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Cheap flights from Knoxville to San Francisco from $228

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Francisco departing on 7/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Knoxville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 3:50 pm
TYS
-
STS
12h 50m
2 stops
American Airlines Logo
12:39 pm - 11:22 pm
STS
-
TYS
7h 43m
1 stop
$443American Airlines
Sat, Sep 12 - Sat, Sep 26
American Airlines Logo
6:00 am - 12:09 pm
TYS
-
STS
9h 09m
1 stop
American Airlines Logo
12:39 pm - 11:22 pm
STS
-
TYS
7h 43m
1 stop
$453American Airlines
Sat, Sep 12 - Sat, Sep 26
American Airlines Logo
5:37 am - 12:03 pm
TYS
-
STS
9h 26m
1 stop
American Airlines Logo
12:43 pm - 11:51 pm
STS
-
TYS
8h 08m
1 stop
$464American Airlines
Tue, Jul 7 - Tue, Jul 14
American Airlines Logo
6:00 am - 12:09 pm
TYS
-
STS
9h 09m
1 stop
American Airlines Logo
12:39 pm - 11:22 pm
STS
-
TYS
7h 43m
1 stop
$529American Airlines
Sat, Sep 12 - Sat, Sep 26
American Airlines Logo
7:30 am - 3:50 pm
TYS
-
STS
11h 20m
2 stops
American Airlines Logo
12:39 pm - 11:22 pm
STS
-
TYS
7h 43m
1 stop
$534American Airlines
Sat, Sep 12 - Sat, Sep 26
Southwest Logo
12:45 pm - 10:50 pm
TYS
-
STS
13h 05m
2 stops
Southwest Logo
6:00 am - 8:25 pm
STS
-
TYS
11h 25m
2 stops
$649Southwest
Tue, Jul 7 - Tue, Jul 14
Delta Logo
5:30 am - 4:08 pm
TYS
-
STS
13h 38m
2 stops
Delta Logo
4:55 pm - 9:12 am
STS
-
TYS
13h 17m
2 stops
$679Delta
Thu, Oct 8 - Sat, Oct 17
American Airlines Logo
5:37 am - 12:05 pm
TYS
-
STS
9h 28m
1 stop
American Airlines Logo
12:43 pm - 11:51 pm
STS
-
TYS
8h 08m
1 stop
$689American Airlines
Tue, Jun 23 - Thu, Jul 9
American Airlines Logo
5:37 am - 12:30 pm
TYS
-
STS
9h 53m
2 stops
American Airlines Logo
12:43 pm - 11:51 pm
STS
-
TYS
8h 08m
1 stop
$762American Airlines
Tue, Jul 7 - Tue, Jul 14
American Airlines Logo
5:00 am - 12:39 pm
TYS
-
STS
10h 39m
2 stops
American Airlines Logo
12:43 pm - 11:51 pm
STS
-
TYS
8h 08m
1 stop
$812American Airlines
Tue, Jun 23 - Thu, Jul 9

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Alaska Airlines flights from Knoxville to Santa Rosa

Our best Alaska Airlines deals on Knoxville to Santa Rosa flight tickets
Alaska Airlines
Oct 31
TYS11:42 amKnoxville McGhee Tyson
13h 14m
2 stops
STS9:56 pmSanta Rosa Sonoma County
Nov 3
STS7:00 amSanta Rosa Sonoma County
13h 52m
2 stops
TYS11:52 pmKnoxville McGhee Tyson
$873
Alaska Airlines
Aug 14
TYS1:46 pmKnoxville McGhee Tyson
12h 05m
2 stops
STS10:51 pmSanta Rosa Sonoma County
Aug 18
STS7:00 amSanta Rosa Sonoma County
11h 53m
2 stops
TYS9:53 pmKnoxville McGhee Tyson
$4,359

American Airlines flights from Knoxville to Santa Rosa

Our best American Airlines deals on Knoxville to Santa Rosa flight tickets
American Airlines
Sep 12
TYS6:00 amKnoxville McGhee Tyson
12h 50m
2 stops
STS3:50 pmSanta Rosa Sonoma County
Sep 26
STS12:39 pmSanta Rosa Sonoma County
7h 43m
1 stop
TYS11:22 pmKnoxville McGhee Tyson
$443
American Airlines
Sep 12
TYS6:00 amKnoxville McGhee Tyson
9h 09m
1 stop
STS12:09 pmSanta Rosa Sonoma County
Sep 26
STS12:39 pmSanta Rosa Sonoma County
7h 43m
1 stop
TYS11:22 pmKnoxville McGhee Tyson
$453
American Airlines
Jul 7
TYS5:37 amKnoxville McGhee Tyson
9h 26m
1 stop
STS12:03 pmSanta Rosa Sonoma County
Jul 14
STS12:43 pmSanta Rosa Sonoma County
8h 08m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
$464

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Rosa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Rosa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Sat 9/12

6:00 am-3:50 pm

2 stops12h 50m

Santa Rosa Sonoma County

Sat 9/26

12:39 pm-11:22 pm

1 stop7h 43m

$443
Quickest round-trip

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Sat 9/12

6:00 am-12:09 pm

1 stop9h 09m

Santa Rosa Sonoma County

Sat 9/26

12:39 pm-11:22 pm

1 stop7h 43m

$453

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Tue 7/7

5:37 am-12:03 pm

1 stop9h 26m

Santa Rosa Sonoma County

Tue 7/14

12:43 pm-11:51 pm

1 stop8h 08m

$464

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Sat 9/12

6:00 am-12:09 pm

1 stop9h 09m

Santa Rosa Sonoma County

Sat 9/26

12:39 pm-11:22 pm

1 stop7h 43m

$529

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Sat 9/12

7:30 am-3:50 pm

2 stops11h 20m

Santa Rosa Sonoma County

Sat 9/26

12:39 pm-11:22 pm

1 stop7h 43m

$534

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Tue 7/7

12:45 pm-10:50 pm

2 stops13h 05m

Santa Rosa Sonoma County

Tue 7/14

6:00 am-8:25 pm

2 stops11h 25m

$649

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Thu 10/8

5:30 am-4:08 pm

2 stops13h 38m

Santa Rosa Sonoma County

Sat 10/17

4:55 pm-9:12 am

2 stops13h 17m

$679

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Tue 6/23

5:37 am-12:05 pm

1 stop9h 28m

Santa Rosa Sonoma County

Thu 7/9

12:43 pm-11:51 pm

1 stop8h 08m

$689

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Tue 7/7

5:37 am-12:30 pm

2 stops9h 53m

Santa Rosa Sonoma County

Tue 7/14

12:43 pm-11:51 pm

1 stop8h 08m

$762

KnoxvilleSanta Rosa

TYS - STS

TYSSTS

Knoxville McGhee Tyson

Tue 6/23

5:00 am-12:39 pm

2 stops10h 39m

Santa Rosa Sonoma County

Thu 7/9

12:43 pm-11:51 pm

1 stop8h 08m

$812

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Knoxville to Santa Rosa

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Knoxville to Santa Rosa flights?

You could potentially save up to 51% on your flight if you consider stops on a Knoxville to Santa Rosa flight.

When to book flights from Knoxville to Santa Rosa

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santa Rosa according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santa Rosa (TYS to STS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santa Rosa

Fastest flight time

9h 09m

Direct flights

None
The fastest flight from Knoxville to Santa Rosa takes 9h 09m
There are no direct flights from Knoxville to Santa Rosa. There are no popular flight routes from Knoxville to Santa Rosa.
Search flight deals

Frequently asked questions about flying from Knoxville to Santa Rosa

  • How far is Knoxville McGhee Tyson to Santa Rosa Sonoma County by plane?

    A flight from Knoxville McGhee Tyson to Santa Rosa Sonoma County will travel around 2124.6 mi. 9h 09m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santa Rosa Sonoma County Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santa Rosa Sonoma County Airport are updated daily.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santa Rosa Sonoma County Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santa Rosa Sonoma County Airport.

  • What documentation or ID do you need to fly to Santa Rosa Sonoma County Airport?

    The required travel and health documents for your Santa Rosa Sonoma County Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Rosa Sonoma County Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Fort Bragg
Mendocino
Ukiah
Little River
Point Arena

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santa Rosa?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Santa Rosa. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Santa Rosa with flexible booking policies on momondo?

Flights from Knoxville to Santa Rosa with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Santa Rosa?

Once you have performed a search for Knoxville to Santa Rosa flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to Santa Rosa right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Santa Rosa now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santa Rosa and let you know when they change.

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