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Cheap flights from Florence, South Carolina to San Diego from $465

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to San Diego departing on 10/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Florence, South Carolina to San Diego

Cheap round-trip flights

American Airlines Logo
6:14 am - 10:20 amFLO-SAN
7h 06m1 stop
American Airlines Logo
1:16 pm - 11:13 pmSAN-FLO
6h 57m1 stop
$465American Airlines
Find Deal
Sat, Oct 4 - Wed, Oct 8
American Airlines Logo
6:14 am - 3:53 pmFLO-SAN
12h 39m2 stops
American Airlines Logo
10:31 pm - 10:46 amSAN-FLO
9h 15m1 stop
$470American Airlines
Find Deal
Sat, Oct 4 - Wed, Oct 8
American Airlines Logo
6:14 am - 2:30 pmFLO-SAN
11h 16m2 stops
American Airlines Logo
10:02 am - 11:13 pmSAN-FLO
10h 11m2 stops
$475American Airlines
Find Deal
Sat, Oct 4 - Wed, Oct 8
American Airlines Logo
6:14 am - 10:20 amFLO-SAN
7h 06m1 stop
American Airlines Logo
1:16 pm - 11:13 pmSAN-FLO
6h 57m1 stop
$565American Airlines
Find Deal
Sat, Oct 4 - Tue, Oct 7
American Airlines Logo
6:14 am - 10:20 amFLO-SAN
7h 06m1 stop
American Airlines Logo
12:54 pm - 12:03 amSAN-FLO
8h 09m1 stop
$592American Airlines
Find Deal
Sat, Oct 4 - Fri, Oct 10
American Airlines Logo
6:14 am - 10:20 amFLO-SAN
7h 06m1 stop
American Airlines Logo
10:02 am - 2:04 pmSAN-FLO
25h 02m2 stops
$597American Airlines
Find Deal
Sat, Oct 4 - Fri, Oct 10
American Airlines Logo
11:18 am - 8:16 pmFLO-SAN
11h 58m2 stops
American Airlines Logo
8:18 am - 11:13 pmSAN-FLO
11h 55m2 stops
$602American Airlines
Find Deal
Thu, Oct 2 - Wed, Oct 8
American Airlines Logo
5:14 am - 9:27 amFLO-SAN
7h 13m1 stop
American Airlines Logo
12:54 pm - 12:03 amSAN-FLO
8h 09m1 stop
$619American Airlines
Find Deal
Thu, Oct 2 - Mon, Oct 6
American Airlines Logo
11:18 am - 8:16 pmFLO-SAN
11h 58m2 stops
American Airlines Logo
11:46 am - 12:03 amSAN-FLO
9h 17m1 stop
$624American Airlines
Find Deal
Thu, Oct 2 - Mon, Oct 6
American Airlines Logo
11:18 am - 8:16 pmFLO-SAN
11h 58m2 stops
American Airlines Logo
6:15 am - 11:13 pmSAN-FLO
13h 58m2 stops
$629American Airlines
Find Deal
Thu, Oct 2 - Tue, Oct 7

American Airlines flights from Florence, South Carolina to San Diego

Our best American Airlines deals on Florence, South Carolina to San Diego flight tickets
American Airlines
Oct 4
FLO6:14 amFlorence
7h 06m
1 stop
SAN10:20 amSan Diego
Oct 8
SAN1:16 pmSan Diego
6h 57m
1 stop
FLO11:13 pmFlorence
$465
Find similar
American Airlines
Oct 4
FLO6:14 amFlorence
12h 39m
2 stops
SAN3:53 pmSan Diego
Oct 8
SAN10:31 pmSan Diego
9h 15m
1 stop
FLO10:46 amFlorence
$470
Find similar
American Airlines
Oct 4
FLO6:14 amFlorence
11h 16m
2 stops
SAN2:30 pmSan Diego
Oct 8
SAN10:02 amSan Diego
10h 11m
2 stops
FLO11:13 pmFlorence
$475
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 25, 2025.
Use the filters below to find and compare flights from Florence, South Carolina to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Sat 10/4

6:14 am-10:20 am

1 stop7h 06m

San Diego

Wed 10/8

1:16 pm-11:13 pm

1 stop6h 57m

$465

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Sat 10/4

6:14 am-3:53 pm

2 stops12h 39m

San Diego

Wed 10/8

10:31 pm-10:46 am

1 stop9h 15m

$470

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Sat 10/4

6:14 am-2:30 pm

2 stops11h 16m

San Diego

Wed 10/8

10:02 am-11:13 pm

2 stops10h 11m

$475

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Sat 10/4

6:14 am-10:20 am

1 stop7h 06m

San Diego

Tue 10/7

1:16 pm-11:13 pm

1 stop6h 57m

$565

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Sat 10/4

6:14 am-10:20 am

1 stop7h 06m

San Diego

Fri 10/10

12:54 pm-12:03 am

1 stop8h 09m

$592

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Sat 10/4

6:14 am-10:20 am

1 stop7h 06m

San Diego

Fri 10/10

10:02 am-2:04 pm

2 stops25h 02m

$597

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Thu 10/2

11:18 am-8:16 pm

2 stops11h 58m

San Diego

Wed 10/8

8:18 am-11:13 pm

2 stops11h 55m

$602

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Thu 10/2

5:14 am-9:27 am

1 stop7h 13m

San Diego

Mon 10/6

12:54 pm-12:03 am

1 stop8h 09m

$619

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Thu 10/2

11:18 am-8:16 pm

2 stops11h 58m

San Diego

Mon 10/6

11:46 am-12:03 am

1 stop9h 17m

$624

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Thu 10/2

11:18 am-8:16 pm

2 stops11h 58m

San Diego

Tue 10/7

6:15 am-11:13 pm

2 stops13h 58m

$629

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to San Diego from

How to get the cheapest flight ticket from Florence, South Carolina to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is in the morning when flights can be purchased for as low as $519. Flights at noon are often more expensive with an average ticket price of $532.

When to book flights from Florence, South Carolina to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to San Diego (FLO to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to San Diego

Direct flights

None
There are no direct flights from Florence, South Carolina to San Diego. There are no popular flight routes from Florence, South Carolina to San Diego.
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  • How far is Florence to San Diego by plane?

    Florence and San Diego are 2144.5 mi apart from one another. A reasonable flight in good conditions will take 6h 55m.

  • When did momondo last update prices for flights from Florence Airport to San Diego Airport?

    Prices for flights from Florence Airport to San Diego Airport refresh daily.

  • How old do you have to be to fly from Florence Airport to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Florence Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents required for your trip to San Diego Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Diego Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
La Mesa
National City
Imperial Beach
Poway
San Ysidro
Borrego Springs
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Florence to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Florence to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Florence to San Diego with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Diego from Florence with this policy.

How can momondo help me find flights from Florence to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Florence.

I’m not ready to book a flight from Florence to San Diego right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Florence to San Diego flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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