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Cheap flights from Knoxville to Los Angeles from $182

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:30 am - 3:02 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
10h 32m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
3:57 pm - 11:14 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
28h 17m1 stop Las Vegas Harry Reid Intl
$339Multiple Airlines
Mon, Feb 8 - Thu, Feb 11
American Airlines Logo
5:19 pm - 10:32 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
8h 13m1 stop Charlotte Douglas
American Airlines Logo
1:20 pm - 11:40 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 20m1 stop Dallas/Fort Worth
$363American Airlines
Wed, Nov 18 - Wed, Dec 9
United Airlines Logo
6:45 am - 1:14 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
9h 29m2 stops Chicago O'Hare Intl Denver Intl
United Airlines Logo
10:20 am - 8:47 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 27m1 stop Chicago O'Hare Intl
$368United Airlines
Wed, Nov 18 - Wed, Dec 9
Multiple Airlines Logo
6:30 am - 10:46 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 16m1 stop Denver Intl
Multiple Airlines Logo
3:55 pm - 12:42 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
17h 47m1 stop Las Vegas Harry Reid Intl
$371Multiple Airlines
Thu, Nov 5 - Thu, Nov 19
United Airlines Logo
3:45 pm - 9:55 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
9h 10m1 stop Houston George Bush Intcntl
United Airlines Logo
6:50 am - 4:04 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 14m1 stop Denver Intl
$380United Airlines
Sat, Nov 7 - Fri, Nov 13
Southwest Logo
2:40 pm - 8:30 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
8h 50m2 stops Dallas Love Field Las Vegas Harry Reid Intl
Southwest Logo
7:00 am - 7:45 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
9h 45m2 stops Austin Bergstrom Nashville Intl
$390Southwest
Wed, Nov 18 - Wed, Dec 9
American Airlines Logo
5:30 am - 9:57 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 27m1 stop Dallas/Fort Worth
American Airlines Logo
12:10 pm - 11:19 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
8h 09m1 stop Dallas/Fort Worth
$415American Airlines
Thu, Dec 10 - Fri, Jan 15
Delta Logo
2:38 pm - 6:38 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 00m1 stop Atlanta Hartsfield-Jackson
Delta Logo
12:48 pm - 11:02 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 14m1 stop Minneapolis St Paul
$421Delta
Sat, Oct 31 - Mon, Nov 2
Southwest Logo
4:15 pm - 9:45 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
8h 30m1 stop Denver Intl
Southwest Logo
7:00 pm - 12:00 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
14h 00m2 stops Denver Intl Nashville Intl
$426Southwest
Thu, Dec 10 - Fri, Jan 15
Delta Logo
2:38 pm - 6:38 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 00m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:45 am - 5:28 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 43m1 stop Atlanta Hartsfield-Jackson
$473Delta
Sat, Oct 31 - Sun, Nov 8

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American Airlines flights from Knoxville to Santa Ana, California

Our best American Airlines deals on Knoxville to Santa Ana, California flight tickets
American Airlines
Nov 18
TYS5:19 pmKnoxville McGhee Tyson
8h 13m
1 stop
SNA10:32 pmSanta Ana J. Wayne/Orange Cnty
Dec 9
SNA1:20 pmSanta Ana J. Wayne/Orange Cnty
7h 20m
1 stop
TYS11:40 pmKnoxville McGhee Tyson
$363
American Airlines
Dec 10
TYS5:30 amKnoxville McGhee Tyson
7h 27m
1 stop
SNA9:57 amSanta Ana J. Wayne/Orange Cnty
Jan 15
SNA12:10 pmSanta Ana J. Wayne/Orange Cnty
8h 09m
1 stop
TYS11:19 pmKnoxville McGhee Tyson
$415
American Airlines
Oct 15
TYS6:00 amKnoxville McGhee Tyson
8h 00m
1 stop
SNA11:00 amSanta Ana J. Wayne/Orange Cnty
Oct 20
SNA1:26 pmSanta Ana J. Wayne/Orange Cnty
6h 52m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
$485

United Airlines flights from Knoxville to Santa Ana, California

Our best United Airlines deals on Knoxville to Santa Ana, California flight tickets
United Airlines
Nov 18
TYS6:45 amKnoxville McGhee Tyson
9h 29m
2 stops
SNA1:14 pmSanta Ana J. Wayne/Orange Cnty
Dec 9
SNA10:20 amSanta Ana J. Wayne/Orange Cnty
7h 27m
1 stop
TYS8:47 pmKnoxville McGhee Tyson
$368
United Airlines
Nov 3
TYS9:00 amKnoxville McGhee Tyson
8h 59m
1 stop
SNA2:59 pmSanta Ana J. Wayne/Orange Cnty
Nov 4
SNA1:09 pmSanta Ana J. Wayne/Orange Cnty
6h 23m
1 stop
TYS10:32 pmKnoxville McGhee Tyson
$483
United Airlines
Oct 31
TYS1:54 pmKnoxville McGhee Tyson
8h 07m
1 stop
SNA7:01 pmSanta Ana J. Wayne/Orange Cnty
Nov 5
SNA11:10 amSanta Ana J. Wayne/Orange Cnty
8h 22m
1 stop
TYS10:32 pmKnoxville McGhee Tyson
$486

momondo Fare Finder

 
Use the filters below to find and compare flights from Knoxville to Santa Ana, California that are best for you.

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Route

Depart

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Price

Cheapest round-trip

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Mon 2/8

7:30 am-3:02 pm

1 stop10h 32m

Santa Ana J. Wayne/Orange Cnty

Thu 2/11

3:57 pm-11:14 pm

1 stop28h 17m

$339

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Wed 11/18

5:19 pm-10:32 pm

1 stop8h 13m

Santa Ana J. Wayne/Orange Cnty

Wed 12/9

1:20 pm-11:40 pm

1 stop7h 20m

$363

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Wed 11/18

6:45 am-1:14 pm

2 stops9h 29m

Santa Ana J. Wayne/Orange Cnty

Wed 12/9

10:20 am-8:47 pm

1 stop7h 27m

$368

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Thu 11/5

6:30 am-10:46 am

1 stop7h 16m

Santa Ana J. Wayne/Orange Cnty

Thu 11/19

3:55 pm-12:42 pm

1 stop17h 47m

$371

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Sat 11/7

3:45 pm-9:55 pm

1 stop9h 10m

Santa Ana J. Wayne/Orange Cnty

Fri 11/13

6:50 am-4:04 pm

1 stop6h 14m

$380

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Wed 11/18

2:40 pm-8:30 pm

2 stops8h 50m

Santa Ana J. Wayne/Orange Cnty

Wed 12/9

7:00 am-7:45 pm

2 stops9h 45m

$390

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Thu 12/10

5:30 am-9:57 am

1 stop7h 27m

Santa Ana J. Wayne/Orange Cnty

Fri 1/15

12:10 pm-11:19 pm

1 stop8h 09m

$415

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Sat 10/31

2:38 pm-6:38 pm

1 stop7h 00m

Santa Ana J. Wayne/Orange Cnty

Mon 11/2

12:48 pm-11:02 pm

1 stop7h 14m

$421

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Thu 12/10

4:15 pm-9:45 pm

1 stop8h 30m

Santa Ana J. Wayne/Orange Cnty

Fri 1/15

7:00 pm-12:00 pm

2 stops14h 00m

$426
Quickest round-trip

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Sat 10/31

2:38 pm-6:38 pm

1 stop7h 00m

Santa Ana J. Wayne/Orange Cnty

Sun 11/8

7:45 am-5:28 pm

1 stop6h 43m

$473

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Santa Ana, California?

Prices are currently low for flights on this route.

Typical prices usually range from $494 to $749.
The lowest price recently found on this route was $339.

What is the cheapest month to fly to Santa Ana, California?

In general, May is the cheapest month to fly from Knoxville to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $448. If you aren’t able to travel during the month of May, then book flights to Santa Ana, California from Knoxville during August instead. Flights to Santa Ana, California in August, while not as cheap as those in May, still average around $456.

How have Knoxville to Santa Ana, California flight prices changed over time?

As of September 2026, prices for Knoxville to Santa Ana, California flights are approximately 55% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santa Ana, California (TYS to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santa Ana, California

Best Price Found

$182

Fastest flight time

6h 47m

Direct flights

None
The best one-way flight to Santa Ana, California from Knoxville in the past 72 hours is $182. The best round-trip flight deal from Knoxville to Santa Ana, California found on momondo in the last 72 hours is $339.
The fastest flight from Knoxville to Santa Ana, California takes 6h 47m
There are no direct flights from Knoxville to Santa Ana, California. There are no popular flight routes from Knoxville to Santa Ana, California.
Search flight deals

Frequently asked questions about flying from Knoxville to Santa Ana, California

  • How far is Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty by plane?

    Knoxville McGhee Tyson and Santa Ana J. Wayne/Orange Cnty are 1919.8 mi apart from one another. Typically, this will take 6h 47m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The required travel and health documents for your Santa Ana J. Wayne/Orange Cnty Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santa Ana, California?

Best airlines flying from Knoxville to Santa Ana, California

Compare and see reviews for airlines that fly from Knoxville to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $228Free CancellationRating
7.8
8,611 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
10,255 reviews
Search United Airlines flights
American AirlinesPriceFrom $338Free CancellationRating
7.0
12,095 reviews
Search American Airlines flights
SouthwestPriceFrom $378Free CancellationRating
8.0
4,201 reviews
Search Southwest flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
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Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Santa Ana for you.

Can I find flights from Knoxville to Santa Ana with flexible booking policies on momondo?

Flights from Knoxville to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Santa Ana?

momondo provides multiple filters to help you find the best flight to Santa Ana from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Santa Ana right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santa Ana flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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