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Cheap flights from Des Moines to San Antonio from $159

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 9/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Southwest Logo
6:10 am - 11:00 amDSM-SAT
4h 50m1 stop
Southwest Logo
5:35 am - 12:25 pmSAT-DSM
6h 50m1 stop
$159Southwest
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Sat, Sep 6 - Sat, Sep 13
Southwest Logo
6:10 am - 4:40 pmDSM-SAT
10h 30m2 stops
Southwest Logo
5:35 am - 12:25 pmSAT-DSM
6h 50m1 stop
$164Southwest
Find Deal
Sat, Sep 6 - Sat, Sep 13
American Airlines Logo
5:05 am - 9:19 amDSM-SAT
4h 14m1 stop
American Airlines Logo
5:06 am - 10:03 amSAT-DSM
4h 57m1 stop
$173American Airlines
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Thu, Oct 30 - Tue, Nov 4
American Airlines Logo
7:34 am - 4:30 pmDSM-SAT
8h 56m2 stops
American Airlines Logo
7:30 am - 4:48 pmSAT-DSM
9h 18m1 stop
$178American Airlines
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Sat, Aug 23 - Mon, Aug 25
Frontier Logo
7:33 pm - 6:02 pmDSM-SAT
22h 29m1 stop
Frontier Logo
8:18 pm - 2:23 pmSAT-DSM
18h 05m1 stop
$211Frontier
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Fri, Aug 8 - Sun, Aug 24
United Airlines Logo
2:58 pm - 7:52 pmDSM-SAT
4h 54m1 stop
United Airlines Logo
4:22 pm - 11:41 pmSAT-DSM
7h 19m2 stops
$228United Airlines
Find Deal
Fri, Aug 22 - Mon, Aug 25
Delta Logo
2:05 pm - 10:19 pmDSM-SAT
8h 14m1 stop
Delta Logo
5:29 am - 10:40 amSAT-DSM
5h 11m1 stop
$237Delta
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Fri, Oct 3 - Sun, Oct 5
Frontier Logo
2:25 pm - 2:27 pmDSM-SAT
24h 02m1 stop
Frontier Logo
8:20 pm - 1:40 pmSAT-DSM
17h 20m1 stop
$250Frontier
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Fri, Sep 12 - Sun, Sep 14
Delta Logo
5:59 pm - 12:14 amDSM-SAT
6h 15m1 stop
Delta Logo
1:40 pm - 8:57 pmSAT-DSM
7h 17m1 stop
$267Delta
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Sat, Aug 2 - Wed, Aug 6
United Airlines Logo
6:05 am - 10:43 amDSM-SAT
4h 38m1 stop
United Airlines Logo
5:30 am - 4:12 pmSAT-DSM
10h 42m2 stops
$298United Airlines
Find Deal
Thu, Oct 30 - Tue, Nov 4

American Airlines flights from Des Moines to San Antonio

Our best American Airlines deals on Des Moines to San Antonio flight tickets
American Airlines
Oct 30
DSM5:05 amDes Moines
4h 14m
1 stop
SAT9:19 amSan Antonio
Nov 4
SAT5:06 amSan Antonio
4h 57m
1 stop
DSM10:03 amDes Moines
$173
Find similar
American Airlines
Aug 23
DSM7:34 amDes Moines
8h 56m
2 stops
SAT4:30 pmSan Antonio
Aug 25
SAT7:30 amSan Antonio
9h 18m
1 stop
DSM4:48 pmDes Moines
$178
Find similar
American Airlines
Aug 22
DSM5:12 amDes Moines
6h 26m
1 stop
SAT11:38 amSan Antonio
Aug 25
SAT7:30 amSan Antonio
9h 18m
1 stop
DSM4:48 pmDes Moines
$198
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Frontier flights from Des Moines to San Antonio

Our best Frontier deals on Des Moines to San Antonio flight tickets
Frontier
Aug 8
DSM7:33 pmDes Moines
22h 29m
1 stop
SAT6:02 pmSan Antonio
Aug 24
SAT8:18 pmSan Antonio
18h 05m
1 stop
DSM2:23 pmDes Moines
$211
Find similar
Frontier
Sep 12
DSM2:25 pmDes Moines
24h 02m
1 stop
SAT2:27 pmSan Antonio
Sep 14
SAT8:20 pmSan Antonio
17h 20m
1 stop
DSM1:40 pmDes Moines
$250
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of August, then book flights to San Antonio from Des Moines during July instead. Flights to San Antonio in July, while not as cheap as those in August, still average around $328.

What is the cheapest day to depart on your flight to San Antonio?

The cheapest day to depart on your flight to San Antonio is on a Wednesday when prices can be found for as low as $366. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to San Antonio on Monday is $411.

What is the cheapest time of day to depart on your flight to San Antonio?

According to our data, the cheapest time of day to fly to San Antonio is in the evening. momondo users have found flights departing from Des Moines to San Antonio in the evening for as low as $301. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to San Antonio are more costly in the morning, with an average ticket price of $402. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $388 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $304 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of July 2025, prices for Des Moines to San Antonio flights are approximately 56% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Best Price Found

$159

Fastest flight time

4h 13m

Direct flights

None

Airports in San Antonio

1 airport
The best flight deal from Des Moines to San Antonio found on momondo in the last 72 hours is $159
The fastest flight from Des Moines to San Antonio takes 4h 13m
There are no direct flights from Des Moines to San Antonio. Popular non-direct route for this connection is Des Moines Airport - San Antonio Airport.
There is 1 airport near San Antonio: San Antonio (SAT)
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  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 13m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $286Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $289Free CancellationRating
8.0
7,951 reviews
Search Delta flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
8,846 reviews
Search United Airlines flights
SouthwestPriceFrom $327Free CancellationRating
8.0
4,249 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Schertz
Pleasanton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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