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Cheap flights from Des Moines to San Diego from $128

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Diego departing on 1/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:29 pm - 2:34 pm
DSM
-
SAN
20h 05m1 stop
Frontier Logo
6:36 am - 7:22 pm
SAN
-
DSM
10h 46m1 stop
$153Frontier
Mon, Jan 5 - Mon, Jan 12
Frontier Logo
7:45 pm - 10:45 am
DSM
-
SAN
17h 00m1 stop
Frontier Logo
6:25 am - 6:42 pm
SAN
-
DSM
10h 17m1 stop
$178Frontier
Sun, Feb 22 - Thu, Feb 26
Frontier Logo
8:17 pm - 2:34 pm
DSM
-
SAN
20h 17m1 stop
Frontier Logo
6:36 am - 7:22 pm
SAN
-
DSM
10h 46m1 stop
$182Frontier
Fri, Jan 9 - Mon, Jan 12
Multiple Airlines Logo
8:29 pm - 2:34 pm
DSM
-
SAN
20h 05m1 stop
Multiple Airlines Logo
10:52 am - 4:50 pm
SAN
-
DSM
27h 58m1 stop
$183Multiple Airlines
Mon, Jan 5 - Fri, Jan 9
Multiple Airlines Logo
8:29 pm - 2:34 pm
DSM
-
SAN
20h 05m1 stop
Multiple Airlines Logo
9:19 pm - 5:24 pm
SAN
-
DSM
18h 05m1 stop
$195Multiple Airlines
Mon, Jan 5 - Thu, Jan 8
Multiple Airlines Logo
7:30 am - 5:38 pm
DSM
-
SAN
12h 08m1 stop
Multiple Airlines Logo
7:21 pm - 9:21 pm
SAN
-
DSM
24h 00m1 stop
$201Multiple Airlines
Sun, Mar 29 - Thu, Apr 9
Frontier Logo
8:29 pm - 11:16 pm
DSM
-
SAN
28h 47m1 stop
Frontier Logo
9:19 pm - 7:22 pm
SAN
-
DSM
20h 03m2 stops
$209Frontier
Mon, Jan 5 - Sun, Jan 11
Multiple Airlines Logo
8:29 pm - 2:34 pm
DSM
-
SAN
20h 05m1 stop
Multiple Airlines Logo
9:19 pm - 5:24 pm
SAN
-
DSM
18h 05m1 stop
$213Multiple Airlines
Mon, Jan 5 - Sun, Jan 11
Multiple Airlines Logo
8:29 pm - 2:34 pm
DSM
-
SAN
20h 05m1 stop
Multiple Airlines Logo
2:50 pm - 4:50 pm
SAN
-
DSM
24h 00m2 stops
$214Multiple Airlines
Mon, Jan 5 - Fri, Jan 9
Frontier Logo
7:45 pm - 4:04 pm
DSM
-
SAN
22h 19m2 stops
Frontier Logo
6:25 am - 6:42 pm
SAN
-
DSM
10h 17m1 stop
$215Frontier
Sun, Feb 22 - Thu, Feb 26

United Airlines flights from Des Moines to San Diego

Our best United Airlines deals on Des Moines to San Diego flight tickets
United Airlines
Dec 24
DSM3:00 pmDes Moines
8h 56m
1 stop
SAN9:56 pmSan Diego
Dec 31
SAN4:10 pmSan Diego
5h 48m
1 stop
DSM11:58 pmDes Moines
$295
Find similar
United Airlines
Jan 6
DSM5:30 amDes Moines
5h 50m
1 stop
SAN9:20 amSan Diego
Jan 10
SAN11:08 amSan Diego
10h 36m
2 stops
DSM11:44 pmDes Moines
$302
Find similar
United Airlines
Jan 14
DSM1:35 pmDes Moines
8h 19m
2 stops
SAN7:54 pmSan Diego
Jan 21
SAN11:08 amSan Diego
7h 26m
2 stops
DSM8:34 pmDes Moines
$307
Find similar

Frontier flights from Des Moines to San Diego

Our best Frontier deals on Des Moines to San Diego flight tickets
Frontier
Jan 5
DSM8:29 pmDes Moines
20h 05m
1 stop
SAN2:34 pmSan Diego
Jan 12
SAN6:36 amSan Diego
10h 46m
1 stop
DSM7:22 pmDes Moines
$153
Find similar
Frontier
Feb 22
DSM7:45 pmDes Moines
17h 00m
1 stop
SAN10:45 amSan Diego
Feb 26
SAN6:25 amSan Diego
10h 17m
1 stop
DSM6:42 pmDes Moines
$178
Find similar
Frontier
Jan 9
DSM8:17 pmDes Moines
20h 17m
1 stop
SAN2:34 pmSan Diego
Jan 12
SAN6:36 amSan Diego
10h 46m
1 stop
DSM7:22 pmDes Moines
$182
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 1/5

8:29 pm-2:34 pm

1 stop20h 05m

San Diego

Mon 1/12

6:36 am-7:22 pm

1 stop10h 46m

$153

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Sun 2/22

7:45 pm-10:45 am

1 stop17h 00m

San Diego

Thu 2/26

6:25 am-6:42 pm

1 stop10h 17m

$178

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Fri 1/9

8:17 pm-2:34 pm

1 stop20h 17m

San Diego

Mon 1/12

6:36 am-7:22 pm

1 stop10h 46m

$182

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 1/5

8:29 pm-2:34 pm

1 stop20h 05m

San Diego

Fri 1/9

10:52 am-4:50 pm

1 stop27h 58m

$183

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 1/5

8:29 pm-2:34 pm

1 stop20h 05m

San Diego

Thu 1/8

9:19 pm-5:24 pm

1 stop18h 05m

$195

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Sun 3/29

7:30 am-5:38 pm

1 stop12h 08m

San Diego

Thu 4/9

7:21 pm-9:21 pm

1 stop24h 00m

$201

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 1/5

8:29 pm-11:16 pm

1 stop28h 47m

San Diego

Sun 1/11

9:19 pm-7:22 pm

2 stops20h 03m

$209

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 1/5

8:29 pm-2:34 pm

1 stop20h 05m

San Diego

Sun 1/11

9:19 pm-5:24 pm

1 stop18h 05m

$213

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 1/5

8:29 pm-2:34 pm

1 stop20h 05m

San Diego

Fri 1/9

2:50 pm-4:50 pm

2 stops24h 00m

$214

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Sun 2/22

7:45 pm-4:04 pm

2 stops22h 19m

San Diego

Thu 2/26

6:25 am-6:42 pm

1 stop10h 17m

$215

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Des Moines to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of June, then departing from Des Moines during the month August is also very affordable. Most momondo users find prices during this month for around $282.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Des Moines to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $161. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $468. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $170. Flights in the morning are often more expensive with an average ticket price of $433.

What is the cheapest Des Moines to San Diego flight route?

Fly from Des Moines to San Diego for the best Des Moines - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $370 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Des Moines for as low as $264 on momondo.

What cabin class options are available on Des Moines to San Diego flights?

There is only 1 cabin class available to choose from on Des Moines to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to San Diego flights?

No. A direct flight is the cheapest option for a flight between Des Moines to San Diego.

How have Des Moines to San Diego flight prices changed over time?

As of December 2025, prices for Des Moines to San Diego flights are approximately 9% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Diego (DSM to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Diego

Fastest flight time

5h 25m

Direct flights

None
The fastest flight from Des Moines to San Diego takes 5h 25m
There are no direct flights from Des Moines to San Diego. There are no popular flight routes from Des Moines to San Diego.
Search flight deals

  • How far is Des Moines to San Diego by plane?

    Des Moines and San Diego are 1426.2 mi apart from one another. In terms of flight time, this usually takes a little over 5h 25m.

  • When did momondo last update prices for flights from Des Moines Airport to San Diego Airport?

    Prices for flights from Des Moines Airport to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to San Diego Airport?

  • How old do you have to be to fly from Des Moines Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to San Diego?

  • What is the most popular airline from Des Moines to San Diego?

Best airlines flying from Des Moines to San Diego

Compare and see reviews for airlines that fly from Des Moines to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $104Free CancellationRating
7.2
700 reviews
Search Allegiant Air flights
FrontierPriceFrom $116Free CancellationRating
5.8
3,082 reviews
Search Frontier flights
DeltaPriceFrom $148Free CancellationRating
7.9
8,006 reviews
Search Delta flights
United AirlinesPriceFrom $282Free CancellationRating
7.4
9,092 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
11,053 reviews
Search American Airlines flights
SouthwestPriceFrom $307Free CancellationRating
7.9
4,249 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
Imperial Beach
Borrego Springs
La Mesa
San Ysidro
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Diego?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Diego from Des Moines.

Can I find flights from Des Moines to San Diego with flexible booking policies on momondo?

Flights from Des Moines to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Des Moines.

I’m not ready to book a flight from Des Moines to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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