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Cheap flights from Des Moines to Los Angeles from $108

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
2:48 pm - 4:43 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 55mnonstop
Allegiant Air Logo
5:33 pm - 10:54 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 21mnonstop
$141Allegiant Air
Mon, Jan 18 - Fri, Jan 22
Allegiant Air Logo
2:48 pm - 4:43 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 55mnonstop
Allegiant Air Logo
5:33 pm - 10:54 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 21mnonstop
$156Allegiant Air
Mon, Jan 18 - Fri, Jan 22
Multiple Airlines Logo
2:42 pm - 2:08 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
25h 26m2 stops Las Vegas Harry Reid Intl Phoenix Sky Harbor Intl
Multiple Airlines Logo
4:46 pm - 10:01 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 15mnonstop
$279Multiple Airlines
Wed, Oct 21 - Thu, Oct 22
Multiple Airlines Logo
12:35 pm - 7:11 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
8h 36m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
4:50 pm - 10:07 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 17mnonstop
$281Multiple Airlines
Thu, Nov 5 - Thu, Nov 12
United Airlines Logo
5:03 pm - 10:14 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
7h 11m1 stop Denver Intl
United Airlines Logo
2:03 pm - 11:28 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
7h 25m1 stop Chicago O'Hare Intl
$350United Airlines
Tue, Feb 2 - Sat, Feb 13
American Airlines Logo
5:00 am - 11:52 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
8h 52m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
2:57 pm - 11:23 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
6h 26m1 stop Dallas/Fort Worth
$355American Airlines
Thu, Nov 19 - Mon, Nov 23
American Airlines Logo
8:10 am - 12:35 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
6h 25m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
12:40 pm - 8:59 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
6h 19m1 stop Phoenix Sky Harbor Intl
$355American Airlines
Wed, Dec 9 - Mon, Dec 14
United Airlines Logo
5:12 pm - 9:19 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
6h 07m1 stop Denver Intl
United Airlines Logo
11:10 am - 8:36 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
7h 26m1 stop Denver Intl
$355United Airlines
Thu, Oct 29 - Sat, Oct 31
Southwest Logo
7:00 am - 10:05 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
5h 05m1 stop Denver Intl
Southwest Logo
12:10 pm - 8:45 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
6h 35m1 stop Denver Intl
$355Southwest
Wed, Dec 9 - Wed, Dec 16
Southwest Logo
7:00 am - 12:30 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
7h 30m2 stops Denver Intl Sacramento Intl
Southwest Logo
8:35 am - 5:50 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
7h 15m1 stop Las Vegas Harry Reid Intl
$360Southwest
Wed, Dec 9 - Wed, Dec 16

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Allegiant Air flights from Des Moines to Santa Ana, California

Our best Allegiant Air deals on Des Moines to Santa Ana, California flight tickets
Allegiant Air
Jan 18
DSM2:48 pmDes Moines
3h 55m
SNA4:43 pmSanta Ana J. Wayne/Orange Cnty
Jan 22
SNA5:33 pmSanta Ana J. Wayne/Orange Cnty
3h 21m
DSM10:54 pmDes Moines
$141
Allegiant Air
Jan 18
DSM2:48 pmDes Moines
3h 55m
SNA4:43 pmSanta Ana J. Wayne/Orange Cnty
Jan 22
SNA5:33 pmSanta Ana J. Wayne/Orange Cnty
3h 21m
DSM10:54 pmDes Moines
$156
Allegiant Air
Nov 5
DSM2:22 pmDes Moines
3h 38m
SNA4:00 pmSanta Ana J. Wayne/Orange Cnty
Nov 12
SNA4:50 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM10:07 pmDes Moines
$207

American Airlines flights from Des Moines to Santa Ana, California

Our best American Airlines deals on Des Moines to Santa Ana, California flight tickets
American Airlines
Oct 16
DSM11:22 amDes Moines
10h 55m
1 stop
SNA8:17 pmSanta Ana J. Wayne/Orange Cnty
Oct 18
SNA7:45 amSanta Ana J. Wayne/Orange Cnty
8h 14m
1 stop
DSM5:59 pmDes Moines
$597
American Airlines
Oct 19
DSM5:06 amDes Moines
5h 59m
1 stop
SNA9:05 amSanta Ana J. Wayne/Orange Cnty
Oct 25
SNA7:31 pmSanta Ana J. Wayne/Orange Cnty
11h 25m
2 stops
DSM8:56 amDes Moines
$636
American Airlines
Oct 19
DSM7:08 amDes Moines
13h 23m
2 stops
SNA6:31 pmSanta Ana J. Wayne/Orange Cnty
Oct 25
SNA7:31 pmSanta Ana J. Wayne/Orange Cnty
11h 25m
2 stops
DSM8:56 amDes Moines
$734

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Mon 1/18

2:48 pm-4:43 pm

Nonstop3h 55m

Santa Ana J. Wayne/Orange Cnty

Fri 1/22

5:33 pm-10:54 pm

Nonstop3h 21m

$141

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Mon 1/18

2:48 pm-4:43 pm

Nonstop3h 55m

Santa Ana J. Wayne/Orange Cnty

Fri 1/22

5:33 pm-10:54 pm

Nonstop3h 21m

$156

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Wed 10/21

2:42 pm-2:08 pm

2 stops25h 26m

Santa Ana J. Wayne/Orange Cnty

Thu 10/22

4:46 pm-10:01 pm

Nonstop3h 15m

$279

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Thu 11/5

12:35 pm-7:11 pm

1 stop8h 36m

Santa Ana J. Wayne/Orange Cnty

Thu 11/12

4:50 pm-10:07 pm

Nonstop3h 17m

$281

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Tue 2/2

5:03 pm-10:14 pm

1 stop7h 11m

Santa Ana J. Wayne/Orange Cnty

Sat 2/13

2:03 pm-11:28 pm

1 stop7h 25m

$350

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Thu 11/19

5:00 am-11:52 am

1 stop8h 52m

Santa Ana J. Wayne/Orange Cnty

Mon 11/23

2:57 pm-11:23 pm

1 stop6h 26m

$355

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Wed 12/9

8:10 am-12:35 pm

1 stop6h 25m

Santa Ana J. Wayne/Orange Cnty

Mon 12/14

12:40 pm-8:59 pm

1 stop6h 19m

$355

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Thu 10/29

5:12 pm-9:19 pm

1 stop6h 07m

Santa Ana J. Wayne/Orange Cnty

Sat 10/31

11:10 am-8:36 pm

1 stop7h 26m

$355

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Wed 12/9

7:00 am-10:05 am

1 stop5h 05m

Santa Ana J. Wayne/Orange Cnty

Wed 12/16

12:10 pm-8:45 pm

1 stop6h 35m

$355

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Wed 12/9

7:00 am-12:30 pm

2 stops7h 30m

Santa Ana J. Wayne/Orange Cnty

Wed 12/16

8:35 am-5:50 pm

1 stop7h 15m

$360

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Santa Ana, California?

Prices are currently low for flights on this route.

Typical prices usually range from $175 to $373.
The lowest price recently found on this route was $141.

What is the cheapest month to fly to Santa Ana, California?

In general, January is the cheapest month to fly from Des Moines to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $164. If you aren’t able to travel during the month of January, then book flights to Santa Ana, California from Des Moines during September instead. Flights to Santa Ana, California in September, while not as cheap as those in January, still average around $189.

What is the cheapest day to depart on your flight to Santa Ana, California?

The cheapest day to depart from Des Moines to Santa Ana, California is on a Monday. Travelers who choose to depart for Santa Ana, California on a Monday will often find tickets for as low as $192. The most expensive day to fly to Santa Ana, California is Tuesday, with ticket prices averaging around $373.

What is the cheapest time of day to depart on your flight to Santa Ana, California?

In the afternoon is the cheapest time of day to fly from Des Moines to Santa Ana, California when you can find flight prices for as low as $163. Flying to Santa Ana, California in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Santa Ana, California is in the morning when prices are around $227.

What is the cheapest Des Moines to Santa Ana J. Wayne/Orange Cnty flight route?

Fly from Des Moines to Santa Ana J. Wayne/Orange Cnty for the best Des Moines - Santa Ana J. Wayne/Orange Cnty flight prices

How far in advance should I book a flight from Des Moines to Santa Ana, California?

You are more likely to see cheaper flights to Santa Ana, California from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $323 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from Des Moines for as low as $174 on momondo.

What cabin class options are available on Des Moines to Santa Ana, California flights?

There is only 1 cabin class available to choose from on Des Moines to Santa Ana, California flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Des Moines to Santa Ana, California flight prices changed over time?

As of October 2026, prices for Des Moines to Santa Ana, California flights are approximately 1% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Ana, California (DSM to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Ana, California

Best Price Found

$108

Fastest flight time

3h 38m

Direct flights

Mon, Tue, Thu, Fri and Sun

Airports in Santa Ana, California

1 airport
The best one-way flight to Santa Ana, California from Des Moines in the past 72 hours is $108. The best round-trip flight deal from Des Moines to Santa Ana, California found on momondo in the last 72 hours is $141.
The fastest flight from Des Moines to Santa Ana, California takes 3h 38m
Direct flights go from Des Moines to Santa Ana, California on Monday, Tuesday, Thursday, Friday and Sunday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Santa Ana, California. From Des Moines there are direct flights to Santa Ana J. Wayne/Orange Cnty (SNA).
Search flight deals

Frequently asked questions about flying from Des Moines to Santa Ana, California

  • How far is Des Moines to Santa Ana J. Wayne/Orange Cnty by plane?

    The straight-line distance from Des Moines to Santa Ana J. Wayne/Orange Cnty is 1425.0 mi. Flights usually cover this in 3h 38m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The travel and health documents you'll need for your trip to Santa Ana J. Wayne/Orange Cnty Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Santa Ana, California?

  • What is the most popular airline from Des Moines to Santa Ana, California?

Best airlines flying from Des Moines to Santa Ana, California

Compare and see reviews for airlines that fly from Des Moines to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $124Free CancellationRating
7.3
679 reviews
Search Allegiant Air flights
United AirlinesPriceFrom $268Free CancellationRating
7.4
10,280 reviews
Search United Airlines flights
American AirlinesPriceFrom $294Free CancellationRating
7.0
12,132 reviews
Search American Airlines flights
SouthwestPriceFrom $341Free CancellationRating
8.0
4,214 reviews
Search Southwest flights

  • Allegiant Air Flights From Des Moines to Santa Ana, California

    Across 1 Allegiant Air flight from Des Moines to Santa Ana, California this week, the average price was $226, with the best Allegiant Air deals starting from $124 round-trip. 679 users have rated Allegiant Air on momondo, with an average score of 7.3/10.

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
Tustin

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Santa Ana for you.

Can I find flights from Des Moines to Santa Ana with flexible booking policies on momondo?

Yes. All flights to Santa Ana from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Santa Ana?

momondo helps you find the best flight between Des Moines and Santa Ana by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Santa Ana right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Santa Ana flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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