Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to San Diego from $101

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Diego departing on 10/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Des Moines to San Diego

Cheap round-trip flights

Logo
3:42 pm - 11:34 pmDSM-SAN
9h 52m1 stop
Logo
6:15 am - 10:29 pmSAN-DSM
14h 14m1 stop
$214
Find Deal
Sun, Sep 7 - Fri, Sep 12
Logo
2:54 pm - 4:30 pmDSM-SAN
3h 36mnonstop
Logo
6:25 am - 6:48 pmSAN-DSM
10h 23m1 stop
$215
Find Deal
Fri, Aug 15 - Mon, Aug 18
Logo
3:30 pm - 10:26 pmDSM-SAN
8h 56m1 stop
Logo
6:15 am - 10:29 pmSAN-DSM
14h 14m1 stop
$221
Find Deal
Mon, Sep 15 - Mon, Sep 22
Frontier Logo
8:44 pm - 11:50 pmDSM-SAN
5h 06m1 stop
Frontier Logo
6:25 am - 2:43 pmSAN-DSM
6h 18m1 stop
$224Frontier
Find Deal
Mon, Oct 13 - Wed, Oct 15
Frontier Logo
8:44 pm - 11:50 pmDSM-SAN
5h 06m1 stop
Frontier Logo
4:16 pm - 7:59 pmSAN-DSM
25h 43m1 stop
$235Frontier
Find Deal
Thu, Nov 6 - Sat, Nov 8
Allegiant Air Logo
2:54 pm - 4:30 pmDSM-SAN
3h 36mnonstop
Allegiant Air Logo
5:20 pm - 10:44 pmSAN-DSM
3h 24mnonstop
$261Allegiant Air
Find Deal
Fri, Aug 15 - Mon, Aug 18
American Airlines Logo
5:10 am - 9:52 amDSM-SAN
6h 42m1 stop
American Airlines Logo
4:40 pm - 12:18 amSAN-DSM
5h 38m1 stop
$287American Airlines
Find Deal
Wed, Sep 3 - Wed, Sep 3
United Airlines Logo
6:00 am - 9:09 amDSM-SAN
5h 09m1 stop
United Airlines Logo
2:21 pm - 11:41 pmSAN-DSM
7h 20m2 stops
$292United Airlines
Find Deal
Wed, Sep 3 - Wed, Sep 3
American Airlines Logo
5:10 am - 3:19 pmDSM-SAN
12h 09m1 stop
American Airlines Logo
7:10 am - 4:14 pmSAN-DSM
7h 04m1 stop
$312American Airlines
Find Deal
Tue, Dec 2 - Sat, Dec 13
Southwest Logo
8:20 am - 12:40 pmDSM-SAN
6h 20m1 stop
Southwest Logo
10:55 am - 9:00 pmSAN-DSM
8h 05m2 stops
$332Southwest
Find Deal
Tue, Nov 11 - Thu, Nov 13

American Airlines flights from Des Moines to San Diego

Our best American Airlines deals on Des Moines to San Diego flight tickets
American Airlines
Sep 3
DSM5:10 amDes Moines
6h 42m
1 stop
SAN9:52 amSan Diego
Sep 3
SAN4:40 pmSan Diego
5h 38m
1 stop
DSM12:18 amDes Moines
$287
Find similar
American Airlines
Dec 2
DSM5:10 amDes Moines
12h 09m
1 stop
SAN3:19 pmSan Diego
Dec 13
SAN7:10 amSan Diego
7h 04m
1 stop
DSM4:14 pmDes Moines
$312
Find similar
American Airlines
Aug 20
DSM7:32 amDes Moines
6h 43m
1 stop
SAN12:15 pmSan Diego
Aug 21
SAN12:50 pmSan Diego
8h 55m
1 stop
DSM11:45 pmDes Moines
$352
Find similar

United Airlines flights from Des Moines to San Diego

Our best United Airlines deals on Des Moines to San Diego flight tickets
United Airlines
Sep 3
DSM6:00 amDes Moines
5h 09m
1 stop
SAN9:09 amSan Diego
Sep 3
SAN2:21 pmSan Diego
7h 20m
2 stops
DSM11:41 pmDes Moines
$292
Find similar
United Airlines
Aug 15
DSM5:12 pmDes Moines
9h 03m
2 stops
SAN12:15 amSan Diego
Aug 17
SAN8:44 pmSan Diego
11h 45m
2 stops
DSM10:29 amDes Moines
$547
Find similar
United Airlines
Aug 13
DSM8:00 amDes Moines
28h 12m
2 stops
SAN10:12 amSan Diego
Aug 17
SAN8:44 pmSan Diego
11h 45m
2 stops
DSM10:29 amDes Moines
$589
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 2, 2025.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Sun 9/7

3:42 pm-11:34 pm

1 stop9h 52m

San Diego

Fri 9/12

6:15 am-10:29 pm

1 stop14h 14m

$214

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Fri 8/15

2:54 pm-4:30 pm

Nonstop3h 36m

San Diego

Mon 8/18

6:25 am-6:48 pm

1 stop10h 23m

$215

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 9/15

3:30 pm-10:26 pm

1 stop8h 56m

San Diego

Mon 9/22

6:15 am-10:29 pm

1 stop14h 14m

$221

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 10/13

8:44 pm-11:50 pm

1 stop5h 06m

San Diego

Wed 10/15

6:25 am-2:43 pm

1 stop6h 18m

$224

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Thu 11/6

8:44 pm-11:50 pm

1 stop5h 06m

San Diego

Sat 11/8

4:16 pm-7:59 pm

1 stop25h 43m

$235

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Fri 8/15

2:54 pm-4:30 pm

Nonstop3h 36m

San Diego

Mon 8/18

5:20 pm-10:44 pm

Nonstop3h 24m

$261

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 9/3

5:10 am-9:52 am

1 stop6h 42m

San Diego

Wed 9/3

4:40 pm-12:18 am

1 stop5h 38m

$287

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 9/3

6:00 am-9:09 am

1 stop5h 09m

San Diego

Wed 9/3

2:21 pm-11:41 pm

2 stops7h 20m

$292

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 12/2

5:10 am-3:19 pm

1 stop12h 09m

San Diego

Sat 12/13

7:10 am-4:14 pm

1 stop7h 04m

$312

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 11/11

8:20 am-12:40 pm

1 stop6h 20m

San Diego

Thu 11/13

10:55 am-9:00 pm

2 stops8h 05m

$332

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Diego from

How to get the cheapest flight ticket from Des Moines to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of June, then departing from Des Moines during the month July is also very affordable. Most momondo users find prices during this month for around $292.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Des Moines to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $166. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $468. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $175. Flights in the morning are often more expensive with an average ticket price of $433.

What is the cheapest Des Moines to San Diego flight route?

Fly from Des Moines to San Diego for the best Des Moines - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $383 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Des Moines for as low as $273 on momondo.

What cabin class options are available on Des Moines to San Diego flights?

There are 1 cabin classes available to choose from on Des Moines to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Des Moines to San Diego flight prices changed over time?

As of August 2025, prices for Des Moines to San Diego flights are approximately 11% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to San Diego (DSM to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to San Diego

Best Price Found

$101

Fastest flight time

3h 31m

Direct flights

Sat

Airports in San Diego

1 airport
The best one-way flight to San Diego from Des Moines in the past 72 hours is $101. The best round-trip flight deal from Des Moines to San Diego found on momondo in the last 72 hours is $214.
The fastest flight from Des Moines to San Diego takes 3h 31m
Direct flights go from Des Moines to San Diego on Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport near San Diego: San Diego (SAN)
Search flight deals

  • How far is Des Moines to San Diego by plane?

    Des Moines and San Diego are 1426.2 mi apart from one another. In terms of flight time, this usually takes a little over 3h 36m.

  • When did momondo last update prices for flights from Des Moines Airport to San Diego Airport?

    Prices for flights from Des Moines Airport to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to San Diego Airport?

  • How old do you have to be to fly from Des Moines Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to San Diego?

  • What is the most popular airline from Des Moines to San Diego?

Best airlines flying from Des Moines to San Diego

Compare and see reviews for airlines that fly from Des Moines to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $116Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
FrontierPriceFrom $128Free CancellationRating
5.8
3,241 reviews
Search Frontier flights
DeltaPriceFrom $286Free CancellationRating
8.0
7,983 reviews
Search Delta flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $293Free CancellationRating
7.4
8,904 reviews
Search United Airlines flights
SouthwestPriceFrom $356Free CancellationRating
8.0
4,246 reviews
Search Southwest flights

  • Allegiant Air Flights From Des Moines to San Diego

    Allegiant Air flight deals from Des Moines to San Diego start from $116 round-trip. Over the 2 Allegiant Air flights for this route in a normal week, average airfare is usually $179 round-trip - but some users have found much cheaper deals with momondo.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
La Mesa
Imperial Beach
San Ysidro
Poway
Borrego Springs
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to San Diego?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to San Diego from Des Moines.

Can I find flights from Des Moines to San Diego with flexible booking policies on momondo?

Flights from Des Moines to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Des Moines.

I’m not ready to book a flight from Des Moines to San Diego right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to San Diego flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your San Diego trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 8/7
Thu 8/14
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States