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Cheap flights from Knoxville to San Francisco from $129

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Francisco departing on 9/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
8:20 am - 2:35 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 15m1 stop Baltimore/Washington
Southwest Logo
6:10 am - 3:30 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
6h 20m1 stop Denver Intl
$247Southwest
Thu, Oct 29 - Tue, Nov 10
Southwest Logo
7:15 am - 1:25 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 10m2 stops Nashville Intl Denver Intl
Southwest Logo
6:10 am - 3:30 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
6h 20m1 stop Denver Intl
$253Southwest
Thu, Oct 29 - Tue, Nov 10
American Airlines Logo
8:02 pm - 12:44 amTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 42m1 stop Dallas/Fort Worth
American Airlines Logo
12:42 pm - 11:18 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 36m1 stop Dallas/Fort Worth
$257American Airlines
Thu, Oct 15 - Wed, Oct 21
American Airlines Logo
5:26 pm - 11:28 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 02m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 4:42 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
8h 12m1 stop Dallas/Fort Worth
$257American Airlines
Thu, Oct 29 - Tue, Nov 10
United Airlines Logo
6:00 am - 10:26 amTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 26m1 stop Chicago O'Hare Intl
United Airlines Logo
10:35 pm - 9:45 amSFO  San Francisco-TYS Knoxville McGhee Tyson
8h 10m1 stop Chicago O'Hare Intl
$257United Airlines
Tue, Sep 22 - Sat, Sep 26
United Airlines Logo
7:20 pm - 12:59 amTYS  Knoxville McGhee Tyson-SFO San Francisco
8h 39m1 stop Washington, D.C. Dulles Intl
United Airlines Logo
11:30 pm - 9:45 amSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 15m1 stop Chicago O'Hare Intl
$257United Airlines
Tue, Sep 22 - Sat, Sep 26
Delta Logo
7:33 am - 2:06 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 33m1 stop Detroit Metropolitan Wayne County
Delta Logo
9:55 pm - 9:29 amSFO  San Francisco-TYS Knoxville McGhee Tyson
8h 34m1 stop Atlanta Hartsfield-Jackson
$257Delta
Wed, Sep 9 - Mon, Sep 21
Delta Logo
5:45 pm - 11:57 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 12m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:30 pm - 11:18 amSFO  San Francisco-TYS Knoxville McGhee Tyson
8h 48m1 stop Atlanta Hartsfield-Jackson
$257Delta
Sat, Sep 12 - Mon, Sep 21
Delta Logo
5:45 pm - 11:57 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 12m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:30 pm - 11:18 amSFO  San Francisco-TYS Knoxville McGhee Tyson
8h 48m1 stop Atlanta Hartsfield-Jackson
$257Delta
Sat, Sep 12 - Sat, Sep 19
Southwest Logo
7:15 am - 1:25 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 10m2 stops Nashville Intl Denver Intl
Southwest Logo
8:00 pm - 12:20 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
13h 20m2 stops Los Angeles Nashville Intl
$264Southwest
Thu, Oct 29 - Tue, Nov 10

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Southwest flights from Knoxville to San Francisco

Our best Southwest deals on Knoxville to San Francisco flight tickets
Southwest
Oct 29
TYS8:20 amKnoxville McGhee Tyson
9h 15m
1 stop
SFO2:35 pmSan Francisco
Nov 10
SFO6:10 amSan Francisco
6h 20m
1 stop
TYS3:30 pmKnoxville McGhee Tyson
$247
Southwest
Oct 29
TYS7:15 amKnoxville McGhee Tyson
9h 10m
2 stops
SFO1:25 pmSan Francisco
Nov 10
SFO6:10 amSan Francisco
6h 20m
1 stop
TYS3:30 pmKnoxville McGhee Tyson
$253
Southwest
Oct 29
TYS7:15 amKnoxville McGhee Tyson
9h 10m
2 stops
SFO1:25 pmSan Francisco
Nov 10
SFO8:00 pmSan Francisco
13h 20m
2 stops
TYS12:20 pmKnoxville McGhee Tyson
$264

Delta flights from Knoxville to San Francisco

Our best Delta deals on Knoxville to San Francisco flight tickets
Delta
Sep 5
TYS5:00 pmKnoxville McGhee Tyson
9h 58m
1 stop
SFO11:58 pmSan Francisco
Sep 22
SFO9:55 pmSan Francisco
8h 34m
1 stop
TYS9:29 amKnoxville McGhee Tyson
$262
Delta
Sep 5
TYS5:00 pmKnoxville McGhee Tyson
9h 58m
1 stop
SFO11:58 pmSan Francisco
Sep 21
SFO9:55 pmSan Francisco
8h 34m
1 stop
TYS9:29 amKnoxville McGhee Tyson
$283
Delta
Sep 11
TYS6:20 pmKnoxville McGhee Tyson
8h 33m
1 stop
SFO11:53 pmSan Francisco
Sep 22
SFO11:30 pmSan Francisco
6h 59m
1 stop
TYS9:29 amKnoxville McGhee Tyson
$291

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Thu 10/29

8:20 am-2:35 pm

1 stop9h 15m

San Francisco

Tue 11/10

6:10 am-3:30 pm

1 stop6h 20m

$247

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Thu 10/29

7:15 am-1:25 pm

2 stops9h 10m

San Francisco

Tue 11/10

6:10 am-3:30 pm

1 stop6h 20m

$253
Quickest round-trip

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Thu 10/15

8:02 pm-12:44 am

1 stop7h 42m

San Francisco

Wed 10/21

12:42 pm-11:18 pm

1 stop7h 36m

$257

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Thu 10/29

5:26 pm-11:28 pm

1 stop9h 02m

San Francisco

Tue 11/10

5:30 am-4:42 pm

1 stop8h 12m

$257

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Tue 9/22

6:00 am-10:26 am

1 stop7h 26m

San Francisco

Sat 9/26

10:35 pm-9:45 am

1 stop8h 10m

$257

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Tue 9/22

7:20 pm-12:59 am

1 stop8h 39m

San Francisco

Sat 9/26

11:30 pm-9:45 am

1 stop7h 15m

$257

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Wed 9/9

7:33 am-2:06 pm

1 stop9h 33m

San Francisco

Mon 9/21

9:55 pm-9:29 am

1 stop8h 34m

$257

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Sat 9/12

5:45 pm-11:57 pm

1 stop9h 12m

San Francisco

Mon 9/21

11:30 pm-11:18 am

1 stop8h 48m

$257

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Sat 9/12

5:45 pm-11:57 pm

1 stop9h 12m

San Francisco

Sat 9/19

11:30 pm-11:18 am

1 stop8h 48m

$257

KnoxvilleSan Francisco

TYS Knoxville McGhee Tyson - SFO San Francisco

TYSSFO

Knoxville McGhee Tyson

Thu 10/29

7:15 am-1:25 pm

2 stops9h 10m

San Francisco

Tue 11/10

8:00 pm-12:20 pm

2 stops13h 20m

$264

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Knoxville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and San Francisco?

Prices are currently low for flights on this route.

Typical prices usually range from $338 to $528.
The lowest price recently found on this route was $247.

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of February, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $429.

How far in advance should I book a flight from Knoxville to San Francisco?

You are more likely to see cheaper flights to San Francisco from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $493 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Knoxville for as low as $292 on momondo.

How have Knoxville to San Francisco flight prices changed over time?

As of August 2026, prices for Knoxville to San Francisco flights are approximately 70% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Francisco (TYS to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Francisco

Fastest flight time

7h 17m

Direct flights

None
The fastest flight from Knoxville to San Francisco takes 7h 17m
There are no direct flights from Knoxville to San Francisco. There are no popular flight routes from Knoxville to San Francisco.
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Frequently asked questions about flying from Knoxville to San Francisco

  • How far is Knoxville McGhee Tyson to San Francisco by plane?

    San Francisco is 2114.2 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 7h 17m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Francisco?

Best airlines flying from Knoxville to San Francisco

Compare and see reviews for airlines that fly from Knoxville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $131Free CancellationRating
5.6
2,694 reviews
Search Frontier flights
American AirlinesPriceFrom $325Free CancellationRating
7.1
11,939 reviews
Search American Airlines flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
10,112 reviews
Search United Airlines flights
DeltaPriceFrom $328Free CancellationRating
7.8
8,509 reviews
Search Delta flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Fremont
Berkeley
Bodega Bay
Hayward
Walnut Creek
Santa Clara
Vallejo
Roseville
Sonoma
Salinas
Sunnyvale
Milpitas
Daly City
Burlingame
Marina
Palo Alto

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Francisco?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to San Francisco. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to San Francisco with flexible booking policies on momondo?

Flights from Knoxville to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to San Francisco right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to San Francisco flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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