Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to San Antonio from $135

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
2:48 pm - 9:26 pmDSM  Des Moines-SAT San Antonio
6h 38m1 stop Minneapolis St Paul
Delta Logo
2:33 pm - 7:15 pmSAT  San Antonio-DSM Des Moines
4h 42m1 stop Minneapolis St Paul
$269Delta
Tue, Nov 10 - Wed, Nov 18
Delta Logo
11:36 am - 7:48 pmDSM  Des Moines-SAT San Antonio
8h 12m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:30 am - 10:51 amSAT  San Antonio-DSM Des Moines
5h 21m1 stop Atlanta Hartsfield-Jackson
$269Delta
Tue, Nov 10 - Wed, Nov 18
United Airlines Logo
3:02 pm - 9:31 pmDSM  Des Moines-SAT San Antonio
6h 29m1 stop Houston George Bush Intcntl
United Airlines Logo
5:30 am - 12:31 pmSAT  San Antonio-DSM Des Moines
7h 01m1 stop Denver Intl
$269United Airlines
Sat, Oct 17 - Sat, Oct 24
United Airlines Logo
5:22 pm - 11:58 pmDSM  Des Moines-SAT San Antonio
6h 36m1 stop Denver Intl
United Airlines Logo
5:30 am - 12:42 pmSAT  San Antonio-DSM Des Moines
7h 12m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$274United Airlines
Sat, Oct 17 - Sat, Oct 24
Southwest Logo
7:05 am - 2:00 pmDSM  Des Moines-SAT San Antonio
6h 55m1 stop Denver Intl
Southwest Logo
6:45 am - 2:15 pmSAT  San Antonio-DSM Des Moines
7h 30m2 stops Dallas Love Field Denver Intl
$275Southwest
Wed, Oct 28 - Wed, Nov 4
Southwest Logo
12:10 pm - 9:40 pmDSM  Des Moines-SAT San Antonio
9h 30m1 stop Las Vegas Harry Reid Intl
Southwest Logo
6:00 am - 2:15 pmSAT  San Antonio-DSM Des Moines
8h 15m1 stop Denver Intl
$275Southwest
Wed, Oct 28 - Wed, Nov 4
American Airlines Logo
7:37 pm - 12:04 amDSM  Des Moines-SAT San Antonio
4h 27m1 stop Dallas/Fort Worth
American Airlines Logo
6:40 pm - 12:18 amSAT  San Antonio-DSM Des Moines
5h 38m1 stop Chicago O'Hare Intl
$288American Airlines
Thu, Nov 5 - Tue, Nov 10
American Airlines Logo
4:12 pm - 10:57 pmDSM  Des Moines-SAT San Antonio
6h 45m1 stop Dallas/Fort Worth
American Airlines Logo
7:06 pm - 11:05 pmSAT  San Antonio-DSM Des Moines
3h 59m1 stop Dallas/Fort Worth
$288American Airlines
Tue, Oct 27 - Mon, Nov 2
Frontier Logo
8:30 pm - 7:25 pmDSM  Des Moines-SAT San Antonio
22h 55m1 stop Denver Intl
Frontier Logo
8:20 pm - 7:35 pmSAT  San Antonio-DSM Des Moines
23h 15m1 stop Denver Intl
$290Frontier
Fri, Oct 30 - Thu, Nov 5
Multiple Airlines Logo
8:30 pm - 7:25 pmDSM  Des Moines-SAT San Antonio
22h 55m1 stop Denver Intl
Multiple Airlines Logo
8:20 pm - 1:55 pmSAT  San Antonio-DSM Des Moines
17h 35m2 stops Denver Intl Las Vegas Harry Reid Intl
$303Multiple Airlines
Fri, Oct 30 - Tue, Nov 3

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Delta flights from Des Moines to San Antonio

Our best Delta deals on Des Moines to San Antonio flight tickets
Delta
Oct 27
DSM11:27 amDes Moines
5h 47m
1 stop
SAT5:14 pmSan Antonio
Nov 4
SAT6:50 amSan Antonio
8h 26m
1 stop
DSM3:16 pmDes Moines
$269
Delta
Oct 27
DSM10:57 amDes Moines
6h 37m
1 stop
SAT5:34 pmSan Antonio
Nov 2
SAT6:50 amSan Antonio
8h 26m
1 stop
DSM3:16 pmDes Moines
$288
Delta
Nov 10
DSM2:48 pmDes Moines
6h 38m
1 stop
SAT9:26 pmSan Antonio
Nov 18
SAT2:33 pmSan Antonio
4h 42m
1 stop
DSM7:15 pmDes Moines
$291

Frontier flights from Des Moines to San Antonio

Our best Frontier deals on Des Moines to San Antonio flight tickets
Frontier
Oct 30
DSM8:30 pmDes Moines
22h 55m
1 stop
SAT7:25 pmSan Antonio
Nov 5
SAT8:20 pmSan Antonio
23h 15m
1 stop
DSM7:35 pmDes Moines
$290
Frontier
Oct 30
DSM8:30 pmDes Moines
22h 55m
1 stop
SAT7:25 pmSan Antonio
Nov 5
SAT10:29 pmSan Antonio
21h 06m
2 stops
DSM7:35 pmDes Moines
$333
Frontier
Oct 1
DSM11:29 amDes Moines
7h 56m
1 stop
SAT7:25 pmSan Antonio
Oct 11
SAT8:21 pmSan Antonio
23h 09m
1 stop
DSM7:30 pmDes Moines
$348

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Tue 11/10

2:48 pm-9:26 pm

1 stop6h 38m

San Antonio

Wed 11/18

2:33 pm-7:15 pm

1 stop4h 42m

$269

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Tue 11/10

11:36 am-7:48 pm

1 stop8h 12m

San Antonio

Wed 11/18

5:30 am-10:51 am

1 stop5h 21m

$269

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Sat 10/17

3:02 pm-9:31 pm

1 stop6h 29m

San Antonio

Sat 10/24

5:30 am-12:31 pm

1 stop7h 01m

$269

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Sat 10/17

5:22 pm-11:58 pm

1 stop6h 36m

San Antonio

Sat 10/24

5:30 am-12:42 pm

2 stops7h 12m

$274

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Wed 10/28

7:05 am-2:00 pm

1 stop6h 55m

San Antonio

Wed 11/4

6:45 am-2:15 pm

2 stops7h 30m

$275

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Wed 10/28

12:10 pm-9:40 pm

1 stop9h 30m

San Antonio

Wed 11/4

6:00 am-2:15 pm

1 stop8h 15m

$275
Quickest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 11/5

7:37 pm-12:04 am

1 stop4h 27m

San Antonio

Tue 11/10

6:40 pm-12:18 am

1 stop5h 38m

$288

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Tue 10/27

4:12 pm-10:57 pm

1 stop6h 45m

San Antonio

Mon 11/2

7:06 pm-11:05 pm

1 stop3h 59m

$288

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Fri 10/30

8:30 pm-7:25 pm

1 stop22h 55m

San Antonio

Thu 11/5

8:20 pm-7:35 pm

1 stop23h 15m

$290

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Fri 10/30

8:30 pm-7:25 pm

1 stop22h 55m

San Antonio

Tue 11/3

8:20 pm-1:55 pm

2 stops17h 35m

$303

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Antonio?

Prices are currently low for flights on this route.

Typical prices usually range from $375 to $400.
The lowest price recently found on this route was $269.

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of November, then book flights to San Antonio from Des Moines during April instead. Flights to San Antonio in April, while not as cheap as those in November, still average around $386.

How have Des Moines to San Antonio flight prices changed over time?

As of September 2026, prices for Des Moines to San Antonio flights are approximately 13% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Best Price Found

$135

Fastest flight time

5h 06m

Direct flights

None
The best one-way flight to San Antonio from Des Moines in the past 72 hours is $135. The best round-trip flight deal from Des Moines to San Antonio found on momondo in the last 72 hours is $269.
The fastest flight from Des Moines to San Antonio takes 5h 06m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

Frequently asked questions about flying from Des Moines to San Antonio

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 5h 06m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $213Free CancellationRating
7.8
8,586 reviews
Search Delta flights
American AirlinesPriceFrom $316Free CancellationRating
7.1
12,080 reviews
Search American Airlines flights
United AirlinesPriceFrom $316Free CancellationRating
7.4
10,226 reviews
Search United Airlines flights
SouthwestPriceFrom $359Free CancellationRating
8.0
4,192 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Pleasanton
Boerne
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your San Antonio trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sun 10/18
Sun 10/25
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States