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Cheap flights from Des Moines to San Antonio from $102

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 4/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
2:04 pm - 3:09 pm
DSM
-
SAT
25h 05m
1 stop
Frontier Logo
2:59 pm - 1:09 pm
SAT
-
DSM
22h 10m
1 stop
$246Frontier
Fri, Apr 24 - Sun, Apr 26
Frontier Logo
2:04 pm - 3:09 pm
DSM
-
SAT
25h 05m
1 stop
Frontier Logo
2:59 pm - 1:09 pm
SAT
-
DSM
22h 10m
1 stop
$267Frontier
Fri, Apr 24 - Sun, Apr 26
Frontier Logo
2:16 pm - 6:59 pm
DSM
-
SAT
28h 43m
1 stop
Frontier Logo
8:59 pm - 1:31 pm
SAT
-
DSM
16h 32m
2 stops
$272Frontier
Wed, Jun 3 - Sun, Jun 7
Multiple Airlines Logo
2:16 pm - 6:59 pm
DSM
-
SAT
28h 43m
1 stop
Multiple Airlines Logo
5:26 pm - 11:27 pm
SAT
-
DSM
30h 01m
1 stop
$289Multiple Airlines
Wed, Jun 3 - Sun, Jun 7
Multiple Airlines Logo
2:16 pm - 6:59 pm
DSM
-
SAT
28h 43m
1 stop
Multiple Airlines Logo
7:54 pm - 11:22 am
SAT
-
DSM
39h 28m
2 stops
$290Multiple Airlines
Fri, May 29 - Wed, Jun 3
Multiple Airlines Logo
7:45 am - 4:16 pm
DSM
-
SAT
8h 31m
1 stop
Multiple Airlines Logo
7:54 pm - 1:20 pm
SAT
-
DSM
41h 26m
2 stops
$299Multiple Airlines
Thu, May 14 - Tue, May 19
Frontier Logo
2:04 pm - 3:09 pm
DSM
-
SAT
25h 05m
1 stop
Frontier Logo
2:59 pm - 1:09 pm
SAT
-
DSM
22h 10m
1 stop
$301Frontier
Fri, Apr 24 - Sun, Apr 26
Multiple Airlines Logo
4:41 pm - 4:16 pm
DSM
-
SAT
23h 35m
2 stops
Multiple Airlines Logo
5:26 pm - 11:24 pm
SAT
-
DSM
29h 58m
1 stop
$315Multiple Airlines
Sun, May 24 - Thu, May 28
Multiple Airlines Logo
7:45 am - 4:16 pm
DSM
-
SAT
8h 31m
1 stop
Multiple Airlines Logo
8:59 pm - 12:59 pm
SAT
-
DSM
16h 00m
1 stop
$319Multiple Airlines
Thu, May 14 - Tue, May 19
Frontier Logo
2:16 pm - 6:59 pm
DSM
-
SAT
28h 43m
1 stop
Frontier Logo
7:54 pm - 1:31 pm
SAT
-
DSM
17h 37m
1 stop
$320Frontier
Fri, May 8 - Thu, May 14

Delta flights from Des Moines to San Antonio

Our best Delta deals on Des Moines to San Antonio flight tickets
Delta
Jun 17
DSM6:39 pmDes Moines
5h 51m
1 stop
SAT12:30 amSan Antonio
Jun 23
SAT5:25 amSan Antonio
8h 36m
1 stop
DSM2:01 pmDes Moines
$335
Delta
May 2
DSM11:51 amDes Moines
6h 08m
1 stop
SAT5:59 pmSan Antonio
May 5
SAT2:00 pmSan Antonio
8h 34m
1 stop
DSM10:34 pmDes Moines
$346
Delta
Apr 30
DSM7:00 amDes Moines
4h 49m
1 stop
SAT11:49 amSan Antonio
May 5
SAT8:00 amSan Antonio
5h 55m
1 stop
DSM1:55 pmDes Moines
$350

Frontier flights from Des Moines to San Antonio

Our best Frontier deals on Des Moines to San Antonio flight tickets
Frontier
Apr 24
DSM2:04 pmDes Moines
25h 05m
1 stop
SAT3:09 pmSan Antonio
Apr 26
SAT2:59 pmSan Antonio
22h 10m
1 stop
DSM1:09 pmDes Moines
$246
Frontier
Apr 24
DSM2:04 pmDes Moines
25h 05m
1 stop
SAT3:09 pmSan Antonio
Apr 26
SAT2:59 pmSan Antonio
22h 10m
1 stop
DSM1:09 pmDes Moines
$267
Frontier
Jun 3
DSM2:16 pmDes Moines
28h 43m
1 stop
SAT6:59 pmSan Antonio
Jun 7
SAT8:59 pmSan Antonio
16h 32m
2 stops
DSM1:31 pmDes Moines
$272

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 11, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 4/24

2:04 pm-3:09 pm

1 stop25h 05m

San Antonio

Sun 4/26

2:59 pm-1:09 pm

1 stop22h 10m

$246

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 4/24

2:04 pm-3:09 pm

1 stop25h 05m

San Antonio

Sun 4/26

2:59 pm-1:09 pm

1 stop22h 10m

$267

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 6/3

2:16 pm-6:59 pm

1 stop28h 43m

San Antonio

Sun 6/7

8:59 pm-1:31 pm

2 stops16h 32m

$272

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 6/3

2:16 pm-6:59 pm

1 stop28h 43m

San Antonio

Sun 6/7

5:26 pm-11:27 pm

1 stop30h 01m

$289

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 5/29

2:16 pm-6:59 pm

1 stop28h 43m

San Antonio

Wed 6/3

7:54 pm-11:22 am

2 stops39h 28m

$290

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 5/14

7:45 am-4:16 pm

1 stop8h 31m

San Antonio

Tue 5/19

7:54 pm-1:20 pm

2 stops41h 26m

$299

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 4/24

2:04 pm-3:09 pm

1 stop25h 05m

San Antonio

Sun 4/26

2:59 pm-1:09 pm

1 stop22h 10m

$301

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sun 5/24

4:41 pm-4:16 pm

2 stops23h 35m

San Antonio

Thu 5/28

5:26 pm-11:24 pm

1 stop29h 58m

$315
Quickest round-trip

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 5/14

7:45 am-4:16 pm

1 stop8h 31m

San Antonio

Tue 5/19

8:59 pm-12:59 pm

1 stop16h 00m

$319

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 5/8

2:16 pm-6:59 pm

1 stop28h 43m

San Antonio

Thu 5/14

7:54 pm-1:31 pm

1 stop17h 37m

$320

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Antonio?

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of August, then book flights to San Antonio from Des Moines during July instead. Flights to San Antonio in July, while not as cheap as those in August, still average around $334.

How far in advance should I book a flight to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $405 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $290 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of April 2026, prices for Des Moines to San Antonio flights are approximately 141% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Fastest flight time

4h 45m

Direct flights

None
The fastest flight from Des Moines to San Antonio takes 4h 45m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

Frequently asked questions about flying from Des Moines to San Antonio

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 45m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $266Free CancellationRating
7.1
11,573 reviews
Search American Airlines flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
9,570 reviews
Search United Airlines flights
SouthwestPriceFrom $327Free CancellationRating
8.0
4,335 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Pleasanton
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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