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Cheap flights from Iowa to San Diego from $57

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to San Diego departing on 3/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Iowa to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:17 pm - 12:08 am
DSM
-
SAN
6h 51m1 stop
Frontier Logo
6:25 am - 7:04 pm
SAN
-
DSM
10h 39m1 stop
$112Frontier
Fri, Feb 20 - Fri, Feb 27
Frontier Logo
7:17 pm - 12:08 am
DSM
-
SAN
6h 51m1 stop
Frontier Logo
6:25 am - 6:42 pm
SAN
-
DSM
10h 17m1 stop
$127Frontier
Mon, Feb 23 - Thu, Feb 26
Multiple Airlines Logo
5:00 pm - 9:41 pm
OMA
-
SAN
6h 41m1 stop
Multiple Airlines Logo
2:52 pm - 11:43 am
SAN
-
OMA
18h 51m1 stop
$175Multiple Airlines
Wed, Feb 25 - Sun, Mar 1
Multiple Airlines Logo
8:07 pm - 9:41 pm
CID
-
SAN
27h 34m1 stop
Multiple Airlines Logo
2:08 pm - 1:37 pm
SAN
-
CID
21h 29m1 stop
$182Multiple Airlines
Mon, Mar 2 - Tue, Mar 10
American Airlines Logo
3:58 pm - 10:50 pm
MLI
-
SAN
8h 52m1 stop
American Airlines Logo
6:20 am - 3:27 pm
SAN
-
MLI
7h 07m1 stop
$251American Airlines
Wed, Jan 28 - Tue, Feb 3
American Airlines Logo
3:58 pm - 10:50 pm
MLI
-
SAN
8h 52m1 stop
American Airlines Logo
10:09 am - 10:26 pm
SAN
-
MLI
10h 17m2 stops
$256American Airlines
Wed, Jan 28 - Tue, Feb 3
Delta Logo
5:51 am - 12:55 pm
MLI
-
SAN
9h 04m1 stop
Delta Logo
6:30 am - 4:16 pm
SAN
-
MLI
7h 46m1 stop
$277Delta
Sat, Feb 7 - Wed, Feb 18
United Airlines Logo
10:46 am - 3:39 pm
MLI
-
SAN
6h 53m1 stop
United Airlines Logo
10:59 am - 7:02 pm
SAN
-
MLI
6h 03m1 stop
$280United Airlines
Thu, Feb 26 - Tue, Mar 3
United Airlines Logo
10:46 am - 5:29 pm
MLI
-
SAN
8h 43m2 stops
United Airlines Logo
10:59 am - 7:02 pm
SAN
-
MLI
6h 03m1 stop
$285United Airlines
Thu, Feb 26 - Tue, Mar 3
Delta Logo
5:51 am - 12:55 pm
MLI
-
SAN
9h 04m1 stop
Delta Logo
6:30 am - 4:16 pm
SAN
-
MLI
7h 46m1 stop
$293Delta
Sat, Feb 7 - Sat, Feb 14

American Airlines flights from Iowa to San Diego

Our best American Airlines deals on Iowa to San Diego flight tickets
American Airlines
Feb 4
DSM5:01 pmDes Moines
7h 25m
1 stop
SAN10:26 pmSan Diego
Feb 11
SAN12:40 pmSan Diego
8h 28m
1 stop
DSM11:08 pmDes Moines
$223
American Airlines
Jan 28
MLI3:58 pmMoline Quad-City
8h 52m
1 stop
SAN10:50 pmSan Diego
Feb 3
SAN6:20 amSan Diego
7h 07m
1 stop
MLI3:27 pmMoline Quad-City
$251
American Airlines
Jan 28
MLI3:58 pmMoline Quad-City
8h 52m
1 stop
SAN10:50 pmSan Diego
Feb 3
SAN10:09 amSan Diego
10h 17m
2 stops
MLI10:26 pmMoline Quad-City
$256

Southwest flights from Iowa to San Diego

Our best Southwest deals on Iowa to San Diego flight tickets
Southwest
Apr 7
DSM6:55 amDes Moines
7h 15m
2 stops
SAN12:10 pmSan Diego
Apr 15
SAN6:35 amSan Diego
5h 30m
1 stop
DSM2:05 pmDes Moines
$228
Southwest
Apr 7
DSM6:55 amDes Moines
7h 45m
2 stops
SAN12:40 pmSan Diego
Apr 15
SAN10:05 amSan Diego
9h 10m
2 stops
DSM9:15 pmDes Moines
$234
Southwest
Mar 11
OMA12:20 pmOmaha Eppley Airfield
11h 25m
2 stops
SAN9:45 pmSan Diego
Mar 23
SAN4:20 pmSan Diego
6h 30m
1 stop
OMA12:50 amOmaha Eppley Airfield
$273

momondo Fare Finder

 
Customize your flight search to find flights from Iowa to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Iowa to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Fri 2/20

7:17 pm-12:08 am

1 stop6h 51m

San Diego

Fri 2/27

6:25 am-7:04 pm

1 stop10h 39m

$112

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 2/23

7:17 pm-12:08 am

1 stop6h 51m

San Diego

Thu 2/26

6:25 am-6:42 pm

1 stop10h 17m

$127

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Wed 2/25

5:00 pm-9:41 pm

1 stop6h 41m

San Diego

Sun 3/1

2:52 pm-11:43 am

1 stop18h 51m

$175

Cedar RapidsSan Diego

CID - SAN

CIDSAN

Cedar Rapids

Mon 3/2

8:07 pm-9:41 pm

1 stop27h 34m

San Diego

Tue 3/10

2:08 pm-1:37 pm

1 stop21h 29m

$182

MolineSan Diego

MLI - SAN

MLISAN

Moline Quad-City

Wed 1/28

3:58 pm-10:50 pm

1 stop8h 52m

San Diego

Tue 2/3

6:20 am-3:27 pm

1 stop7h 07m

$251

MolineSan Diego

MLI - SAN

MLISAN

Moline Quad-City

Wed 1/28

3:58 pm-10:50 pm

1 stop8h 52m

San Diego

Tue 2/3

10:09 am-10:26 pm

2 stops10h 17m

$256

MolineSan Diego

MLI - SAN

MLISAN

Moline Quad-City

Sat 2/7

5:51 am-12:55 pm

1 stop9h 04m

San Diego

Wed 2/18

6:30 am-4:16 pm

1 stop7h 46m

$277

MolineSan Diego

MLI - SAN

MLISAN

Moline Quad-City

Thu 2/26

10:46 am-3:39 pm

1 stop6h 53m

San Diego

Tue 3/3

10:59 am-7:02 pm

1 stop6h 03m

$280

MolineSan Diego

MLI - SAN

MLISAN

Moline Quad-City

Thu 2/26

10:46 am-5:29 pm

2 stops8h 43m

San Diego

Tue 3/3

10:59 am-7:02 pm

1 stop6h 03m

$285

MolineSan Diego

MLI - SAN

MLISAN

Moline Quad-City

Sat 2/7

5:51 am-12:55 pm

1 stop9h 04m

San Diego

Sat 2/14

6:30 am-4:16 pm

1 stop7h 46m

$293

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Iowa to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of June, then departing from Iowa during the month August is also very affordable. Most momondo users find prices during this month for around $282.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Iowa to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $161. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $179. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest Iowa to San Diego flight route?

Fly from Des Moines to San Diego for the best Iowa - San Diego flight prices

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Iowa when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $363 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Iowa for as low as $272 on momondo.

What cabin class options are available on Iowa to San Diego flights?

There is only 1 cabin class available to choose from on Iowa to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Iowa to San Diego flights?

No. A direct flight is the cheapest option for a flight between Iowa to San Diego.

Cheap Iowa to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to San Diego

Fastest flight time

3h 10m

Direct flights

Mon, Tue, Fri, Sat and Sun

Airports in San Diego

1 airport
The fastest flight from Iowa to San Diego takes 3h 10m
Direct flights go from Iowa to San Diego on Monday, Tuesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in San Diego. From Iowa there are direct flights to San Diego (SAN).
Search flight deals

  • When did momondo last update prices for flights from Iowa to San Diego Airport?

    Prices for flights from Iowa to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Iowa to San Diego Airport?

  • How old do you have to be to fly from Iowa to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Iowa to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The required travel and health documents for your San Diego Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at San Diego Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Iowa to San Diego?

Best airlines flying from Iowa to San Diego

Compare and see reviews for airlines that fly from Iowa to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $104Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
FrontierPriceFrom $116Free CancellationRating
5.7
3,061 reviews
Search Frontier flights
DeltaPriceFrom $148Free CancellationRating
7.9
8,032 reviews
Search Delta flights
American AirlinesPriceFrom $228Free CancellationRating
7.2
11,097 reviews
Search American Airlines flights
United AirlinesPriceFrom $253Free CancellationRating
7.4
9,143 reviews
Search United Airlines flights
SouthwestPriceFrom $303Free CancellationRating
8.0
4,250 reviews
Search Southwest flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
Poway
National City
Imperial Beach
Borrego Springs
La Mesa
San Ysidro
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to San Diego?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Iowa to San Diego for you.

Can I find flights from Iowa to San Diego with flexible booking policies on momondo?

Yes. All flights to San Diego from Iowa on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Iowa to San Diego?

momondo provides multiple filters to help you find the best flight to San Diego from Iowa. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Iowa to San Diego right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Diego, momondo offers a useful price alert feature which will track prices for flights to San Diego from Iowa and alert you when they change.

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