Cheap flights from Missouri to San Diego from $38

If you are unable to visit San Diego during the month of April, then departing from Missouri during the month February is also very affordable. Most momondo users find prices during this month for around $358.

The cheapest day to depart from Missouri to San Diego is on a Thursday. Travelers who choose to depart for San Diego on a Thursday will often find tickets for as low as $462. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $590. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $453. Flights at noon are often more expensive with an average ticket price of $626.

Fly from Lambert-St Louis to San Diego for the best Missouri - San Diego flight prices

You are more likely to see cheaper flights to San Diego from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $402 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Missouri for as low as $329 on momondo.

There is only 1 cabin class available to choose from on Missouri to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest, Frontier, and Delta are the most popular carriers operating from Missouri to San Diego

Southwest, American Airlines and United Airlines are the top three most popular airlines that fly to San Diego from Missouri according to our data. Southwest is the first choice among our users, with 41% of people opting to fly with this airline when traveling to San Diego. Keep in mind that there are 7 different airlines that fly to San Diego on a routine basis, so you have a few additional options to choose from.

1 flights are operational daily from Missouri to San Diego as of October 2026. The most popular departure time for this route is 6:00AM, with 63% of flights per day taking off at noon.

9 flights are operational weekly from Missouri to San Diego as of October 2026. The most popular departure day for this route is Sat, with 33% of flights per week taking off on this day.