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Cheap flights from Des Moines to Los Angeles from $65

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Los Angeles departing on 5/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
10:00 am - 11:51 am
DSM
-
SNA
3h 51mnonstop
Allegiant Air Logo
10:32 am - 3:51 pm
SNA
-
DSM
3h 19mnonstop
$138Allegiant Air
Mon, May 11 - Thu, May 21
Allegiant Air Logo
7:00 am - 8:33 am
DSM
-
SNA
3h 33mnonstop
Allegiant Air Logo
9:32 am - 2:51 pm
SNA
-
DSM
3h 19mnonstop
$199Allegiant Air
Thu, Jul 30 - Thu, Aug 6
Multiple Airlines Logo
10:00 am - 11:51 am
DSM
-
SNA
3h 51mnonstop
Multiple Airlines Logo
4:33 pm - 8:52 pm
SNA
-
DSM
26h 19m
1 stop
$205Multiple Airlines
Mon, May 11 - Thu, May 21
Multiple Airlines Logo
9:45 am - 11:36 am
DSM
-
SNA
3h 51mnonstop
Multiple Airlines Logo
8:14 pm - 9:11 pm
SNA
-
DSM
22h 57m
1 stop
$209Multiple Airlines
Fri, May 1 - Thu, May 7
Allegiant Air Logo
7:00 am - 8:38 am
DSM
-
SNA
3h 38mnonstop
Allegiant Air Logo
9:28 am - 2:42 pm
SNA
-
DSM
3h 14mnonstop
$215Allegiant Air
Thu, Jun 4 - Thu, Jun 18
Multiple Airlines Logo
2:16 pm - 9:09 am
DSM
-
SNA
20h 53m
1 stop
Multiple Airlines Logo
9:28 am - 2:42 pm
SNA
-
DSM
3h 14mnonstop
$216Multiple Airlines
Wed, Jun 3 - Thu, Jun 18
Multiple Airlines Logo
2:16 pm - 3:23 pm
DSM
-
SNA
27h 07m
2 stops
Multiple Airlines Logo
10:32 am - 3:51 pm
SNA
-
DSM
3h 19mnonstop
$218Multiple Airlines
Mon, May 11 - Thu, May 21
Allegiant Air Logo
7:00 am - 8:38 am
DSM
-
SNA
3h 38mnonstop
Allegiant Air Logo
9:28 am - 2:42 pm
SNA
-
DSM
3h 14mnonstop
$220Allegiant Air
Sun, Jun 21 - Thu, Jun 25
Allegiant Air Logo
7:00 am - 8:33 am
DSM
-
SNA
3h 33mnonstop
Allegiant Air Logo
9:32 am - 2:51 pm
SNA
-
DSM
3h 19mnonstop
$222Allegiant Air
Thu, Jul 30 - Thu, Aug 6
Multiple Airlines Logo
2:16 pm - 9:09 am
DSM
-
SNA
20h 53m
1 stop
Multiple Airlines Logo
9:28 am - 2:42 pm
SNA
-
DSM
3h 14mnonstop
$230Multiple Airlines
Wed, Jun 3 - Thu, Jun 18

Allegiant Air flights from Des Moines to Santa Ana

Our best Allegiant Air deals on Des Moines to Santa Ana flight tickets
Allegiant Air
May 11
DSM10:00 amDes Moines
3h 51m
SNA11:51 amSanta Ana J. Wayne/Orange Cnty
May 21
SNA10:32 amSanta Ana J. Wayne/Orange Cnty
3h 19m
DSM3:51 pmDes Moines
$138
Allegiant Air
Apr 20
DSM10:00 amDes Moines
3h 51m
SNA11:51 amSanta Ana J. Wayne/Orange Cnty
Apr 24
SNA12:26 pmSanta Ana J. Wayne/Orange Cnty
3h 17m
DSM5:43 pmDes Moines
$188
Allegiant Air
Jul 30
DSM7:00 amDes Moines
3h 33m
SNA8:33 amSanta Ana J. Wayne/Orange Cnty
Aug 6
SNA9:32 amSanta Ana J. Wayne/Orange Cnty
3h 19m
DSM2:51 pmDes Moines
$199

Southwest flights from Des Moines to Santa Ana

Our best Southwest deals on Des Moines to Santa Ana flight tickets
Southwest
Jun 6
DSM6:10 amDes Moines
5h 15m
1 stop
SNA9:25 amSanta Ana J. Wayne/Orange Cnty
Jun 9
SNA11:05 amSanta Ana J. Wayne/Orange Cnty
5h 15m
1 stop
DSM6:20 pmDes Moines
$285
Southwest
Apr 28
DSM6:55 amDes Moines
5h 30m
1 stop
SNA10:25 amSanta Ana J. Wayne/Orange Cnty
May 1
SNA12:30 pmSanta Ana J. Wayne/Orange Cnty
7h 25m
2 stops
DSM9:55 pmDes Moines
$572

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 15, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Ana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 5/11

10:00 am-11:51 am

Nonstop3h 51m

Santa Ana J. Wayne/Orange Cnty

Thu 5/21

10:32 am-3:51 pm

Nonstop3h 19m

$138
Quickest round-trip

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 7/30

7:00 am-8:33 am

Nonstop3h 33m

Santa Ana J. Wayne/Orange Cnty

Thu 8/6

9:32 am-2:51 pm

Nonstop3h 19m

$199

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 5/11

10:00 am-11:51 am

Nonstop3h 51m

Santa Ana J. Wayne/Orange Cnty

Thu 5/21

4:33 pm-8:52 pm

1 stop26h 19m

$205

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Fri 5/1

9:45 am-11:36 am

Nonstop3h 51m

Santa Ana J. Wayne/Orange Cnty

Thu 5/7

8:14 pm-9:11 pm

1 stop22h 57m

$209

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 6/4

7:00 am-8:38 am

Nonstop3h 38m

Santa Ana J. Wayne/Orange Cnty

Thu 6/18

9:28 am-2:42 pm

Nonstop3h 14m

$215

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Wed 6/3

2:16 pm-9:09 am

1 stop20h 53m

Santa Ana J. Wayne/Orange Cnty

Thu 6/18

9:28 am-2:42 pm

Nonstop3h 14m

$216

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 5/11

2:16 pm-3:23 pm

2 stops27h 07m

Santa Ana J. Wayne/Orange Cnty

Thu 5/21

10:32 am-3:51 pm

Nonstop3h 19m

$218

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sun 6/21

7:00 am-8:38 am

Nonstop3h 38m

Santa Ana J. Wayne/Orange Cnty

Thu 6/25

9:28 am-2:42 pm

Nonstop3h 14m

$220

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 7/30

7:00 am-8:33 am

Nonstop3h 33m

Santa Ana J. Wayne/Orange Cnty

Thu 8/6

9:32 am-2:51 pm

Nonstop3h 19m

$222

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Wed 6/3

2:16 pm-9:09 am

1 stop20h 53m

Santa Ana J. Wayne/Orange Cnty

Thu 6/18

9:28 am-2:42 pm

Nonstop3h 14m

$230

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Santa Ana

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Santa Ana?

What is the cheapest month to fly to Santa Ana?

The cheapest month to fly to Santa Ana from Des Moines is in September. Flight prices, which tend to average around $138, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Santa Ana, with average flight prices from Des Moines averaging around $158.

What is the cheapest day to depart on your flight to Santa Ana?

On average, the least expensive day to fly to Santa Ana from Des Moines is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $158. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Tuesday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $450.

What is the cheapest time of day to depart on your flight to Santa Ana?

Our data shows that the cheapest Des Moines to Santa Ana flights are usually those with departure times in the afternoon. Our users have found flights to Santa Ana in the afternoon for as low as $163. Try not to purchase tickets in the morning because they tend to be around $211. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Des Moines to Santa Ana J. Wayne/Orange Cnty flight route?

Fly from Des Moines to Santa Ana J. Wayne/Orange Cnty for the best Des Moines - Santa Ana J. Wayne/Orange Cnty flight prices

How far in advance should I book a flight to Santa Ana?

You are more likely to see cheaper flights to Santa Ana from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana for around $315 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana from Des Moines for as low as $165 on momondo.

What cabin class options are available on Des Moines to Santa Ana J. Wayne/Orange Cnty flights?

There is only 1 cabin class available to choose from on Des Moines to Santa Ana J. Wayne/Orange Cnty flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Santa Ana flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Santa Ana.

How have Des Moines to Santa Ana flight prices changed over time?

As of April 2026, prices for Des Moines to Santa Ana flights are approximately 139% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Santa Ana

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Ana according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Ana (DSM to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Ana

Best Price Found

$176

Fastest flight time

3h 33m

Direct flights

Mon, Tue, Fri and Sat

Airports in Santa Ana

1 airport
The best one-way flight to Santa Ana from Des Moines in the past 72 hours is $176. The best round-trip flight deal from Des Moines to Santa Ana found on momondo in the last 72 hours is $190.
The fastest flight from Des Moines to Santa Ana takes 3h 33m
Direct flights go from Des Moines to Santa Ana on Monday, Tuesday, Friday and Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Santa Ana. From Des Moines there are direct flights to Santa Ana J. Wayne/Orange Cnty (SNA).
Search flight deals

Frequently asked questions about flying from Des Moines to Santa Ana

  • How far is Des Moines to Santa Ana J. Wayne/Orange Cnty by plane?

    The straight-line distance from Des Moines to Santa Ana J. Wayne/Orange Cnty is 1425.0 mi. Flights usually cover this in 3h 33m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The travel and health documents you'll need for your trip to Santa Ana J. Wayne/Orange Cnty Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Santa Ana?

  • What is the most popular airline from Des Moines to Santa Ana?

Best airlines flying from Des Moines to Santa Ana

Compare and see reviews for airlines that fly from Des Moines to Santa Ana with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $108Free CancellationRating
7.3
707 reviews
Search Allegiant Air flights
United AirlinesPriceFrom $268Free CancellationRating
7.4
9,586 reviews
Search United Airlines flights
American AirlinesPriceFrom $300Free CancellationRating
7.1
11,580 reviews
Search American Airlines flights
SouthwestPriceFrom $340Free CancellationRating
8.0
4,328 reviews
Search Southwest flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Santa Ana for you.

Can I find flights from Des Moines to Santa Ana with flexible booking policies on momondo?

Yes. All flights to Santa Ana from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Santa Ana?

momondo helps you find the best flight between Des Moines and Santa Ana by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Santa Ana right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Santa Ana flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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