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Cheap flights from Knoxville to San Francisco from $139

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Francisco departing on 8/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to San Francisco

Cheap round-trip flights

Frontier Logo
8:40 pm - 7:45 amTYS-SFO
14h 05m1 stop
Frontier Logo
10:49 am - 4:18 pmSFO-TYS
26h 29m1 stop
$267Frontier
Find Deal
Thu, Sep 4 - Sat, Sep 6
Frontier Logo
8:40 pm - 12:16 amTYS-SFO
6h 36m1 stop
Frontier Logo
6:29 am - 4:18 pmSFO-TYS
6h 49m1 stop
$278Frontier
Find Deal
Thu, Oct 2 - Sun, Oct 5
Delta Logo
6:14 pm - 10:49 pmTYS-SFO
7h 35m1 stop
Delta Logo
6:15 am - 5:19 pmSFO-TYS
8h 04m1 stop
$309Delta
Find Deal
Fri, Aug 22 - Wed, Aug 27
American Airlines Logo
6:08 pm - 10:48 pmTYS-SFO
7h 40m1 stop
American Airlines Logo
12:50 am - 11:44 amSFO-TYS
7h 54m1 stop
$339American Airlines
Find Deal
Thu, Oct 2 - Sun, Oct 19
American Airlines Logo
4:37 pm - 9:05 pmTYS-SFO
7h 28m1 stop
American Airlines Logo
11:55 pm - 11:44 amSFO-TYS
8h 49m1 stop
$341American Airlines
Find Deal
Sat, Oct 4 - Sat, Oct 11
Delta Logo
1:52 pm - 5:32 pmTYS-SFO
6h 40m1 stop
Delta Logo
10:30 am - 11:44 pmSFO-TYS
10h 14m2 stops
$367Delta
Find Deal
Fri, Sep 19 - Tue, Sep 23
United Airlines Logo
4:40 pm - 9:03 pmTYS-SFO
7h 23m1 stop
United Airlines Logo
12:43 am - 1:38 pmSFO-TYS
9h 55m1 stop
$409United Airlines
Find Deal
Wed, Sep 3 - Fri, Sep 5
United Airlines Logo
7:00 am - 6:59 pmTYS-SFO
14h 59m2 stops
United Airlines Logo
12:43 am - 1:38 pmSFO-TYS
9h 55m1 stop
$414United Airlines
Find Deal
Wed, Sep 3 - Fri, Sep 5
Logo
7:00 am - 5:18 pmTYS-SFO
13h 18m2 stops
Logo
5:39 pm - 5:34 pmSFO-TYS
20h 55m2 stops
$526
Find Deal
Thu, Sep 25 - Sun, Sep 28
Logo
9:12 pm - 10:51 pmTYS-SFO
28h 39m3 stops
Logo
6:18 pm - 5:34 pmSFO-TYS
20h 16m2 stops
$536
Find Deal
Thu, Aug 28 - Thu, Sep 4

Delta flights from Knoxville to San Francisco

Our best Delta deals on Knoxville to San Francisco flight tickets
Delta
Aug 22
TYS6:14 pmKnoxville McGhee Tyson
7h 35m
1 stop
SFO10:49 pmSan Francisco
Aug 27
SFO6:15 amSan Francisco
8h 04m
1 stop
TYS5:19 pmKnoxville McGhee Tyson
$309
Find similar
Delta
Sep 19
TYS1:52 pmKnoxville McGhee Tyson
6h 40m
1 stop
SFO5:32 pmSan Francisco
Sep 23
SFO10:30 amSan Francisco
10h 14m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
$367
Find similar
Delta
Aug 5
TYS5:12 pmKnoxville McGhee Tyson
8h 18m
1 stop
SFO10:30 pmSan Francisco
Aug 12
SFO6:15 amSan Francisco
9h 20m
1 stop
TYS6:35 pmKnoxville McGhee Tyson
$407
Find similar

United Airlines flights from Knoxville to San Francisco

Our best United Airlines deals on Knoxville to San Francisco flight tickets
United Airlines
Sep 3
TYS4:40 pmKnoxville McGhee Tyson
7h 23m
1 stop
SFO9:03 pmSan Francisco
Sep 5
SFO12:43 amSan Francisco
9h 55m
1 stop
TYS1:38 pmKnoxville McGhee Tyson
$409
Find similar
United Airlines
Sep 3
TYS7:00 amKnoxville McGhee Tyson
14h 59m
2 stops
SFO6:59 pmSan Francisco
Sep 5
SFO12:43 amSan Francisco
9h 55m
1 stop
TYS1:38 pmKnoxville McGhee Tyson
$414
Find similar
United Airlines
Sep 4
TYS9:30 amKnoxville McGhee Tyson
8h 05m
1 stop
SFO2:35 pmSan Francisco
Sep 8
SFO12:43 amSan Francisco
9h 55m
1 stop
TYS1:38 pmKnoxville McGhee Tyson
$439
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 9/4

8:40 pm-7:45 am

1 stop14h 05m

San Francisco

Sat 9/6

10:49 am-4:18 pm

1 stop26h 29m

$267

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 10/2

8:40 pm-12:16 am

1 stop6h 36m

San Francisco

Sun 10/5

6:29 am-4:18 pm

1 stop6h 49m

$278

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 8/22

6:14 pm-10:49 pm

1 stop7h 35m

San Francisco

Wed 8/27

6:15 am-5:19 pm

1 stop8h 04m

$309

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 10/2

6:08 pm-10:48 pm

1 stop7h 40m

San Francisco

Sun 10/19

12:50 am-11:44 am

1 stop7h 54m

$339

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sat 10/4

4:37 pm-9:05 pm

1 stop7h 28m

San Francisco

Sat 10/11

11:55 pm-11:44 am

1 stop8h 49m

$341

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 9/19

1:52 pm-5:32 pm

1 stop6h 40m

San Francisco

Tue 9/23

10:30 am-11:44 pm

2 stops10h 14m

$367

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 9/3

4:40 pm-9:03 pm

1 stop7h 23m

San Francisco

Fri 9/5

12:43 am-1:38 pm

1 stop9h 55m

$409

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 9/3

7:00 am-6:59 pm

2 stops14h 59m

San Francisco

Fri 9/5

12:43 am-1:38 pm

1 stop9h 55m

$414

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 9/25

7:00 am-5:18 pm

2 stops13h 18m

San Francisco

Sun 9/28

5:39 pm-5:34 pm

2 stops20h 55m

$526

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 8/28

9:12 pm-10:51 pm

3 stops28h 39m

San Francisco

Thu 9/4

6:18 pm-5:34 pm

2 stops20h 16m

$536

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Knoxville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of September, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $363.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Knoxville to San Francisco is on a Tuesday when prices can be found for as low as $408. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $555.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Knoxville to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $360. Flights in the morning are often more expensive with an average ticket price of $508.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $414 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Knoxville for as low as $325 on momondo.

How have Knoxville to San Francisco flight prices changed over time?

As of July 2025, prices for Knoxville to San Francisco flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Francisco (TYS to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Francisco

Best Price Found

$139

Fastest flight time

6h 36m

Direct flights

None

Airports in San Francisco

1 airport
The best one-way flight to San Francisco from Knoxville in the past 72 hours is $139. The best round-trip flight deal from Knoxville to San Francisco found on momondo in the last 72 hours is $267.
The fastest flight from Knoxville to San Francisco takes 6h 36m
There are no direct flights from Knoxville to San Francisco. Popular non-direct route for this connection is Knoxville McGhee Tyson Airport - San Francisco Airport.
There is 1 airport near San Francisco: San Francisco (SFO)
Search flight deals

  • How far is Knoxville McGhee Tyson to San Francisco by plane?

    San Francisco is 2114.7 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 6h 36m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Francisco?

Best airlines flying from Knoxville to San Francisco

Compare and see reviews for airlines that fly from Knoxville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $155Free CancellationRating
5.9
3,239 reviews
Search Frontier flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $308Free CancellationRating
8.0
7,981 reviews
Search Delta flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Calistoga
Hayward
Bodega Bay
Sonoma
Roseville
Santa Clara
Big Sur
Daly City
Berkeley
Walnut Creek
Fremont
Half Moon Bay
South San Francisco
Redwood City
Vallejo
Sunnyvale
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Francisco?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to San Francisco. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to San Francisco with flexible booking policies on momondo?

Flights from Knoxville to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to San Francisco right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to San Francisco flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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