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Cheap flights from Des Moines to Jacksonville from $46

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Jacksonville departing on 9/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Jacksonville

Cheap round-trip flights

Allegiant Air Logo
7:30 am - 11:13 amDSM-JAX
2h 43mnonstop
Allegiant Air Logo
12:03 pm - 2:01 pmJAX-DSM
2h 58mnonstop
$93Allegiant Air
Find Deal
Thu, Oct 30 - Sun, Nov 2
Allegiant Air Logo
6:30 am - 10:13 amDSM-JAX
2h 43mnonstop
Allegiant Air Logo
11:03 am - 1:01 pmJAX-DSM
2h 58mnonstop
$95Allegiant Air
Find Deal
Thu, Oct 16 - Sun, Oct 19
Logo
2:32 pm - 6:09 pmDSM-JAX
26h 37m2 stops
Logo
12:03 pm - 2:01 pmJAX-DSM
2h 58mnonstop
$195
Find Deal
Thu, Oct 30 - Sun, Nov 2
Logo
2:32 pm - 6:09 pmDSM-JAX
26h 37m2 stops
Logo
12:03 pm - 2:01 pmJAX-DSM
2h 58mnonstop
$200
Find Deal
Thu, Nov 13 - Sun, Nov 16
Southwest Logo
6:20 am - 11:10 amDSM-JAX
3h 50m1 stop
Southwest Logo
6:50 pm - 9:50 pmJAX-DSM
4h 00m1 stop
$211Southwest
Find Deal
Wed, Oct 8 - Wed, Oct 15
American Airlines Logo
6:22 pm - 12:33 amDSM-JAX
5h 11m1 stop
American Airlines Logo
7:22 am - 11:25 amJAX-DSM
5h 03m1 stop
$226American Airlines
Find Deal
Sat, Oct 25 - Sat, Nov 1
Delta Logo
2:15 pm - 8:40 pmDSM-JAX
5h 25m1 stop
Delta Logo
7:00 am - 1:30 pmJAX-DSM
7h 30m1 stop
$227Delta
Find Deal
Sat, Dec 6 - Sat, Dec 13
Delta Logo
2:15 pm - 8:40 pmDSM-JAX
5h 25m1 stop
Delta Logo
7:10 am - 1:30 pmJAX-DSM
7h 20m1 stop
$228Delta
Find Deal
Sat, Dec 6 - Wed, Dec 17
American Airlines Logo
6:00 am - 2:31 pmDSM-JAX
7h 31m2 stops
American Airlines Logo
8:32 am - 3:03 pmJAX-DSM
7h 31m1 stop
$232American Airlines
Find Deal
Sat, Oct 25 - Sat, Nov 1
Southwest Logo
6:15 pm - 11:10 pmDSM-JAX
3h 55m1 stop
Southwest Logo
6:50 pm - 9:50 pmJAX-DSM
4h 00m1 stop
$262Southwest
Find Deal
Mon, Oct 20 - Tue, Oct 28

Delta flights from Des Moines to Jacksonville

Our best Delta deals on Des Moines to Jacksonville flight tickets
Delta
Dec 6
DSM2:15 pmDes Moines
5h 25m
1 stop
JAX8:40 pmJacksonville
Dec 13
JAX7:00 amJacksonville
7h 30m
1 stop
DSM1:30 pmDes Moines
$227
Find similar
Delta
Dec 6
DSM2:15 pmDes Moines
5h 25m
1 stop
JAX8:40 pmJacksonville
Dec 17
JAX7:10 amJacksonville
7h 20m
1 stop
DSM1:30 pmDes Moines
$228
Find similar
Delta
Dec 9
DSM5:34 amDes Moines
4h 10m
1 stop
JAX10:44 amJacksonville
Dec 17
JAX9:46 amJacksonville
4h 44m
1 stop
DSM1:30 pmDes Moines
$229
Find similar

Southwest flights from Des Moines to Jacksonville

Our best Southwest deals on Des Moines to Jacksonville flight tickets
Southwest
Oct 8
DSM6:20 amDes Moines
3h 50m
1 stop
JAX11:10 amJacksonville
Oct 15
JAX6:50 pmJacksonville
4h 00m
1 stop
DSM9:50 pmDes Moines
$211
Find similar
Southwest
Oct 20
DSM6:15 pmDes Moines
3h 55m
1 stop
JAX11:10 pmJacksonville
Oct 28
JAX6:50 pmJacksonville
4h 00m
1 stop
DSM9:50 pmDes Moines
$262
Find similar
Southwest
Oct 20
DSM6:15 pmDes Moines
3h 55m
1 stop
JAX11:10 pmJacksonville
Oct 28
JAX11:55 amJacksonville
10h 55m
2 stops
DSM9:50 pmDes Moines
$268
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Jacksonville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Des Moines to Jacksonville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Thu 10/30

7:30 am-11:13 am

Nonstop2h 43m

Jacksonville

Sun 11/2

12:03 pm-2:01 pm

Nonstop2h 58m

$93

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Thu 10/16

6:30 am-10:13 am

Nonstop2h 43m

Jacksonville

Sun 10/19

11:03 am-1:01 pm

Nonstop2h 58m

$95

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Thu 10/30

2:32 pm-6:09 pm

2 stops26h 37m

Jacksonville

Sun 11/2

12:03 pm-2:01 pm

Nonstop2h 58m

$195

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Thu 11/13

2:32 pm-6:09 pm

2 stops26h 37m

Jacksonville

Sun 11/16

12:03 pm-2:01 pm

Nonstop2h 58m

$200

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Wed 10/8

6:20 am-11:10 am

1 stop3h 50m

Jacksonville

Wed 10/15

6:50 pm-9:50 pm

1 stop4h 00m

$211

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Sat 10/25

6:22 pm-12:33 am

1 stop5h 11m

Jacksonville

Sat 11/1

7:22 am-11:25 am

1 stop5h 03m

$226

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Sat 12/6

2:15 pm-8:40 pm

1 stop5h 25m

Jacksonville

Sat 12/13

7:00 am-1:30 pm

1 stop7h 30m

$227

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Sat 12/6

2:15 pm-8:40 pm

1 stop5h 25m

Jacksonville

Wed 12/17

7:10 am-1:30 pm

1 stop7h 20m

$228

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Sat 10/25

6:00 am-2:31 pm

2 stops7h 31m

Jacksonville

Sat 11/1

8:32 am-3:03 pm

1 stop7h 31m

$232

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Mon 10/20

6:15 pm-11:10 pm

1 stop3h 55m

Jacksonville

Tue 10/28

6:50 pm-9:50 pm

1 stop4h 00m

$262

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Jacksonville from

How to get the cheapest flight ticket from Des Moines to Jacksonville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Jacksonville?

If you are unable to visit Jacksonville during the month of August, then departing from Des Moines during the month July is also very affordable. Most momondo users find prices during this month for around $133.

What is the cheapest day to depart on your flight to Jacksonville?

According to our data, Sunday is the cheapest day to fly to Jacksonville from Des Moines. The lowest ticket price found for a Sunday departure recently was $90. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Monday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $513.

What is the cheapest time of day to depart on your flight to Jacksonville?

Flying to Jacksonville from Des Moines in the morning is the least expensive time of day to depart. momondo users have found prices as low as $90 when looking at flights departing in the morning. Flights to Jacksonville are more costly in the afternoon, with an average ticket price of $397. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Des Moines to Jacksonville flight route?

Fly from Des Moines to Jacksonville for the best Des Moines - Jacksonville flight prices

How far in advance should I book a flight to Jacksonville?

You are more likely to see cheaper flights to Jacksonville from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Jacksonville for around $319 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Jacksonville from Des Moines for as low as $220 on momondo.

What cabin class options are available on Des Moines to Jacksonville flights?

There is only 1 cabin class available to choose from on Des Moines to Jacksonville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Des Moines to Jacksonville flight prices changed over time?

As of September 2025, prices for Des Moines to Jacksonville flights are approximately 10% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to Jacksonville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Jacksonville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Jacksonville (DSM to JAX) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Jacksonville

Best Price Found

$96

Fastest flight time

2h 43m

Direct flights

Mon and Fri

Airports in Jacksonville

1 airport
The best one-way flight to Jacksonville from Des Moines in the past 72 hours is $96. The best round-trip flight deal from Des Moines to Jacksonville found on momondo in the last 72 hours is $90.
The fastest flight from Des Moines to Jacksonville takes 2h 43m
Direct flights go from Des Moines to Jacksonville on Monday and Friday. The only airline offering direct flights is Allegiant Air.
There is 1 airport near Jacksonville: Jacksonville (JAX)
Search flight deals

  • How far is Des Moines to Jacksonville by plane?

    There are 1023.3 mi between Des Moines and Jacksonville. In terms of flight time, this usually takes a little over 2h 43m.

  • When did momondo last update prices for flights from Des Moines Airport to Jacksonville Airport?

    Prices for flights from Des Moines Airport to Jacksonville Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Jacksonville Airport?

  • How old do you have to be to fly from Des Moines Airport to Jacksonville Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Jacksonville Airport.

  • What documentation or ID do you need to fly to Jacksonville Airport?

    The travel and health documents required for your trip to Jacksonville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Jacksonville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Des Moines to Jacksonville?

  • What is the most popular airline from Des Moines to Jacksonville?

Best airlines flying from Des Moines to Jacksonville

Compare and see reviews for airlines that fly from Des Moines to Jacksonville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $81Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
DeltaPriceFrom $231Free CancellationRating
7.9
7,960 reviews
Search Delta flights
American AirlinesPriceFrom $301Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $308Free CancellationRating
8.0
4,248 reviews
Search Southwest flights

  • Allegiant Air Flights From Des Moines to Jacksonville

    Allegiant Air is one of the most popular airlines flying from Des Moines to Jacksonville, operating 2 flights/week on average for this route. A good Allegiant Air flight deal for Des Moines to Jacksonville starts from $81 round-trip, up to an average price of $91. Our users have rated Allegiant Air at 7.2/10.

Traveling to a place near Jacksonville?

Book flights to Jacksonville if you plan to visit one of these locations
Fernandina Beach
Jacksonville Beach
Orange Park
Ponte Vedra Beach
Kingsland
Waycross
Atlantic Beach
Neptune Beach
St Johns
Yulee
Cumberland Island

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Jacksonville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Jacksonville. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Jacksonville with flexible booking policies on momondo?

All flight searches from Des Moines to Jacksonville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Jacksonville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Jacksonville.

I’m not ready to book a flight from Des Moines to Jacksonville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Jacksonville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Jacksonville and let you know when they change.

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