Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to San Diego from $111

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Diego departing on 5/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
2:16 pm - 11:53 pm
DSM
-
SAN
11h 37m
1 stop
Frontier Logo
6:25 am - 1:31 pm
SAN
-
DSM
5h 06m
1 stop
$210Frontier
Wed, Jun 10 - Wed, Jun 17
Frontier Logo
2:16 pm - 11:53 pm
DSM
-
SAN
11h 37m
1 stop
Frontier Logo
6:25 am - 1:31 pm
SAN
-
DSM
5h 06m
1 stop
$213Frontier
Wed, Jun 10 - Wed, Jun 17
Multiple Airlines Logo
2:16 pm - 11:53 pm
DSM
-
SAN
11h 37m
1 stop
Multiple Airlines Logo
9:43 am - 12:59 pm
SAN
-
DSM
25h 16m
1 stop
$216Multiple Airlines
Wed, Jun 24 - Tue, Jun 30
Frontier Logo
2:16 pm - 11:53 pm
DSM
-
SAN
11h 37m
1 stop
Frontier Logo
6:25 am - 1:31 pm
SAN
-
DSM
5h 06m
1 stop
$224Frontier
Wed, Jun 24 - Wed, Jul 1
Multiple Airlines Logo
10:01 pm - 8:58 pm
DSM
-
SAN
24h 57m
1 stop
Multiple Airlines Logo
9:53 pm - 12:59 pm
SAN
-
DSM
13h 06m
1 stop
$228Multiple Airlines
Mon, Jul 20 - Tue, Jul 28
Multiple Airlines Logo
10:01 pm - 8:58 pm
DSM
-
SAN
24h 57m
1 stop
Multiple Airlines Logo
9:53 pm - 12:59 pm
SAN
-
DSM
13h 06m
1 stop
$229Multiple Airlines
Mon, Jul 20 - Tue, Jul 28
Frontier Logo
2:16 pm - 11:53 pm
DSM
-
SAN
11h 37m
1 stop
Frontier Logo
6:25 am - 1:31 pm
SAN
-
DSM
5h 06m
1 stop
$230Frontier
Wed, Jun 24 - Fri, Jun 26
Frontier Logo
2:16 pm - 11:53 pm
DSM
-
SAN
11h 37m
1 stop
Frontier Logo
6:25 am - 1:31 pm
SAN
-
DSM
5h 06m
1 stop
$231Frontier
Wed, Jun 17 - Wed, Jun 24
Frontier Logo
2:16 pm - 11:53 pm
DSM
-
SAN
11h 37m
1 stop
Frontier Logo
6:25 am - 1:31 pm
SAN
-
DSM
5h 06m
1 stop
$233Frontier
Wed, Jun 17 - Wed, Jun 24
Frontier Logo
2:16 pm - 11:53 pm
DSM
-
SAN
11h 37m
1 stop
Frontier Logo
6:25 am - 1:31 pm
SAN
-
DSM
5h 06m
1 stop
$236Frontier
Wed, Jun 17 - Wed, Jun 24

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Frontier flights from Des Moines to San Diego

Our best Frontier deals on Des Moines to San Diego flight tickets
Frontier
Jun 10
DSM2:16 pmDes Moines
11h 37m
1 stop
SAN11:53 pmSan Diego
Jun 17
SAN6:25 amSan Diego
5h 06m
1 stop
DSM1:31 pmDes Moines
$210
Frontier
Jun 10
DSM2:16 pmDes Moines
11h 37m
1 stop
SAN11:53 pmSan Diego
Jun 17
SAN6:25 amSan Diego
5h 06m
1 stop
DSM1:31 pmDes Moines
$213
Frontier
Jun 24
DSM2:16 pmDes Moines
11h 37m
1 stop
SAN11:53 pmSan Diego
Jul 1
SAN6:25 amSan Diego
5h 06m
1 stop
DSM1:31 pmDes Moines
$224

American Airlines flights from Des Moines to San Diego

Our best American Airlines deals on Des Moines to San Diego flight tickets
American Airlines
May 12
DSM5:19 amDes Moines
12h 28m
1 stop
SAN3:47 pmSan Diego
May 17
SAN10:40 pmSan Diego
7h 46m
1 stop
DSM8:26 amDes Moines
$702
American Airlines
May 13
DSM5:19 amDes Moines
12h 28m
1 stop
SAN3:47 pmSan Diego
May 20
SAN2:04 pmSan Diego
7h 55m
1 stop
DSM11:59 pmDes Moines
$712
American Airlines
May 8
DSM5:19 amDes Moines
12h 40m
1 stop
SAN3:59 pmSan Diego
May 16
SAN3:12 pmSan Diego
6h 47m
1 stop
DSM11:59 pmDes Moines
$727

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 4, 2026.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 6/10

2:16 pm-11:53 pm

1 stop11h 37m

San Diego

Wed 6/17

6:25 am-1:31 pm

1 stop5h 06m

$210

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 6/10

2:16 pm-11:53 pm

1 stop11h 37m

San Diego

Wed 6/17

6:25 am-1:31 pm

1 stop5h 06m

$213

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 6/24

2:16 pm-11:53 pm

1 stop11h 37m

San Diego

Tue 6/30

9:43 am-12:59 pm

1 stop25h 16m

$216

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 6/24

2:16 pm-11:53 pm

1 stop11h 37m

San Diego

Wed 7/1

6:25 am-1:31 pm

1 stop5h 06m

$224

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 7/20

10:01 pm-8:58 pm

1 stop24h 57m

San Diego

Tue 7/28

9:53 pm-12:59 pm

1 stop13h 06m

$228

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 7/20

10:01 pm-8:58 pm

1 stop24h 57m

San Diego

Tue 7/28

9:53 pm-12:59 pm

1 stop13h 06m

$229

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 6/24

2:16 pm-11:53 pm

1 stop11h 37m

San Diego

Fri 6/26

6:25 am-1:31 pm

1 stop5h 06m

$230

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 6/17

2:16 pm-11:53 pm

1 stop11h 37m

San Diego

Wed 6/24

6:25 am-1:31 pm

1 stop5h 06m

$231

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 6/17

2:16 pm-11:53 pm

1 stop11h 37m

San Diego

Wed 6/24

6:25 am-1:31 pm

1 stop5h 06m

$233

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 6/17

2:16 pm-11:53 pm

1 stop11h 37m

San Diego

Wed 6/24

6:25 am-1:31 pm

1 stop5h 06m

$236

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Diego from

How to get the cheapest flight ticket from Des Moines to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Diego?

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of August, then departing from Des Moines during the month September is also very affordable. Most momondo users find prices during this month for around $303.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Des Moines to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $148. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $158. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest Des Moines to San Diego flight route?

Fly from Des Moines to San Diego for the best Des Moines - San Diego flight prices

How far in advance should I book a flight from Des Moines to San Diego?

You are more likely to see cheaper flights to San Diego from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $372 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Des Moines for as low as $313 on momondo.

Can stopping save me money on Des Moines to San Diego flights?

You could potentially save up to 7% on your flight if you consider stops on a Des Moines to San Diego flight.

How have Des Moines to San Diego flight prices changed over time?

As of May 2026, prices for Des Moines to San Diego flights are approximately 27% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Diego (DSM to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Diego

Fastest flight time

8h 03m

Direct flights

None
The fastest flight from Des Moines to San Diego takes 8h 03m
There are no direct flights from Des Moines to San Diego. There are no popular flight routes from Des Moines to San Diego.
Search flight deals

Frequently asked questions about flying from Des Moines to San Diego

  • How far is Des Moines to San Diego by plane?

    Des Moines and San Diego are 1426.2 mi apart from one another. In terms of flight time, this usually takes a little over 8h 03m.

  • When did momondo last update prices for flights from Des Moines Airport to San Diego Airport?

    Prices for flights from Des Moines Airport to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to San Diego Airport?

  • How old do you have to be to fly from Des Moines Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to San Diego?

  • What is the most popular airline from Des Moines to San Diego?

Best airlines flying from Des Moines to San Diego

Compare and see reviews for airlines that fly from Des Moines to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $100Free CancellationRating
5.6
2,965 reviews
Search Frontier flights
Allegiant AirPriceFrom $101Free CancellationRating
7.3
707 reviews
Search Allegiant Air flights
DeltaPriceFrom $118Free CancellationRating
7.9
8,459 reviews
Search Delta flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
9,681 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.1
11,670 reviews
Search American Airlines flights
SouthwestPriceFrom $303Free CancellationRating
7.9
4,306 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
San Ysidro
La Mesa
Imperial Beach
Borrego Springs
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Diego?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Diego from Des Moines.

Can I find flights from Des Moines to San Diego with flexible booking policies on momondo?

Flights from Des Moines to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Des Moines.

I’m not ready to book a flight from Des Moines to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your San Diego trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 6/3
Wed 6/10
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States