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Cheap flights from Missouri to San Diego from $75

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to San Diego departing on 10/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Missouri to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:32 pm - 3:58 pmMCI  Kansas City-SAN San Diego
21h 26m1 stop Denver Intl
Frontier Logo
4:54 pm - 7:37 pmSAN  San Diego-MCI Kansas City
24h 43m1 stop Denver Intl
$162Frontier
Fri, Sep 11 - Mon, Sep 14
Frontier Logo
8:32 pm - 3:58 pmMCI  Kansas City-SAN San Diego
21h 26m1 stop Denver Intl
Frontier Logo
7:04 pm - 7:37 pmSAN  San Diego-MCI Kansas City
22h 33m2 stops Phoenix Sky Harbor Intl Denver Intl
$164Frontier
Fri, Sep 11 - Mon, Sep 14
Southwest Logo
8:45 am - 10:40 amSTL  Lambert-St Louis-SAN San Diego
3h 55mnonstop
Southwest Logo
6:25 am - 3:45 pmSAN  San Diego-STL Lambert-St Louis
7h 20m1 stop Nashville Intl
$262Southwest
Sat, Oct 24 - Sat, Oct 31
Southwest Logo
2:05 pm - 7:15 pmSTL  Lambert-St Louis-SAN San Diego
7h 10m1 stop Phoenix Sky Harbor Intl
Southwest Logo
1:20 pm - 7:00 pmSAN  San Diego-STL Lambert-St Louis
3h 40mnonstop
$262Southwest
Mon, Oct 26 - Thu, Oct 29
Delta Logo
7:45 pm - 11:50 pmSTL  Lambert-St Louis-SAN San Diego
6h 05m1 stop Salt Lake City
Delta Logo
3:20 pm - 11:16 pmSAN  San Diego-STL Lambert-St Louis
5h 56m1 stop Minneapolis St Paul
$268Delta
Fri, Sep 4 - Tue, Sep 8
Multiple Airlines Logo
12:17 pm - 4:59 pmSTL  Lambert-St Louis-SAN San Diego
6h 42m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
6:55 am - 5:10 pmSAN  San Diego-STL Lambert-St Louis
8h 15m1 stop Portland
$268Multiple Airlines
Tue, Sep 22 - Sun, Sep 27
Delta Logo
7:00 pm - 11:55 pmSTL  Lambert-St Louis-SAN San Diego
6h 55m1 stop Salt Lake City
Delta Logo
3:30 pm - 11:21 pmSAN  San Diego-STL Lambert-St Louis
5h 51m1 stop Minneapolis St Paul
$272Delta
Thu, Oct 8 - Tue, Oct 13
United Airlines Logo
1:08 pm - 6:34 pmSTL  Lambert-St Louis-SAN San Diego
7h 26m1 stop Chicago O'Hare Intl
United Airlines Logo
12:45 pm - 8:59 pmSAN  San Diego-STL Lambert-St Louis
6h 14m1 stop Denver Intl
$272United Airlines
Tue, Nov 24 - Tue, Dec 1
United Airlines Logo
6:00 am - 11:27 amSTL  Lambert-St Louis-SAN San Diego
7h 27m1 stop Chicago O'Hare Intl
United Airlines Logo
12:45 pm - 8:59 pmSAN  San Diego-STL Lambert-St Louis
6h 14m1 stop Denver Intl
$272United Airlines
Wed, Nov 25 - Wed, Dec 2
Multiple Airlines Logo
7:42 pm - 11:56 pmSTL  Lambert-St Louis-SAN San Diego
6h 14m1 stop Denver Intl
Multiple Airlines Logo
6:15 am - 11:59 pmSAN  San Diego-STL Lambert-St Louis
15h 44m1 stop Seattle/Tacoma Intl
$275Multiple Airlines
Sat, Oct 10 - Mon, Oct 12

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Frontier flights from Missouri to San Diego

Our best Frontier deals on Missouri to San Diego flight tickets
Frontier
Sep 11
MCI8:32 pmKansas City
21h 26m
1 stop
SAN3:58 pmSan Diego
Sep 14
SAN4:54 pmSan Diego
24h 43m
1 stop
MCI7:37 pmKansas City
$162
Frontier
Sep 11
MCI8:32 pmKansas City
21h 26m
1 stop
SAN3:58 pmSan Diego
Sep 14
SAN7:04 pmSan Diego
22h 33m
2 stops
MCI7:37 pmKansas City
$164
Frontier
Sep 11
MCI8:32 pmKansas City
21h 26m
1 stop
SAN3:58 pmSan Diego
Sep 14
SAN4:54 pmSan Diego
24h 43m
1 stop
MCI7:37 pmKansas City
$168

United Airlines flights from Missouri to San Diego

Our best United Airlines deals on Missouri to San Diego flight tickets
United Airlines
Sep 2
STL8:42 amLambert-St Louis
7h 02m
1 stop
SAN1:44 pmSan Diego
Sep 6
SAN2:24 pmSan Diego
7h 07m
2 stops
STL11:31 pmLambert-St Louis
$308
United Airlines
Oct 17
JLN7:32 amJoplin
10h 17m
1 stop
SAN3:49 pmSan Diego
Oct 21
SAN4:11 pmSan Diego
5h 33m
1 stop
JLN11:44 pmJoplin
$334
United Airlines
Oct 17
JLN7:32 amJoplin
13h 03m
2 stops
SAN6:35 pmSan Diego
Oct 21
SAN4:11 pmSan Diego
5h 33m
1 stop
JLN11:44 pmJoplin
$340

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Kansas CitySan Diego

MCI Kansas City - SAN San Diego

MCISAN

Kansas City

Fri 9/11

8:32 pm-3:58 pm

1 stop21h 26m

San Diego

Mon 9/14

4:54 pm-7:37 pm

1 stop24h 43m

$162

Kansas CitySan Diego

MCI Kansas City - SAN San Diego

MCISAN

Kansas City

Fri 9/11

8:32 pm-3:58 pm

1 stop21h 26m

San Diego

Mon 9/14

7:04 pm-7:37 pm

2 stops22h 33m

$164

St. LouisSan Diego

STL Lambert-St Louis - SAN San Diego

STLSAN

Lambert-St Louis

Sat 10/24

8:45 am-10:40 am

Nonstop3h 55m

San Diego

Sat 10/31

6:25 am-3:45 pm

1 stop7h 20m

$262
Quickest round-trip

St. LouisSan Diego

STL Lambert-St Louis - SAN San Diego

STLSAN

Lambert-St Louis

Mon 10/26

2:05 pm-7:15 pm

1 stop7h 10m

San Diego

Thu 10/29

1:20 pm-7:00 pm

Nonstop3h 40m

$262

St. LouisSan Diego

STL Lambert-St Louis - SAN San Diego

STLSAN

Lambert-St Louis

Fri 9/4

7:45 pm-11:50 pm

1 stop6h 05m

San Diego

Tue 9/8

3:20 pm-11:16 pm

1 stop5h 56m

$268

St. LouisSan Diego

STL Lambert-St Louis - SAN San Diego

STLSAN

Lambert-St Louis

Tue 9/22

12:17 pm-4:59 pm

1 stop6h 42m

San Diego

Sun 9/27

6:55 am-5:10 pm

1 stop8h 15m

$268

St. LouisSan Diego

STL Lambert-St Louis - SAN San Diego

STLSAN

Lambert-St Louis

Thu 10/8

7:00 pm-11:55 pm

1 stop6h 55m

San Diego

Tue 10/13

3:30 pm-11:21 pm

1 stop5h 51m

$272

St. LouisSan Diego

STL Lambert-St Louis - SAN San Diego

STLSAN

Lambert-St Louis

Tue 11/24

1:08 pm-6:34 pm

1 stop7h 26m

San Diego

Tue 12/1

12:45 pm-8:59 pm

1 stop6h 14m

$272

St. LouisSan Diego

STL Lambert-St Louis - SAN San Diego

STLSAN

Lambert-St Louis

Wed 11/25

6:00 am-11:27 am

1 stop7h 27m

San Diego

Wed 12/2

12:45 pm-8:59 pm

1 stop6h 14m

$272

St. LouisSan Diego

STL Lambert-St Louis - SAN San Diego

STLSAN

Lambert-St Louis

Sat 10/10

7:42 pm-11:56 pm

1 stop6h 14m

San Diego

Mon 10/12

6:15 am-11:59 pm

1 stop15h 44m

$275

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Missouri to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of September, then departing from Missouri during the month October is also very affordable. Most momondo users find prices during this month for around $353.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Missouri to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $442. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $559. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $422. Flights at noon are often more expensive with an average ticket price of $626.

What is the cheapest Missouri to San Diego flight route?

Fly from Kansas City to San Diego for the best Missouri - San Diego flight prices

How far in advance should I book a flight from Missouri to San Diego?

You are more likely to see cheaper flights to San Diego from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $400 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Missouri for as low as $334 on momondo.

What cabin class options are available on Missouri to San Diego flights?

There is only 1 cabin class available to choose from on Missouri to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Missouri to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to San Diego

Best Price Found

$233

Fastest flight time

3h 15m

Direct flights

Every day

Airports in San Diego

1 airport
The best one-way flight to San Diego from Missouri in the past 72 hours is $233. The best round-trip flight deal from Missouri to San Diego found on momondo in the last 72 hours is $385.
The fastest flight from Missouri to San Diego takes 3h 15m
Direct flights go from Missouri to San Diego every day.
There is 1 airport in San Diego. From Missouri there are direct flights to San Diego (SAN).
Search flight deals

Frequently asked questions about flying from Missouri to San Diego

  • When did momondo last update prices for flights from Missouri to San Diego Airport?

    Prices for flights from Missouri to San Diego Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to San Diego Airport?

  • How old do you have to be to fly from Missouri to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents required for your trip to San Diego Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Diego Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Missouri to San Diego?

Best airlines flying from Missouri to San Diego

Compare and see reviews for airlines that fly from Missouri to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $96Free CancellationRating
5.6
2,675 reviews
Search Frontier flights
United AirlinesPriceFrom $182Free CancellationRating
7.4
10,106 reviews
Search United Airlines flights
DeltaPriceFrom $216Free CancellationRating
7.8
8,503 reviews
Search Delta flights
American AirlinesPriceFrom $231Free CancellationRating
7.1
11,944 reviews
Search American Airlines flights
SouthwestPriceFrom $268Free CancellationRating
8.0
4,218 reviews
Search Southwest flights
Alaska AirlinesPriceFrom $418Free CancellationRating
7.9
12,810 reviews
Search Alaska Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
Coronado
El Cajon
National City
Julian
La Mesa
Poway
San Ysidro
Imperial Beach
Santee
Borrego Springs
Lemon Grove
Alpine

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Missouri with this policy.

How can momondo help me find flights from Missouri to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Missouri.

I’m not ready to book a flight from Missouri to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Missouri. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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