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Cheap flights from Des Moines to San Antonio from $123

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 11/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Multiple Airlines Logo
2:32 pm - 2:17 pmDSM-SAT
23h 45m1 stop
Multiple Airlines Logo
12:17 pm - 10:40 pmSAT-DSM
10h 23m1 stop
$228Multiple Airlines
Find Deal
vie., oct. 31 - vie., nov. 7
Multiple Airlines Logo
7:30 am - 11:40 pmDSM-SAT
16h 10m1 stop
Multiple Airlines Logo
7:00 am - 2:27 pmSAT-DSM
7h 27m1 stop
$238Multiple Airlines
Find Deal
mié., oct. 8 - mié., oct. 15
Delta Logo
10:00 am - 3:56 pmDSM-SAT
5h 56m1 stop
Delta Logo
6:25 am - 1:59 pmSAT-DSM
7h 34m1 stop
$305Delta
Find Deal
jue., oct. 30 - mar., nov. 4
Southwest Logo
7:25 am - 3:05 pmDSM-SAT
7h 40m1 stop
Southwest Logo
7:25 am - 3:05 pmSAT-DSM
7h 40m2 stops
$310Southwest
Find Deal
mié., oct. 29 - sáb., nov. 1
Delta Logo
3:30 pm - 9:10 pmDSM-SAT
5h 40m1 stop
Delta Logo
2:55 pm - 10:30 pmSAT-DSM
7h 35m1 stop
$313Delta
Find Deal
sáb., oct. 11 - sáb., oct. 18
Southwest Logo
6:20 am - 2:50 pmDSM-SAT
8h 30m2 stops
Southwest Logo
7:25 am - 3:05 pmSAT-DSM
7h 40m2 stops
$315Southwest
Find Deal
mié., oct. 29 - sáb., nov. 1
American Airlines Logo
7:31 pm - 11:43 pmDSM-SAT
4h 12m1 stop
American Airlines Logo
6:24 pm - 11:23 pmSAT-DSM
4h 59m1 stop
$345American Airlines
Find Deal
jue., oct. 16 - lun., oct. 20
American Airlines Logo
11:32 am - 10:59 pmDSM-SAT
11h 27m1 stop
American Airlines Logo
10:35 am - 5:05 pmSAT-DSM
6h 30m1 stop
$369American Airlines
Find Deal
jue., dic. 25 - mar., dic. 30
United Airlines Logo
3:04 pm - 7:41 pmDSM-SAT
4h 37m1 stop
United Airlines Logo
4:04 pm - 10:55 amSAT-DSM
18h 51m2 stops
$378United Airlines
Find Deal
mié., ene. 28 - sáb., ene. 31
United Airlines Logo
9:01 am - 4:58 pmDSM-SAT
7h 57m1 stop
United Airlines Logo
5:30 am - 4:07 pmSAT-DSM
10h 37m2 stops
$380United Airlines
Find Deal
jue., oct. 30 - mar., nov. 4

Southwest flights from Des Moines to San Antonio

Our best Southwest deals on Des Moines to San Antonio flight tickets
Southwest
Oct 29
DSM7:25 amDes Moines
7h 40m
1 stop
SAT3:05 pmSan Antonio
Nov 1
SAT7:25 amSan Antonio
7h 40m
2 stops
DSM3:05 pmDes Moines
$310
Find similar
Southwest
Oct 29
DSM6:20 amDes Moines
8h 30m
2 stops
SAT2:50 pmSan Antonio
Nov 1
SAT7:25 amSan Antonio
7h 40m
2 stops
DSM3:05 pmDes Moines
$315
Find similar
Southwest
Oct 8
DSM3:00 pmDes Moines
8h 00m
2 stops
SAT11:00 pmSan Antonio
Oct 15
SAT12:45 pmSan Antonio
9h 05m
2 stops
DSM9:50 pmDes Moines
$342
Find similar

United Airlines flights from Des Moines to San Antonio

Our best United Airlines deals on Des Moines to San Antonio flight tickets
United Airlines
Jan 28
DSM3:04 pmDes Moines
4h 37m
1 stop
SAT7:41 pmSan Antonio
Jan 31
SAT4:04 pmSan Antonio
18h 51m
2 stops
DSM10:55 amDes Moines
$378
Find similar
United Airlines
Oct 30
DSM9:01 amDes Moines
7h 57m
1 stop
SAT4:58 pmSan Antonio
Nov 4
SAT5:30 amSan Antonio
10h 37m
2 stops
DSM4:07 pmDes Moines
$380
Find similar
United Airlines
Dec 25
DSM1:30 pmDes Moines
9h 18m
2 stops
SAT10:48 pmSan Antonio
Dec 30
SAT11:28 amSan Antonio
10h 12m
2 stops
DSM9:40 pmDes Moines
$385
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated septiembre 16, 2025.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

vie. 10/31

2:32 pm-2:17 pm

1 stop23h 45m

San Antonio

vie. 11/7

12:17 pm-10:40 pm

1 stop10h 23m

$228

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mié. 10/8

7:30 am-11:40 pm

1 stop16h 10m

San Antonio

mié. 10/15

7:00 am-2:27 pm

1 stop7h 27m

$238

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jue. 10/30

10:00 am-3:56 pm

1 stop5h 56m

San Antonio

mar. 11/4

6:25 am-1:59 pm

1 stop7h 34m

$305

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mié. 10/29

7:25 am-3:05 pm

1 stop7h 40m

San Antonio

sáb. 11/1

7:25 am-3:05 pm

2 stops7h 40m

$310

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

sáb. 10/11

3:30 pm-9:10 pm

1 stop5h 40m

San Antonio

sáb. 10/18

2:55 pm-10:30 pm

1 stop7h 35m

$313

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mié. 10/29

6:20 am-2:50 pm

2 stops8h 30m

San Antonio

sáb. 11/1

7:25 am-3:05 pm

2 stops7h 40m

$315

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jue. 10/16

7:31 pm-11:43 pm

1 stop4h 12m

San Antonio

lun. 10/20

6:24 pm-11:23 pm

1 stop4h 59m

$345

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jue. 12/25

11:32 am-10:59 pm

1 stop11h 27m

San Antonio

mar. 12/30

10:35 am-5:05 pm

1 stop6h 30m

$369

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mié. 1/28

3:04 pm-7:41 pm

1 stop4h 37m

San Antonio

sáb. 1/31

4:04 pm-10:55 am

2 stops18h 51m

$378

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jue. 10/30

9:01 am-4:58 pm

1 stop7h 57m

San Antonio

mar. 11/4

5:30 am-4:07 pm

2 stops10h 37m

$380

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of August, then book flights to San Antonio from Des Moines during July instead. Flights to San Antonio in July, while not as cheap as those in August, still average around $334.

What is the cheapest day to depart on your flight to San Antonio?

The cheapest day to depart on your flight to San Antonio is on a Wednesday when prices can be found for as low as $366. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to San Antonio on Monday is $411.

What is the cheapest time of day to depart on your flight to San Antonio?

According to our data, the cheapest time of day to fly to San Antonio is in the evening. momondo users have found flights departing from Des Moines to San Antonio in the evening for as low as $301. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to San Antonio are more costly in the morning, with an average ticket price of $402. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $401 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $328 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of September 2025, prices for Des Moines to San Antonio flights are approximately 17% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Direct flights

None
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 12m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $276Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $283Free CancellationRating
7.9
7,957 reviews
Search Delta flights
United AirlinesPriceFrom $302Free CancellationRating
7.4
8,924 reviews
Search United Airlines flights
SouthwestPriceFrom $327Free CancellationRating
8.0
4,242 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Schertz
Pleasanton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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