Cheap flights from Massachusetts to San Diego from $132

If you are unable to visit San Diego during the month of January, then departing from Massachusetts during the month May is also very affordable. Most momondo users find prices during this month for around $343.

The cheapest day to depart from Massachusetts to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $350. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $465. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $381. Flights at noon are often more expensive with an average ticket price of $390.

Fly from Boston Logan Intl to San Diego for the best Massachusetts - San Diego flight prices

You are more likely to see cheaper flights to San Diego from Massachusetts when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $381 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Massachusetts for as low as $342 on momondo.

There are 4 cabin classes available to choose from on Massachusetts to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest and Alaska Airlines are the most popular carriers operating from Massachusetts to San Diego

JetBlue, American Airlines and Delta are the top three most popular airlines that fly to San Diego from Massachusetts according to our data. JetBlue is the first choice among our users, with 46% of people opting to fly with this airline when traveling to San Diego. Keep in mind that there are 7 different airlines that fly to San Diego on a routine basis, so you have a few additional options to choose from.

The number of flights available between Massachusetts and San Diego is 6 per day as of October 2026. The most frequent departure time is 7:00AM, with 44% of daily flights leaving at noon.

The number of flights available between Massachusetts and San Diego is 45 per week as of October 2026. The most frequent departure day is Wed, with 29% of weekly flights leaving on this day.