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Cheap flights from Knoxville to Los Angeles from $146

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Los Angeles departing on 9/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Los Angeles

Cheap round-trip flights

Logo
2:54 pm - 9:21 pmTYS-SNA
9h 27m1 stop
Logo
8:30 pm - 11:08 pmSNA-TYS
23h 38m2 stops
$262
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Fri, Aug 22 - Wed, Sep 3
Logo
2:54 pm - 7:35 pmTYS-SNA
7h 41m1 stop
Logo
6:45 am - 11:18 amSNA-TYS
25h 33m3 stops
$267
Find Deal
Fri, Aug 22 - Wed, Sep 3
Frontier Logo
8:40 pm - 11:07 amTYS-SNA
17h 27m1 stop
Frontier Logo
11:52 am - 7:45 pmSNA-TYS
28h 53m1 stop
$285Frontier
Find Deal
Thu, Sep 4 - Sun, Sep 7
American Airlines Logo
5:30 am - 10:33 amTYS-SNA
8h 03m1 stop
American Airlines Logo
8:30 am - 6:54 pmSNA-TYS
7h 24m1 stop
$289American Airlines
Find Deal
Sat, Aug 23 - Mon, Aug 25
American Airlines Logo
5:30 am - 10:33 amTYS-SNA
8h 03m1 stop
American Airlines Logo
12:50 pm - 12:19 amSNA-TYS
8h 29m2 stops
$294American Airlines
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Sat, Aug 23 - Mon, Aug 25
Logo
1:22 pm - 7:35 pmTYS-SNA
33h 13m3 stops
Logo
8:30 pm - 11:08 pmSNA-TYS
23h 38m2 stops
$298
Find Deal
Fri, Aug 22 - Wed, Sep 3
American Airlines Logo
5:30 am - 11:57 amTYS-SNA
9h 27m2 stops
American Airlines Logo
12:50 pm - 12:19 amSNA-TYS
8h 29m2 stops
$299American Airlines
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Sat, Aug 23 - Mon, Aug 25
Delta Logo
5:45 am - 11:53 amTYS-SNA
9h 08m2 stops
Delta Logo
7:12 pm - 9:30 amSNA-TYS
11h 18m2 stops
$409Delta
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Fri, Aug 15 - Mon, Aug 18
Delta Logo
3:48 pm - 10:28 pmTYS-SNA
9h 40m1 stop
Delta Logo
9:30 pm - 9:00 amSNA-TYS
8h 30m1 stop
$425Delta
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Mon, Oct 6 - Sun, Oct 12
United Airlines Logo
4:40 pm - 8:29 pmTYS-SNA
6h 49m1 stop
United Airlines Logo
11:15 am - 11:59 pmSNA-TYS
9h 44m2 stops
$490United Airlines
Find Deal
Wed, Oct 22 - Mon, Oct 27

American Airlines flights from Knoxville to Santa Ana

Our best American Airlines deals on Knoxville to Santa Ana flight tickets
American Airlines
Aug 23
TYS5:30 amKnoxville McGhee Tyson
8h 03m
1 stop
SNA10:33 amSanta Ana J. Wayne/Orange Cnty
Aug 25
SNA8:30 amSanta Ana J. Wayne/Orange Cnty
7h 24m
1 stop
TYS6:54 pmKnoxville McGhee Tyson
$289
Find similar
American Airlines
Aug 23
TYS5:30 amKnoxville McGhee Tyson
8h 03m
1 stop
SNA10:33 amSanta Ana J. Wayne/Orange Cnty
Aug 25
SNA12:50 pmSanta Ana J. Wayne/Orange Cnty
8h 29m
2 stops
TYS12:19 amKnoxville McGhee Tyson
$294
Find similar
American Airlines
Aug 23
TYS5:30 amKnoxville McGhee Tyson
9h 27m
2 stops
SNA11:57 amSanta Ana J. Wayne/Orange Cnty
Aug 25
SNA12:50 pmSanta Ana J. Wayne/Orange Cnty
8h 29m
2 stops
TYS12:19 amKnoxville McGhee Tyson
$299
Find similar

Delta flights from Knoxville to Santa Ana

Our best Delta deals on Knoxville to Santa Ana flight tickets
Delta
Aug 6
TYS5:30 amKnoxville McGhee Tyson
8h 20m
1 stop
SNA10:50 amSanta Ana J. Wayne/Orange Cnty
Aug 12
SNA2:00 pmSanta Ana J. Wayne/Orange Cnty
6h 48m
1 stop
TYS11:48 pmKnoxville McGhee Tyson
$377
Find similar
Delta
Aug 6
TYS5:30 amKnoxville McGhee Tyson
8h 20m
1 stop
SNA10:50 amSanta Ana J. Wayne/Orange Cnty
Aug 12
SNA7:05 amSanta Ana J. Wayne/Orange Cnty
13h 46m
2 stops
TYS11:51 pmKnoxville McGhee Tyson
$382
Find similar
Delta
Aug 15
TYS5:45 amKnoxville McGhee Tyson
9h 08m
2 stops
SNA11:53 amSanta Ana J. Wayne/Orange Cnty
Aug 18
SNA7:12 pmSanta Ana J. Wayne/Orange Cnty
11h 18m
2 stops
TYS9:30 amKnoxville McGhee Tyson
$409
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 8/22

2:54 pm-9:21 pm

1 stop9h 27m

Santa Ana J. Wayne/Orange Cnty

Wed 9/3

8:30 pm-11:08 pm

2 stops23h 38m

$262

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 8/22

2:54 pm-7:35 pm

1 stop7h 41m

Santa Ana J. Wayne/Orange Cnty

Wed 9/3

6:45 am-11:18 am

3 stops25h 33m

$267

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 9/4

8:40 pm-11:07 am

1 stop17h 27m

Santa Ana J. Wayne/Orange Cnty

Sun 9/7

11:52 am-7:45 pm

1 stop28h 53m

$285

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 8/23

5:30 am-10:33 am

1 stop8h 03m

Santa Ana J. Wayne/Orange Cnty

Mon 8/25

8:30 am-6:54 pm

1 stop7h 24m

$289

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 8/23

5:30 am-10:33 am

1 stop8h 03m

Santa Ana J. Wayne/Orange Cnty

Mon 8/25

12:50 pm-12:19 am

2 stops8h 29m

$294

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 8/22

1:22 pm-7:35 pm

3 stops33h 13m

Santa Ana J. Wayne/Orange Cnty

Wed 9/3

8:30 pm-11:08 pm

2 stops23h 38m

$298

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 8/23

5:30 am-11:57 am

2 stops9h 27m

Santa Ana J. Wayne/Orange Cnty

Mon 8/25

12:50 pm-12:19 am

2 stops8h 29m

$299

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 8/15

5:45 am-11:53 am

2 stops9h 08m

Santa Ana J. Wayne/Orange Cnty

Mon 8/18

7:12 pm-9:30 am

2 stops11h 18m

$409

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 10/6

3:48 pm-10:28 pm

1 stop9h 40m

Santa Ana J. Wayne/Orange Cnty

Sun 10/12

9:30 pm-9:00 am

1 stop8h 30m

$425

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 10/22

4:40 pm-8:29 pm

1 stop6h 49m

Santa Ana J. Wayne/Orange Cnty

Mon 10/27

11:15 am-11:59 pm

2 stops9h 44m

$490

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Santa Ana

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santa Ana?

The cheapest month to fly to Santa Ana from Knoxville is in February. Flight prices, which tend to average around $301, are often lower during this time because this is during the off-season. The month of May is another great option to travel to Santa Ana, with average flight prices from Knoxville averaging around $340.

What is the cheapest day to depart on your flight to Santa Ana?

On average, the least expensive day to fly to Santa Ana from Knoxville is on a Saturday. momondo users have found tickets for Saturday departures for as low as $406. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Sunday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $715.

What is the cheapest time of day to depart on your flight to Santa Ana?

Our data shows that the cheapest Knoxville to Santa Ana flights are usually those with departure times at noon. Our users have found flights to Santa Ana at noon for as low as $388. Try not to purchase tickets in the afternoon because they tend to be around $477. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Santa Ana?

You are more likely to see cheaper flights to Santa Ana from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana for around $398 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana from Knoxville for as low as $238 on momondo.

How have Knoxville to Santa Ana flight prices changed over time?

As of July 2025, prices for Knoxville to Santa Ana flights are approximately 44% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to Santa Ana

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santa Ana according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santa Ana (TYS to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santa Ana

Best Price Found

$146

Fastest flight time

6h 16m

Direct flights

None

Airports in Santa Ana

1 airport
The best one-way flight to Santa Ana from Knoxville in the past 72 hours is $146. The best round-trip flight deal from Knoxville to Santa Ana found on momondo in the last 72 hours is $262.
The fastest flight from Knoxville to Santa Ana takes 6h 16m
There are no direct flights from Knoxville to Santa Ana. Popular non-direct route for this connection is Knoxville McGhee Tyson Airport - Santa Ana J. Wayne/Orange Cnty Airport.
There is 1 airport near Santa Ana: Santa Ana J. Wayne/Orange Cnty (SNA)
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  • How far is Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty by plane?

    Knoxville McGhee Tyson and Santa Ana J. Wayne/Orange Cnty are 1919.8 mi apart from one another. Typically, this will take 6h 40m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The required travel and health documents for your Santa Ana J. Wayne/Orange Cnty Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santa Ana?

Best airlines flying from Knoxville to Santa Ana

Compare and see reviews for airlines that fly from Knoxville to Santa Ana with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $258Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights
DeltaPriceFrom $282Free CancellationRating
8.0
7,981 reviews
Search Delta flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
Tustin

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Santa Ana for you.

Can I find flights from Knoxville to Santa Ana with flexible booking policies on momondo?

Flights from Knoxville to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Santa Ana?

momondo provides multiple filters to help you find the best flight to Santa Ana from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Santa Ana right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santa Ana flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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