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Cheap flights from Florence, South Carolina to San Antonio from $479

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to San Antonio departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:33 pm - 8:05 pmFLO-SAT
6h 32m1 stop
American Airlines Logo
6:06 pm - 11:41 pmSAT-FLO
4h 35m1 stop
$479American Airlines
Find Deal
Wed, Apr 15 - Sat, Apr 18
American Airlines Logo
5:13 am - 10:53 amFLO-SAT
6h 40m1 stop
American Airlines Logo
2:39 pm - 11:41 pmSAT-FLO
8h 02m2 stops
$484American Airlines
Find Deal
Wed, Apr 15 - Sat, Apr 18
American Airlines Logo
2:33 pm - 11:38 pmFLO-SAT
10h 05m2 stops
American Airlines Logo
2:39 pm - 11:41 pmSAT-FLO
8h 02m2 stops
$489American Airlines
Find Deal
Wed, Apr 15 - Sat, Apr 18
American Airlines Logo
11:11 am - 4:45 pmFLO-SAT
6h 34m1 stop
American Airlines Logo
6:00 am - 5:09 pmSAT-FLO
10h 09m2 stops
$518American Airlines
Find Deal
Thu, Nov 6 - Mon, Nov 10
American Airlines Logo
5:15 am - 2:10 pmFLO-SAT
9h 55m2 stops
American Airlines Logo
12:55 pm - 10:53 pmSAT-FLO
8h 58m2 stops
$523American Airlines
Find Deal
Thu, Nov 6 - Mon, Nov 10
American Airlines Logo
11:11 am - 4:45 pmFLO-SAT
6h 34m1 stop
American Airlines Logo
7:21 am - 5:09 pmSAT-FLO
8h 48m1 stop
$858American Airlines
Find Deal
Thu, Nov 6 - Mon, Nov 10

American Airlines flights from Florence, South Carolina to San Antonio

Our best American Airlines deals on Florence, South Carolina to San Antonio flight tickets
American Airlines
Apr 15
FLO2:33 pmFlorence
6h 32m
1 stop
SAT8:05 pmSan Antonio
Apr 18
SAT6:06 pmSan Antonio
4h 35m
1 stop
FLO11:41 pmFlorence
$479
Find similar
American Airlines
Apr 15
FLO5:13 amFlorence
6h 40m
1 stop
SAT10:53 amSan Antonio
Apr 18
SAT2:39 pmSan Antonio
8h 02m
2 stops
FLO11:41 pmFlorence
$484
Find similar
American Airlines
Apr 15
FLO2:33 pmFlorence
10h 05m
2 stops
SAT11:38 pmSan Antonio
Apr 18
SAT2:39 pmSan Antonio
8h 02m
2 stops
FLO11:41 pmFlorence
$489
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from Florence, South Carolina to San Antonio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Wed 4/15

2:33 pm-8:05 pm

1 stop6h 32m

San Antonio

Sat 4/18

6:06 pm-11:41 pm

1 stop4h 35m

$479

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Wed 4/15

5:13 am-10:53 am

1 stop6h 40m

San Antonio

Sat 4/18

2:39 pm-11:41 pm

2 stops8h 02m

$484

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Wed 4/15

2:33 pm-11:38 pm

2 stops10h 05m

San Antonio

Sat 4/18

2:39 pm-11:41 pm

2 stops8h 02m

$489

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Thu 11/6

11:11 am-4:45 pm

1 stop6h 34m

San Antonio

Mon 11/10

6:00 am-5:09 pm

2 stops10h 09m

$518

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Thu 11/6

5:15 am-2:10 pm

2 stops9h 55m

San Antonio

Mon 11/10

12:55 pm-10:53 pm

2 stops8h 58m

$523

FlorenceSan Antonio

FLO - SAT

FLOSAT

Florence

Thu 11/6

11:11 am-4:45 pm

1 stop6h 34m

San Antonio

Mon 11/10

7:21 am-5:09 pm

1 stop8h 48m

$858

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to San Antonio from

How to get the cheapest flight ticket from Florence, South Carolina to San Antonio

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to San Antonio?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to San Antonio from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 66% of people opting to fly with this airline when traveling to San Antonio. Keep in mind that there are 6 different airlines that fly to San Antonio on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to San Antonio

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to San Antonio according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to San Antonio (FLO to SAT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to San Antonio

Direct flights

None
There are no direct flights from Florence, South Carolina to San Antonio. There are no popular flight routes from Florence, South Carolina to San Antonio.
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  • How far is Florence to San Antonio by plane?

    San Antonio is 1145.4 mi away from Florence. In terms of flight time, this usually takes a little over 6h 32m.

  • When did momondo last update prices for flights from Florence Airport to San Antonio Airport?

    Prices for flights from Florence Airport to San Antonio Airport refresh daily.

  • How old do you have to be to fly from Florence Airport to San Antonio Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Florence Airport to San Antonio Airport.

  • What documentation or ID do you need to fly to San Antonio Airport?

    The travel and health documents required for your trip to San Antonio Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Antonio Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville
Boerne
Schertz
Pleasanton

Why use momondo?

Why should I use momondo to find a flight deal from Florence to San Antonio?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Florence to San Antonio for you.

Can I find flights from Florence to San Antonio with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Antonio from Florence which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Florence to San Antonio?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Antonio from Florence.

I’m not ready to book a flight from Florence to San Antonio right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Florence to San Antonio flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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