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Cheap flights from Missouri to San Diego from $58

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to San Diego departing on 12/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:43 pm - 1:33 pmSTL-SAN
19h 50m2 stops
Frontier Logo
4:47 pm - 10:14 amSAN-STL
15h 27m1 stop
$192Frontier
Find Deal
Wed, Dec 3 - Fri, Dec 5
Frontier Logo
1:16 pm - 12:38 pmSTL-SAN
25h 22m1 stop
Frontier Logo
3:05 pm - 10:14 amSAN-STL
41h 09m2 stops
$193Frontier
Find Deal
Thu, Dec 4 - Mon, Dec 8
Multiple Airlines Logo
2:50 pm - 8:58 pmSTL-SAN
8h 08m1 stop
Multiple Airlines Logo
8:00 am - 7:41 pmSAN-STL
9h 41m1 stop
$204Multiple Airlines
Find Deal
Tue, Jan 27 - Fri, Jan 30
Multiple Airlines Logo
7:00 am - 12:38 pmMCI-SAN
7h 38m1 stop
Multiple Airlines Logo
10:57 am - 10:58 amSAN-MCI
22h 01m1 stop
$240Multiple Airlines
Find Deal
Mon, Dec 22 - Wed, Dec 31
Delta Logo
5:00 pm - 10:48 pmSTL-SAN
7h 48m1 stop
Delta Logo
3:00 pm - 11:25 pmSAN-STL
6h 25m1 stop
$241Delta
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Tue, Mar 3 - Wed, Mar 4
United Airlines Logo
8:45 am - 12:59 pmCOU-SAN
6h 14m1 stop
United Airlines Logo
7:45 am - 9:37 pmSAN-COU
11h 52m2 stops
$264United Airlines
Find Deal
Sat, Jan 17 - Tue, Jan 20
Delta Logo
3:55 pm - 7:17 pmMCI-SAN
5h 22m1 stop
Delta Logo
1:41 pm - 11:22 pmSAN-MCI
7h 41m1 stop
$269Delta
Find Deal
Wed, Dec 3 - Fri, Dec 5
United Airlines Logo
3:10 pm - 12:15 amCOU-SAN
11h 05m2 stops
United Airlines Logo
9:55 am - 9:37 pmSAN-COU
9h 42m2 stops
$269United Airlines
Find Deal
Sat, Jan 17 - Tue, Jan 20
American Airlines Logo
12:10 pm - 3:57 pmSGF-SAN
5h 47m1 stop
American Airlines Logo
6:15 am - 4:17 pmSAN-SGF
8h 02m1 stop
$269American Airlines
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Tue, Feb 17 - Sat, Feb 21
American Airlines Logo
2:16 pm - 6:37 pmMCI-SAN
6h 21m1 stop
American Airlines Logo
6:15 am - 1:36 pmSAN-MCI
5h 21m1 stop
$293American Airlines
Find Deal
Sat, Dec 20 - Sat, Dec 27

Frontier flights from Missouri to San Diego

Our best Frontier deals on Missouri to San Diego flight tickets
Frontier
Dec 3
STL7:43 pmLambert-St Louis
19h 50m
2 stops
SAN1:33 pmSan Diego
Dec 5
SAN4:47 pmSan Diego
15h 27m
1 stop
STL10:14 amLambert-St Louis
$192
Find similar
Frontier
Dec 4
STL1:16 pmLambert-St Louis
25h 22m
1 stop
SAN12:38 pmSan Diego
Dec 8
SAN3:05 pmSan Diego
41h 09m
2 stops
STL10:14 amLambert-St Louis
$193
Find similar
Frontier
Nov 23
STL7:57 pmLambert-St Louis
13h 47m
2 stops
SAN7:44 amSan Diego
Dec 2
SAN6:25 amSan Diego
25h 49m
1 stop
STL10:14 amLambert-St Louis
$194
Find similar

Delta flights from Missouri to San Diego

Our best Delta deals on Missouri to San Diego flight tickets
Delta
Mar 3
STL5:00 pmLambert-St Louis
7h 48m
1 stop
SAN10:48 pmSan Diego
Mar 4
SAN3:00 pmSan Diego
6h 25m
1 stop
STL11:25 pmLambert-St Louis
$241
Find similar
Delta
Dec 3
MCI3:55 pmKansas City
5h 22m
1 stop
SAN7:17 pmSan Diego
Dec 5
SAN1:41 pmSan Diego
7h 41m
1 stop
MCI11:22 pmKansas City
$269
Find similar
Delta
Feb 12
MCI7:00 amKansas City
9h 19m
1 stop
SAN2:19 pmSan Diego
Feb 17
SAN11:00 amSan Diego
10h 42m
1 stop
MCI11:42 pmKansas City
$294
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 10, 2025.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 12/3

7:43 pm-1:33 pm

2 stops19h 50m

San Diego

Fri 12/5

4:47 pm-10:14 am

1 stop15h 27m

$192

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Thu 12/4

1:16 pm-12:38 pm

1 stop25h 22m

San Diego

Mon 12/8

3:05 pm-10:14 am

2 stops41h 09m

$193

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 1/27

2:50 pm-8:58 pm

1 stop8h 08m

San Diego

Fri 1/30

8:00 am-7:41 pm

1 stop9h 41m

$204

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 12/22

7:00 am-12:38 pm

1 stop7h 38m

San Diego

Wed 12/31

10:57 am-10:58 am

1 stop22h 01m

$240

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 3/3

5:00 pm-10:48 pm

1 stop7h 48m

San Diego

Wed 3/4

3:00 pm-11:25 pm

1 stop6h 25m

$241

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 1/17

8:45 am-12:59 pm

1 stop6h 14m

San Diego

Tue 1/20

7:45 am-9:37 pm

2 stops11h 52m

$264

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Wed 12/3

3:55 pm-7:17 pm

1 stop5h 22m

San Diego

Fri 12/5

1:41 pm-11:22 pm

1 stop7h 41m

$269

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 1/17

3:10 pm-12:15 am

2 stops11h 05m

San Diego

Tue 1/20

9:55 am-9:37 pm

2 stops9h 42m

$269

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Tue 2/17

12:10 pm-3:57 pm

1 stop5h 47m

San Diego

Sat 2/21

6:15 am-4:17 pm

1 stop8h 02m

$269

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Sat 12/20

2:16 pm-6:37 pm

1 stop6h 21m

San Diego

Sat 12/27

6:15 am-1:36 pm

1 stop5h 21m

$293

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Missouri to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Missouri during the month January is also very affordable. Most momondo users find prices during this month for around $319.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Missouri to San Diego is on a Tuesday. Travelers who choose to depart for San Diego on a Tuesday will often find tickets for as low as $436. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $616. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $455. Flights at noon are often more expensive with an average ticket price of $601.

What is the cheapest Missouri to San Diego flight route?

Fly from Kansas City to San Diego for the best Missouri - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $364 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Missouri for as low as $321 on momondo.

What cabin class options are available on Missouri to San Diego flights?

There is only 1 cabin class available to choose from on Missouri to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Missouri to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to San Diego

Best Price Found

$166

Fastest flight time

3h 30m

Direct flights

Every day

Airports in San Diego

1 airport
The best one-way flight to San Diego from Missouri in the past 72 hours is $166. The best round-trip flight deal from Missouri to San Diego found on momondo in the last 72 hours is $362.
The fastest flight from Missouri to San Diego takes 3h 30m
Direct flights go from Missouri to San Diego every day.
There is 1 airport near San Diego: San Diego (SAN)
Search flight deals

  • When did momondo last update prices for flights from Missouri to San Diego Airport?

    Prices for flights from Missouri to San Diego Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to San Diego Airport?

  • How old do you have to be to fly from Missouri to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents required for your trip to San Diego Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Diego Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Missouri to San Diego?

Best airlines flying from Missouri to San Diego

Compare and see reviews for airlines that fly from Missouri to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $82Free CancellationRating
6.3
8,132 reviews
Search Spirit Airlines flights
FrontierPriceFrom $88Free CancellationRating
5.8
3,111 reviews
Search Frontier flights
United AirlinesPriceFrom $182Free CancellationRating
7.4
9,011 reviews
Search United Airlines flights
American AirlinesPriceFrom $226Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights
Alaska AirlinesPriceFrom $228Free CancellationRating
8.0
11,259 reviews
Search Alaska Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,004 reviews
Search Delta flights
SouthwestPriceFrom $266Free CancellationRating
8.0
4,236 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Imperial Beach
La Mesa
Poway
Borrego Springs
San Ysidro
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Missouri with this policy.

How can momondo help me find flights from Missouri to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Missouri.

I’m not ready to book a flight from Missouri to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Missouri. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your San Diego trip

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Wed 12/10
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