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Cheap flights from Des Moines to San Antonio from $168

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 4/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:14 pm - 12:19 am
DSM
-
SAT
28h 05m
1 stop
Frontier Logo
6:45 am - 7:14 pm
SAT
-
DSM
12h 29m
1 stop
$191Frontier
Fri, Apr 3 - Mon, Apr 6
Frontier Logo
8:14 pm - 12:19 am
DSM
-
SAT
28h 05m
1 stop
Frontier Logo
6:45 am - 7:14 pm
SAT
-
DSM
12h 29m
1 stop
$192Frontier
Fri, Apr 10 - Mon, Apr 13
Frontier Logo
8:14 pm - 12:19 am
DSM
-
SAT
28h 05m
1 stop
Frontier Logo
6:45 am - 7:14 pm
SAT
-
DSM
12h 29m
1 stop
$212Frontier
Fri, Apr 10 - Mon, Apr 13
Frontier Logo
2:04 pm - 3:09 pm
DSM
-
SAT
25h 05m
1 stop
Frontier Logo
2:59 pm - 1:09 pm
SAT
-
DSM
22h 10m
1 stop
$312Frontier
Fri, Apr 24 - Sun, Apr 26
Frontier Logo
2:16 pm - 6:59 pm
DSM
-
SAT
28h 43m
1 stop
Frontier Logo
7:54 pm - 1:31 pm
SAT
-
DSM
17h 37m
1 stop
$314Frontier
Fri, May 15 - Tue, May 19
Frontier Logo
8:14 pm - 12:19 am
DSM
-
SAT
28h 05m
1 stop
Frontier Logo
6:45 am - 7:14 pm
SAT
-
DSM
12h 29m
1 stop
$319Frontier
Mon, Apr 6 - Fri, Apr 10
Frontier Logo
8:23 pm - 6:59 pm
DSM
-
SAT
22h 36m
1 stop
Frontier Logo
7:54 pm - 1:31 pm
SAT
-
DSM
17h 37m
1 stop
$323Frontier
Mon, May 4 - Thu, May 7
Frontier Logo
8:14 pm - 12:19 am
DSM
-
SAT
28h 05m
1 stop
Frontier Logo
6:45 am - 7:14 pm
SAT
-
DSM
12h 29m
1 stop
$326Frontier
Mon, Apr 6 - Fri, Apr 10
United Airlines Logo
8:20 am - 3:46 pm
DSM
-
SAT
7h 26m
1 stop
United Airlines Logo
6:02 pm - 10:43 pm
SAT
-
DSM
4h 41m
1 stop
$335United Airlines
Wed, Apr 15 - Wed, Apr 22
United Airlines Logo
3:04 pm - 7:48 pm
DSM
-
SAT
4h 44m
1 stop
United Airlines Logo
7:40 am - 4:15 pm
SAT
-
DSM
8h 35m
2 stops
$340United Airlines
Wed, Apr 15 - Wed, Apr 22

Frontier flights from Des Moines to San Antonio

Our best Frontier deals on Des Moines to San Antonio flight tickets
Frontier
Apr 3
DSM8:14 pmDes Moines
28h 05m
1 stop
SAT12:19 amSan Antonio
Apr 6
SAT6:45 amSan Antonio
12h 29m
1 stop
DSM7:14 pmDes Moines
$191
Frontier
Apr 10
DSM8:14 pmDes Moines
28h 05m
1 stop
SAT12:19 amSan Antonio
Apr 13
SAT6:45 amSan Antonio
12h 29m
1 stop
DSM7:14 pmDes Moines
$192
Frontier
Apr 10
DSM8:14 pmDes Moines
28h 05m
1 stop
SAT12:19 amSan Antonio
Apr 13
SAT6:45 amSan Antonio
12h 29m
1 stop
DSM7:14 pmDes Moines
$212

United Airlines flights from Des Moines to San Antonio

Our best United Airlines deals on Des Moines to San Antonio flight tickets
United Airlines
Apr 15
DSM8:20 amDes Moines
7h 26m
1 stop
SAT3:46 pmSan Antonio
Apr 22
SAT6:02 pmSan Antonio
4h 41m
1 stop
DSM10:43 pmDes Moines
$335
United Airlines
Apr 15
DSM3:04 pmDes Moines
4h 44m
1 stop
SAT7:48 pmSan Antonio
Apr 22
SAT7:40 amSan Antonio
8h 35m
2 stops
DSM4:15 pmDes Moines
$340
United Airlines
Apr 20
DSM3:04 pmDes Moines
4h 44m
1 stop
SAT7:48 pmSan Antonio
Apr 22
SAT5:50 pmSan Antonio
5h 27m
1 stop
DSM11:17 pmDes Moines
$350

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 4/3

8:14 pm-12:19 am

1 stop28h 05m

San Antonio

Mon 4/6

6:45 am-7:14 pm

1 stop12h 29m

$191

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 4/10

8:14 pm-12:19 am

1 stop28h 05m

San Antonio

Mon 4/13

6:45 am-7:14 pm

1 stop12h 29m

$192

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 4/10

8:14 pm-12:19 am

1 stop28h 05m

San Antonio

Mon 4/13

6:45 am-7:14 pm

1 stop12h 29m

$212

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 4/24

2:04 pm-3:09 pm

1 stop25h 05m

San Antonio

Sun 4/26

2:59 pm-1:09 pm

1 stop22h 10m

$312

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 5/15

2:16 pm-6:59 pm

1 stop28h 43m

San Antonio

Tue 5/19

7:54 pm-1:31 pm

1 stop17h 37m

$314

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Mon 4/6

8:14 pm-12:19 am

1 stop28h 05m

San Antonio

Fri 4/10

6:45 am-7:14 pm

1 stop12h 29m

$319

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Mon 5/4

8:23 pm-6:59 pm

1 stop22h 36m

San Antonio

Thu 5/7

7:54 pm-1:31 pm

1 stop17h 37m

$323

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Mon 4/6

8:14 pm-12:19 am

1 stop28h 05m

San Antonio

Fri 4/10

6:45 am-7:14 pm

1 stop12h 29m

$326
Quickest round-trip

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 4/15

8:20 am-3:46 pm

1 stop7h 26m

San Antonio

Wed 4/22

6:02 pm-10:43 pm

1 stop4h 41m

$335

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 4/15

3:04 pm-7:48 pm

1 stop4h 44m

San Antonio

Wed 4/22

7:40 am-4:15 pm

2 stops8h 35m

$340

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of August, then book flights to San Antonio from Des Moines during July instead. Flights to San Antonio in July, while not as cheap as those in August, still average around $334.

How far in advance should I book a flight to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $405 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $299 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of March 2026, prices for Des Moines to San Antonio flights are approximately 51% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Fastest flight time

6h 15m

Direct flights

None
The fastest flight from Des Moines to San Antonio takes 6h 15m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 6h 15m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $238Free CancellationRating
7.9
8,314 reviews
Search Delta flights
American AirlinesPriceFrom $266Free CancellationRating
7.1
11,489 reviews
Search American Airlines flights
United AirlinesPriceFrom $299Free CancellationRating
7.4
9,455 reviews
Search United Airlines flights
SouthwestPriceFrom $327Free CancellationRating
8.0
4,324 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Pleasanton
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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