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Cheap flights from Des Moines to San Antonio from $116

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 9/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
11:29 am - 7:25 pmDSM  Des Moines-SAT San Antonio
7h 56m1 stop Denver Intl
Frontier Logo
8:20 pm - 10:44 amSAT  San Antonio-DSM Des Moines
14h 24m1 stop Denver Intl
$242Frontier
Thu, Sep 10 - Sat, Sep 12
Frontier Logo
2:31 pm - 11:21 amDSM  Des Moines-SAT San Antonio
20h 50m1 stop Denver Intl
Frontier Logo
12:16 pm - 1:18 pmSAT  San Antonio-DSM Des Moines
25h 02m1 stop Denver Intl
$242Frontier
Mon, Oct 12 - Thu, Oct 15
American Airlines Logo
7:40 pm - 11:55 pmDSM  Des Moines-SAT San Antonio
4h 15m1 stop Dallas/Fort Worth
American Airlines Logo
6:48 pm - 12:04 amSAT  San Antonio-DSM Des Moines
5h 16m1 stop Chicago O'Hare Intl
$326American Airlines
Thu, Sep 10 - Fri, Sep 11
United Airlines Logo
3:02 pm - 9:16 pmDSM  Des Moines-SAT San Antonio
6h 14m1 stop Houston George Bush Intcntl
United Airlines Logo
4:12 pm - 10:30 pmSAT  San Antonio-DSM Des Moines
6h 18m1 stop Houston George Bush Intcntl
$327United Airlines
Wed, Sep 9 - Thu, Sep 10
Southwest Logo
2:25 pm - 10:00 pmDSM  Des Moines-SAT San Antonio
7h 35m2 stops Denver Intl Houston Hobby
Southwest Logo
2:15 pm - 10:15 pmSAT  San Antonio-DSM Des Moines
8h 00m1 stop Chicago Midway
$331Southwest
Thu, Sep 10 - Fri, Sep 11
Southwest Logo
6:10 am - 12:50 pmDSM  Des Moines-SAT San Antonio
6h 40m2 stops Chicago Midway Dallas Love Field
Southwest Logo
2:20 pm - 9:20 pmSAT  San Antonio-DSM Des Moines
7h 00m1 stop Denver Intl
$332Southwest
Wed, Sep 9 - Thu, Sep 10
Delta Logo
6:30 pm - 12:28 amDSM  Des Moines-SAT San Antonio
5h 58m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:10 pm - 10:29 pmSAT  San Antonio-DSM Des Moines
8h 19m1 stop Atlanta Hartsfield-Jackson
$338Delta
Fri, Dec 25 - Tue, Jan 5
Delta Logo
6:54 pm - 12:33 amDSM  Des Moines-SAT San Antonio
5h 39m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:29 pm - 10:33 pmSAT  San Antonio-DSM Des Moines
6h 04m1 stop Atlanta Hartsfield-Jackson
$338Delta
Thu, Oct 29 - Fri, Oct 30
American Airlines Logo
6:55 am - 12:53 pmDSM  Des Moines-SAT San Antonio
5h 58m1 stop Chicago O'Hare Intl
American Airlines Logo
2:03 pm - 6:58 pmSAT  San Antonio-DSM Des Moines
4h 55m1 stop Dallas/Fort Worth
$339American Airlines
Thu, Sep 3 - Thu, Sep 10
United Airlines Logo
6:15 am - 10:36 amDSM  Des Moines-SAT San Antonio
4h 21m1 stop Houston George Bush Intcntl
United Airlines Logo
6:30 am - 2:16 pmSAT  San Antonio-DSM Des Moines
7h 46m1 stop Chicago O'Hare Intl
$351United Airlines
Wed, Aug 26 - Thu, Aug 27

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Delta flights from Des Moines to San Antonio

Our best Delta deals on Des Moines to San Antonio flight tickets
Delta
Oct 29
DSM6:54 pmDes Moines
5h 39m
1 stop
SAT12:33 amSan Antonio
Oct 30
SAT4:29 pmSan Antonio
6h 04m
1 stop
DSM10:33 pmDes Moines
$338
Delta
Nov 10
DSM2:43 pmDes Moines
6h 43m
1 stop
SAT9:26 pmSan Antonio
Nov 18
SAT2:33 pmSan Antonio
4h 42m
1 stop
DSM7:15 pmDes Moines
$351
Delta
Sep 18
DSM11:31 amDes Moines
5h 30m
1 stop
SAT5:01 pmSan Antonio
Sep 21
SAT4:21 pmSan Antonio
6h 05m
1 stop
DSM10:26 pmDes Moines
$368

Frontier flights from Des Moines to San Antonio

Our best Frontier deals on Des Moines to San Antonio flight tickets
Frontier
Sep 17
DSM11:29 amDes Moines
7h 56m
1 stop
SAT7:25 pmSan Antonio
Sep 24
SAT8:20 pmSan Antonio
23h 13m
1 stop
DSM7:33 pmDes Moines
$242
Frontier
Sep 17
DSM11:29 amDes Moines
7h 56m
1 stop
SAT7:25 pmSan Antonio
Sep 24
SAT8:20 pmSan Antonio
23h 13m
1 stop
DSM7:33 pmDes Moines
$249
Frontier
Oct 1
DSM11:29 amDes Moines
7h 56m
1 stop
SAT7:25 pmSan Antonio
Oct 4
SAT8:20 pmSan Antonio
23h 13m
1 stop
DSM7:33 pmDes Moines
$257

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 9/10

11:29 am-7:25 pm

1 stop7h 56m

San Antonio

Sat 9/12

8:20 pm-10:44 am

1 stop14h 24m

$242

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Mon 10/12

2:31 pm-11:21 am

1 stop20h 50m

San Antonio

Thu 10/15

12:16 pm-1:18 pm

1 stop25h 02m

$242
Quickest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 9/10

7:40 pm-11:55 pm

1 stop4h 15m

San Antonio

Fri 9/11

6:48 pm-12:04 am

1 stop5h 16m

$326

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Wed 9/9

3:02 pm-9:16 pm

1 stop6h 14m

San Antonio

Thu 9/10

4:12 pm-10:30 pm

1 stop6h 18m

$327

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 9/10

2:25 pm-10:00 pm

2 stops7h 35m

San Antonio

Fri 9/11

2:15 pm-10:15 pm

1 stop8h 00m

$331

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Wed 9/9

6:10 am-12:50 pm

2 stops6h 40m

San Antonio

Thu 9/10

2:20 pm-9:20 pm

1 stop7h 00m

$332

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Fri 12/25

6:30 pm-12:28 am

1 stop5h 58m

San Antonio

Tue 1/5

2:10 pm-10:29 pm

1 stop8h 19m

$338

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 10/29

6:54 pm-12:33 am

1 stop5h 39m

San Antonio

Fri 10/30

4:29 pm-10:33 pm

1 stop6h 04m

$338

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 9/3

6:55 am-12:53 pm

1 stop5h 58m

San Antonio

Thu 9/10

2:03 pm-6:58 pm

1 stop4h 55m

$339

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Wed 8/26

6:15 am-10:36 am

1 stop4h 21m

San Antonio

Thu 8/27

6:30 am-2:16 pm

1 stop7h 46m

$351

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Antonio?

Prices are currently low for flights on this route.

Typical prices usually range from $289 to $541.
The lowest price recently found on this route was $242.

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of November, then book flights to San Antonio from Des Moines during April instead. Flights to San Antonio in April, while not as cheap as those in November, still average around $386.

How have Des Moines to San Antonio flight prices changed over time?

As of August 2026, prices for Des Moines to San Antonio flights are approximately 6% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Fastest flight time

4h 06m

Direct flights

None
The fastest flight from Des Moines to San Antonio takes 4h 06m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

Frequently asked questions about flying from Des Moines to San Antonio

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 06m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $213Free CancellationRating
7.8
8,491 reviews
Search Delta flights
American AirlinesPriceFrom $293Free CancellationRating
7.1
11,848 reviews
Search American Airlines flights
United AirlinesPriceFrom $312Free CancellationRating
7.4
10,058 reviews
Search United Airlines flights
SouthwestPriceFrom $359Free CancellationRating
8.0
4,220 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Pleasanton
Boerne
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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