Cheap flights from Fort Myers to San Francisco from $161

If you aren’t able to travel to San Francisco during the month of September, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $378.

The cheapest day to depart from Fort Myers to San Francisco is on a Saturday when prices can be found for as low as $389. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $1,608.

Our data shows that the cheapest Fort Myers to San Francisco flights are usually those with departure times in the afternoon. Our users have found flights to San Francisco in the afternoon for as low as $448. Flights in the morning are often more expensive with an average ticket price of $543.

Fly from Fort Myers SW Florida Intl to San Francisco for the best Fort Myers SW Florida Intl - San Francisco flight prices

You are more likely to see cheaper flights to San Francisco from Fort Myers when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $418 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Fort Myers for as low as $350 on momondo.

There are 4 cabin classes available to choose from on Fort Myers to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 2% on your flight if you consider stops on a Fort Myers to San Francisco flight.

As of September 2026, prices for Fort Myers to San Francisco flights are approximately 30% more expensive when compared to flights at the same time last year.

Alaska Airlines and Southwest are the most popular carriers operating from Fort Myers SW Florida Intl to San Francisco

United Airlines, Delta and American Airlines are the top three most popular airlines that fly to San Francisco from Fort Myers according to our data. United Airlines is the first choice among our users, with 31% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 5 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

Charlotte (CLT) was the most common stop: 63% of momondo users choosing 1-stop flights on this route connected there.

Flights via Denver (DEN) offer the lowest average round-trip price of $322.

Flights connecting via St. Louis (STL) have the shortest average one-way travel time: 8h 10m.

St. Louis (STL) has the shortest average layover time for this route: 1h 00m.