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Cheap flights from Des Moines to San Diego from $101

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Diego departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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Frontier Logo
7:58 pm - 11:59 pmDSM-SAN
6h 01m1 stop
Frontier Logo
6:34 am - 7:03 pmSAN-DSM
10h 29m1 stop
$122Frontier
Find Deal
Mon, Dec 8 - Fri, Dec 12
Frontier Logo
7:58 pm - 11:59 pmDSM-SAN
6h 01m1 stop
Frontier Logo
6:34 am - 7:03 pmSAN-DSM
10h 29m1 stop
$124Frontier
Find Deal
Mon, Dec 8 - Fri, Dec 12
Frontier Logo
2:35 pm - 11:59 pmDSM-SAN
11h 24m1 stop
Frontier Logo
1:06 pm - 7:44 pmSAN-DSM
28h 38m2 stops
$132Frontier
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Tue, Dec 23 - Sun, Dec 28
American Airlines Logo
5:51 pm - 10:50 pmDSM-SAN
6h 59m1 stop
American Airlines Logo
7:10 am - 5:06 pmSAN-DSM
7h 56m1 stop
$290American Airlines
Find Deal
Tue, Jan 20 - Sat, Jan 24
American Airlines Logo
5:10 am - 8:47 amDSM-SAN
5h 37m1 stop
American Airlines Logo
6:15 am - 4:55 pmSAN-DSM
8h 40m1 stop
$297American Airlines
Find Deal
Tue, Dec 2 - Sat, Dec 13
Delta Logo
6:50 am - 1:09 pmDSM-SAN
8h 19m1 stop
Delta Logo
11:52 am - 8:02 pmSAN-DSM
6h 10m1 stop
$300Delta
Find Deal
Tue, Dec 16 - Thu, Dec 25
Delta Logo
4:59 pm - 11:44 pmDSM-SAN
8h 45m1 stop
Delta Logo
10:00 pm - 9:40 amSAN-DSM
9h 40m1 stop
$301Delta
Find Deal
Thu, Dec 4 - Sat, Dec 13
Southwest Logo
6:10 am - 1:10 pmDSM-SAN
9h 00m1 stop
Southwest Logo
2:20 pm - 9:15 pmSAN-DSM
4h 55m1 stop
$305Southwest
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Tue, Jan 20 - Sat, Jan 24
United Airlines Logo
1:35 pm - 7:54 pmDSM-SAN
8h 19m2 stops
United Airlines Logo
11:08 am - 8:34 pmSAN-DSM
7h 26m2 stops
$307United Airlines
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Wed, Feb 4 - Sat, Feb 7
United Airlines Logo
3:00 pm - 9:56 pmDSM-SAN
8h 56m1 stop
United Airlines Logo
4:10 pm - 11:58 pmSAN-DSM
5h 48m1 stop
$314United Airlines
Find Deal
Wed, Dec 24 - Wed, Dec 31

Frontier flights from Des Moines to San Diego

Our best Frontier deals on Des Moines to San Diego flight tickets
Frontier
Dec 8
DSM7:58 pmDes Moines
6h 01m
1 stop
SAN11:59 pmSan Diego
Dec 12
SAN6:34 amSan Diego
10h 29m
1 stop
DSM7:03 pmDes Moines
$122
Find similar
Frontier
Dec 8
DSM7:58 pmDes Moines
6h 01m
1 stop
SAN11:59 pmSan Diego
Dec 12
SAN6:34 amSan Diego
10h 29m
1 stop
DSM7:03 pmDes Moines
$124
Find similar
Frontier
Dec 23
DSM2:35 pmDes Moines
11h 24m
1 stop
SAN11:59 pmSan Diego
Dec 28
SAN1:06 pmSan Diego
28h 38m
2 stops
DSM7:44 pmDes Moines
$132
Find similar

American Airlines flights from Des Moines to San Diego

Our best American Airlines deals on Des Moines to San Diego flight tickets
American Airlines
Jan 20
DSM5:51 pmDes Moines
6h 59m
1 stop
SAN10:50 pmSan Diego
Jan 24
SAN7:10 amSan Diego
7h 56m
1 stop
DSM5:06 pmDes Moines
$290
Find similar
American Airlines
Dec 2
DSM5:10 amDes Moines
5h 37m
1 stop
SAN8:47 amSan Diego
Dec 13
SAN6:15 amSan Diego
8h 40m
1 stop
DSM4:55 pmDes Moines
$297
Find similar
American Airlines
Jan 15
DSM5:01 pmDes Moines
7h 25m
1 stop
SAN10:26 pmSan Diego
Jan 20
SAN9:21 amSan Diego
5h 45m
1 stop
DSM5:06 pmDes Moines
$313
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 12/8

7:58 pm-11:59 pm

1 stop6h 01m

San Diego

Fri 12/12

6:34 am-7:03 pm

1 stop10h 29m

$122

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 12/8

7:58 pm-11:59 pm

1 stop6h 01m

San Diego

Fri 12/12

6:34 am-7:03 pm

1 stop10h 29m

$124

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 12/23

2:35 pm-11:59 pm

1 stop11h 24m

San Diego

Sun 12/28

1:06 pm-7:44 pm

2 stops28h 38m

$132

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 1/20

5:51 pm-10:50 pm

1 stop6h 59m

San Diego

Sat 1/24

7:10 am-5:06 pm

1 stop7h 56m

$290

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 12/2

5:10 am-8:47 am

1 stop5h 37m

San Diego

Sat 12/13

6:15 am-4:55 pm

1 stop8h 40m

$297

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 12/16

6:50 am-1:09 pm

1 stop8h 19m

San Diego

Thu 12/25

11:52 am-8:02 pm

1 stop6h 10m

$300

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Thu 12/4

4:59 pm-11:44 pm

1 stop8h 45m

San Diego

Sat 12/13

10:00 pm-9:40 am

1 stop9h 40m

$301

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 1/20

6:10 am-1:10 pm

1 stop9h 00m

San Diego

Sat 1/24

2:20 pm-9:15 pm

1 stop4h 55m

$305

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 2/4

1:35 pm-7:54 pm

2 stops8h 19m

San Diego

Sat 2/7

11:08 am-8:34 pm

2 stops7h 26m

$307

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 12/24

3:00 pm-9:56 pm

1 stop8h 56m

San Diego

Wed 12/31

4:10 pm-11:58 pm

1 stop5h 48m

$314

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Des Moines to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of June, then departing from Des Moines during the month August is also very affordable. Most momondo users find prices during this month for around $282.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Des Moines to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $161. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $468. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $170. Flights in the morning are often more expensive with an average ticket price of $433.

What is the cheapest Des Moines to San Diego flight route?

Fly from Des Moines to San Diego for the best Des Moines - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $372 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Des Moines for as low as $264 on momondo.

What cabin class options are available on Des Moines to San Diego flights?

There is only 1 cabin class available to choose from on Des Moines to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to San Diego flights?

No. A direct flight is the cheapest option for a flight between Des Moines to San Diego.

How have Des Moines to San Diego flight prices changed over time?

As of October 2025, prices for Des Moines to San Diego flights are approximately 5% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Diego (DSM to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Diego

Direct flights

None
There are no direct flights from Des Moines to San Diego. There are no popular flight routes from Des Moines to San Diego.
Search flight deals

  • How far is Des Moines to San Diego by plane?

    Des Moines and San Diego are 1426.2 mi apart from one another. In terms of flight time, this usually takes a little over 5h 37m.

  • When did momondo last update prices for flights from Des Moines Airport to San Diego Airport?

    Prices for flights from Des Moines Airport to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to San Diego Airport?

  • How old do you have to be to fly from Des Moines Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to San Diego?

  • What is the most popular airline from Des Moines to San Diego?

Best airlines flying from Des Moines to San Diego

Compare and see reviews for airlines that fly from Des Moines to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $104Free CancellationRating
7.2
695 reviews
Search Allegiant Air flights
FrontierPriceFrom $125Free CancellationRating
5.8
3,123 reviews
Search Frontier flights
DeltaPriceFrom $270Free CancellationRating
7.9
7,993 reviews
Search Delta flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
11,030 reviews
Search American Airlines flights
SouthwestPriceFrom $333Free CancellationRating
8.0
4,242 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
La Mesa
Imperial Beach
Poway
Borrego Springs
San Ysidro
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Diego?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Diego from Des Moines.

Can I find flights from Des Moines to San Diego with flexible booking policies on momondo?

Flights from Des Moines to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Des Moines.

I’m not ready to book a flight from Des Moines to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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