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Cheap flights from Des Moines to San Diego from $113

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:31 pm - 7:55 amDSM  Des Moines-SAN San Diego
12h 24m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
11:16 am - 7:40 pmSAN  San Diego-DSM Des Moines
6h 24m1 stop Denver Intl
$247Multiple Airlines
Mon, Nov 23 - Thu, Dec 3
Multiple Airlines Logo
7:30 am - 2:38 pmDSM  Des Moines-SAN San Diego
9h 08m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
6:36 am - 7:31 pmSAN  San Diego-DSM Des Moines
10h 55m1 stop Denver Intl
$252Multiple Airlines
Mon, Feb 1 - Thu, Feb 4
Frontier Logo
8:26 pm - 11:58 pmDSM  Des Moines-SAN San Diego
5h 32m1 stop Denver Intl
Frontier Logo
6:36 am - 7:31 pmSAN  San Diego-DSM Des Moines
10h 55m1 stop Denver Intl
$255Frontier
Thu, Dec 17 - Sun, Dec 20
Frontier Logo
8:26 pm - 4:31 pmDSM  Des Moines-SAN San Diego
22h 05m1 stop Denver Intl
Frontier Logo
6:36 am - 7:31 pmSAN  San Diego-DSM Des Moines
10h 55m1 stop Denver Intl
$259Frontier
Thu, Jan 28 - Sun, Jan 31
Southwest Logo
3:25 pm - 11:25 pmDSM  Des Moines-SAN San Diego
10h 00m1 stop Chicago Midway
Southwest Logo
6:30 am - 5:00 pmSAN  San Diego-DSM Des Moines
8h 30m1 stop Phoenix Sky Harbor Intl
$336Southwest
Tue, Dec 15 - Mon, Dec 21
Southwest Logo
7:00 am - 1:50 pmDSM  Des Moines-SAN San Diego
8h 50m2 stops Denver Intl San Jose
Southwest Logo
6:30 am - 5:00 pmSAN  San Diego-DSM Des Moines
8h 30m1 stop Phoenix Sky Harbor Intl
$341Southwest
Tue, Dec 15 - Mon, Dec 21
American Airlines Logo
5:00 am - 8:40 amDSM  Des Moines-SAN San Diego
5h 40m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
10:33 pm - 8:51 amSAN  San Diego-DSM Des Moines
8h 18m1 stop Chicago O'Hare Intl
$355American Airlines
Fri, Dec 18 - Wed, Dec 23
American Airlines Logo
3:25 pm - 8:43 pmDSM  Des Moines-SAN San Diego
7h 18m1 stop Dallas/Fort Worth
American Airlines Logo
12:29 pm - 11:30 pmSAN  San Diego-DSM Des Moines
9h 01m1 stop Dallas/Fort Worth
$355American Airlines
Tue, Dec 1 - Tue, Dec 8
Delta Logo
6:45 am - 1:36 pmDSM  Des Moines-SAN San Diego
8h 51m1 stop Minneapolis St Paul
Delta Logo
6:15 am - 4:07 pmSAN  San Diego-DSM Des Moines
7h 52m1 stop Minneapolis St Paul
$355Delta
Sat, Jan 30 - Sat, Feb 6
Delta Logo
6:45 am - 1:36 pmDSM  Des Moines-SAN San Diego
8h 51m1 stop Minneapolis St Paul
Delta Logo
6:15 am - 4:07 pmSAN  San Diego-DSM Des Moines
7h 52m1 stop Minneapolis St Paul
$355Delta
Tue, Feb 2 - Mon, Feb 8

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Frontier flights from Des Moines to San Diego

Our best Frontier deals on Des Moines to San Diego flight tickets
Frontier
Dec 17
DSM8:26 pmDes Moines
5h 32m
1 stop
SAN11:58 pmSan Diego
Dec 20
SAN6:36 amSan Diego
10h 55m
1 stop
DSM7:31 pmDes Moines
$255
Frontier
Jan 28
DSM8:26 pmDes Moines
22h 05m
1 stop
SAN4:31 pmSan Diego
Jan 31
SAN6:36 amSan Diego
10h 55m
1 stop
DSM7:31 pmDes Moines
$259
Frontier
Feb 11
DSM8:26 pmDes Moines
5h 32m
1 stop
SAN11:58 pmSan Diego
Feb 14
SAN6:36 amSan Diego
10h 55m
1 stop
DSM7:31 pmDes Moines
$270

American Airlines flights from Des Moines to San Diego

Our best American Airlines deals on Des Moines to San Diego flight tickets
American Airlines
Dec 21
DSM5:00 amDes Moines
8h 33m
1 stop
SAN11:33 amSan Diego
Dec 25
SAN6:15 amSan Diego
5h 29m
1 stop
DSM1:44 pmDes Moines
$355
American Airlines
Dec 18
DSM5:00 amDes Moines
5h 40m
1 stop
SAN8:40 amSan Diego
Dec 25
SAN6:15 amSan Diego
7h 16m
1 stop
DSM3:31 pmDes Moines
$356
American Airlines
Dec 18
DSM5:00 amDes Moines
5h 40m
1 stop
SAN8:40 amSan Diego
Dec 25
SAN1:15 pmSan Diego
7h 53m
1 stop
DSM11:08 pmDes Moines
$357

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Mon 11/23

9:31 pm-7:55 am

1 stop12h 24m

San Diego

Thu 12/3

11:16 am-7:40 pm

1 stop6h 24m

$247

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Mon 2/1

7:30 am-2:38 pm

1 stop9h 08m

San Diego

Thu 2/4

6:36 am-7:31 pm

1 stop10h 55m

$252

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Thu 12/17

8:26 pm-11:58 pm

1 stop5h 32m

San Diego

Sun 12/20

6:36 am-7:31 pm

1 stop10h 55m

$255

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Thu 1/28

8:26 pm-4:31 pm

1 stop22h 05m

San Diego

Sun 1/31

6:36 am-7:31 pm

1 stop10h 55m

$259

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Tue 12/15

3:25 pm-11:25 pm

1 stop10h 00m

San Diego

Mon 12/21

6:30 am-5:00 pm

1 stop8h 30m

$336

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Tue 12/15

7:00 am-1:50 pm

2 stops8h 50m

San Diego

Mon 12/21

6:30 am-5:00 pm

1 stop8h 30m

$341
Quickest round-trip

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Fri 12/18

5:00 am-8:40 am

1 stop5h 40m

San Diego

Wed 12/23

10:33 pm-8:51 am

1 stop8h 18m

$355

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Tue 12/1

3:25 pm-8:43 pm

1 stop7h 18m

San Diego

Tue 12/8

12:29 pm-11:30 pm

1 stop9h 01m

$355

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Sat 1/30

6:45 am-1:36 pm

1 stop8h 51m

San Diego

Sat 2/6

6:15 am-4:07 pm

1 stop7h 52m

$355

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Tue 2/2

6:45 am-1:36 pm

1 stop8h 51m

San Diego

Mon 2/8

6:15 am-4:07 pm

1 stop7h 52m

$355

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Des Moines to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Diego?

Prices are currently low for flights on this route.

Typical prices usually range from $376 to $546.
The lowest price recently found on this route was $255.

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of April, then departing from Des Moines during the month May is also very affordable. Most momondo users find prices during this month for around $371.

How far in advance should I book a flight from Des Moines to San Diego?

You are more likely to see cheaper flights to San Diego from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $427 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Des Moines for as low as $366 on momondo.

How have Des Moines to San Diego flight prices changed over time?

As of November 2026, prices for Des Moines to San Diego flights are approximately 22% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Diego (DSM to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Diego

Best Price Found

$113

Fastest flight time

5h 15m

Direct flights

None
The best one-way flight to San Diego from Des Moines in the past 72 hours is $113. The best round-trip flight deal from Des Moines to San Diego found on momondo in the last 72 hours is $247.
The fastest flight from Des Moines to San Diego takes 5h 15m
There are no direct flights from Des Moines to San Diego. There are no popular flight routes from Des Moines to San Diego.
Search flight deals

Frequently asked questions about flying from Des Moines to San Diego

  • How far is Des Moines to San Diego by plane?

    Des Moines and San Diego are 1426.2 mi apart from one another. In terms of flight time, this usually takes a little over 5h 15m.

  • When did momondo last update prices for flights from Des Moines Airport to San Diego Airport?

    Prices for flights from Des Moines Airport to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to San Diego Airport?

  • How old do you have to be to fly from Des Moines Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to San Diego?

  • What is the most popular airline from Des Moines to San Diego?

Best airlines flying from Des Moines to San Diego

Compare and see reviews for airlines that fly from Des Moines to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $116Free CancellationRating
5.5
2,513 reviews
Search Frontier flights
DeltaPriceFrom $148Free CancellationRating
7.8
8,696 reviews
Search Delta flights
American AirlinesPriceFrom $272Free CancellationRating
7.0
12,230 reviews
Search American Airlines flights
SouthwestPriceFrom $296Free CancellationRating
8.0
4,215 reviews
Search Southwest flights
United AirlinesPriceFrom $336Free CancellationRating
7.3
10,460 reviews
Search United Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
El Cajon
Coronado
National City
La Mesa
Julian
San Ysidro
Poway
Santee
Alpine
Imperial Beach
Lemon Grove
Borrego Springs

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Diego?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Diego from Des Moines.

Can I find flights from Des Moines to San Diego with flexible booking policies on momondo?

Flights from Des Moines to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Des Moines.

I’m not ready to book a flight from Des Moines to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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