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Cheap flights from Florence, South Carolina to San Diego from $322

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to San Diego departing on 5/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Florence, South Carolina to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:35 pm - 6:47 pm
FLO
-
SAN
7h 12m
1 stop
American Airlines Logo
6:25 am - 10:00 pm
SAN
-
FLO
12h 35m
2 stops
$577American Airlines
Tue, Jun 23 - Tue, Jun 30
American Airlines Logo
2:35 pm - 10:39 pm
FLO
-
SAN
11h 04m
2 stops
American Airlines Logo
6:25 am - 10:00 pm
SAN
-
FLO
12h 35m
2 stops
$583American Airlines
Tue, Jun 23 - Tue, Jun 30
American Airlines Logo
5:05 am - 9:04 am
FLO
-
SAN
6h 59m
1 stop
American Airlines Logo
6:15 am - 10:00 pm
SAN
-
FLO
12h 45m
2 stops
$623American Airlines
Fri, May 29 - Mon, Jun 1
American Airlines Logo
5:05 am - 9:04 am
FLO
-
SAN
6h 59m
1 stop
American Airlines Logo
7:15 am - 10:00 pm
SAN
-
FLO
11h 45m
2 stops
$624American Airlines
Sat, May 23 - Wed, May 27
American Airlines Logo
2:35 pm - 11:59 pm
FLO
-
SAN
12h 24m
2 stops
American Airlines Logo
6:15 am - 10:00 pm
SAN
-
FLO
12h 45m
2 stops
$628American Airlines
Fri, May 29 - Mon, Jun 1
American Airlines Logo
5:05 am - 12:11 pm
FLO
-
SAN
10h 06m
2 stops
American Airlines Logo
8:05 am - 10:00 pm
SAN
-
FLO
10h 55m
2 stops
$629American Airlines
Sat, May 23 - Wed, May 27
American Airlines Logo
5:05 am - 9:04 am
FLO
-
SAN
6h 59m
1 stop
American Airlines Logo
8:05 am - 10:00 pm
SAN
-
FLO
10h 55m
2 stops
$728American Airlines
Thu, May 21 - Sun, May 24
American Airlines Logo
5:05 am - 2:20 pm
FLO
-
SAN
12h 15m
2 stops
American Airlines Logo
7:15 am - 10:00 pm
SAN
-
FLO
11h 45m
2 stops
$757American Airlines
Thu, May 21 - Sun, May 24
American Airlines Logo
2:35 pm - 6:47 pm
FLO
-
SAN
7h 12m
1 stop
American Airlines Logo
9:25 pm - 2:10 pm
SAN
-
FLO
13h 45m
1 stop
$767American Airlines
Fri, May 29 - Mon, Jun 1
American Airlines Logo
2:35 pm - 9:48 pm
FLO
-
SAN
10h 13m
1 stop
American Airlines Logo
9:25 pm - 10:00 pm
SAN
-
FLO
21h 35m
1 stop
$821American Airlines
Tue, Jun 23 - Tue, Jun 30

American Airlines flights from Florence, South Carolina to San Diego

Our best American Airlines deals on Florence, South Carolina to San Diego flight tickets
American Airlines
Jun 23
FLO2:35 pmFlorence
7h 12m
1 stop
SAN6:47 pmSan Diego
Jun 30
SAN6:25 amSan Diego
12h 35m
2 stops
FLO10:00 pmFlorence
$577
American Airlines
Jun 23
FLO2:35 pmFlorence
11h 04m
2 stops
SAN10:39 pmSan Diego
Jun 30
SAN6:25 amSan Diego
12h 35m
2 stops
FLO10:00 pmFlorence
$583
American Airlines
May 29
FLO5:05 amFlorence
6h 59m
1 stop
SAN9:04 amSan Diego
Jun 1
SAN6:15 amSan Diego
12h 45m
2 stops
FLO10:00 pmFlorence
$623

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 8, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Tue 6/23

2:35 pm-6:47 pm

1 stop7h 12m

San Diego

Tue 6/30

6:25 am-10:00 pm

2 stops12h 35m

$577

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Tue 6/23

2:35 pm-10:39 pm

2 stops11h 04m

San Diego

Tue 6/30

6:25 am-10:00 pm

2 stops12h 35m

$583

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Fri 5/29

5:05 am-9:04 am

1 stop6h 59m

San Diego

Mon 6/1

6:15 am-10:00 pm

2 stops12h 45m

$623

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Sat 5/23

5:05 am-9:04 am

1 stop6h 59m

San Diego

Wed 5/27

7:15 am-10:00 pm

2 stops11h 45m

$624

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Fri 5/29

2:35 pm-11:59 pm

2 stops12h 24m

San Diego

Mon 6/1

6:15 am-10:00 pm

2 stops12h 45m

$628

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Sat 5/23

5:05 am-12:11 pm

2 stops10h 06m

San Diego

Wed 5/27

8:05 am-10:00 pm

2 stops10h 55m

$629
Quickest round-trip

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Thu 5/21

5:05 am-9:04 am

1 stop6h 59m

San Diego

Sun 5/24

8:05 am-10:00 pm

2 stops10h 55m

$728

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Thu 5/21

5:05 am-2:20 pm

2 stops12h 15m

San Diego

Sun 5/24

7:15 am-10:00 pm

2 stops11h 45m

$757

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Fri 5/29

2:35 pm-6:47 pm

1 stop7h 12m

San Diego

Mon 6/1

9:25 pm-2:10 pm

1 stop13h 45m

$767

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Tue 6/23

2:35 pm-9:48 pm

1 stop10h 13m

San Diego

Tue 6/30

9:25 pm-10:00 pm

1 stop21h 35m

$821

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Florence, South Carolina to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Florence to San Diego?

American Airlines is the most popular carrier operating from Florence to San Diego

What airlines fly to San Diego?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to San Diego from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 73% of people opting to fly with this airline when traveling to San Diego. Keep in mind that there are 7 different airlines that fly to San Diego on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to San Diego (FLO to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to San Diego

Fastest flight time

7h 12m

Direct flights

None
The fastest flight from Florence, South Carolina to San Diego takes 7h 12m
There are no direct flights from Florence, South Carolina to San Diego. There are no popular flight routes from Florence, South Carolina to San Diego.
Search flight deals

Frequently asked questions about flying from Florence, South Carolina to San Diego

  • How far is Florence to San Diego by plane?

    Florence and San Diego are 2144.5 mi apart from one another. A reasonable flight in good conditions will take 7h 12m.

  • When did momondo last update prices for flights from Florence Airport to San Diego Airport?

    Prices for flights from Florence Airport to San Diego Airport refresh daily.

  • How old do you have to be to fly from Florence Airport to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Florence Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents required for your trip to San Diego Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Diego Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
San Ysidro
La Mesa
Imperial Beach
Borrego Springs
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Florence to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Florence to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Florence to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Florence with this policy.

How can momondo help me find flights from Florence to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Florence.

I’m not ready to book a flight from Florence to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Florence to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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