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Cheap flights from Knoxville to San Francisco from $182

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Francisco departing on 1/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
4:23 pm - 8:03 am
TYS
-
SFO
18h 40m1 stop
Frontier Logo
6:15 am - 7:23 pm
SFO
-
TYS
10h 08m1 stop
$182Frontier
Thu, Jan 8 - Thu, Jan 15
United Airlines Logo
4:25 pm - 9:35 pm
TYS
-
SFO
8h 10m1 stop
United Airlines Logo
11:56 pm - 10:32 am
SFO
-
TYS
7h 36m1 stop
$277United Airlines
Wed, Jan 21 - Wed, Jan 28
American Airlines Logo
12:21 pm - 8:10 pm
TYS
-
SFO
10h 49m2 stops
American Airlines Logo
6:00 am - 5:42 pm
SFO
-
TYS
8h 42m1 stop
$282American Airlines
Wed, Jan 21 - Wed, Jan 28
Multiple Airlines Logo
8:18 pm - 11:00 am
TYS
-
SFO
17h 42m1 stop
Multiple Airlines Logo
4:46 pm - 6:39 pm
SFO
-
TYS
22h 53m2 stops
$311Multiple Airlines
Thu, Jan 15 - Sat, Jan 24
United Airlines Logo
7:20 pm - 1:30 am
TYS
-
SFO
9h 10m1 stop
United Airlines Logo
11:20 pm - 10:57 am
SFO
-
TYS
8h 37m1 stop
$329United Airlines
Thu, Jan 15 - Mon, Jan 19
Multiple Airlines Logo
10:00 am - 5:54 pm
TYS
-
SFO
10h 54m1 stop
Multiple Airlines Logo
8:42 pm - 6:10 pm
SFO
-
TYS
42h 28m2 stops
$330Multiple Airlines
Thu, Feb 5 - Mon, Feb 9
Frontier Logo
4:23 pm - 9:46 am
TYS
-
SFO
20h 23m2 stops
Frontier Logo
6:15 am - 7:23 pm
SFO
-
TYS
10h 08m1 stop
$332Frontier
Thu, Jan 8 - Thu, Jan 15
Multiple Airlines Logo
12:55 pm - 1:24 pm
TYS
-
SFO
27h 29m2 stops
Multiple Airlines Logo
6:15 am - 3:30 pm
SFO
-
TYS
30h 15m1 stop
$334Multiple Airlines
Mon, Jan 12 - Thu, Jan 22
Multiple Airlines Logo
8:18 pm - 11:00 am
TYS
-
SFO
17h 42m1 stop
Multiple Airlines Logo
9:11 pm - 3:57 pm
SFO
-
TYS
39h 46m2 stops
$335Multiple Airlines
Thu, Jan 15 - Mon, Jan 19
Multiple Airlines Logo
8:18 pm - 11:00 am
TYS
-
SFO
17h 42m1 stop
Multiple Airlines Logo
9:11 pm - 3:57 pm
SFO
-
TYS
39h 46m2 stops
$340Multiple Airlines
Thu, Jan 15 - Mon, Jan 19

American Airlines flights from Knoxville to San Francisco

Our best American Airlines deals on Knoxville to San Francisco flight tickets
American Airlines
Jan 21
TYS12:21 pmKnoxville McGhee Tyson
10h 49m
2 stops
SFO8:10 pmSan Francisco
Jan 28
SFO6:00 amSan Francisco
8h 42m
1 stop
TYS5:42 pmKnoxville McGhee Tyson
$282
Find similar
American Airlines
Jan 21
TYS12:17 pmKnoxville McGhee Tyson
10h 02m
2 stops
SFO7:19 pmSan Francisco
Jan 28
SFO6:00 amSan Francisco
8h 42m
2 stops
TYS5:42 pmKnoxville McGhee Tyson
$396
Find similar
American Airlines
Jan 6
TYS6:00 amKnoxville McGhee Tyson
8h 01m
1 stop
SFO11:01 amSan Francisco
Jan 10
SFO6:00 amSan Francisco
6h 46m
1 stop
TYS3:46 pmKnoxville McGhee Tyson
$409
Find similar

United Airlines flights from Knoxville to San Francisco

Our best United Airlines deals on Knoxville to San Francisco flight tickets
United Airlines
Jan 21
TYS4:25 pmKnoxville McGhee Tyson
8h 10m
1 stop
SFO9:35 pmSan Francisco
Jan 28
SFO11:56 pmSan Francisco
7h 36m
1 stop
TYS10:32 amKnoxville McGhee Tyson
$277
Find similar
United Airlines
Jan 15
TYS7:20 pmKnoxville McGhee Tyson
9h 10m
1 stop
SFO1:30 amSan Francisco
Jan 19
SFO11:20 pmSan Francisco
8h 37m
1 stop
TYS10:57 amKnoxville McGhee Tyson
$329
Find similar
United Airlines
Jan 8
TYS8:45 amKnoxville McGhee Tyson
7h 44m
1 stop
SFO1:29 pmSan Francisco
Jan 12
SFO11:20 pmSan Francisco
8h 37m
1 stop
TYS10:57 amKnoxville McGhee Tyson
$369
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 1/8

4:23 pm-8:03 am

1 stop18h 40m

San Francisco

Thu 1/15

6:15 am-7:23 pm

1 stop10h 08m

$182

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 1/21

4:25 pm-9:35 pm

1 stop8h 10m

San Francisco

Wed 1/28

11:56 pm-10:32 am

1 stop7h 36m

$277

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 1/21

12:21 pm-8:10 pm

2 stops10h 49m

San Francisco

Wed 1/28

6:00 am-5:42 pm

1 stop8h 42m

$282

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 1/15

8:18 pm-11:00 am

1 stop17h 42m

San Francisco

Sat 1/24

4:46 pm-6:39 pm

2 stops22h 53m

$311

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 1/15

7:20 pm-1:30 am

1 stop9h 10m

San Francisco

Mon 1/19

11:20 pm-10:57 am

1 stop8h 37m

$329

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 2/5

10:00 am-5:54 pm

1 stop10h 54m

San Francisco

Mon 2/9

8:42 pm-6:10 pm

2 stops42h 28m

$330

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 1/8

4:23 pm-9:46 am

2 stops20h 23m

San Francisco

Thu 1/15

6:15 am-7:23 pm

1 stop10h 08m

$332

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 1/12

12:55 pm-1:24 pm

2 stops27h 29m

San Francisco

Thu 1/22

6:15 am-3:30 pm

1 stop30h 15m

$334

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 1/15

8:18 pm-11:00 am

1 stop17h 42m

San Francisco

Mon 1/19

9:11 pm-3:57 pm

2 stops39h 46m

$335

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 1/15

8:18 pm-11:00 am

1 stop17h 42m

San Francisco

Mon 1/19

9:11 pm-3:57 pm

2 stops39h 46m

$340

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Knoxville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of July, then flying in February is also cheap. Prices for this month can be found on momondo for an average of $385.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Knoxville to San Francisco is on a Tuesday when prices can be found for as low as $408. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $555.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Knoxville to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $360. Flights in the morning are often more expensive with an average ticket price of $508.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $434 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Knoxville for as low as $361 on momondo.

How have Knoxville to San Francisco flight prices changed over time?

As of December 2025, prices for Knoxville to San Francisco flights are approximately 12% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Francisco (TYS to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Francisco

Fastest flight time

7h 55m

Direct flights

None
The fastest flight from Knoxville to San Francisco takes 7h 55m
There are no direct flights from Knoxville to San Francisco. There are no popular flight routes from Knoxville to San Francisco.
Search flight deals

  • How far is Knoxville McGhee Tyson to San Francisco by plane?

    San Francisco is 2114.7 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 7h 55m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Francisco?

Best airlines flying from Knoxville to San Francisco

Compare and see reviews for airlines that fly from Knoxville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $180Free CancellationRating
5.8
3,075 reviews
Search Frontier flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
9,106 reviews
Search United Airlines flights
DeltaPriceFrom $308Free CancellationRating
7.9
8,014 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Berkeley
Santa Clara
Walnut Creek
Fremont
Daly City
Half Moon Bay
Vallejo
Salinas
Livermore
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Francisco?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to San Francisco. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to San Francisco with flexible booking policies on momondo?

Flights from Knoxville to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to San Francisco right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to San Francisco flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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