Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to Los Angeles from $154

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Los Angeles departing on 4/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:00 am - 3:35 pm
TYS
-
SNA
10h 35m
1 stop
Multiple Airlines Logo
8:14 pm - 10:51 pm
SNA
-
TYS
23h 37m
1 stop
$295Multiple Airlines
Thu, May 7 - Sun, May 10
Multiple Airlines Logo
1:43 pm - 2:28 pm
TYS
-
SNA
27h 45m
1 stop
Multiple Airlines Logo
7:56 pm - 10:51 pm
SNA
-
TYS
23h 55m
1 stop
$321Multiple Airlines
Mon, Apr 20 - Thu, Apr 23
American Airlines Logo
4:09 pm - 10:45 pm
TYS
-
SNA
9h 36m
1 stop
American Airlines Logo
1:23 pm - 11:56 pm
SNA
-
TYS
7h 33m
1 stop
$339American Airlines
Sat, Apr 25 - Tue, Apr 28
Multiple Airlines Logo
12:49 pm - 3:23 pm
TYS
-
SNA
29h 34m
1 stop
Multiple Airlines Logo
1:50 pm - 10:52 pm
SNA
-
TYS
6h 02m
1 stop
$342Multiple Airlines
Mon, Aug 24 - Sun, Aug 30
Multiple Airlines Logo
2:51 pm - 1:05 pm
TYS
-
SNA
25h 14m
1 stop
Multiple Airlines Logo
7:30 am - 1:57 pm
SNA
-
TYS
27h 27m
1 stop
$343Multiple Airlines
Thu, Aug 6 - Thu, Aug 13
Multiple Airlines Logo
2:51 pm - 1:05 pm
TYS
-
SNA
25h 14m
1 stop
Multiple Airlines Logo
8:55 am - 7:37 pm
SNA
-
TYS
7h 42m
1 stop
$345Multiple Airlines
Thu, Aug 6 - Mon, Aug 10
United Airlines Logo
7:05 am - 11:13 am
TYS
-
SNA
7h 08m
1 stop
United Airlines Logo
12:15 pm - 11:41 pm
SNA
-
TYS
8h 26m
1 stop
$347United Airlines
Wed, Apr 22 - Sat, Apr 25
Delta Logo
4:00 pm - 10:14 pm
TYS
-
SNA
9h 14m
1 stop
Delta Logo
6:45 am - 5:17 pm
SNA
-
TYS
7h 32m
1 stop
$349Delta
Wed, Aug 12 - Tue, Aug 25
Multiple Airlines Logo
2:51 pm - 1:05 pm
TYS
-
SNA
25h 14m
1 stop
Multiple Airlines Logo
1:50 pm - 10:52 pm
SNA
-
TYS
6h 02m
1 stop
$350Multiple Airlines
Thu, Aug 13 - Sun, Aug 23
American Airlines Logo
6:00 am - 10:08 am
TYS
-
SNA
7h 08m
1 stop
American Airlines Logo
2:42 pm - 11:56 pm
SNA
-
TYS
6h 14m
1 stop
$351American Airlines
Sat, Apr 11 - Tue, Apr 14

American Airlines flights from Knoxville to Santa Ana

Our best American Airlines deals on Knoxville to Santa Ana flight tickets
American Airlines
Apr 25
TYS4:09 pmKnoxville McGhee Tyson
9h 36m
1 stop
SNA10:45 pmSanta Ana J. Wayne/Orange Cnty
Apr 28
SNA1:23 pmSanta Ana J. Wayne/Orange Cnty
7h 33m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
$339
American Airlines
Apr 11
TYS6:00 amKnoxville McGhee Tyson
7h 08m
1 stop
SNA10:08 amSanta Ana J. Wayne/Orange Cnty
Apr 14
SNA2:42 pmSanta Ana J. Wayne/Orange Cnty
6h 14m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
$351
American Airlines
Mar 30
TYS5:40 amKnoxville McGhee Tyson
7h 25m
1 stop
SNA10:05 amSanta Ana J. Wayne/Orange Cnty
Apr 3
SNA2:47 pmSanta Ana J. Wayne/Orange Cnty
6h 04m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
$669

United Airlines flights from Knoxville to Santa Ana

Our best United Airlines deals on Knoxville to Santa Ana flight tickets
United Airlines
Apr 22
TYS7:05 amKnoxville McGhee Tyson
7h 08m
1 stop
SNA11:13 amSanta Ana J. Wayne/Orange Cnty
Apr 25
SNA12:15 pmSanta Ana J. Wayne/Orange Cnty
8h 26m
1 stop
TYS11:41 pmKnoxville McGhee Tyson
$347
United Airlines
Apr 25
TYS7:05 amKnoxville McGhee Tyson
7h 08m
1 stop
SNA11:13 amSanta Ana J. Wayne/Orange Cnty
Apr 28
SNA9:00 amSanta Ana J. Wayne/Orange Cnty
10h 34m
2 stops
TYS10:34 pmKnoxville McGhee Tyson
$354
United Airlines
Mar 28
TYS4:55 pmKnoxville McGhee Tyson
7h 50m
1 stop
SNA9:45 pmSanta Ana J. Wayne/Orange Cnty
Apr 4
SNA12:15 pmSanta Ana J. Wayne/Orange Cnty
8h 26m
1 stop
TYS11:41 pmKnoxville McGhee Tyson
$489

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 5/7

8:00 am-3:35 pm

1 stop10h 35m

Santa Ana J. Wayne/Orange Cnty

Sun 5/10

8:14 pm-10:51 pm

1 stop23h 37m

$295

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 4/20

1:43 pm-2:28 pm

1 stop27h 45m

Santa Ana J. Wayne/Orange Cnty

Thu 4/23

7:56 pm-10:51 pm

1 stop23h 55m

$321

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 4/25

4:09 pm-10:45 pm

1 stop9h 36m

Santa Ana J. Wayne/Orange Cnty

Tue 4/28

1:23 pm-11:56 pm

1 stop7h 33m

$339

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 8/24

12:49 pm-3:23 pm

1 stop29h 34m

Santa Ana J. Wayne/Orange Cnty

Sun 8/30

1:50 pm-10:52 pm

1 stop6h 02m

$342

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 8/6

2:51 pm-1:05 pm

1 stop25h 14m

Santa Ana J. Wayne/Orange Cnty

Thu 8/13

7:30 am-1:57 pm

1 stop27h 27m

$343

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 8/6

2:51 pm-1:05 pm

1 stop25h 14m

Santa Ana J. Wayne/Orange Cnty

Mon 8/10

8:55 am-7:37 pm

1 stop7h 42m

$345

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 4/22

7:05 am-11:13 am

1 stop7h 08m

Santa Ana J. Wayne/Orange Cnty

Sat 4/25

12:15 pm-11:41 pm

1 stop8h 26m

$347

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 8/12

4:00 pm-10:14 pm

1 stop9h 14m

Santa Ana J. Wayne/Orange Cnty

Tue 8/25

6:45 am-5:17 pm

1 stop7h 32m

$349

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 8/13

2:51 pm-1:05 pm

1 stop25h 14m

Santa Ana J. Wayne/Orange Cnty

Sun 8/23

1:50 pm-10:52 pm

1 stop6h 02m

$350
Quickest round-trip

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 4/11

6:00 am-10:08 am

1 stop7h 08m

Santa Ana J. Wayne/Orange Cnty

Tue 4/14

2:42 pm-11:56 pm

1 stop6h 14m

$351

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Los Angeles from

How to get the cheapest flight ticket from Knoxville to Santa Ana

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santa Ana?

The cheapest month to fly to Santa Ana from Knoxville is in May. Flight prices, which tend to average around $334, are often lower during this time because this is during the off-season. The month of September is another great option to travel to Santa Ana, with average flight prices from Knoxville averaging around $378.

How far in advance should I book a flight to Santa Ana?

You are more likely to see cheaper flights to Santa Ana from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana for around $482 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana from Knoxville for as low as $228 on momondo.

How have Knoxville to Santa Ana flight prices changed over time?

As of March 2026, prices for Knoxville to Santa Ana flights are approximately 56% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to Santa Ana

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santa Ana according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santa Ana (TYS to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santa Ana

Fastest flight time

7h 42m

Direct flights

None
The fastest flight from Knoxville to Santa Ana takes 7h 42m
There are no direct flights from Knoxville to Santa Ana. There are no popular flight routes from Knoxville to Santa Ana.
Search flight deals

  • How far is Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty by plane?

    Knoxville McGhee Tyson and Santa Ana J. Wayne/Orange Cnty are 1919.8 mi apart from one another. Typically, this will take 7h 42m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The required travel and health documents for your Santa Ana J. Wayne/Orange Cnty Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santa Ana?

Best airlines flying from Knoxville to Santa Ana

Compare and see reviews for airlines that fly from Knoxville to Santa Ana with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $282Free CancellationRating
7.9
8,320 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
9,467 reviews
Search United Airlines flights
American AirlinesPriceFrom $288Free CancellationRating
7.1
11,492 reviews
Search American Airlines flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
Tustin

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Santa Ana for you.

Can I find flights from Knoxville to Santa Ana with flexible booking policies on momondo?

Flights from Knoxville to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Santa Ana?

momondo provides multiple filters to help you find the best flight to Santa Ana from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Santa Ana right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santa Ana flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Santa Ana trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 4/23
Thu 4/30
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States