What airlines fly to San Diego?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to San Diego from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 75% of people opting to fly with this airline when traveling to San Diego. Keep in mind that there are 8 different airlines that fly to San Diego on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Florence Airport to San Diego Airport?

Prices for flights from Florence Airport to San Diego Airport refresh daily.

How old do you have to be to fly from Florence Airport to San Diego Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Florence Airport to San Diego Airport.

What documentation or ID do you need to fly to San Diego Airport?

The travel and health documents required for your trip to San Diego Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Diego Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$465 Cheap Flights from Florence to San Diego in 2025/26

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0 bags

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Find the cheapest flights from Florence, South Carolina to San Diego

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:15 am - 11:33 am

FLO

SAN

8h 18m1 stop

12:40 pm - 10:43 pm

SAN

FLO

7h 03m1 stop

$465American Airlines

Wed, Jan 14 - Wed, Jan 21

6:15 am - 3:57 pm

FLO

SAN

12h 42m2 stops

7:00 am - 5:09 pm

SAN

FLO

7h 09m1 stop

$470American Airlines

Wed, Jan 14 - Wed, Jan 21

6:15 am - 3:57 pm

FLO

SAN

12h 42m2 stops

10:50 am - 10:43 pm

SAN

FLO

8h 53m2 stops

$475American Airlines

Wed, Jan 14 - Wed, Jan 21

6:15 am - 11:39 am

FLO

SAN

8h 24m1 stop

12:40 pm - 10:43 pm

SAN

FLO

7h 03m1 stop

$581American Airlines

Thu, Jan 8 - Mon, Jan 12

6:15 am - 5:09 pm

FLO

SAN

13h 54m2 stops

7:10 am - 10:43 pm

SAN

FLO

12h 33m2 stops

$591American Airlines

Thu, Jan 8 - Mon, Jan 12

6:15 am - 11:33 am

FLO

SAN

8h 18m1 stop

12:40 pm - 10:43 pm

SAN

FLO

7h 03m1 stop

$592American Airlines

Fri, Jan 9 - Tue, Jan 13

6:15 am - 11:33 am

FLO

SAN

8h 18m1 stop

9:21 am - 10:43 pm

SAN

FLO

10h 22m2 stops

$597American Airlines

Fri, Jan 9 - Tue, Jan 13

6:15 am - 3:03 pm

FLO

SAN

11h 48m2 stops

6:15 am - 10:43 pm

SAN

FLO

13h 28m2 stops

$602American Airlines

Fri, Jan 9 - Tue, Jan 13

6:15 am - 11:33 am

FLO

SAN

8h 18m1 stop

7:00 am - 5:09 pm

SAN

FLO

7h 09m1 stop

$612American Airlines

Wed, Jan 7 - Tue, Jan 13

6:15 am - 11:33 am

FLO

SAN

8h 18m1 stop

12:40 pm - 10:43 pm

SAN

FLO

7h 03m1 stop

$619American Airlines

Fri, Jan 9 - Sun, Jan 11

American Airlines flights from Florence, South Carolina to San Diego

Our best American Airlines deals on Florence, South Carolina to San Diego flight tickets

American Airlines

Jan 14

FLO6:15 amFlorence

8h 18m

1 stop

SAN11:33 amSan Diego

Jan 21

SAN12:40 pmSan Diego

7h 03m

1 stop

FLO10:43 pmFlorence

$465

Find similar

American Airlines

Jan 14

FLO6:15 amFlorence

12h 42m

2 stops

SAN3:57 pmSan Diego

Jan 21

SAN7:00 amSan Diego

7h 09m

1 stop

FLO5:09 pmFlorence

$470

Find similar

American Airlines

Jan 14

FLO6:15 amFlorence

12h 42m

2 stops

SAN3:57 pmSan Diego

Jan 21

SAN10:50 amSan Diego

8h 53m

2 stops

FLO10:43 pmFlorence

$475

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Florence, South Carolina to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Wed 1/14

6:15 am-11:33 am

1 stop8h 18m

San Diego

Wed 1/21

12:40 pm-10:43 pm

1 stop7h 03m

$465

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Wed 1/14

6:15 am-3:57 pm

2 stops12h 42m

San Diego

Wed 1/21

7:00 am-5:09 pm

1 stop7h 09m

$470

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Wed 1/14

6:15 am-3:57 pm

2 stops12h 42m

San Diego

Wed 1/21

10:50 am-10:43 pm

2 stops8h 53m

$475

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Thu 1/8

6:15 am-11:39 am

1 stop8h 24m

San Diego

Mon 1/12

12:40 pm-10:43 pm

1 stop7h 03m

$581

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Thu 1/8

6:15 am-5:09 pm

2 stops13h 54m

San Diego

Mon 1/12

7:10 am-10:43 pm

2 stops12h 33m

$591

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Fri 1/9

6:15 am-11:33 am

1 stop8h 18m

San Diego

Tue 1/13

12:40 pm-10:43 pm

1 stop7h 03m

$592

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Fri 1/9

6:15 am-11:33 am

1 stop8h 18m

San Diego

Tue 1/13

9:21 am-10:43 pm

2 stops10h 22m

$597

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Fri 1/9

6:15 am-3:03 pm

2 stops11h 48m

San Diego

Tue 1/13

6:15 am-10:43 pm

2 stops13h 28m

$602

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Wed 1/7

6:15 am-11:33 am

1 stop8h 18m

San Diego

Tue 1/13

7:00 am-5:09 pm

1 stop7h 09m

$612

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Fri 1/9

6:15 am-11:33 am

1 stop8h 18m

San Diego

Sun 1/11

12:40 pm-10:43 pm

1 stop7h 03m

$619

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Florence, South Carolina to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the morning when flights can be purchased for as low as $519. Flights at noon are often more expensive with an average ticket price of $532.

When to book flights from Florence, South Carolina to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to San Diego according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Florence, South Carolina to San Diego (FLO to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to San Diego

Fastest flight time	8h 24m
Direct flights	None

The fastest flight from Florence, South Carolina to San Diego takes 8h 24m

There are no direct flights from Florence, South Carolina to San Diego. There are no popular flight routes from Florence, South Carolina to San Diego.

Search flight deals

How far is Florence to San Diego by plane?
Florence and San Diego are 2144.5 mi apart from one another. A reasonable flight in good conditions will take 8h 24m.
When did momondo last update prices for flights from Florence Airport to San Diego Airport?
Prices for flights from Florence Airport to San Diego Airport refresh daily.
How old do you have to be to fly from Florence Airport to San Diego Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Florence Airport to San Diego Airport.
What documentation or ID do you need to fly to San Diego Airport?
The travel and health documents required for your trip to San Diego Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Diego Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Coronado

Chula Vista

El Cajon

Julian

National City

Imperial Beach

Poway

La Mesa

Borrego Springs

San Ysidro

Alpine

Lemon Grove

Santee

Why use momondo?

Why should I use momondo to find a flight deal from Florence to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Florence to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Florence to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Florence with this policy.

How can momondo help me find flights from Florence to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Florence.

I’m not ready to book a flight from Florence to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Florence to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.