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Cheap flights from St. Louis to San Diego from $71

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to San Diego departing on 10/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from St. Louis to San Diego

Cheap round-trip flights

Frontier Logo
7:52 pm - 11:50 pmSTL-SAN
5h 58m1 stop
Frontier Logo
8:00 am - 3:56 pmSAN-STL
5h 56m1 stop
$142Frontier
Find Deal
Wed, Oct 22 - Sat, Oct 25
Frontier Logo
7:52 pm - 11:50 pmSTL-SAN
5h 58m1 stop
Frontier Logo
7:23 pm - 9:32 amSAN-STL
12h 09m1 stop
$144Frontier
Find Deal
Fri, Oct 24 - Sun, Oct 26
Frontier Logo
7:52 pm - 8:08 pmSTL-SAN
26h 16m1 stop
Frontier Logo
2:24 pm - 9:07 amSAN-STL
16h 43m1 stop
$145Frontier
Find Deal
Thu, Oct 23 - Wed, Oct 29
Frontier Logo
7:52 pm - 11:50 pmSTL-SAN
5h 58m1 stop
Frontier Logo
2:24 pm - 9:07 amSAN-STL
16h 43m1 stop
$149Frontier
Find Deal
Wed, Oct 22 - Wed, Oct 29
Logo
9:35 pm - 6:30 pmSTL-SAN
22h 55m1 stop
Logo
1:35 pm - 9:06 amSAN-STL
17h 31m2 stops
$194
Find Deal
Fri, Sep 19 - Mon, Sep 22
Logo
7:55 pm - 11:34 pmSTL-SAN
29h 39m2 stops
Logo
8:00 am - 4:03 pmSAN-STL
6h 03m1 stop
$198
Find Deal
Tue, Sep 16 - Sat, Sep 20
American Airlines Logo
6:10 am - 2:03 pmSTL-SAN
9h 53m1 stop
American Airlines Logo
8:18 am - 6:36 pmSAN-STL
8h 18m1 stop
$268American Airlines
Find Deal
Wed, Oct 1 - Wed, Oct 8
Southwest Logo
4:25 pm - 6:20 pmSTL-SAN
3h 55mnonstop
Southwest Logo
8:40 am - 2:20 pmSAN-STL
3h 40mnonstop
$272Southwest
Find Deal
Thu, Oct 23 - Wed, Oct 29
American Airlines Logo
2:04 pm - 9:02 pmSTL-SAN
8h 58m1 stop
American Airlines Logo
1:36 pm - 11:55 pmSAN-STL
8h 19m1 stop
$273American Airlines
Find Deal
Wed, Dec 24 - Wed, Dec 31
Southwest Logo
5:40 am - 10:25 amSTL-SAN
6h 45m1 stop
Southwest Logo
8:40 am - 2:20 pmSAN-STL
3h 40mnonstop
$277Southwest
Find Deal
Thu, Oct 23 - Wed, Oct 29

American Airlines flights from St. Louis to San Diego

Our best American Airlines deals on St. Louis to San Diego flight tickets
American Airlines
Oct 1
STL6:10 amLambert-St Louis
9h 53m
1 stop
SAN2:03 pmSan Diego
Oct 8
SAN8:18 amSan Diego
8h 18m
1 stop
STL6:36 pmLambert-St Louis
$268
Find similar
American Airlines
Dec 24
STL2:04 pmLambert-St Louis
8h 58m
1 stop
SAN9:02 pmSan Diego
Dec 31
SAN1:36 pmSan Diego
8h 19m
1 stop
STL11:55 pmLambert-St Louis
$273
Find similar
American Airlines
Sep 29
STL6:05 amLambert-St Louis
9h 58m
1 stop
SAN2:03 pmSan Diego
Oct 6
SAN3:06 pmSan Diego
6h 48m
1 stop
STL11:54 pmLambert-St Louis
$287
Find similar

Frontier flights from St. Louis to San Diego

Our best Frontier deals on St. Louis to San Diego flight tickets
Frontier
Oct 22
STL7:52 pmLambert-St Louis
5h 58m
1 stop
SAN11:50 pmSan Diego
Oct 25
SAN8:00 amSan Diego
5h 56m
1 stop
STL3:56 pmLambert-St Louis
$142
Find similar
Frontier
Oct 24
STL7:52 pmLambert-St Louis
5h 58m
1 stop
SAN11:50 pmSan Diego
Oct 26
SAN7:23 pmSan Diego
12h 09m
1 stop
STL9:32 amLambert-St Louis
$144
Find similar
Frontier
Oct 23
STL7:52 pmLambert-St Louis
26h 16m
1 stop
SAN8:08 pmSan Diego
Oct 29
SAN2:24 pmSan Diego
16h 43m
1 stop
STL9:07 amLambert-St Louis
$145
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 2, 2025.
Use the filters below to find and compare flights from St. Louis to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 10/22

7:52 pm-11:50 pm

1 stop5h 58m

San Diego

Sat 10/25

8:00 am-3:56 pm

1 stop5h 56m

$142

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 10/24

7:52 pm-11:50 pm

1 stop5h 58m

San Diego

Sun 10/26

7:23 pm-9:32 am

1 stop12h 09m

$144

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Thu 10/23

7:52 pm-8:08 pm

1 stop26h 16m

San Diego

Wed 10/29

2:24 pm-9:07 am

1 stop16h 43m

$145

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 10/22

7:52 pm-11:50 pm

1 stop5h 58m

San Diego

Wed 10/29

2:24 pm-9:07 am

1 stop16h 43m

$149

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 9/19

9:35 pm-6:30 pm

1 stop22h 55m

San Diego

Mon 9/22

1:35 pm-9:06 am

2 stops17h 31m

$194

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 9/16

7:55 pm-11:34 pm

2 stops29h 39m

San Diego

Sat 9/20

8:00 am-4:03 pm

1 stop6h 03m

$198

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 10/1

6:10 am-2:03 pm

1 stop9h 53m

San Diego

Wed 10/8

8:18 am-6:36 pm

1 stop8h 18m

$268

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Thu 10/23

4:25 pm-6:20 pm

Nonstop3h 55m

San Diego

Wed 10/29

8:40 am-2:20 pm

Nonstop3h 40m

$272

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 12/24

2:04 pm-9:02 pm

1 stop8h 58m

San Diego

Wed 12/31

1:36 pm-11:55 pm

1 stop8h 19m

$273

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Thu 10/23

5:40 am-10:25 am

1 stop6h 45m

San Diego

Wed 10/29

8:40 am-2:20 pm

Nonstop3h 40m

$277

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from St. Louis to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of January, then departing from St. Louis during the month February is also very affordable. Most momondo users find prices during this month for around $333.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from St. Louis to San Diego is on a Tuesday. Travelers who choose to depart for San Diego on a Tuesday will often find tickets for as low as $480. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $621. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $501. Flights in the morning are often more expensive with an average ticket price of $587.

What is the cheapest Lambert-St Louis to San Diego flight route?

Fly from Lambert-St Louis to San Diego for the best Lambert-St Louis - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $361 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from St. Louis for as low as $313 on momondo.

What cabin class options are available on Lambert-St Louis to San Diego flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have St. Louis to San Diego flight prices changed over time?

As of September 2025, prices for St. Louis to San Diego flights are approximately 79% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to San Diego (STL to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to San Diego

Best Price Found

$263

Fastest flight time

3h 45m

Direct flights

Every day

Airports in San Diego

1 airport
The best one-way flight to San Diego from St. Louis in the past 72 hours is $263. The best round-trip flight deal from St. Louis to San Diego found on momondo in the last 72 hours is $400.
The fastest flight from St. Louis to San Diego takes 3h 45m
Direct flights go from St. Louis to San Diego every day.
There is 1 airport near San Diego: San Diego (SAN)
Search flight deals

  • How far is Lambert-St Louis to San Diego by plane?

    There are 1560.0 mi between Lambert-St Louis and San Diego. By plane, this route typically takes 3h 55m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to San Diego Airport?

    Prices for flights from Lambert-St Louis Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to San Diego Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents you'll need for your trip to San Diego Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Diego Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to San Diego?

  • What is the most popular airline from St. Louis to San Diego?

Best airlines flying from St. Louis to San Diego

Compare and see reviews for airlines that fly from St. Louis to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $108Free CancellationRating
5.8
3,198 reviews
Search Frontier flights
American AirlinesPriceFrom $233Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $256Free CancellationRating
7.4
8,937 reviews
Search United Airlines flights
DeltaPriceFrom $256Free CancellationRating
7.9
7,973 reviews
Search Delta flights
SouthwestPriceFrom $313Free CancellationRating
8.0
4,238 reviews
Search Southwest flights

  • Southwest Flights From St. Louis to San Diego

    The lowest priced Southwest flight from St. Louis to San Diego from the last 72 hours was $313. Generally, Southwest has 5 flights on this route every week with an average price of $493. Southwest is rated 8.0/10 by our users.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
La Mesa
National City
Imperial Beach
Poway
San Ysidro
Borrego Springs
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to San Diego?

Finding the right flight to San Diego from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Diego quick and easy, saving you time and money.

Can I find flights from St. Louis to San Diego with flexible booking policies on momondo?

Flights from St. Louis to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to San Diego?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from St. Louis to San Diego.

I’m not ready to book a flight from St. Louis to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from St. Louis. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your San Diego trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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