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Cheap flights from Des Moines to San Antonio from $163

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:26 am - 10:47 amDSM  Des Moines-SAT San Antonio
5h 21m1 stop Dallas/Fort Worth
American Airlines Logo
8:15 am - 2:44 pmSAT  San Antonio-DSM Des Moines
6h 29m1 stop Dallas/Fort Worth
$347American Airlines
Sat, Dec 5 - Sat, Dec 12
American Airlines Logo
7:16 pm - 12:06 amDSM  Des Moines-SAT San Antonio
4h 50m1 stop Dallas/Fort Worth
American Airlines Logo
6:36 pm - 12:33 amSAT  San Antonio-DSM Des Moines
5h 57m1 stop Chicago O'Hare Intl
$352American Airlines
Tue, Dec 1 - Fri, Dec 4
United Airlines Logo
11:27 am - 7:20 pmDSM  Des Moines-SAT San Antonio
7h 53m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
4:10 pm - 10:21 pmSAT  San Antonio-DSM Des Moines
6h 11m1 stop Houston George Bush Intcntl
$352United Airlines
Sat, Dec 5 - Sat, Dec 12
Southwest Logo
7:15 pm - 12:30 amDSM  Des Moines-SAT San Antonio
5h 15m1 stop Chicago Midway
Southwest Logo
7:55 am - 5:45 pmSAT  San Antonio-DSM Des Moines
9h 50m1 stop Las Vegas Harry Reid Intl
$362Southwest
Wed, Dec 30 - Thu, Jan 7
Southwest Logo
7:15 pm - 12:30 amDSM  Des Moines-SAT San Antonio
5h 15m1 stop Chicago Midway
Southwest Logo
12:55 pm - 8:40 pmSAT  San Antonio-DSM Des Moines
7h 45m2 stops Houston Hobby Denver Intl
$367Southwest
Wed, Dec 30 - Thu, Jan 7
United Airlines Logo
1:23 pm - 9:26 pmDSM  Des Moines-SAT San Antonio
8h 03m2 stops Denver Intl Houston George Bush Intcntl
United Airlines Logo
5:10 pm - 11:15 pmSAT  San Antonio-DSM Des Moines
6h 05m1 stop Chicago O'Hare Intl
$417United Airlines
Sun, Dec 13 - Mon, Dec 14
Delta Logo
2:58 pm - 10:19 pmDSM  Des Moines-SAT San Antonio
7h 21m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:16 am - 10:53 amSAT  San Antonio-DSM Des Moines
5h 37m1 stop Atlanta Hartsfield-Jackson
$432Delta
Fri, Dec 4 - Sun, Dec 6
Frontier Logo
8:28 pm - 7:33 pmDSM  Des Moines-SAT San Antonio
23h 05m1 stop Denver Intl
Frontier Logo
8:28 pm - 7:33 pmSAT  San Antonio-DSM Des Moines
23h 05m1 stop Denver Intl
$438Frontier
Sun, Nov 22 - Wed, Nov 25
Frontier Logo
8:28 pm - 7:33 pmDSM  Des Moines-SAT San Antonio
23h 05m1 stop Denver Intl
Frontier Logo
8:28 pm - 7:33 pmSAT  San Antonio-DSM Des Moines
23h 05m1 stop Denver Intl
$441Frontier
Sun, Nov 22 - Wed, Nov 25
Delta Logo
5:45 am - 11:26 amDSM  Des Moines-SAT San Antonio
5h 41m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:25 pm - 10:29 pmSAT  San Antonio-DSM Des Moines
6h 04m1 stop Atlanta Hartsfield-Jackson
$447Delta
Thu, Apr 15 - Mon, Apr 19

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American Airlines flights from Des Moines to San Antonio

Our best American Airlines deals on Des Moines to San Antonio flight tickets
American Airlines
Dec 5
DSM5:26 amDes Moines
5h 21m
1 stop
SAT10:47 amSan Antonio
Dec 12
SAT8:15 amSan Antonio
6h 29m
1 stop
DSM2:44 pmDes Moines
$347
American Airlines
Dec 1
DSM7:16 pmDes Moines
4h 50m
1 stop
SAT12:06 amSan Antonio
Dec 4
SAT6:36 pmSan Antonio
5h 57m
1 stop
DSM12:33 amDes Moines
$352
American Airlines
Dec 1
DSM7:16 pmDes Moines
4h 50m
1 stop
SAT12:06 amSan Antonio
Dec 3
SAT5:45 pmSan Antonio
5h 20m
1 stop
DSM11:05 pmDes Moines
$362

United Airlines flights from Des Moines to San Antonio

Our best United Airlines deals on Des Moines to San Antonio flight tickets
United Airlines
Dec 13
DSM1:23 pmDes Moines
8h 03m
2 stops
SAT9:26 pmSan Antonio
Dec 14
SAT5:10 pmSan Antonio
6h 05m
1 stop
DSM11:15 pmDes Moines
$417
United Airlines
Dec 1
DSM9:30 amDes Moines
8h 05m
2 stops
SAT5:35 pmSan Antonio
Dec 4
SAT5:45 pmSan Antonio
4h 36m
1 stop
DSM10:21 pmDes Moines
$424
United Airlines
Dec 14
DSM8:00 amDes Moines
5h 06m
1 stop
SAT1:06 pmSan Antonio
Dec 16
SAT8:45 amSan Antonio
7h 28m
1 stop
DSM4:13 pmDes Moines
$425

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Sat 12/5

5:26 am-10:47 am

1 stop5h 21m

San Antonio

Sat 12/12

8:15 am-2:44 pm

1 stop6h 29m

$347
Quickest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Tue 12/1

7:16 pm-12:06 am

1 stop4h 50m

San Antonio

Fri 12/4

6:36 pm-12:33 am

1 stop5h 57m

$352

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Sat 12/5

11:27 am-7:20 pm

2 stops7h 53m

San Antonio

Sat 12/12

4:10 pm-10:21 pm

1 stop6h 11m

$352

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Wed 12/30

7:15 pm-12:30 am

1 stop5h 15m

San Antonio

Thu 1/7

7:55 am-5:45 pm

1 stop9h 50m

$362

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Wed 12/30

7:15 pm-12:30 am

1 stop5h 15m

San Antonio

Thu 1/7

12:55 pm-8:40 pm

2 stops7h 45m

$367

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Sun 12/13

1:23 pm-9:26 pm

2 stops8h 03m

San Antonio

Mon 12/14

5:10 pm-11:15 pm

1 stop6h 05m

$417

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Fri 12/4

2:58 pm-10:19 pm

1 stop7h 21m

San Antonio

Sun 12/6

5:16 am-10:53 am

1 stop5h 37m

$432

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Sun 11/22

8:28 pm-7:33 pm

1 stop23h 05m

San Antonio

Wed 11/25

8:28 pm-7:33 pm

1 stop23h 05m

$438

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Sun 11/22

8:28 pm-7:33 pm

1 stop23h 05m

San Antonio

Wed 11/25

8:28 pm-7:33 pm

1 stop23h 05m

$441

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 4/15

5:45 am-11:26 am

1 stop5h 41m

San Antonio

Mon 4/19

4:25 pm-10:29 pm

1 stop6h 04m

$447

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of November, then book flights to San Antonio from Des Moines during April instead. Flights to San Antonio in April, while not as cheap as those in November, still average around $386.

How far in advance should I book a flight from Des Moines to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $451 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $322 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of November 2026, prices for Des Moines to San Antonio flights are approximately 47% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Best Price Found

$163

Fastest flight time

5h 05m

Direct flights

None
The best one-way flight to San Antonio from Des Moines in the past 72 hours is $163. The best round-trip flight deal from Des Moines to San Antonio found on momondo in the last 72 hours is $347.
The fastest flight from Des Moines to San Antonio takes 5h 05m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

Frequently asked questions about flying from Des Moines to San Antonio

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 5h 05m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $268Free CancellationRating
7.8
8,700 reviews
Search Delta flights
United AirlinesPriceFrom $316Free CancellationRating
7.3
10,471 reviews
Search United Airlines flights
American AirlinesPriceFrom $316Free CancellationRating
7.0
12,224 reviews
Search American Airlines flights
SouthwestPriceFrom $324Free CancellationRating
8.0
4,219 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Pleasanton
Boerne
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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