Cheap flights from Portland to Los Angeles from $72

The cheapest month to fly to Santa Ana from Portland is in September. Flight prices, which tend to average around $247, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Santa Ana, with average flight prices from Portland averaging around $257.

On average, the least expensive day to fly to Santa Ana from Portland is on a Saturday. momondo users have found tickets for Saturday departures for as low as $271. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Monday is the most expensive day to depart from Portland because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $335.

Our data shows that the cheapest Portland to Santa Ana flights are usually those with departure times in the evening. Our users have found flights to Santa Ana in the evening for as low as $277. Try not to purchase tickets in the afternoon because they tend to be around $327. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Portland to Santa Ana J. Wayne/Orange Cnty for the best Portland - Santa Ana J. Wayne/Orange Cnty flight prices

You are more likely to see cheaper flights to Santa Ana from Portland when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana for around $301 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana from Portland for as low as $250 on momondo.

There are 4 cabin classes available to choose from on Portland to Santa Ana J. Wayne/Orange Cnty flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 29% on your flight if you consider stops on a Portland to Santa Ana flight.

As of February 2026, prices for Portland to Santa Ana flights are approximately 94% more expensive when compared to flights at the same time last year.

Delta, Southwest, and United Airlines are the most popular carriers operating from Portland to Santa Ana J. Wayne/Orange Cnty

Alaska Airlines, Frontier and Delta are the top three most popular airlines that fly to Santa Ana from Portland according to our data. Alaska Airlines is the first choice among our users, with 51% of people opting to fly with this airline when traveling to Santa Ana. Keep in mind that there are 9 different airlines that fly to Santa Ana on a routine basis, so you have a few additional options to choose from.

8 flights are operational daily from Portland to Santa Ana as of February 2026. The most popular departure time for this route is 2:00PM, with 54% of flights per day taking off at noon.

The number of flights available between Portland and Santa Ana is 59 per week as of February 2026. The most frequent departure day is Mon, with 17% of weekly flights leaving on this day.