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Cheap flights from Missouri to San Diego from $65

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to San Diego departing on 5/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Missouri to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
2:15 pm - 10:59 pm
MCI
-
SAN
10h 44m
1 stop
Delta Logo
10:10 pm - 9:51 am
SAN
-
MCI
9h 41m
1 stop
$217Delta
Wed, Mar 18 - Mon, Mar 23
Frontier Logo
8:28 pm - 8:26 pm
MCI
-
SAN
25h 58m
1 stop
Frontier Logo
9:28 pm - 7:58 pm
SAN
-
MCI
20h 30m
1 stop
$220Frontier
Sun, Apr 5 - Fri, Apr 10
United Airlines Logo
4:06 pm - 8:12 pm
MCI
-
SAN
6h 06m
1 stop
United Airlines Logo
11:01 am - 8:34 pm
SAN
-
MCI
7h 33m
2 stops
$222United Airlines
Thu, Apr 9 - Tue, Apr 14
Frontier Logo
8:43 pm - 2:04 pm
MCI
-
SAN
19h 21m
2 stops
Frontier Logo
9:28 pm - 7:58 pm
SAN
-
MCI
20h 30m
1 stop
$226Frontier
Mon, Apr 6 - Fri, Apr 10
Frontier Logo
8:46 pm - 7:21 am
MCI
-
SAN
12h 35m
2 stops
Frontier Logo
9:28 pm - 7:58 pm
SAN
-
MCI
20h 30m
1 stop
$227Frontier
Thu, Apr 9 - Sun, Apr 12
Multiple Airlines Logo
6:04 pm - 3:36 pm
MCI
-
SAN
23h 32m
2 stops
Multiple Airlines Logo
9:28 pm - 7:58 pm
SAN
-
MCI
20h 30m
1 stop
$234Multiple Airlines
Tue, Mar 31 - Fri, Apr 3
Multiple Airlines Logo
8:43 pm - 2:04 pm
MCI
-
SAN
19h 21m
2 stops
Multiple Airlines Logo
2:12 pm - 11:36 pm
SAN
-
MCI
7h 24m
1 stop
$235Multiple Airlines
Tue, Apr 7 - Wed, Apr 15
American Airlines Logo
5:21 pm - 11:33 pm
STL
-
SAN
8h 12m
1 stop
American Airlines Logo
10:40 pm - 11:47 am
SAN
-
STL
11h 07m
1 stop
$249American Airlines
Wed, May 6 - Mon, May 11
American Airlines Logo
6:00 am - 2:23 pm
COU
-
SAN
10h 23m
1 stop
American Airlines Logo
6:20 am - 8:26 pm
SAN
-
COU
12h 06m
1 stop
$304American Airlines
Tue, Mar 24 - Tue, Mar 31
United Airlines Logo
1:57 pm - 5:20 pm
JLN
-
SAN
5h 23m
1 stop
United Airlines Logo
10:49 am - 11:44 pm
SAN
-
JLN
10h 55m
2 stops
$319United Airlines
Wed, Jul 15 - Wed, Jul 22

Delta flights from Missouri to San Diego

Our best Delta deals on Missouri to San Diego flight tickets
Delta
Mar 18
MCI2:15 pmKansas City
10h 44m
1 stop
SAN10:59 pmSan Diego
Mar 23
SAN10:10 pmSan Diego
9h 41m
1 stop
MCI9:51 amKansas City
$217
Delta
Apr 3
MCI2:16 pmKansas City
10h 43m
1 stop
SAN10:59 pmSan Diego
Apr 15
SAN7:30 amSan Diego
15h 08m
2 stops
MCI12:38 amKansas City
$237
Delta
Mar 24
MCI2:15 pmKansas City
10h 44m
1 stop
SAN10:59 pmSan Diego
Mar 31
SAN7:30 amSan Diego
9h 51m
2 stops
MCI7:21 pmKansas City
$239

American Airlines flights from Missouri to San Diego

Our best American Airlines deals on Missouri to San Diego flight tickets
American Airlines
May 6
STL5:21 pmLambert-St Louis
8h 12m
1 stop
SAN11:33 pmSan Diego
May 11
SAN10:40 pmSan Diego
11h 07m
1 stop
STL11:47 amLambert-St Louis
$249
American Airlines
Mar 20
MCI7:47 pmKansas City
6h 12m
1 stop
SAN11:59 pmSan Diego
Mar 24
SAN10:35 pmSan Diego
8h 18m
1 stop
MCI8:53 amKansas City
$278
American Airlines
Mar 6
MCI7:46 pmKansas City
6h 13m
1 stop
SAN11:59 pmSan Diego
Mar 11
SAN2:18 pmSan Diego
7h 54m
1 stop
MCI12:12 amKansas City
$288

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 27, 2026.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Wed 3/18

2:15 pm-10:59 pm

1 stop10h 44m

San Diego

Mon 3/23

10:10 pm-9:51 am

1 stop9h 41m

$217

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Sun 4/5

8:28 pm-8:26 pm

1 stop25h 58m

San Diego

Fri 4/10

9:28 pm-7:58 pm

1 stop20h 30m

$220

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 4/9

4:06 pm-8:12 pm

1 stop6h 06m

San Diego

Tue 4/14

11:01 am-8:34 pm

2 stops7h 33m

$222

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 4/6

8:43 pm-2:04 pm

2 stops19h 21m

San Diego

Fri 4/10

9:28 pm-7:58 pm

1 stop20h 30m

$226

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 4/9

8:46 pm-7:21 am

2 stops12h 35m

San Diego

Sun 4/12

9:28 pm-7:58 pm

1 stop20h 30m

$227

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 3/31

6:04 pm-3:36 pm

2 stops23h 32m

San Diego

Fri 4/3

9:28 pm-7:58 pm

1 stop20h 30m

$234

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 4/7

8:43 pm-2:04 pm

2 stops19h 21m

San Diego

Wed 4/15

2:12 pm-11:36 pm

1 stop7h 24m

$235

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 5/6

5:21 pm-11:33 pm

1 stop8h 12m

San Diego

Mon 5/11

10:40 pm-11:47 am

1 stop11h 07m

$249

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 3/24

6:00 am-2:23 pm

1 stop10h 23m

San Diego

Tue 3/31

6:20 am-8:26 pm

1 stop12h 06m

$304

JoplinSan Diego

JLN - SAN

JLNSAN

Joplin

Wed 7/15

1:57 pm-5:20 pm

1 stop5h 23m

San Diego

Wed 7/22

10:49 am-11:44 pm

2 stops10h 55m

$319

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Missouri to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Missouri during the month July is also very affordable. Most momondo users find prices during this month for around $343.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Missouri to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $419. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $584. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $456. Flights in the evening are often more expensive with an average ticket price of $586.

What is the cheapest Missouri to San Diego flight route?

Fly from Lambert-St Louis to San Diego for the best Missouri - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $387 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Missouri for as low as $336 on momondo.

What cabin class options are available on Missouri to San Diego flights?

There is only 1 cabin class available to choose from on Missouri to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Missouri to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to San Diego

Best Price Found

$214

Fastest flight time

3h 15m

Direct flights

Every day

Airports in San Diego

1 airport
The best one-way flight to San Diego from Missouri in the past 72 hours is $214. The best round-trip flight deal from Missouri to San Diego found on momondo in the last 72 hours is $348.
The fastest flight from Missouri to San Diego takes 3h 15m
Direct flights go from Missouri to San Diego every day.
There is 1 airport in San Diego. From Missouri there are direct flights to San Diego (SAN).
Search flight deals

  • When did momondo last update prices for flights from Missouri to San Diego Airport?

    Prices for flights from Missouri to San Diego Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to San Diego Airport?

  • How old do you have to be to fly from Missouri to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents required for your trip to San Diego Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Diego Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Missouri to San Diego?

Best airlines flying from Missouri to San Diego

Compare and see reviews for airlines that fly from Missouri to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $88Free CancellationRating
5.7
3,041 reviews
Search Frontier flights
Spirit AirlinesPriceFrom $100Free CancellationRating
6.3
8,492 reviews
Search Spirit Airlines flights
Alaska AirlinesPriceFrom $124Free CancellationRating
8.0
11,965 reviews
Search Alaska Airlines flights
DeltaPriceFrom $138Free CancellationRating
7.9
8,241 reviews
Search Delta flights
United AirlinesPriceFrom $182Free CancellationRating
7.4
9,352 reviews
Search United Airlines flights
American AirlinesPriceFrom $218Free CancellationRating
7.2
11,360 reviews
Search American Airlines flights
SouthwestPriceFrom $268Free CancellationRating
8.0
4,301 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
Poway
National City
Imperial Beach
San Ysidro
Borrego Springs
La Mesa
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Missouri with this policy.

How can momondo help me find flights from Missouri to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Missouri.

I’m not ready to book a flight from Missouri to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Missouri. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your San Diego trip

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