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Cheap flights from Des Moines to San Diego from $77

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Diego departing on 10/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to San Diego

Cheap round-trip flights

Logo
3:30 pm - 11:17 pmDSM-SAN
9h 47m1 stop
Logo
1:35 pm - 10:37 pmSAN-DSM
7h 02m1 stop
$204
Find Deal
Mon, Sep 29 - Fri, Oct 3
American Airlines Logo
2:28 pm - 8:00 pmDSM-SAN
7h 32m1 stop
American Airlines Logo
6:16 am - 5:37 pmSAN-DSM
9h 21m1 stop
$209American Airlines
Find Deal
Wed, Oct 29 - Sat, Nov 1
Logo
7:30 am - 9:20 pmDSM-SAN
15h 50m1 stop
Logo
2:11 pm - 4:06 pmSAN-DSM
23h 55m1 stop
$216
Find Deal
Wed, Oct 15 - Tue, Oct 21
Frontier Logo
2:32 pm - 11:50 pmDSM-SAN
11h 18m1 stop
Frontier Logo
6:41 am - 1:47 pmSAN-DSM
5h 06m1 stop
$225Frontier
Find Deal
Thu, Oct 30 - Mon, Nov 3
Frontier Logo
2:25 pm - 8:07 pmDSM-SAN
7h 42m1 stop
Frontier Logo
6:35 am - 1:40 pmSAN-DSM
5h 05m1 stop
$226Frontier
Find Deal
Thu, Sep 25 - Sun, Sep 28
Southwest Logo
7:25 am - 12:30 pmDSM-SAN
7h 05m1 stop
Southwest Logo
8:30 am - 4:00 pmSAN-DSM
5h 30m1 stop
$239Southwest
Find Deal
Tue, Oct 7 - Tue, Oct 14
Southwest Logo
10:15 am - 4:40 pmDSM-SAN
8h 25m2 stops
Southwest Logo
6:25 am - 4:00 pmSAN-DSM
7h 35m2 stops
$249Southwest
Find Deal
Tue, Oct 7 - Tue, Oct 14
United Airlines Logo
5:15 pm - 11:42 pmDSM-SAN
8h 27m2 stops
United Airlines Logo
12:50 pm - 8:48 pmSAN-DSM
5h 58m1 stop
$302United Airlines
Find Deal
Wed, Dec 10 - Wed, Dec 17
United Airlines Logo
1:05 pm - 11:44 pmDSM-SAN
12h 39m2 stops
United Airlines Logo
4:10 pm - 11:44 pmSAN-DSM
5h 34m1 stop
$331United Airlines
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Wed, Nov 12 - Mon, Nov 17
Delta Logo
11:06 am - 10:31 pmDSM-SAN
13h 25m2 stops
Delta Logo
7:25 am - 4:52 pmSAN-DSM
7h 27m1 stop
$346Delta
Find Deal
Wed, Oct 29 - Sat, Nov 1

Frontier flights from Des Moines to San Diego

Our best Frontier deals on Des Moines to San Diego flight tickets
Frontier
Oct 30
DSM2:32 pmDes Moines
11h 18m
1 stop
SAN11:50 pmSan Diego
Nov 3
SAN6:41 amSan Diego
5h 06m
1 stop
DSM1:47 pmDes Moines
$225
Find similar
Frontier
Sep 25
DSM2:25 pmDes Moines
7h 42m
1 stop
SAN8:07 pmSan Diego
Sep 28
SAN6:35 amSan Diego
5h 05m
1 stop
DSM1:40 pmDes Moines
$226
Find similar
Frontier
Nov 7
DSM2:32 pmDes Moines
11h 18m
1 stop
SAN11:50 pmSan Diego
Nov 9
SAN6:41 amSan Diego
5h 06m
1 stop
DSM1:47 pmDes Moines
$227
Find similar

Southwest flights from Des Moines to San Diego

Our best Southwest deals on Des Moines to San Diego flight tickets
Southwest
Oct 7
DSM7:25 amDes Moines
7h 05m
1 stop
SAN12:30 pmSan Diego
Oct 14
SAN8:30 amSan Diego
5h 30m
1 stop
DSM4:00 pmDes Moines
$239
Find similar
Southwest
Oct 7
DSM10:15 amDes Moines
8h 25m
2 stops
SAN4:40 pmSan Diego
Oct 14
SAN6:25 amSan Diego
7h 35m
2 stops
DSM4:00 pmDes Moines
$249
Find similar
Southwest
Nov 14
DSM5:45 amDes Moines
10h 20m
2 stops
SAN2:05 pmSan Diego
Nov 18
SAN10:30 amSan Diego
7h 25m
2 stops
DSM7:55 pmDes Moines
$322
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 9/29

3:30 pm-11:17 pm

1 stop9h 47m

San Diego

Fri 10/3

1:35 pm-10:37 pm

1 stop7h 02m

$204

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 10/29

2:28 pm-8:00 pm

1 stop7h 32m

San Diego

Sat 11/1

6:16 am-5:37 pm

1 stop9h 21m

$209

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 10/15

7:30 am-9:20 pm

1 stop15h 50m

San Diego

Tue 10/21

2:11 pm-4:06 pm

1 stop23h 55m

$216

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Thu 10/30

2:32 pm-11:50 pm

1 stop11h 18m

San Diego

Mon 11/3

6:41 am-1:47 pm

1 stop5h 06m

$225

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Thu 9/25

2:25 pm-8:07 pm

1 stop7h 42m

San Diego

Sun 9/28

6:35 am-1:40 pm

1 stop5h 05m

$226

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 10/7

7:25 am-12:30 pm

1 stop7h 05m

San Diego

Tue 10/14

8:30 am-4:00 pm

1 stop5h 30m

$239

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 10/7

10:15 am-4:40 pm

2 stops8h 25m

San Diego

Tue 10/14

6:25 am-4:00 pm

2 stops7h 35m

$249

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 12/10

5:15 pm-11:42 pm

2 stops8h 27m

San Diego

Wed 12/17

12:50 pm-8:48 pm

1 stop5h 58m

$302

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 11/12

1:05 pm-11:44 pm

2 stops12h 39m

San Diego

Mon 11/17

4:10 pm-11:44 pm

1 stop5h 34m

$331

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 10/29

11:06 am-10:31 pm

2 stops13h 25m

San Diego

Sat 11/1

7:25 am-4:52 pm

1 stop7h 27m

$346

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Des Moines to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of June, then departing from Des Moines during the month August is also very affordable. Most momondo users find prices during this month for around $282.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Des Moines to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $161. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $468. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $170. Flights in the morning are often more expensive with an average ticket price of $433.

What is the cheapest Des Moines to San Diego flight route?

Fly from Des Moines to San Diego for the best Des Moines - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $375 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Des Moines for as low as $291 on momondo.

What cabin class options are available on Des Moines to San Diego flights?

There is only 1 cabin class available to choose from on Des Moines to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to San Diego flights?

No. A direct flight is the cheapest option for a flight between Des Moines to San Diego.

How have Des Moines to San Diego flight prices changed over time?

As of September 2025, prices for Des Moines to San Diego flights are approximately 10% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Diego (DSM to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Diego

Direct flights

None
There are no direct flights from Des Moines to San Diego. There are no popular flight routes from Des Moines to San Diego.
Search flight deals

  • How far is Des Moines to San Diego by plane?

    Des Moines and San Diego are 1426.2 mi apart from one another. In terms of flight time, this usually takes a little over 5h 29m.

  • When did momondo last update prices for flights from Des Moines Airport to San Diego Airport?

    Prices for flights from Des Moines Airport to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to San Diego Airport?

  • How old do you have to be to fly from Des Moines Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to San Diego?

  • What is the most popular airline from Des Moines to San Diego?

Best airlines flying from Des Moines to San Diego

Compare and see reviews for airlines that fly from Des Moines to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $104Free CancellationRating
7.2
699 reviews
Search Allegiant Air flights
FrontierPriceFrom $119Free CancellationRating
5.8
3,172 reviews
Search Frontier flights
United AirlinesPriceFrom $282Free CancellationRating
7.4
8,929 reviews
Search United Airlines flights
DeltaPriceFrom $284Free CancellationRating
7.9
7,954 reviews
Search Delta flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $334Free CancellationRating
8.0
4,242 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
La Mesa
National City
Poway
Imperial Beach
San Ysidro
Borrego Springs
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Diego?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Diego from Des Moines.

Can I find flights from Des Moines to San Diego with flexible booking policies on momondo?

Flights from Des Moines to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Des Moines.

I’m not ready to book a flight from Des Moines to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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