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Cheap flights from Des Moines to San Diego from $126

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:25 pm - 3:58 pmDSM  Des Moines-SAN San Diego
21h 33m1 stop Denver Intl
Frontier Logo
6:25 am - 7:30 pmSAN  San Diego-DSM Des Moines
11h 05m1 stop Denver Intl
$241Frontier
Fri, Oct 23 - Mon, Oct 26
Frontier Logo
8:30 pm - 11:57 pmDSM  Des Moines-SAN San Diego
5h 27m1 stop Denver Intl
Frontier Logo
6:25 am - 7:35 pmSAN  San Diego-DSM Des Moines
11h 10m1 stop Denver Intl
$243Frontier
Fri, Oct 30 - Mon, Nov 2
Southwest Logo
2:30 pm - 6:25 pmDSM  Des Moines-SAN San Diego
5h 55m1 stop Las Vegas Harry Reid Intl
Southwest Logo
6:35 am - 2:15 pmSAN  San Diego-DSM Des Moines
5h 40m1 stop Denver Intl
$257Southwest
Sat, Nov 14 - Tue, Nov 17
Southwest Logo
12:15 pm - 4:55 pmDSM  Des Moines-SAN San Diego
6h 40m1 stop Las Vegas Harry Reid Intl
Southwest Logo
6:55 am - 1:55 pmSAN  San Diego-DSM Des Moines
5h 00m1 stop Denver Intl
$258Southwest
Wed, Jan 20 - Wed, Feb 10
Multiple Airlines Logo
8:30 pm - 11:57 pmDSM  Des Moines-SAN San Diego
29h 27m1 stop Denver Intl
Multiple Airlines Logo
10:56 am - 1:55 pmSAN  San Diego-DSM Des Moines
24h 59m2 stops San Francisco Las Vegas Harry Reid Intl
$279Multiple Airlines
Fri, Nov 6 - Tue, Nov 10
Multiple Airlines Logo
9:39 pm - 6:10 pmDSM  Des Moines-SAN San Diego
22h 31m2 stops Las Vegas Harry Reid Intl Oakland
Multiple Airlines Logo
8:17 am - 8:28 pmSAN  San Diego-DSM Des Moines
10h 11m1 stop Las Vegas Harry Reid Intl
$280Multiple Airlines
Mon, Nov 30 - Fri, Dec 4
American Airlines Logo
7:12 am - 12:42 pmDSM  Des Moines-SAN San Diego
7h 30m1 stop Chicago O'Hare Intl
American Airlines Logo
7:15 am - 5:34 pmSAN  San Diego-DSM Des Moines
8h 19m1 stop Dallas/Fort Worth
$291American Airlines
Wed, Jan 20 - Sat, Jan 23
Delta Logo
3:46 pm - 8:12 pmDSM  Des Moines-SAN San Diego
6h 26m1 stop Minneapolis St Paul
Delta Logo
6:25 am - 2:25 pmSAN  San Diego-DSM Des Moines
6h 00m1 stop Minneapolis St Paul
$291Delta
Wed, Oct 28 - Sat, Oct 31
Delta Logo
7:51 pm - 11:48 pmDSM  Des Moines-SAN San Diego
5h 57m1 stop Minneapolis St Paul
Delta Logo
12:00 pm - 9:00 pmSAN  San Diego-DSM Des Moines
7h 00m1 stop Minneapolis St Paul
$292Delta
Mon, Oct 26 - Wed, Oct 28
American Airlines Logo
1:58 pm - 7:15 pmDSM  Des Moines-SAN San Diego
7h 17m1 stop Chicago O'Hare Intl
American Airlines Logo
1:29 pm - 12:26 amSAN  San Diego-DSM Des Moines
8h 57m1 stop Chicago O'Hare Intl
$321American Airlines
Wed, Dec 9 - Mon, Dec 14

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Alaska Airlines flights from Des Moines to San Diego

Our best Alaska Airlines deals on Des Moines to San Diego flight tickets
Alaska Airlines
Oct 2
DSM2:29 pmDes Moines
21h 37m
2 stops
SAN10:06 amSan Diego
Oct 4
SAN6:15 amSan Diego
11h 06m
2 stops
DSM7:21 pmDes Moines
$693
Alaska Airlines
Oct 1
DSM5:30 amDes Moines
13h 43m
2 stops
SAN5:13 pmSan Diego
Oct 4
SAN6:15 amSan Diego
11h 06m
2 stops
DSM7:21 pmDes Moines
$813
Alaska Airlines
Sep 29
DSM5:30 amDes Moines
13h 43m
2 stops
SAN5:13 pmSan Diego
Oct 4
SAN6:15 amSan Diego
11h 06m
2 stops
DSM7:21 pmDes Moines
$837

Delta flights from Des Moines to San Diego

Our best Delta deals on Des Moines to San Diego flight tickets
Delta
Oct 19
DSM7:51 pmDes Moines
5h 57m
1 stop
SAN11:48 pmSan Diego
Oct 21
SAN6:25 amSan Diego
6h 00m
1 stop
DSM2:25 pmDes Moines
$275
Delta
Oct 28
DSM3:46 pmDes Moines
6h 26m
1 stop
SAN8:12 pmSan Diego
Oct 31
SAN6:25 amSan Diego
6h 00m
1 stop
DSM2:25 pmDes Moines
$291
Delta
Oct 29
DSM6:55 amDes Moines
5h 53m
1 stop
SAN10:48 amSan Diego
Oct 31
SAN6:25 amSan Diego
6h 00m
1 stop
DSM2:25 pmDes Moines
$292

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.

Fly from

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Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Fri 10/23

8:25 pm-3:58 pm

1 stop21h 33m

San Diego

Mon 10/26

6:25 am-7:30 pm

1 stop11h 05m

$241

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Fri 10/30

8:30 pm-11:57 pm

1 stop5h 27m

San Diego

Mon 11/2

6:25 am-7:35 pm

1 stop11h 10m

$243
Quickest round-trip

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Sat 11/14

2:30 pm-6:25 pm

1 stop5h 55m

San Diego

Tue 11/17

6:35 am-2:15 pm

1 stop5h 40m

$257

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Wed 1/20

12:15 pm-4:55 pm

1 stop6h 40m

San Diego

Wed 2/10

6:55 am-1:55 pm

1 stop5h 00m

$258

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Fri 11/6

8:30 pm-11:57 pm

1 stop29h 27m

San Diego

Tue 11/10

10:56 am-1:55 pm

2 stops24h 59m

$279

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Mon 11/30

9:39 pm-6:10 pm

2 stops22h 31m

San Diego

Fri 12/4

8:17 am-8:28 pm

1 stop10h 11m

$280

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Wed 1/20

7:12 am-12:42 pm

1 stop7h 30m

San Diego

Sat 1/23

7:15 am-5:34 pm

1 stop8h 19m

$291

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Wed 10/28

3:46 pm-8:12 pm

1 stop6h 26m

San Diego

Sat 10/31

6:25 am-2:25 pm

1 stop6h 00m

$291

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Mon 10/26

7:51 pm-11:48 pm

1 stop5h 57m

San Diego

Wed 10/28

12:00 pm-9:00 pm

1 stop7h 00m

$292

Des MoinesSan Diego

DSM Des Moines - SAN San Diego

DSMSAN

Des Moines

Wed 12/9

1:58 pm-7:15 pm

1 stop7h 17m

San Diego

Mon 12/14

1:29 pm-12:26 am

1 stop8h 57m

$321

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Des Moines to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and San Diego?

Prices are currently low for flights on this route.

Typical prices usually range from $297 to $488.
The lowest price recently found on this route was $241.

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Des Moines during the month April is also very affordable. Most momondo users find prices during this month for around $362.

What is the cheapest Des Moines to San Diego flight route?

Fly from Des Moines to San Diego for the best Des Moines - San Diego flight prices

How far in advance should I book a flight from Des Moines to San Diego?

You are more likely to see cheaper flights to San Diego from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $425 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Des Moines for as low as $366 on momondo.

What cabin class options are available on Des Moines to San Diego flights?

There is only 1 cabin class available to choose from on Des Moines to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Des Moines to San Diego flight prices changed over time?

As of September 2026, prices for Des Moines to San Diego flights are approximately 23% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Diego (DSM to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Diego

Best Price Found

$126

Fastest flight time

5h 25m

Direct flights

None
The best one-way flight to San Diego from Des Moines in the past 72 hours is $126. The best round-trip flight deal from Des Moines to San Diego found on momondo in the last 72 hours is $241.
The fastest flight from Des Moines to San Diego takes 5h 25m
There are no direct flights from Des Moines to San Diego. There are no popular flight routes from Des Moines to San Diego.
Search flight deals

Frequently asked questions about flying from Des Moines to San Diego

  • How far is Des Moines to San Diego by plane?

    Des Moines and San Diego are 1426.2 mi apart from one another. In terms of flight time, this usually takes a little over 5h 25m.

  • When did momondo last update prices for flights from Des Moines Airport to San Diego Airport?

    Prices for flights from Des Moines Airport to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to San Diego Airport?

  • How old do you have to be to fly from Des Moines Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to San Diego?

  • What is the most popular airline from Des Moines to San Diego?

Best airlines flying from Des Moines to San Diego

Compare and see reviews for airlines that fly from Des Moines to San Diego with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $116Free CancellationRating
5.6
2,587 reviews
Search Frontier flights
DeltaPriceFrom $148Free CancellationRating
7.8
8,590 reviews
Search Delta flights
American AirlinesPriceFrom $272Free CancellationRating
7.0
12,072 reviews
Search American Airlines flights
SouthwestPriceFrom $296Free CancellationRating
8.0
4,193 reviews
Search Southwest flights
United AirlinesPriceFrom $320Free CancellationRating
7.4
10,220 reviews
Search United Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
El Cajon
Coronado
National City
La Mesa
Julian
Poway
San Ysidro
Imperial Beach
Santee
Alpine
Lemon Grove
Borrego Springs

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Diego?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Diego from Des Moines.

Can I find flights from Des Moines to San Diego with flexible booking policies on momondo?

Flights from Des Moines to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Des Moines.

I’m not ready to book a flight from Des Moines to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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