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Cheap flights from Des Moines to Los Angeles from $91

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Los Angeles departing on 4/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Des Moines to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
9:45 am - 11:36 am
DSM
-
SNA
3h 51mnonstop
Allegiant Air Logo
12:41 pm - 5:58 pm
SNA
-
DSM
3h 17mnonstop
$114Allegiant Air
Fri, May 1 - Fri, May 8
Allegiant Air Logo
9:45 am - 11:36 am
DSM
-
SNA
3h 51mnonstop
Allegiant Air Logo
12:41 pm - 5:58 pm
SNA
-
DSM
3h 17mnonstop
$127Allegiant Air
Fri, May 1 - Fri, May 8
Allegiant Air Logo
10:00 am - 11:51 am
DSM
-
SNA
3h 51mnonstop
Allegiant Air Logo
10:32 am - 3:51 pm
SNA
-
DSM
3h 19mnonstop
$134Allegiant Air
Mon, May 11 - Thu, May 21
Allegiant Air Logo
10:00 am - 11:37 am
DSM
-
SNA
3h 37mnonstop
Allegiant Air Logo
12:27 pm - 5:44 pm
SNA
-
DSM
3h 17mnonstop
$188Allegiant Air
Sun, Sep 20 - Thu, Sep 24
Allegiant Air Logo
10:00 am - 11:37 am
DSM
-
SNA
3h 37mnonstop
Allegiant Air Logo
12:27 pm - 5:44 pm
SNA
-
DSM
3h 17mnonstop
$197Allegiant Air
Thu, Sep 17 - Sun, Sep 20
Multiple Airlines Logo
10:00 am - 11:51 am
DSM
-
SNA
3h 51mnonstop
Multiple Airlines Logo
4:33 pm - 8:52 pm
SNA
-
DSM
26h 19m
1 stop
$205Multiple Airlines
Mon, May 11 - Thu, May 21
Allegiant Air Logo
6:50 am - 8:41 am
DSM
-
SNA
3h 51mnonstop
Allegiant Air Logo
12:41 pm - 5:58 pm
SNA
-
DSM
3h 17mnonstop
$206Allegiant Air
Mon, Apr 13 - Fri, Apr 17
Multiple Airlines Logo
9:45 am - 11:36 am
DSM
-
SNA
3h 51mnonstop
Multiple Airlines Logo
7:45 am - 9:11 pm
SNA
-
DSM
11h 26m
1 stop
$209Multiple Airlines
Fri, May 1 - Fri, May 8
Multiple Airlines Logo
10:14 pm - 9:45 pm
DSM
-
SNA
25h 31m
1 stop
Multiple Airlines Logo
12:41 pm - 5:58 pm
SNA
-
DSM
3h 17mnonstop
$211Multiple Airlines
Fri, May 1 - Fri, May 8
Multiple Airlines Logo
9:17 pm - 3:23 pm
DSM
-
SNA
20h 06m
1 stop
Multiple Airlines Logo
9:28 am - 2:42 pm
SNA
-
DSM
3h 14mnonstop
$216Multiple Airlines
Mon, Jun 1 - Thu, Jun 4

Allegiant Air flights from Des Moines to Santa Ana, California

Our best Allegiant Air deals on Des Moines to Santa Ana, California flight tickets
Allegiant Air
May 1
DSM9:45 amDes Moines
3h 51m
SNA11:36 amSanta Ana J. Wayne/Orange Cnty
May 8
SNA12:41 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM5:58 pmDes Moines
$114
Allegiant Air
May 1
DSM9:45 amDes Moines
3h 51m
SNA11:36 amSanta Ana J. Wayne/Orange Cnty
May 8
SNA12:41 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM5:58 pmDes Moines
$127
Allegiant Air
May 11
DSM10:00 amDes Moines
3h 51m
SNA11:51 amSanta Ana J. Wayne/Orange Cnty
May 21
SNA10:32 amSanta Ana J. Wayne/Orange Cnty
3h 19m
DSM3:51 pmDes Moines
$134

American Airlines flights from Des Moines to Santa Ana, California

Our best American Airlines deals on Des Moines to Santa Ana, California flight tickets
American Airlines
May 12
DSM12:06 pmDes Moines
8h 23m
1 stop
SNA6:29 pmSanta Ana J. Wayne/Orange Cnty
May 19
SNA3:12 pmSanta Ana J. Wayne/Orange Cnty
6h 37m
1 stop
DSM11:49 pmDes Moines
$330
American Airlines
Apr 27
DSM2:38 pmDes Moines
5h 23m
1 stop
SNA6:01 pmSanta Ana J. Wayne/Orange Cnty
Apr 30
SNA3:12 pmSanta Ana J. Wayne/Orange Cnty
6h 37m
1 stop
DSM11:49 pmDes Moines
$331
American Airlines
Apr 14
DSM5:25 amDes Moines
8h 12m
1 stop
SNA11:37 amSanta Ana J. Wayne/Orange Cnty
Apr 21
SNA2:42 pmSanta Ana J. Wayne/Orange Cnty
6h 34m
1 stop
DSM11:16 pmDes Moines
$403

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Ana, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 1, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Fri 5/1

9:45 am-11:36 am

Nonstop3h 51m

Santa Ana J. Wayne/Orange Cnty

Fri 5/8

12:41 pm-5:58 pm

Nonstop3h 17m

$114

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Fri 5/1

9:45 am-11:36 am

Nonstop3h 51m

Santa Ana J. Wayne/Orange Cnty

Fri 5/8

12:41 pm-5:58 pm

Nonstop3h 17m

$127

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 5/11

10:00 am-11:51 am

Nonstop3h 51m

Santa Ana J. Wayne/Orange Cnty

Thu 5/21

10:32 am-3:51 pm

Nonstop3h 19m

$134
Quickest round-trip

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sun 9/20

10:00 am-11:37 am

Nonstop3h 37m

Santa Ana J. Wayne/Orange Cnty

Thu 9/24

12:27 pm-5:44 pm

Nonstop3h 17m

$188

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 9/17

10:00 am-11:37 am

Nonstop3h 37m

Santa Ana J. Wayne/Orange Cnty

Sun 9/20

12:27 pm-5:44 pm

Nonstop3h 17m

$197

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 5/11

10:00 am-11:51 am

Nonstop3h 51m

Santa Ana J. Wayne/Orange Cnty

Thu 5/21

4:33 pm-8:52 pm

1 stop26h 19m

$205

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 4/13

6:50 am-8:41 am

Nonstop3h 51m

Santa Ana J. Wayne/Orange Cnty

Fri 4/17

12:41 pm-5:58 pm

Nonstop3h 17m

$206

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Fri 5/1

9:45 am-11:36 am

Nonstop3h 51m

Santa Ana J. Wayne/Orange Cnty

Fri 5/8

7:45 am-9:11 pm

1 stop11h 26m

$209

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Fri 5/1

10:14 pm-9:45 pm

1 stop25h 31m

Santa Ana J. Wayne/Orange Cnty

Fri 5/8

12:41 pm-5:58 pm

Nonstop3h 17m

$211

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 6/1

9:17 pm-3:23 pm

1 stop20h 06m

Santa Ana J. Wayne/Orange Cnty

Thu 6/4

9:28 am-2:42 pm

Nonstop3h 14m

$216

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Santa Ana, California?

What is the cheapest month to fly to Santa Ana, California?

In general, September is the cheapest month to fly from Des Moines to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $131. If you aren’t able to travel during the month of September, then book flights to Santa Ana, California from Des Moines during January instead. Flights to Santa Ana, California in January, while not as cheap as those in September, still average around $158.

What is the cheapest day to depart on your flight to Santa Ana, California?

The cheapest day to depart from Des Moines to Santa Ana, California is on a Wednesday. Travelers who choose to depart for Santa Ana, California on a Wednesday will often find tickets for as low as $158. The most expensive day to fly to Santa Ana, California is Tuesday, with ticket prices averaging around $450.

What is the cheapest time of day to depart on your flight to Santa Ana, California?

In the afternoon is the cheapest time of day to fly from Des Moines to Santa Ana, California when you can find flight prices for as low as $163. Flying to Santa Ana, California in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Santa Ana, California is in the morning when prices are around $207.

What is the cheapest Des Moines to Santa Ana J. Wayne/Orange Cnty flight route?

Fly from Des Moines to Santa Ana J. Wayne/Orange Cnty for the best Des Moines - Santa Ana J. Wayne/Orange Cnty flight prices

How far in advance should I book a flight to Santa Ana, California?

You are more likely to see cheaper flights to Santa Ana, California from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $315 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from Des Moines for as low as $151 on momondo.

What cabin class options are available on Des Moines to Santa Ana J. Wayne/Orange Cnty flights?

There is only 1 cabin class available to choose from on Des Moines to Santa Ana J. Wayne/Orange Cnty flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Santa Ana, California flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Santa Ana, California.

How have Des Moines to Santa Ana, California flight prices changed over time?

As of April 2026, prices for Des Moines to Santa Ana, California flights are approximately 51% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Ana, California (DSM to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Ana, California

Best Price Found

$162

Fastest flight time

3h 33m

Direct flights

Mon, Tue, Fri and Sat

Airports in Santa Ana, California

1 airport
The best one-way flight to Santa Ana, California from Des Moines in the past 72 hours is $162. The best round-trip flight deal from Des Moines to Santa Ana, California found on momondo in the last 72 hours is $208.
The fastest flight from Des Moines to Santa Ana, California takes 3h 33m
Direct flights go from Des Moines to Santa Ana, California on Monday, Tuesday, Friday and Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Santa Ana, California. From Des Moines there are direct flights to Santa Ana J. Wayne/Orange Cnty (SNA).
Search flight deals

Frequently asked questions about flying from Des Moines to Santa Ana, California

  • How far is Des Moines to Santa Ana J. Wayne/Orange Cnty by plane?

    The straight-line distance from Des Moines to Santa Ana J. Wayne/Orange Cnty is 1425.0 mi. Flights usually cover this in 3h 33m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The travel and health documents you'll need for your trip to Santa Ana J. Wayne/Orange Cnty Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Santa Ana, California?

  • What is the most popular airline from Des Moines to Santa Ana, California?

Best airlines flying from Des Moines to Santa Ana, California

Compare and see reviews for airlines that fly from Des Moines to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $108Free CancellationRating
7.3
709 reviews
Search Allegiant Air flights
United AirlinesPriceFrom $253Free CancellationRating
7.4
9,530 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.1
11,543 reviews
Search American Airlines flights
SouthwestPriceFrom $340Free CancellationRating
8.0
4,335 reviews
Search Southwest flights

  • Southwest Flights From Des Moines to Santa Ana, California

    Across 3 Southwest flights from Des Moines to Santa Ana, California this week, the average price was $476, with the best Southwest deals starting from $340 round-trip. 4,334 users have rated Southwest on momondo, with an average score of 8.0/10.

Traveling to a place near Los Angeles?

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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Santa Ana for you.

Can I find flights from Des Moines to Santa Ana with flexible booking policies on momondo?

Yes. All flights to Santa Ana from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Santa Ana?

momondo helps you find the best flight between Des Moines and Santa Ana by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Santa Ana right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Santa Ana flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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