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Cheap flights from Des Moines to San Antonio from $173

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 12/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:29 pm - 12:17 amDSM-SAT
27h 48m1 stop
Frontier Logo
6:45 am - 7:44 pmSAT-DSM
12h 59m1 stop
$219Frontier
Find Deal
lun., dic. 22 - lun., dic. 29
Frontier Logo
8:29 pm - 11:21 amDSM-SAT
14h 52m1 stop
Frontier Logo
6:45 am - 7:44 pmSAT-DSM
12h 59m1 stop
$244Frontier
Find Deal
sáb., dic. 20 - sáb., dic. 27
Delta Logo
6:54 am - 12:13 pmDSM-SAT
5h 19m1 stop
Delta Logo
5:30 am - 11:24 amSAT-DSM
5h 54m1 stop
$315Delta
Find Deal
mar., ene. 13 - dom., ene. 18
Delta Logo
2:16 pm - 9:03 pmDSM-SAT
6h 47m1 stop
Delta Logo
3:00 pm - 10:34 pmSAT-DSM
7h 34m1 stop
$317Delta
Find Deal
mar., dic. 2 - mar., dic. 9
United Airlines Logo
1:35 pm - 8:44 pmDSM-SAT
7h 09m1 stop
United Airlines Logo
2:15 pm - 11:44 pmSAT-DSM
9h 29m2 stops
$320United Airlines
Find Deal
mar., ene. 13 - dom., ene. 18
Southwest Logo
8:35 am - 5:40 pmDSM-SAT
9h 05m2 stops
Southwest Logo
5:45 am - 12:40 pmSAT-DSM
6h 55m1 stop
$322Southwest
Find Deal
mié., ene. 28 - sáb., ene. 31
United Airlines Logo
1:35 pm - 10:57 pmDSM-SAT
9h 22m2 stops
United Airlines Logo
4:04 pm - 11:44 pmSAT-DSM
7h 40m2 stops
$325United Airlines
Find Deal
mar., ene. 13 - dom., ene. 18
Southwest Logo
3:20 pm - 11:05 pmDSM-SAT
7h 45m2 stops
Southwest Logo
6:15 am - 8:20 pmSAT-DSM
14h 05m2 stops
$327Southwest
Find Deal
mié., ene. 28 - sáb., ene. 31
American Airlines Logo
5:39 pm - 10:59 pmDSM-SAT
5h 20m1 stop
American Airlines Logo
6:00 pm - 11:35 pmSAT-DSM
5h 35m1 stop
$384American Airlines
Find Deal
dom., dic. 21 - dom., dic. 28
American Airlines Logo
5:39 pm - 11:51 pmDSM-SAT
6h 12m1 stop
American Airlines Logo
6:00 am - 10:47 amSAT-DSM
4h 47m1 stop
$387American Airlines
Find Deal
sáb., dic. 20 - sáb., dic. 27

Delta flights from Des Moines to San Antonio

Our best Delta deals on Des Moines to San Antonio flight tickets
Delta
Jan 13
DSM6:54 amDes Moines
5h 19m
1 stop
SAT12:13 pmSan Antonio
Jan 18
SAT5:30 amSan Antonio
5h 54m
1 stop
DSM11:24 amDes Moines
$315
Find similar
Delta
Dec 2
DSM2:16 pmDes Moines
6h 47m
1 stop
SAT9:03 pmSan Antonio
Dec 9
SAT3:00 pmSan Antonio
7h 34m
1 stop
DSM10:34 pmDes Moines
$317
Find similar
Delta
Feb 19
DSM5:15 pmDes Moines
7h 21m
1 stop
SAT12:36 amSan Antonio
Feb 23
SAT4:29 pmSan Antonio
6h 02m
1 stop
DSM10:31 pmDes Moines
$329
Find similar

Southwest flights from Des Moines to San Antonio

Our best Southwest deals on Des Moines to San Antonio flight tickets
Southwest
Jan 28
DSM8:35 amDes Moines
9h 05m
2 stops
SAT5:40 pmSan Antonio
Jan 31
SAT5:45 amSan Antonio
6h 55m
1 stop
DSM12:40 pmDes Moines
$322
Find similar
Southwest
Jan 28
DSM3:20 pmDes Moines
7h 45m
2 stops
SAT11:05 pmSan Antonio
Jan 31
SAT6:15 amSan Antonio
14h 05m
2 stops
DSM8:20 pmDes Moines
$327
Find similar
Southwest
Jan 6
DSM8:35 amDes Moines
5h 25m
1 stop
SAT2:00 pmSan Antonio
Jan 8
SAT2:45 pmSan Antonio
6h 25m
2 stops
DSM9:10 pmDes Moines
$336
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated noviembre 6, 2025.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

lun. 12/22

8:29 pm-12:17 am

1 stop27h 48m

San Antonio

lun. 12/29

6:45 am-7:44 pm

1 stop12h 59m

$219

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

sáb. 12/20

8:29 pm-11:21 am

1 stop14h 52m

San Antonio

sáb. 12/27

6:45 am-7:44 pm

1 stop12h 59m

$244

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mar. 1/13

6:54 am-12:13 pm

1 stop5h 19m

San Antonio

dom. 1/18

5:30 am-11:24 am

1 stop5h 54m

$315

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mar. 12/2

2:16 pm-9:03 pm

1 stop6h 47m

San Antonio

mar. 12/9

3:00 pm-10:34 pm

1 stop7h 34m

$317

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mar. 1/13

1:35 pm-8:44 pm

1 stop7h 09m

San Antonio

dom. 1/18

2:15 pm-11:44 pm

2 stops9h 29m

$320

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mié. 1/28

8:35 am-5:40 pm

2 stops9h 05m

San Antonio

sáb. 1/31

5:45 am-12:40 pm

1 stop6h 55m

$322

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mar. 1/13

1:35 pm-10:57 pm

2 stops9h 22m

San Antonio

dom. 1/18

4:04 pm-11:44 pm

2 stops7h 40m

$325

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mié. 1/28

3:20 pm-11:05 pm

2 stops7h 45m

San Antonio

sáb. 1/31

6:15 am-8:20 pm

2 stops14h 05m

$327

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

dom. 12/21

5:39 pm-10:59 pm

1 stop5h 20m

San Antonio

dom. 12/28

6:00 pm-11:35 pm

1 stop5h 35m

$384

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

sáb. 12/20

5:39 pm-11:51 pm

1 stop6h 12m

San Antonio

sáb. 12/27

6:00 am-10:47 am

1 stop4h 47m

$387

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of August, then book flights to San Antonio from Des Moines during July instead. Flights to San Antonio in July, while not as cheap as those in August, still average around $334.

What is the cheapest day to depart on your flight to San Antonio?

The cheapest day to depart on your flight to San Antonio is on a Wednesday when prices can be found for as low as $366. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to San Antonio on Monday is $411.

What is the cheapest time of day to depart on your flight to San Antonio?

According to our data, the cheapest time of day to fly to San Antonio is in the evening. momondo users have found flights departing from Des Moines to San Antonio in the evening for as low as $301. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to San Antonio are more costly in the morning, with an average ticket price of $402. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $402 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $334 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of November 2025, prices for Des Moines to San Antonio flights are approximately 46% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Direct flights

None
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 46m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $280Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
DeltaPriceFrom $283Free CancellationRating
7.9
8,001 reviews
Search Delta flights
United AirlinesPriceFrom $299Free CancellationRating
7.4
9,007 reviews
Search United Airlines flights
SouthwestPriceFrom $327Free CancellationRating
8.0
4,241 reviews
Search Southwest flights

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Boerne
Kerrville
Schertz
Pleasanton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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sáb. 12/6
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