4
10,062 reviews
Search United Airlines flights
DeltaPriceFrom $274Free CancellationRating
7.8
8,497 reviews
Search Delta flights
American AirlinesPriceFrom $346Free CancellationRating
7.1
11,845 reviews
Search American Airlines flights
SouthwestPriceFrom $349Free CancellationRating
8.0
4,229 reviews
Search Southwest flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Fremont
Berkeley
Hayward
Walnut Creek
Bodega Bay
Sonoma
Roseville
Santa Clara
Vallejo
Salinas
Sunnyvale
Burlingame
Milpitas
Daly City
Palo Alto
Big Sur

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Francisco?

Finding the right flight to San Francisco from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Francisco quick and easy, saving you time and money.

Can I find flights from Des Moines to San Francisco with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Francisco flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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