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Cheap flights from Myrtle Beach to San Diego from $131

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to San Diego departing on 1/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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Delta Logo
4:00 pm - 10:45 pm
MYR
-
SAN
9h 45m1 stop
Delta Logo
2:20 pm - 11:41 pm
SAN
-
MYR
6h 21m1 stop
$337Delta
Sat, Jan 17 - Sat, Jan 24
Delta Logo
6:00 am - 9:58 am
MYR
-
SAN
6h 58m1 stop
Delta Logo
10:30 pm - 9:46 am
SAN
-
MYR
8h 16m1 stop
$340Delta
Tue, Jan 13 - Tue, Jan 20
American Airlines Logo
12:05 pm - 6:31 pm
MYR
-
SAN
9h 26m2 stops
American Airlines Logo
6:20 am - 5:04 pm
SAN
-
MYR
7h 44m1 stop
$342American Airlines
Sat, Jan 17 - Sat, Jan 24
United Airlines Logo
1:25 pm - 11:42 pm
MYR
-
SAN
13h 17m2 stops
United Airlines Logo
10:40 pm - 12:41 pm
SAN
-
MYR
11h 01m1 stop
$345United Airlines
Tue, Jan 13 - Tue, Jan 20
American Airlines Logo
6:23 am - 3:03 pm
MYR
-
SAN
11h 40m2 stops
American Airlines Logo
7:10 am - 8:54 pm
SAN
-
MYR
10h 44m2 stops
$347American Airlines
Sat, Jan 17 - Sat, Jan 24
United Airlines Logo
1:25 pm - 11:42 pm
MYR
-
SAN
13h 17m2 stops
United Airlines Logo
6:00 pm - 12:41 pm
SAN
-
MYR
15h 41m2 stops
$350United Airlines
Tue, Jan 13 - Tue, Jan 20
American Airlines Logo
6:09 pm - 10:50 pm
MYR
-
SAN
7h 41m1 stop
American Airlines Logo
10:45 pm - 9:48 am
SAN
-
MYR
8h 03m1 stop
$367American Airlines
Thu, Jan 15 - Thu, Jan 22
Southwest Logo
1:20 pm - 9:10 pm
MYR
-
SAN
10h 50m2 stops
Southwest Logo
9:45 pm - 10:15 am
SAN
-
MYR
9h 30m1 stop
$372Southwest
Thu, Jan 15 - Thu, Jan 22
Southwest Logo
1:20 pm - 8:00 pm
MYR
-
SAN
9h 40m2 stops
Southwest Logo
6:20 am - 7:45 pm
SAN
-
MYR
10h 25m2 stops
$377Southwest
Thu, Jan 15 - Thu, Jan 22
Southwest Logo
8:15 am - 3:25 pm
MYR
-
SAN
10h 10m2 stops
Southwest Logo
7:05 am - 9:05 pm
SAN
-
MYR
11h 00m2 stops
$403Southwest
Wed, Jan 21 - Sun, Jan 25

Delta flights from Myrtle Beach to San Diego

Our best Delta deals on Myrtle Beach to San Diego flight tickets
Delta
Jan 17
MYR4:00 pmMyrtle Beach Intl
9h 45m
1 stop
SAN10:45 pmSan Diego
Jan 24
SAN2:20 pmSan Diego
6h 21m
1 stop
MYR11:41 pmMyrtle Beach Intl
$337
Find similar
Delta
Dec 31
MYR11:27 amMyrtle Beach Intl
10h 14m
1 stop
SAN6:41 pmSan Diego
Jan 4
SAN9:45 pmSan Diego
9h 01m
1 stop
MYR9:46 amMyrtle Beach Intl
$473
Find similar
Delta
Jan 2
MYR11:09 amMyrtle Beach Intl
7h 12m
1 stop
SAN3:21 pmSan Diego
Jan 6
SAN10:30 pmSan Diego
8h 16m
1 stop
MYR9:46 amMyrtle Beach Intl
$613
Find similar

Southwest flights from Myrtle Beach to San Diego

Our best Southwest deals on Myrtle Beach to San Diego flight tickets
Southwest
Jan 13
MYR3:00 pmMyrtle Beach Intl
10h 20m
1 stop
SAN10:20 pmSan Diego
Jan 20
SAN7:25 amSan Diego
6h 35m
1 stop
MYR5:00 pmMyrtle Beach Intl
$340
Find similar
Southwest
Jan 15
MYR1:20 pmMyrtle Beach Intl
10h 50m
2 stops
SAN9:10 pmSan Diego
Jan 22
SAN9:45 pmSan Diego
9h 30m
1 stop
MYR10:15 amMyrtle Beach Intl
$372
Find similar
Southwest
Jan 15
MYR1:20 pmMyrtle Beach Intl
9h 40m
2 stops
SAN8:00 pmSan Diego
Jan 22
SAN6:20 amSan Diego
10h 25m
2 stops
MYR7:45 pmMyrtle Beach Intl
$377
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Myrtle Beach to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sat 1/17

4:00 pm-10:45 pm

1 stop9h 45m

San Diego

Sat 1/24

2:20 pm-11:41 pm

1 stop6h 21m

$337

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 1/13

6:00 am-9:58 am

1 stop6h 58m

San Diego

Tue 1/20

10:30 pm-9:46 am

1 stop8h 16m

$340

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sat 1/17

12:05 pm-6:31 pm

2 stops9h 26m

San Diego

Sat 1/24

6:20 am-5:04 pm

1 stop7h 44m

$342

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 1/13

1:25 pm-11:42 pm

2 stops13h 17m

San Diego

Tue 1/20

10:40 pm-12:41 pm

1 stop11h 01m

$345

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sat 1/17

6:23 am-3:03 pm

2 stops11h 40m

San Diego

Sat 1/24

7:10 am-8:54 pm

2 stops10h 44m

$347

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 1/13

1:25 pm-11:42 pm

2 stops13h 17m

San Diego

Tue 1/20

6:00 pm-12:41 pm

2 stops15h 41m

$350

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 1/15

6:09 pm-10:50 pm

1 stop7h 41m

San Diego

Thu 1/22

10:45 pm-9:48 am

1 stop8h 03m

$367

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 1/15

1:20 pm-9:10 pm

2 stops10h 50m

San Diego

Thu 1/22

9:45 pm-10:15 am

1 stop9h 30m

$372

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 1/15

1:20 pm-8:00 pm

2 stops9h 40m

San Diego

Thu 1/22

6:20 am-7:45 pm

2 stops10h 25m

$377

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Wed 1/21

8:15 am-3:25 pm

2 stops10h 10m

San Diego

Sun 1/25

7:05 am-9:05 pm

2 stops11h 00m

$403

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Myrtle Beach to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Myrtle Beach and San Diego?

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of September, then departing from Myrtle Beach during the month May is also very affordable. Most momondo users find prices during this month for around $384.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Myrtle Beach to San Diego is on a Tuesday. Travelers who choose to depart for San Diego on a Tuesday will often find tickets for as low as $428. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $597. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $454. Flights in the afternoon are often more expensive with an average ticket price of $520.

How have Myrtle Beach to San Diego flight prices changed over time?

As of December 2025, prices for Myrtle Beach to San Diego flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from Myrtle Beach to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to San Diego (MYR to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to San Diego

Fastest flight time

6h 58m

Direct flights

None
The fastest flight from Myrtle Beach to San Diego takes 6h 58m
There are no direct flights from Myrtle Beach to San Diego. There are no popular flight routes from Myrtle Beach to San Diego.
Search flight deals

  • How far is Myrtle Beach Intl to San Diego by plane?

    The distance between Myrtle Beach Intl and San Diego is about 2199.3 mi. A reasonable flight in good conditions will take 6h 58m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to San Diego Airport?

    Prices for flights from Myrtle Beach Intl Airport to San Diego Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to San Diego Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to San Diego?

Best airlines flying from Myrtle Beach to San Diego

Compare and see reviews for airlines that fly from Myrtle Beach to San Diego with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $274Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
DeltaPriceFrom $331Free CancellationRating
7.9
8,005 reviews
Search Delta flights
SouthwestPriceFrom $437Free CancellationRating
7.9
4,250 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
Imperial Beach
Borrego Springs
La Mesa
San Ysidro
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Myrtle Beach to San Diego for you.

Can I find flights from Myrtle Beach to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to San Diego?

Once all potential Myrtle Beach to San Diego flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to San Diego right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to San Diego now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to San Diego and let you know when they change.

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