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Cheap flights from Des Moines to San Jose from $108

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Jose departing on 1/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to San Jose

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:17 pm - 10:49 pm
DSM
-
SJC
6h 32m1 stop
American Airlines Logo
9:55 am - 8:04 pm
SJC
-
DSM
8h 09m1 stop
$210American Airlines
Thu, Jan 22 - Tue, Jan 27
American Airlines Logo
6:17 pm - 10:49 pm
DSM
-
SJC
6h 32m1 stop
American Airlines Logo
9:55 am - 11:08 pm
SJC
-
DSM
11h 13m2 stops
$215American Airlines
Thu, Jan 22 - Tue, Jan 27
American Airlines Logo
5:24 am - 12:10 pm
DSM
-
SJC
8h 46m1 stop
American Airlines Logo
2:32 pm - 11:23 pm
SJC
-
DSM
6h 51m1 stop
$236American Airlines
Wed, Jan 21 - Fri, Jan 23
Delta Logo
4:21 pm - 9:28 pm
DSM
-
SJC
7h 07m1 stop
Delta Logo
6:20 am - 3:41 pm
SJC
-
DSM
7h 21m1 stop
$237Delta
Tue, Jan 13 - Wed, Jan 14
American Airlines Logo
5:24 am - 12:10 pm
DSM
-
SJC
8h 46m1 stop
American Airlines Logo
6:00 am - 3:15 pm
SJC
-
DSM
7h 15m1 stop
$238American Airlines
Sat, Jan 17 - Sat, Jan 24
American Airlines Logo
5:21 am - 10:57 am
DSM
-
SJC
7h 36m1 stop
American Airlines Logo
2:32 pm - 11:23 pm
SJC
-
DSM
6h 51m1 stop
$241American Airlines
Thu, Jan 15 - Tue, Jan 20
Delta Logo
10:59 am - 7:12 pm
DSM
-
SJC
10h 13m2 stops
Delta Logo
10:45 pm - 10:38 am
SJC
-
DSM
9h 53m1 stop
$242Delta
Tue, Jan 13 - Wed, Jan 14
Delta Logo
10:59 am - 7:12 pm
DSM
-
SJC
10h 13m2 stops
Delta Logo
8:05 pm - 10:51 am
SJC
-
DSM
12h 46m2 stops
$247Delta
Thu, Jan 22 - Tue, Jan 27
Delta Logo
10:57 am - 8:19 pm
DSM
-
SJC
11h 22m2 stops
Delta Logo
6:30 am - 3:40 pm
SJC
-
DSM
7h 10m1 stop
$268Delta
Fri, Feb 27 - Mon, Mar 2
Delta Logo
10:57 am - 8:19 pm
DSM
-
SJC
11h 22m2 stops
Delta Logo
8:59 pm - 10:17 am
SJC
-
DSM
11h 18m2 stops
$273Delta
Fri, Feb 27 - Mon, Mar 2

American Airlines flights from Des Moines to San Jose, California

Our best American Airlines deals on Des Moines to San Jose, California flight tickets
American Airlines
Jan 22
DSM6:17 pmDes Moines
6h 32m
1 stop
SJC10:49 pmSan Jose
Jan 27
SJC9:55 amSan Jose
8h 09m
1 stop
DSM8:04 pmDes Moines
$210
Find similar
American Airlines
Jan 22
DSM6:17 pmDes Moines
6h 32m
1 stop
SJC10:49 pmSan Jose
Jan 27
SJC9:55 amSan Jose
11h 13m
2 stops
DSM11:08 pmDes Moines
$215
Find similar
American Airlines
Jan 21
DSM5:24 amDes Moines
8h 46m
1 stop
SJC12:10 pmSan Jose
Jan 23
SJC2:32 pmSan Jose
6h 51m
1 stop
DSM11:23 pmDes Moines
$236
Find similar

Delta flights from Des Moines to San Jose, California

Our best Delta deals on Des Moines to San Jose, California flight tickets
Delta
Jan 13
DSM4:21 pmDes Moines
7h 07m
1 stop
SJC9:28 pmSan Jose
Jan 14
SJC6:20 amSan Jose
7h 21m
1 stop
DSM3:41 pmDes Moines
$237
Find similar
Delta
Jan 13
DSM10:59 amDes Moines
10h 13m
2 stops
SJC7:12 pmSan Jose
Jan 14
SJC10:45 pmSan Jose
9h 53m
1 stop
DSM10:38 amDes Moines
$242
Find similar
Delta
Jan 22
DSM10:59 amDes Moines
10h 13m
2 stops
SJC7:12 pmSan Jose
Jan 27
SJC8:05 pmSan Jose
12h 46m
2 stops
DSM10:51 amDes Moines
$247
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Jose, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Des Moines to San Jose, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Thu 1/22

6:17 pm-10:49 pm

1 stop6h 32m

San Jose

Tue 1/27

9:55 am-8:04 pm

1 stop8h 09m

$210

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Thu 1/22

6:17 pm-10:49 pm

1 stop6h 32m

San Jose

Tue 1/27

9:55 am-11:08 pm

2 stops11h 13m

$215

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Wed 1/21

5:24 am-12:10 pm

1 stop8h 46m

San Jose

Fri 1/23

2:32 pm-11:23 pm

1 stop6h 51m

$236

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Tue 1/13

4:21 pm-9:28 pm

1 stop7h 07m

San Jose

Wed 1/14

6:20 am-3:41 pm

1 stop7h 21m

$237

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Sat 1/17

5:24 am-12:10 pm

1 stop8h 46m

San Jose

Sat 1/24

6:00 am-3:15 pm

1 stop7h 15m

$238

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Thu 1/15

5:21 am-10:57 am

1 stop7h 36m

San Jose

Tue 1/20

2:32 pm-11:23 pm

1 stop6h 51m

$241

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Tue 1/13

10:59 am-7:12 pm

2 stops10h 13m

San Jose

Wed 1/14

10:45 pm-10:38 am

1 stop9h 53m

$242

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Thu 1/22

10:59 am-7:12 pm

2 stops10h 13m

San Jose

Tue 1/27

8:05 pm-10:51 am

2 stops12h 46m

$247

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Fri 2/27

10:57 am-8:19 pm

2 stops11h 22m

San Jose

Mon 3/2

6:30 am-3:40 pm

1 stop7h 10m

$268

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Fri 2/27

10:57 am-8:19 pm

2 stops11h 22m

San Jose

Mon 3/2

8:59 pm-10:17 am

2 stops11h 18m

$273

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Jose from

How to get the cheapest flight ticket from Des Moines to San Jose, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Jose, California?

The month of April is, on average, the cheapest month to fly to San Jose, California from Des Moines, with most prices found around $356. If you are unable to visit San Jose, California during the month of April, then departing from Des Moines during the month August is also very affordable. Most momondo users find prices during this month for around $367.

What is the cheapest day to depart on your flight to San Jose, California?

On average, the least expensive day to fly to San Jose, California from Des Moines is on a Friday. momondo users have found tickets for Friday departures for as low as $407. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to San Jose, California for around $546.

What is the cheapest time of day to depart on your flight to San Jose, California?

The cheapest time of day to fly to San Jose, California is in the morning when flights can be purchased for as low as $436. In the afternoon is when there is more demand to fly to San Jose, California, so prices are often more expensive at around $482 per ticket.

When to book flights from Des Moines to San Jose, California

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Jose, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Jose, California (DSM to SJC) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Jose, California

Fastest flight time

5h 20m

Direct flights

None
The fastest flight from Des Moines to San Jose, California takes 5h 20m
There are no direct flights from Des Moines to San Jose, California. There are no popular flight routes from Des Moines to San Jose, California.
Search flight deals

  • How far is Des Moines to San Jose by plane?

    The straight-line distance from Des Moines to San Jose is 1527.5 mi. 5h 47m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to San Jose Airport?

    Prices for flights from Des Moines Airport to San Jose Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to San Jose Airport?

  • How old do you have to be to fly from Des Moines Airport to San Jose Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Jose Airport.

  • What documentation or ID do you need to fly to San Jose Airport?

    The travel and health documents you'll need for your trip to San Jose Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Jose Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to San Jose, California?

Best airlines flying from Des Moines to San Jose, California

Compare and see reviews for airlines that fly from Des Moines to San Jose, California with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $296Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
9,066 reviews
Search United Airlines flights
DeltaPriceFrom $302Free CancellationRating
7.9
8,011 reviews
Search Delta flights
SouthwestPriceFrom $356Free CancellationRating
8.0
4,250 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Jose?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to San Jose. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to San Jose with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Jose from Des Moines with this policy.

How can momondo help me find flights from Des Moines to San Jose?

momondo provides multiple filters to help you find the best flight to San Jose from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to San Jose right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to San Jose flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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