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Cheap flights from Des Moines to San Diego from $95

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Diego departing on 7/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:01 pm - 2:08 pm
DSM
-
SAN
18h 07m
1 stop
Multiple Airlines Logo
3:03 pm - 12:59 pm
SAN
-
DSM
19h 56m
1 stop
$187Multiple Airlines
Mon, Jul 13 - Tue, Jul 21
Multiple Airlines Logo
10:01 pm - 2:08 pm
DSM
-
SAN
18h 07m
1 stop
Multiple Airlines Logo
3:03 pm - 12:59 pm
SAN
-
DSM
19h 56m
1 stop
$192Multiple Airlines
Mon, Jul 13 - Tue, Jul 21
Multiple Airlines Logo
10:01 pm - 2:08 pm
DSM
-
SAN
18h 07m
1 stop
Multiple Airlines Logo
4:12 pm - 12:59 pm
SAN
-
DSM
18h 47m
2 stops
$195Multiple Airlines
Mon, Jul 13 - Tue, Jul 21
Multiple Airlines Logo
10:01 pm - 2:08 pm
DSM
-
SAN
18h 07m
1 stop
Multiple Airlines Logo
3:03 pm - 12:59 pm
SAN
-
DSM
19h 56m
1 stop
$206Multiple Airlines
Mon, Jul 13 - Tue, Jul 21
Multiple Airlines Logo
10:01 pm - 3:27 pm
DSM
-
SAN
19h 26m
2 stops
Multiple Airlines Logo
3:03 pm - 12:59 pm
SAN
-
DSM
19h 56m
1 stop
$216Multiple Airlines
Mon, Jul 13 - Tue, Jul 21
Multiple Airlines Logo
10:01 pm - 8:06 pm
DSM
-
SAN
24h 05m
1 stop
Multiple Airlines Logo
3:03 pm - 12:59 pm
SAN
-
DSM
19h 56m
1 stop
$217Multiple Airlines
Fri, Jul 31 - Tue, Aug 4
Multiple Airlines Logo
10:01 pm - 3:27 pm
DSM
-
SAN
19h 26m
2 stops
Multiple Airlines Logo
3:03 pm - 12:59 pm
SAN
-
DSM
19h 56m
1 stop
$230Multiple Airlines
Mon, Jul 13 - Tue, Jul 21
Multiple Airlines Logo
10:01 pm - 8:06 pm
DSM
-
SAN
24h 05m
1 stop
Multiple Airlines Logo
4:12 pm - 12:59 pm
SAN
-
DSM
18h 47m
2 stops
$236Multiple Airlines
Fri, Jul 31 - Tue, Aug 4
Multiple Airlines Logo
9:50 pm - 8:58 pm
DSM
-
SAN
25h 08m
1 stop
Multiple Airlines Logo
9:53 pm - 6:48 pm
SAN
-
DSM
18h 55m
1 stop
$245Multiple Airlines
Sun, Aug 23 - Thu, Aug 27
Multiple Airlines Logo
10:01 pm - 8:06 pm
DSM
-
SAN
24h 05m
1 stop
Multiple Airlines Logo
3:03 pm - 8:54 pm
SAN
-
DSM
27h 51m
1 stop
$246Multiple Airlines
Fri, Jul 31 - Wed, Aug 5

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Frontier flights from Des Moines to San Diego

Our best Frontier deals on Des Moines to San Diego flight tickets
Frontier
Aug 5
DSM2:19 pmDes Moines
11h 32m
1 stop
SAN11:51 pmSan Diego
Aug 12
SAN6:25 amSan Diego
5h 09m
1 stop
DSM1:34 pmDes Moines
$249
Frontier
Aug 26
DSM2:16 pmDes Moines
11h 37m
1 stop
SAN11:53 pmSan Diego
Aug 31
SAN6:25 amSan Diego
5h 06m
1 stop
DSM1:31 pmDes Moines
$252
Frontier
Aug 17
DSM2:19 pmDes Moines
11h 32m
1 stop
SAN11:51 pmSan Diego
Aug 24
SAN6:25 amSan Diego
5h 06m
1 stop
DSM1:31 pmDes Moines
$256

United Airlines flights from Des Moines to San Diego

Our best United Airlines deals on Des Moines to San Diego flight tickets
United Airlines
Jul 1
DSM5:17 pmDes Moines
5h 29m
1 stop
SAN8:46 pmSan Diego
Jul 8
SAN6:20 amSan Diego
7h 55m
2 stops
DSM4:15 pmDes Moines
$362
United Airlines
Jun 28
DSM1:40 pmDes Moines
5h 40m
1 stop
SAN5:20 pmSan Diego
Jul 1
SAN6:35 amSan Diego
7h 40m
1 stop
DSM4:15 pmDes Moines
$467
United Airlines
Jul 2
DSM11:23 amDes Moines
14h 31m
2 stops
SAN11:54 pmSan Diego
Jul 7
SAN10:49 amSan Diego
10h 07m
2 stops
DSM10:56 pmDes Moines
$557

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 19, 2026.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 7/13

10:01 pm-2:08 pm

1 stop18h 07m

San Diego

Tue 7/21

3:03 pm-12:59 pm

1 stop19h 56m

$187

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 7/13

10:01 pm-2:08 pm

1 stop18h 07m

San Diego

Tue 7/21

3:03 pm-12:59 pm

1 stop19h 56m

$192
Quickest round-trip

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 7/13

10:01 pm-2:08 pm

1 stop18h 07m

San Diego

Tue 7/21

4:12 pm-12:59 pm

2 stops18h 47m

$195

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 7/13

10:01 pm-2:08 pm

1 stop18h 07m

San Diego

Tue 7/21

3:03 pm-12:59 pm

1 stop19h 56m

$206

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 7/13

10:01 pm-3:27 pm

2 stops19h 26m

San Diego

Tue 7/21

3:03 pm-12:59 pm

1 stop19h 56m

$216

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Fri 7/31

10:01 pm-8:06 pm

1 stop24h 05m

San Diego

Tue 8/4

3:03 pm-12:59 pm

1 stop19h 56m

$217

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 7/13

10:01 pm-3:27 pm

2 stops19h 26m

San Diego

Tue 7/21

3:03 pm-12:59 pm

1 stop19h 56m

$230

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Fri 7/31

10:01 pm-8:06 pm

1 stop24h 05m

San Diego

Tue 8/4

4:12 pm-12:59 pm

2 stops18h 47m

$236

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Sun 8/23

9:50 pm-8:58 pm

1 stop25h 08m

San Diego

Thu 8/27

9:53 pm-6:48 pm

1 stop18h 55m

$245

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Fri 7/31

10:01 pm-8:06 pm

1 stop24h 05m

San Diego

Wed 8/5

3:03 pm-8:54 pm

1 stop27h 51m

$246

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Des Moines to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Diego?

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of August, then departing from Des Moines during the month September is also very affordable. Most momondo users find prices during this month for around $314.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Des Moines to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $144. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $167. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest Des Moines to San Diego flight route?

Fly from Des Moines to San Diego for the best Des Moines - San Diego flight prices

How far in advance should I book a flight from Des Moines to San Diego?

You are more likely to see cheaper flights to San Diego from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $381 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Des Moines for as low as $325 on momondo.

What cabin class options are available on Des Moines to San Diego flights?

There is only 1 cabin class available to choose from on Des Moines to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to San Diego flights?

No. A direct flight is the cheapest option for a flight between Des Moines to San Diego.

How have Des Moines to San Diego flight prices changed over time?

As of June 2026, prices for Des Moines to San Diego flights are approximately 22% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Diego (DSM to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Diego

Fastest flight time

5h 17m

Direct flights

None
The fastest flight from Des Moines to San Diego takes 5h 17m
There are no direct flights from Des Moines to San Diego. There are no popular flight routes from Des Moines to San Diego.
Search flight deals

Frequently asked questions about flying from Des Moines to San Diego

  • How far is Des Moines to San Diego by plane?

    Des Moines and San Diego are 1426.2 mi apart from one another. In terms of flight time, this usually takes a little over 5h 17m.

  • When did momondo last update prices for flights from Des Moines Airport to San Diego Airport?

    Prices for flights from Des Moines Airport to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to San Diego Airport?

  • How old do you have to be to fly from Des Moines Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to San Diego?

  • What is the most popular airline from Des Moines to San Diego?

Best airlines flying from Des Moines to San Diego

Compare and see reviews for airlines that fly from Des Moines to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $89Free CancellationRating
7.3
692 reviews
Search Allegiant Air flights
FrontierPriceFrom $100Free CancellationRating
5.6
2,879 reviews
Search Frontier flights
DeltaPriceFrom $118Free CancellationRating
7.8
8,420 reviews
Search Delta flights
American AirlinesPriceFrom $286Free CancellationRating
7.1
11,709 reviews
Search American Airlines flights
SouthwestPriceFrom $296Free CancellationRating
7.9
4,241 reviews
Search Southwest flights
United AirlinesPriceFrom $310Free CancellationRating
7.4
9,865 reviews
Search United Airlines flights

  • Southwest Flights From Des Moines to San Diego

    Southwest flight deals from Des Moines to San Diego start from $296 round-trip. Over the 3 Southwest flights for this route in a normal week, average airfare is usually $476 round-trip - but some users have found much cheaper deals with momondo.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
Coronado
El Cajon
Julian
National City
Poway
La Mesa
San Ysidro
Borrego Springs
Imperial Beach
Lemon Grove
Santee
Alpine

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Diego?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Diego from Des Moines.

Can I find flights from Des Moines to San Diego with flexible booking policies on momondo?

Flights from Des Moines to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Des Moines.

I’m not ready to book a flight from Des Moines to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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