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Cheap flights from Myrtle Beach to San Diego from $154

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to San Diego departing on 3/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Myrtle Beach to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:40 pm - 12:11 am
MYR
-
SAN
34h 31m
2 stops
Multiple Airlines Logo
12:33 pm - 8:41 pm
SAN
-
MYR
29h 08m
1 stop
$335Multiple Airlines
Sat, May 2 - Fri, May 8
Multiple Airlines Logo
7:51 pm - 12:11 am
MYR
-
SAN
31h 20m
2 stops
Multiple Airlines Logo
12:33 pm - 7:06 pm
SAN
-
MYR
27h 33m
1 stop
$358Multiple Airlines
Wed, May 13 - Mon, May 18
Southwest Logo
4:05 pm - 9:20 pm
MYR
-
SAN
8h 15m
1 stop
Southwest Logo
9:40 pm - 10:35 am
SAN
-
MYR
9h 55m
1 stop
$378Southwest
Wed, May 13 - Mon, May 18
Southwest Logo
3:45 pm - 10:55 pm
MYR
-
SAN
10h 10m
1 stop
Southwest Logo
6:20 am - 8:35 pm
SAN
-
MYR
11h 15m
1 stop
$379Southwest
Thu, Apr 23 - Tue, Apr 28
Multiple Airlines Logo
3:20 pm - 11:48 am
MYR
-
SAN
23h 28m
1 stop
Multiple Airlines Logo
6:55 am - 9:42 am
SAN
-
MYR
23h 47m
2 stops
$382Multiple Airlines
Thu, May 14 - Sun, May 17
American Airlines Logo
6:01 am - 1:28 pm
MYR
-
SAN
10h 27m
1 stop
American Airlines Logo
10:00 pm - 8:32 am
SAN
-
MYR
7h 32m
1 stop
$383American Airlines
Tue, Mar 10 - Thu, Mar 12
Southwest Logo
3:45 pm - 11:05 pm
MYR
-
SAN
10h 20m
2 stops
Southwest Logo
6:35 am - 5:35 pm
SAN
-
MYR
8h 00m
2 stops
$384Southwest
Thu, Apr 23 - Tue, Apr 28
American Airlines Logo
10:26 am - 6:04 pm
MYR
-
SAN
10h 38m
2 stops
American Airlines Logo
10:00 pm - 8:32 am
SAN
-
MYR
7h 32m
1 stop
$388American Airlines
Tue, Mar 10 - Thu, Mar 12
Southwest Logo
1:45 pm - 7:00 pm
MYR
-
SAN
8h 15m
1 stop
Southwest Logo
9:40 pm - 10:35 am
SAN
-
MYR
9h 55m
1 stop
$389Southwest
Thu, Apr 30 - Mon, May 4
American Airlines Logo
10:26 am - 6:04 pm
MYR
-
SAN
10h 38m
2 stops
American Airlines Logo
7:52 pm - 8:32 am
SAN
-
MYR
9h 40m
2 stops
$393American Airlines
Tue, Mar 10 - Thu, Mar 12

Southwest flights from Myrtle Beach to San Diego

Our best Southwest deals on Myrtle Beach to San Diego flight tickets
Southwest
May 13
MYR4:05 pmMyrtle Beach Intl
8h 15m
1 stop
SAN9:20 pmSan Diego
May 18
SAN9:40 pmSan Diego
9h 55m
1 stop
MYR10:35 amMyrtle Beach Intl
$378
Southwest
Apr 23
MYR3:45 pmMyrtle Beach Intl
10h 10m
1 stop
SAN10:55 pmSan Diego
Apr 28
SAN6:35 amSan Diego
8h 00m
2 stops
MYR5:35 pmMyrtle Beach Intl
$379
Southwest
Apr 23
MYR3:45 pmMyrtle Beach Intl
10h 20m
2 stops
SAN11:05 pmSan Diego
Apr 28
SAN6:35 amSan Diego
8h 00m
2 stops
MYR5:35 pmMyrtle Beach Intl
$384

United Airlines flights from Myrtle Beach to San Diego

Our best United Airlines deals on Myrtle Beach to San Diego flight tickets
United Airlines
Apr 30
MYR3:14 pmMyrtle Beach Intl
10h 20m
1 stop
SAN10:34 pmSan Diego
May 4
SAN7:00 pmSan Diego
13h 04m
2 stops
MYR11:04 amMyrtle Beach Intl
$394
United Airlines
Apr 30
MYR3:14 pmMyrtle Beach Intl
11h 45m
2 stops
SAN11:59 pmSan Diego
May 4
SAN8:45 pmSan Diego
11h 19m
2 stops
MYR11:04 amMyrtle Beach Intl
$399
United Airlines
Apr 24
MYR3:15 pmMyrtle Beach Intl
10h 44m
1 stop
SAN10:59 pmSan Diego
Apr 28
SAN10:30 pmSan Diego
8h 48m
1 stop
MYR10:18 amMyrtle Beach Intl
$407

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from Myrtle Beach to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sat 5/2

4:40 pm-12:11 am

2 stops34h 31m

San Diego

Fri 5/8

12:33 pm-8:41 pm

1 stop29h 08m

$335

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Wed 5/13

7:51 pm-12:11 am

2 stops31h 20m

San Diego

Mon 5/18

12:33 pm-7:06 pm

1 stop27h 33m

$358

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Wed 5/13

4:05 pm-9:20 pm

1 stop8h 15m

San Diego

Mon 5/18

9:40 pm-10:35 am

1 stop9h 55m

$378

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 4/23

3:45 pm-10:55 pm

1 stop10h 10m

San Diego

Tue 4/28

6:20 am-8:35 pm

1 stop11h 15m

$379

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 5/14

3:20 pm-11:48 am

1 stop23h 28m

San Diego

Sun 5/17

6:55 am-9:42 am

2 stops23h 47m

$382

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 3/10

6:01 am-1:28 pm

1 stop10h 27m

San Diego

Thu 3/12

10:00 pm-8:32 am

1 stop7h 32m

$383

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 4/23

3:45 pm-11:05 pm

2 stops10h 20m

San Diego

Tue 4/28

6:35 am-5:35 pm

2 stops8h 00m

$384

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 3/10

10:26 am-6:04 pm

2 stops10h 38m

San Diego

Thu 3/12

10:00 pm-8:32 am

1 stop7h 32m

$388

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 4/30

1:45 pm-7:00 pm

1 stop8h 15m

San Diego

Mon 5/4

9:40 pm-10:35 am

1 stop9h 55m

$389

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 3/10

10:26 am-6:04 pm

2 stops10h 38m

San Diego

Thu 3/12

7:52 pm-8:32 am

2 stops9h 40m

$393

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Myrtle Beach to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of September, then departing from Myrtle Beach during the month May is also very affordable. Most momondo users find prices during this month for around $382.

How have Myrtle Beach to San Diego flight prices changed over time?

As of February 2026, prices for Myrtle Beach to San Diego flights are approximately 45% more expensive when compared to flights at the same time last year.

When to book flights from Myrtle Beach to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to San Diego (MYR to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to San Diego

Fastest flight time

7h 01m

Direct flights

None
The fastest flight from Myrtle Beach to San Diego takes 7h 01m
There are no direct flights from Myrtle Beach to San Diego. There are no popular flight routes from Myrtle Beach to San Diego.
Search flight deals

  • How far is Myrtle Beach Intl to San Diego by plane?

    The distance between Myrtle Beach Intl and San Diego is about 2199.3 mi. A reasonable flight in good conditions will take 7h 01m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to San Diego Airport?

    Prices for flights from Myrtle Beach Intl Airport to San Diego Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to San Diego Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to San Diego?

Best airlines flying from Myrtle Beach to San Diego

Compare and see reviews for airlines that fly from Myrtle Beach to San Diego with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $274Free CancellationRating
7.2
11,258 reviews
Search American Airlines flights
DeltaPriceFrom $331Free CancellationRating
7.9
8,174 reviews
Search Delta flights
SouthwestPriceFrom $437Free CancellationRating
8.0
4,282 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
Poway
National City
Imperial Beach
San Ysidro
Borrego Springs
La Mesa
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Myrtle Beach to San Diego for you.

Can I find flights from Myrtle Beach to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to San Diego?

Once all potential Myrtle Beach to San Diego flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to San Diego right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to San Diego now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to San Diego and let you know when they change.

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