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Cheap flights from Knoxville to San Francisco from $141

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Francisco departing on 12/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:53 pm - 9:11 pmTYS-SFO
35h 18m2 stops
Multiple Airlines Logo
6:30 am - 1:11 pmSFO-TYS
27h 41m1 stop
$291Multiple Airlines
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Wed, Dec 3 - Wed, Dec 10
Frontier Logo
7:17 pm - 2:40 pmTYS-SFO
22h 23m1 stop
Frontier Logo
2:54 pm - 3:53 pmSFO-TYS
21h 59m1 stop
$299Frontier
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Thu, Nov 13 - Thu, Nov 20
United Airlines Logo
6:45 am - 11:49 amTYS-SFO
8h 04m1 stop
United Airlines Logo
11:20 pm - 10:49 amSFO-TYS
8h 29m1 stop
$329United Airlines
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Sun, Feb 8 - Sat, Feb 14
American Airlines Logo
12:21 pm - 5:24 pmTYS-SFO
8h 03m1 stop
American Airlines Logo
6:00 am - 5:30 pmSFO-TYS
8h 30m2 stops
$334American Airlines
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Sun, Feb 8 - Sat, Feb 14
American Airlines Logo
4:41 pm - 11:12 pmTYS-SFO
9h 31m1 stop
American Airlines Logo
12:50 am - 11:29 amSFO-TYS
7h 39m1 stop
$351American Airlines
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Sun, Feb 8 - Fri, Feb 13
United Airlines Logo
5:45 am - 11:29 amTYS-SFO
8h 44m1 stop
United Airlines Logo
6:30 am - 3:51 pmSFO-TYS
6h 21m1 stop
$369United Airlines
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Sun, Nov 23 - Fri, Nov 28
Delta Logo
6:00 pm - 12:20 amTYS-SFO
9h 20m1 stop
Delta Logo
8:15 am - 8:05 pmSFO-TYS
8h 50m1 stop
$374Delta
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Wed, Dec 3 - Wed, Dec 10
Southwest Logo
7:50 am - 8:00 pmTYS-SFO
15h 10m2 stops
Southwest Logo
10:55 pm - 12:45 pmSFO-TYS
10h 50m1 stop
$389Southwest
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Wed, Mar 11 - Wed, Mar 18
Southwest Logo
6:35 am - 12:35 pmTYS-SFO
9h 00m2 stops
Southwest Logo
10:55 pm - 11:40 amSFO-TYS
9h 45m1 stop
$489Southwest
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Thu, Apr 23 - Sun, Apr 26
Delta Logo
7:39 am - 2:15 pmTYS-SFO
9h 36m1 stop
Delta Logo
10:30 pm - 9:37 amSFO-TYS
8h 07m1 stop
$688Delta
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Mon, Nov 24 - Sun, Nov 30

Delta flights from Knoxville to San Francisco

Our best Delta deals on Knoxville to San Francisco flight tickets
Delta
Dec 3
TYS6:00 pmKnoxville McGhee Tyson
9h 20m
1 stop
SFO12:20 amSan Francisco
Dec 10
SFO8:15 amSan Francisco
8h 50m
1 stop
TYS8:05 pmKnoxville McGhee Tyson
$374
Find similar
Delta
Nov 24
TYS7:39 amKnoxville McGhee Tyson
9h 36m
1 stop
SFO2:15 pmSan Francisco
Nov 30
SFO10:30 pmSan Francisco
8h 07m
1 stop
TYS9:37 amKnoxville McGhee Tyson
$688
Find similar
Delta
Nov 15
TYS12:49 pmKnoxville McGhee Tyson
8h 12m
1 stop
SFO6:01 pmSan Francisco
Nov 18
SFO12:30 amSan Francisco
10h 14m
2 stops
TYS1:44 pmKnoxville McGhee Tyson
$1,247
Find similar

Southwest flights from Knoxville to San Francisco

Our best Southwest deals on Knoxville to San Francisco flight tickets
Southwest
Mar 11
TYS7:50 amKnoxville McGhee Tyson
15h 10m
2 stops
SFO8:00 pmSan Francisco
Mar 18
SFO10:55 pmSan Francisco
10h 50m
1 stop
TYS12:45 pmKnoxville McGhee Tyson
$389
Find similar
Southwest
Apr 23
TYS6:35 amKnoxville McGhee Tyson
9h 00m
2 stops
SFO12:35 pmSan Francisco
Apr 26
SFO10:55 pmSan Francisco
9h 45m
1 stop
TYS11:40 amKnoxville McGhee Tyson
$489
Find similar
Southwest
Apr 23
TYS2:45 pmKnoxville McGhee Tyson
10h 35m
2 stops
SFO10:20 pmSan Francisco
Apr 26
SFO5:25 amSan Francisco
12h 40m
2 stops
TYS9:05 pmKnoxville McGhee Tyson
$508
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 12/3

12:53 pm-9:11 pm

2 stops35h 18m

San Francisco

Wed 12/10

6:30 am-1:11 pm

1 stop27h 41m

$291

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 11/13

7:17 pm-2:40 pm

1 stop22h 23m

San Francisco

Thu 11/20

2:54 pm-3:53 pm

1 stop21h 59m

$299

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sun 2/8

6:45 am-11:49 am

1 stop8h 04m

San Francisco

Sat 2/14

11:20 pm-10:49 am

1 stop8h 29m

$329

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sun 2/8

12:21 pm-5:24 pm

1 stop8h 03m

San Francisco

Sat 2/14

6:00 am-5:30 pm

2 stops8h 30m

$334

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sun 2/8

4:41 pm-11:12 pm

1 stop9h 31m

San Francisco

Fri 2/13

12:50 am-11:29 am

1 stop7h 39m

$351

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sun 11/23

5:45 am-11:29 am

1 stop8h 44m

San Francisco

Fri 11/28

6:30 am-3:51 pm

1 stop6h 21m

$369

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 12/3

6:00 pm-12:20 am

1 stop9h 20m

San Francisco

Wed 12/10

8:15 am-8:05 pm

1 stop8h 50m

$374

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 3/11

7:50 am-8:00 pm

2 stops15h 10m

San Francisco

Wed 3/18

10:55 pm-12:45 pm

1 stop10h 50m

$389

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 4/23

6:35 am-12:35 pm

2 stops9h 00m

San Francisco

Sun 4/26

10:55 pm-11:40 am

1 stop9h 45m

$489

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 11/24

7:39 am-2:15 pm

1 stop9h 36m

San Francisco

Sun 11/30

10:30 pm-9:37 am

1 stop8h 07m

$688

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Knoxville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of January, then flying in July is also cheap. Prices for this month can be found on momondo for an average of $381.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Knoxville to San Francisco is on a Tuesday when prices can be found for as low as $408. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $555.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Knoxville to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $360. Flights in the morning are often more expensive with an average ticket price of $508.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $436 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Knoxville for as low as $347 on momondo.

How have Knoxville to San Francisco flight prices changed over time?

As of November 2025, prices for Knoxville to San Francisco flights are approximately 31% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Francisco (TYS to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Francisco

Direct flights

None
There are no direct flights from Knoxville to San Francisco. There are no popular flight routes from Knoxville to San Francisco.
Search flight deals

  • How far is Knoxville McGhee Tyson to San Francisco by plane?

    San Francisco is 2114.7 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 7h 43m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Francisco?

Best airlines flying from Knoxville to San Francisco

Compare and see reviews for airlines that fly from Knoxville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $157Free CancellationRating
5.8
3,117 reviews
Search Frontier flights
United AirlinesPriceFrom $243Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights
DeltaPriceFrom $308Free CancellationRating
7.9
8,002 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Calistoga
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Vallejo
Walnut Creek
Half Moon Bay
Salinas
Turlock
Livermore
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Francisco?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to San Francisco. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to San Francisco with flexible booking policies on momondo?

Flights from Knoxville to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to San Francisco right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to San Francisco flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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