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Cheap flights from Des Moines to San Antonio from $131

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 8/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
2:19 pm - 7:31 pm
DSM
-
SAT
5h 12m
1 stop
Frontier Logo
8:26 pm - 1:34 pm
SAT
-
DSM
17h 08m
1 stop
$315Frontier
Fri, Sep 4 - Sun, Sep 6
Delta Logo
10:59 am - 5:11 pm
DSM
-
SAT
6h 12m
1 stop
Delta Logo
2:22 pm - 8:59 pm
SAT
-
DSM
6h 37m
1 stop
$317Delta
Thu, Aug 13 - Tue, Aug 18
Multiple Airlines Logo
2:19 pm - 6:54 pm
DSM
-
SAT
28h 35m
1 stop
Multiple Airlines Logo
10:24 pm - 9:00 pm
SAT
-
DSM
22h 36m
1 stop
$320Multiple Airlines
Wed, Aug 12 - Wed, Aug 19
Multiple Airlines Logo
10:06 pm - 8:37 pm
DSM
-
SAT
22h 31m
1 stop
Multiple Airlines Logo
10:24 pm - 9:00 pm
SAT
-
DSM
22h 36m
1 stop
$322Multiple Airlines
Fri, Aug 14 - Wed, Aug 19
Delta Logo
5:40 am - 1:38 pm
DSM
-
SAT
7h 58m
1 stop
Delta Logo
5:30 am - 10:46 am
SAT
-
DSM
5h 16m
1 stop
$327Delta
Sat, Sep 5 - Wed, Sep 9
Delta Logo
5:40 am - 1:38 pm
DSM
-
SAT
7h 58m
1 stop
Delta Logo
5:20 am - 11:21 am
SAT
-
DSM
6h 01m
1 stop
$339Delta
Tue, Sep 1 - Sun, Sep 6
Multiple Airlines Logo
10:06 pm - 8:37 pm
DSM
-
SAT
22h 31m
1 stop
Multiple Airlines Logo
10:24 pm - 6:48 pm
SAT
-
DSM
20h 24m
1 stop
$340Multiple Airlines
Fri, Aug 14 - Thu, Aug 20
Southwest Logo
2:25 pm - 9:25 pm
DSM
-
SAT
7h 00m
1 stop
Southwest Logo
5:00 am - 11:25 am
SAT
-
DSM
6h 25m
1 stop
$341Southwest
Thu, Sep 17 - Mon, Sep 21
Southwest Logo
2:25 pm - 9:25 pm
DSM
-
SAT
7h 00m
1 stop
Southwest Logo
3:30 pm - 10:10 pm
SAT
-
DSM
6h 40m
2 stops
$346Southwest
Thu, Sep 17 - Mon, Sep 21
Southwest Logo
2:40 pm - 9:40 pm
DSM
-
SAT
7h 00m
2 stops
Southwest Logo
12:55 pm - 9:00 pm
SAT
-
DSM
8h 05m
2 stops
$351Southwest
Wed, Aug 19 - Wed, Aug 26

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Frontier flights from Des Moines to San Antonio

Our best Frontier deals on Des Moines to San Antonio flight tickets
Frontier
Sep 4
DSM2:19 pmDes Moines
5h 12m
1 stop
SAT7:31 pmSan Antonio
Sep 6
SAT8:26 pmSan Antonio
17h 08m
1 stop
DSM1:34 pmDes Moines
$315
Frontier
Aug 5
DSM2:19 pmDes Moines
28h 35m
1 stop
SAT6:54 pmSan Antonio
Aug 9
SAT7:49 pmSan Antonio
17h 45m
1 stop
DSM1:34 pmDes Moines
$375
Frontier
Aug 12
DSM2:19 pmDes Moines
28h 35m
1 stop
SAT6:54 pmSan Antonio
Aug 20
SAT10:24 pmSan Antonio
15h 10m
2 stops
DSM1:34 pmDes Moines
$403

Delta flights from Des Moines to San Antonio

Our best Delta deals on Des Moines to San Antonio flight tickets
Delta
Aug 13
DSM5:40 amDes Moines
5h 30m
1 stop
SAT11:10 amSan Antonio
Aug 19
SAT6:25 amSan Antonio
7h 40m
1 stop
DSM2:05 pmDes Moines
$317
Delta
Sep 5
DSM4:11 pmDes Moines
6h 32m
1 stop
SAT10:43 pmSan Antonio
Sep 6
SAT7:55 amSan Antonio
7h 21m
1 stop
DSM3:16 pmDes Moines
$327
Delta
Sep 1
DSM5:40 amDes Moines
7h 58m
1 stop
SAT1:38 pmSan Antonio
Sep 6
SAT5:20 amSan Antonio
6h 01m
1 stop
DSM11:21 amDes Moines
$339

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 24, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 9/4

2:19 pm-7:31 pm

1 stop5h 12m

San Antonio

Sun 9/6

8:26 pm-1:34 pm

1 stop17h 08m

$315
Quickest round-trip

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 8/13

10:59 am-5:11 pm

1 stop6h 12m

San Antonio

Tue 8/18

2:22 pm-8:59 pm

1 stop6h 37m

$317

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 8/12

2:19 pm-6:54 pm

1 stop28h 35m

San Antonio

Wed 8/19

10:24 pm-9:00 pm

1 stop22h 36m

$320

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 8/14

10:06 pm-8:37 pm

1 stop22h 31m

San Antonio

Wed 8/19

10:24 pm-9:00 pm

1 stop22h 36m

$322

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sat 9/5

5:40 am-1:38 pm

1 stop7h 58m

San Antonio

Wed 9/9

5:30 am-10:46 am

1 stop5h 16m

$327

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Tue 9/1

5:40 am-1:38 pm

1 stop7h 58m

San Antonio

Sun 9/6

5:20 am-11:21 am

1 stop6h 01m

$339

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 8/14

10:06 pm-8:37 pm

1 stop22h 31m

San Antonio

Thu 8/20

10:24 pm-6:48 pm

1 stop20h 24m

$340

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 9/17

2:25 pm-9:25 pm

1 stop7h 00m

San Antonio

Mon 9/21

5:00 am-11:25 am

1 stop6h 25m

$341

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 9/17

2:25 pm-9:25 pm

1 stop7h 00m

San Antonio

Mon 9/21

3:30 pm-10:10 pm

2 stops6h 40m

$346

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 8/19

2:40 pm-9:40 pm

2 stops7h 00m

San Antonio

Wed 8/26

12:55 pm-9:00 pm

2 stops8h 05m

$351

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Antonio?

Prices are currently typical for flights on this route.

Typical prices usually range from $313 to $493.
The lowest price recently found on this route was $315.

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of August, then book flights to San Antonio from Des Moines during October instead. Flights to San Antonio in October, while not as cheap as those in August, still average around $375.

How have Des Moines to San Antonio flight prices changed over time?

As of July 2026, prices for Des Moines to San Antonio flights are approximately 77% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Fastest flight time

5h 10m

Direct flights

None
The fastest flight from Des Moines to San Antonio takes 5h 10m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

Frequently asked questions about flying from Des Moines to San Antonio

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 5h 10m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $213Free CancellationRating
7.8
8,481 reviews
Search Delta flights
American AirlinesPriceFrom $262Free CancellationRating
7.1
11,842 reviews
Search American Airlines flights
United AirlinesPriceFrom $312Free CancellationRating
7.4
10,026 reviews
Search United Airlines flights
SouthwestPriceFrom $359Free CancellationRating
8.0
4,236 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Pleasanton
Boerne
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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