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Cheap flights from Florence, South Carolina to Los Angeles from $628

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to Los Angeles departing on 5/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florence, South Carolina to Los Angeles

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:35 pm - 8:05 pm
FLO
-
SNA
8h 30m
1 stop
American Airlines Logo
8:00 am - 10:00 pm
SNA
-
FLO
11h 00m
2 stops
$628American Airlines
Fri, May 22 - Tue, May 26
American Airlines Logo
2:35 pm - 10:01 pm
FLO
-
SNA
10h 26m
2 stops
American Airlines Logo
8:00 am - 10:00 pm
SNA
-
FLO
11h 00m
2 stops
$704American Airlines
Fri, May 22 - Tue, May 26
American Airlines Logo
2:35 pm - 8:05 pm
FLO
-
SNA
8h 30m
1 stop
American Airlines Logo
7:15 am - 10:00 pm
SNA
-
FLO
11h 45m
1 stop
$1,065American Airlines
Fri, May 22 - Tue, May 26

American Airlines flights from Florence, South Carolina to Santa Ana, California

Our best American Airlines deals on Florence, South Carolina to Santa Ana, California flight tickets
American Airlines
May 22
FLO2:35 pmFlorence
8h 30m
1 stop
SNA8:05 pmSanta Ana J. Wayne/Orange Cnty
May 26
SNA8:00 amSanta Ana J. Wayne/Orange Cnty
11h 00m
2 stops
FLO10:00 pmFlorence
$628
American Airlines
May 22
FLO2:35 pmFlorence
10h 26m
2 stops
SNA10:01 pmSanta Ana J. Wayne/Orange Cnty
May 26
SNA8:00 amSanta Ana J. Wayne/Orange Cnty
11h 00m
2 stops
FLO10:00 pmFlorence
$704
American Airlines
May 22
FLO2:35 pmFlorence
8h 30m
1 stop
SNA8:05 pmSanta Ana J. Wayne/Orange Cnty
May 26
SNA7:15 amSanta Ana J. Wayne/Orange Cnty
11h 45m
1 stop
FLO10:00 pmFlorence
$1,065

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to Santa Ana, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Fri 5/22

2:35 pm-8:05 pm

1 stop8h 30m

Santa Ana J. Wayne/Orange Cnty

Tue 5/26

8:00 am-10:00 pm

2 stops11h 00m

$628

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Fri 5/22

2:35 pm-10:01 pm

2 stops10h 26m

Santa Ana J. Wayne/Orange Cnty

Tue 5/26

8:00 am-10:00 pm

2 stops11h 00m

$704

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Fri 5/22

2:35 pm-8:05 pm

1 stop8h 30m

Santa Ana J. Wayne/Orange Cnty

Tue 5/26

7:15 am-10:00 pm

1 stop11h 45m

$1,065

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Los Angeles from

How to get the cheapest flight ticket from Florence, South Carolina to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Santa Ana, California?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Santa Ana, California from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 76% of people opting to fly with this airline when traveling to Santa Ana, California. Keep in mind that there are 8 different airlines that fly to Santa Ana, California on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to Santa Ana, California (FLO to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to Santa Ana, California

Fastest flight time

8h 30m

Direct flights

None
The fastest flight from Florence, South Carolina to Santa Ana, California takes 8h 30m
There are no direct flights from Florence, South Carolina to Santa Ana, California. There are no popular flight routes from Florence, South Carolina to Santa Ana, California.
Search flight deals

Frequently asked questions about flying from Florence, South Carolina to Santa Ana, California

  • How far is Florence to Santa Ana J. Wayne/Orange Cnty by plane?

    Florence and Santa Ana J. Wayne/Orange Cnty are 2169.2 mi apart from one another. A reasonable flight in good conditions will take 8h 30m.

  • When did momondo last update prices for flights from Florence Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Florence Airport to Santa Ana J. Wayne/Orange Cnty Airport were last updated today.

  • How old do you have to be to fly from Florence Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The travel and health documents required for your trip to Santa Ana J. Wayne/Orange Cnty Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santa Ana J. Wayne/Orange Cnty Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
Tustin

Why use momondo?

Why should I use momondo to find a flight deal from Florence to Santa Ana?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Florence to Santa Ana. momondo saves you time and could save you money on your trip.

Can I find flights from Florence to Santa Ana with flexible booking policies on momondo?

Flights from Florence to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Florence to Santa Ana?

momondo helps you find the best flight between Florence and Santa Ana by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Florence to Santa Ana right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Florence to Santa Ana now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santa Ana and let you know when they change.

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