Which layover airport has the shortest connection time from Des Moines to San Antonio?

Minneapolis (MSP) has the shortest average layover time for this route: 1h 38m.

Which layover airport offers the lowest fares from Des Moines to San Antonio?

Flights via Minneapolis (MSP) offer the lowest average round-trip price of $289.

Which airport is the most popular layover for flights between Des Moines and San Antonio?

Minneapolis (MSP) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest travel time from Des Moines to San Antonio?

Flights connecting via Dallas (DFW) have the shortest average one-way travel time: 4h 03m.

What is the cheapest airline that flies from Des Moines to San Antonio?

Frontier, Delta, and United Airlines are the most popular carriers operating from Des Moines to San Antonio

What airlines fly to San Antonio?

Allegiant Air, American Airlines and United Airlines are the top three most popular airlines that fly to San Antonio from Des Moines according to our data. Allegiant Air is the first choice among our users, with 42% of people opting to fly with this airline when traveling to San Antonio. Keep in mind that there are 5 different airlines that fly to San Antonio on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

The number of operators available for flights from Des Moines Airport to San Antonio Airport is 4 as of October 2026.

How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

What documentation or ID do you need to fly to San Antonio Airport?

The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$122 Cheap Flights from Des Moines to San Antonio in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Antonio

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One-way

Cheap round-trip flights

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3:25 pm - 11:45 pmDSM Des Moines-SAT San Antonio

8h 20m1 stop Chicago Midway

2:40 pm - 10:05 pmSAT San Antonio-DSM Des Moines

7h 25m1 stop Chicago Midway

$281Southwest

Mon, Dec 7 - Thu, Dec 10

2:58 pm - 10:19 pmDSM Des Moines-SAT San Antonio

7h 21m1 stop Atlanta Hartsfield-Jackson

5:16 am - 10:53 amSAT San Antonio-DSM Des Moines

5h 37m1 stop Atlanta Hartsfield-Jackson

$281Delta

Tue, Dec 8 - Thu, Dec 10

2:56 pm - 9:26 pmDSM Des Moines-SAT San Antonio

6h 30m1 stop Houston George Bush Intcntl

5:45 pm - 10:21 pmSAT San Antonio-DSM Des Moines

4h 36m1 stop Houston George Bush Intcntl

$281United Airlines

Thu, Dec 3 - Mon, Dec 7

2:56 pm - 9:26 pmDSM Des Moines-SAT San Antonio

6h 30m1 stop Houston George Bush Intcntl

5:58 pm - 10:29 pmSAT San Antonio-DSM Des Moines

4h 31m1 stop Houston George Bush Intcntl

$281United Airlines

Mon, Dec 14 - Thu, Dec 17

3:25 pm - 11:45 pmDSM Des Moines-SAT San Antonio

8h 20m1 stop Chicago Midway

12:50 pm - 8:50 pmSAT San Antonio-DSM Des Moines

8h 00m2 stops Houston Hobby Denver Intl

$286Southwest

Mon, Dec 7 - Thu, Dec 10

3:30 pm - 11:45 pmDSM Des Moines-SAT San Antonio

8h 15m1 stop Chicago Midway

1:00 pm - 8:50 pmSAT San Antonio-DSM Des Moines

7h 50m2 stops Dallas Love Field Denver Intl

$286Southwest

Thu, Dec 3 - Mon, Dec 7

5:23 am - 9:48 amDSM Des Moines-SAT San Antonio

4h 25m1 stop Dallas/Fort Worth

5:37 pm - 11:23 pmSAT San Antonio-DSM Des Moines

5h 46m1 stop Dallas/Fort Worth

$301American Airlines

Fri, Nov 27 - Tue, Dec 1

7:16 pm - 12:06 amDSM Des Moines-SAT San Antonio

4h 50m1 stop Dallas/Fort Worth

2:03 pm - 6:27 pmSAT San Antonio-DSM Des Moines

4h 24m1 stop Dallas/Fort Worth

$316American Airlines

Fri, Nov 27 - Tue, Dec 1

6:53 pm - 12:35 amDSM Des Moines-SAT San Antonio

5h 42m1 stop Atlanta Hartsfield-Jackson

2:29 pm - 9:31 pmSAT San Antonio-DSM Des Moines

7h 02m1 stop Minneapolis St Paul

$370Delta

Fri, Dec 11 - Fri, Dec 18

2:45 pm - 9:34 pmDSM Des Moines-SAT San Antonio

30h 49m1 stop Las Vegas Harry Reid Intl

10:29 pm - 7:35 pmSAT San Antonio-DSM Des Moines

21h 06m2 stops Las Vegas Harry Reid Intl Denver Intl

$468Multiple Airlines

Wed, Nov 11 - Sun, Nov 15

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American Airlines flights from Des Moines to San Antonio

Our best American Airlines deals on Des Moines to San Antonio flight tickets

American Airlines

Nov 27

DSM5:23 amDes Moines

4h 25m

1 stop

SAT9:48 amSan Antonio

Dec 1

SAT5:37 pmSan Antonio

5h 46m

1 stop

DSM11:23 pmDes Moines

$301

American Airlines

Nov 27

DSM7:16 pmDes Moines

4h 50m

1 stop

SAT12:06 amSan Antonio

Dec 1

SAT2:03 pmSan Antonio

4h 24m

1 stop

DSM6:27 pmDes Moines

$316

American Airlines

Nov 19

DSM7:11 amDes Moines

6h 31m

1 stop

SAT1:42 pmSan Antonio

Nov 22

SAT5:00 amSan Antonio

4h 07m

1 stop

DSM9:07 amDes Moines

$330

Southwest flights from Des Moines to San Antonio

Our best Southwest deals on Des Moines to San Antonio flight tickets

Southwest

Dec 3

DSM3:30 pmDes Moines

8h 15m

1 stop

SAT11:45 pmSan Antonio

Dec 7

SAT1:00 pmSan Antonio

7h 50m

2 stops

DSM8:50 pmDes Moines

$286

Southwest

Dec 1

DSM7:00 amDes Moines

5h 05m

1 stop

SAT12:05 pmSan Antonio

Dec 3

SAT2:40 pmSan Antonio

7h 25m

1 stop

DSM10:05 pmDes Moines

$325

Southwest

Feb 1

DSM10:50 amDes Moines

11h 05m

2 stops

SAT9:55 pmSan Antonio

Feb 5

SAT5:25 amSan Antonio

7h 45m

2 stops

DSM1:10 pmDes Moines

$349

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Mon 12/7

3:25 pm-11:45 pm

1 stop8h 20m

San Antonio

Thu 12/10

2:40 pm-10:05 pm

1 stop7h 25m

$281

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Tue 12/8

2:58 pm-10:19 pm

1 stop7h 21m

San Antonio

Thu 12/10

5:16 am-10:53 am

1 stop5h 37m

$281

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 12/3

2:56 pm-9:26 pm

1 stop6h 30m

San Antonio

Mon 12/7

5:45 pm-10:21 pm

1 stop4h 36m

$281

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Mon 12/14

2:56 pm-9:26 pm

1 stop6h 30m

San Antonio

Thu 12/17

5:58 pm-10:29 pm

1 stop4h 31m

$281

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Mon 12/7

3:25 pm-11:45 pm

1 stop8h 20m

San Antonio

Thu 12/10

12:50 pm-8:50 pm

2 stops8h 00m

$286

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 12/3

3:30 pm-11:45 pm

1 stop8h 15m

San Antonio

Mon 12/7

1:00 pm-8:50 pm

2 stops7h 50m

$286

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Fri 11/27

5:23 am-9:48 am

1 stop4h 25m

San Antonio

Tue 12/1

5:37 pm-11:23 pm

1 stop5h 46m

$301

Quickest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Fri 11/27

7:16 pm-12:06 am

1 stop4h 50m

San Antonio

Tue 12/1

2:03 pm-6:27 pm

1 stop4h 24m

$316

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Fri 12/11

6:53 pm-12:35 am

1 stop5h 42m

San Antonio

Fri 12/18

2:29 pm-9:31 pm

1 stop7h 02m

$370

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Wed 11/11

2:45 pm-9:34 pm

1 stop30h 49m

San Antonio

Sun 11/15

10:29 pm-7:35 pm

2 stops21h 06m

$468

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of December, then book flights to San Antonio from Des Moines during November instead. Flights to San Antonio in November, while not as cheap as those in December, still average around $370.

How far in advance should I book a flight from Des Moines to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $444 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $322 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of October 2026, prices for Des Moines to San Antonio flights are approximately 3% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Best Price Found	$122
Fastest flight time	5h 05m
Direct flights	None

The best one-way flight to San Antonio from Des Moines in the past 72 hours is $122. The best round-trip flight deal from Des Moines to San Antonio found on momondo in the last 72 hours is $281.

The fastest flight from Des Moines to San Antonio takes 5h 05m

There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.

Search flight deals

Frequently asked questions about flying from Des Moines to San Antonio

How far is Des Moines to San Antonio by plane?
Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 5h 05m.
When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?
Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.
How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?
The number of operators available for flights from Des Moines Airport to San Antonio Airport is 4 as of October 2026.
How old do you have to be to fly from Des Moines Airport to San Antonio Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.
What documentation or ID do you need to fly to San Antonio Airport?
The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to San Antonio?
momondo data reveals that the most frequently booked airline on the route from Des Moines to San Antonio is American Airlines, representing 49% of all bookings. The subsequent popular airlines are United Airlines at 34%, Delta at 10%, and Southwest at 7%.

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $268	Free Cancellation	Rating 7.8 8,698 reviews	Search Delta flights
United Airlines	PriceFrom $316	Free Cancellation	Rating 7.3 10,459 reviews	Search United Airlines flights
American Airlines	PriceFrom $316	Free Cancellation	Rating 7.0 12,223 reviews	Search American Airlines flights
Southwest	PriceFrom $324	Free Cancellation	Rating 7.9 4,225 reviews	Search Southwest flights

New Braunfels

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Pleasanton

Boerne

Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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Cheap flights from Des Moines to San Antonio from $122

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 12/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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American Airlines flights from Des Moines to San Antonio

Our best American Airlines deals on Des Moines to San Antonio flight tickets

Southwest flights from Des Moines to San Antonio

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How to get the cheapest flight ticket from Des Moines to San Antonio

What is the cheapest month to fly to San Antonio?

How far in advance should I book a flight from Des Moines to San Antonio?

How have Des Moines to San Antonio flight prices changed over time?

What is the cheapest airline that flies from Des Moines to San Antonio?

What airlines fly to San Antonio?

Which airport is the most popular layover for flights between Des Moines and San Antonio?

Which layover airport offers the lowest fares from Des Moines to San Antonio?

Which layover airport has the shortest travel time from Des Moines to San Antonio?

Which layover airport has the shortest connection time from Des Moines to San Antonio?

When to book flights from Des Moines to San Antonio

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

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Direct flights

Frequently asked questions about flying from Des Moines to San Antonio

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo

Traveling to a place near San Antonio?

Why use momondo?

An easier way to manage your San Antonio trip

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List of cabin classes available on flights landing in San Antonio. Availability may vary depending on flight origin and airline.

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