Cheap flights from Des Moines to Fort Myers from $55

In general, September is the cheapest month to fly from Des Moines to Fort Myers. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $158. If you are unable to visit Fort Myers during the month of September, then departing from Des Moines during the month May is also very affordable. Most momondo users find prices during this month for around $225.

The cheapest day to depart from Des Moines to Fort Myers is on a Monday when prices can be found for as low as $200. Flights from Des Moines to Fort Myers on a Wednesday will generally be more expensive and average around $488. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

The cheapest time of day to fly to Fort Myers is in the afternoon when flights can be purchased for as low as $147. Flights in the morning are often more expensive with an average ticket price of $242.

Fly from Des Moines to Fort Myers SW Florida Intl for the best Des Moines - Fort Myers SW Florida Intl flight prices

You are more likely to see cheaper flights to Fort Myers from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Fort Myers for around $306 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Fort Myers from Des Moines for as low as $224 on momondo.

There is only 1 cabin class available to choose from on Des Moines to Fort Myers flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 2% on your flight if you consider stops on a Des Moines to Fort Myers flight.

As of August 2026, prices for Des Moines to Fort Myers flights are approximately 48% more expensive when compared to flights at the same time last year.

United Airlines and Delta are the most popular carriers operating from Des Moines to Fort Myers SW Florida Intl

Allegiant Air, American Airlines and Delta are the top three most popular airlines that fly to Fort Myers from Des Moines according to our data. Allegiant Air is the first choice among our users, with 68% of people opting to fly with this airline when traveling to Fort Myers. Keep in mind that there are 5 different airlines that fly to Fort Myers on a routine basis, so you have a few additional options to choose from.

Chicago (MDW) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Washington, D.C. (DCA) offer the lowest average round-trip price of $333.

Flights connecting via Washington, D.C. (DCA) have the shortest average one-way travel time: 6h 16m.

Washington, D.C. (DCA) has the shortest average layover time for this route: 2h 03m.