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Cheap flights from Myrtle Beach to San Diego from $148

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to San Diego departing on 10/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Myrtle Beach to San Diego (MYR-SAN)

Cheap round-trip flights

American Airlines Logo
7:00 am - 12:04 pmMYR-SAN
8h 04m1 stop
American Airlines Logo
10:31 pm - 9:37 amSAN-MYR
8h 06m1 stop
$295American Airlines
Find Deal
Tue, Oct 21 - Tue, Oct 28
American Airlines Logo
7:00 am - 12:29 pmMYR-SAN
8h 29m1 stop
American Airlines Logo
10:46 am - 10:54 pmSAN-MYR
9h 08m2 stops
$300American Airlines
Find Deal
Tue, Oct 21 - Tue, Oct 28
Southwest Logo
7:45 am - 5:50 pmMYR-SAN
13h 05m1 stop
Southwest Logo
6:35 am - 5:15 pmSAN-MYR
7h 40m1 stop
$318Southwest
Find Deal
Thu, Oct 9 - Mon, Oct 13
Delta Logo
11:29 am - 6:20 pmMYR-SAN
9h 51m1 stop
Delta Logo
10:00 pm - 10:34 amSAN-MYR
9h 34m1 stop
$332Delta
Find Deal
Tue, Dec 2 - Mon, Dec 15
Delta Logo
6:56 pm - 11:46 pmMYR-SAN
7h 50m1 stop
Delta Logo
10:00 pm - 10:34 amSAN-MYR
9h 34m1 stop
$358Delta
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Tue, Dec 2 - Sun, Dec 7
Southwest Logo
7:45 am - 5:50 pmMYR-SAN
13h 05m1 stop
Southwest Logo
6:35 am - 11:30 pmSAN-MYR
13h 55m1 stop
$391Southwest
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Thu, Oct 9 - Sun, Oct 12
United Airlines Logo
4:33 pm - 9:12 amMYR-SAN
19h 39m2 stops
United Airlines Logo
10:30 pm - 1:09 pmSAN-MYR
11h 39m2 stops
$460United Airlines
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Tue, Oct 21 - Tue, Oct 28
United Airlines Logo
5:37 pm - 9:12 amMYR-SAN
18h 35m2 stops
United Airlines Logo
7:50 pm - 1:09 pmSAN-MYR
14h 19m2 stops
$465United Airlines
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Tue, Oct 21 - Tue, Oct 28
Logo
11:36 am - 11:03 amMYR-SAN
26h 27m1 stop
Logo
6:35 am - 8:44 amSAN-MYR
23h 09m2 stops
$483
Find Deal
Thu, Sep 18 - Sun, Sep 21
Logo
11:36 am - 11:03 amMYR-SAN
26h 27m1 stop
Logo
6:15 am - 8:44 amSAN-MYR
23h 29m2 stops
$529
Find Deal
Sun, Sep 14 - Tue, Sep 16

Southwest flights from Myrtle Beach to San Diego

Our best Southwest deals on Myrtle Beach to San Diego flight tickets
Southwest
Oct 9
MYR7:45 amMyrtle Beach Intl
13h 05m
1 stop
SAN5:50 pmSan Diego
Oct 13
SAN6:35 amSan Diego
7h 40m
1 stop
MYR5:15 pmMyrtle Beach Intl
$318
Find similar
Southwest
Oct 9
MYR7:45 amMyrtle Beach Intl
13h 05m
1 stop
SAN5:50 pmSan Diego
Oct 12
SAN6:35 amSan Diego
13h 55m
1 stop
MYR11:30 pmMyrtle Beach Intl
$391
Find similar
Southwest
Oct 9
MYR7:45 amMyrtle Beach Intl
13h 05m
1 stop
SAN5:50 pmSan Diego
Oct 12
SAN6:35 amSan Diego
11h 50m
2 stops
MYR9:25 pmMyrtle Beach Intl
$401
Find similar

Delta flights from Myrtle Beach to San Diego

Our best Delta deals on Myrtle Beach to San Diego flight tickets
Delta
Dec 2
MYR11:29 amMyrtle Beach Intl
9h 51m
1 stop
SAN6:20 pmSan Diego
Dec 15
SAN10:00 pmSan Diego
9h 34m
1 stop
MYR10:34 amMyrtle Beach Intl
$332
Find similar
Delta
Dec 2
MYR6:56 pmMyrtle Beach Intl
7h 50m
1 stop
SAN11:46 pmSan Diego
Dec 7
SAN10:00 pmSan Diego
9h 34m
1 stop
MYR10:34 amMyrtle Beach Intl
$358
Find similar
Delta
Oct 22
MYR6:58 pmMyrtle Beach Intl
7h 16m
1 stop
SAN11:14 pmSan Diego
Oct 25
SAN7:03 pmSan Diego
12h 31m
2 stops
MYR10:34 amMyrtle Beach Intl
$435
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momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 7, 2025.
Use the filters below to find and compare flights from Myrtle Beach to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 10/21

7:00 am-12:04 pm

1 stop8h 04m

San Diego

Tue 10/28

10:31 pm-9:37 am

1 stop8h 06m

$295

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 10/21

7:00 am-12:29 pm

1 stop8h 29m

San Diego

Tue 10/28

10:46 am-10:54 pm

2 stops9h 08m

$300

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 10/9

7:45 am-5:50 pm

1 stop13h 05m

San Diego

Mon 10/13

6:35 am-5:15 pm

1 stop7h 40m

$318

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 12/2

11:29 am-6:20 pm

1 stop9h 51m

San Diego

Mon 12/15

10:00 pm-10:34 am

1 stop9h 34m

$332

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 12/2

6:56 pm-11:46 pm

1 stop7h 50m

San Diego

Sun 12/7

10:00 pm-10:34 am

1 stop9h 34m

$358

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 10/9

7:45 am-5:50 pm

1 stop13h 05m

San Diego

Sun 10/12

6:35 am-11:30 pm

1 stop13h 55m

$391

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 10/21

4:33 pm-9:12 am

2 stops19h 39m

San Diego

Tue 10/28

10:30 pm-1:09 pm

2 stops11h 39m

$460

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 10/21

5:37 pm-9:12 am

2 stops18h 35m

San Diego

Tue 10/28

7:50 pm-1:09 pm

2 stops14h 19m

$465

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 9/18

11:36 am-11:03 am

1 stop26h 27m

San Diego

Sun 9/21

6:35 am-8:44 am

2 stops23h 09m

$483

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sun 9/14

11:36 am-11:03 am

1 stop26h 27m

San Diego

Tue 9/16

6:15 am-8:44 am

2 stops23h 29m

$529

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Myrtle Beach to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of September, then departing from Myrtle Beach during the month May is also very affordable. Most momondo users find prices during this month for around $384.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Myrtle Beach to San Diego is on a Tuesday. Travelers who choose to depart for San Diego on a Tuesday will often find tickets for as low as $428. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $597. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $454. Flights in the afternoon are often more expensive with an average ticket price of $520.

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Myrtle Beach when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $441 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Myrtle Beach for as low as $365 on momondo.

How have Myrtle Beach to San Diego flight prices changed over time?

As of September 2025, prices for Myrtle Beach to San Diego flights are approximately 10% cheaper when compared to flights at the same time last year.

When to book flights from Myrtle Beach to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to San Diego (MYR to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to San Diego

Direct flights

None
There are no direct flights from Myrtle Beach to San Diego. There are no popular flight routes from Myrtle Beach to San Diego.
Search flight deals

  • How far is Myrtle Beach Intl to San Diego by plane?

    The distance between Myrtle Beach Intl and San Diego is about 2199.3 mi. A reasonable flight in good conditions will take 7h 12m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to San Diego Airport?

    Prices for flights from Myrtle Beach Intl Airport to San Diego Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to San Diego Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to San Diego Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to San Diego?

Best airlines flying from Myrtle Beach to San Diego

Compare and see reviews for airlines that fly from Myrtle Beach to San Diego with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $312Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $331Free CancellationRating
7.9
7,972 reviews
Search Delta flights
SouthwestPriceFrom $437Free CancellationRating
8.0
4,247 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
La Mesa
National City
Imperial Beach
Poway
San Ysidro
Borrego Springs
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Myrtle Beach to San Diego for you.

Can I find flights from Myrtle Beach to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to San Diego?

Once all potential Myrtle Beach to San Diego flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to San Diego right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to San Diego now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to San Diego and let you know when they change.

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