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Cheap flights from Knoxville to San Francisco from $144

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Francisco departing on 3/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:51 pm - 12:28 am
TYS
-
SFO
8h 37m
1 stop
Frontier Logo
6:15 am - 7:18 pm
SFO
-
TYS
10h 03m
1 stop
$184Frontier
Fri, Feb 27 - Mon, Mar 2
Frontier Logo
8:13 pm - 10:01 pm
TYS
-
SFO
28h 48m
1 stop
Frontier Logo
6:15 am - 7:27 pm
SFO
-
TYS
10h 12m
1 stop
$245Frontier
Mon, Feb 16 - Fri, Feb 20
Multiple Airlines Logo
7:20 am - 9:39 pm
TYS
-
SFO
17h 19m
2 stops
Multiple Airlines Logo
10:35 pm - 5:34 pm
SFO
-
TYS
15h 59m
1 stop
$282Multiple Airlines
Thu, Mar 5 - Mon, Mar 9
Multiple Airlines Logo
8:54 pm - 5:48 pm
TYS
-
SFO
23h 54m
2 stops
Multiple Airlines Logo
7:32 pm - 7:03 pm
SFO
-
TYS
20h 31m
1 stop
$289Multiple Airlines
Fri, Mar 6 - Tue, Mar 10
Frontier Logo
4:20 pm - 12:23 am
TYS
-
SFO
11h 03m
1 stop
Frontier Logo
9:00 pm - 3:28 pm
SFO
-
TYS
15h 28m
1 stop
$306Frontier
Mon, Apr 6 - Sun, Apr 12
Multiple Airlines Logo
8:00 am - 7:30 pm
TYS
-
SFO
14h 30m
1 stop
Multiple Airlines Logo
10:38 pm - 10:26 pm
SFO
-
TYS
44h 48m
2 stops
$316Multiple Airlines
Thu, Mar 19 - Tue, Mar 24
Multiple Airlines Logo
8:00 am - 8:16 am
TYS
-
SFO
27h 16m
1 stop
Multiple Airlines Logo
5:47 pm - 3:33 pm
SFO
-
TYS
18h 46m
2 stops
$320Multiple Airlines
Sun, Apr 12 - Wed, Apr 15
Delta Logo
2:38 pm - 7:56 pm
TYS
-
SFO
8h 18m
1 stop
Delta Logo
11:35 pm - 9:16 am
SFO
-
TYS
6h 41m
1 stop
$329Delta
Wed, Mar 4 - Mon, Mar 9
Multiple Airlines Logo
4:28 pm - 12:22 am
TYS
-
SFO
10h 54m
1 stop
Multiple Airlines Logo
6:00 am - 3:41 pm
SFO
-
TYS
30h 41m
2 stops
$333Multiple Airlines
Thu, Apr 23 - Sat, Apr 25
Frontier Logo
4:20 pm - 12:23 am
TYS
-
SFO
11h 03m
1 stop
Frontier Logo
5:47 pm - 3:33 pm
SFO
-
TYS
18h 46m
2 stops
$339Frontier
Mon, Apr 13 - Wed, Apr 15

Frontier flights from Knoxville to San Francisco

Our best Frontier deals on Knoxville to San Francisco flight tickets
Frontier
Feb 27
TYS6:51 pmKnoxville McGhee Tyson
8h 37m
1 stop
SFO12:28 amSan Francisco
Mar 2
SFO6:15 amSan Francisco
10h 03m
1 stop
TYS7:18 pmKnoxville McGhee Tyson
$184
Frontier
Feb 23
TYS8:13 pmKnoxville McGhee Tyson
28h 48m
1 stop
SFO10:01 pmSan Francisco
Mar 2
SFO6:15 amSan Francisco
10h 03m
1 stop
TYS7:18 pmKnoxville McGhee Tyson
$186
Frontier
Feb 20
TYS8:12 pmKnoxville McGhee Tyson
14h 51m
1 stop
SFO8:03 amSan Francisco
Feb 23
SFO6:15 amSan Francisco
10h 03m
1 stop
TYS7:18 pmKnoxville McGhee Tyson
$221

Delta flights from Knoxville to San Francisco

Our best Delta deals on Knoxville to San Francisco flight tickets
Delta
Mar 4
TYS2:38 pmKnoxville McGhee Tyson
8h 18m
1 stop
SFO7:56 pmSan Francisco
Mar 9
SFO11:35 pmSan Francisco
6h 41m
1 stop
TYS9:16 amKnoxville McGhee Tyson
$329
Delta
Feb 27
TYS6:41 pmKnoxville McGhee Tyson
8h 08m
1 stop
SFO11:49 pmSan Francisco
Mar 4
SFO12:42 pmSan Francisco
7h 30m
1 stop
TYS11:12 pmKnoxville McGhee Tyson
$369
Delta
Apr 7
TYS11:18 amKnoxville McGhee Tyson
10h 49m
1 stop
SFO7:07 pmSan Francisco
Apr 11
SFO10:40 pmSan Francisco
8h 51m
1 stop
TYS10:31 amKnoxville McGhee Tyson
$383

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 2/27

6:51 pm-12:28 am

1 stop8h 37m

San Francisco

Mon 3/2

6:15 am-7:18 pm

1 stop10h 03m

$184

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 2/16

8:13 pm-10:01 pm

1 stop28h 48m

San Francisco

Fri 2/20

6:15 am-7:27 pm

1 stop10h 12m

$245

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 3/5

7:20 am-9:39 pm

2 stops17h 19m

San Francisco

Mon 3/9

10:35 pm-5:34 pm

1 stop15h 59m

$282

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 3/6

8:54 pm-5:48 pm

2 stops23h 54m

San Francisco

Tue 3/10

7:32 pm-7:03 pm

1 stop20h 31m

$289

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 4/6

4:20 pm-12:23 am

1 stop11h 03m

San Francisco

Sun 4/12

9:00 pm-3:28 pm

1 stop15h 28m

$306

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 3/19

8:00 am-7:30 pm

1 stop14h 30m

San Francisco

Tue 3/24

10:38 pm-10:26 pm

2 stops44h 48m

$316

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sun 4/12

8:00 am-8:16 am

1 stop27h 16m

San Francisco

Wed 4/15

5:47 pm-3:33 pm

2 stops18h 46m

$320

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 3/4

2:38 pm-7:56 pm

1 stop8h 18m

San Francisco

Mon 3/9

11:35 pm-9:16 am

1 stop6h 41m

$329

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 4/23

4:28 pm-12:22 am

1 stop10h 54m

San Francisco

Sat 4/25

6:00 am-3:41 pm

2 stops30h 41m

$333

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 4/13

4:20 pm-12:23 am

1 stop11h 03m

San Francisco

Wed 4/15

5:47 pm-3:33 pm

2 stops18h 46m

$339

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Knoxville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of February, then flying in July is also cheap. Prices for this month can be found on momondo for an average of $376.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $429 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Knoxville for as low as $318 on momondo.

How have Knoxville to San Francisco flight prices changed over time?

As of February 2026, prices for Knoxville to San Francisco flights are approximately 31% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Francisco (TYS to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Francisco

Fastest flight time

7h 55m

Direct flights

None
The fastest flight from Knoxville to San Francisco takes 7h 55m
There are no direct flights from Knoxville to San Francisco. There are no popular flight routes from Knoxville to San Francisco.
Search flight deals

  • How far is Knoxville McGhee Tyson to San Francisco by plane?

    San Francisco is 2114.7 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 7h 55m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Francisco?

Best airlines flying from Knoxville to San Francisco

Compare and see reviews for airlines that fly from Knoxville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $157Free CancellationRating
5.7
3,051 reviews
Search Frontier flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
9,259 reviews
Search United Airlines flights
DeltaPriceFrom $302Free CancellationRating
7.9
8,174 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,258 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Santa Clara
Walnut Creek
Berkeley
Big Sur
Fremont
Half Moon Bay
Daly City
Salinas
Vallejo
Sunnyvale
Livermore
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Francisco?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to San Francisco. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to San Francisco with flexible booking policies on momondo?

Flights from Knoxville to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to San Francisco right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to San Francisco flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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