$634 Cheap Flights from Florence, South Carolina to San Diego in 2026 | momondo

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Find the cheapest flights from Florence, South Carolina to San Diego

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2:34 pm - 9:37 pmFLO Florence-SAN San Diego

10h 03m1 stop Charlotte Douglas

11:58 am - 11:57 pmSAN San Diego-FLO Florence

8h 59m1 stop Charlotte Douglas

$634American Airlines

Fri, Oct 9 - Wed, Oct 14

2:34 pm - 9:37 pmFLO Florence-SAN San Diego

10h 03m1 stop Charlotte Douglas

11:58 am - 11:57 pmSAN San Diego-FLO Florence

8h 59m1 stop Charlotte Douglas

$654American Airlines

Fri, Oct 9 - Wed, Oct 14

5:09 am - 3:32 pmFLO Florence-SAN San Diego

13h 23m2 stops Charlotte Douglas Phoenix Sky Harbor Intl

11:58 am - 11:57 pmSAN San Diego-FLO Florence

8h 59m1 stop Charlotte Douglas

$668American Airlines

Fri, Oct 9 - Wed, Oct 14

2:34 pm - 9:37 pmFLO Florence-SAN San Diego

10h 03m1 stop Charlotte Douglas

11:58 am - 11:57 pmSAN San Diego-FLO Florence

8h 59m1 stop Charlotte Douglas

$681American Airlines

Fri, Oct 9 - Wed, Oct 14

2:34 pm - 9:37 pmFLO Florence-SAN San Diego

10h 03m1 stop Charlotte Douglas

11:58 am - 11:57 pmSAN San Diego-FLO Florence

8h 59m1 stop Charlotte Douglas

$701American Airlines

Fri, Oct 9 - Wed, Oct 14

2:34 pm - 7:00 pmFLO Florence-SAN San Diego

7h 26m1 stop Charlotte Douglas

10:40 pm - 2:09 pmSAN San Diego-FLO Florence

12h 29m2 stops Chicago O'Hare Intl Charlotte Douglas

$722American Airlines

Fri, Oct 9 - Wed, Oct 14

2:34 pm - 7:00 pmFLO Florence-SAN San Diego

7h 26m1 stop Charlotte Douglas

10:40 pm - 2:09 pmSAN San Diego-FLO Florence

12h 29m2 stops Chicago O'Hare Intl Charlotte Douglas

$742American Airlines

Fri, Oct 9 - Wed, Oct 14

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American Airlines flights from Florence, South Carolina to San Diego

Our best American Airlines deals on Florence, South Carolina to San Diego flight tickets

American Airlines

Oct 9

FLO2:34 pmFlorence

10h 03m

1 stop

SAN9:37 pmSan Diego

Oct 14

SAN11:58 amSan Diego

8h 59m

1 stop

FLO11:57 pmFlorence

$634

American Airlines

Oct 9

FLO2:34 pmFlorence

10h 03m

1 stop

SAN9:37 pmSan Diego

Oct 14

SAN11:58 amSan Diego

8h 59m

1 stop

FLO11:57 pmFlorence

$654

American Airlines

Oct 9

FLO5:09 amFlorence

13h 23m

2 stops

SAN3:32 pmSan Diego

Oct 14

SAN11:58 amSan Diego

8h 59m

1 stop

FLO11:57 pmFlorence

$668

momondo Fare Finder

Use the filters below to find and compare flights from Florence, South Carolina to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

FlorenceSan Diego

FLO Florence - SAN San Diego

FLOSAN

Florence

Fri 10/9

2:34 pm-9:37 pm

1 stop10h 03m

San Diego

Wed 10/14

11:58 am-11:57 pm

1 stop8h 59m

$634

FlorenceSan Diego

FLO Florence - SAN San Diego

FLOSAN

Florence

Fri 10/9

2:34 pm-9:37 pm

1 stop10h 03m

San Diego

Wed 10/14

11:58 am-11:57 pm

1 stop8h 59m

$654

FlorenceSan Diego

FLO Florence - SAN San Diego

FLOSAN

Florence

Fri 10/9

5:09 am-3:32 pm

2 stops13h 23m

San Diego

Wed 10/14

11:58 am-11:57 pm

1 stop8h 59m

$668

FlorenceSan Diego

FLO Florence - SAN San Diego

FLOSAN

Florence

Fri 10/9

2:34 pm-9:37 pm

1 stop10h 03m

San Diego

Wed 10/14

11:58 am-11:57 pm

1 stop8h 59m

$681

FlorenceSan Diego

FLO Florence - SAN San Diego

FLOSAN

Florence

Fri 10/9

2:34 pm-9:37 pm

1 stop10h 03m

San Diego

Wed 10/14

11:58 am-11:57 pm

1 stop8h 59m

$701

FlorenceSan Diego

FLO Florence - SAN San Diego

FLOSAN

Florence

Fri 10/9

2:34 pm-7:00 pm

1 stop7h 26m

San Diego

Wed 10/14

10:40 pm-2:09 pm

2 stops12h 29m

$722

FlorenceSan Diego

FLO Florence - SAN San Diego

FLOSAN

Florence

Fri 10/9

2:34 pm-7:00 pm

1 stop7h 26m

San Diego

Wed 10/14

10:40 pm-2:09 pm

2 stops12h 29m

$742

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Florence, South Carolina to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to San Diego?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to San Diego from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 70% of people opting to fly with this airline when traveling to San Diego. Keep in mind that there are 7 different airlines that fly to San Diego on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to San Diego according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Florence, South Carolina to San Diego (FLO to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to San Diego

Best Price Found	$634
Fastest flight time	10h 03m
Direct flights	None

The best flight deal from Florence, South Carolina to San Diego found on momondo in the last 72 hours is $634

The fastest flight from Florence, South Carolina to San Diego takes 10h 03m

There are no direct flights from Florence, South Carolina to San Diego. There are no popular flight routes from Florence, South Carolina to San Diego.

Search flight deals

Frequently asked questions about flying from Florence, South Carolina to San Diego

How far is Florence to San Diego by plane?
Florence and San Diego are 2144.5 mi apart from one another. A reasonable flight in good conditions will take 10h 03m.
When did momondo last update prices for flights from Florence Airport to San Diego Airport?
Prices for flights from Florence Airport to San Diego Airport refresh daily.
How many operators does momondo search for flights from Florence Airport to San Diego Airport?
As of September 2026, there is 1 operator available to choose from for flights from Florence Airport to San Diego Airport.
How old do you have to be to fly from Florence Airport to San Diego Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Florence Airport to San Diego Airport.
What documentation or ID do you need to fly to San Diego Airport?
The travel and health documents required for your trip to San Diego Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Diego Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Florence, South Carolina to San Diego?
Based on momondo bookings for flights between Florence, South Carolina and San Diego, the leading airline is American Airlines, making up 100% of the total bookings.

Best airlines flying from Florence, South Carolina to San Diego

Compare and see reviews for airlines that fly from Florence, South Carolina to San Diego with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $518	Free Cancellation	Rating 7.1 12,054 reviews		Search American Airlines flights

Chula Vista

El Cajon

Coronado

National City

La Mesa

Julian

Poway

San Ysidro

Imperial Beach

Santee

Alpine

Lemon Grove

Borrego Springs

Why use momondo?

Why should I use momondo to find a flight deal from Florence to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Florence to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Florence to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Florence with this policy.

How can momondo help me find flights from Florence to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Florence.

I’m not ready to book a flight from Florence to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Florence to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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