Cheap flights from Indianapolis to San Diego from $104

If you are unable to visit San Diego during the month of May, then departing from Indianapolis during the month September is also very affordable. Most momondo users find prices during this month for around $315.

The cheapest day to depart from Indianapolis to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $418. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $589. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $484. Flights in the evening are often more expensive with an average ticket price of $573.

Fly from Indianapolis to San Diego for the best Indianapolis - San Diego flight prices

You are more likely to see cheaper flights to San Diego from Indianapolis when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $366 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Indianapolis for as low as $302 on momondo.

Delta and United Airlines are the most popular carriers operating from Indianapolis to San Diego

American Airlines, Southwest and Delta are the top three most popular airlines that fly to San Diego from Indianapolis according to our data. American Airlines is the first choice among our users, with 39% of people opting to fly with this airline when traveling to San Diego. Keep in mind that there are 8 different airlines that fly to San Diego on a routine basis, so you have a few additional options to choose from.

Denver (DEN) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Denver (DEN) offer the lowest average round-trip price of $221.

Flights connecting via Phoenix (PHX) have the shortest average one-way travel time: 6h 02m.

Phoenix (PHX) has the shortest average layover time for this route: 0h 54m.

The number of flights available between Indianapolis and San Diego is 1 per day as of May 2026. The most frequent departure time is 1:00PM, with 100% of daily flights leaving in the afternoon.

9 flights are operational weekly from Indianapolis to San Diego as of May 2026. The most popular departure day for this route is Mon, with 33% of flights per week taking off on this day.