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Cheap flights from St. Louis to San Diego from $72

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to San Diego departing on 5/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from St. Louis to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:51 pm - 9:12 pm
STL
-
SAN
28h 21m
1 stop
Frontier Logo
9:37 am - 7:23 pm
SAN
-
STL
7h 46m
1 stop
$241Frontier
Wed, May 20 - Tue, May 26
Frontier Logo
6:51 pm - 6:39 pm
STL
-
SAN
25h 48m
1 stop
Frontier Logo
1:38 pm - 8:55 am
SAN
-
STL
17h 17m
2 stops
$243Frontier
Tue, May 5 - Sun, May 10
Frontier Logo
8:19 pm - 11:06 pm
STL
-
SAN
28h 47m
1 stop
Frontier Logo
6:25 am - 2:36 pm
SAN
-
STL
6h 11m
1 stop
$245Frontier
Mon, Apr 13 - Mon, Apr 20
Frontier Logo
3:33 pm - 6:33 pm
STL
-
SAN
29h 00m
1 stop
Frontier Logo
1:38 pm - 6:06 pm
SAN
-
STL
26h 28m
2 stops
$249Frontier
Thu, May 14 - Mon, May 18
Frontier Logo
8:08 pm - 11:53 pm
STL
-
SAN
5h 45m
1 stop
Frontier Logo
6:25 am - 7:23 pm
SAN
-
STL
10h 58m
1 stop
$250Frontier
Thu, Aug 27 - Sun, Aug 30
Frontier Logo
8:21 pm - 8:58 pm
STL
-
SAN
26h 37m
1 stop
Frontier Logo
9:53 pm - 6:08 pm
SAN
-
STL
18h 15m
1 stop
$253Frontier
Mon, Jun 29 - Tue, Jul 14
Frontier Logo
8:39 am - 11:29 pm
STL
-
SAN
16h 50m
1 stop
Frontier Logo
8:38 am - 11:19 pm
SAN
-
STL
36h 41m
2 stops
$254Frontier
Fri, Apr 24 - Mon, Apr 27
Frontier Logo
9:55 pm - 8:34 am
STL
-
SAN
12h 39m
2 stops
Frontier Logo
6:25 am - 7:32 pm
SAN
-
STL
11h 07m
1 stop
$255Frontier
Thu, Apr 30 - Mon, May 4
Frontier Logo
8:06 pm - 11:06 pm
STL
-
SAN
29h 00m
1 stop
Frontier Logo
9:00 pm - 9:00 pm
SAN
-
STL
22h 00m
1 stop
$256Frontier
Fri, Apr 17 - Sun, Apr 19
Frontier Logo
8:08 pm - 11:50 pm
STL
-
SAN
29h 42m
1 stop
Frontier Logo
10:07 pm - 7:23 pm
SAN
-
STL
43h 16m
2 stops
$258Frontier
Fri, May 29 - Thu, Jun 4

Frontier flights from St. Louis to San Diego

Our best Frontier deals on St. Louis to San Diego flight tickets
Frontier
May 20
STL6:51 pmLambert-St Louis
28h 21m
1 stop
SAN9:12 pmSan Diego
May 26
SAN9:37 amSan Diego
7h 46m
1 stop
STL7:23 pmLambert-St Louis
$241
Frontier
May 5
STL6:51 pmLambert-St Louis
25h 48m
1 stop
SAN6:39 pmSan Diego
May 10
SAN1:38 pmSan Diego
17h 17m
2 stops
STL8:55 amLambert-St Louis
$243
Frontier
Apr 13
STL8:19 pmLambert-St Louis
28h 47m
1 stop
SAN11:06 pmSan Diego
Apr 20
SAN6:25 amSan Diego
6h 11m
1 stop
STL2:36 pmLambert-St Louis
$245

Delta flights from St. Louis to San Diego

Our best Delta deals on St. Louis to San Diego flight tickets
Delta
May 20
STL5:36 pmLambert-St Louis
8h 05m
1 stop
SAN11:41 pmSan Diego
May 25
SAN6:30 amSan Diego
8h 16m
1 stop
STL4:46 pmLambert-St Louis
$297
Delta
Apr 10
STL5:25 pmLambert-St Louis
8h 15m
1 stop
SAN11:40 pmSan Diego
Apr 14
SAN5:00 pmSan Diego
5h 25m
1 stop
STL12:25 amLambert-St Louis
$352

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from St. Louis to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 5/20

6:51 pm-9:12 pm

1 stop28h 21m

San Diego

Tue 5/26

9:37 am-7:23 pm

1 stop7h 46m

$241

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 5/5

6:51 pm-6:39 pm

1 stop25h 48m

San Diego

Sun 5/10

1:38 pm-8:55 am

2 stops17h 17m

$243

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Mon 4/13

8:19 pm-11:06 pm

1 stop28h 47m

San Diego

Mon 4/20

6:25 am-2:36 pm

1 stop6h 11m

$245

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Thu 5/14

3:33 pm-6:33 pm

1 stop29h 00m

San Diego

Mon 5/18

1:38 pm-6:06 pm

2 stops26h 28m

$249
Quickest round-trip

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Thu 8/27

8:08 pm-11:53 pm

1 stop5h 45m

San Diego

Sun 8/30

6:25 am-7:23 pm

1 stop10h 58m

$250

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Mon 6/29

8:21 pm-8:58 pm

1 stop26h 37m

San Diego

Tue 7/14

9:53 pm-6:08 pm

1 stop18h 15m

$253

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 4/24

8:39 am-11:29 pm

1 stop16h 50m

San Diego

Mon 4/27

8:38 am-11:19 pm

2 stops36h 41m

$254

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Thu 4/30

9:55 pm-8:34 am

2 stops12h 39m

San Diego

Mon 5/4

6:25 am-7:32 pm

1 stop11h 07m

$255

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 4/17

8:06 pm-11:06 pm

1 stop29h 00m

San Diego

Sun 4/19

9:00 pm-9:00 pm

1 stop22h 00m

$256

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 5/29

8:08 pm-11:50 pm

1 stop29h 42m

San Diego

Thu 6/4

10:07 pm-7:23 pm

2 stops43h 16m

$258

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Diego from

How to get the cheapest flight ticket from St. Louis to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and San Diego?

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from St. Louis during the month September is also very affordable. Most momondo users find prices during this month for around $341.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from St. Louis to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $412. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $567. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $438. Flights at noon are often more expensive with an average ticket price of $566.

What is the cheapest Lambert-St Louis to San Diego flight route?

Fly from Lambert-St Louis to San Diego for the best Lambert-St Louis - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $390 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from St. Louis for as low as $321 on momondo.

What cabin class options are available on Lambert-St Louis to San Diego flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have St. Louis to San Diego flight prices changed over time?

As of April 2026, prices for St. Louis to San Diego flights are approximately 1% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to San Diego (STL to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to San Diego

Best Price Found

$283

Fastest flight time

3h 40m

Direct flights

Every day

Airports in San Diego

1 airport
The best one-way flight to San Diego from St. Louis in the past 72 hours is $283. The best round-trip flight deal from St. Louis to San Diego found on momondo in the last 72 hours is $449.
The fastest flight from St. Louis to San Diego takes 3h 40m
Direct flights go from St. Louis to San Diego every day.
There is 1 airport in San Diego. From St. Louis there are direct flights to San Diego (SAN).
Search flight deals

Frequently asked questions about flying from St. Louis to San Diego

  • How far is Lambert-St Louis to San Diego by plane?

    There are 1560.0 mi between Lambert-St Louis and San Diego. By plane, this route typically takes 3h 40m.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to San Diego Airport?

    Prices for flights from Lambert-St Louis Airport to San Diego Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to San Diego Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents you'll need for your trip to San Diego Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Diego Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to San Diego?

  • What is the most popular airline from St. Louis to San Diego?

Best airlines flying from St. Louis to San Diego

Compare and see reviews for airlines that fly from St. Louis to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $88Free CancellationRating
5.7
3,000 reviews
Search Frontier flights
United AirlinesPriceFrom $182Free CancellationRating
7.4
9,538 reviews
Search United Airlines flights
American AirlinesPriceFrom $210Free CancellationRating
7.1
11,551 reviews
Search American Airlines flights
DeltaPriceFrom $232Free CancellationRating
7.9
8,374 reviews
Search Delta flights
SouthwestPriceFrom $283Free CancellationRating
8.0
4,344 reviews
Search Southwest flights

  • Southwest Flights From St. Louis to San Diego

    The lowest priced Southwest flight from St. Louis to San Diego from the last 72 hours was $283. Generally, Southwest has 3 flights on this route every week with an average price of $458. Southwest is rated 8.0/10 by our users.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
San Ysidro
La Mesa
Imperial Beach
Borrego Springs
Alpine
Santee
Lemon Grove

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to San Diego?

Finding the right flight to San Diego from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Diego quick and easy, saving you time and money.

Can I find flights from St. Louis to San Diego with flexible booking policies on momondo?

Flights from St. Louis to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to San Diego?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from St. Louis to San Diego.

I’m not ready to book a flight from St. Louis to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from St. Louis. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your San Diego trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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