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Cheap flights from Knoxville to San Luis Obispo from $342

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Luis Obispo departing on 11/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Knoxville to San Luis Obispo

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
4:55 pm - 9:08 pmTYS-SBP
7h 13m1 stop
United Airlines Logo
7:26 am - 9:04 pmSBP-TYS
10h 38m2 stops
$342United Airlines
Find Deal
Fri, Nov 21 - Wed, Dec 3
American Airlines Logo
5:10 am - 11:43 amTYS-SBP
9h 33m1 stop
American Airlines Logo
12:28 pm - 11:59 pmSBP-TYS
8h 31m1 stop
$349American Airlines
Find Deal
Fri, Nov 21 - Wed, Dec 3
American Airlines Logo
6:30 am - 3:45 pmTYS-SBP
12h 15m2 stops
American Airlines Logo
9:55 am - 11:57 pmSBP-TYS
11h 02m2 stops
$369American Airlines
Find Deal
Thu, Nov 27 - Thu, Dec 4
United Airlines Logo
4:55 pm - 9:08 pmTYS-SBP
7h 13m1 stop
United Airlines Logo
7:26 am - 9:04 pmSBP-TYS
10h 38m2 stops
$382United Airlines
Find Deal
Tue, Nov 25 - Wed, Dec 3
United Airlines Logo
4:55 pm - 9:08 pmTYS-SBP
7h 13m1 stop
United Airlines Logo
5:02 am - 3:07 pmSBP-TYS
7h 05m1 stop
$399United Airlines
Find Deal
Tue, Nov 25 - Wed, Dec 3
American Airlines Logo
5:46 am - 12:00 pmTYS-SBP
9h 14m1 stop
American Airlines Logo
12:45 pm - 12:13 amSBP-TYS
8h 28m1 stop
$409American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
5:10 am - 12:12 pmTYS-SBP
10h 02m2 stops
American Airlines Logo
12:28 pm - 11:59 pmSBP-TYS
8h 31m1 stop
$414American Airlines
Find Deal
Sun, Nov 23 - Wed, Dec 3
American Airlines Logo
5:10 am - 12:12 pmTYS-SBP
10h 02m2 stops
American Airlines Logo
9:55 am - 10:55 pmSBP-TYS
10h 00m2 stops
$419American Airlines
Find Deal
Sun, Nov 23 - Fri, Dec 5
United Airlines Logo
8:50 am - 5:26 pmTYS-SBP
11h 36m2 stops
United Airlines Logo
7:26 am - 9:04 pmSBP-TYS
10h 38m2 stops
$421United Airlines
Find Deal
Fri, Nov 21 - Wed, Dec 3
United Airlines Logo
8:26 am - 5:26 pmTYS-SBP
12h 00m2 stops
United Airlines Logo
7:26 am - 9:04 pmSBP-TYS
10h 38m2 stops
$449United Airlines
Find Deal
Sun, Nov 23 - Wed, Dec 3

American Airlines flights from Knoxville to San Luis Obispo

Our best American Airlines deals on Knoxville to San Luis Obispo flight tickets
American Airlines
Nov 21
TYS5:10 amKnoxville McGhee Tyson
9h 33m
1 stop
SBP11:43 amSan Luis Obispo County
Dec 3
SBP12:28 pmSan Luis Obispo County
8h 31m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$349
Find similar
American Airlines
Nov 27
TYS6:30 amKnoxville McGhee Tyson
12h 15m
2 stops
SBP3:45 pmSan Luis Obispo County
Dec 4
SBP9:55 amSan Luis Obispo County
11h 02m
2 stops
TYS11:57 pmKnoxville McGhee Tyson
$369
Find similar
American Airlines
Feb 21
TYS5:46 amKnoxville McGhee Tyson
9h 14m
1 stop
SBP12:00 pmSan Luis Obispo County
Feb 25
SBP12:45 pmSan Luis Obispo County
8h 28m
1 stop
TYS12:13 amKnoxville McGhee Tyson
$409
Find similar

United Airlines flights from Knoxville to San Luis Obispo

Our best United Airlines deals on Knoxville to San Luis Obispo flight tickets
United Airlines
Nov 21
TYS4:55 pmKnoxville McGhee Tyson
7h 13m
1 stop
SBP9:08 pmSan Luis Obispo County
Dec 3
SBP7:26 amSan Luis Obispo County
10h 38m
2 stops
TYS9:04 pmKnoxville McGhee Tyson
$342
Find similar
United Airlines
Oct 31
TYS4:58 pmKnoxville McGhee Tyson
7h 10m
1 stop
SBP9:08 pmSan Luis Obispo County
Nov 18
SBP5:15 amSan Luis Obispo County
6h 28m
1 stop
TYS2:43 pmKnoxville McGhee Tyson
$359
Find similar
United Airlines
Oct 31
TYS4:58 pmKnoxville McGhee Tyson
7h 10m
1 stop
SBP9:08 pmSan Luis Obispo County
Nov 18
SBP7:04 amSan Luis Obispo County
10h 29m
2 stops
TYS8:33 pmKnoxville McGhee Tyson
$364
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Luis Obispo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Knoxville to San Luis Obispo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSan Luis Obispo

TYS - SBP

TYSSBP

Knoxville McGhee Tyson

Fri 11/21

4:55 pm-9:08 pm

1 stop7h 13m

San Luis Obispo County

Wed 12/3

7:26 am-9:04 pm

2 stops10h 38m

$342

KnoxvilleSan Luis Obispo

TYS - SBP

TYSSBP

Knoxville McGhee Tyson

Fri 11/21

5:10 am-11:43 am

1 stop9h 33m

San Luis Obispo County

Wed 12/3

12:28 pm-11:59 pm

1 stop8h 31m

$349

KnoxvilleSan Luis Obispo

TYS - SBP

TYSSBP

Knoxville McGhee Tyson

Thu 11/27

6:30 am-3:45 pm

2 stops12h 15m

San Luis Obispo County

Thu 12/4

9:55 am-11:57 pm

2 stops11h 02m

$369

KnoxvilleSan Luis Obispo

TYS - SBP

TYSSBP

Knoxville McGhee Tyson

Tue 11/25

4:55 pm-9:08 pm

1 stop7h 13m

San Luis Obispo County

Wed 12/3

7:26 am-9:04 pm

2 stops10h 38m

$382

KnoxvilleSan Luis Obispo

TYS - SBP

TYSSBP

Knoxville McGhee Tyson

Tue 11/25

4:55 pm-9:08 pm

1 stop7h 13m

San Luis Obispo County

Wed 12/3

5:02 am-3:07 pm

1 stop7h 05m

$399

KnoxvilleSan Luis Obispo

TYS - SBP

TYSSBP

Knoxville McGhee Tyson

Sat 2/21

5:46 am-12:00 pm

1 stop9h 14m

San Luis Obispo County

Wed 2/25

12:45 pm-12:13 am

1 stop8h 28m

$409

KnoxvilleSan Luis Obispo

TYS - SBP

TYSSBP

Knoxville McGhee Tyson

Sun 11/23

5:10 am-12:12 pm

2 stops10h 02m

San Luis Obispo County

Wed 12/3

12:28 pm-11:59 pm

1 stop8h 31m

$414

KnoxvilleSan Luis Obispo

TYS - SBP

TYSSBP

Knoxville McGhee Tyson

Sun 11/23

5:10 am-12:12 pm

2 stops10h 02m

San Luis Obispo County

Fri 12/5

9:55 am-10:55 pm

2 stops10h 00m

$419

KnoxvilleSan Luis Obispo

TYS - SBP

TYSSBP

Knoxville McGhee Tyson

Fri 11/21

8:50 am-5:26 pm

2 stops11h 36m

San Luis Obispo County

Wed 12/3

7:26 am-9:04 pm

2 stops10h 38m

$421

KnoxvilleSan Luis Obispo

TYS - SBP

TYSSBP

Knoxville McGhee Tyson

Sun 11/23

8:26 am-5:26 pm

2 stops12h 00m

San Luis Obispo County

Wed 12/3

7:26 am-9:04 pm

2 stops10h 38m

$449

Flights are sorted by cheapest round-trip flights first.

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How to get the cheapest flight ticket from Knoxville to San Luis Obispo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to San Luis Obispo?

On average, the least expensive day to fly to San Luis Obispo from Knoxville is on a Saturday. momondo users have found tickets for Saturday departures for as low as $308. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Knoxville to San Luis Obispo for around $658.

What is the cheapest time of day to depart on your flight to San Luis Obispo?

Flying to San Luis Obispo from Knoxville in the morning is the least expensive time of day to depart. momondo users have found prices as low as $474 when looking at flights departing in the morning. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $628 on average. Flights to San Luis Obispo from Knoxville in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

When to book flights from Knoxville to San Luis Obispo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Luis Obispo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Luis Obispo (TYS to SBP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Luis Obispo

Direct flights

None
There are no direct flights from Knoxville to San Luis Obispo. There are no popular flight routes from Knoxville to San Luis Obispo.
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  • How far is Knoxville McGhee Tyson to San Luis Obispo County by plane?

    San Luis Obispo County is 2050.2 mi away from Knoxville McGhee Tyson. Flights usually cover this in 7h 13m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Luis Obispo County Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Luis Obispo County Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Luis Obispo County Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Luis Obispo County Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Luis Obispo County Airport.

  • What documentation or ID do you need to fly to San Luis Obispo County Airport?

    The required travel and health documents for your San Luis Obispo County Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Luis Obispo County Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Luis Obispo?

Best airlines flying from Knoxville to San Luis Obispo

Compare and see reviews for airlines that fly from Knoxville to San Luis Obispo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,034 reviews
Search American Airlines flights

Traveling to a place near San Luis Obispo?

Book flights to San Luis Obispo if you plan to visit one of these locations
Pismo Beach
Morro Bay
Paso Robles
Cambria
Avila Beach
San Simeon
Cayucos
Arroyo Grande
Atascadero
Grover Beach

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Luis Obispo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Luis Obispo from Knoxville.

Can I find flights from Knoxville to San Luis Obispo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Luis Obispo from Knoxville with this policy.

How can momondo help me find flights from Knoxville to San Luis Obispo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Luis Obispo from Knoxville.

I’m not ready to book a flight from Knoxville to San Luis Obispo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to San Luis Obispo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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