Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to San Francisco from $97

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:30 am - 12:20 amTYS  Knoxville McGhee Tyson-SFO San Francisco
20h 50m1 stop Denver Intl
Multiple Airlines Logo
11:52 pm - 11:38 amSFO  San Francisco-TYS Knoxville McGhee Tyson
32h 46m2 stops Dallas/Fort Worth Washington, D.C. Dulles Intl
$239Multiple Airlines
Thu, Oct 29 - Tue, Nov 3
Multiple Airlines Logo
9:29 pm - 8:13 amTYS  Knoxville McGhee Tyson-SFO San Francisco
13h 44m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
11:52 pm - 11:29 amSFO  San Francisco-TYS Knoxville McGhee Tyson
32h 37m2 stops Dallas/Fort Worth Washington, D.C. Dulles Intl
$249Multiple Airlines
Thu, Oct 22 - Tue, Oct 27
Multiple Airlines Logo
9:29 pm - 8:13 amTYS  Knoxville McGhee Tyson-SFO San Francisco
13h 44m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
7:14 pm - 8:39 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
22h 25m1 stop Las Vegas Harry Reid Intl
$264Multiple Airlines
Thu, Oct 22 - Wed, Oct 28
American Airlines Logo
5:30 am - 10:16 amTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 46m1 stop Dallas/Fort Worth
American Airlines Logo
5:00 am - 4:48 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
8h 48m1 stop Charlotte Douglas
$377American Airlines
Wed, Nov 11 - Wed, Nov 18
American Airlines Logo
7:30 am - 12:23 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 53m1 stop Charlotte Douglas
American Airlines Logo
5:00 am - 3:23 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 23m1 stop Charlotte Douglas
$377American Airlines
Sat, Nov 7 - Tue, Nov 10
United Airlines Logo
6:45 am - 11:50 amTYS  Knoxville McGhee Tyson-SFO San Francisco
8h 05m1 stop Chicago O'Hare Intl
United Airlines Logo
5:00 am - 3:01 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 01m1 stop Denver Intl
$377United Airlines
Tue, Oct 27 - Tue, Nov 3
United Airlines Logo
7:00 am - 12:19 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
8h 19m1 stop Houston George Bush Intcntl
United Airlines Logo
5:00 am - 4:04 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
8h 04m1 stop Denver Intl
$377United Airlines
Tue, Nov 3 - Sat, Nov 7
Delta Logo
8:09 am - 12:20 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 11m1 stop Minneapolis St Paul
Delta Logo
6:00 am - 3:15 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
6h 15m1 stop Atlanta Hartsfield-Jackson
$377Delta
Tue, Oct 20 - Thu, Nov 12
Delta Logo
11:45 am - 6:17 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 32m1 stop Detroit Metropolitan Wayne County
Delta Logo
10:25 pm - 10:45 amSFO  San Francisco-TYS Knoxville McGhee Tyson
9h 20m1 stop Atlanta Hartsfield-Jackson
$377Delta
Thu, Oct 29 - Tue, Nov 3
American Airlines Logo
12:53 pm - 8:24 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
10h 31m1 stop Charlotte Douglas
American Airlines Logo
12:39 pm - 11:32 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 53m1 stop Dallas/Fort Worth
$377American Airlines
Thu, Oct 29 - Mon, Nov 2

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Southwest flights from Knoxville to San Francisco

Our best Southwest deals on Knoxville to San Francisco flight tickets
Southwest
Nov 14
TYS5:20 pmKnoxville McGhee Tyson
7h 15m
1 stop
SFO9:35 pmSan Francisco
Nov 17
SFO6:10 amSan Francisco
10h 40m
2 stops
TYS7:50 pmKnoxville McGhee Tyson
$382
Southwest
Nov 14
TYS7:10 amKnoxville McGhee Tyson
10h 20m
2 stops
SFO2:30 pmSan Francisco
Nov 17
SFO6:10 amSan Francisco
10h 40m
2 stops
TYS7:50 pmKnoxville McGhee Tyson
$387
Southwest
Nov 3
TYS7:55 amKnoxville McGhee Tyson
8h 55m
1 stop
SFO1:50 pmSan Francisco
Nov 7
SFO6:00 pmSan Francisco
18h 00m
2 stops
TYS3:00 pmKnoxville McGhee Tyson
$393

American Airlines flights from Knoxville to San Francisco

Our best American Airlines deals on Knoxville to San Francisco flight tickets
American Airlines
Nov 11
TYS5:30 amKnoxville McGhee Tyson
7h 46m
1 stop
SFO10:16 amSan Francisco
Nov 18
SFO5:00 amSan Francisco
8h 48m
1 stop
TYS4:48 pmKnoxville McGhee Tyson
$377
American Airlines
Nov 25
TYS7:30 pmKnoxville McGhee Tyson
8h 17m
1 stop
SFO12:47 amSan Francisco
Dec 1
SFO11:15 amSan Francisco
9h 17m
1 stop
TYS11:32 pmKnoxville McGhee Tyson
$380
American Airlines
Nov 11
TYS5:30 amKnoxville McGhee Tyson
7h 46m
1 stop
SFO10:16 amSan Francisco
Nov 18
SFO5:00 amSan Francisco
8h 48m
1 stop
TYS4:48 pmKnoxville McGhee Tyson
$383

momondo Fare Finder

 
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Thu 10/29

6:30 am-12:20 am

1 stop20h 50m

San Francisco

Tue 11/3

11:52 pm-11:38 am

2 stops32h 46m

$239

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Thu 10/22

9:29 pm-8:13 am

1 stop13h 44m

San Francisco

Tue 10/27

11:52 pm-11:29 am

2 stops32h 37m

$249

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Thu 10/22

9:29 pm-8:13 am

1 stop13h 44m

San Francisco

Wed 10/28

7:14 pm-8:39 pm

1 stop22h 25m

$264

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Wed 11/11

5:30 am-10:16 am

1 stop7h 46m

San Francisco

Wed 11/18

5:00 am-4:48 pm

1 stop8h 48m

$377

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Sat 11/7

7:30 am-12:23 pm

1 stop7h 53m

San Francisco

Tue 11/10

5:00 am-3:23 pm

1 stop7h 23m

$377

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Tue 10/27

6:45 am-11:50 am

1 stop8h 05m

San Francisco

Tue 11/3

5:00 am-3:01 pm

1 stop7h 01m

$377

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Tue 11/3

7:00 am-12:19 pm

1 stop8h 19m

San Francisco

Sat 11/7

5:00 am-4:04 pm

1 stop8h 04m

$377
Quickest round-trip

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Tue 10/20

8:09 am-12:20 pm

1 stop7h 11m

San Francisco

Thu 11/12

6:00 am-3:15 pm

1 stop6h 15m

$377

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Thu 10/29

11:45 am-6:17 pm

1 stop9h 32m

San Francisco

Tue 11/3

10:25 pm-10:45 am

1 stop9h 20m

$377

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Thu 10/29

12:53 pm-8:24 pm

1 stop10h 31m

San Francisco

Mon 11/2

12:39 pm-11:32 pm

1 stop7h 53m

$377

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Francisco from

How to get the cheapest flight ticket from Knoxville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and San Francisco?

Prices are currently low for flights on this route.

Typical prices usually range from $362 to $607.
The lowest price recently found on this route was $239.

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of February, then flying in April is also cheap. Prices for this month can be found on momondo for an average of $429.

How far in advance should I book a flight from Knoxville to San Francisco?

You are more likely to see cheaper flights to San Francisco from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $503 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Knoxville for as low as $292 on momondo.

How have Knoxville to San Francisco flight prices changed over time?

As of October 2026, prices for Knoxville to San Francisco flights are approximately 28% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Francisco (TYS to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Francisco

Best Price Found

$97

Fastest flight time

8h 03m

Direct flights

None
The best one-way flight to San Francisco from Knoxville in the past 72 hours is $97. The best round-trip flight deal from Knoxville to San Francisco found on momondo in the last 72 hours is $239.
The fastest flight from Knoxville to San Francisco takes 8h 03m
There are no direct flights from Knoxville to San Francisco. There are no popular flight routes from Knoxville to San Francisco.
Search flight deals

Frequently asked questions about flying from Knoxville to San Francisco

  • How far is Knoxville McGhee Tyson to San Francisco by plane?

    San Francisco is 2114.2 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 8h 03m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Francisco?

Best airlines flying from Knoxville to San Francisco

Compare and see reviews for airlines that fly from Knoxville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $131Free CancellationRating
5.6
2,563 reviews
Search Frontier flights
JetBluePriceFrom $317Free CancellationRating
7.1
3,044 reviews
Search JetBlue flights
American AirlinesPriceFrom $325Free CancellationRating
7.0
12,130 reviews
Search American Airlines flights
United AirlinesPriceFrom $326Free CancellationRating
7.4
10,283 reviews
Search United Airlines flights
DeltaPriceFrom $328Free CancellationRating
7.8
8,626 reviews
Search Delta flights

  • United Airlines Flights From Knoxville to San Francisco

    The lowest priced United Airlines flight from Knoxville to San Francisco from the last 72 hours was $326. Generally, United Airlines has 4 flights on this route every week with an average price of $494. United Airlines is rated 7.4/10 by our users.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Hayward
Berkeley
Bodega Bay
Fremont
Walnut Creek
Santa Clara
Sunnyvale
Vallejo
Half Moon Bay
Roseville
Salinas
Sonoma
Milpitas
Daly City
Pacific Grove
Palo Alto

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Francisco?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to San Francisco. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to San Francisco with flexible booking policies on momondo?

Flights from Knoxville to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to San Francisco right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to San Francisco flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Mon 11/2
Mon 11/9
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States