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Cheap flights from Des Moines to McAllen from $159

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to McAllen departing on 11/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to McAllen

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 pm - 11:14 pmDSM-MFE
5h 14m1 stop
American Airlines Logo
11:53 am - 4:49 pmMFE-DSM
4h 56m1 stop
$259American Airlines
Find Deal
Fri, Dec 5 - Fri, Dec 12
American Airlines Logo
5:25 pm - 10:56 pmDSM-MFE
5h 31m1 stop
American Airlines Logo
4:54 pm - 10:48 pmMFE-DSM
5h 54m1 stop
$260American Airlines
Find Deal
Thu, Dec 4 - Thu, Dec 11
American Airlines Logo
5:00 am - 10:42 amDSM-MFE
5h 42m1 stop
American Airlines Logo
9:43 am - 2:56 pmMFE-DSM
5h 13m1 stop
$289American Airlines
Find Deal
Tue, Nov 4 - Sat, Nov 8
United Airlines Logo
1:35 pm - 9:59 pmDSM-MFE
8h 24m2 stops
United Airlines Logo
7:00 am - 2:11 pmMFE-DSM
7h 11m1 stop
$320United Airlines
Find Deal
Wed, Nov 5 - Sun, Nov 9
Delta Logo
2:16 pm - 11:56 pmDSM-MFE
9h 40m2 stops
Delta Logo
5:25 am - 4:16 pmMFE-DSM
10h 51m2 stops
$334Delta
Find Deal
Thu, Dec 11 - Sun, Dec 14
United Airlines Logo
2:52 pm - 8:08 pmDSM-MFE
5h 16m1 stop
United Airlines Logo
7:00 am - 2:11 pmMFE-DSM
7h 11m1 stop
$340United Airlines
Find Deal
Wed, Nov 5 - Sun, Nov 9
Delta Logo
5:45 am - 4:55 pmDSM-MFE
11h 10m2 stops
Delta Logo
1:00 pm - 10:28 pmMFE-DSM
9h 28m2 stops
$420Delta
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Sat, Mar 28 - Wed, Apr 1
Multiple Airlines Logo
8:30 am - 11:24 amDSM-MFE
26h 54m1 stop
Multiple Airlines Logo
8:12 pm - 8:00 pmMFE-DSM
23h 48m2 stops
$524Multiple Airlines
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Sun, Dec 21 - Wed, Dec 24
Multiple Airlines Logo
7:00 am - 8:35 pmDSM-MFE
13h 35m2 stops
Multiple Airlines Logo
12:44 pm - 9:09 pmMFE-DSM
32h 25m3 stops
$540Multiple Airlines
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Thu, Dec 11 - Sun, Dec 14
Allegiant Air Logo
7:54 pm - 9:37 pmDSM-MFE
25h 43m1 stop
Allegiant Air Logo
6:36 pm - 8:41 amMFE-DSM
38h 05m2 stops
$692Allegiant Air
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Mon, Dec 22 - Fri, Jan 2

Delta flights from Des Moines to McAllen

Our best Delta deals on Des Moines to McAllen flight tickets
Delta
Dec 11
DSM2:16 pmDes Moines
9h 40m
2 stops
MFE11:56 pmMcAllen Miller Intl
Dec 14
MFE5:25 amMcAllen Miller Intl
10h 51m
2 stops
DSM4:16 pmDes Moines
$334
Find similar
Delta
Mar 28
DSM5:45 amDes Moines
11h 10m
2 stops
MFE4:55 pmMcAllen Miller Intl
Apr 1
MFE1:00 pmMcAllen Miller Intl
9h 28m
2 stops
DSM10:28 pmDes Moines
$420
Find similar
Delta
Mar 28
DSM5:45 amDes Moines
11h 10m
2 stops
MFE4:55 pmMcAllen Miller Intl
Apr 1
MFE1:00 pmMcAllen Miller Intl
9h 28m
2 stops
DSM10:28 pmDes Moines
$425
Find similar

American Airlines flights from Des Moines to McAllen

Our best American Airlines deals on Des Moines to McAllen flight tickets
American Airlines
Dec 5
DSM6:00 pmDes Moines
5h 14m
1 stop
MFE11:14 pmMcAllen Miller Intl
Dec 12
MFE11:53 amMcAllen Miller Intl
4h 56m
1 stop
DSM4:49 pmDes Moines
$259
Find similar
American Airlines
Dec 4
DSM5:25 pmDes Moines
5h 31m
1 stop
MFE10:56 pmMcAllen Miller Intl
Dec 11
MFE4:54 pmMcAllen Miller Intl
5h 54m
1 stop
DSM10:48 pmDes Moines
$260
Find similar
American Airlines
Nov 4
DSM5:00 amDes Moines
5h 42m
1 stop
MFE10:42 amMcAllen Miller Intl
Nov 8
MFE9:43 amMcAllen Miller Intl
5h 13m
1 stop
DSM2:56 pmDes Moines
$289
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to McAllen that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from Des Moines to McAllen that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Fri 12/5

6:00 pm-11:14 pm

1 stop5h 14m

McAllen Miller Intl

Fri 12/12

11:53 am-4:49 pm

1 stop4h 56m

$259

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Thu 12/4

5:25 pm-10:56 pm

1 stop5h 31m

McAllen Miller Intl

Thu 12/11

4:54 pm-10:48 pm

1 stop5h 54m

$260

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Tue 11/4

5:00 am-10:42 am

1 stop5h 42m

McAllen Miller Intl

Sat 11/8

9:43 am-2:56 pm

1 stop5h 13m

$289

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Wed 11/5

1:35 pm-9:59 pm

2 stops8h 24m

McAllen Miller Intl

Sun 11/9

7:00 am-2:11 pm

1 stop7h 11m

$320

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Thu 12/11

2:16 pm-11:56 pm

2 stops9h 40m

McAllen Miller Intl

Sun 12/14

5:25 am-4:16 pm

2 stops10h 51m

$334

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Wed 11/5

2:52 pm-8:08 pm

1 stop5h 16m

McAllen Miller Intl

Sun 11/9

7:00 am-2:11 pm

1 stop7h 11m

$340

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Sat 3/28

5:45 am-4:55 pm

2 stops11h 10m

McAllen Miller Intl

Wed 4/1

1:00 pm-10:28 pm

2 stops9h 28m

$420

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Sun 12/21

8:30 am-11:24 am

1 stop26h 54m

McAllen Miller Intl

Wed 12/24

8:12 pm-8:00 pm

2 stops23h 48m

$524

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Thu 12/11

7:00 am-8:35 pm

2 stops13h 35m

McAllen Miller Intl

Sun 12/14

12:44 pm-9:09 pm

3 stops32h 25m

$540

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Mon 12/22

7:54 pm-9:37 pm

1 stop25h 43m

McAllen Miller Intl

Fri 1/2

6:36 pm-8:41 am

2 stops38h 05m

$692

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to McAllen from

How to get the cheapest flight ticket from Des Moines to McAllen

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to McAllen?

On average, the least expensive day to fly to McAllen from Des Moines is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $257. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to McAllen for around $397.

What is the cheapest time of day to depart on your flight to McAllen?

Flying to McAllen from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $308 when looking at flights departing in the afternoon. In contrast, the most expensive time of day to depart to McAllen is in the morning when prices are around $363.

When to book flights from Des Moines to McAllen

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to McAllen according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to McAllen (DSM to MFE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to McAllen

Direct flights

None
There are no direct flights from Des Moines to McAllen. There are no popular flight routes from Des Moines to McAllen.
Search flight deals

  • How far is Des Moines to McAllen Miller Intl by plane?

    There are 1093.9 mi between Des Moines and McAllen Miller Intl. 4h 31m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to McAllen Miller Intl Airport?

    Prices for flights from Des Moines Airport to McAllen Miller Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to McAllen Miller Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to McAllen Miller Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to McAllen Miller Intl Airport.

  • What documentation or ID do you need to fly to McAllen Miller Intl Airport?

    The travel and health documents you'll need for your trip to McAllen Miller Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at McAllen Miller Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to McAllen?

Best airlines flying from Des Moines to McAllen

Compare and see reviews for airlines that fly from Des Moines to McAllen with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $247Free CancellationRating
7.2
11,029 reviews
Search American Airlines flights
United AirlinesPriceFrom $258Free CancellationRating
7.4
8,988 reviews
Search United Airlines flights

Traveling to a place near McAllen?

Book flights to McAllen if you plan to visit one of these locations
Weslaco
Pharr
Mission
Edinburg

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to McAllen?

Finding the right flight to McAllen from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to McAllen quick and easy, saving you time and money.

Can I find flights from Des Moines to McAllen with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to McAllen flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to McAllen?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to McAllen.

I’m not ready to book a flight from Des Moines to McAllen right now. Can momondo alert me if prices change?

If you are simply researching potential flights to McAllen, momondo offers a useful price alert feature which will track prices for flights to McAllen from Des Moines and alert you when they change.

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