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Cheap flights from Knoxville to Los Angeles from $150

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Los Angeles departing on 9/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:00 am - 11:05 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 05m1 stop Denver Intl
Multiple Airlines Logo
9:30 am - 10:53 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
10h 23m1 stop Phoenix Sky Harbor Intl
$280Multiple Airlines
Thu, Sep 10 - Sun, Sep 13
United Airlines Logo
9:00 am - 3:20 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
9h 20m1 stop Denver Intl
United Airlines Logo
12:06 pm - 9:45 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 39m1 stop Houston George Bush Intcntl
$299United Airlines
Sat, Sep 5 - Sat, Sep 12
United Airlines Logo
4:50 pm - 8:39 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
6h 49m1 stop Denver Intl
United Airlines Logo
8:55 am - 10:49 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
10h 54m2 stops Denver Intl Chicago O'Hare Intl
$304United Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
6:00 am - 9:45 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
6h 45m1 stop Dallas/Fort Worth
American Airlines Logo
1:40 pm - 11:22 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 42m1 stop Dallas/Fort Worth
$317American Airlines
Wed, Sep 16 - Wed, Sep 23
American Airlines Logo
6:00 am - 9:45 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
6h 45m1 stop Dallas/Fort Worth
American Airlines Logo
1:40 pm - 11:22 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 42m1 stop Dallas/Fort Worth
$317American Airlines
Wed, Sep 16 - Mon, Sep 21
Multiple Airlines Logo
7:00 am - 11:05 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 05m1 stop Denver Intl
Multiple Airlines Logo
11:50 am - 8:39 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
29h 49m2 stops Denver Intl Orlando
$322Multiple Airlines
Thu, Sep 10 - Sun, Sep 13
Southwest Logo
3:15 pm - 7:35 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 20m1 stop Austin Bergstrom
Southwest Logo
7:45 pm - 12:05 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
13h 20m2 stops Denver Intl Nashville Intl
$352Southwest
Fri, Sep 25 - Mon, Sep 28
Southwest Logo
4:50 pm - 10:10 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
8h 20m2 stops Denver Intl Phoenix Sky Harbor Intl
Southwest Logo
7:45 pm - 12:05 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
13h 20m2 stops Denver Intl Nashville Intl
$357Southwest
Fri, Sep 25 - Mon, Sep 28
Delta Logo
6:13 pm - 10:04 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
6h 51m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:00 pm - 11:55 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 55m1 stop Atlanta Hartsfield-Jackson
$383Delta
Thu, Sep 17 - Wed, Sep 23
Delta Logo
6:23 pm - 10:12 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
6h 49m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:45 am - 5:38 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 53m1 stop Atlanta Hartsfield-Jackson
$454Delta
Fri, Oct 23 - Sat, Oct 31

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Delta flights from Knoxville to Santa Ana, California

Our best Delta deals on Knoxville to Santa Ana, California flight tickets
Delta
Sep 17
TYS6:13 pmKnoxville McGhee Tyson
6h 51m
1 stop
SNA10:04 pmSanta Ana J. Wayne/Orange Cnty
Sep 23
SNA2:00 pmSanta Ana J. Wayne/Orange Cnty
6h 55m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
$383
Delta
Oct 23
TYS6:23 pmKnoxville McGhee Tyson
6h 49m
1 stop
SNA10:12 pmSanta Ana J. Wayne/Orange Cnty
Oct 31
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
7h 53m
1 stop
TYS5:38 pmKnoxville McGhee Tyson
$454

Southwest flights from Knoxville to Santa Ana, California

Our best Southwest deals on Knoxville to Santa Ana, California flight tickets
Southwest
Sep 25
TYS3:15 pmKnoxville McGhee Tyson
7h 20m
1 stop
SNA7:35 pmSanta Ana J. Wayne/Orange Cnty
Sep 28
SNA7:45 pmSanta Ana J. Wayne/Orange Cnty
13h 20m
2 stops
TYS12:05 pmKnoxville McGhee Tyson
$352
Southwest
Sep 25
TYS4:50 pmKnoxville McGhee Tyson
8h 20m
2 stops
SNA10:10 pmSanta Ana J. Wayne/Orange Cnty
Sep 28
SNA7:45 pmSanta Ana J. Wayne/Orange Cnty
13h 20m
2 stops
TYS12:05 pmKnoxville McGhee Tyson
$357
Southwest
Sep 16
TYS3:00 pmKnoxville McGhee Tyson
8h 55m
1 stop
SNA8:55 pmSanta Ana J. Wayne/Orange Cnty
Sep 21
SNA7:45 pmSanta Ana J. Wayne/Orange Cnty
13h 20m
2 stops
TYS12:05 pmKnoxville McGhee Tyson
$387

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Thu 9/10

7:00 am-11:05 am

1 stop7h 05m

Santa Ana J. Wayne/Orange Cnty

Sun 9/13

9:30 am-10:53 pm

1 stop10h 23m

$280

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Sat 9/5

9:00 am-3:20 pm

1 stop9h 20m

Santa Ana J. Wayne/Orange Cnty

Sat 9/12

12:06 pm-9:45 pm

1 stop6h 39m

$299

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Sat 9/5

4:50 pm-8:39 pm

1 stop6h 49m

Santa Ana J. Wayne/Orange Cnty

Sat 9/12

8:55 am-10:49 pm

2 stops10h 54m

$304
Quickest round-trip

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Wed 9/16

6:00 am-9:45 am

1 stop6h 45m

Santa Ana J. Wayne/Orange Cnty

Wed 9/23

1:40 pm-11:22 pm

1 stop6h 42m

$317

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Wed 9/16

6:00 am-9:45 am

1 stop6h 45m

Santa Ana J. Wayne/Orange Cnty

Mon 9/21

1:40 pm-11:22 pm

1 stop6h 42m

$317

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Thu 9/10

7:00 am-11:05 am

1 stop7h 05m

Santa Ana J. Wayne/Orange Cnty

Sun 9/13

11:50 am-8:39 pm

2 stops29h 49m

$322

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Fri 9/25

3:15 pm-7:35 pm

1 stop7h 20m

Santa Ana J. Wayne/Orange Cnty

Mon 9/28

7:45 pm-12:05 pm

2 stops13h 20m

$352

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Fri 9/25

4:50 pm-10:10 pm

2 stops8h 20m

Santa Ana J. Wayne/Orange Cnty

Mon 9/28

7:45 pm-12:05 pm

2 stops13h 20m

$357

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Thu 9/17

6:13 pm-10:04 pm

1 stop6h 51m

Santa Ana J. Wayne/Orange Cnty

Wed 9/23

2:00 pm-11:55 pm

1 stop6h 55m

$383

KnoxvilleSanta Ana

TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty

TYSSNA

Knoxville McGhee Tyson

Fri 10/23

6:23 pm-10:12 pm

1 stop6h 49m

Santa Ana J. Wayne/Orange Cnty

Sat 10/31

6:45 am-5:38 pm

1 stop7h 53m

$454

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Santa Ana, California?

Prices are currently low for flights on this route.

Typical prices usually range from $362 to $472.
The lowest price recently found on this route was $280.

What is the cheapest month to fly to Santa Ana, California?

In general, May is the cheapest month to fly from Knoxville to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $448. If you aren’t able to travel during the month of May, then book flights to Santa Ana, California from Knoxville during August instead. Flights to Santa Ana, California in August, while not as cheap as those in May, still average around $456.

How far in advance should I book a flight from Knoxville to Santa Ana, California?

You are more likely to see cheaper flights to Santa Ana, California from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $570 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from Knoxville for as low as $288 on momondo.

How have Knoxville to Santa Ana, California flight prices changed over time?

As of August 2026, prices for Knoxville to Santa Ana, California flights are approximately 124% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santa Ana, California (TYS to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santa Ana, California

Fastest flight time

7h 05m

Direct flights

None
The fastest flight from Knoxville to Santa Ana, California takes 7h 05m
There are no direct flights from Knoxville to Santa Ana, California. There are no popular flight routes from Knoxville to Santa Ana, California.
Search flight deals

Frequently asked questions about flying from Knoxville to Santa Ana, California

  • How far is Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty by plane?

    Knoxville McGhee Tyson and Santa Ana J. Wayne/Orange Cnty are 1919.8 mi apart from one another. Typically, this will take 7h 05m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The required travel and health documents for your Santa Ana J. Wayne/Orange Cnty Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santa Ana, California?

Best airlines flying from Knoxville to Santa Ana, California

Compare and see reviews for airlines that fly from Knoxville to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $228Free CancellationRating
7.8
8,503 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
10,106 reviews
Search United Airlines flights
American AirlinesPriceFrom $292Free CancellationRating
7.1
11,944 reviews
Search American Airlines flights
SouthwestPriceFrom $378Free CancellationRating
8.0
4,218 reviews
Search Southwest flights

Traveling to a place near Los Angeles?

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Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Santa Ana for you.

Can I find flights from Knoxville to Santa Ana with flexible booking policies on momondo?

Flights from Knoxville to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Santa Ana?

momondo provides multiple filters to help you find the best flight to Santa Ana from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Santa Ana right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santa Ana flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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