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Cheap flights from Des Moines to Los Angeles from $69

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
2:18 pm - 3:56 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 38mnonstop
Allegiant Air Logo
4:46 pm - 10:01 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 15mnonstop
$147Allegiant Air
Thu, Oct 29 - Sun, Nov 1
Allegiant Air Logo
10:00 am - 11:37 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
3h 37mnonstop
Allegiant Air Logo
12:27 pm - 5:44 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 17mnonstop
$147Allegiant Air
Sun, Sep 20 - Sun, Sep 27
Multiple Airlines Logo
1:20 pm - 3:03 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
27h 43m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
11:45 am - 5:06 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 21mnonstop
$214Multiple Airlines
Mon, Jan 4 - Fri, Jan 8
Multiple Airlines Logo
9:56 pm - 5:15 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
21h 19m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
12:27 pm - 5:44 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
3h 17mnonstop
$220Multiple Airlines
Sun, Sep 20 - Sun, Sep 27
American Airlines Logo
5:05 am - 9:04 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
5h 59m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
3:24 pm - 12:14 amSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
6h 50m1 stop Chicago O'Hare Intl
$355American Airlines
Thu, Nov 5 - Mon, Nov 9
American Airlines Logo
5:06 am - 9:05 amDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
5h 59m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
4:30 pm - 11:45 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
5h 15m1 stop Phoenix Sky Harbor Intl
$355American Airlines
Wed, Oct 14 - Mon, Oct 19
United Airlines Logo
5:21 pm - 8:44 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
5h 23m1 stop Denver Intl
United Airlines Logo
6:45 am - 5:28 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
8h 43m1 stop Chicago O'Hare Intl
$355United Airlines
Tue, Sep 8 - Tue, Sep 15
Southwest Logo
6:20 am - 1:00 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
8h 40m2 stops Denver Intl Sacramento Intl
Southwest Logo
9:25 am - 6:35 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
7h 10m1 stop Phoenix Sky Harbor Intl
$360Southwest
Thu, Oct 29 - Mon, Nov 2
Southwest Logo
7:05 am - 1:20 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
8h 15m2 stops Denver Intl Las Vegas Harry Reid Intl
Southwest Logo
6:45 am - 2:20 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
5h 35m1 stop Denver Intl
$360Southwest
Tue, Oct 20 - Tue, Oct 27
United Airlines Logo
5:12 pm - 9:03 pmDSM  Des Moines-SNA Santa Ana J. Wayne/Orange Cnty
5h 51m1 stop Denver Intl
United Airlines Logo
11:30 am - 11:01 pmSNA  Santa Ana J. Wayne/Orange Cnty-DSM Des Moines
9h 31m2 stops Denver Intl Chicago O'Hare Intl
$411United Airlines
Mon, Jan 4 - Sat, Jan 9

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Allegiant Air flights from Des Moines to Santa Ana, California

Our best Allegiant Air deals on Des Moines to Santa Ana, California flight tickets
Allegiant Air
Sep 20
DSM10:00 amDes Moines
3h 37m
SNA11:37 amSanta Ana J. Wayne/Orange Cnty
Sep 27
SNA12:27 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM5:44 pmDes Moines
$147
Allegiant Air
Jan 4
DSM2:32 pmDes Moines
3h 50m
SNA4:22 pmSanta Ana J. Wayne/Orange Cnty
Jan 8
SNA11:45 amSanta Ana J. Wayne/Orange Cnty
3h 21m
DSM5:06 pmDes Moines
$150
Allegiant Air
Oct 29
DSM2:18 pmDes Moines
3h 38m
SNA3:56 pmSanta Ana J. Wayne/Orange Cnty
Nov 1
SNA4:46 pmSanta Ana J. Wayne/Orange Cnty
3h 15m
DSM10:01 pmDes Moines
$155

United Airlines flights from Des Moines to Santa Ana, California

Our best United Airlines deals on Des Moines to Santa Ana, California flight tickets
United Airlines
Sep 2
DSM5:21 pmDes Moines
5h 23m
1 stop
SNA8:44 pmSanta Ana J. Wayne/Orange Cnty
Sep 6
SNA10:20 amSanta Ana J. Wayne/Orange Cnty
9h 03m
1 stop
DSM9:23 pmDes Moines
$466
United Airlines
Sep 3
DSM6:15 amDes Moines
6h 47m
1 stop
SNA11:02 amSanta Ana J. Wayne/Orange Cnty
Sep 8
SNA4:14 pmSanta Ana J. Wayne/Orange Cnty
5h 19m
1 stop
DSM11:33 pmDes Moines
$556
United Airlines
Sep 3
DSM6:15 amDes Moines
6h 47m
1 stop
SNA11:02 amSanta Ana J. Wayne/Orange Cnty
Sep 8
SNA7:59 pmSanta Ana J. Wayne/Orange Cnty
12h 32m
2 stops
DSM10:31 amDes Moines
$561

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Thu 10/29

2:18 pm-3:56 pm

Nonstop3h 38m

Santa Ana J. Wayne/Orange Cnty

Sun 11/1

4:46 pm-10:01 pm

Nonstop3h 15m

$147

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Sun 9/20

10:00 am-11:37 am

Nonstop3h 37m

Santa Ana J. Wayne/Orange Cnty

Sun 9/27

12:27 pm-5:44 pm

Nonstop3h 17m

$147

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Mon 1/4

1:20 pm-3:03 pm

1 stop27h 43m

Santa Ana J. Wayne/Orange Cnty

Fri 1/8

11:45 am-5:06 pm

Nonstop3h 21m

$214

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Sun 9/20

9:56 pm-5:15 pm

1 stop21h 19m

Santa Ana J. Wayne/Orange Cnty

Sun 9/27

12:27 pm-5:44 pm

Nonstop3h 17m

$220

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Thu 11/5

5:05 am-9:04 am

1 stop5h 59m

Santa Ana J. Wayne/Orange Cnty

Mon 11/9

3:24 pm-12:14 am

1 stop6h 50m

$355

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Wed 10/14

5:06 am-9:05 am

1 stop5h 59m

Santa Ana J. Wayne/Orange Cnty

Mon 10/19

4:30 pm-11:45 pm

1 stop5h 15m

$355

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Tue 9/8

5:21 pm-8:44 pm

1 stop5h 23m

Santa Ana J. Wayne/Orange Cnty

Tue 9/15

6:45 am-5:28 pm

1 stop8h 43m

$355

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Thu 10/29

6:20 am-1:00 pm

2 stops8h 40m

Santa Ana J. Wayne/Orange Cnty

Mon 11/2

9:25 am-6:35 pm

1 stop7h 10m

$360

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Tue 10/20

7:05 am-1:20 pm

2 stops8h 15m

Santa Ana J. Wayne/Orange Cnty

Tue 10/27

6:45 am-2:20 pm

1 stop5h 35m

$360

Des MoinesSanta Ana

DSM Des Moines - SNA Santa Ana J. Wayne/Orange Cnty

DSMSNA

Des Moines

Mon 1/4

5:12 pm-9:03 pm

1 stop5h 51m

Santa Ana J. Wayne/Orange Cnty

Sat 1/9

11:30 am-11:01 pm

2 stops9h 31m

$411

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Santa Ana, California?

Prices are currently low for flights on this route.

Typical prices usually range from $193 to $416.
The lowest price recently found on this route was $147.

What is the cheapest month to fly to Santa Ana, California?

In general, January is the cheapest month to fly from Des Moines to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $164. If you aren’t able to travel during the month of January, then book flights to Santa Ana, California from Des Moines during September instead. Flights to Santa Ana, California in September, while not as cheap as those in January, still average around $173.

What is the cheapest day to depart on your flight to Santa Ana, California?

The cheapest day to depart from Des Moines to Santa Ana, California is on a Monday. Travelers who choose to depart for Santa Ana, California on a Monday will often find tickets for as low as $192. The most expensive day to fly to Santa Ana, California is Tuesday, with ticket prices averaging around $373.

What is the cheapest time of day to depart on your flight to Santa Ana, California?

In the afternoon is the cheapest time of day to fly from Des Moines to Santa Ana, California when you can find flight prices for as low as $163. Flying to Santa Ana, California in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Santa Ana, California is in the morning when prices are around $226.

What is the cheapest Des Moines to Santa Ana J. Wayne/Orange Cnty flight route?

Fly from Des Moines to Santa Ana J. Wayne/Orange Cnty for the best Des Moines - Santa Ana J. Wayne/Orange Cnty flight prices

How far in advance should I book a flight from Des Moines to Santa Ana, California?

You are more likely to see cheaper flights to Santa Ana, California from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $323 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from Des Moines for as low as $174 on momondo.

What cabin class options are available on Des Moines to Santa Ana, California flights?

There is only 1 cabin class available to choose from on Des Moines to Santa Ana, California flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Santa Ana, California flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Santa Ana, California.

How have Des Moines to Santa Ana, California flight prices changed over time?

As of August 2026, prices for Des Moines to Santa Ana, California flights are approximately 34% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Ana, California (DSM to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Ana, California

Best Price Found

$69

Fastest flight time

3h 36m

Direct flights

Mon, Tue, Thu, Fri and Sun

Airports in Santa Ana, California

1 airport
The best one-way flight to Santa Ana, California from Des Moines in the past 72 hours is $69. The best round-trip flight deal from Des Moines to Santa Ana, California found on momondo in the last 72 hours is $147.
The fastest flight from Des Moines to Santa Ana, California takes 3h 36m
Direct flights go from Des Moines to Santa Ana, California on Monday, Tuesday, Thursday, Friday and Sunday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Santa Ana, California. From Des Moines there are direct flights to Santa Ana J. Wayne/Orange Cnty (SNA).
Search flight deals

Frequently asked questions about flying from Des Moines to Santa Ana, California

  • How far is Des Moines to Santa Ana J. Wayne/Orange Cnty by plane?

    The straight-line distance from Des Moines to Santa Ana J. Wayne/Orange Cnty is 1425.0 mi. Flights usually cover this in 3h 36m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The travel and health documents you'll need for your trip to Santa Ana J. Wayne/Orange Cnty Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Santa Ana, California?

  • What is the most popular airline from Des Moines to Santa Ana, California?

Best airlines flying from Des Moines to Santa Ana, California

Compare and see reviews for airlines that fly from Des Moines to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $116Free CancellationRating
7.3
675 reviews
Search Allegiant Air flights
United AirlinesPriceFrom $268Free CancellationRating
7.4
10,103 reviews
Search United Airlines flights
American AirlinesPriceFrom $294Free CancellationRating
7.1
11,978 reviews
Search American Airlines flights
SouthwestPriceFrom $340Free CancellationRating
8.0
4,215 reviews
Search Southwest flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Santa Ana for you.

Can I find flights from Des Moines to Santa Ana with flexible booking policies on momondo?

Yes. All flights to Santa Ana from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Santa Ana?

momondo helps you find the best flight between Des Moines and Santa Ana by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Santa Ana right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Santa Ana flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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