Cheap flights from Des Moines to Jacksonville from $41

If you are unable to visit Jacksonville during the month of October, then departing from Des Moines during the month August is also very affordable. Most momondo users find prices during this month for around $90.

According to our data, Thursday is the cheapest day to fly to Jacksonville from Des Moines. The lowest ticket price found for a Thursday departure recently was $99. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Sunday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $111.

Flying to Jacksonville from Des Moines in the morning is the least expensive time of day to depart. momondo users have found prices as low as $94 when looking at flights departing in the morning. Flights to Jacksonville are more costly in the afternoon, with an average ticket price of $150. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Des Moines to Jacksonville for the best Des Moines - Jacksonville flight prices

You are more likely to see cheaper flights to Jacksonville from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Jacksonville for around $257 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Jacksonville from Des Moines for as low as $107 on momondo.

There is only 1 cabin class available to choose from on Des Moines to Jacksonville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Des Moines to Jacksonville.

As of June 2026, prices for Des Moines to Jacksonville flights are approximately 60% cheaper when compared to flights at the same time last year.

Delta, Southwest, and United Airlines are the most popular carriers operating from Des Moines to Jacksonville

Allegiant Air, Delta and American Airlines are the top three most popular airlines that fly to Jacksonville from Des Moines according to our data. Allegiant Air is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Jacksonville. Keep in mind that there are 4 different airlines that fly to Jacksonville on a routine basis, so you have a few additional options to choose from.