Cheap flights from Des Moines to Los Angeles from $91

The cheapest month to fly to Santa Ana from Des Moines is in September. Flight prices, which tend to average around $131, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Santa Ana, with average flight prices from Des Moines averaging around $158.

On average, the least expensive day to fly to Santa Ana from Des Moines is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $136. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Tuesday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $395.

Our data shows that the cheapest Des Moines to Santa Ana flights are usually those with departure times in the afternoon. Our users have found flights to Santa Ana in the afternoon for as low as $139. Try not to purchase tickets in the morning because they tend to be around $190. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Des Moines to Santa Ana J. Wayne/Orange Cnty for the best Des Moines - Santa Ana J. Wayne/Orange Cnty flight prices

You are more likely to see cheaper flights to Santa Ana from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana for around $309 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana from Des Moines for as low as $151 on momondo.

There is only 1 cabin class available to choose from on Des Moines to Santa Ana J. Wayne/Orange Cnty flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Des Moines to Santa Ana.

As of February 2026, prices for Des Moines to Santa Ana flights are approximately 217% more expensive when compared to flights at the same time last year.

Allegiant Air, United Airlines, and American Airlines are the most popular carriers operating from Des Moines to Santa Ana J. Wayne/Orange Cnty

American Airlines, United Airlines and Southwest are the top three most popular airlines that fly to Santa Ana from Des Moines according to our data. American Airlines is the first choice among our users, with 42% of people opting to fly with this airline when traveling to Santa Ana. Keep in mind that there are 6 different airlines that fly to Santa Ana on a routine basis, so you have a few additional options to choose from.