Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from Missouri to San Diego from $76

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to San Diego departing on 9/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Missouri to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:08 pm - 11:51 pm
STL
-
SAN
5h 43m
1 stop
Frontier Logo
6:35 am - 2:56 pm
SAN
-
STL
6h 21m
1 stop
$265Frontier
Thu, Jul 9 - Thu, Jul 16
Frontier Logo
7:38 pm - 8:42 am
STL
-
SAN
15h 04m
1 stop
Frontier Logo
5:57 pm - 7:23 pm
SAN
-
STL
23h 26m
1 stop
$268Frontier
Fri, Jul 3 - Mon, Jul 6
Delta Logo
4:04 pm - 8:35 pm
MCI
-
SAN
6h 31m
1 stop
Delta Logo
3:00 pm - 11:41 pm
SAN
-
MCI
6h 41m
1 stop
$277Delta
Wed, Jul 15 - Fri, Jul 17
United Airlines Logo
6:00 am - 11:35 am
MCI
-
SAN
7h 35m
2 stops
United Airlines Logo
6:17 am - 2:33 pm
SAN
-
MCI
6h 16m
1 stop
$282United Airlines
Tue, Aug 11 - Fri, Aug 14
Delta Logo
6:01 pm - 11:50 pm
MCI
-
SAN
7h 49m
1 stop
Delta Logo
3:30 pm - 11:27 pm
SAN
-
MCI
5h 57m
1 stop
$287Delta
Thu, Aug 6 - Mon, Aug 10
Multiple Airlines Logo
8:55 pm - 3:27 pm
SGF
-
SAN
20h 32m
1 stop
Multiple Airlines Logo
8:51 pm - 11:06 am
SAN
-
SGF
36h 15m
2 stops
$305Multiple Airlines
Fri, Jul 17 - Mon, Jul 20
American Airlines Logo
6:32 pm - 11:25 pm
COU
-
SAN
6h 53m
1 stop
American Airlines Logo
10:46 pm - 9:56 am
SAN
-
COU
9h 10m
1 stop
$318American Airlines
Thu, Sep 17 - Mon, Sep 21
American Airlines Logo
6:22 pm - 11:26 pm
COU
-
SAN
7h 04m
1 stop
American Airlines Logo
7:15 am - 4:49 pm
SAN
-
COU
7h 34m
1 stop
$319American Airlines
Sat, Jul 18 - Sat, Jul 25
United Airlines Logo
10:55 am - 7:55 pm
COU
-
SAN
11h 00m
2 stops
United Airlines Logo
12:33 pm - 8:59 pm
SAN
-
COU
6h 26m
1 stop
$324United Airlines
Wed, Aug 12 - Wed, Aug 19
Multiple Airlines Logo
9:17 pm - 8:42 am
SGF
-
SAN
13h 25m
2 stops
Multiple Airlines Logo
9:53 pm - 8:45 pm
SAN
-
SGF
20h 52m
1 stop
$349Multiple Airlines
Mon, Aug 31 - Thu, Sep 3

Southwest flights from Missouri to San Diego

Our best Southwest deals on Missouri to San Diego flight tickets
Southwest
Jun 19
MCI7:10 pmKansas City
6h 05m
1 stop
SAN11:15 pmSan Diego
Jun 22
SAN6:05 pmSan Diego
5h 35m
1 stop
MCI1:40 amKansas City
$277
Southwest
Jul 4
STL7:10 amLambert-St Louis
8h 20m
2 stops
SAN1:30 pmSan Diego
Jul 6
SAN10:40 pmSan Diego
7h 05m
1 stop
STL7:45 amLambert-St Louis
$302
Southwest
Jun 20
MCI6:50 pmKansas City
5h 30m
1 stop
SAN10:20 pmSan Diego
Jun 26
SAN4:25 pmSan Diego
5h 30m
1 stop
MCI11:55 pmKansas City
$303

Frontier flights from Missouri to San Diego

Our best Frontier deals on Missouri to San Diego flight tickets
Frontier
Jul 9
STL8:08 pmLambert-St Louis
5h 43m
1 stop
SAN11:51 pmSan Diego
Jul 16
SAN6:35 amSan Diego
6h 21m
1 stop
STL2:56 pmLambert-St Louis
$265
Frontier
Jul 3
STL7:38 pmLambert-St Louis
15h 04m
1 stop
SAN8:42 amSan Diego
Jul 6
SAN5:57 pmSan Diego
23h 26m
1 stop
STL7:23 pmLambert-St Louis
$268
Frontier
Jul 7
STL7:03 pmLambert-St Louis
21h 05m
1 stop
SAN2:08 pmSan Diego
Jul 14
SAN4:12 pmSan Diego
23h 53m
2 stops
STL6:05 pmLambert-St Louis
$270

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 7, 2026.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Thu 7/9

8:08 pm-11:51 pm

1 stop5h 43m

San Diego

Thu 7/16

6:35 am-2:56 pm

1 stop6h 21m

$265

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 7/3

7:38 pm-8:42 am

1 stop15h 04m

San Diego

Mon 7/6

5:57 pm-7:23 pm

1 stop23h 26m

$268

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Wed 7/15

4:04 pm-8:35 pm

1 stop6h 31m

San Diego

Fri 7/17

3:00 pm-11:41 pm

1 stop6h 41m

$277

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 8/11

6:00 am-11:35 am

2 stops7h 35m

San Diego

Fri 8/14

6:17 am-2:33 pm

1 stop6h 16m

$282

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 8/6

6:01 pm-11:50 pm

1 stop7h 49m

San Diego

Mon 8/10

3:30 pm-11:27 pm

1 stop5h 57m

$287

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Fri 7/17

8:55 pm-3:27 pm

1 stop20h 32m

San Diego

Mon 7/20

8:51 pm-11:06 am

2 stops36h 15m

$305

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Thu 9/17

6:32 pm-11:25 pm

1 stop6h 53m

San Diego

Mon 9/21

10:46 pm-9:56 am

1 stop9h 10m

$318

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 7/18

6:22 pm-11:26 pm

1 stop7h 04m

San Diego

Sat 7/25

7:15 am-4:49 pm

1 stop7h 34m

$319

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Wed 8/12

10:55 am-7:55 pm

2 stops11h 00m

San Diego

Wed 8/19

12:33 pm-8:59 pm

1 stop6h 26m

$324

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Mon 8/31

9:17 pm-8:42 am

2 stops13h 25m

San Diego

Thu 9/3

9:53 pm-8:45 pm

1 stop20h 52m

$349

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Diego from

How to get the cheapest flight ticket from Missouri to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of September, then departing from Missouri during the month December is also very affordable. Most momondo users find prices during this month for around $69.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Missouri to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $419. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $577. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $407. Flights at noon are often more expensive with an average ticket price of $544.

What is the cheapest Missouri to San Diego flight route?

Fly from Kansas City to San Diego for the best Missouri - San Diego flight prices

How far in advance should I book a flight from Missouri to San Diego?

You are more likely to see cheaper flights to San Diego from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $399 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Missouri for as low as $339 on momondo.

What cabin class options are available on Missouri to San Diego flights?

There is only 1 cabin class available to choose from on Missouri to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Missouri to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to San Diego

Best Price Found

$268

Fastest flight time

3h 15m

Direct flights

Every day

Airports in San Diego

1 airport
The best one-way flight to San Diego from Missouri in the past 72 hours is $268. The best round-trip flight deal from Missouri to San Diego found on momondo in the last 72 hours is $488.
The fastest flight from Missouri to San Diego takes 3h 15m
Direct flights go from Missouri to San Diego every day.
There is 1 airport in San Diego. From Missouri there are direct flights to San Diego (SAN).
Search flight deals

Frequently asked questions about flying from Missouri to San Diego

  • When did momondo last update prices for flights from Missouri to San Diego Airport?

    Prices for flights from Missouri to San Diego Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to San Diego Airport?

  • How old do you have to be to fly from Missouri to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents required for your trip to San Diego Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Diego Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Missouri to San Diego?

Best airlines flying from Missouri to San Diego

Compare and see reviews for airlines that fly from Missouri to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $88Free CancellationRating
5.6
2,907 reviews
Search Frontier flights
United AirlinesPriceFrom $182Free CancellationRating
7.4
9,777 reviews
Search United Airlines flights
American AirlinesPriceFrom $210Free CancellationRating
7.1
11,649 reviews
Search American Airlines flights
DeltaPriceFrom $216Free CancellationRating
7.9
8,396 reviews
Search Delta flights
SouthwestPriceFrom $258Free CancellationRating
8.0
4,257 reviews
Search Southwest flights
Alaska AirlinesPriceFrom $418Free CancellationRating
7.9
12,474 reviews
Search Alaska Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
Coronado
El Cajon
Julian
National City
Poway
San Ysidro
La Mesa
Borrego Springs
Lemon Grove
Imperial Beach
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Missouri with this policy.

How can momondo help me find flights from Missouri to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Missouri.

I’m not ready to book a flight from Missouri to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Missouri. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your San Diego trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Tue 7/7
Tue 7/14
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States