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Cheap flights from Des Moines to San Antonio from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 2/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:30 am - 8:46 pm
DSM
-
SAT
12h 16m1 stop
Multiple Airlines Logo
4:13 pm - 6:41 pm
SAT
-
DSM
26h 28m1 stop
$179Multiple Airlines
Mon, Feb 2 - Wed, Feb 11
American Airlines Logo
4:00 pm - 9:52 pm
DSM
-
SAT
5h 52m1 stop
American Airlines Logo
10:32 am - 5:06 pm
SAT
-
DSM
6h 34m1 stop
$181American Airlines
Wed, Jan 14 - Wed, Jan 21
Multiple Airlines Logo
2:58 pm - 9:40 am
DSM
-
SAT
18h 42m1 stop
Multiple Airlines Logo
10:35 am - 10:46 pm
SAT
-
DSM
12h 11m1 stop
$200Multiple Airlines
Sun, Jan 11 - Thu, Jan 22
American Airlines Logo
4:25 pm - 11:58 pm
DSM
-
SAT
7h 33m1 stop
American Airlines Logo
6:14 am - 10:50 am
SAT
-
DSM
4h 36m1 stop
$207American Airlines
Mon, Feb 2 - Wed, Feb 11
Delta Logo
11:26 am - 5:15 pm
DSM
-
SAT
5h 49m1 stop
Delta Logo
5:20 am - 10:41 am
SAT
-
DSM
5h 21m1 stop
$217Delta
Tue, Jan 13 - Wed, Jan 21
Southwest Logo
8:35 am - 2:00 pm
DSM
-
SAT
5h 25m1 stop
Southwest Logo
12:25 pm - 7:20 pm
SAT
-
DSM
6h 55m2 stops
$220Southwest
Wed, Jan 14 - Wed, Jan 21
Delta Logo
4:21 pm - 9:34 pm
DSM
-
SAT
5h 13m1 stop
Delta Logo
5:20 am - 10:41 am
SAT
-
DSM
5h 21m1 stop
$225Delta
Wed, Jan 14 - Thu, Jan 22
Multiple Airlines Logo
5:58 pm - 8:14 am
DSM
-
SAT
14h 16m1 stop
Multiple Airlines Logo
10:35 am - 10:46 pm
SAT
-
DSM
12h 11m1 stop
$229Multiple Airlines
Sat, Jan 17 - Thu, Jan 22
Multiple Airlines Logo
2:58 pm - 9:40 am
DSM
-
SAT
18h 42m1 stop
Multiple Airlines Logo
8:24 pm - 10:09 pm
SAT
-
DSM
49h 45m2 stops
$230Multiple Airlines
Sun, Jan 11 - Fri, Jan 23
Multiple Airlines Logo
4:30 pm - 11:52 pm
DSM
-
SAT
55h 22m2 stops
Multiple Airlines Logo
10:35 am - 10:46 pm
SAT
-
DSM
12h 11m1 stop
$231Multiple Airlines
Sun, Jan 11 - Thu, Jan 22

American Airlines flights from Des Moines to San Antonio

Our best American Airlines deals on Des Moines to San Antonio flight tickets
American Airlines
Jan 14
DSM4:00 pmDes Moines
5h 52m
1 stop
SAT9:52 pmSan Antonio
Jan 21
SAT10:32 amSan Antonio
6h 34m
1 stop
DSM5:06 pmDes Moines
$181
Find similar
American Airlines
Feb 2
DSM4:25 pmDes Moines
7h 33m
1 stop
SAT11:58 pmSan Antonio
Feb 11
SAT6:14 amSan Antonio
4h 36m
1 stop
DSM10:50 amDes Moines
$207
Find similar
American Airlines
Feb 21
DSM10:09 amDes Moines
7h 52m
2 stops
SAT6:01 pmSan Antonio
Feb 24
SAT6:00 amSan Antonio
4h 47m
1 stop
DSM10:47 amDes Moines
$236
Find similar

Delta flights from Des Moines to San Antonio

Our best Delta deals on Des Moines to San Antonio flight tickets
Delta
Jan 13
DSM11:26 amDes Moines
5h 49m
1 stop
SAT5:15 pmSan Antonio
Jan 21
SAT5:20 amSan Antonio
5h 21m
1 stop
DSM10:41 amDes Moines
$217
Find similar
Delta
Jan 17
DSM1:03 pmDes Moines
7h 40m
1 stop
SAT8:43 pmSan Antonio
Jan 24
SAT6:30 amSan Antonio
5h 45m
1 stop
DSM12:15 pmDes Moines
$233
Find similar
Delta
Jan 13
DSM11:26 amDes Moines
5h 49m
1 stop
SAT5:15 pmSan Antonio
Jan 23
SAT5:20 amSan Antonio
5h 21m
1 stop
DSM10:41 amDes Moines
$251
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Mon 2/2

8:30 am-8:46 pm

1 stop12h 16m

San Antonio

Wed 2/11

4:13 pm-6:41 pm

1 stop26h 28m

$179

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 1/14

4:00 pm-9:52 pm

1 stop5h 52m

San Antonio

Wed 1/21

10:32 am-5:06 pm

1 stop6h 34m

$181

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sun 1/11

2:58 pm-9:40 am

1 stop18h 42m

San Antonio

Thu 1/22

10:35 am-10:46 pm

1 stop12h 11m

$200

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Mon 2/2

4:25 pm-11:58 pm

1 stop7h 33m

San Antonio

Wed 2/11

6:14 am-10:50 am

1 stop4h 36m

$207

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Tue 1/13

11:26 am-5:15 pm

1 stop5h 49m

San Antonio

Wed 1/21

5:20 am-10:41 am

1 stop5h 21m

$217

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 1/14

8:35 am-2:00 pm

1 stop5h 25m

San Antonio

Wed 1/21

12:25 pm-7:20 pm

2 stops6h 55m

$220

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 1/14

4:21 pm-9:34 pm

1 stop5h 13m

San Antonio

Thu 1/22

5:20 am-10:41 am

1 stop5h 21m

$225

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sat 1/17

5:58 pm-8:14 am

1 stop14h 16m

San Antonio

Thu 1/22

10:35 am-10:46 pm

1 stop12h 11m

$229

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sun 1/11

2:58 pm-9:40 am

1 stop18h 42m

San Antonio

Fri 1/23

8:24 pm-10:09 pm

2 stops49h 45m

$230

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sun 1/11

4:30 pm-11:52 pm

2 stops55h 22m

San Antonio

Thu 1/22

10:35 am-10:46 pm

1 stop12h 11m

$231

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of August, then book flights to San Antonio from Des Moines during July instead. Flights to San Antonio in July, while not as cheap as those in August, still average around $334.

What is the cheapest day to depart on your flight to San Antonio?

The cheapest day to depart on your flight to San Antonio is on a Wednesday when prices can be found for as low as $366. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to San Antonio on Monday is $411.

What is the cheapest time of day to depart on your flight to San Antonio?

According to our data, the cheapest time of day to fly to San Antonio is in the evening. momondo users have found flights departing from Des Moines to San Antonio in the evening for as low as $301. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to San Antonio are more costly in the morning, with an average ticket price of $402. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $404 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $335 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of December 2025, prices for Des Moines to San Antonio flights are approximately 53% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Fastest flight time

5h 16m

Direct flights

None
The fastest flight from Des Moines to San Antonio takes 5h 16m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 58m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $274Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights
DeltaPriceFrom $283Free CancellationRating
7.9
8,011 reviews
Search Delta flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
9,066 reviews
Search United Airlines flights
SouthwestPriceFrom $327Free CancellationRating
8.0
4,250 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Schertz
Pleasanton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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