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Cheap flights from Des Moines to Los Angeles from $64

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Los Angeles departing on 11/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Los Angeles

Cheap round-trip flights

Allegiant Air Logo
8:00 am - 9:35 amDSM-SNA
3h 35mnonstop
Allegiant Air Logo
10:25 am - 3:44 pmSNA-DSM
3h 19mnonstop
$150Allegiant Air
Find Deal
Thu, Oct 9 - Sun, Oct 12
Allegiant Air Logo
9:00 am - 10:35 amDSM-SNA
3h 35mnonstop
Allegiant Air Logo
11:25 am - 4:44 pmSNA-DSM
3h 19mnonstop
$164Allegiant Air
Find Deal
Thu, Oct 30 - Sun, Nov 2
Multiple Airlines Logo
9:00 am - 10:35 amDSM-SNA
3h 35mnonstop
Multiple Airlines Logo
3:01 pm - 1:47 pmSNA-DSM
20h 46m1 stop
$186Multiple Airlines
Find Deal
Sun, Nov 2 - Wed, Nov 5
Multiple Airlines Logo
3:40 pm - 10:03 pmDSM-SNA
8h 23m1 stop
Multiple Airlines Logo
11:25 am - 4:44 pmSNA-DSM
3h 19mnonstop
$195Multiple Airlines
Find Deal
Mon, Oct 27 - Thu, Oct 30
Frontier Logo
2:32 pm - 11:16 amDSM-SNA
22h 44m1 stop
Frontier Logo
7:11 pm - 1:47 pmSNA-DSM
16h 36m2 stops
$241Frontier
Find Deal
Thu, Oct 30 - Sun, Nov 2
Southwest Logo
12:55 pm - 6:05 pmDSM-SNA
7h 10m1 stop
Southwest Logo
12:45 pm - 7:55 pmSNA-DSM
5h 10m1 stop
$261Southwest
Find Deal
Sat, Nov 1 - Wed, Nov 5
Southwest Logo
12:55 pm - 6:05 pmDSM-SNA
7h 10m1 stop
Southwest Logo
10:30 am - 7:55 pmSNA-DSM
7h 25m2 stops
$266Southwest
Find Deal
Sat, Nov 1 - Wed, Nov 5
Frontier Logo
2:32 pm - 11:16 amDSM-SNA
22h 44m1 stop
Frontier Logo
8:16 pm - 1:47 pmSNA-DSM
15h 31m2 stops
$283Frontier
Find Deal
Thu, Nov 6 - Sun, Nov 9
American Airlines Logo
5:00 am - 9:53 amDSM-SNA
6h 53m1 stop
American Airlines Logo
7:45 am - 6:10 pmSNA-DSM
8h 25m1 stop
$301American Airlines
Find Deal
Thu, Nov 13 - Tue, Nov 18
American Airlines Logo
2:16 pm - 8:43 pmDSM-SNA
8h 27m1 stop
American Airlines Logo
12:30 pm - 10:59 pmSNA-DSM
8h 29m2 stops
$306American Airlines
Find Deal
Thu, Nov 13 - Tue, Nov 18

American Airlines flights from Des Moines to Santa Ana

Our best American Airlines deals on Des Moines to Santa Ana flight tickets
American Airlines
Nov 13
DSM5:00 amDes Moines
6h 53m
1 stop
SNA9:53 amSanta Ana J. Wayne/Orange Cnty
Nov 18
SNA7:45 amSanta Ana J. Wayne/Orange Cnty
8h 25m
1 stop
DSM6:10 pmDes Moines
$301
Find similar
American Airlines
Nov 13
DSM2:16 pmDes Moines
8h 27m
1 stop
SNA8:43 pmSanta Ana J. Wayne/Orange Cnty
Nov 18
SNA12:30 pmSanta Ana J. Wayne/Orange Cnty
8h 29m
2 stops
DSM10:59 pmDes Moines
$306
Find similar
American Airlines
Nov 18
DSM11:30 amDes Moines
8h 54m
2 stops
SNA6:24 pmSanta Ana J. Wayne/Orange Cnty
Nov 22
SNA3:08 pmSanta Ana J. Wayne/Orange Cnty
6h 33m
1 stop
DSM11:41 pmDes Moines
$307
Find similar

Allegiant Air flights from Des Moines to Santa Ana

Our best Allegiant Air deals on Des Moines to Santa Ana flight tickets
Allegiant Air
Oct 9
DSM8:00 amDes Moines
3h 35m
SNA9:35 amSanta Ana J. Wayne/Orange Cnty
Oct 12
SNA10:25 amSanta Ana J. Wayne/Orange Cnty
3h 19m
DSM3:44 pmDes Moines
$150
Find similar
Allegiant Air
Oct 30
DSM9:00 amDes Moines
3h 35m
SNA10:35 amSanta Ana J. Wayne/Orange Cnty
Nov 2
SNA11:25 amSanta Ana J. Wayne/Orange Cnty
3h 19m
DSM4:44 pmDes Moines
$164
Find similar
Allegiant Air
Sep 25
DSM8:00 amDes Moines
3h 43m
SNA9:43 amSanta Ana J. Wayne/Orange Cnty
Sep 28
SNA10:33 amSanta Ana J. Wayne/Orange Cnty
3h 15m
DSM3:48 pmDes Moines
$188
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Santa Ana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 10/9

8:00 am-9:35 am

Nonstop3h 35m

Santa Ana J. Wayne/Orange Cnty

Sun 10/12

10:25 am-3:44 pm

Nonstop3h 19m

$150

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 10/30

9:00 am-10:35 am

Nonstop3h 35m

Santa Ana J. Wayne/Orange Cnty

Sun 11/2

11:25 am-4:44 pm

Nonstop3h 19m

$164

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sun 11/2

9:00 am-10:35 am

Nonstop3h 35m

Santa Ana J. Wayne/Orange Cnty

Wed 11/5

3:01 pm-1:47 pm

1 stop20h 46m

$186

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 10/27

3:40 pm-10:03 pm

1 stop8h 23m

Santa Ana J. Wayne/Orange Cnty

Thu 10/30

11:25 am-4:44 pm

Nonstop3h 19m

$195

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 10/30

2:32 pm-11:16 am

1 stop22h 44m

Santa Ana J. Wayne/Orange Cnty

Sun 11/2

7:11 pm-1:47 pm

2 stops16h 36m

$241

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 11/1

12:55 pm-6:05 pm

1 stop7h 10m

Santa Ana J. Wayne/Orange Cnty

Wed 11/5

12:45 pm-7:55 pm

1 stop5h 10m

$261

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 11/1

12:55 pm-6:05 pm

1 stop7h 10m

Santa Ana J. Wayne/Orange Cnty

Wed 11/5

10:30 am-7:55 pm

2 stops7h 25m

$266

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 11/6

2:32 pm-11:16 am

1 stop22h 44m

Santa Ana J. Wayne/Orange Cnty

Sun 11/9

8:16 pm-1:47 pm

2 stops15h 31m

$283

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 11/13

5:00 am-9:53 am

1 stop6h 53m

Santa Ana J. Wayne/Orange Cnty

Tue 11/18

7:45 am-6:10 pm

1 stop8h 25m

$301

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 11/13

2:16 pm-8:43 pm

1 stop8h 27m

Santa Ana J. Wayne/Orange Cnty

Tue 11/18

12:30 pm-10:59 pm

2 stops8h 29m

$306

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Santa Ana

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Santa Ana?

What is the cheapest month to fly to Santa Ana?

The cheapest month to fly to Santa Ana from Des Moines is in September. Flight prices, which tend to average around $131, are often lower during this time because this is during the off-season. The month of April is another great option to travel to Santa Ana, with average flight prices from Des Moines averaging around $240.

What is the cheapest day to depart on your flight to Santa Ana?

On average, the least expensive day to fly to Santa Ana from Des Moines is on a Sunday. momondo users have found tickets for Sunday departures for as low as $148. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Friday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $415.

What is the cheapest time of day to depart on your flight to Santa Ana?

Our data shows that the cheapest Des Moines to Santa Ana flights are usually those with departure times in the afternoon. Our users have found flights to Santa Ana in the afternoon for as low as $139. Try not to purchase tickets in the morning because they tend to be around $225. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Des Moines to Santa Ana J. Wayne/Orange Cnty flight route?

Fly from Des Moines to Santa Ana J. Wayne/Orange Cnty for the best Des Moines - Santa Ana J. Wayne/Orange Cnty flight prices

How far in advance should I book a flight to Santa Ana?

You are more likely to see cheaper flights to Santa Ana from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana for around $324 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana from Des Moines for as low as $134 on momondo.

What cabin class options are available on Des Moines to Santa Ana J. Wayne/Orange Cnty flights?

There is only 1 cabin class available to choose from on Des Moines to Santa Ana J. Wayne/Orange Cnty flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Santa Ana flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Santa Ana.

How have Des Moines to Santa Ana flight prices changed over time?

As of September 2025, prices for Des Moines to Santa Ana flights are approximately 111% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Santa Ana

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Ana according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Ana (DSM to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Ana

Best Price Found

$77

Fastest flight time

3h 35m

Direct flights

Mon, Fri and Sat

Airports in Santa Ana

1 airport
The best one-way flight to Santa Ana from Des Moines in the past 72 hours is $77. The best round-trip flight deal from Des Moines to Santa Ana found on momondo in the last 72 hours is $105.
The fastest flight from Des Moines to Santa Ana takes 3h 35m
Direct flights go from Des Moines to Santa Ana on Monday, Friday and Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport near Santa Ana: Santa Ana J. Wayne/Orange Cnty (SNA)
Search flight deals

  • How far is Des Moines to Santa Ana J. Wayne/Orange Cnty by plane?

    The straight-line distance from Des Moines to Santa Ana J. Wayne/Orange Cnty is 1425.0 mi. Flights usually cover this in 3h 35m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The travel and health documents you'll need for your trip to Santa Ana J. Wayne/Orange Cnty Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Santa Ana?

  • What is the most popular airline from Des Moines to Santa Ana?

Best airlines flying from Des Moines to Santa Ana

Compare and see reviews for airlines that fly from Des Moines to Santa Ana with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $108Free CancellationRating
7.2
699 reviews
Search Allegiant Air flights
DeltaPriceFrom $130Free CancellationRating
7.9
7,961 reviews
Search Delta flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $298Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
SouthwestPriceFrom $382Free CancellationRating
8.0
4,242 reviews
Search Southwest flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
Tustin

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Santa Ana for you.

Can I find flights from Des Moines to Santa Ana with flexible booking policies on momondo?

Yes. All flights to Santa Ana from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Santa Ana?

momondo helps you find the best flight between Des Moines and Santa Ana by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Santa Ana right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Santa Ana flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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