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Cheap flights from Knoxville to Los Angeles from $108

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Los Angeles departing on 7/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:39 pm - 1:05 pm
TYS
-
SNA
25h 26m
1 stop
Multiple Airlines Logo
8:10 pm - 3:58 pm
SNA
-
TYS
16h 48m
1 stop
$301Multiple Airlines
Sun, Aug 23 - Sun, Aug 30
Multiple Airlines Logo
7:00 am - 12:00 pm
TYS
-
SNA
32h 00m
2 stops
Multiple Airlines Logo
8:10 pm - 3:58 pm
SNA
-
TYS
16h 48m
1 stop
$328Multiple Airlines
Sun, Aug 23 - Sun, Aug 30
Frontier Logo
8:19 pm - 9:09 am
TYS
-
SNA
15h 50m
1 stop
Frontier Logo
9:54 am - 7:33 pm
SNA
-
TYS
6h 39m
1 stop
$335Frontier
Fri, May 29 - Fri, Jun 5
Multiple Airlines Logo
7:00 am - 8:05 am
TYS
-
SNA
28h 05m
1 stop
Multiple Airlines Logo
4:08 pm - 11:37 pm
SNA
-
TYS
52h 29m
2 stops
$350Multiple Airlines
Sun, Jul 26 - Tue, Aug 11
Frontier Logo
8:19 pm - 9:09 am
TYS
-
SNA
15h 50m
1 stop
Frontier Logo
9:54 am - 7:24 pm
SNA
-
TYS
6h 30m
1 stop
$358Frontier
Fri, May 22 - Mon, May 25
American Airlines Logo
5:31 pm - 10:25 pm
TYS
-
SNA
7h 54m
1 stop
American Airlines Logo
12:55 pm - 11:52 pm
SNA
-
TYS
7h 57m
1 stop
$359American Airlines
Tue, Jul 28 - Tue, Aug 4
Southwest Logo
5:40 pm - 9:55 pm
TYS
-
SNA
7h 15m
1 stop
Southwest Logo
6:45 am - 6:55 pm
SNA
-
TYS
9h 10m
2 stops
$364Southwest
Tue, Jul 28 - Tue, Aug 4
Southwest Logo
7:10 am - 12:45 pm
TYS
-
SNA
8h 35m
2 stops
Southwest Logo
6:45 am - 6:55 pm
SNA
-
TYS
9h 10m
2 stops
$384Southwest
Tue, Jul 28 - Tue, Aug 4
Southwest Logo
4:50 pm - 9:55 pm
TYS
-
SNA
8h 05m
1 stop
Southwest Logo
6:45 am - 6:55 pm
SNA
-
TYS
9h 10m
2 stops
$404Southwest
Thu, Sep 17 - Tue, Sep 22
Southwest Logo
2:05 pm - 9:10 pm
TYS
-
SNA
10h 05m
2 stops
Southwest Logo
6:45 am - 6:55 pm
SNA
-
TYS
9h 10m
2 stops
$409Southwest
Thu, Sep 17 - Tue, Sep 22

Delta flights from Knoxville to Santa Ana, California

Our best Delta deals on Knoxville to Santa Ana, California flight tickets
Delta
May 12
TYS5:59 pmKnoxville McGhee Tyson
7h 30m
1 stop
SNA10:29 pmSanta Ana J. Wayne/Orange Cnty
Jun 24
SNA2:00 pmSanta Ana J. Wayne/Orange Cnty
6h 54m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
$454
Delta
Jun 3
TYS5:59 pmKnoxville McGhee Tyson
7h 30m
1 stop
SNA10:29 pmSanta Ana J. Wayne/Orange Cnty
Jun 10
SNA11:44 amSanta Ana J. Wayne/Orange Cnty
6h 57m
1 stop
TYS9:41 pmKnoxville McGhee Tyson
$471
Delta
Sep 17
TYS6:45 amKnoxville McGhee Tyson
9h 13m
1 stop
SNA12:58 pmSanta Ana J. Wayne/Orange Cnty
Sep 22
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
8h 32m
1 stop
TYS6:17 pmKnoxville McGhee Tyson
$482

United Airlines flights from Knoxville to Santa Ana, California

Our best United Airlines deals on Knoxville to Santa Ana, California flight tickets
United Airlines
Aug 29
TYS7:15 amKnoxville McGhee Tyson
9h 47m
1 stop
SNA2:02 pmSanta Ana J. Wayne/Orange Cnty
Sep 1
SNA12:04 pmSanta Ana J. Wayne/Orange Cnty
6h 26m
1 stop
TYS9:30 pmKnoxville McGhee Tyson
$449
United Airlines
Aug 29
TYS8:48 amKnoxville McGhee Tyson
7h 26m
1 stop
SNA1:14 pmSanta Ana J. Wayne/Orange Cnty
Sep 1
SNA6:50 amSanta Ana J. Wayne/Orange Cnty
14h 07m
2 stops
TYS11:57 pmKnoxville McGhee Tyson
$454
United Airlines
May 28
TYS4:56 pmKnoxville McGhee Tyson
8h 05m
1 stop
SNA10:01 pmSanta Ana J. Wayne/Orange Cnty
Jun 3
SNA10:20 amSanta Ana J. Wayne/Orange Cnty
8h 59m
1 stop
TYS10:19 pmKnoxville McGhee Tyson
$467

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 8/23

2:39 pm-1:05 pm

1 stop25h 26m

Santa Ana J. Wayne/Orange Cnty

Sun 8/30

8:10 pm-3:58 pm

1 stop16h 48m

$301

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 8/23

7:00 am-12:00 pm

2 stops32h 00m

Santa Ana J. Wayne/Orange Cnty

Sun 8/30

8:10 pm-3:58 pm

1 stop16h 48m

$328

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 5/29

8:19 pm-9:09 am

1 stop15h 50m

Santa Ana J. Wayne/Orange Cnty

Fri 6/5

9:54 am-7:33 pm

1 stop6h 39m

$335

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 7/26

7:00 am-8:05 am

1 stop28h 05m

Santa Ana J. Wayne/Orange Cnty

Tue 8/11

4:08 pm-11:37 pm

2 stops52h 29m

$350

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 5/22

8:19 pm-9:09 am

1 stop15h 50m

Santa Ana J. Wayne/Orange Cnty

Mon 5/25

9:54 am-7:24 pm

1 stop6h 30m

$358
Quickest round-trip

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 7/28

5:31 pm-10:25 pm

1 stop7h 54m

Santa Ana J. Wayne/Orange Cnty

Tue 8/4

12:55 pm-11:52 pm

1 stop7h 57m

$359

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 7/28

5:40 pm-9:55 pm

1 stop7h 15m

Santa Ana J. Wayne/Orange Cnty

Tue 8/4

6:45 am-6:55 pm

2 stops9h 10m

$364

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 7/28

7:10 am-12:45 pm

2 stops8h 35m

Santa Ana J. Wayne/Orange Cnty

Tue 8/4

6:45 am-6:55 pm

2 stops9h 10m

$384

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 9/17

4:50 pm-9:55 pm

1 stop8h 05m

Santa Ana J. Wayne/Orange Cnty

Tue 9/22

6:45 am-6:55 pm

2 stops9h 10m

$404

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 9/17

2:05 pm-9:10 pm

2 stops10h 05m

Santa Ana J. Wayne/Orange Cnty

Tue 9/22

6:45 am-6:55 pm

2 stops9h 10m

$409

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Santa Ana, California?

What is the cheapest month to fly to Santa Ana, California?

In general, May is the cheapest month to fly from Knoxville to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $338. If you aren’t able to travel during the month of May, then book flights to Santa Ana, California from Knoxville during September instead. Flights to Santa Ana, California in September, while not as cheap as those in May, still average around $378.

How far in advance should I book a flight from Knoxville to Santa Ana, California?

You are more likely to see cheaper flights to Santa Ana, California from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $501 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from Knoxville for as low as $288 on momondo.

How have Knoxville to Santa Ana, California flight prices changed over time?

As of May 2026, prices for Knoxville to Santa Ana, California flights are approximately 210% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santa Ana, California (TYS to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santa Ana, California

Fastest flight time

6h 44m

Direct flights

None
The fastest flight from Knoxville to Santa Ana, California takes 6h 44m
There are no direct flights from Knoxville to Santa Ana, California. There are no popular flight routes from Knoxville to Santa Ana, California.
Search flight deals

Frequently asked questions about flying from Knoxville to Santa Ana, California

  • How far is Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty by plane?

    Knoxville McGhee Tyson and Santa Ana J. Wayne/Orange Cnty are 1919.8 mi apart from one another. Typically, this will take 6h 44m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The required travel and health documents for your Santa Ana J. Wayne/Orange Cnty Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santa Ana, California?

Best airlines flying from Knoxville to Santa Ana, California

Compare and see reviews for airlines that fly from Knoxville to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $282Free CancellationRating
7.9
8,454 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
9,694 reviews
Search United Airlines flights
American AirlinesPriceFrom $288Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
Tustin

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Santa Ana for you.

Can I find flights from Knoxville to Santa Ana with flexible booking policies on momondo?

Flights from Knoxville to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Santa Ana?

momondo provides multiple filters to help you find the best flight to Santa Ana from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Santa Ana right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santa Ana flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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