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Cheap flights from Florence, South Carolina to Los Angeles from $520

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to Los Angeles departing on 11/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florence, South Carolina to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:15 am - 12:37 pmFLO-SNA
9h 22m2 stops
American Airlines Logo
7:45 am - 6:07 pmSNA-FLO
7h 22m1 stop
$556American Airlines
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Wed, Nov 5 - Sun, Nov 9
American Airlines Logo
6:15 am - 3:20 pmFLO-SNA
12h 05m2 stops
American Airlines Logo
7:35 pm - 9:54 amSNA-FLO
11h 19m2 stops
$561American Airlines
Find Deal
Wed, Nov 5 - Sun, Nov 9
American Airlines Logo
10:29 am - 6:24 pmFLO-SNA
10h 55m2 stops
American Airlines Logo
8:30 am - 10:53 pmSNA-FLO
11h 23m2 stops
$669American Airlines
Find Deal
Fri, Nov 7 - Tue, Nov 11
American Airlines Logo
6:15 am - 7:57 pmFLO-SNA
16h 42m1 stop
American Airlines Logo
7:45 am - 6:07 pmSNA-FLO
7h 22m1 stop
$964American Airlines
Find Deal
Wed, Nov 5 - Sun, Nov 9
American Airlines Logo
10:29 am - 7:57 pmFLO-SNA
12h 28m1 stop
American Airlines Logo
6:45 am - 10:53 pmSNA-FLO
13h 08m2 stops
$1,002American Airlines
Find Deal
Fri, Nov 7 - Tue, Nov 11
American Airlines Logo
6:15 am - 7:57 pmFLO-SNA
16h 42m1 stop
American Airlines Logo
8:55 am - 10:53 pmSNA-FLO
10h 58m1 stop
$1,111American Airlines
Find Deal
Fri, Nov 7 - Tue, Nov 11

American Airlines flights from Florence, South Carolina to Santa Ana, California

Our best American Airlines deals on Florence, South Carolina to Santa Ana, California flight tickets
American Airlines
Nov 5
FLO6:15 amFlorence
9h 22m
2 stops
SNA12:37 pmSanta Ana J. Wayne/Orange Cnty
Nov 9
SNA7:45 amSanta Ana J. Wayne/Orange Cnty
7h 22m
1 stop
FLO6:07 pmFlorence
$556
Find similar
American Airlines
Nov 5
FLO6:15 amFlorence
12h 05m
2 stops
SNA3:20 pmSanta Ana J. Wayne/Orange Cnty
Nov 9
SNA7:35 pmSanta Ana J. Wayne/Orange Cnty
11h 19m
2 stops
FLO9:54 amFlorence
$561
Find similar
American Airlines
Nov 7
FLO10:29 amFlorence
10h 55m
2 stops
SNA6:24 pmSanta Ana J. Wayne/Orange Cnty
Nov 11
SNA8:30 amSanta Ana J. Wayne/Orange Cnty
11h 23m
2 stops
FLO10:53 pmFlorence
$669
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to Santa Ana, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from Florence, South Carolina to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Wed 11/5

6:15 am-12:37 pm

2 stops9h 22m

Santa Ana J. Wayne/Orange Cnty

Sun 11/9

7:45 am-6:07 pm

1 stop7h 22m

$556

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Wed 11/5

6:15 am-3:20 pm

2 stops12h 05m

Santa Ana J. Wayne/Orange Cnty

Sun 11/9

7:35 pm-9:54 am

2 stops11h 19m

$561

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Fri 11/7

10:29 am-6:24 pm

2 stops10h 55m

Santa Ana J. Wayne/Orange Cnty

Tue 11/11

8:30 am-10:53 pm

2 stops11h 23m

$669

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Wed 11/5

6:15 am-7:57 pm

1 stop16h 42m

Santa Ana J. Wayne/Orange Cnty

Sun 11/9

7:45 am-6:07 pm

1 stop7h 22m

$964

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Fri 11/7

10:29 am-7:57 pm

1 stop12h 28m

Santa Ana J. Wayne/Orange Cnty

Tue 11/11

6:45 am-10:53 pm

2 stops13h 08m

$1,002

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Fri 11/7

6:15 am-7:57 pm

1 stop16h 42m

Santa Ana J. Wayne/Orange Cnty

Tue 11/11

8:55 am-10:53 pm

1 stop10h 58m

$1,111

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Sat 11/29

5:15 am-11:37 am

2 stops9h 22m

$520

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Mon 12/1

6:33 pm-10:50 am

2 stops19h 17m

$586

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Sun 11/30

5:15 am-3:22 pm

2 stops13h 07m

$767

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Mon 12/1

6:33 pm-7:57 pm

1 stop28h 24m

$832

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Florence, South Carolina to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Florence to Santa Ana J. Wayne/Orange Cnty?

American Airlines is the most popular carrier operating from Florence to Santa Ana J. Wayne/Orange Cnty

What airlines fly to Santa Ana, California?

American Airlines, Delta and Spirit Airlines are the top three most popular airlines that fly to Santa Ana, California from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 72% of people opting to fly with this airline when traveling to Santa Ana, California. Keep in mind that there are 8 different airlines that fly to Santa Ana, California on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to Santa Ana, California (FLO to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to Santa Ana, California

Direct flights

None
There are no direct flights from Florence, South Carolina to Santa Ana, California. There are no popular flight routes from Florence, South Carolina to Santa Ana, California.
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  • How far is Florence to Santa Ana J. Wayne/Orange Cnty by plane?

    Florence and Santa Ana J. Wayne/Orange Cnty are 2169.2 mi apart from one another. A reasonable flight in good conditions will take 9h 22m.

  • When did momondo last update prices for flights from Florence Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Florence Airport to Santa Ana J. Wayne/Orange Cnty Airport were last updated today.

  • How old do you have to be to fly from Florence Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The travel and health documents required for your trip to Santa Ana J. Wayne/Orange Cnty Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santa Ana J. Wayne/Orange Cnty Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
Tustin

Why use momondo?

Why should I use momondo to find a flight deal from Florence to Santa Ana?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Florence to Santa Ana. momondo saves you time and could save you money on your trip.

Can I find flights from Florence to Santa Ana with flexible booking policies on momondo?

Flights from Florence to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Florence to Santa Ana?

momondo helps you find the best flight between Florence and Santa Ana by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Florence to Santa Ana right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Florence to Santa Ana now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santa Ana and let you know when they change.

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