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Cheap flights from Knoxville to San Francisco from $415

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Francisco departing on 8/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Knoxville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
1:55 pm - 9:25 pm
TYS
-
STS
10h 30m
2 stops
Southwest Logo
2:55 pm - 12:05 pm
STS
-
TYS
18h 10m
2 stops
$423Southwest
Tue, Aug 18 - Mon, Aug 24
American Airlines Logo
6:20 am - 3:41 pm
TYS
-
STS
12h 21m
2 stops
American Airlines Logo
4:11 pm - 8:32 am
STS
-
TYS
13h 21m
2 stops
$475American Airlines
Tue, Oct 6 - Tue, Oct 13
Southwest Logo
2:05 pm - 10:40 pm
TYS
-
STS
11h 35m
2 stops
Southwest Logo
4:40 pm - 12:05 pm
STS
-
TYS
16h 25m
2 stops
$491Southwest
Mon, Sep 14 - Mon, Sep 21
American Airlines Logo
6:00 am - 12:13 pm
TYS
-
STS
9h 13m
1 stop
American Airlines Logo
4:11 pm - 8:32 am
STS
-
TYS
13h 21m
2 stops
$496American Airlines
Tue, Oct 6 - Tue, Oct 13
American Airlines Logo
6:00 am - 3:53 pm
TYS
-
STS
12h 53m
2 stops
American Airlines Logo
4:11 pm - 8:32 am
STS
-
TYS
13h 21m
2 stops
$526American Airlines
Thu, Oct 8 - Tue, Oct 13
Southwest Logo
1:50 pm - 11:15 pm
TYS
-
STS
12h 25m
2 stops
Southwest Logo
6:35 am - 9:00 pm
STS
-
TYS
11h 25m
2 stops
$535Southwest
Thu, Oct 8 - Tue, Oct 13
American Airlines Logo
6:00 am - 12:13 pm
TYS
-
STS
9h 13m
1 stop
American Airlines Logo
12:43 pm - 11:22 pm
STS
-
TYS
7h 39m
1 stop
$628American Airlines
Tue, Oct 6 - Tue, Oct 13
American Airlines Logo
6:00 am - 3:53 pm
TYS
-
STS
12h 53m
2 stops
American Airlines Logo
12:43 pm - 11:22 pm
STS
-
TYS
7h 39m
1 stop
$641American Airlines
Thu, Oct 8 - Tue, Oct 13
American Airlines Logo
6:00 am - 3:53 pm
TYS
-
STS
12h 53m
2 stops
American Airlines Logo
12:43 pm - 11:22 pm
STS
-
TYS
7h 39m
1 stop
$644American Airlines
Thu, Oct 8 - Tue, Oct 13
American Airlines Logo
6:00 am - 3:53 pm
TYS
-
STS
12h 53m
2 stops
American Airlines Logo
12:43 pm - 11:22 pm
STS
-
TYS
7h 39m
1 stop
$646American Airlines
Thu, Oct 8 - Tue, Oct 13

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Southwest flights from Knoxville to Santa Rosa

Our best Southwest deals on Knoxville to Santa Rosa flight tickets
Southwest
Aug 18
TYS1:55 pmKnoxville McGhee Tyson
10h 30m
2 stops
STS9:25 pmSanta Rosa Sonoma County
Aug 24
STS2:55 pmSanta Rosa Sonoma County
18h 10m
2 stops
TYS12:05 pmKnoxville McGhee Tyson
$423
Southwest
Sep 14
TYS2:05 pmKnoxville McGhee Tyson
11h 35m
2 stops
STS10:40 pmSanta Rosa Sonoma County
Sep 21
STS4:40 pmSanta Rosa Sonoma County
16h 25m
2 stops
TYS12:05 pmKnoxville McGhee Tyson
$491
Southwest
Oct 8
TYS1:50 pmKnoxville McGhee Tyson
12h 25m
2 stops
STS11:15 pmSanta Rosa Sonoma County
Oct 13
STS6:35 amSanta Rosa Sonoma County
11h 25m
2 stops
TYS9:00 pmKnoxville McGhee Tyson
$535

Alaska Airlines flights from Knoxville to Santa Rosa

Our best Alaska Airlines deals on Knoxville to Santa Rosa flight tickets
Alaska Airlines
Oct 31
TYS11:40 amKnoxville McGhee Tyson
13h 16m
2 stops
STS9:56 pmSanta Rosa Sonoma County
Nov 4
STS7:00 amSanta Rosa Sonoma County
13h 31m
2 stops
TYS11:31 pmKnoxville McGhee Tyson
$873
Alaska Airlines
Nov 5
TYS11:44 amKnoxville McGhee Tyson
13h 13m
2 stops
STS9:57 pmSanta Rosa Sonoma County
Nov 10
STS7:00 amSanta Rosa Sonoma County
12h 51m
2 stops
TYS10:51 pmKnoxville McGhee Tyson
$878
Alaska Airlines
Oct 31
TYS11:40 amKnoxville McGhee Tyson
13h 16m
2 stops
STS9:56 pmSanta Rosa Sonoma County
Nov 4
STS7:00 amSanta Rosa Sonoma County
13h 31m
2 stops
TYS11:31 pmKnoxville McGhee Tyson
$884

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Rosa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 25, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Rosa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Tue 8/18

1:55 pm-9:25 pm

2 stops10h 30m

Santa Rosa Sonoma County

Mon 8/24

2:55 pm-12:05 pm

2 stops18h 10m

$423

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Tue 10/6

6:20 am-3:41 pm

2 stops12h 21m

Santa Rosa Sonoma County

Tue 10/13

4:11 pm-8:32 am

2 stops13h 21m

$475

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Mon 9/14

2:05 pm-10:40 pm

2 stops11h 35m

Santa Rosa Sonoma County

Mon 9/21

4:40 pm-12:05 pm

2 stops16h 25m

$491

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Tue 10/6

6:00 am-12:13 pm

1 stop9h 13m

Santa Rosa Sonoma County

Tue 10/13

4:11 pm-8:32 am

2 stops13h 21m

$496

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Thu 10/8

6:00 am-3:53 pm

2 stops12h 53m

Santa Rosa Sonoma County

Tue 10/13

4:11 pm-8:32 am

2 stops13h 21m

$526

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Thu 10/8

1:50 pm-11:15 pm

2 stops12h 25m

Santa Rosa Sonoma County

Tue 10/13

6:35 am-9:00 pm

2 stops11h 25m

$535
Quickest round-trip

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Tue 10/6

6:00 am-12:13 pm

1 stop9h 13m

Santa Rosa Sonoma County

Tue 10/13

12:43 pm-11:22 pm

1 stop7h 39m

$628

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Thu 10/8

6:00 am-3:53 pm

2 stops12h 53m

Santa Rosa Sonoma County

Tue 10/13

12:43 pm-11:22 pm

1 stop7h 39m

$641

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Thu 10/8

6:00 am-3:53 pm

2 stops12h 53m

Santa Rosa Sonoma County

Tue 10/13

12:43 pm-11:22 pm

1 stop7h 39m

$644

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Thu 10/8

6:00 am-3:53 pm

2 stops12h 53m

Santa Rosa Sonoma County

Tue 10/13

12:43 pm-11:22 pm

1 stop7h 39m

$646

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Knoxville to Santa Rosa

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Knoxville to Santa Rosa flights?

You could potentially save up to 51% on your flight if you consider stops on a Knoxville to Santa Rosa flight.

When to book flights from Knoxville to Santa Rosa

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santa Rosa according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santa Rosa (TYS to STS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santa Rosa

Fastest flight time

10h 58m

Direct flights

None
The fastest flight from Knoxville to Santa Rosa takes 10h 58m
There are no direct flights from Knoxville to Santa Rosa. There are no popular flight routes from Knoxville to Santa Rosa.
Search flight deals

Frequently asked questions about flying from Knoxville to Santa Rosa

  • How far is Knoxville McGhee Tyson to Santa Rosa Sonoma County by plane?

    A flight from Knoxville McGhee Tyson to Santa Rosa Sonoma County will travel around 2124.6 mi. 10h 58m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santa Rosa Sonoma County Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santa Rosa Sonoma County Airport are updated daily.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santa Rosa Sonoma County Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santa Rosa Sonoma County Airport.

  • What documentation or ID do you need to fly to Santa Rosa Sonoma County Airport?

    The required travel and health documents for your Santa Rosa Sonoma County Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Rosa Sonoma County Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Fort Bragg
Ukiah
Mendocino
Little River
Point Arena

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santa Rosa?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Santa Rosa. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Santa Rosa with flexible booking policies on momondo?

Flights from Knoxville to Santa Rosa with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Santa Rosa?

Once you have performed a search for Knoxville to Santa Rosa flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to Santa Rosa right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Santa Rosa now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santa Rosa and let you know when they change.

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