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Cheap flights from Iowa to San Diego from $58

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to San Diego departing on 1/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Iowa to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
2:24 pm - 11:59 pmOMA-SAN
11h 35m1 stop
Frontier Logo
6:34 am - 1:31 pmSAN-OMA
4h 57m1 stop
$130Frontier
Find Deal
Thu, Dec 4 - Thu, Dec 11
Frontier Logo
7:58 pm - 11:59 pmDSM-SAN
6h 01m1 stop
Frontier Logo
6:34 am - 7:03 pmSAN-DSM
10h 29m1 stop
$131Frontier
Find Deal
Fri, Dec 5 - Mon, Dec 8
Multiple Airlines Logo
6:43 pm - 10:02 amMLI-SAN
17h 19m1 stop
Multiple Airlines Logo
6:25 am - 7:51 pmSAN-MLI
11h 26m1 stop
$205Multiple Airlines
Find Deal
Wed, Dec 10 - Sat, Dec 13
Multiple Airlines Logo
3:10 pm - 11:30 pmOMA-SAN
10h 20m2 stops
Multiple Airlines Logo
6:34 am - 1:31 pmSAN-OMA
4h 57m1 stop
$212Multiple Airlines
Find Deal
Wed, Dec 10 - Fri, Dec 12
American Airlines Logo
3:34 pm - 8:16 pmOMA-SAN
6h 42m1 stop
American Airlines Logo
6:15 am - 2:39 pmSAN-OMA
6h 24m1 stop
$232American Airlines
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Sat, Dec 6 - Sat, Dec 13
American Airlines Logo
6:00 am - 10:56 amMLI-SAN
6h 56m1 stop
American Airlines Logo
7:10 am - 3:27 pmSAN-MLI
6h 17m1 stop
$251American Airlines
Find Deal
Sat, Jan 10 - Wed, Jan 21
Delta Logo
5:50 pm - 11:48 pmOMA-SAN
7h 58m1 stop
Delta Logo
12:03 pm - 10:54 pmSAN-OMA
8h 51m1 stop
$259Delta
Find Deal
Mon, Mar 2 - Wed, Mar 4
United Airlines Logo
5:21 pm - 10:30 pmCID-SAN
7h 09m1 stop
United Airlines Logo
11:05 am - 8:36 pmSAN-CID
7h 31m2 stops
$264United Airlines
Find Deal
Wed, Dec 17 - Wed, Feb 25
United Airlines Logo
8:00 am - 3:04 pmCID-SAN
9h 04m2 stops
United Airlines Logo
11:05 am - 8:36 pmSAN-CID
7h 31m2 stops
$269United Airlines
Find Deal
Wed, Dec 17 - Wed, Feb 25
Delta Logo
5:06 pm - 10:47 pmMLI-SAN
7h 41m1 stop
Delta Logo
11:08 am - 10:32 pmSAN-MLI
9h 24m1 stop
$277Delta
Find Deal
Tue, Jan 13 - Wed, Jan 21

Frontier flights from Iowa to San Diego

Our best Frontier deals on Iowa to San Diego flight tickets
Frontier
Dec 4
OMA2:24 pmOmaha Eppley Airfield
11h 35m
1 stop
SAN11:59 pmSan Diego
Dec 11
SAN6:34 amSan Diego
4h 57m
1 stop
OMA1:31 pmOmaha Eppley Airfield
$130
Find similar
Frontier
Dec 5
DSM7:58 pmDes Moines
6h 01m
1 stop
SAN11:59 pmSan Diego
Dec 8
SAN6:34 amSan Diego
10h 29m
1 stop
DSM7:03 pmDes Moines
$131
Find similar
Frontier
Feb 23
OMA2:10 pmOmaha Eppley Airfield
11h 51m
1 stop
SAN12:01 amSan Diego
Feb 27
SAN6:25 amSan Diego
4h 50m
1 stop
OMA1:15 pmOmaha Eppley Airfield
$134
Find similar

American Airlines flights from Iowa to San Diego

Our best American Airlines deals on Iowa to San Diego flight tickets
American Airlines
Dec 6
OMA3:34 pmOmaha Eppley Airfield
6h 42m
1 stop
SAN8:16 pmSan Diego
Dec 13
SAN6:15 amSan Diego
6h 24m
1 stop
OMA2:39 pmOmaha Eppley Airfield
$232
Find similar
American Airlines
Jan 10
MLI6:00 amMoline Quad-City
6h 56m
1 stop
SAN10:56 amSan Diego
Jan 21
SAN7:10 amSan Diego
6h 17m
1 stop
MLI3:27 pmMoline Quad-City
$251
Find similar
American Airlines
Jan 10
MLI7:31 amMoline Quad-City
9h 32m
2 stops
SAN3:03 pmSan Diego
Jan 20
SAN1:19 pmSan Diego
6h 39m
1 stop
MLI9:58 pmMoline Quad-City
$256
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Iowa to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 9, 2025.
Use the filters below to find and compare flights from Iowa to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Thu 12/4

2:24 pm-11:59 pm

1 stop11h 35m

San Diego

Thu 12/11

6:34 am-1:31 pm

1 stop4h 57m

$130

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Fri 12/5

7:58 pm-11:59 pm

1 stop6h 01m

San Diego

Mon 12/8

6:34 am-7:03 pm

1 stop10h 29m

$131

MolineSan Diego

MLI - SAN

MLISAN

Moline Quad-City

Wed 12/10

6:43 pm-10:02 am

1 stop17h 19m

San Diego

Sat 12/13

6:25 am-7:51 pm

1 stop11h 26m

$205

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Wed 12/10

3:10 pm-11:30 pm

2 stops10h 20m

San Diego

Fri 12/12

6:34 am-1:31 pm

1 stop4h 57m

$212

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Sat 12/6

3:34 pm-8:16 pm

1 stop6h 42m

San Diego

Sat 12/13

6:15 am-2:39 pm

1 stop6h 24m

$232

MolineSan Diego

MLI - SAN

MLISAN

Moline Quad-City

Sat 1/10

6:00 am-10:56 am

1 stop6h 56m

San Diego

Wed 1/21

7:10 am-3:27 pm

1 stop6h 17m

$251

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Mon 3/2

5:50 pm-11:48 pm

1 stop7h 58m

San Diego

Wed 3/4

12:03 pm-10:54 pm

1 stop8h 51m

$259

Cedar RapidsSan Diego

CID - SAN

CIDSAN

Cedar Rapids

Wed 12/17

5:21 pm-10:30 pm

1 stop7h 09m

San Diego

Wed 2/25

11:05 am-8:36 pm

2 stops7h 31m

$264

Cedar RapidsSan Diego

CID - SAN

CIDSAN

Cedar Rapids

Wed 12/17

8:00 am-3:04 pm

2 stops9h 04m

San Diego

Wed 2/25

11:05 am-8:36 pm

2 stops7h 31m

$269

MolineSan Diego

MLI - SAN

MLISAN

Moline Quad-City

Tue 1/13

5:06 pm-10:47 pm

1 stop7h 41m

San Diego

Wed 1/21

11:08 am-10:32 pm

1 stop9h 24m

$277

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Iowa to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of June, then departing from Iowa during the month August is also very affordable. Most momondo users find prices during this month for around $282.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Iowa to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $161. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $468. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $170. Flights in the morning are often more expensive with an average ticket price of $433.

What is the cheapest Iowa to San Diego flight route?

Fly from Des Moines to San Diego for the best Iowa - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Iowa when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $375 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Iowa for as low as $264 on momondo.

What cabin class options are available on Iowa to San Diego flights?

There is only 1 cabin class available to choose from on Iowa to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Iowa to San Diego flights?

No. A direct flight is the cheapest option for a flight between Iowa to San Diego.

Cheap Iowa to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to San Diego

Fastest flight time

3h 25m

Direct flights

Mon, Sat and Sun

Airports in San Diego

1 airport
The fastest flight from Iowa to San Diego takes 3h 25m
Direct flights go from Iowa to San Diego on Monday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport near San Diego: San Diego (SAN)
Search flight deals

  • When did momondo last update prices for flights from Iowa to San Diego Airport?

    Prices for flights from Iowa to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Iowa to San Diego Airport?

  • How old do you have to be to fly from Iowa to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Iowa to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Iowa to San Diego?

Best airlines flying from Iowa to San Diego

Compare and see reviews for airlines that fly from Iowa to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $104Free CancellationRating
7.2
697 reviews
Search Allegiant Air flights
FrontierPriceFrom $119Free CancellationRating
5.8
3,111 reviews
Search Frontier flights
American AirlinesPriceFrom $246Free CancellationRating
7.2
11,046 reviews
Search American Airlines flights
United AirlinesPriceFrom $253Free CancellationRating
7.4
9,014 reviews
Search United Airlines flights
DeltaPriceFrom $256Free CancellationRating
7.9
8,001 reviews
Search Delta flights
SouthwestPriceFrom $326Free CancellationRating
8.0
4,238 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Imperial Beach
La Mesa
Poway
Borrego Springs
San Ysidro
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Iowa to San Diego for you.

Can I find flights from Iowa to San Diego with flexible booking policies on momondo?

Yes. All flights to San Diego from Iowa on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Iowa to San Diego?

momondo provides multiple filters to help you find the best flight to San Diego from Iowa. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Iowa to San Diego right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Diego, momondo offers a useful price alert feature which will track prices for flights to San Diego from Iowa and alert you when they change.

An easier way to manage your San Diego trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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