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Cheap flights from Des Moines to San Antonio from $159

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:28 pm - 7:33 pmDSM  Des Moines-SAT San Antonio
23h 05m1 stop Denver Intl
Frontier Logo
6:44 pm - 7:40 pmSAT  San Antonio-DSM Des Moines
24h 56m1 stop Denver Intl
$276Frontier
Thu, Nov 26 - Wed, Dec 2
Frontier Logo
8:30 pm - 7:25 pmDSM  Des Moines-SAT San Antonio
22h 55m1 stop Denver Intl
Frontier Logo
8:20 pm - 7:35 pmSAT  San Antonio-DSM Des Moines
23h 15m1 stop Denver Intl
$279Frontier
Fri, Nov 13 - Sun, Nov 15
American Airlines Logo
7:37 pm - 12:04 amDSM  Des Moines-SAT San Antonio
4h 27m1 stop Dallas/Fort Worth
American Airlines Logo
7:06 pm - 11:05 pmSAT  San Antonio-DSM Des Moines
3h 59m1 stop Dallas/Fort Worth
$325American Airlines
Mon, Nov 9 - Mon, Nov 16
American Airlines Logo
7:16 pm - 12:06 amDSM  Des Moines-SAT San Antonio
4h 50m1 stop Dallas/Fort Worth
American Airlines Logo
2:03 pm - 6:27 pmSAT  San Antonio-DSM Des Moines
4h 24m1 stop Dallas/Fort Worth
$325American Airlines
Fri, Nov 27 - Tue, Dec 1
United Airlines Logo
8:00 am - 3:38 pmDSM  Des Moines-SAT San Antonio
7h 38m1 stop Houston George Bush Intcntl
United Airlines Logo
4:19 pm - 10:30 pmSAT  San Antonio-DSM Des Moines
6h 11m1 stop Houston George Bush Intcntl
$325United Airlines
Tue, Nov 10 - Tue, Nov 17
United Airlines Logo
5:30 am - 12:46 pmDSM  Des Moines-SAT San Antonio
7h 16m1 stop Denver Intl
United Airlines Logo
4:19 pm - 10:30 pmSAT  San Antonio-DSM Des Moines
6h 11m1 stop Houston George Bush Intcntl
$325United Airlines
Wed, Nov 11 - Wed, Nov 18
Delta Logo
6:52 pm - 12:33 amDSM  Des Moines-SAT San Antonio
5h 41m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:30 am - 2:13 pmSAT  San Antonio-DSM Des Moines
7h 43m1 stop Atlanta Hartsfield-Jackson
$325Delta
Tue, Nov 10 - Wed, Nov 18
Delta Logo
11:01 am - 5:38 pmDSM  Des Moines-SAT San Antonio
6h 37m1 stop Minneapolis St Paul
Delta Logo
6:16 am - 2:13 pmSAT  San Antonio-DSM Des Moines
7h 57m1 stop Atlanta Hartsfield-Jackson
$325Delta
Tue, Dec 8 - Fri, Dec 11
Southwest Logo
3:30 pm - 11:40 pmDSM  Des Moines-SAT San Antonio
8h 10m1 stop Chicago Midway
Southwest Logo
5:40 am - 12:25 pmSAT  San Antonio-DSM Des Moines
6h 45m1 stop Las Vegas Harry Reid Intl
$325Southwest
Thu, Dec 24 - Sat, Jan 9
Southwest Logo
3:30 pm - 11:45 pmDSM  Des Moines-SAT San Antonio
8h 15m1 stop Chicago Midway
Southwest Logo
2:40 pm - 10:00 pmSAT  San Antonio-DSM Des Moines
7h 20m1 stop Chicago Midway
$325Southwest
Thu, Dec 3 - Mon, Dec 7

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Frontier flights from Des Moines to San Antonio

Our best Frontier deals on Des Moines to San Antonio flight tickets
Frontier
Nov 26
DSM8:28 pmDes Moines
23h 05m
1 stop
SAT7:33 pmSan Antonio
Dec 2
SAT6:44 pmSan Antonio
24h 56m
1 stop
DSM7:40 pmDes Moines
$276
Frontier
Nov 13
DSM8:30 pmDes Moines
22h 55m
1 stop
SAT7:25 pmSan Antonio
Nov 15
SAT8:20 pmSan Antonio
23h 15m
1 stop
DSM7:35 pmDes Moines
$279
Frontier
Dec 20
DSM8:35 pmDes Moines
14h 30m
1 stop
SAT11:05 amSan Antonio
Dec 23
SAT9:21 pmSan Antonio
22h 18m
2 stops
DSM7:39 pmDes Moines
$439

Delta flights from Des Moines to San Antonio

Our best Delta deals on Des Moines to San Antonio flight tickets
Delta
Nov 10
DSM6:52 pmDes Moines
5h 41m
1 stop
SAT12:33 amSan Antonio
Nov 18
SAT6:30 amSan Antonio
7h 43m
1 stop
DSM2:13 pmDes Moines
$325
Delta
Dec 6
DSM2:58 pmDes Moines
7h 21m
1 stop
SAT10:19 pmSan Antonio
Dec 12
SAT6:33 amSan Antonio
5h 22m
1 stop
DSM11:55 amDes Moines
$358
Delta
Nov 12
DSM6:52 pmDes Moines
5h 41m
1 stop
SAT12:33 amSan Antonio
Nov 15
SAT5:25 amSan Antonio
5h 19m
1 stop
DSM10:44 amDes Moines
$412

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

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Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 11/26

8:28 pm-7:33 pm

1 stop23h 05m

San Antonio

Wed 12/2

6:44 pm-7:40 pm

1 stop24h 56m

$276

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Fri 11/13

8:30 pm-7:25 pm

1 stop22h 55m

San Antonio

Sun 11/15

8:20 pm-7:35 pm

1 stop23h 15m

$279
Quickest round-trip

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Mon 11/9

7:37 pm-12:04 am

1 stop4h 27m

San Antonio

Mon 11/16

7:06 pm-11:05 pm

1 stop3h 59m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Fri 11/27

7:16 pm-12:06 am

1 stop4h 50m

San Antonio

Tue 12/1

2:03 pm-6:27 pm

1 stop4h 24m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Tue 11/10

8:00 am-3:38 pm

1 stop7h 38m

San Antonio

Tue 11/17

4:19 pm-10:30 pm

1 stop6h 11m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Wed 11/11

5:30 am-12:46 pm

1 stop7h 16m

San Antonio

Wed 11/18

4:19 pm-10:30 pm

1 stop6h 11m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Tue 11/10

6:52 pm-12:33 am

1 stop5h 41m

San Antonio

Wed 11/18

6:30 am-2:13 pm

1 stop7h 43m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Tue 12/8

11:01 am-5:38 pm

1 stop6h 37m

San Antonio

Fri 12/11

6:16 am-2:13 pm

1 stop7h 57m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 12/24

3:30 pm-11:40 pm

1 stop8h 10m

San Antonio

Sat 1/9

5:40 am-12:25 pm

1 stop6h 45m

$325

Des MoinesSan Antonio

DSM Des Moines - SAT San Antonio

DSMSAT

Des Moines

Thu 12/3

3:30 pm-11:45 pm

1 stop8h 15m

San Antonio

Mon 12/7

2:40 pm-10:00 pm

1 stop7h 20m

$325

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Antonio?

Prices are currently low for flights on this route.

Typical prices usually range from $362 to $416.
The lowest price recently found on this route was $276.

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of December, then book flights to San Antonio from Des Moines during November instead. Flights to San Antonio in November, while not as cheap as those in December, still average around $386.

How far in advance should I book a flight from Des Moines to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $445 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $324 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of October 2026, prices for Des Moines to San Antonio flights are approximately 3% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Best Price Found

$159

Fastest flight time

5h 05m

Direct flights

None
The best one-way flight to San Antonio from Des Moines in the past 72 hours is $159. The best round-trip flight deal from Des Moines to San Antonio found on momondo in the last 72 hours is $276.
The fastest flight from Des Moines to San Antonio takes 5h 05m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

Frequently asked questions about flying from Des Moines to San Antonio

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 5h 05m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $289Free CancellationRating
7.8
8,649 reviews
Search Delta flights
United AirlinesPriceFrom $316Free CancellationRating
7.4
10,359 reviews
Search United Airlines flights
American AirlinesPriceFrom $316Free CancellationRating
7.0
12,164 reviews
Search American Airlines flights
SouthwestPriceFrom $324Free CancellationRating
7.9
4,216 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Pleasanton
Boerne
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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