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Cheap flights from Des Moines to Los Angeles from $114

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Los Angeles departing on 2/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
7:15 am - 9:15 am
DSM
-
SNA
4h 00mnonstop
Allegiant Air Logo
10:05 am - 3:24 pm
SNA
-
DSM
3h 19mnonstop
$114Allegiant Air
Mon, Feb 16 - Fri, Feb 20
Allegiant Air Logo
7:15 am - 9:15 am
DSM
-
SNA
4h 00mnonstop
Allegiant Air Logo
10:05 am - 3:24 pm
SNA
-
DSM
3h 19mnonstop
$120Allegiant Air
Mon, Feb 16 - Fri, Feb 20
Allegiant Air Logo
7:00 am - 8:47 am
DSM
-
SNA
3h 47mnonstop
Allegiant Air Logo
9:37 am - 3:03 pm
SNA
-
DSM
3h 26mnonstop
$157Allegiant Air
Sun, Jan 25 - Thu, Feb 5
Allegiant Air Logo
7:15 am - 9:13 am
DSM
-
SNA
3h 58mnonstop
Allegiant Air Logo
9:45 am - 3:01 pm
SNA
-
DSM
3h 16mnonstop
$174Allegiant Air
Mon, Mar 2 - Mon, Mar 9
Allegiant Air Logo
7:15 am - 9:13 am
DSM
-
SNA
3h 58mnonstop
Allegiant Air Logo
9:45 am - 3:01 pm
SNA
-
DSM
3h 16mnonstop
$185Allegiant Air
Mon, Mar 2 - Mon, Mar 9
Allegiant Air Logo
7:15 am - 9:15 am
DSM
-
SNA
4h 00mnonstop
Allegiant Air Logo
10:05 am - 3:24 pm
SNA
-
DSM
3h 19mnonstop
$188Allegiant Air
Mon, Feb 16 - Mon, Feb 23
Multiple Airlines Logo
7:17 pm - 3:42 pm
DSM
-
SNA
22h 25m
2 stops
Multiple Airlines Logo
10:05 am - 3:24 pm
SNA
-
DSM
3h 19mnonstop
$196Multiple Airlines
Mon, Feb 16 - Fri, Feb 20
Multiple Airlines Logo
7:17 pm - 8:57 pm
DSM
-
SNA
27h 40m
3 stops
Multiple Airlines Logo
10:05 am - 3:24 pm
SNA
-
DSM
3h 19mnonstop
$199Multiple Airlines
Mon, Feb 16 - Fri, Feb 20
Multiple Airlines Logo
7:17 pm - 3:42 pm
DSM
-
SNA
22h 25m
2 stops
Multiple Airlines Logo
10:05 am - 3:24 pm
SNA
-
DSM
3h 19mnonstop
$201Multiple Airlines
Mon, Feb 16 - Fri, Feb 20
Multiple Airlines Logo
3:39 pm - 3:42 pm
DSM
-
SNA
26h 03m
1 stop
Multiple Airlines Logo
10:05 am - 3:24 pm
SNA
-
DSM
3h 19mnonstop
$202Multiple Airlines
Mon, Feb 16 - Fri, Feb 20

Frontier flights from Des Moines to Santa Ana, California

Our best Frontier deals on Des Moines to Santa Ana, California flight tickets
Frontier
Feb 26
DSM7:27 pmDes Moines
17h 19m
1 stop
SNA10:46 amSanta Ana J. Wayne/Orange Cnty
Feb 28
SNA7:25 pmSanta Ana J. Wayne/Orange Cnty
21h 17m
2 stops
DSM6:42 pmDes Moines
$302
Frontier
Feb 26
DSM7:27 pmDes Moines
17h 19m
1 stop
SNA10:46 amSanta Ana J. Wayne/Orange Cnty
Feb 28
SNA12:25 pmSanta Ana J. Wayne/Orange Cnty
28h 17m
1 stop
DSM6:42 pmDes Moines
$309

Allegiant Air flights from Des Moines to Santa Ana, California

Our best Allegiant Air deals on Des Moines to Santa Ana, California flight tickets
Allegiant Air
Feb 16
DSM7:15 amDes Moines
4h 00m
SNA9:15 amSanta Ana J. Wayne/Orange Cnty
Feb 20
SNA10:05 amSanta Ana J. Wayne/Orange Cnty
3h 19m
DSM3:24 pmDes Moines
$114
Allegiant Air
Feb 16
DSM7:15 amDes Moines
4h 00m
SNA9:15 amSanta Ana J. Wayne/Orange Cnty
Feb 20
SNA10:05 amSanta Ana J. Wayne/Orange Cnty
3h 19m
DSM3:24 pmDes Moines
$120
Allegiant Air
Jan 25
DSM7:00 amDes Moines
3h 47m
SNA8:47 amSanta Ana J. Wayne/Orange Cnty
Feb 5
SNA9:37 amSanta Ana J. Wayne/Orange Cnty
3h 26m
DSM3:03 pmDes Moines
$157

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Ana, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 17, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 2/16

7:15 am-9:15 am

Nonstop4h 00m

Santa Ana J. Wayne/Orange Cnty

Fri 2/20

10:05 am-3:24 pm

Nonstop3h 19m

$114

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 2/16

7:15 am-9:15 am

Nonstop4h 00m

Santa Ana J. Wayne/Orange Cnty

Fri 2/20

10:05 am-3:24 pm

Nonstop3h 19m

$120

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sun 1/25

7:00 am-8:47 am

Nonstop3h 47m

Santa Ana J. Wayne/Orange Cnty

Thu 2/5

9:37 am-3:03 pm

Nonstop3h 26m

$157

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 3/2

7:15 am-9:13 am

Nonstop3h 58m

Santa Ana J. Wayne/Orange Cnty

Mon 3/9

9:45 am-3:01 pm

Nonstop3h 16m

$174

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 3/2

7:15 am-9:13 am

Nonstop3h 58m

Santa Ana J. Wayne/Orange Cnty

Mon 3/9

9:45 am-3:01 pm

Nonstop3h 16m

$185

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 2/16

7:15 am-9:15 am

Nonstop4h 00m

Santa Ana J. Wayne/Orange Cnty

Mon 2/23

10:05 am-3:24 pm

Nonstop3h 19m

$188

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 2/16

7:17 pm-3:42 pm

2 stops22h 25m

Santa Ana J. Wayne/Orange Cnty

Fri 2/20

10:05 am-3:24 pm

Nonstop3h 19m

$196

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 2/16

7:17 pm-8:57 pm

3 stops27h 40m

Santa Ana J. Wayne/Orange Cnty

Fri 2/20

10:05 am-3:24 pm

Nonstop3h 19m

$199

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 2/16

7:17 pm-3:42 pm

2 stops22h 25m

Santa Ana J. Wayne/Orange Cnty

Fri 2/20

10:05 am-3:24 pm

Nonstop3h 19m

$201

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 2/16

3:39 pm-3:42 pm

1 stop26h 03m

Santa Ana J. Wayne/Orange Cnty

Fri 2/20

10:05 am-3:24 pm

Nonstop3h 19m

$202

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Los Angeles from

How to get the cheapest flight ticket from Des Moines to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santa Ana, California?

In general, September is the cheapest month to fly from Des Moines to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $131. If you aren’t able to travel during the month of September, then book flights to Santa Ana, California from Des Moines during January instead. Flights to Santa Ana, California in January, while not as cheap as those in September, still average around $178.

What is the cheapest day to depart on your flight to Santa Ana, California?

The cheapest day to depart from Des Moines to Santa Ana, California is on a Saturday. Travelers who choose to depart for Santa Ana, California on a Saturday will often find tickets for as low as $144. The most expensive day to fly to Santa Ana, California is Tuesday, with ticket prices averaging around $395.

What is the cheapest time of day to depart on your flight to Santa Ana, California?

In the afternoon is the cheapest time of day to fly from Des Moines to Santa Ana, California when you can find flight prices for as low as $135. Flying to Santa Ana, California in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Santa Ana, California is in the morning when prices are around $191.

What is the cheapest Des Moines to Santa Ana J. Wayne/Orange Cnty flight route?

Fly from Des Moines to Santa Ana J. Wayne/Orange Cnty for the best Des Moines - Santa Ana J. Wayne/Orange Cnty flight prices

How far in advance should I book a flight to Santa Ana, California?

You are more likely to see cheaper flights to Santa Ana, California from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $314 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from Des Moines for as low as $134 on momondo.

What cabin class options are available on Des Moines to Santa Ana J. Wayne/Orange Cnty flights?

There is only 1 cabin class available to choose from on Des Moines to Santa Ana J. Wayne/Orange Cnty flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Santa Ana, California flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Santa Ana, California.

How have Des Moines to Santa Ana, California flight prices changed over time?

As of January 2026, prices for Des Moines to Santa Ana, California flights are approximately 65% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Ana, California (DSM to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Ana, California

Best Price Found

$255

Fastest flight time

3h 55m

Direct flights

Tue, Fri and Sat

Airports in Santa Ana, California

1 airport
The best one-way flight to Santa Ana, California from Des Moines in the past 72 hours is $255. The best round-trip flight deal from Des Moines to Santa Ana, California found on momondo in the last 72 hours is $134.
The fastest flight from Des Moines to Santa Ana, California takes 3h 55m
Direct flights go from Des Moines to Santa Ana, California on Tuesday, Friday and Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Santa Ana, California. From Des Moines there are direct flights to Santa Ana J. Wayne/Orange Cnty (SNA).
Search flight deals

  • How far is Des Moines to Santa Ana J. Wayne/Orange Cnty by plane?

    The straight-line distance from Des Moines to Santa Ana J. Wayne/Orange Cnty is 1425.0 mi. Flights usually cover this in 3h 55m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The travel and health documents you'll need for your trip to Santa Ana J. Wayne/Orange Cnty Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Santa Ana, California?

  • What is the most popular airline from Des Moines to Santa Ana, California?

Best airlines flying from Des Moines to Santa Ana, California

Compare and see reviews for airlines that fly from Des Moines to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $108Free CancellationRating
7.2
704 reviews
Search Allegiant Air flights
United AirlinesPriceFrom $243Free CancellationRating
7.4
9,174 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
11,155 reviews
Search American Airlines flights
SouthwestPriceFrom $340Free CancellationRating
8.0
4,261 reviews
Search Southwest flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Santa Ana for you.

Can I find flights from Des Moines to Santa Ana with flexible booking policies on momondo?

Yes. All flights to Santa Ana from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Santa Ana?

momondo helps you find the best flight between Des Moines and Santa Ana by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Santa Ana right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Santa Ana flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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