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Cheap flights from Knoxville to Los Angeles from $76

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Los Angeles departing on 12/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:16 pm - 9:01 pmTYS-SNA
34h 45m2 stops
Multiple Airlines Logo
5:46 pm - 5:32 pmSNA-TYS
20h 46m1 stop
$269Multiple Airlines
Find Deal
Sun, Nov 16 - Thu, Nov 20
American Airlines Logo
5:45 pm - 10:59 pmTYS-SNA
8h 14m1 stop
American Airlines Logo
11:41 am - 9:40 pmSNA-TYS
6h 59m1 stop
$289American Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9
American Airlines Logo
5:45 pm - 10:59 pmTYS-SNA
8h 14m1 stop
American Airlines Logo
9:59 am - 11:59 pmSNA-TYS
11h 00m2 stops
$294American Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9
Delta Logo
8:35 am - 4:08 pmTYS-SNA
10h 33m2 stops
Delta Logo
5:20 pm - 9:38 amSNA-TYS
13h 18m2 stops
$299Delta
Find Deal
Sat, Dec 6 - Tue, Dec 9
Multiple Airlines Logo
1:41 pm - 2:23 pmTYS-SNA
27h 42m2 stops
Multiple Airlines Logo
6:45 am - 5:02 pmSNA-TYS
7h 17m1 stop
$304Multiple Airlines
Find Deal
Fri, Dec 5 - Mon, Dec 8
Multiple Airlines Logo
8:00 am - 7:24 pmTYS-SNA
14h 24m1 stop
Multiple Airlines Logo
6:45 am - 5:02 pmSNA-TYS
7h 17m1 stop
$319Multiple Airlines
Find Deal
Fri, Dec 5 - Mon, Dec 8
United Airlines Logo
5:54 pm - 10:28 pmTYS-SNA
7h 34m1 stop
United Airlines Logo
11:10 am - 10:30 pmSNA-TYS
8h 20m1 stop
$363United Airlines
Find Deal
Wed, Dec 3 - Mon, Dec 8
United Airlines Logo
5:54 pm - 10:28 pmTYS-SNA
7h 34m1 stop
United Airlines Logo
11:10 am - 11:44 pmSNA-TYS
9h 34m2 stops
$368United Airlines
Find Deal
Wed, Dec 3 - Mon, Dec 8
Delta Logo
2:37 pm - 8:03 pmTYS-SNA
8h 26m1 stop
Delta Logo
9:20 pm - 9:21 amSNA-TYS
9h 01m1 stop
$437Delta
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Fri, Jan 23 - Sun, Jan 25
Southwest Logo
2:40 pm - 8:15 pmTYS-SNA
8h 35m1 stop
Southwest Logo
9:10 pm - 11:40 amSNA-TYS
11h 30m2 stops
$488Southwest
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Sun, Apr 19 - Fri, Apr 24

Delta flights from Knoxville to Santa Ana, California

Our best Delta deals on Knoxville to Santa Ana, California flight tickets
Delta
Dec 6
TYS8:35 amKnoxville McGhee Tyson
10h 33m
2 stops
SNA4:08 pmSanta Ana J. Wayne/Orange Cnty
Dec 9
SNA5:20 pmSanta Ana J. Wayne/Orange Cnty
13h 18m
2 stops
TYS9:38 amKnoxville McGhee Tyson
$299
Find similar
Delta
Oct 31
TYS5:44 amKnoxville McGhee Tyson
9h 06m
2 stops
SNA11:50 amSanta Ana J. Wayne/Orange Cnty
Nov 4
SNA12:26 pmSanta Ana J. Wayne/Orange Cnty
7h 56m
1 stop
TYS11:22 pmKnoxville McGhee Tyson
$384
Find similar
Delta
Oct 31
TYS5:44 amKnoxville McGhee Tyson
9h 06m
2 stops
SNA11:50 amSanta Ana J. Wayne/Orange Cnty
Nov 4
SNA7:00 pmSanta Ana J. Wayne/Orange Cnty
11h 00m
2 stops
TYS9:00 amKnoxville McGhee Tyson
$389
Find similar

United Airlines flights from Knoxville to Santa Ana, California

Our best United Airlines deals on Knoxville to Santa Ana, California flight tickets
United Airlines
Dec 3
TYS5:54 pmKnoxville McGhee Tyson
7h 34m
1 stop
SNA10:28 pmSanta Ana J. Wayne/Orange Cnty
Dec 8
SNA11:10 amSanta Ana J. Wayne/Orange Cnty
8h 20m
1 stop
TYS10:30 pmKnoxville McGhee Tyson
$363
Find similar
United Airlines
Dec 3
TYS5:54 pmKnoxville McGhee Tyson
7h 34m
1 stop
SNA10:28 pmSanta Ana J. Wayne/Orange Cnty
Dec 8
SNA11:10 amSanta Ana J. Wayne/Orange Cnty
9h 34m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
$368
Find similar
United Airlines
Apr 8
TYS8:45 amKnoxville McGhee Tyson
7h 29m
1 stop
SNA1:14 pmSanta Ana J. Wayne/Orange Cnty
Apr 11
SNA1:20 pmSanta Ana J. Wayne/Orange Cnty
6h 03m
1 stop
TYS10:23 pmKnoxville McGhee Tyson
$379
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Knoxville to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 11/16

1:16 pm-9:01 pm

2 stops34h 45m

Santa Ana J. Wayne/Orange Cnty

Thu 11/20

5:46 pm-5:32 pm

1 stop20h 46m

$269

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 12/6

5:45 pm-10:59 pm

1 stop8h 14m

Santa Ana J. Wayne/Orange Cnty

Tue 12/9

11:41 am-9:40 pm

1 stop6h 59m

$289

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 12/6

5:45 pm-10:59 pm

1 stop8h 14m

Santa Ana J. Wayne/Orange Cnty

Tue 12/9

9:59 am-11:59 pm

2 stops11h 00m

$294

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 12/6

8:35 am-4:08 pm

2 stops10h 33m

Santa Ana J. Wayne/Orange Cnty

Tue 12/9

5:20 pm-9:38 am

2 stops13h 18m

$299

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 12/5

1:41 pm-2:23 pm

2 stops27h 42m

Santa Ana J. Wayne/Orange Cnty

Mon 12/8

6:45 am-5:02 pm

1 stop7h 17m

$304

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 12/5

8:00 am-7:24 pm

1 stop14h 24m

Santa Ana J. Wayne/Orange Cnty

Mon 12/8

6:45 am-5:02 pm

1 stop7h 17m

$319

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 12/3

5:54 pm-10:28 pm

1 stop7h 34m

Santa Ana J. Wayne/Orange Cnty

Mon 12/8

11:10 am-10:30 pm

1 stop8h 20m

$363

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 12/3

5:54 pm-10:28 pm

1 stop7h 34m

Santa Ana J. Wayne/Orange Cnty

Mon 12/8

11:10 am-11:44 pm

2 stops9h 34m

$368

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 1/23

2:37 pm-8:03 pm

1 stop8h 26m

Santa Ana J. Wayne/Orange Cnty

Sun 1/25

9:20 pm-9:21 am

1 stop9h 01m

$437

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 4/19

2:40 pm-8:15 pm

1 stop8h 35m

Santa Ana J. Wayne/Orange Cnty

Fri 4/24

9:10 pm-11:40 am

2 stops11h 30m

$488

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santa Ana, California?

In general, February is the cheapest month to fly from Knoxville to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $313. If you aren’t able to travel during the month of February, then book flights to Santa Ana, California from Knoxville during September instead. Flights to Santa Ana, California in September, while not as cheap as those in February, still average around $313.

What is the cheapest day to depart on your flight to Santa Ana, California?

The cheapest day to depart from Knoxville to Santa Ana, California is on a Saturday. Travelers who choose to depart for Santa Ana, California on a Saturday will often find tickets for as low as $406. The most expensive day to fly to Santa Ana, California is Sunday, with ticket prices averaging around $715.

What is the cheapest time of day to depart on your flight to Santa Ana, California?

At noon is the cheapest time of day to fly from Knoxville to Santa Ana, California when you can find flight prices for as low as $388. Flying to Santa Ana, California at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Santa Ana, California is in the afternoon when prices are around $477.

How far in advance should I book a flight to Santa Ana, California?

You are more likely to see cheaper flights to Santa Ana, California from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $405 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from Knoxville for as low as $276 on momondo.

How have Knoxville to Santa Ana, California flight prices changed over time?

As of October 2025, prices for Knoxville to Santa Ana, California flights are approximately 11% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santa Ana, California (TYS to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santa Ana, California

Direct flights

None
There are no direct flights from Knoxville to Santa Ana, California. There are no popular flight routes from Knoxville to Santa Ana, California.
Search flight deals

  • How far is Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty by plane?

    Knoxville McGhee Tyson and Santa Ana J. Wayne/Orange Cnty are 1919.8 mi apart from one another. Typically, this will take 7h 29m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The required travel and health documents for your Santa Ana J. Wayne/Orange Cnty Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santa Ana, California?

Best airlines flying from Knoxville to Santa Ana, California

Compare and see reviews for airlines that fly from Knoxville to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $256Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights
American AirlinesPriceFrom $262Free CancellationRating
7.2
11,035 reviews
Search American Airlines flights
DeltaPriceFrom $282Free CancellationRating
7.9
7,998 reviews
Search Delta flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
Tustin

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santa Ana?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Santa Ana for you.

Can I find flights from Knoxville to Santa Ana with flexible booking policies on momondo?

Flights from Knoxville to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Santa Ana?

momondo provides multiple filters to help you find the best flight to Santa Ana from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Santa Ana right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Santa Ana flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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