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Cheap flights from Des Moines to San Antonio from $121

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 4/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Antonio

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
2:16 pm - 6:59 pm
DSM
-
SAT
28h 43m
1 stop
Frontier Logo
7:54 pm - 1:31 pm
SAT
-
DSM
17h 37m
1 stop
$211Frontier
Fri, May 22 - Tue, May 26
Multiple Airlines Logo
2:16 pm - 6:59 pm
DSM
-
SAT
28h 43m
1 stop
Multiple Airlines Logo
7:54 pm - 12:59 pm
SAT
-
DSM
17h 05m
2 stops
$315Multiple Airlines
Fri, May 22 - Tue, May 26
Delta Logo
11:28 am - 5:32 pm
DSM
-
SAT
6h 04m
1 stop
Delta Logo
6:05 am - 2:05 pm
SAT
-
DSM
8h 00m
1 stop
$335Delta
Wed, Jun 17 - Tue, Jun 23
Southwest Logo
6:55 am - 11:55 am
DSM
-
SAT
5h 00m
1 stop
Southwest Logo
1:40 pm - 9:15 pm
SAT
-
DSM
7h 35m
2 stops
$340Southwest
Tue, May 12 - Tue, May 19
Southwest Logo
6:55 am - 2:25 pm
DSM
-
SAT
7h 30m
2 stops
Southwest Logo
1:40 pm - 9:15 pm
SAT
-
DSM
7h 35m
2 stops
$345Southwest
Tue, May 12 - Tue, May 19
Delta Logo
6:31 pm - 12:46 am
DSM
-
SAT
6h 15m
1 stop
Delta Logo
7:55 am - 3:10 pm
SAT
-
DSM
7h 15m
1 stop
$346Delta
Wed, May 6 - Sat, May 9
Southwest Logo
4:20 pm - 12:30 am
DSM
-
SAT
8h 10m
1 stop
Southwest Logo
8:55 am - 5:55 pm
SAT
-
DSM
9h 00m
1 stop
$350Southwest
Thu, May 7 - Tue, May 12
Southwest Logo
6:55 am - 5:00 pm
DSM
-
SAT
10h 05m
2 stops
Southwest Logo
6:05 am - 1:20 pm
SAT
-
DSM
7h 15m
1 stop
$351Southwest
Wed, May 6 - Sat, May 9
Multiple Airlines Logo
7:45 am - 4:16 pm
DSM
-
SAT
8h 31m
1 stop
Multiple Airlines Logo
7:54 pm - 1:31 pm
SAT
-
DSM
17h 37m
1 stop
$354Multiple Airlines
Thu, May 14 - Thu, May 21
Southwest Logo
4:20 pm - 12:30 am
DSM
-
SAT
8h 10m
1 stop
Southwest Logo
6:30 am - 2:05 pm
SAT
-
DSM
7h 35m
2 stops
$355Southwest
Thu, May 7 - Tue, May 12

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American Airlines flights from Des Moines to San Antonio

Our best American Airlines deals on Des Moines to San Antonio flight tickets
American Airlines
May 14
DSM2:02 pmDes Moines
8h 57m
1 stop
SAT10:59 pmSan Antonio
May 18
SAT7:12 pmSan Antonio
4h 47m
1 stop
DSM11:59 pmDes Moines
$365
American Airlines
Apr 30
DSM5:00 amDes Moines
4h 36m
1 stop
SAT9:36 amSan Antonio
May 5
SAT7:00 amSan Antonio
4h 26m
1 stop
DSM11:26 amDes Moines
$648
American Airlines
Apr 28
DSM12:00 pmDes Moines
5h 44m
1 stop
SAT5:44 pmSan Antonio
May 1
SAT7:12 pmSan Antonio
4h 47m
1 stop
DSM11:59 pmDes Moines
$899

Delta flights from Des Moines to San Antonio

Our best Delta deals on Des Moines to San Antonio flight tickets
Delta
Jun 17
DSM2:45 pmDes Moines
6h 47m
1 stop
SAT9:32 pmSan Antonio
Jun 23
SAT5:25 amSan Antonio
8h 36m
1 stop
DSM2:01 pmDes Moines
$335
Delta
May 22
DSM6:41 pmDes Moines
6h 03m
1 stop
SAT12:44 amSan Antonio
May 26
SAT6:08 amSan Antonio
6h 16m
1 stop
DSM12:24 pmDes Moines
$371
Delta
May 8
DSM11:57 amDes Moines
5h 19m
1 stop
SAT5:16 pmSan Antonio
May 12
SAT2:35 pmSan Antonio
6h 37m
1 stop
DSM9:12 pmDes Moines
$381

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 19, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 5/22

2:16 pm-6:59 pm

1 stop28h 43m

San Antonio

Tue 5/26

7:54 pm-1:31 pm

1 stop17h 37m

$211

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 5/22

2:16 pm-6:59 pm

1 stop28h 43m

San Antonio

Tue 5/26

7:54 pm-12:59 pm

2 stops17h 05m

$315

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 6/17

11:28 am-5:32 pm

1 stop6h 04m

San Antonio

Tue 6/23

6:05 am-2:05 pm

1 stop8h 00m

$335
Quickest round-trip

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Tue 5/12

6:55 am-11:55 am

1 stop5h 00m

San Antonio

Tue 5/19

1:40 pm-9:15 pm

2 stops7h 35m

$340

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Tue 5/12

6:55 am-2:25 pm

2 stops7h 30m

San Antonio

Tue 5/19

1:40 pm-9:15 pm

2 stops7h 35m

$345

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 5/6

6:31 pm-12:46 am

1 stop6h 15m

San Antonio

Sat 5/9

7:55 am-3:10 pm

1 stop7h 15m

$346

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 5/7

4:20 pm-12:30 am

1 stop8h 10m

San Antonio

Tue 5/12

8:55 am-5:55 pm

1 stop9h 00m

$350

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 5/6

6:55 am-5:00 pm

2 stops10h 05m

San Antonio

Sat 5/9

6:05 am-1:20 pm

1 stop7h 15m

$351

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 5/14

7:45 am-4:16 pm

1 stop8h 31m

San Antonio

Thu 5/21

7:54 pm-1:31 pm

1 stop17h 37m

$354

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 5/7

4:20 pm-12:30 am

1 stop8h 10m

San Antonio

Tue 5/12

6:30 am-2:05 pm

2 stops7h 35m

$355

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Antonio?

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of August, then book flights to San Antonio from Des Moines during July instead. Flights to San Antonio in July, while not as cheap as those in August, still average around $334.

How far in advance should I book a flight to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $404 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $290 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of April 2026, prices for Des Moines to San Antonio flights are approximately 141% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Fastest flight time

4h 45m

Direct flights

None
The fastest flight from Des Moines to San Antonio takes 4h 45m
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

Frequently asked questions about flying from Des Moines to San Antonio

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 45m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $238Free CancellationRating
7.9
8,422 reviews
Search Delta flights
American AirlinesPriceFrom $266Free CancellationRating
7.1
11,620 reviews
Search American Airlines flights
United AirlinesPriceFrom $299Free CancellationRating
7.4
9,604 reviews
Search United Airlines flights
SouthwestPriceFrom $327Free CancellationRating
8.0
4,327 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Pleasanton
Schertz

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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