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Cheap flights from Des Moines to Fort Myers from $109

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Fort Myers departing on 8/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Fort Myers

Cheap round-trip flights

Frontier Logo
2:25 pm - 8:58 amDSM-RSW
17h 33m2 stops
Frontier Logo
10:01 pm - 1:40 pmRSW-DSM
16h 39m2 stops
$237Frontier
Find Deal
Thu, Sep 4 - Sun, Sep 7
American Airlines Logo
6:00 am - 1:48 pmDSM-RSW
6h 48m1 stop
American Airlines Logo
11:08 am - 5:02 pmRSW-DSM
6h 54m1 stop
$251American Airlines
Find Deal
Wed, Oct 15 - Wed, Oct 22
American Airlines Logo
6:00 am - 1:48 pmDSM-RSW
6h 48m1 stop
American Airlines Logo
4:44 pm - 11:23 pmRSW-DSM
7h 39m2 stops
$256American Airlines
Find Deal
Wed, Oct 15 - Wed, Oct 22
Delta Logo
6:30 pm - 12:29 amDSM-RSW
4h 59m1 stop
Delta Logo
6:15 pm - 10:37 pmRSW-DSM
5h 22m1 stop
$264Delta
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Wed, Sep 24 - Mon, Sep 29
United Airlines Logo
11:35 am - 8:18 pmDSM-RSW
7h 43m1 stop
United Airlines Logo
9:15 am - 2:20 pmRSW-DSM
6h 05m1 stop
$277United Airlines
Find Deal
Mon, Sep 15 - Thu, Sep 18
Allegiant Air Logo
1:56 pm - 6:00 pmDSM-RSW
3h 04mnonstop
Allegiant Air Logo
6:50 pm - 9:09 pmRSW-DSM
3h 19mnonstop
$291Allegiant Air
Find Deal
Fri, Nov 21 - Mon, Nov 24
Delta Logo
5:15 pm - 12:37 amDSM-RSW
6h 22m1 stop
Delta Logo
5:40 pm - 10:28 pmRSW-DSM
5h 48m1 stop
$295Delta
Find Deal
Thu, Jan 22 - Sat, Jan 31
Southwest Logo
6:15 pm - 11:35 pmDSM-RSW
4h 20m1 stop
Southwest Logo
7:45 pm - 11:35 pmRSW-DSM
4h 50m1 stop
$317Southwest
Find Deal
Thu, Nov 6 - Sun, Nov 9
Southwest Logo
8:00 am - 6:25 pmDSM-RSW
9h 25m2 stops
Southwest Logo
7:50 am - 11:25 amRSW-DSM
4h 35m1 stop
$322Southwest
Find Deal
Fri, Nov 14 - Mon, Nov 17
United Airlines Logo
8:00 am - 2:46 pmDSM-RSW
5h 46m1 stop
United Airlines Logo
2:29 pm - 9:40 pmRSW-DSM
8h 11m1 stop
$341United Airlines
Find Deal
Sat, Dec 13 - Mon, Dec 29

Delta flights from Des Moines to Fort Myers

Our best Delta deals on Des Moines to Fort Myers flight tickets
Delta
Sep 24
DSM6:30 pmDes Moines
4h 59m
1 stop
RSW12:29 amFort Myers SW Florida Intl
Sep 29
RSW6:15 pmFort Myers SW Florida Intl
5h 22m
1 stop
DSM10:37 pmDes Moines
$264
Find similar
Delta
Jan 22
DSM5:15 pmDes Moines
6h 22m
1 stop
RSW12:37 amFort Myers SW Florida Intl
Jan 31
RSW5:40 pmFort Myers SW Florida Intl
5h 48m
1 stop
DSM10:28 pmDes Moines
$295
Find similar
Delta
Sep 25
DSM6:30 pmDes Moines
5h 05m
1 stop
RSW12:35 amFort Myers SW Florida Intl
Sep 28
RSW7:00 amFort Myers SW Florida Intl
4h 44m
1 stop
DSM10:44 amDes Moines
$311
Find similar

American Airlines flights from Des Moines to Fort Myers

Our best American Airlines deals on Des Moines to Fort Myers flight tickets
American Airlines
Oct 15
DSM6:00 amDes Moines
6h 48m
1 stop
RSW1:48 pmFort Myers SW Florida Intl
Oct 22
RSW11:08 amFort Myers SW Florida Intl
6h 54m
1 stop
DSM5:02 pmDes Moines
$251
Find similar
American Airlines
Oct 15
DSM6:00 amDes Moines
6h 48m
1 stop
RSW1:48 pmFort Myers SW Florida Intl
Oct 22
RSW4:44 pmFort Myers SW Florida Intl
7h 39m
2 stops
DSM11:23 pmDes Moines
$256
Find similar
American Airlines
Oct 29
DSM6:00 amDes Moines
7h 11m
1 stop
RSW2:11 pmFort Myers SW Florida Intl
Nov 4
RSW5:00 pmFort Myers SW Florida Intl
6h 08m
1 stop
DSM10:08 pmDes Moines
$257
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 16, 2025.
Use the filters below to find and compare flights from Des Moines to Fort Myers that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

Thu 9/4

2:25 pm-8:58 am

2 stops17h 33m

Fort Myers SW Florida Intl

Sun 9/7

10:01 pm-1:40 pm

2 stops16h 39m

$237

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

Wed 10/15

6:00 am-1:48 pm

1 stop6h 48m

Fort Myers SW Florida Intl

Wed 10/22

11:08 am-5:02 pm

1 stop6h 54m

$251

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

Wed 10/15

6:00 am-1:48 pm

1 stop6h 48m

Fort Myers SW Florida Intl

Wed 10/22

4:44 pm-11:23 pm

2 stops7h 39m

$256

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

Wed 9/24

6:30 pm-12:29 am

1 stop4h 59m

Fort Myers SW Florida Intl

Mon 9/29

6:15 pm-10:37 pm

1 stop5h 22m

$264

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

Mon 9/15

11:35 am-8:18 pm

1 stop7h 43m

Fort Myers SW Florida Intl

Thu 9/18

9:15 am-2:20 pm

1 stop6h 05m

$277

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

Fri 11/21

1:56 pm-6:00 pm

Nonstop3h 04m

Fort Myers SW Florida Intl

Mon 11/24

6:50 pm-9:09 pm

Nonstop3h 19m

$291

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

Thu 1/22

5:15 pm-12:37 am

1 stop6h 22m

Fort Myers SW Florida Intl

Sat 1/31

5:40 pm-10:28 pm

1 stop5h 48m

$295

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

Thu 11/6

6:15 pm-11:35 pm

1 stop4h 20m

Fort Myers SW Florida Intl

Sun 11/9

7:45 pm-11:35 pm

1 stop4h 50m

$317

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

Fri 11/14

8:00 am-6:25 pm

2 stops9h 25m

Fort Myers SW Florida Intl

Mon 11/17

7:50 am-11:25 am

1 stop4h 35m

$322

Des MoinesFort Myers

DSM - RSW

DSMRSW

Des Moines

Sat 12/13

8:00 am-2:46 pm

1 stop5h 46m

Fort Myers SW Florida Intl

Mon 12/29

2:29 pm-9:40 pm

1 stop8h 11m

$341

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Fort Myers from

How to get the cheapest flight ticket from Des Moines to Fort Myers

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Fort Myers?

In general, August is the cheapest month to fly from Des Moines to Fort Myers. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $316. If you are unable to visit Fort Myers during the month of August, then departing from Des Moines during the month September is also very affordable. Most momondo users find prices during this month for around $347.

What is the cheapest day to depart on your flight to Fort Myers?

The cheapest day to depart from Des Moines to Fort Myers is on a Tuesday when prices can be found for as low as $376. Flights from Des Moines to Fort Myers on a Sunday will generally be more expensive and average around $461. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Fort Myers?

The cheapest time of day to fly to Fort Myers is in the afternoon when flights can be purchased for as low as $386. Flights in the morning are often more expensive with an average ticket price of $442.

How far in advance should I book a flight to Fort Myers?

You are more likely to see cheaper flights to Fort Myers from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Fort Myers for around $403 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Fort Myers from Des Moines for as low as $316 on momondo.

How have Des Moines to Fort Myers flight prices changed over time?

As of August 2025, prices for Des Moines to Fort Myers flights are approximately 4% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Fort Myers

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Fort Myers according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Fort Myers (DSM to RSW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Fort Myers

Best Price Found

$109

Fastest flight time

3h 04m

Direct flights

Sat

Airports in Fort Myers

1 airport
The best one-way flight to Fort Myers from Des Moines in the past 72 hours is $109. The best round-trip flight deal from Des Moines to Fort Myers found on momondo in the last 72 hours is $237.
The fastest flight from Des Moines to Fort Myers takes 3h 04m
Direct flights go from Des Moines to Fort Myers on Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport near Fort Myers: Fort Myers SW Florida Intl (RSW)
Search flight deals

  • How far is Des Moines to Fort Myers SW Florida Intl by plane?

    A flight from Des Moines to Fort Myers SW Florida Intl will travel around 1228.7 mi. A reasonable flight in good conditions will take 3h 04m.

  • When did momondo last update prices for flights from Des Moines Airport to Fort Myers SW Florida Intl Airport?

    Prices for flights from Des Moines Airport to Fort Myers SW Florida Intl Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Fort Myers SW Florida Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Fort Myers SW Florida Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Fort Myers SW Florida Intl Airport.

  • What documentation or ID do you need to fly to Fort Myers SW Florida Intl Airport?

    The necessary travel and health documents for your Fort Myers SW Florida Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Fort Myers?

  • What is the most popular airline from Des Moines to Fort Myers?

Best airlines flying from Des Moines to Fort Myers

Compare and see reviews for airlines that fly from Des Moines to Fort Myers with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $107Free CancellationRating
7.2
701 reviews
Search Allegiant Air flights
United AirlinesPriceFrom $276Free CancellationRating
7.4
8,916 reviews
Search United Airlines flights
DeltaPriceFrom $284Free CancellationRating
8.0
7,985 reviews
Search Delta flights
SouthwestPriceFrom $301Free CancellationRating
8.0
4,246 reviews
Search Southwest flights
American AirlinesPriceFrom $306Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
Sanibel
Fort Myers Beach
Cape Coral
Captiva
Estero
North Fort Myers
Boca Grande
Lehigh Acres

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Fort Myers?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Fort Myers from Des Moines.

Can I find flights from Des Moines to Fort Myers with flexible booking policies on momondo?

momondo does allow users to show only those flights to Fort Myers from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Fort Myers?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Fort Myers from Des Moines.

I’m not ready to book a flight from Des Moines to Fort Myers right now. Can momondo alert me if prices change?

Price alerts on flights to Fort Myers from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Fort Myers trip

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