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Cheap flights from Des Moines to Los Angeles from $108

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Los Angeles departing on 1/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
7:00 am - 8:47 am
DSM
-
SNA
3h 47mnonstop
Allegiant Air Logo
9:37 am - 3:03 pm
SNA
-
DSM
3h 26mnonstop
$108Allegiant Air
Sun, Jan 25 - Thu, Jan 29
Allegiant Air Logo
7:00 am - 8:47 am
DSM
-
SNA
3h 47mnonstop
Allegiant Air Logo
9:37 am - 3:03 pm
SNA
-
DSM
3h 26mnonstop
$164Allegiant Air
Thu, Feb 5 - Sun, Feb 8
Allegiant Air Logo
7:00 am - 8:47 am
DSM
-
SNA
3h 47mnonstop
Allegiant Air Logo
9:37 am - 3:03 pm
SNA
-
DSM
3h 26mnonstop
$172Allegiant Air
Thu, Feb 5 - Sun, Feb 8
Allegiant Air Logo
7:15 am - 9:15 am
DSM
-
SNA
4h 00mnonstop
Allegiant Air Logo
10:05 am - 3:24 pm
SNA
-
DSM
3h 19mnonstop
$189Allegiant Air
Fri, Feb 20 - Mon, Feb 23
Multiple Airlines Logo
4:30 pm - 8:57 pm
DSM
-
SNA
30h 27m2 stops
Multiple Airlines Logo
9:37 am - 3:03 pm
SNA
-
DSM
3h 26mnonstop
$195Multiple Airlines
Sun, Jan 25 - Thu, Jan 29
Multiple Airlines Logo
7:00 am - 8:47 am
DSM
-
SNA
3h 47mnonstop
Multiple Airlines Logo
4:37 pm - 10:51 pm
SNA
-
DSM
28h 14m1 stop
$206Multiple Airlines
Thu, Feb 5 - Thu, Feb 12
Allegiant Air Logo
7:15 am - 9:15 am
DSM
-
SNA
4h 00mnonstop
Allegiant Air Logo
10:05 am - 3:24 pm
SNA
-
DSM
3h 19mnonstop
$207Allegiant Air
Fri, Feb 13 - Mon, Feb 16
Multiple Airlines Logo
8:30 am - 3:42 pm
DSM
-
SNA
9h 12m1 stop
Multiple Airlines Logo
6:45 am - 3:40 pm
SNA
-
DSM
6h 55m1 stop
$222Multiple Airlines
Mon, Feb 2 - Fri, Feb 6
Multiple Airlines Logo
4:30 pm - 8:57 pm
DSM
-
SNA
30h 27m2 stops
Multiple Airlines Logo
4:37 pm - 3:40 pm
SNA
-
DSM
21h 03m1 stop
$225Multiple Airlines
Sun, Jan 25 - Thu, Jan 29
Allegiant Air Logo
7:15 am - 9:15 am
DSM
-
SNA
4h 00mnonstop
Allegiant Air Logo
10:05 am - 3:24 pm
SNA
-
DSM
3h 19mnonstop
$228Allegiant Air
Fri, Feb 13 - Mon, Feb 16

Southwest flights from Des Moines to Santa Ana, California

Our best Southwest deals on Des Moines to Santa Ana, California flight tickets
Southwest
Jan 25
DSM6:25 amDes Moines
8h 45m
2 stops
SNA1:10 pmSanta Ana J. Wayne/Orange Cnty
Jan 29
SNA11:10 amSanta Ana J. Wayne/Orange Cnty
6h 10m
2 stops
DSM7:20 pmDes Moines
$394
Find similar
Southwest
Feb 2
DSM12:05 pmDes Moines
10h 00m
2 stops
SNA8:05 pmSanta Ana J. Wayne/Orange Cnty
Feb 6
SNA11:25 amSanta Ana J. Wayne/Orange Cnty
7h 55m
2 stops
DSM9:20 pmDes Moines
$404
Find similar
Southwest
Dec 29
DSM5:30 amDes Moines
10h 30m
2 stops
SNA2:00 pmSanta Ana J. Wayne/Orange Cnty
Jan 3
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
9h 15m
2 stops
DSM6:00 pmDes Moines
$937
Find similar

United Airlines flights from Des Moines to Santa Ana, California

Our best United Airlines deals on Des Moines to Santa Ana, California flight tickets
United Airlines
Feb 21
DSM5:30 amDes Moines
6h 15m
1 stop
SNA9:45 amSanta Ana J. Wayne/Orange Cnty
Feb 25
SNA11:10 amSanta Ana J. Wayne/Orange Cnty
8h 31m
2 stops
DSM9:41 pmDes Moines
$322
Find similar
United Airlines
Jan 1
DSM8:00 amDes Moines
11h 30m
2 stops
SNA5:30 pmSanta Ana J. Wayne/Orange Cnty
Jan 8
SNA8:00 amSanta Ana J. Wayne/Orange Cnty
11h 50m
2 stops
DSM9:50 pmDes Moines
$454
Find similar
United Airlines
Jan 22
DSM1:35 pmDes Moines
9h 07m
2 stops
SNA8:42 pmSanta Ana J. Wayne/Orange Cnty
Jan 26
SNA6:25 pmSanta Ana J. Wayne/Orange Cnty
14h 30m
2 stops
DSM10:55 amDes Moines
$467
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Ana, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 25, 2025.
Use the filters below to find and compare flights from Des Moines to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sun 1/25

7:00 am-8:47 am

Nonstop3h 47m

Santa Ana J. Wayne/Orange Cnty

Thu 1/29

9:37 am-3:03 pm

Nonstop3h 26m

$108

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 2/5

7:00 am-8:47 am

Nonstop3h 47m

Santa Ana J. Wayne/Orange Cnty

Sun 2/8

9:37 am-3:03 pm

Nonstop3h 26m

$164

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 2/5

7:00 am-8:47 am

Nonstop3h 47m

Santa Ana J. Wayne/Orange Cnty

Sun 2/8

9:37 am-3:03 pm

Nonstop3h 26m

$172

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Fri 2/20

7:15 am-9:15 am

Nonstop4h 00m

Santa Ana J. Wayne/Orange Cnty

Mon 2/23

10:05 am-3:24 pm

Nonstop3h 19m

$189

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sun 1/25

4:30 pm-8:57 pm

2 stops30h 27m

Santa Ana J. Wayne/Orange Cnty

Thu 1/29

9:37 am-3:03 pm

Nonstop3h 26m

$195

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 2/5

7:00 am-8:47 am

Nonstop3h 47m

Santa Ana J. Wayne/Orange Cnty

Thu 2/12

4:37 pm-10:51 pm

1 stop28h 14m

$206

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Fri 2/13

7:15 am-9:15 am

Nonstop4h 00m

Santa Ana J. Wayne/Orange Cnty

Mon 2/16

10:05 am-3:24 pm

Nonstop3h 19m

$207

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 2/2

8:30 am-3:42 pm

1 stop9h 12m

Santa Ana J. Wayne/Orange Cnty

Fri 2/6

6:45 am-3:40 pm

1 stop6h 55m

$222

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sun 1/25

4:30 pm-8:57 pm

2 stops30h 27m

Santa Ana J. Wayne/Orange Cnty

Thu 1/29

4:37 pm-3:40 pm

1 stop21h 03m

$225

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Fri 2/13

7:15 am-9:15 am

Nonstop4h 00m

Santa Ana J. Wayne/Orange Cnty

Mon 2/16

10:05 am-3:24 pm

Nonstop3h 19m

$228

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santa Ana, California?

In general, September is the cheapest month to fly from Des Moines to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $131. If you aren’t able to travel during the month of September, then book flights to Santa Ana, California from Des Moines during January instead. Flights to Santa Ana, California in January, while not as cheap as those in September, still average around $193.

What is the cheapest day to depart on your flight to Santa Ana, California?

The cheapest day to depart from Des Moines to Santa Ana, California is on a Sunday. Travelers who choose to depart for Santa Ana, California on a Sunday will often find tickets for as low as $139. The most expensive day to fly to Santa Ana, California is Tuesday, with ticket prices averaging around $395.

What is the cheapest time of day to depart on your flight to Santa Ana, California?

In the afternoon is the cheapest time of day to fly from Des Moines to Santa Ana, California when you can find flight prices for as low as $135. Flying to Santa Ana, California in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Santa Ana, California is in the morning when prices are around $201.

What is the cheapest Des Moines to Santa Ana J. Wayne/Orange Cnty flight route?

Fly from Des Moines to Santa Ana J. Wayne/Orange Cnty for the best Des Moines - Santa Ana J. Wayne/Orange Cnty flight prices

How far in advance should I book a flight to Santa Ana, California?

You are more likely to see cheaper flights to Santa Ana, California from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $312 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from Des Moines for as low as $134 on momondo.

What cabin class options are available on Des Moines to Santa Ana J. Wayne/Orange Cnty flights?

There is only 1 cabin class available to choose from on Des Moines to Santa Ana J. Wayne/Orange Cnty flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Santa Ana, California flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Santa Ana, California.

How have Des Moines to Santa Ana, California flight prices changed over time?

As of December 2025, prices for Des Moines to Santa Ana, California flights are approximately 68% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Ana, California (DSM to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Ana, California

Best Price Found

$142

Fastest flight time

3h 46m

Direct flights

Mon, Fri and Sat

Airports in Santa Ana, California

1 airport
The best flight deal from Des Moines to Santa Ana, California found on momondo in the last 72 hours is $142
The fastest flight from Des Moines to Santa Ana, California takes 3h 46m
Direct flights go from Des Moines to Santa Ana, California on Monday, Friday and Saturday. There are no airlines offering direct flights.
There is 1 airport in Santa Ana, California. From Des Moines there are direct flights to Santa Ana J. Wayne/Orange Cnty (SNA).
Search flight deals

  • How far is Des Moines to Santa Ana J. Wayne/Orange Cnty by plane?

    The straight-line distance from Des Moines to Santa Ana J. Wayne/Orange Cnty is 1425.0 mi. Flights usually cover this in 3h 46m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The travel and health documents you'll need for your trip to Santa Ana J. Wayne/Orange Cnty Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Santa Ana, California?

  • What is the most popular airline from Des Moines to Santa Ana, California?

Best airlines flying from Des Moines to Santa Ana, California

Compare and see reviews for airlines that fly from Des Moines to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $108Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
United AirlinesPriceFrom $260Free CancellationRating
7.4
9,115 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
11,061 reviews
Search American Airlines flights
SouthwestPriceFrom $340Free CancellationRating
8.0
4,258 reviews
Search Southwest flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Santa Ana for you.

Can I find flights from Des Moines to Santa Ana with flexible booking policies on momondo?

Yes. All flights to Santa Ana from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Santa Ana?

momondo helps you find the best flight between Des Moines and Santa Ana by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Santa Ana right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Santa Ana flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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