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Cheap flights from Knoxville to San Francisco from $122

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to San Francisco departing on 6/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
4:28 pm - 12:27 am
TYS
-
SFO
10h 59m
1 stop
Frontier Logo
6:00 am - 3:33 pm
SFO
-
TYS
6h 33m
1 stop
$185Frontier
Thu, Apr 30 - Sun, May 3
Frontier Logo
8:32 pm - 11:42 am
TYS
-
SFO
18h 10m
1 stop
Frontier Logo
6:00 am - 7:37 pm
SFO
-
TYS
10h 37m
1 stop
$226Frontier
Mon, Jun 1 - Wed, Jun 10
Frontier Logo
4:20 pm - 12:28 am
TYS
-
SFO
11h 08m
1 stop
Frontier Logo
6:00 am - 3:28 pm
SFO
-
TYS
6h 28m
1 stop
$235Frontier
Mon, Apr 6 - Fri, Apr 10
American Airlines Logo
6:54 pm - 11:09 pm
TYS
-
SFO
7h 15m
1 stop
American Airlines Logo
9:08 am - 10:12 pm
SFO
-
TYS
10h 04m
1 stop
$253American Airlines
Tue, May 5 - Tue, May 12
Frontier Logo
8:32 pm - 11:42 am
TYS
-
SFO
18h 10m
1 stop
Frontier Logo
8:56 am - 7:33 pm
SFO
-
TYS
7h 37m
1 stop
$261Frontier
Fri, May 22 - Mon, May 25
United Airlines Logo
7:05 am - 12:18 pm
TYS
-
SFO
8h 13m
1 stop
United Airlines Logo
5:00 am - 3:07 pm
SFO
-
TYS
7h 07m
1 stop
$278United Airlines
Tue, Apr 28 - Sat, May 2
Multiple Airlines Logo
8:00 am - 5:51 pm
TYS
-
SFO
12h 51m
1 stop
Multiple Airlines Logo
10:38 pm - 10:24 pm
SFO
-
TYS
20h 46m
2 stops
$288Multiple Airlines
Thu, Apr 30 - Sun, May 3
Multiple Airlines Logo
8:00 am - 5:51 pm
TYS
-
SFO
12h 51m
1 stop
Multiple Airlines Logo
11:26 pm - 10:36 am
SFO
-
TYS
32h 10m
2 stops
$290Multiple Airlines
Thu, Apr 30 - Mon, May 4
United Airlines Logo
7:00 am - 11:24 am
TYS
-
SFO
7h 24m
1 stop
United Airlines Logo
5:30 am - 4:54 pm
SFO
-
TYS
8h 24m
1 stop
$298United Airlines
Sat, May 2 - Sat, May 9
Frontier Logo
8:32 pm - 11:42 am
TYS
-
SFO
18h 10m
1 stop
Frontier Logo
6:00 am - 7:33 pm
SFO
-
TYS
10h 33m
1 stop
$301Frontier
Fri, May 8 - Mon, May 11

Southwest flights from Knoxville to San Francisco

Our best Southwest deals on Knoxville to San Francisco flight tickets
Southwest
May 2
TYS12:20 pmKnoxville McGhee Tyson
12h 00m
2 stops
SFO9:20 pmSan Francisco
May 9
SFO10:10 amSan Francisco
6h 25m
1 stop
TYS7:35 pmKnoxville McGhee Tyson
$308
Southwest
May 6
TYS7:05 amKnoxville McGhee Tyson
11h 15m
2 stops
SFO3:20 pmSan Francisco
May 12
SFO5:25 amSan Francisco
11h 15m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
$332
Southwest
May 2
TYS12:20 pmKnoxville McGhee Tyson
12h 00m
2 stops
SFO9:20 pmSan Francisco
May 9
SFO10:10 amSan Francisco
6h 25m
1 stop
TYS7:35 pmKnoxville McGhee Tyson
$351

American Airlines flights from Knoxville to San Francisco

Our best American Airlines deals on Knoxville to San Francisco flight tickets
American Airlines
May 5
TYS6:54 pmKnoxville McGhee Tyson
7h 15m
1 stop
SFO11:09 pmSan Francisco
May 12
SFO9:08 amSan Francisco
10h 04m
1 stop
TYS10:12 pmKnoxville McGhee Tyson
$253
American Airlines
May 9
TYS6:54 pmKnoxville McGhee Tyson
7h 15m
1 stop
SFO11:09 pmSan Francisco
May 16
SFO2:10 pmSan Francisco
6h 46m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
$304
American Airlines
May 14
TYS6:54 pmKnoxville McGhee Tyson
8h 00m
1 stop
SFO11:54 pmSan Francisco
May 18
SFO11:59 pmSan Francisco
9h 31m
1 stop
TYS12:30 pmKnoxville McGhee Tyson
$329

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 27, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 4/30

4:28 pm-12:27 am

1 stop10h 59m

San Francisco

Sun 5/3

6:00 am-3:33 pm

1 stop6h 33m

$185

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 6/1

8:32 pm-11:42 am

1 stop18h 10m

San Francisco

Wed 6/10

6:00 am-7:37 pm

1 stop10h 37m

$226

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 4/6

4:20 pm-12:28 am

1 stop11h 08m

San Francisco

Fri 4/10

6:00 am-3:28 pm

1 stop6h 28m

$235

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Tue 5/5

6:54 pm-11:09 pm

1 stop7h 15m

San Francisco

Tue 5/12

9:08 am-10:12 pm

1 stop10h 04m

$253

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 5/22

8:32 pm-11:42 am

1 stop18h 10m

San Francisco

Mon 5/25

8:56 am-7:33 pm

1 stop7h 37m

$261
Quickest round-trip

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Tue 4/28

7:05 am-12:18 pm

1 stop8h 13m

San Francisco

Sat 5/2

5:00 am-3:07 pm

1 stop7h 07m

$278

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 4/30

8:00 am-5:51 pm

1 stop12h 51m

San Francisco

Sun 5/3

10:38 pm-10:24 pm

2 stops20h 46m

$288

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 4/30

8:00 am-5:51 pm

1 stop12h 51m

San Francisco

Mon 5/4

11:26 pm-10:36 am

2 stops32h 10m

$290

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sat 5/2

7:00 am-11:24 am

1 stop7h 24m

San Francisco

Sat 5/9

5:30 am-4:54 pm

1 stop8h 24m

$298

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 5/8

8:32 pm-11:42 am

1 stop18h 10m

San Francisco

Mon 5/11

6:00 am-7:33 pm

1 stop10h 33m

$301

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Knoxville to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of February, then flying in July is also cheap. Prices for this month can be found on momondo for an average of $381.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $430 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Knoxville for as low as $307 on momondo.

How have Knoxville to San Francisco flight prices changed over time?

As of March 2026, prices for Knoxville to San Francisco flights are approximately 27% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to San Francisco (TYS to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to San Francisco

Fastest flight time

7h 24m

Direct flights

None
The fastest flight from Knoxville to San Francisco takes 7h 24m
There are no direct flights from Knoxville to San Francisco. There are no popular flight routes from Knoxville to San Francisco.
Search flight deals

  • How far is Knoxville McGhee Tyson to San Francisco by plane?

    San Francisco is 2114.2 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 7h 24m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to San Francisco Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The required travel and health documents for your San Francisco Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Francisco Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to San Francisco?

Best airlines flying from Knoxville to San Francisco

Compare and see reviews for airlines that fly from Knoxville to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $184Free CancellationRating
5.7
3,013 reviews
Search Frontier flights
DeltaPriceFrom $276Free CancellationRating
7.9
8,357 reviews
Search Delta flights
United AirlinesPriceFrom $308Free CancellationRating
7.4
9,499 reviews
Search United Airlines flights
American AirlinesPriceFrom $308Free CancellationRating
7.1
11,520 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Roseville
Hayward
Berkeley
Santa Clara
Big Sur
Fremont
Calistoga
Vallejo
Salinas
Daly City
Half Moon Bay
Milpitas
South San Francisco
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to San Francisco?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to San Francisco. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to San Francisco with flexible booking policies on momondo?

Flights from Knoxville to San Francisco with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to San Francisco right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to San Francisco flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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