Cheap flights from Des Moines to Houston from $55

The month of July is, on average, the cheapest month to fly to Houston from Des Moines, with most prices found around $227. The month of May is another great option to travel to Houston, with average flight prices from Des Moines averaging around $228.

On average, the least expensive day to fly to Houston from Des Moines is on a Sunday. momondo users have found tickets for Sunday departures for as low as $84. However, this price may fluctuate depending on the airline, the season, and holidays. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Houston on Friday is $136.

Our data shows that the cheapest Des Moines to Houston flights are usually those with departure times in the afternoon. Our users have found flights to Houston in the afternoon for as low as $455. Try not to purchase tickets in the morning because they tend to be around $552. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Des Moines to Houston Hobby for the best Des Moines - Houston flight prices

You are more likely to see cheaper flights to Houston from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Houston for around $281 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Houston from Des Moines for as low as $204 on momondo.

There are 4 cabin classes available to choose from on Des Moines to Houston flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Frontier and Southwest are the most popular carriers operating from Des Moines to Houston

United Airlines, American Airlines and Allegiant Air are the top three most popular airlines that fly to Houston from Des Moines according to our data. United Airlines is the first choice among our users, with 72% of people opting to fly with this airline when traveling to Houston. Keep in mind that there are 5 different airlines that fly to Houston on a routine basis, so you have a few additional options to choose from.

As of April 2026, there are 4 flights per day flying from Des Moines to Houston. The most common time of day flights depart is 2:00PM, with 50% of flights taking off at noon.

As of April 2026, there are 32 flights per week flying from Des Moines to Houston. The most common day of the week flights depart is Mon, with 16% of flights taking off on this day.