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Cheap flights from Knoxville to McAllen from $319

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to McAllen departing on 9/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to McAllen

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:32 pm - 12:15 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
7h 43m1 stop Dallas/Fort Worth
American Airlines Logo
4:19 pm - 11:32 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
6h 13m1 stop Dallas/Fort Worth
$325American Airlines
Wed, Nov 18 - Fri, Nov 27
American Airlines Logo
6:03 am - 10:14 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
5h 11m1 stop Dallas/Fort Worth
American Airlines Logo
4:35 pm - 11:22 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
5h 47m1 stop Dallas/Fort Worth
$325American Airlines
Wed, Sep 2 - Wed, Sep 9
American Airlines Logo
6:03 am - 10:14 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
5h 11m1 stop Dallas/Fort Worth
American Airlines Logo
7:00 am - 1:53 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
5h 53m1 stop Dallas/Fort Worth
$326American Airlines
Wed, Sep 2 - Wed, Sep 9
United Airlines Logo
3:40 pm - 9:59 pmTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
7h 19m1 stop Houston George Bush Intcntl
United Airlines Logo
7:00 am - 1:20 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
5h 20m1 stop Houston George Bush Intcntl
$329United Airlines
Thu, Sep 3 - Sun, Sep 6
American Airlines Logo
6:03 am - 10:15 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
5h 12m1 stop Dallas/Fort Worth
American Airlines Logo
4:18 pm - 11:18 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
6h 00m1 stop Dallas/Fort Worth
$329American Airlines
Thu, Sep 3 - Sun, Sep 6
American Airlines Logo
5:30 am - 10:37 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
6h 07m1 stop Dallas/Fort Worth
American Airlines Logo
4:19 pm - 11:32 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
6h 13m1 stop Dallas/Fort Worth
$329American Airlines
Thu, Nov 19 - Fri, Nov 27
American Airlines Logo
5:19 pm - 12:15 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
7h 56m2 stops Charlotte Douglas Dallas/Fort Worth
American Airlines Logo
4:19 pm - 11:32 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
6h 13m1 stop Dallas/Fort Worth
$330American Airlines
Wed, Nov 18 - Fri, Nov 27
Delta Logo
10:28 am - 6:39 pmTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
9h 11m2 stops Atlanta Hartsfield-Jackson Austin Bergstrom
Delta Logo
12:39 pm - 10:27 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
8h 48m2 stops Austin Bergstrom Atlanta Hartsfield-Jackson
$331Delta
Wed, Sep 2 - Wed, Sep 9
United Airlines Logo
3:40 pm - 9:59 pmTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
7h 19m1 stop Houston George Bush Intcntl
United Airlines Logo
5:19 am - 4:58 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
10h 39m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$334United Airlines
Thu, Sep 3 - Sun, Sep 6
Delta Logo
7:30 am - 6:39 pmTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
12h 09m2 stops Atlanta Hartsfield-Jackson Austin Bergstrom
Delta Logo
12:39 pm - 11:14 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
9h 35m2 stops Austin Bergstrom Minneapolis St Paul
$335Delta
Wed, Sep 2 - Wed, Sep 9

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American Airlines flights from Knoxville to McAllen

Our best American Airlines deals on Knoxville to McAllen flight tickets
American Airlines
Sep 2
TYS6:03 amKnoxville McGhee Tyson
5h 11m
1 stop
MFE10:14 amMcAllen Miller Intl
Sep 9
MFE4:35 pmMcAllen Miller Intl
5h 47m
1 stop
TYS11:22 pmKnoxville McGhee Tyson
$325
American Airlines
Sep 2
TYS6:03 amKnoxville McGhee Tyson
5h 11m
1 stop
MFE10:14 amMcAllen Miller Intl
Sep 9
MFE7:00 amMcAllen Miller Intl
5h 53m
1 stop
TYS1:53 pmKnoxville McGhee Tyson
$326
American Airlines
Nov 18
TYS5:19 pmKnoxville McGhee Tyson
7h 56m
2 stops
MFE12:15 amMcAllen Miller Intl
Nov 27
MFE4:19 pmMcAllen Miller Intl
6h 13m
1 stop
TYS11:32 pmKnoxville McGhee Tyson
$330

United Airlines flights from Knoxville to McAllen

Our best United Airlines deals on Knoxville to McAllen flight tickets
United Airlines
Sep 3
TYS3:40 pmKnoxville McGhee Tyson
7h 19m
1 stop
MFE9:59 pmMcAllen Miller Intl
Sep 6
MFE7:00 amMcAllen Miller Intl
5h 20m
1 stop
TYS1:20 pmKnoxville McGhee Tyson
$329
United Airlines
Sep 3
TYS3:40 pmKnoxville McGhee Tyson
7h 19m
1 stop
MFE9:59 pmMcAllen Miller Intl
Sep 6
MFE5:19 amMcAllen Miller Intl
10h 39m
2 stops
TYS4:58 pmKnoxville McGhee Tyson
$334
United Airlines
Oct 31
TYS5:15 pmKnoxville McGhee Tyson
5h 43m
1 stop
MFE9:58 pmMcAllen Miller Intl
Nov 3
MFE5:00 amMcAllen Miller Intl
10h 59m
2 stops
TYS4:59 pmKnoxville McGhee Tyson
$416

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to McAllen that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 6, 2026.
Use the filters below to find and compare flights from Knoxville to McAllen that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleMcAllen

TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl

TYSMFE

Knoxville McGhee Tyson

Wed 11/18

5:32 pm-12:15 am

1 stop7h 43m

McAllen Miller Intl

Fri 11/27

4:19 pm-11:32 pm

1 stop6h 13m

$325
Quickest round-trip

KnoxvilleMcAllen

TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl

TYSMFE

Knoxville McGhee Tyson

Wed 9/2

6:03 am-10:14 am

1 stop5h 11m

McAllen Miller Intl

Wed 9/9

4:35 pm-11:22 pm

1 stop5h 47m

$325

KnoxvilleMcAllen

TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl

TYSMFE

Knoxville McGhee Tyson

Wed 9/2

6:03 am-10:14 am

1 stop5h 11m

McAllen Miller Intl

Wed 9/9

7:00 am-1:53 pm

1 stop5h 53m

$326

KnoxvilleMcAllen

TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl

TYSMFE

Knoxville McGhee Tyson

Thu 9/3

3:40 pm-9:59 pm

1 stop7h 19m

McAllen Miller Intl

Sun 9/6

7:00 am-1:20 pm

1 stop5h 20m

$329

KnoxvilleMcAllen

TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl

TYSMFE

Knoxville McGhee Tyson

Thu 9/3

6:03 am-10:15 am

1 stop5h 12m

McAllen Miller Intl

Sun 9/6

4:18 pm-11:18 pm

1 stop6h 00m

$329

KnoxvilleMcAllen

TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl

TYSMFE

Knoxville McGhee Tyson

Thu 11/19

5:30 am-10:37 am

1 stop6h 07m

McAllen Miller Intl

Fri 11/27

4:19 pm-11:32 pm

1 stop6h 13m

$329

KnoxvilleMcAllen

TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl

TYSMFE

Knoxville McGhee Tyson

Wed 11/18

5:19 pm-12:15 am

2 stops7h 56m

McAllen Miller Intl

Fri 11/27

4:19 pm-11:32 pm

1 stop6h 13m

$330

KnoxvilleMcAllen

TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl

TYSMFE

Knoxville McGhee Tyson

Wed 9/2

10:28 am-6:39 pm

2 stops9h 11m

McAllen Miller Intl

Wed 9/9

12:39 pm-10:27 pm

2 stops8h 48m

$331

KnoxvilleMcAllen

TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl

TYSMFE

Knoxville McGhee Tyson

Thu 9/3

3:40 pm-9:59 pm

1 stop7h 19m

McAllen Miller Intl

Sun 9/6

5:19 am-4:58 pm

2 stops10h 39m

$334

KnoxvilleMcAllen

TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl

TYSMFE

Knoxville McGhee Tyson

Wed 9/2

7:30 am-6:39 pm

2 stops12h 09m

McAllen Miller Intl

Wed 9/9

12:39 pm-11:14 pm

2 stops9h 35m

$335

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to McAllen

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Can stopping save me money on Knoxville to McAllen flights?

You could potentially save up to 53% on your flight if you consider stops on a Knoxville to McAllen flight.

When to book flights from Knoxville to McAllen

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to McAllen according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to McAllen (TYS to MFE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to McAllen

Fastest flight time

5h 43m

Direct flights

None
The fastest flight from Knoxville to McAllen takes 5h 43m
There are no direct flights from Knoxville to McAllen. There are no popular flight routes from Knoxville to McAllen.
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Frequently asked questions about flying from Knoxville to McAllen

  • How far is Knoxville McGhee Tyson to McAllen Miller Intl by plane?

    Knoxville McGhee Tyson and McAllen Miller Intl are 1079.4 mi apart from one another. A reasonable flight in good conditions will take 5h 43m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to McAllen Miller Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to McAllen Miller Intl Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to McAllen Miller Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to McAllen Miller Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to McAllen Miller Intl Airport.

  • What documentation or ID do you need to fly to McAllen Miller Intl Airport?

    The travel and health documents you'll need for your trip to McAllen Miller Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at McAllen Miller Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to McAllen?

Best airlines flying from Knoxville to McAllen

Compare and see reviews for airlines that fly from Knoxville to McAllen with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $278Free CancellationRating
7.1
11,867 reviews
Search American Airlines flights

Traveling to a place near McAllen?

Book flights to McAllen if you plan to visit one of these locations
Weslaco
Pharr
Edinburg
Mission

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to McAllen?

It is quick and easy to find Knoxville to McAllen flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to McAllen that suits you.

Can I find flights from Knoxville to McAllen with flexible booking policies on momondo?

momondo does allow users to show only those flights to McAllen from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to McAllen?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to McAllen from Knoxville.

I’m not ready to book a flight from Knoxville to McAllen right now. Can momondo alert me if prices change?

If you are simply researching potential flights to McAllen, momondo offers a useful price alert feature which will track prices for flights to McAllen from Knoxville and alert you when they change.

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