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Cheap flights from Des Moines to San Antonio from $72

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Antonio departing on 10/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Frontier Logo
7:36 pm - 9:18 amDSM-SAT
13h 42m1 stop
Frontier Logo
10:13 am - 6:41 pmSAT-DSM
8h 28m1 stop
$177Frontier
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Thu, Feb 19 - Sun, Feb 22
Frontier Logo
7:36 pm - 9:18 amDSM-SAT
13h 42m1 stop
Frontier Logo
10:13 am - 6:41 pmSAT-DSM
8h 28m1 stop
$180Frontier
Find Deal
Thu, Feb 19 - Sun, Feb 22
Southwest Logo
5:25 am - 11:05 amDSM-SAT
5h 40m1 stop
Southwest Logo
12:45 pm - 9:35 pmSAT-DSM
8h 50m2 stops
$234Southwest
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Sat, Dec 13 - Wed, Dec 17
Delta Logo
10:20 am - 4:04 pmDSM-SAT
5h 44m1 stop
Delta Logo
2:51 pm - 8:02 pmSAT-DSM
5h 11m1 stop
$251Delta
Find Deal
Tue, Dec 16 - Thu, Dec 25
Southwest Logo
6:50 pm - 12:15 amDSM-SAT
5h 25m1 stop
Southwest Logo
5:00 am - 11:00 amSAT-DSM
6h 00m1 stop
$252Southwest
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Tue, Dec 23 - Tue, Dec 30
American Airlines Logo
1:17 pm - 10:00 pmDSM-SAT
8h 43m1 stop
American Airlines Logo
2:31 pm - 11:59 pmSAT-DSM
9h 28m1 stop
$264American Airlines
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Wed, Dec 3 - Fri, Dec 5
Delta Logo
10:20 am - 4:04 pmDSM-SAT
5h 44m1 stop
Delta Logo
2:51 pm - 8:02 pmSAT-DSM
5h 11m1 stop
$268Delta
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Mon, Dec 15 - Wed, Dec 24
American Airlines Logo
5:00 am - 11:58 amDSM-SAT
6h 58m1 stop
American Airlines Logo
2:31 pm - 11:59 pmSAT-DSM
9h 28m1 stop
$316American Airlines
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Fri, Dec 5 - Fri, Dec 12
United Airlines Logo
3:17 pm - 10:59 pmDSM-SAT
7h 42m2 stops
United Airlines Logo
2:08 pm - 9:40 pmSAT-DSM
7h 32m1 stop
$326United Airlines
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Tue, Dec 16 - Thu, Dec 25
United Airlines Logo
1:31 pm - 10:59 pmDSM-SAT
9h 28m2 stops
United Airlines Logo
4:34 pm - 11:44 pmSAT-DSM
7h 10m1 stop
$340United Airlines
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Wed, Dec 3 - Fri, Dec 5

Delta flights from Des Moines to San Antonio

Our best Delta deals on Des Moines to San Antonio flight tickets
Delta
Dec 16
DSM5:34 amDes Moines
8h 09m
1 stop
SAT1:43 pmSan Antonio
Dec 24
SAT6:00 amSan Antonio
5h 28m
1 stop
DSM11:28 amDes Moines
$251
Find similar
Delta
Dec 15
DSM10:20 amDes Moines
5h 44m
1 stop
SAT4:04 pmSan Antonio
Dec 24
SAT2:51 pmSan Antonio
5h 11m
1 stop
DSM8:02 pmDes Moines
$268
Find similar
Delta
Dec 14
DSM2:59 pmDes Moines
6h 20m
1 stop
SAT9:19 pmSan Antonio
Dec 25
SAT7:05 amSan Antonio
5h 23m
1 stop
DSM12:28 pmDes Moines
$302
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United Airlines flights from Des Moines to San Antonio

Our best United Airlines deals on Des Moines to San Antonio flight tickets
United Airlines
Dec 16
DSM1:31 pmDes Moines
9h 28m
2 stops
SAT10:59 pmSan Antonio
Dec 24
SAT2:13 pmSan Antonio
5h 08m
1 stop
DSM7:21 pmDes Moines
$326
Find similar
United Airlines
Dec 3
DSM1:31 pmDes Moines
9h 28m
2 stops
SAT10:59 pmSan Antonio
Dec 5
SAT4:34 pmSan Antonio
7h 10m
1 stop
DSM11:44 pmDes Moines
$340
Find similar
United Airlines
Dec 15
DSM3:17 pmDes Moines
7h 42m
2 stops
SAT10:59 pmSan Antonio
Dec 24
SAT4:55 pmSan Antonio
7h 03m
1 stop
DSM11:58 pmDes Moines
$343
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momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 21, 2025.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 2/19

7:36 pm-9:18 am

1 stop13h 42m

San Antonio

Sun 2/22

10:13 am-6:41 pm

1 stop8h 28m

$177

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 2/19

7:36 pm-9:18 am

1 stop13h 42m

San Antonio

Sun 2/22

10:13 am-6:41 pm

1 stop8h 28m

$180

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sat 12/13

5:25 am-11:05 am

1 stop5h 40m

San Antonio

Wed 12/17

12:45 pm-9:35 pm

2 stops8h 50m

$234

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Tue 12/16

10:20 am-4:04 pm

1 stop5h 44m

San Antonio

Thu 12/25

2:51 pm-8:02 pm

1 stop5h 11m

$251

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Tue 12/23

6:50 pm-12:15 am

1 stop5h 25m

San Antonio

Tue 12/30

5:00 am-11:00 am

1 stop6h 00m

$252

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 12/3

1:17 pm-10:00 pm

1 stop8h 43m

San Antonio

Fri 12/5

2:31 pm-11:59 pm

1 stop9h 28m

$264

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Mon 12/15

10:20 am-4:04 pm

1 stop5h 44m

San Antonio

Wed 12/24

2:51 pm-8:02 pm

1 stop5h 11m

$268

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Fri 12/5

5:00 am-11:58 am

1 stop6h 58m

San Antonio

Fri 12/12

2:31 pm-11:59 pm

1 stop9h 28m

$316

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Tue 12/16

3:17 pm-10:59 pm

2 stops7h 42m

San Antonio

Thu 12/25

2:08 pm-9:40 pm

1 stop7h 32m

$326

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Wed 12/3

1:31 pm-10:59 pm

2 stops9h 28m

San Antonio

Fri 12/5

4:34 pm-11:44 pm

1 stop7h 10m

$340

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Antonio from

How to get the cheapest flight ticket from Des Moines to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Antonio?

If you aren’t able to travel during the month of August, then book flights to San Antonio from Des Moines during July instead. Flights to San Antonio in July, while not as cheap as those in August, still average around $334.

What is the cheapest day to depart on your flight to San Antonio?

The cheapest day to depart on your flight to San Antonio is on a Wednesday when prices can be found for as low as $366. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to San Antonio on Monday is $411.

What is the cheapest time of day to depart on your flight to San Antonio?

According to our data, the cheapest time of day to fly to San Antonio is in the evening. momondo users have found flights departing from Des Moines to San Antonio in the evening for as low as $301. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to San Antonio are more costly in the morning, with an average ticket price of $402. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to San Antonio?

You are more likely to see cheaper flights to San Antonio from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Antonio for around $402 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Antonio from Des Moines for as low as $334 on momondo.

How have Des Moines to San Antonio flight prices changed over time?

As of October 2025, prices for Des Moines to San Antonio flights are approximately 14% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Antonio (DSM to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Antonio

Direct flights

None
There are no direct flights from Des Moines to San Antonio. There are no popular flight routes from Des Moines to San Antonio.
Search flight deals

  • How far is Des Moines to San Antonio by plane?

    Des Moines and San Antonio are 882.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 38m.

  • When did momondo last update prices for flights from Des Moines Airport to San Antonio Airport?

    Prices for flights from Des Moines Airport to San Antonio Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Antonio Airport?

  • How old do you have to be to fly from Des Moines Airport to San Antonio Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The necessary travel and health documents for your San Antonio Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Antonio?

Best airlines flying from Des Moines to San Antonio

Compare and see reviews for airlines that fly from Des Moines to San Antonio with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $277Free CancellationRating
7.2
11,026 reviews
Search American Airlines flights
DeltaPriceFrom $283Free CancellationRating
7.9
7,981 reviews
Search Delta flights
United AirlinesPriceFrom $299Free CancellationRating
7.4
8,988 reviews
Search United Airlines flights
SouthwestPriceFrom $327Free CancellationRating
8.0
4,237 reviews
Search Southwest flights

  • Southwest Flights From Des Moines to San Antonio

    Southwest operates around 3 flights from Des Moines to San Antonio every week. The average price of these flights found in the last 72 hours has been $382, but momondo users have found Southwest deals from Des Moines to San Antonio from as low as $327 round-trip. Southwest has been scored 8.0/10 in 4,238 reviews.

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Schertz
Pleasanton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Antonio?

Finding the right flight to San Antonio from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Antonio quick and easy, saving you time and money.

Can I find flights from Des Moines to San Antonio with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to San Antonio flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to San Antonio?

momondo provides multiple filters to help you find the best flight to San Antonio from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Antonio right now. Can momondo alert me if prices change?

Price alerts on flights to San Antonio from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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