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Cheap flights from Knoxville to San Francisco from $136

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Francisco departing on 6/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:32 pm - 8:50 pm
TYS
-
SFO
27h 18m
1 stop
Frontier Logo
6:00 am - 7:37 pm
SFO
-
TYS
10h 37m
1 stop
$219Frontier
Wed, Aug 19 - Wed, Aug 26
Frontier Logo
8:32 pm - 11:36 am
TYS
-
SFO
18h 04m
1 stop
Frontier Logo
12:33 pm - 7:36 pm
SFO
-
TYS
28h 03m
1 stop
$260Frontier
Mon, Aug 10 - Sun, Aug 16
Frontier Logo
8:32 pm - 8:54 pm
TYS
-
SFO
27h 22m
1 stop
Frontier Logo
6:00 am - 7:36 pm
SFO
-
TYS
10h 36m
1 stop
$280Frontier
Wed, Jul 15 - Mon, Jul 20
Frontier Logo
8:32 pm - 8:01 am
TYS
-
SFO
14h 29m
1 stop
Frontier Logo
6:00 am - 7:33 pm
SFO
-
TYS
10h 33m
1 stop
$281Frontier
Fri, Jun 5 - Mon, Jun 8
Frontier Logo
8:19 pm - 12:23 am
TYS
-
SFO
7h 04m
1 stop
Frontier Logo
6:00 am - 7:24 pm
SFO
-
TYS
10h 24m
1 stop
$290Frontier
Fri, May 22 - Mon, May 25
Frontier Logo
8:19 pm - 12:23 am
TYS
-
SFO
7h 04m
1 stop
Frontier Logo
6:00 am - 7:24 pm
SFO
-
TYS
10h 24m
1 stop
$300Frontier
Fri, May 22 - Mon, May 25
Frontier Logo
8:19 pm - 12:23 am
TYS
-
SFO
7h 04m
1 stop
Frontier Logo
6:00 am - 7:24 pm
SFO
-
TYS
10h 24m
1 stop
$320Frontier
Fri, May 22 - Mon, May 25
Multiple Airlines Logo
2:51 pm - 4:06 pm
TYS
-
SFO
28h 15m
1 stop
Multiple Airlines Logo
9:35 pm - 1:49 pm
SFO
-
TYS
13h 14m
1 stop
$332Multiple Airlines
Sun, Aug 16 - Sat, Aug 22
Frontier Logo
8:19 pm - 8:01 am
TYS
-
SFO
14h 42m
1 stop
Frontier Logo
6:00 am - 7:33 pm
SFO
-
TYS
10h 33m
1 stop
$336Frontier
Fri, May 29 - Fri, Jun 5
Frontier Logo
8:32 pm - 8:54 pm
TYS
-
SFO
27h 22m
1 stop
Frontier Logo
6:00 am - 7:36 pm
SFO
-
TYS
10h 36m
1 stop
$345Frontier
Wed, Jul 15 - Mon, Jul 20

Delta flights from Knoxville to San Francisco

Our best Delta deals on Knoxville to San Francisco flight tickets
Delta
Jul 14
TYS5:40 amKnoxville McGhee Tyson
7h 40m
1 stop
SFO10:20 amSan Francisco
Jul 20
SFO10:59 pmSan Francisco
7h 37m
1 stop
TYS9:36 amKnoxville McGhee Tyson
$399
Delta
Jun 17
TYS6:45 amKnoxville McGhee Tyson
7h 50m
1 stop
SFO11:35 amSan Francisco
Jun 27
SFO11:59 pmSan Francisco
6h 39m
1 stop
TYS9:38 amKnoxville McGhee Tyson
$424
Delta
May 21
TYS11:44 amKnoxville McGhee Tyson
9h 05m
1 stop
SFO5:49 pmSan Francisco
May 26
SFO11:59 pmSan Francisco
7h 22m
1 stop
TYS10:21 amKnoxville McGhee Tyson
$554

Frontier flights from Knoxville to San Francisco

Our best Frontier deals on Knoxville to San Francisco flight tickets
Frontier
Aug 19
TYS8:32 pmKnoxville McGhee Tyson
27h 18m
1 stop
SFO8:50 pmSan Francisco
Aug 26
SFO6:00 amSan Francisco
10h 37m
1 stop
TYS7:37 pmKnoxville McGhee Tyson
$219
Frontier
Aug 10
TYS8:32 pmKnoxville McGhee Tyson
18h 04m
1 stop
SFO11:36 amSan Francisco
Aug 16
SFO12:33 pmSan Francisco
28h 03m
1 stop
TYS7:36 pmKnoxville McGhee Tyson
$260
Frontier
Jul 15
TYS8:32 pmKnoxville McGhee Tyson
27h 22m
1 stop
SFO8:54 pmSan Francisco
Jul 20
SFO6:00 amSan Francisco
10h 36m
1 stop
TYS7:36 pmKnoxville McGhee Tyson
$280

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 8/19

8:32 pm-8:50 pm

1 stop27h 18m

San Francisco

Wed 8/26

6:00 am-7:37 pm

1 stop10h 37m

$219

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 8/10

8:32 pm-11:36 am

1 stop18h 04m

San Francisco

Sun 8/16

12:33 pm-7:36 pm

1 stop28h 03m

$260

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 7/15

8:32 pm-8:54 pm

1 stop27h 22m

San Francisco

Mon 7/20

6:00 am-7:36 pm

1 stop10h 36m

$280

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 6/5

8:32 pm-8:01 am

1 stop14h 29m

San Francisco

Mon 6/8

6:00 am-7:33 pm

1 stop10h 33m

$281
Quickest round-trip

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 5/22

8:19 pm-12:23 am

1 stop7h 04m

San Francisco

Mon 5/25

6:00 am-7:24 pm

1 stop10h 24m

$290

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 5/22

8:19 pm-12:23 am

1 stop7h 04m

San Francisco

Mon 5/25

6:00 am-7:24 pm

1 stop10h 24m

$300

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 5/22

8:19 pm-12:23 am

1 stop7h 04m

San Francisco

Mon 5/25

6:00 am-7:24 pm

1 stop10h 24m

$320

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sun 8/16

2:51 pm-4:06 pm

1 stop28h 15m

San Francisco

Sat 8/22

9:35 pm-1:49 pm

1 stop13h 14m

$332

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 5/29

8:19 pm-8:01 am

1 stop14h 42m

San Francisco

Fri 6/5

6:00 am-7:33 pm

1 stop10h 33m

$336

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 7/15

8:32 pm-8:54 pm

1 stop27h 22m

San Francisco

Mon 7/20

6:00 am-7:36 pm

1 stop10h 36m

$345

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Knoxville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of February, then flying in July is also cheap. Prices for this month can be found on momondo for an average of $398.

How far in advance should I book a flight from Knoxville to San Francisco?

You are more likely to see cheaper flights to San Francisco from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $463 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Knoxville for as low as $274 on momondo.

How have Knoxville to San Francisco flight prices changed over time?

As of May 2026, prices for Knoxville to San Francisco flights are approximately 15% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Francisco (TYS to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Francisco

Fastest flight time

7h 23m

Direct flights

None
The fastest flight from Knoxville to San Francisco takes 7h 23m
There are no direct flights from Knoxville to San Francisco. There are no popular flight routes from Knoxville to San Francisco.
Search flight deals

Frequently asked questions about flying from Knoxville to San Francisco

  • How far is Knoxville McGhee Tyson to San Francisco by plane?

    San Francisco is 2114.2 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 7h 23m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Francisco?

Best airlines flying from Knoxville to San Francisco

Compare and see reviews for airlines that fly from Knoxville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $184Free CancellationRating
5.6
2,955 reviews
Search Frontier flights
DeltaPriceFrom $256Free CancellationRating
7.9
8,453 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.1
11,670 reviews
Search American Airlines flights
United AirlinesPriceFrom $321Free CancellationRating
7.4
9,700 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Roseville
Berkeley
Hayward
Santa Clara
Fremont
Vallejo
Big Sur
Calistoga
Sunnyvale
South San Francisco
Salinas
Daly City
Half Moon Bay
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Francisco?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to San Francisco. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to San Francisco with flexible booking policies on momondo?

Flights from Knoxville to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to San Francisco right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to San Francisco flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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