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Cheap flights from Des Moines to San Diego from $88

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Diego departing on 8/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:56 pm - 8:17 pm
DSM
-
SAN
24h 21m
1 stop
Multiple Airlines Logo
9:03 pm - 10:57 am
SAN
-
DSM
11h 54m
1 stop
$194Multiple Airlines
Sun, Sep 27 - Thu, Oct 1
Multiple Airlines Logo
9:56 pm - 8:17 pm
DSM
-
SAN
24h 21m
1 stop
Multiple Airlines Logo
7:04 pm - 2:31 pm
SAN
-
DSM
17h 27m
1 stop
$197Multiple Airlines
Sun, Sep 20 - Fri, Sep 25
Frontier Logo
8:30 pm - 3:59 pm
DSM
-
SAN
21h 29m
1 stop
Frontier Logo
6:25 am - 7:33 pm
SAN
-
DSM
11h 08m
1 stop
$207Frontier
Mon, Sep 14 - Mon, Sep 21
Frontier Logo
8:30 pm - 3:59 pm
DSM
-
SAN
21h 29m
1 stop
Frontier Logo
6:25 am - 7:33 pm
SAN
-
DSM
11h 08m
1 stop
$210Frontier
Mon, Sep 14 - Mon, Sep 21
United Airlines Logo
5:45 am - 9:05 am
DSM
-
SAN
5h 20m
1 stop
United Airlines Logo
6:18 am - 5:28 pm
SAN
-
DSM
9h 10m
1 stop
$350United Airlines
Tue, Aug 25 - Thu, Aug 27
United Airlines Logo
5:21 pm - 8:34 pm
DSM
-
SAN
5h 13m
1 stop
United Airlines Logo
6:18 am - 5:28 pm
SAN
-
DSM
9h 10m
1 stop
$350United Airlines
Tue, Aug 25 - Sat, Aug 29
Southwest Logo
7:15 am - 1:30 pm
DSM
-
SAN
8h 15m
1 stop
Southwest Logo
11:45 am - 9:05 pm
SAN
-
DSM
7h 20m
1 stop
$355Southwest
Tue, Sep 1 - Tue, Sep 15
Delta Logo
2:46 pm - 8:37 pm
DSM
-
SAN
7h 51m
1 stop
Delta Logo
6:25 am - 2:06 pm
SAN
-
DSM
5h 41m
1 stop
$355Delta
Wed, Sep 16 - Sat, Sep 19
Southwest Logo
7:05 am - 1:05 pm
DSM
-
SAN
8h 00m
2 stops
Southwest Logo
11:10 am - 8:35 pm
SAN
-
DSM
7h 25m
1 stop
$360Southwest
Wed, Dec 2 - Sat, Dec 12
Delta Logo
2:45 pm - 8:16 pm
DSM
-
SAN
7h 31m
1 stop
Delta Logo
6:29 am - 2:04 pm
SAN
-
DSM
5h 35m
1 stop
$385Delta
Wed, Aug 26 - Thu, Aug 27

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Frontier flights from Des Moines to San Diego

Our best Frontier deals on Des Moines to San Diego flight tickets
Frontier
Sep 14
DSM8:30 pmDes Moines
21h 29m
1 stop
SAN3:59 pmSan Diego
Sep 21
SAN6:25 amSan Diego
11h 08m
1 stop
DSM7:33 pmDes Moines
$207
Frontier
Sep 14
DSM8:30 pmDes Moines
21h 29m
1 stop
SAN3:59 pmSan Diego
Sep 21
SAN6:25 amSan Diego
11h 08m
1 stop
DSM7:33 pmDes Moines
$210
Frontier
Sep 24
DSM11:29 amDes Moines
6h 30m
1 stop
SAN3:59 pmSan Diego
Sep 30
SAN4:54 pmSan Diego
15h 50m
1 stop
DSM10:44 amDes Moines
$212

American Airlines flights from Des Moines to San Diego

Our best American Airlines deals on Des Moines to San Diego flight tickets
American Airlines
Aug 11
DSM4:13 pmDes Moines
6h 50m
1 stop
SAN9:03 pmSan Diego
Aug 16
SAN6:25 amSan Diego
5h 04m
1 stop
DSM1:29 pmDes Moines
$797
American Airlines
Aug 4
DSM5:45 amDes Moines
11h 41m
1 stop
SAN3:26 pmSan Diego
Aug 9
SAN9:40 amSan Diego
12h 17m
1 stop
DSM11:57 pmDes Moines
$902
American Airlines
Aug 3
DSM2:26 pmDes Moines
5h 52m
1 stop
SAN6:18 pmSan Diego
Aug 10
SAN10:45 pmSan Diego
9h 11m
1 stop
DSM9:56 amDes Moines
$1,012

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 2, 2026.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Sun 9/27

9:56 pm-8:17 pm

1 stop24h 21m

San Diego

Thu 10/1

9:03 pm-10:57 am

1 stop11h 54m

$194

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Sun 9/20

9:56 pm-8:17 pm

1 stop24h 21m

San Diego

Fri 9/25

7:04 pm-2:31 pm

1 stop17h 27m

$197

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 9/14

8:30 pm-3:59 pm

1 stop21h 29m

San Diego

Mon 9/21

6:25 am-7:33 pm

1 stop11h 08m

$207

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 9/14

8:30 pm-3:59 pm

1 stop21h 29m

San Diego

Mon 9/21

6:25 am-7:33 pm

1 stop11h 08m

$210

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 8/25

5:45 am-9:05 am

1 stop5h 20m

San Diego

Thu 8/27

6:18 am-5:28 pm

1 stop9h 10m

$350

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 8/25

5:21 pm-8:34 pm

1 stop5h 13m

San Diego

Sat 8/29

6:18 am-5:28 pm

1 stop9h 10m

$350

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 9/1

7:15 am-1:30 pm

1 stop8h 15m

San Diego

Tue 9/15

11:45 am-9:05 pm

1 stop7h 20m

$355

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 9/16

2:46 pm-8:37 pm

1 stop7h 51m

San Diego

Sat 9/19

6:25 am-2:06 pm

1 stop5h 41m

$355

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 12/2

7:05 am-1:05 pm

2 stops8h 00m

San Diego

Sat 12/12

11:10 am-8:35 pm

1 stop7h 25m

$360
Quickest round-trip

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 8/26

2:45 pm-8:16 pm

1 stop7h 31m

San Diego

Thu 8/27

6:29 am-2:04 pm

1 stop5h 35m

$385

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Diego from

How to get the cheapest flight ticket from Des Moines to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Diego?

Prices are currently low for flights on this route.

Typical prices usually range from $286 to $471.
The lowest price recently found on this route was $194.

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of December, then departing from Des Moines during the month September is also very affordable. Most momondo users find prices during this month for around $346.

What is the cheapest Des Moines to San Diego flight route?

Fly from Des Moines to San Diego for the best Des Moines - San Diego flight prices

How far in advance should I book a flight from Des Moines to San Diego?

You are more likely to see cheaper flights to San Diego from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $404 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Des Moines for as low as $351 on momondo.

What cabin class options are available on Des Moines to San Diego flights?

There is only 1 cabin class available to choose from on Des Moines to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to San Diego flights?

No. A direct flight is the cheapest option for a flight between Des Moines to San Diego.

How have Des Moines to San Diego flight prices changed over time?

As of August 2026, prices for Des Moines to San Diego flights are approximately 43% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Diego (DSM to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Diego

Fastest flight time

4h 50m

Direct flights

None
The fastest flight from Des Moines to San Diego takes 4h 50m
There are no direct flights from Des Moines to San Diego. There are no popular flight routes from Des Moines to San Diego.
Search flight deals

Frequently asked questions about flying from Des Moines to San Diego

  • How far is Des Moines to San Diego by plane?

    Des Moines and San Diego are 1426.2 mi apart from one another. In terms of flight time, this usually takes a little over 4h 50m.

  • When did momondo last update prices for flights from Des Moines Airport to San Diego Airport?

    Prices for flights from Des Moines Airport to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to San Diego Airport?

  • How old do you have to be to fly from Des Moines Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to San Diego?

  • What is the most popular airline from Des Moines to San Diego?

Best airlines flying from Des Moines to San Diego

Compare and see reviews for airlines that fly from Des Moines to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $100Free CancellationRating
5.6
2,741 reviews
Search Frontier flights
DeltaPriceFrom $118Free CancellationRating
7.8
8,493 reviews
Search Delta flights
American AirlinesPriceFrom $286Free CancellationRating
7.1
11,846 reviews
Search American Airlines flights
SouthwestPriceFrom $296Free CancellationRating
8.0
4,229 reviews
Search Southwest flights
United AirlinesPriceFrom $310Free CancellationRating
7.4
10,061 reviews
Search United Airlines flights

  • Southwest Flights From Des Moines to San Diego

    Southwest flight deals from Des Moines to San Diego start from $296 round-trip. Over the 2 Southwest flights for this route in a normal week, average airfare is usually $464 round-trip - but some users have found much cheaper deals with momondo.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
Coronado
El Cajon
Julian
National City
La Mesa
Poway
San Ysidro
Imperial Beach
Santee
Borrego Springs
Lemon Grove
Alpine

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Diego?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Diego from Des Moines.

Can I find flights from Des Moines to San Diego with flexible booking policies on momondo?

Flights from Des Moines to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Des Moines.

I’m not ready to book a flight from Des Moines to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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