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Cheap flights from Missouri to San Diego from $52

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to San Diego departing on 2/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Missouri to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
3:46 pm - 11:31 pm
STL
-
SAN
9h 45m1 stop
Frontier Logo
8:16 pm - 2:46 pm
SAN
-
STL
16h 30m1 stop
$109Frontier
Sat, Jan 31 - Fri, Feb 6
Frontier Logo
8:36 pm - 8:24 am
MCI
-
SAN
13h 48m1 stop
Frontier Logo
6:25 am - 7:48 pm
SAN
-
MCI
11h 23m1 stop
$110Frontier
Sat, Feb 21 - Mon, Feb 23
Frontier Logo
1:40 pm - 12:08 am
STL
-
SAN
12h 28m1 stop
Frontier Logo
8:16 pm - 2:46 pm
SAN
-
STL
16h 30m1 stop
$110Frontier
Mon, Feb 2 - Fri, Feb 6
Frontier Logo
1:40 pm - 12:08 am
STL
-
SAN
12h 28m1 stop
Frontier Logo
6:30 am - 6:44 pm
SAN
-
STL
10h 14m1 stop
$114Frontier
Mon, Jan 26 - Fri, Jan 30
United Airlines Logo
8:45 am - 3:04 pm
COU
-
SAN
8h 19m1 stop
United Airlines Logo
11:10 am - 8:33 pm
SAN
-
COU
7h 23m1 stop
$278United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
8:45 am - 12:59 pm
COU
-
SAN
6h 14m1 stop
United Airlines Logo
6:15 am - 8:33 pm
SAN
-
COU
12h 18m2 stops
$284United Airlines
Tue, Feb 3 - Sat, Feb 7
Multiple Airlines Logo
9:42 pm - 11:31 pm
SGF
-
SAN
27h 49m2 stops
Multiple Airlines Logo
2:56 pm - 8:52 pm
SAN
-
SGF
27h 56m1 stop
$286Multiple Airlines
Mon, Jan 26 - Thu, Feb 5
American Airlines Logo
7:34 am - 2:29 pm
SGF
-
SAN
8h 55m1 stop
American Airlines Logo
10:35 pm - 10:08 am
SAN
-
SGF
9h 33m1 stop
$289American Airlines
Wed, Feb 18 - Sat, Feb 21
Delta Logo
5:00 pm - 10:45 pm
SGF
-
SAN
7h 45m1 stop
Delta Logo
6:30 am - 4:15 pm
SAN
-
SGF
7h 45m1 stop
$314Delta
Sun, Jan 25 - Wed, Feb 4
Multiple Airlines Logo
9:42 pm - 10:25 am
SGF
-
SAN
38h 43m2 stops
Multiple Airlines Logo
2:56 pm - 8:52 pm
SAN
-
SGF
27h 56m1 stop
$317Multiple Airlines
Fri, Jan 23 - Thu, Feb 5

Frontier flights from Missouri to San Diego

Our best Frontier deals on Missouri to San Diego flight tickets
Frontier
Jan 31
STL3:46 pmLambert-St Louis
9h 45m
1 stop
SAN11:31 pmSan Diego
Feb 6
SAN8:16 pmSan Diego
16h 30m
1 stop
STL2:46 pmLambert-St Louis
$109
Frontier
Feb 21
MCI8:36 pmKansas City
13h 48m
1 stop
SAN8:24 amSan Diego
Feb 23
SAN6:25 amSan Diego
11h 23m
1 stop
MCI7:48 pmKansas City
$110
Frontier
Jan 26
STL1:40 pmLambert-St Louis
12h 28m
1 stop
SAN12:08 amSan Diego
Jan 30
SAN6:30 amSan Diego
10h 14m
1 stop
STL6:44 pmLambert-St Louis
$114

American Airlines flights from Missouri to San Diego

Our best American Airlines deals on Missouri to San Diego flight tickets
American Airlines
Feb 18
SGF7:34 amSpringfield-Branson
8h 55m
1 stop
SAN2:29 pmSan Diego
Feb 21
SAN10:35 pmSan Diego
9h 33m
1 stop
SGF10:08 amSpringfield-Branson
$289
American Airlines
Jan 16
MCI11:55 amKansas City
7h 14m
1 stop
SAN5:09 pmSan Diego
Jan 19
SAN4:00 pmSan Diego
5h 59m
1 stop
MCI11:59 pmKansas City
$338
American Airlines
Jan 28
SGF4:29 pmSpringfield-Branson
8h 21m
1 stop
SAN10:50 pmSan Diego
Feb 2
SAN3:12 pmSan Diego
5h 35m
1 stop
SGF10:47 pmSpringfield-Branson
$369

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Sat 1/31

3:46 pm-11:31 pm

1 stop9h 45m

San Diego

Fri 2/6

8:16 pm-2:46 pm

1 stop16h 30m

$109

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Sat 2/21

8:36 pm-8:24 am

1 stop13h 48m

San Diego

Mon 2/23

6:25 am-7:48 pm

1 stop11h 23m

$110

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Mon 2/2

1:40 pm-12:08 am

1 stop12h 28m

San Diego

Fri 2/6

8:16 pm-2:46 pm

1 stop16h 30m

$110

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Mon 1/26

1:40 pm-12:08 am

1 stop12h 28m

San Diego

Fri 1/30

6:30 am-6:44 pm

1 stop10h 14m

$114

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 2/3

8:45 am-3:04 pm

1 stop8h 19m

San Diego

Sat 2/7

11:10 am-8:33 pm

1 stop7h 23m

$278

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 2/3

8:45 am-12:59 pm

1 stop6h 14m

San Diego

Sat 2/7

6:15 am-8:33 pm

2 stops12h 18m

$284

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Mon 1/26

9:42 pm-11:31 pm

2 stops27h 49m

San Diego

Thu 2/5

2:56 pm-8:52 pm

1 stop27h 56m

$286

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Wed 2/18

7:34 am-2:29 pm

1 stop8h 55m

San Diego

Sat 2/21

10:35 pm-10:08 am

1 stop9h 33m

$289

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Sun 1/25

5:00 pm-10:45 pm

1 stop7h 45m

San Diego

Wed 2/4

6:30 am-4:15 pm

1 stop7h 45m

$314

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Fri 1/23

9:42 pm-10:25 am

2 stops38h 43m

San Diego

Thu 2/5

2:56 pm-8:52 pm

1 stop27h 56m

$317

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Missouri to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Missouri during the month September is also very affordable. Most momondo users find prices during this month for around $324.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Missouri to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $427. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $542. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $461. Flights at noon are often more expensive with an average ticket price of $601.

What is the cheapest Missouri to San Diego flight route?

Fly from Lambert-St Louis to San Diego for the best Missouri - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $381 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Missouri for as low as $330 on momondo.

What cabin class options are available on Missouri to San Diego flights?

There is only 1 cabin class available to choose from on Missouri to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Missouri to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to San Diego

Best Price Found

$322

Fastest flight time

3h 15m

Direct flights

Every day

Airports in San Diego

1 airport
The best one-way flight to San Diego from Missouri in the past 72 hours is $322. The best round-trip flight deal from Missouri to San Diego found on momondo in the last 72 hours is $398.
The fastest flight from Missouri to San Diego takes 3h 15m
Direct flights go from Missouri to San Diego every day.
There is 1 airport in San Diego. From Missouri there are direct flights to San Diego (SAN).
Search flight deals

  • When did momondo last update prices for flights from Missouri to San Diego Airport?

    Prices for flights from Missouri to San Diego Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to San Diego Airport?

  • How old do you have to be to fly from Missouri to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents required for your trip to San Diego Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Diego Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Missouri to San Diego?

Best airlines flying from Missouri to San Diego

Compare and see reviews for airlines that fly from Missouri to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $109Free CancellationRating
5.7
3,061 reviews
Search Frontier flights
Spirit AirlinesPriceFrom $125Free CancellationRating
6.3
8,289 reviews
Search Spirit Airlines flights
United AirlinesPriceFrom $182Free CancellationRating
7.4
9,142 reviews
Search United Airlines flights
American AirlinesPriceFrom $225Free CancellationRating
7.2
11,097 reviews
Search American Airlines flights
Alaska AirlinesPriceFrom $228Free CancellationRating
8.0
11,672 reviews
Search Alaska Airlines flights
DeltaPriceFrom $242Free CancellationRating
7.9
8,032 reviews
Search Delta flights
SouthwestPriceFrom $266Free CancellationRating
8.0
4,250 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
Poway
National City
Imperial Beach
Borrego Springs
La Mesa
San Ysidro
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Missouri with this policy.

How can momondo help me find flights from Missouri to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Missouri.

I’m not ready to book a flight from Missouri to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Missouri. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your San Diego trip

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