Cheap flights from Des Moines to Los Angeles from $94

In general, January is the cheapest month to fly from Des Moines to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $158. If you aren’t able to travel during the month of January, then book flights to Santa Ana, California from Des Moines during September instead. Flights to Santa Ana, California in September, while not as cheap as those in January, still average around $189.

The cheapest day to depart from Des Moines to Santa Ana, California is on a Monday. Travelers who choose to depart for Santa Ana, California on a Monday will often find tickets for as low as $186. The most expensive day to fly to Santa Ana, California is Tuesday, with ticket prices averaging around $373.

In the afternoon is the cheapest time of day to fly from Des Moines to Santa Ana, California when you can find flight prices for as low as $163. Flying to Santa Ana, California in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Santa Ana, California is in the morning when prices are around $226.

Fly from Des Moines to Santa Ana J. Wayne/Orange Cnty for the best Des Moines - Santa Ana J. Wayne/Orange Cnty flight prices

You are more likely to see cheaper flights to Santa Ana, California from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $319 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from Des Moines for as low as $174 on momondo.

There is only 1 cabin class available to choose from on Des Moines to Santa Ana, California flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Des Moines to Santa Ana, California.

As of October 2026, prices for Des Moines to Santa Ana, California flights are approximately 1% cheaper when compared to flights at the same time last year.

Allegiant Air and United Airlines are the most popular carriers operating from Des Moines to Santa Ana J. Wayne/Orange Cnty

American Airlines, Allegiant Air and Southwest are the top three most popular airlines that fly to Santa Ana, California from Des Moines according to our data. American Airlines is the first choice among our users, with 55% of people opting to fly with this airline when traveling to Santa Ana, California. Keep in mind that there are 7 different airlines that fly to Santa Ana, California on a routine basis, so you have a few additional options to choose from.