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Cheap flights from Des Moines to San Antonio from $113

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:25 pm - 7:26 pmDSM  Des Moines-SAT San Antonio
23h 01m1 stop Denver Intl
Frontier Logo
8:21 pm - 7:30 pmSAT  San Antonio-DSM Des Moines
23h 09m1 stop Denver Intl
$257Frontier
Fri, Oct 16 - Sun, Oct 18
Frontier Logo
2:51 pm - 10:12 amDSM  Des Moines-SAT San Antonio
19h 21m1 stop Denver Intl
Frontier Logo
11:08 am - 1:56 pmSAT  San Antonio-DSM Des Moines
26h 48m1 stop Denver Intl
$257Frontier
Fri, Nov 13 - Sun, Nov 15
American Airlines Logo
5:56 pm - 11:55 pmDSM  Des Moines-SAT San Antonio
5h 59m1 stop Chicago O'Hare Intl
American Airlines Logo
4:28 pm - 11:07 pmSAT  San Antonio-DSM Des Moines
6h 39m1 stop Dallas/Fort Worth
$325American Airlines
Thu, Oct 1 - Mon, Oct 5
American Airlines Logo
7:05 am - 1:55 pmDSM  Des Moines-SAT San Antonio
6h 50m1 stop Chicago O'Hare Intl
American Airlines Logo
5:43 pm - 11:07 pmSAT  San Antonio-DSM Des Moines
5h 24m1 stop Dallas/Fort Worth
$325American Airlines
Sat, Oct 3 - Wed, Oct 7
United Airlines Logo
5:45 am - 12:43 pmDSM  Des Moines-SAT San Antonio
6h 58m1 stop Denver Intl
United Airlines Logo
4:17 pm - 10:16 pmSAT  San Antonio-DSM Des Moines
5h 59m1 stop Houston George Bush Intcntl
$325United Airlines
Sat, Sep 19 - Sat, Sep 26
United Airlines Logo
1:27 pm - 8:53 pmDSM  Des Moines-SAT San Antonio
7h 26m1 stop Denver Intl
United Airlines Logo
1:52 pm - 8:36 pmSAT  San Antonio-DSM Des Moines
6h 44m1 stop Denver Intl
$325United Airlines
Wed, Nov 4 - Mon, Nov 9
Delta Logo
2:43 pm - 9:26 pmDSM  Des Moines-SAT San Antonio
6h 43m1 stop Minneapolis St Paul
Delta Logo
2:33 pm - 7:15 pmSAT  San Antonio-DSM Des Moines
4h 42m1 stop Minneapolis St Paul
$325Delta
Tue, Nov 10 - Wed, Nov 18
Delta Logo
3:03 pm - 9:48 pmDSM  Des Moines-SAT San Antonio
6h 45m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:00 pm - 10:33 pmSAT  San Antonio-DSM Des Moines
8h 33m1 stop Atlanta Hartsfield-Jackson
$325Delta
Wed, Oct 28 - Sat, Oct 31
Southwest Logo
7:10 pm - 11:55 pmDSM  Des Moines-SAT San Antonio
4h 45m1 stop Denver Intl
Southwest Logo
12:20 pm - 9:55 pmSAT  San Antonio-DSM Des Moines
9h 35m2 stops Dallas Love Field Denver Intl
$330Southwest
Thu, Oct 1 - Mon, Oct 5
Southwest Logo
7:10 pm - 11:55 pmDSM  Des Moines-SAT San Antonio
4h 45m1 stop Denver Intl
Southwest Logo
6:15 am - 2:20 pmSAT  San Antonio-DSM Des Moines
8h 05m2 stops Las Vegas Harry Reid Intl Denver Intl
$330Southwest
Mon, Oct 5 - Tue, Oct 13

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Frontier flights from Des Moines to San Antonio

Our best Frontier deals on Des Moines to San Antonio flight tickets
Frontier
Oct 16
DSM8:25 pmDes Moines
23h 01m
1 stop
SAT7:26 pmSan Antonio
Oct 18
SAT8:21 pmSan Antonio
23h 09m
1 stop
DSM7:30 pmDes Moines
$257
Frontier
Sep 28
DSM8:30 pmDes Moines
22h 55m
1 stop
SAT7:25 pmSan Antonio
Oct 20
SAT8:21 pmSan Antonio
16h 57m
1 stop
DSM1:18 pmDes Moines
$270
Frontier
Oct 4
DSM11:29 amDes Moines
7h 56m
1 stop
SAT7:25 pmSan Antonio
Oct 8
SAT8:21 pmSan Antonio
23h 09m
1 stop
DSM7:30 pmDes Moines
$283

American Airlines flights from Des Moines to San Antonio

Our best American Airlines deals on Des Moines to San Antonio flight tickets
American Airlines
Nov 10
DSM9:27 amDes Moines
7h 35m
2 stops
SAT5:02 pmSan Antonio
Nov 18
SAT6:36 pmSan Antonio
5h 38m
1 stop
DSM12:14 amDes Moines
$344
American Airlines
Nov 10
DSM9:27 amDes Moines
7h 35m
2 stops
SAT5:02 pmSan Antonio
Nov 18
SAT6:36 pmSan Antonio
5h 38m
1 stop
DSM12:14 amDes Moines
$351
American Airlines
Nov 10
DSM9:27 amDes Moines
7h 35m
2 stops
SAT5:02 pmSan Antonio
Nov 18
SAT6:36 pmSan Antonio
5h 38m
1 stop
DSM12:14 amDes Moines
$352

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

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Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Fri 10/16

8:25 pm-7:26 pm

1 stop23h 01m

San Antonio

Sun 10/18

8:21 pm-7:30 pm

1 stop23h 09m

$257

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Fri 11/13

2:51 pm-10:12 am

1 stop19h 21m

San Antonio

Sun 11/15

11:08 am-1:56 pm

1 stop26h 48m

$257

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 10/1

5:56 pm-11:55 pm

1 stop5h 59m

San Antonio

Mon 10/5

4:28 pm-11:07 pm

1 stop6h 39m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Sat 10/3

7:05 am-1:55 pm

1 stop6h 50m

San Antonio

Wed 10/7

5:43 pm-11:07 pm

1 stop5h 24m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Sat 9/19

5:45 am-12:43 pm

1 stop6h 58m

San Antonio

Sat 9/26

4:17 pm-10:16 pm

1 stop5h 59m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Wed 11/4

1:27 pm-8:53 pm

1 stop7h 26m

San Antonio

Mon 11/9

1:52 pm-8:36 pm

1 stop6h 44m

$325
Quickest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Tue 11/10

2:43 pm-9:26 pm

1 stop6h 43m

San Antonio

Wed 11/18

2:33 pm-7:15 pm

1 stop4h 42m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Wed 10/28

3:03 pm-9:48 pm

1 stop6h 45m

San Antonio

Sat 10/31

2:00 pm-10:33 pm

1 stop8h 33m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 10/1

7:10 pm-11:55 pm

1 stop4h 45m

San Antonio

Mon 10/5

12:20 pm-9:55 pm

2 stops9h 35m

$330

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Mon 10/5

7:10 pm-11:55 pm

1 stop4h 45m

San Antonio

Tue 10/13

6:15 am-2:20 pm

2 stops8h 05m

$330

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Antonio?

Prices are currently low for flights on this route.

Typical prices usually range from $371 to $582.
The lowest price recently found on this route was $257.

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of November, then book flights to San Antonio from Des Moines during April instead. Flights to San Antonio in April, while not as cheap as those in November, still average around $386.

How have Des Moines to San Antonio flight prices changed over time?

As of August 2026, prices for Des Moines to San Antonio flights are approximately 6% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Best Price Found

$113

Fastest flight time

5h 16m

Direct flights

None
The best one-way flight to San Antonio from Des Moines in the past 72 hours is $113. The best round-trip flight deal from Des Moines to San Antonio found on momondo in the last 72 hours is $257.
The fastest flight from Des Moines to San Antonio takes 5h 16m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

Frequently asked questions about flying from Des Moines to San Antonio

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 5h 16m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $213Free CancellationRating
7.8
8,505 reviews
Search Delta flights
American AirlinesPriceFrom $306Free CancellationRating
7.1
11,968 reviews
Search American Airlines flights
United AirlinesPriceFrom $312Free CancellationRating
7.4
10,102 reviews
Search United Airlines flights
SouthwestPriceFrom $359Free CancellationRating
8.0
4,215 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Pleasanton
Kerrville
Boerne
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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