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Cheap flights from Knoxville to Los Angeles from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Los Angeles departing on 8/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:00 am - 8:05 am
TYS
-
SNA
28h 05m
1 stop
Multiple Airlines Logo
2:27 pm - 11:37 pm
SNA
-
TYS
6h 10m
1 stop
$322Multiple Airlines
Do, Jul 30 - Do, Aug 6
American Airlines Logo
6:03 am - 10:50 am
TYS
-
SNA
7h 47m
1 stop
American Airlines Logo
1:34 pm - 11:18 pm
SNA
-
TYS
6h 44m
1 stop
$345American Airlines
Do, Aug 27 - Mo, Aug 31
Southwest Logo
4:00 pm - 9:00 pm
TYS
-
SNA
8h 00m
1 stop
Southwest Logo
7:45 am - 6:40 pm
SNA
-
TYS
7h 55m
1 stop
$346Southwest
Do, Okt 1 - Mo, Okt 5
United Airlines Logo
10:42 am - 5:31 pm
TYS
-
SNA
9h 49m
2 stops
United Airlines Logo
10:37 am - 9:00 pm
SNA
-
TYS
7h 23m
1 stop
$350United Airlines
Mi, Sep 30 - Sa, Okt 3
Southwest Logo
4:50 pm - 9:55 pm
TYS
-
SNA
8h 05m
1 stop
Southwest Logo
6:45 am - 6:55 pm
SNA
-
TYS
9h 10m
2 stops
$351Southwest
Do, Sep 10 - Di, Sep 15
Southwest Logo
4:50 pm - 9:55 pm
TYS
-
SNA
8h 05m
1 stop
Southwest Logo
8:45 pm - 12:05 pm
SNA
-
TYS
12h 20m
2 stops
$357Southwest
Do, Sep 10 - Mo, Sep 14
Southwest Logo
2:05 pm - 9:10 pm
TYS
-
SNA
10h 05m
2 stops
Southwest Logo
7:05 pm - 12:05 pm
SNA
-
TYS
14h 00m
2 stops
$362Southwest
Do, Sep 10 - Mo, Sep 14
American Airlines Logo
11:49 am - 3:45 pm
TYS
-
SNA
6h 56m
1 stop
American Airlines Logo
12:14 pm - 11:22 pm
SNA
-
TYS
8h 08m
1 stop
$367American Airlines
Do, Sep 10 - Di, Sep 15
Southwest Logo
3:00 pm - 6:35 pm
TYS
-
SNA
6h 35m
1 stop
Southwest Logo
8:40 pm - 1:25 pm
SNA
-
TYS
13h 45m
2 stops
$373Southwest
Mi, Aug 26 - Do, Aug 27
United Airlines Logo
7:00 am - 1:53 pm
TYS
-
SNA
9h 53m
2 stops
United Airlines Logo
12:06 pm - 9:45 pm
SNA
-
TYS
6h 39m
1 stop
$374United Airlines
Do, Aug 27 - Mo, Aug 31

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American Airlines flights from Knoxville to Santa Ana, California

Our best American Airlines deals on Knoxville to Santa Ana, California flight tickets
American Airlines
Aug 27
TYS6:03 amKnoxville McGhee Tyson
7h 47m
1 stop
SNA10:50 amSanta Ana J. Wayne/Orange Cnty
Aug 31
SNA1:34 pmSanta Ana J. Wayne/Orange Cnty
6h 44m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
$345
American Airlines
Sep 10
TYS11:49 amKnoxville McGhee Tyson
6h 56m
1 stop
SNA3:45 pmSanta Ana J. Wayne/Orange Cnty
Sep 15
SNA12:14 pmSanta Ana J. Wayne/Orange Cnty
8h 08m
1 stop
TYS11:22 pmKnoxville McGhee Tyson
$367
American Airlines
Aug 16
TYS7:19 amKnoxville McGhee Tyson
6h 31m
1 stop
SNA10:50 amSanta Ana J. Wayne/Orange Cnty
Aug 20
SNA1:49 pmSanta Ana J. Wayne/Orange Cnty
6h 29m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
$401

United Airlines flights from Knoxville to Santa Ana, California

Our best United Airlines deals on Knoxville to Santa Ana, California flight tickets
United Airlines
Sep 30
TYS10:42 amKnoxville McGhee Tyson
9h 49m
2 stops
SNA5:31 pmSanta Ana J. Wayne/Orange Cnty
Oct 3
SNA10:37 amSanta Ana J. Wayne/Orange Cnty
7h 23m
1 stop
TYS9:00 pmKnoxville McGhee Tyson
$350
United Airlines
Aug 27
TYS7:00 amKnoxville McGhee Tyson
9h 53m
2 stops
SNA1:53 pmSanta Ana J. Wayne/Orange Cnty
Aug 31
SNA12:06 pmSanta Ana J. Wayne/Orange Cnty
6h 39m
1 stop
TYS9:45 pmKnoxville McGhee Tyson
$374
United Airlines
Nov 17
TYS5:15 pmKnoxville McGhee Tyson
7h 40m
1 stop
SNA9:55 pmSanta Ana J. Wayne/Orange Cnty
Nov 18
SNA8:00 amSanta Ana J. Wayne/Orange Cnty
6h 48m
1 stop
TYS5:48 pmKnoxville McGhee Tyson
$445

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated Juni 30, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Do 7/30

7:00 am-8:05 am

1 stop28h 05m

Santa Ana J. Wayne/Orange Cnty

Do 8/6

2:27 pm-11:37 pm

1 stop6h 10m

$322
Quickest round-trip

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Do 8/27

6:03 am-10:50 am

1 stop7h 47m

Santa Ana J. Wayne/Orange Cnty

Mo 8/31

1:34 pm-11:18 pm

1 stop6h 44m

$345

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Do 10/1

4:00 pm-9:00 pm

1 stop8h 00m

Santa Ana J. Wayne/Orange Cnty

Mo 10/5

7:45 am-6:40 pm

1 stop7h 55m

$346

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mi 9/30

10:42 am-5:31 pm

2 stops9h 49m

Santa Ana J. Wayne/Orange Cnty

Sa 10/3

10:37 am-9:00 pm

1 stop7h 23m

$350

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Do 9/10

4:50 pm-9:55 pm

1 stop8h 05m

Santa Ana J. Wayne/Orange Cnty

Di 9/15

6:45 am-6:55 pm

2 stops9h 10m

$351

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Do 9/10

4:50 pm-9:55 pm

1 stop8h 05m

Santa Ana J. Wayne/Orange Cnty

Mo 9/14

8:45 pm-12:05 pm

2 stops12h 20m

$357

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Do 9/10

2:05 pm-9:10 pm

2 stops10h 05m

Santa Ana J. Wayne/Orange Cnty

Mo 9/14

7:05 pm-12:05 pm

2 stops14h 00m

$362

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Do 9/10

11:49 am-3:45 pm

1 stop6h 56m

Santa Ana J. Wayne/Orange Cnty

Di 9/15

12:14 pm-11:22 pm

1 stop8h 08m

$367

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mi 8/26

3:00 pm-6:35 pm

1 stop6h 35m

Santa Ana J. Wayne/Orange Cnty

Do 8/27

8:40 pm-1:25 pm

2 stops13h 45m

$373

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Do 8/27

7:00 am-1:53 pm

2 stops9h 53m

Santa Ana J. Wayne/Orange Cnty

Mo 8/31

12:06 pm-9:45 pm

1 stop6h 39m

$374

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Santa Ana, California?

What is the cheapest month to fly to Santa Ana, California?

In general, May is the cheapest month to fly from Knoxville to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $338. If you aren’t able to travel during the month of May, then book flights to Santa Ana, California from Knoxville during August instead. Flights to Santa Ana, California in August, while not as cheap as those in May, still average around $398.

How far in advance should I book a flight from Knoxville to Santa Ana, California?

You are more likely to see cheaper flights to Santa Ana, California from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $539 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from Knoxville for as low as $288 on momondo.

How have Knoxville to Santa Ana, California flight prices changed over time?

As of June 2026, prices for Knoxville to Santa Ana, California flights are approximately 30% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santa Ana, California (TYS to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santa Ana, California

Fastest flight time

6h 44m

Direct flights

None
The fastest flight from Knoxville to Santa Ana, California takes 6h 44m
There are no direct flights from Knoxville to Santa Ana, California. There are no popular flight routes from Knoxville to Santa Ana, California.
Search flight deals

Frequently asked questions about flying from Knoxville to Santa Ana, California

  • How far is Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty by plane?

    Knoxville McGhee Tyson and Santa Ana J. Wayne/Orange Cnty are 1919.8 mi apart from one another. Typically, this will take 6h 44m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The required travel and health documents for your Santa Ana J. Wayne/Orange Cnty Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santa Ana, California?

Best airlines flying from Knoxville to Santa Ana, California

Compare and see reviews for airlines that fly from Knoxville to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $228Free CancellationRating
7.8
8,451 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
9,901 reviews
Search United Airlines flights
American AirlinesPriceFrom $288Free CancellationRating
7.1
11,762 reviews
Search American Airlines flights
SouthwestPriceFrom $378Free CancellationRating
7.9
4,247 reviews
Search Southwest flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
Tustin

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Santa Ana for you.

Can I find flights from Knoxville to Santa Ana with flexible booking policies on momondo?

Flights from Knoxville to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Santa Ana?

momondo provides multiple filters to help you find the best flight to Santa Ana from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Santa Ana right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santa Ana flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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