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Cheap flights from Missouri to San Diego from $73

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to San Diego departing on 9/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Frontier Logo
7:02 pm - 11:50 pmMCI-SAN
6h 48m1 stop
Frontier Logo
7:00 am - 5:55 pmSAN-MCI
8h 55m1 stop
$145Frontier
Find Deal
Wed, Oct 8 - Sat, Oct 11
Frontier Logo
7:55 pm - 11:53 pmSTL-SAN
5h 58m1 stop
Frontier Logo
9:03 pm - 9:06 amSAN-STL
10h 03m1 stop
$145Frontier
Find Deal
Thu, Sep 4 - Sun, Sep 7
Spirit Airlines Logo
8:08 pm - 11:24 pmMCI-SAN
5h 16m1 stop
Spirit Airlines Logo
8:19 am - 4:56 pmSAN-MCI
6h 37m1 stop
$160Spirit Airlines
Find Deal
Thu, Oct 23 - Sun, Oct 26
Spirit Airlines Logo
8:08 pm - 7:24 amMCI-SAN
13h 16m1 stop
Spirit Airlines Logo
6:15 am - 2:00 pmSAN-MCI
5h 45m1 stop
$177Spirit Airlines
Find Deal
Fri, Oct 10 - Tue, Oct 14
Logo
3:01 pm - 11:53 pmMCI-SAN
10h 52m1 stop
Logo
6:15 am - 2:00 pmSAN-MCI
5h 45m1 stop
$182
Find Deal
Fri, Sep 12 - Thu, Sep 18
Logo
2:55 pm - 6:42 pmMCI-SAN
5h 47m1 stop
Logo
6:35 am - 1:48 pmSAN-MCI
5h 13m1 stop
$185
Find Deal
Fri, Sep 12 - Mon, Sep 15
American Airlines Logo
7:56 pm - 11:58 pmMCI-SAN
6h 02m1 stop
American Airlines Logo
6:15 am - 3:11 pmSAN-MCI
6h 56m1 stop
$191American Airlines
Find Deal
Thu, Sep 11 - Tue, Sep 23
American Airlines Logo
6:26 pm - 10:36 pmMCI-SAN
6h 10m1 stop
American Airlines Logo
9:45 am - 5:08 pmSAN-MCI
5h 23m1 stop
$195American Airlines
Find Deal
Wed, Sep 10 - Wed, Sep 17
Alaska Airlines Logo
3:35 pm - 10:58 pmSTL-SAN
9h 23m1 stop
Alaska Airlines Logo
7:15 am - 5:34 pmSAN-STL
8h 19m1 stop
$206Alaska Airlines
Find Deal
Sat, Sep 27 - Tue, Sep 30
Alaska Airlines Logo
3:35 pm - 10:58 pmSTL-SAN
9h 23m1 stop
Alaska Airlines Logo
6:53 pm - 5:34 pmSAN-STL
20h 41m2 stops
$233Alaska Airlines
Find Deal
Sat, Sep 27 - Tue, Sep 30

Frontier flights from Missouri to San Diego

Our best Frontier deals on Missouri to San Diego flight tickets
Frontier
Oct 8
MCI7:02 pmKansas City
6h 48m
1 stop
SAN11:50 pmSan Diego
Oct 11
SAN7:00 amSan Diego
8h 55m
1 stop
MCI5:55 pmKansas City
$145
Find similar
Frontier
Sep 18
STL10:49 amLambert-St Louis
8h 53m
1 stop
SAN5:42 pmSan Diego
Sep 21
SAN9:03 pmSan Diego
10h 03m
1 stop
STL9:06 amLambert-St Louis
$160
Find similar
Frontier
Sep 4
MCI3:01 pmKansas City
7h 06m
1 stop
SAN8:07 pmSan Diego
Sep 7
SAN6:35 amSan Diego
5h 13m
1 stop
MCI1:48 pmKansas City
$161
Find similar

Spirit Airlines flights from Missouri to San Diego

Our best Spirit Airlines deals on Missouri to San Diego flight tickets
Spirit Airlines
Oct 23
MCI8:08 pmKansas City
5h 16m
1 stop
SAN11:24 pmSan Diego
Oct 26
SAN8:19 amSan Diego
6h 37m
1 stop
MCI4:56 pmKansas City
$160
Find similar
Spirit Airlines
Oct 10
MCI8:08 pmKansas City
13h 16m
1 stop
SAN7:24 amSan Diego
Oct 14
SAN6:15 amSan Diego
5h 45m
1 stop
MCI2:00 pmKansas City
$177
Find similar
Spirit Airlines
Oct 24
MCI6:01 pmKansas City
7h 07m
1 stop
SAN11:08 pmSan Diego
Oct 29
SAN6:15 amSan Diego
5h 45m
1 stop
MCI2:00 pmKansas City
$181
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Wed 10/8

7:02 pm-11:50 pm

1 stop6h 48m

San Diego

Sat 10/11

7:00 am-5:55 pm

1 stop8h 55m

$145

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Thu 9/4

7:55 pm-11:53 pm

1 stop5h 58m

San Diego

Sun 9/7

9:03 pm-9:06 am

1 stop10h 03m

$145

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 10/23

8:08 pm-11:24 pm

1 stop5h 16m

San Diego

Sun 10/26

8:19 am-4:56 pm

1 stop6h 37m

$160

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 10/10

8:08 pm-7:24 am

1 stop13h 16m

San Diego

Tue 10/14

6:15 am-2:00 pm

1 stop5h 45m

$177

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 9/12

3:01 pm-11:53 pm

1 stop10h 52m

San Diego

Thu 9/18

6:15 am-2:00 pm

1 stop5h 45m

$182

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 9/12

2:55 pm-6:42 pm

1 stop5h 47m

San Diego

Mon 9/15

6:35 am-1:48 pm

1 stop5h 13m

$185

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 9/11

7:56 pm-11:58 pm

1 stop6h 02m

San Diego

Tue 9/23

6:15 am-3:11 pm

1 stop6h 56m

$191

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Wed 9/10

6:26 pm-10:36 pm

1 stop6h 10m

San Diego

Wed 9/17

9:45 am-5:08 pm

1 stop5h 23m

$195

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Sat 9/27

3:35 pm-10:58 pm

1 stop9h 23m

San Diego

Tue 9/30

7:15 am-5:34 pm

1 stop8h 19m

$206

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Sat 9/27

3:35 pm-10:58 pm

1 stop9h 23m

San Diego

Tue 9/30

6:53 pm-5:34 pm

2 stops20h 41m

$233

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Missouri to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of January, then departing from Missouri during the month February is also very affordable. Most momondo users find prices during this month for around $333.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Missouri to San Diego is on a Tuesday. Travelers who choose to depart for San Diego on a Tuesday will often find tickets for as low as $479. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $616. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $509. Flights at noon are often more expensive with an average ticket price of $571.

What is the cheapest Missouri to San Diego flight route?

Fly from Lambert-St Louis to San Diego for the best Missouri - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $359 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Missouri for as low as $312 on momondo.

What cabin class options are available on Missouri to San Diego flights?

There are 1 cabin classes available to choose from on Missouri to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Missouri to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to San Diego

Best Price Found

$73

Fastest flight time

3h 20m

Direct flights

Every day

Airports in San Diego

1 airport
The best one-way flight to San Diego from Missouri in the past 72 hours is $73. The best round-trip flight deal from Missouri to San Diego found on momondo in the last 72 hours is $145.
The fastest flight from Missouri to San Diego takes 3h 20m
Direct flights go from Missouri to San Diego every day.
There is 1 airport near San Diego: San Diego (SAN)
Search flight deals

  • When did momondo last update prices for flights from Missouri to San Diego Airport?

    Prices for flights from Missouri to San Diego Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to San Diego Airport?

  • How old do you have to be to fly from Missouri to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents required for your trip to San Diego Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Diego Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Missouri to San Diego?

Best airlines flying from Missouri to San Diego

Compare and see reviews for airlines that fly from Missouri to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $95Free CancellationRating
6.3
8,045 reviews
Search Spirit Airlines flights
FrontierPriceFrom $108Free CancellationRating
5.8
3,219 reviews
Search Frontier flights
Alaska AirlinesPriceFrom $228Free CancellationRating
8.0
10,000 reviews
Search Alaska Airlines flights
American AirlinesPriceFrom $232Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $236Free CancellationRating
8.0
7,980 reviews
Search Delta flights
United AirlinesPriceFrom $239Free CancellationRating
7.4
8,916 reviews
Search United Airlines flights
SouthwestPriceFrom $265Free CancellationRating
8.0
4,244 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
La Mesa
Imperial Beach
Poway
San Ysidro
Borrego Springs
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Missouri with this policy.

How can momondo help me find flights from Missouri to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Missouri.

I’m not ready to book a flight from Missouri to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Missouri. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your San Diego trip

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