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Cheap flights from Knoxville to San Francisco from $122

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Francisco departing on 8/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:19 pm - 3:46 pm
TYS
-
SFO
22h 27m
1 stop
Frontier Logo
6:00 am - 7:24 pm
SFO
-
TYS
10h 24m
1 stop
$244Frontier
Wed, Aug 5 - Wed, Aug 12
Frontier Logo
8:19 pm - 12:23 am
TYS
-
SFO
7h 04m
1 stop
Frontier Logo
6:00 am - 7:24 pm
SFO
-
TYS
10h 24m
1 stop
$269Frontier
Mon, Jul 27 - Wed, Aug 5
Frontier Logo
8:19 pm - 11:38 am
TYS
-
SFO
18h 19m
1 stop
Frontier Logo
5:30 pm - 7:24 pm
SFO
-
TYS
22h 54m
1 stop
$270Frontier
Mon, Aug 10 - Thu, Aug 13
Frontier Logo
8:19 pm - 12:18 am
TYS
-
SFO
6h 59m
1 stop
Frontier Logo
6:00 am - 7:24 pm
SFO
-
TYS
10h 24m
1 stop
$271Frontier
Fri, Aug 7 - Wed, Aug 12
Frontier Logo
8:19 pm - 12:23 am
TYS
-
SFO
7h 04m
1 stop
Frontier Logo
12:38 pm - 7:24 pm
SFO
-
TYS
27h 46m
1 stop
$281Frontier
Fri, Jul 31 - Tue, Aug 4
Frontier Logo
8:19 pm - 12:23 am
TYS
-
SFO
7h 04m
1 stop
Frontier Logo
9:39 pm - 7:24 pm
SFO
-
TYS
18h 45m
1 stop
$308Frontier
Fri, Jul 24 - Sun, Jul 26
Frontier Logo
8:19 pm - 12:23 am
TYS
-
SFO
7h 04m
1 stop
Frontier Logo
6:00 am - 7:24 pm
SFO
-
TYS
10h 24m
1 stop
$309Frontier
Wed, Jul 15 - Wed, Jul 22
Multiple Airlines Logo
2:47 pm - 10:30 am
TYS
-
SFO
22h 43m
1 stop
Multiple Airlines Logo
10:23 pm - 1:57 pm
SFO
-
TYS
36h 34m
2 stops
$332Multiple Airlines
Mon, Jul 27 - Wed, Aug 5
Multiple Airlines Logo
5:54 pm - 7:56 pm
TYS
-
SFO
29h 02m
2 stops
Multiple Airlines Logo
7:30 pm - 1:49 pm
SFO
-
TYS
15h 19m
1 stop
$333Multiple Airlines
Mon, Aug 17 - Sat, Aug 22
Multiple Airlines Logo
12:53 pm - 7:18 pm
TYS
-
SFO
33h 25m
2 stops
Multiple Airlines Logo
7:08 pm - 10:56 pm
SFO
-
TYS
24h 48m
1 stop
$342Multiple Airlines
Mon, Jul 27 - Sat, Aug 1

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Delta flights from Knoxville to San Francisco

Our best Delta deals on Knoxville to San Francisco flight tickets
Delta
Sep 15
TYS5:28 pmKnoxville McGhee Tyson
7h 21m
1 stop
SFO9:49 pmSan Francisco
Sep 22
SFO6:00 amSan Francisco
8h 28m
1 stop
TYS5:28 pmKnoxville McGhee Tyson
$355
Delta
Nov 24
TYS7:20 pmKnoxville McGhee Tyson
7h 55m
1 stop
SFO12:15 amSan Francisco
Dec 1
SFO10:45 pmSan Francisco
8h 29m
1 stop
TYS10:14 amKnoxville McGhee Tyson
$369
Delta
Aug 28
TYS6:25 pmKnoxville McGhee Tyson
8h 22m
1 stop
SFO11:47 pmSan Francisco
Sep 5
SFO10:00 pmSan Francisco
8h 44m
1 stop
TYS9:44 amKnoxville McGhee Tyson
$406

Frontier flights from Knoxville to San Francisco

Our best Frontier deals on Knoxville to San Francisco flight tickets
Frontier
Aug 5
TYS8:19 pmKnoxville McGhee Tyson
22h 27m
1 stop
SFO3:46 pmSan Francisco
Aug 12
SFO6:00 amSan Francisco
10h 24m
1 stop
TYS7:24 pmKnoxville McGhee Tyson
$244
Frontier
Jul 27
TYS8:19 pmKnoxville McGhee Tyson
7h 04m
1 stop
SFO12:23 amSan Francisco
Aug 5
SFO6:00 amSan Francisco
10h 24m
1 stop
TYS7:24 pmKnoxville McGhee Tyson
$269
Frontier
Aug 10
TYS8:19 pmKnoxville McGhee Tyson
18h 19m
1 stop
SFO11:38 amSan Francisco
Aug 13
SFO5:30 pmSan Francisco
22h 54m
1 stop
TYS7:24 pmKnoxville McGhee Tyson
$270

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 28, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 8/5

8:19 pm-3:46 pm

1 stop22h 27m

San Francisco

Wed 8/12

6:00 am-7:24 pm

1 stop10h 24m

$244

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 7/27

8:19 pm-12:23 am

1 stop7h 04m

San Francisco

Wed 8/5

6:00 am-7:24 pm

1 stop10h 24m

$269

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 8/10

8:19 pm-11:38 am

1 stop18h 19m

San Francisco

Thu 8/13

5:30 pm-7:24 pm

1 stop22h 54m

$270
Quickest round-trip

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 8/7

8:19 pm-12:18 am

1 stop6h 59m

San Francisco

Wed 8/12

6:00 am-7:24 pm

1 stop10h 24m

$271

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 7/31

8:19 pm-12:23 am

1 stop7h 04m

San Francisco

Tue 8/4

12:38 pm-7:24 pm

1 stop27h 46m

$281

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 7/24

8:19 pm-12:23 am

1 stop7h 04m

San Francisco

Sun 7/26

9:39 pm-7:24 pm

1 stop18h 45m

$308

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 7/15

8:19 pm-12:23 am

1 stop7h 04m

San Francisco

Wed 7/22

6:00 am-7:24 pm

1 stop10h 24m

$309

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 7/27

2:47 pm-10:30 am

1 stop22h 43m

San Francisco

Wed 8/5

10:23 pm-1:57 pm

2 stops36h 34m

$332

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 8/17

5:54 pm-7:56 pm

2 stops29h 02m

San Francisco

Sat 8/22

7:30 pm-1:49 pm

1 stop15h 19m

$333

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 7/27

12:53 pm-7:18 pm

2 stops33h 25m

San Francisco

Sat 8/1

7:08 pm-10:56 pm

1 stop24h 48m

$342

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of February, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $408.

How far in advance should I book a flight from Knoxville to San Francisco?

You are more likely to see cheaper flights to San Francisco from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $475 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Knoxville for as low as $292 on momondo.

How have Knoxville to San Francisco flight prices changed over time?

As of June 2026, prices for Knoxville to San Francisco flights are approximately 128% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Francisco (TYS to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Francisco

Fastest flight time

7h 04m

Direct flights

None
The fastest flight from Knoxville to San Francisco takes 7h 04m
There are no direct flights from Knoxville to San Francisco. There are no popular flight routes from Knoxville to San Francisco.
Search flight deals

Frequently asked questions about flying from Knoxville to San Francisco

  • How far is Knoxville McGhee Tyson to San Francisco by plane?

    San Francisco is 2114.2 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 7h 04m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Francisco?

Best airlines flying from Knoxville to San Francisco

Compare and see reviews for airlines that fly from Knoxville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $157Free CancellationRating
5.6
2,856 reviews
Search Frontier flights
DeltaPriceFrom $308Free CancellationRating
7.8
8,454 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.1
11,771 reviews
Search American Airlines flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
9,895 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Bodega Bay
South San Francisco
Sonoma
Fremont
Hayward
Roseville
Walnut Creek
Santa Clara
Berkeley
Vallejo
Salinas
Sunnyvale
Big Sur
Burlingame
Daly City
Milpitas
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Francisco?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to San Francisco. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to San Francisco with flexible booking policies on momondo?

Flights from Knoxville to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to San Francisco right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to San Francisco flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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