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Cheap flights from Des Moines to San Antonio from $132

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 8/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
2:45 pm - 9:29 pm
DSM
-
SAT
6h 44m
1 stop
Delta Logo
5:20 am - 10:43 am
SAT
-
DSM
5h 23m
1 stop
$263Delta
Tue, Aug 4 - Tue, Aug 11
Frontier Logo
2:19 pm - 7:31 pm
DSM
-
SAT
5h 12m
1 stop
Frontier Logo
8:26 pm - 1:34 pm
SAT
-
DSM
17h 08m
1 stop
$264Frontier
Fri, Aug 21 - Thu, Aug 27
United Airlines Logo
3:02 pm - 9:16 pm
DSM
-
SAT
6h 14m
1 stop
United Airlines Logo
5:30 am - 12:32 pm
SAT
-
DSM
7h 02m
2 stops
$268United Airlines
Wed, Aug 12 - Thu, Aug 27
Southwest Logo
2:25 pm - 7:10 pm
DSM
-
SAT
4h 45m
1 stop
Southwest Logo
3:30 pm - 10:10 pm
SAT
-
DSM
6h 40m
2 stops
$269Southwest
Thu, Sep 17 - Mon, Sep 21
Southwest Logo
3:50 pm - 10:55 pm
DSM
-
SAT
7h 05m
2 stops
Southwest Logo
1:10 pm - 8:45 pm
SAT
-
DSM
7h 35m
1 stop
$270Southwest
Thu, Aug 13 - Sat, Aug 22
Southwest Logo
6:10 am - 12:50 pm
DSM
-
SAT
6h 40m
2 stops
Southwest Logo
6:00 am - 1:45 pm
SAT
-
DSM
7h 45m
2 stops
$275Southwest
Wed, Aug 12 - Thu, Aug 27
Southwest Logo
3:50 pm - 10:55 pm
DSM
-
SAT
7h 05m
2 stops
Southwest Logo
9:45 am - 8:45 pm
SAT
-
DSM
11h 00m
2 stops
$281Southwest
Thu, Aug 13 - Sat, Aug 22
Southwest Logo
2:25 pm - 9:55 pm
DSM
-
SAT
7h 30m
2 stops
Southwest Logo
6:00 am - 1:45 pm
SAT
-
DSM
7h 45m
2 stops
$311Southwest
Fri, Aug 21 - Thu, Aug 27
Southwest Logo
2:40 pm - 10:55 pm
DSM
-
SAT
8h 15m
2 stops
Southwest Logo
3:25 pm - 10:10 pm
SAT
-
DSM
6h 45m
2 stops
$317Southwest
Wed, Aug 5 - Fri, Aug 7
Southwest Logo
7:10 pm - 11:55 pm
DSM
-
SAT
4h 45m
1 stop
Southwest Logo
5:30 am - 1:35 pm
SAT
-
DSM
8h 05m
2 stops
$340Southwest
Thu, Oct 15 - Sun, Oct 18

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Delta flights from Des Moines to San Antonio

Our best Delta deals on Des Moines to San Antonio flight tickets
Delta
Aug 4
DSM2:45 pmDes Moines
6h 44m
1 stop
SAT9:29 pmSan Antonio
Aug 11
SAT5:20 amSan Antonio
5h 23m
1 stop
DSM10:43 amDes Moines
$263
Delta
Oct 4
DSM6:54 pmDes Moines
5h 16m
1 stop
SAT12:10 amSan Antonio
Oct 7
SAT4:29 pmSan Antonio
6h 05m
1 stop
DSM10:34 pmDes Moines
$335
Delta
Aug 13
DSM5:40 amDes Moines
7h 58m
1 stop
SAT1:38 pmSan Antonio
Aug 16
SAT6:30 amSan Antonio
7h 34m
1 stop
DSM2:04 pmDes Moines
$407

Southwest flights from Des Moines to San Antonio

Our best Southwest deals on Des Moines to San Antonio flight tickets
Southwest
Aug 21
DSM2:25 pmDes Moines
4h 45m
1 stop
SAT7:10 pmSan Antonio
Aug 27
SAT6:00 amSan Antonio
7h 45m
2 stops
DSM1:45 pmDes Moines
$269
Southwest
Aug 13
DSM3:50 pmDes Moines
7h 05m
2 stops
SAT10:55 pmSan Antonio
Aug 22
SAT1:10 pmSan Antonio
7h 35m
1 stop
DSM8:45 pmDes Moines
$270
Southwest
Aug 21
DSM3:50 pmDes Moines
7h 05m
2 stops
SAT10:55 pmSan Antonio
Aug 27
SAT5:35 amSan Antonio
8h 10m
2 stops
DSM1:45 pmDes Moines
$274

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 10, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Tue 8/4

2:45 pm-9:29 pm

1 stop6h 44m

San Antonio

Tue 8/11

5:20 am-10:43 am

1 stop5h 23m

$263

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 8/21

2:19 pm-7:31 pm

1 stop5h 12m

San Antonio

Thu 8/27

8:26 pm-1:34 pm

1 stop17h 08m

$264

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 8/12

3:02 pm-9:16 pm

1 stop6h 14m

San Antonio

Thu 8/27

5:30 am-12:32 pm

2 stops7h 02m

$268
Quickest round-trip

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 9/17

2:25 pm-7:10 pm

1 stop4h 45m

San Antonio

Mon 9/21

3:30 pm-10:10 pm

2 stops6h 40m

$269

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 8/13

3:50 pm-10:55 pm

2 stops7h 05m

San Antonio

Sat 8/22

1:10 pm-8:45 pm

1 stop7h 35m

$270

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 8/12

6:10 am-12:50 pm

2 stops6h 40m

San Antonio

Thu 8/27

6:00 am-1:45 pm

2 stops7h 45m

$275

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 8/13

3:50 pm-10:55 pm

2 stops7h 05m

San Antonio

Sat 8/22

9:45 am-8:45 pm

2 stops11h 00m

$281

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 8/21

2:25 pm-9:55 pm

2 stops7h 30m

San Antonio

Thu 8/27

6:00 am-1:45 pm

2 stops7h 45m

$311

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 8/5

2:40 pm-10:55 pm

2 stops8h 15m

San Antonio

Fri 8/7

3:25 pm-10:10 pm

2 stops6h 45m

$317

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 10/15

7:10 pm-11:55 pm

1 stop4h 45m

San Antonio

Sun 10/18

5:30 am-1:35 pm

2 stops8h 05m

$340

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of August, then book flights to San Antonio from Des Moines during December instead. Flights to San Antonio in December, while not as cheap as those in August, still average around $366.

How have Des Moines to San Antonio flight prices changed over time?

As of July 2026, prices for Des Moines to San Antonio flights are approximately 77% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Fastest flight time

4h 15m

Direct flights

None
The fastest flight from Des Moines to San Antonio takes 4h 15m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

Frequently asked questions about flying from Des Moines to San Antonio

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 15m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $213Free CancellationRating
7.8
8,456 reviews
Search Delta flights
American AirlinesPriceFrom $262Free CancellationRating
7.1
11,799 reviews
Search American Airlines flights
United AirlinesPriceFrom $312Free CancellationRating
7.4
9,966 reviews
Search United Airlines flights
SouthwestPriceFrom $359Free CancellationRating
7.9
4,248 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Pleasanton
Boerne
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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