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Cheap flights from Des Moines to San Antonio from $99

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 3/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:17 pm - 1:45 pm
DSM
-
SAT
18h 28m
1 stop
Frontier Logo
8:53 pm - 10:05 am
SAT
-
DSM
13h 12m
1 stop
$184Frontier
Mon, Mar 2 - Mon, Mar 9
Frontier Logo
7:27 pm - 9:06 am
DSM
-
SAT
13h 39m
1 stop
Frontier Logo
10:05 am - 7:16 pm
SAT
-
DSM
9h 11m
1 stop
$208Frontier
Thu, Mar 5 - Mon, Mar 16
Frontier Logo
7:45 pm - 7:37 pm
DSM
-
SAT
23h 52m
1 stop
Frontier Logo
6:12 pm - 6:42 pm
SAT
-
DSM
24h 30m
1 stop
$230Frontier
Sun, Feb 22 - Wed, Feb 25
Multiple Airlines Logo
1:23 pm - 9:27 am
DSM
-
SAT
20h 04m
1 stop
Multiple Airlines Logo
10:05 am - 7:16 pm
SAT
-
DSM
9h 11m
1 stop
$241Multiple Airlines
Tue, Mar 24 - Fri, Mar 27
Frontier Logo
8:21 pm - 8:06 am
DSM
-
SAT
11h 45m
1 stop
Frontier Logo
10:05 am - 7:16 pm
SAT
-
DSM
9h 11m
1 stop
$259Frontier
Sat, Mar 7 - Sat, Mar 14
Multiple Airlines Logo
7:00 am - 9:30 am
DSM
-
SAT
50h 30m
2 stops
Multiple Airlines Logo
10:05 am - 7:16 pm
SAT
-
DSM
9h 11m
1 stop
$261Multiple Airlines
Sun, Mar 8 - Fri, Mar 13
Frontier Logo
7:45 pm - 7:37 pm
DSM
-
SAT
23h 52m
1 stop
Frontier Logo
8:20 pm - 7:04 pm
SAT
-
DSM
22h 44m
1 stop
$277Frontier
Sun, Feb 22 - Thu, Feb 26
Multiple Airlines Logo
3:32 pm - 4:18 pm
DSM
-
SAT
24h 46m
2 stops
Multiple Airlines Logo
6:12 pm - 6:42 pm
SAT
-
DSM
24h 30m
1 stop
$284Multiple Airlines
Sun, Feb 22 - Wed, Feb 25
Multiple Airlines Logo
8:29 pm - 9:30 am
DSM
-
SAT
37h 01m
2 stops
Multiple Airlines Logo
6:45 am - 7:16 pm
SAT
-
DSM
12h 31m
1 stop
$291Multiple Airlines
Mon, Mar 2 - Mon, Mar 9
Frontier Logo
8:21 pm - 9:06 am
DSM
-
SAT
12h 45m
1 stop
Frontier Logo
10:05 am - 7:16 pm
SAT
-
DSM
9h 11m
1 stop
$298Frontier
Wed, Mar 11 - Mon, Mar 16

Frontier flights from Des Moines to San Antonio

Our best Frontier deals on Des Moines to San Antonio flight tickets
Frontier
Mar 2
DSM7:17 pmDes Moines
18h 28m
1 stop
SAT1:45 pmSan Antonio
Mar 9
SAT8:53 pmSan Antonio
13h 12m
1 stop
DSM10:05 amDes Moines
$184
Frontier
Mar 9
DSM8:21 pmDes Moines
27h 56m
1 stop
SAT12:17 amSan Antonio
Mar 13
SAT10:05 amSan Antonio
9h 11m
1 stop
DSM7:16 pmDes Moines
$189
Frontier
Mar 9
DSM8:21 pmDes Moines
27h 56m
1 stop
SAT12:17 amSan Antonio
Mar 16
SAT10:05 amSan Antonio
9h 11m
1 stop
DSM7:16 pmDes Moines
$200

United Airlines flights from Des Moines to San Antonio

Our best United Airlines deals on Des Moines to San Antonio flight tickets
United Airlines
Mar 3
DSM2:59 pmDes Moines
6h 16m
1 stop
SAT9:15 pmSan Antonio
Mar 7
SAT5:50 pmSan Antonio
4h 54m
1 stop
DSM10:44 pmDes Moines
$352
United Airlines
Apr 7
DSM8:04 amDes Moines
9h 39m
2 stops
SAT5:43 pmSan Antonio
Apr 10
SAT6:02 pmSan Antonio
4h 41m
1 stop
DSM10:43 pmDes Moines
$358
United Airlines
Feb 12
DSM9:04 amDes Moines
10h 49m
2 stops
SAT7:53 pmSan Antonio
Feb 19
SAT5:20 amSan Antonio
9h 07m
2 stops
DSM2:27 pmDes Moines
$628

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Mon 3/2

7:17 pm-1:45 pm

1 stop18h 28m

San Antonio

Mon 3/9

8:53 pm-10:05 am

1 stop13h 12m

$184

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 3/5

7:27 pm-9:06 am

1 stop13h 39m

San Antonio

Mon 3/16

10:05 am-7:16 pm

1 stop9h 11m

$208

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sun 2/22

7:45 pm-7:37 pm

1 stop23h 52m

San Antonio

Wed 2/25

6:12 pm-6:42 pm

1 stop24h 30m

$230

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Tue 3/24

1:23 pm-9:27 am

1 stop20h 04m

San Antonio

Fri 3/27

10:05 am-7:16 pm

1 stop9h 11m

$241

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sat 3/7

8:21 pm-8:06 am

1 stop11h 45m

San Antonio

Sat 3/14

10:05 am-7:16 pm

1 stop9h 11m

$259

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sun 3/8

7:00 am-9:30 am

2 stops50h 30m

San Antonio

Fri 3/13

10:05 am-7:16 pm

1 stop9h 11m

$261

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sun 2/22

7:45 pm-7:37 pm

1 stop23h 52m

San Antonio

Thu 2/26

8:20 pm-7:04 pm

1 stop22h 44m

$277

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sun 2/22

3:32 pm-4:18 pm

2 stops24h 46m

San Antonio

Wed 2/25

6:12 pm-6:42 pm

1 stop24h 30m

$284

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Mon 3/2

8:29 pm-9:30 am

2 stops37h 01m

San Antonio

Mon 3/9

6:45 am-7:16 pm

1 stop12h 31m

$291

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 3/11

8:21 pm-9:06 am

1 stop12h 45m

San Antonio

Mon 3/16

10:05 am-7:16 pm

1 stop9h 11m

$298

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of August, then book flights to San Antonio from Des Moines during July instead. Flights to San Antonio in July, while not as cheap as those in August, still average around $334.

How far in advance should I book a flight to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $402 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $314 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of February 2026, prices for Des Moines to San Antonio flights are approximately 38% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Fastest flight time

5h 07m

Direct flights

None
The fastest flight from Des Moines to San Antonio takes 5h 07m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 5h 07m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $238Free CancellationRating
7.9
8,151 reviews
Search Delta flights
American AirlinesPriceFrom $270Free CancellationRating
7.2
11,237 reviews
Search American Airlines flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
9,240 reviews
Search United Airlines flights
SouthwestPriceFrom $316Free CancellationRating
8.0
4,275 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Pleasanton
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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