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Cheap flights from Myrtle Beach to San Diego from $180

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to San Diego departing on 12/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Delta Logo
4:00 pm - 10:47 pmMYR-SAN
9h 47m1 stop
Delta Logo
10:30 pm - 9:48 amSAN-MYR
8h 18m1 stop
$359Delta
Find Deal
Tue, Jan 13 - Tue, Jan 20
Delta Logo
4:00 pm - 10:47 pmMYR-SAN
9h 47m1 stop
Delta Logo
10:30 pm - 9:48 amSAN-MYR
8h 18m1 stop
$363Delta
Find Deal
Tue, Jan 13 - Tue, Jan 20
American Airlines Logo
10:18 am - 6:31 pmMYR-SAN
11h 13m2 stops
American Airlines Logo
10:45 pm - 9:48 amSAN-MYR
8h 03m1 stop
$364American Airlines
Find Deal
Tue, Jan 13 - Tue, Jan 20
American Airlines Logo
5:44 pm - 10:50 pmMYR-SAN
8h 06m1 stop
American Airlines Logo
10:45 pm - 9:48 amSAN-MYR
8h 03m1 stop
$367American Airlines
Find Deal
Tue, Jan 13 - Tue, Jan 20
American Airlines Logo
1:53 pm - 8:36 pmMYR-SAN
9h 43m1 stop
American Airlines Logo
9:21 am - 8:54 pmSAN-MYR
8h 33m2 stops
$368American Airlines
Find Deal
Tue, Jan 13 - Tue, Jan 20
Southwest Logo
10:40 am - 6:40 pmMYR-SAN
11h 00m2 stops
Southwest Logo
6:40 am - 9:10 pmSAN-MYR
11h 30m2 stops
$457Southwest
Find Deal
Tue, Mar 10 - Tue, Mar 17
Alaska Airlines Logo
12:41 pm - 11:59 pmMYR-SAN
14h 18m2 stops
Alaska Airlines Logo
6:55 am - 10:07 amSAN-MYR
24h 12m3 stops
$604Alaska Airlines
Find Deal
Sun, Dec 7 - Mon, Dec 15
Alaska Airlines Logo
4:05 pm - 10:13 amMYR-SAN
21h 08m2 stops
Alaska Airlines Logo
10:55 am - 10:07 amSAN-MYR
20h 12m3 stops
$635Alaska Airlines
Find Deal
Sun, Dec 7 - Mon, Dec 15
Southwest Logo
10:45 am - 3:20 pmMYR-SAN
7h 35m1 stop
Southwest Logo
9:35 pm - 12:05 pmSAN-MYR
11h 30m2 stops
$753Southwest
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Tue, Nov 11 - Sat, Nov 22
United Airlines Logo
12:42 pm - 11:37 pmMYR-SAN
13h 55m2 stops
United Airlines Logo
9:30 pm - 12:01 pmSAN-MYR
11h 31m2 stops
$803United Airlines
Find Deal
Sat, Dec 20 - Fri, Jan 2

Delta flights from Myrtle Beach to San Diego

Our best Delta deals on Myrtle Beach to San Diego flight tickets
Delta
Jan 13
MYR4:00 pmMyrtle Beach Intl
9h 47m
1 stop
SAN10:47 pmSan Diego
Jan 20
SAN10:30 pmSan Diego
8h 18m
1 stop
MYR9:48 amMyrtle Beach Intl
$359
Find similar
Delta
Jan 13
MYR4:00 pmMyrtle Beach Intl
9h 47m
1 stop
SAN10:47 pmSan Diego
Jan 20
SAN10:30 pmSan Diego
8h 18m
1 stop
MYR9:48 amMyrtle Beach Intl
$363
Find similar
Delta
Dec 7
MYR6:56 pmMyrtle Beach Intl
7h 39m
1 stop
SAN11:35 pmSan Diego
Dec 15
SAN10:00 pmSan Diego
9h 34m
1 stop
MYR10:34 amMyrtle Beach Intl
$412
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American Airlines flights from Myrtle Beach to San Diego

Our best American Airlines deals on Myrtle Beach to San Diego flight tickets
American Airlines
Jan 13
MYR10:18 amMyrtle Beach Intl
11h 13m
2 stops
SAN6:31 pmSan Diego
Jan 20
SAN10:45 pmSan Diego
8h 03m
1 stop
MYR9:48 amMyrtle Beach Intl
$364
Find similar
American Airlines
Jan 13
MYR5:44 pmMyrtle Beach Intl
8h 06m
1 stop
SAN10:50 pmSan Diego
Jan 20
SAN10:45 pmSan Diego
8h 03m
1 stop
MYR9:48 amMyrtle Beach Intl
$367
Find similar
American Airlines
Jan 13
MYR1:53 pmMyrtle Beach Intl
9h 43m
1 stop
SAN8:36 pmSan Diego
Jan 20
SAN9:21 amSan Diego
8h 33m
2 stops
MYR8:54 pmMyrtle Beach Intl
$368
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 1, 2025.
Use the filters below to find and compare flights from Myrtle Beach to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 1/13

4:00 pm-10:47 pm

1 stop9h 47m

San Diego

Tue 1/20

10:30 pm-9:48 am

1 stop8h 18m

$359

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 1/13

4:00 pm-10:47 pm

1 stop9h 47m

San Diego

Tue 1/20

10:30 pm-9:48 am

1 stop8h 18m

$363

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 1/13

10:18 am-6:31 pm

2 stops11h 13m

San Diego

Tue 1/20

10:45 pm-9:48 am

1 stop8h 03m

$364

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 1/13

5:44 pm-10:50 pm

1 stop8h 06m

San Diego

Tue 1/20

10:45 pm-9:48 am

1 stop8h 03m

$367

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 1/13

1:53 pm-8:36 pm

1 stop9h 43m

San Diego

Tue 1/20

9:21 am-8:54 pm

2 stops8h 33m

$368

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 3/10

10:40 am-6:40 pm

2 stops11h 00m

San Diego

Tue 3/17

6:40 am-9:10 pm

2 stops11h 30m

$457

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sun 12/7

12:41 pm-11:59 pm

2 stops14h 18m

San Diego

Mon 12/15

6:55 am-10:07 am

3 stops24h 12m

$604

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sun 12/7

4:05 pm-10:13 am

2 stops21h 08m

San Diego

Mon 12/15

10:55 am-10:07 am

3 stops20h 12m

$635

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 11/11

10:45 am-3:20 pm

1 stop7h 35m

San Diego

Sat 11/22

9:35 pm-12:05 pm

2 stops11h 30m

$753

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sat 12/20

12:42 pm-11:37 pm

2 stops13h 55m

San Diego

Fri 1/2

9:30 pm-12:01 pm

2 stops11h 31m

$803

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Myrtle Beach to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Myrtle Beach and San Diego?

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of September, then departing from Myrtle Beach during the month May is also very affordable. Most momondo users find prices during this month for around $384.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Myrtle Beach to San Diego is on a Tuesday. Travelers who choose to depart for San Diego on a Tuesday will often find tickets for as low as $428. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $597. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $454. Flights in the afternoon are often more expensive with an average ticket price of $520.

How have Myrtle Beach to San Diego flight prices changed over time?

As of November 2025, prices for Myrtle Beach to San Diego flights are approximately 25% more expensive when compared to flights at the same time last year.

When to book flights from Myrtle Beach to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to San Diego (MYR to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to San Diego

Direct flights

None
There are no direct flights from Myrtle Beach to San Diego. There are no popular flight routes from Myrtle Beach to San Diego.
Search flight deals

  • How far is Myrtle Beach Intl to San Diego by plane?

    The distance between Myrtle Beach Intl and San Diego is about 2199.3 mi. A reasonable flight in good conditions will take 7h 29m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to San Diego Airport?

    Prices for flights from Myrtle Beach Intl Airport to San Diego Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to San Diego Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to San Diego?

Best airlines flying from Myrtle Beach to San Diego

Compare and see reviews for airlines that fly from Myrtle Beach to San Diego with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $296Free CancellationRating
7.2
11,033 reviews
Search American Airlines flights
DeltaPriceFrom $331Free CancellationRating
7.9
7,997 reviews
Search Delta flights
SouthwestPriceFrom $437Free CancellationRating
8.0
4,241 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
La Mesa
Imperial Beach
Poway
Borrego Springs
San Ysidro
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Myrtle Beach to San Diego for you.

Can I find flights from Myrtle Beach to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to San Diego?

Once all potential Myrtle Beach to San Diego flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to San Diego right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to San Diego now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to San Diego and let you know when they change.

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