Cheap flights from Knoxville to Houston from $59

The month of October is, on average, the cheapest month to fly to Houston from Knoxville, with most prices found around $48. The month of December is another great option to travel to Houston, with average flight prices from Knoxville averaging around $50.

On average, the least expensive day to fly to Houston from Knoxville is on a Sunday. momondo users have found tickets for Sunday departures for as low as $94. However, this price may fluctuate depending on the airline, the season, and holidays. Be sure to avoid booking your departure on a Tuesday as prices are generally higher than usual. According to our data, the average ticket price to Houston on Tuesday is $194.

Our data shows that the cheapest Knoxville to Houston flights are usually those with departure times in the afternoon. Our users have found flights to Houston in the afternoon for as low as $460. Try not to purchase tickets in the morning because they tend to be around $501. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Knoxville McGhee Tyson to Houston Hobby for the best Knoxville McGhee Tyson - Houston flight prices

You are more likely to see cheaper flights to Houston from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Houston for around $305 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Houston from Knoxville for as low as $149 on momondo.

There are 4 cabin classes available to choose from on Knoxville to Houston flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Allegiant Air, Southwest, and American Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Houston

United Airlines, American Airlines and Delta are the top three most popular airlines that fly to Houston from Knoxville according to our data. United Airlines is the first choice among our users, with 39% of people opting to fly with this airline when traveling to Houston. Keep in mind that there are 4 different airlines that fly to Houston on a routine basis, so you have a few additional options to choose from.

As of May 2026, there are 5 flights per day flying from Knoxville to Houston. The most common time of day flights depart is 3:00PM, with 57% of flights taking off at noon.

As of May 2026, there are 35 flights per week flying from Knoxville to Houston. The most common day of the week flights depart is Mon, with 14% of flights taking off on this day.