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Cheap flights from Des Moines to McAllen from $162

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to McAllen departing on 10/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to McAllen (DSM-MFE)

Cheap round-trip flights

American Airlines Logo
5:10 am - 10:08 amDSM-MFE
4h 58m1 stop
American Airlines Logo
6:23 pm - 11:13 pmMFE-DSM
4h 50m1 stop
$309American Airlines
Find Deal
Sat, Sep 13 - Wed, Sep 17
American Airlines Logo
4:27 pm - 12:08 amDSM-MFE
7h 41m2 stops
American Airlines Logo
12:09 pm - 4:14 pmMFE-DSM
4h 05m1 stop
$326American Airlines
Find Deal
Wed, Feb 18 - Wed, Feb 25
American Airlines Logo
4:27 pm - 12:08 amDSM-MFE
7h 41m2 stops
American Airlines Logo
5:00 am - 2:26 pmMFE-DSM
9h 26m2 stops
$331American Airlines
Find Deal
Wed, Feb 18 - Wed, Feb 25
American Airlines Logo
5:10 am - 12:07 pmDSM-MFE
6h 57m1 stop
American Airlines Logo
10:53 am - 3:24 pmMFE-DSM
4h 31m1 stop
$336American Airlines
Find Deal
Sat, Sep 13 - Wed, Sep 17
American Airlines Logo
7:08 am - 5:26 pmDSM-MFE
10h 18m2 stops
American Airlines Logo
6:23 pm - 11:13 pmMFE-DSM
4h 50m1 stop
$341American Airlines
Find Deal
Sat, Sep 13 - Wed, Sep 17
American Airlines Logo
3:30 pm - 10:26 pmDSM-MFE
6h 56m1 stop
American Airlines Logo
10:00 am - 4:14 pmMFE-DSM
6h 14m1 stop
$396American Airlines
Find Deal
Wed, Feb 18 - Wed, Feb 25
Delta Logo
6:00 am - 5:12 pmDSM-MFE
11h 12m2 stops
Delta Logo
5:25 am - 5:13 pmMFE-DSM
11h 48m2 stops
$409Delta
Find Deal
Sat, Sep 13 - Wed, Sep 17
American Airlines Logo
7:31 pm - 11:59 pmDSM-MFE
4h 28m1 stop
American Airlines Logo
10:38 am - 3:03 pmMFE-DSM
4h 25m1 stop
$425American Airlines
Find Deal
Mon, Oct 13 - Mon, Oct 20
United Airlines Logo
6:45 pm - 9:30 pmDSM-MFE
26h 45m3 stops
United Airlines Logo
5:15 am - 2:11 pmMFE-DSM
8h 56m2 stops
$623United Airlines
Find Deal
Wed, Feb 18 - Wed, Feb 25
United Airlines Logo
6:36 pm - 9:57 pmDSM-MFE
27h 21m2 stops
United Airlines Logo
7:25 pm - 2:23 pmMFE-DSM
18h 58m2 stops
$692United Airlines
Find Deal
Mon, Oct 13 - Mon, Oct 20

American Airlines flights from Des Moines to McAllen

Our best American Airlines deals on Des Moines to McAllen flight tickets
American Airlines
Sep 13
DSM5:10 amDes Moines
4h 58m
1 stop
MFE10:08 amMcAllen Miller Intl
Sep 17
MFE6:23 pmMcAllen Miller Intl
4h 50m
1 stop
DSM11:13 pmDes Moines
$309
Find similar
American Airlines
Feb 18
DSM4:27 pmDes Moines
7h 41m
2 stops
MFE12:08 amMcAllen Miller Intl
Feb 25
MFE12:09 pmMcAllen Miller Intl
4h 05m
1 stop
DSM4:14 pmDes Moines
$326
Find similar
American Airlines
Feb 18
DSM4:27 pmDes Moines
7h 41m
2 stops
MFE12:08 amMcAllen Miller Intl
Feb 25
MFE5:00 amMcAllen Miller Intl
9h 26m
2 stops
DSM2:26 pmDes Moines
$331
Find similar

United Airlines flights from Des Moines to McAllen

Our best United Airlines deals on Des Moines to McAllen flight tickets
United Airlines
Feb 18
DSM6:45 pmDes Moines
26h 45m
3 stops
MFE9:30 pmMcAllen Miller Intl
Feb 25
MFE5:15 amMcAllen Miller Intl
8h 56m
2 stops
DSM2:11 pmDes Moines
$623
Find similar
United Airlines
Oct 13
DSM6:36 pmDes Moines
27h 21m
2 stops
MFE9:57 pmMcAllen Miller Intl
Oct 20
MFE7:25 pmMcAllen Miller Intl
18h 58m
2 stops
DSM2:23 pmDes Moines
$692
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to McAllen that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 1, 2025.
Use the filters below to find and compare flights from Des Moines to McAllen that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Sat 9/13

5:10 am-10:08 am

1 stop4h 58m

McAllen Miller Intl

Wed 9/17

6:23 pm-11:13 pm

1 stop4h 50m

$309

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Wed 2/18

4:27 pm-12:08 am

2 stops7h 41m

McAllen Miller Intl

Wed 2/25

12:09 pm-4:14 pm

1 stop4h 05m

$326

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Wed 2/18

4:27 pm-12:08 am

2 stops7h 41m

McAllen Miller Intl

Wed 2/25

5:00 am-2:26 pm

2 stops9h 26m

$331

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Sat 9/13

5:10 am-12:07 pm

1 stop6h 57m

McAllen Miller Intl

Wed 9/17

10:53 am-3:24 pm

1 stop4h 31m

$336

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Sat 9/13

7:08 am-5:26 pm

2 stops10h 18m

McAllen Miller Intl

Wed 9/17

6:23 pm-11:13 pm

1 stop4h 50m

$341

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Wed 2/18

3:30 pm-10:26 pm

1 stop6h 56m

McAllen Miller Intl

Wed 2/25

10:00 am-4:14 pm

1 stop6h 14m

$396

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Sat 9/13

6:00 am-5:12 pm

2 stops11h 12m

McAllen Miller Intl

Wed 9/17

5:25 am-5:13 pm

2 stops11h 48m

$409

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Mon 10/13

7:31 pm-11:59 pm

1 stop4h 28m

McAllen Miller Intl

Mon 10/20

10:38 am-3:03 pm

1 stop4h 25m

$425

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Wed 2/18

6:45 pm-9:30 pm

3 stops26h 45m

McAllen Miller Intl

Wed 2/25

5:15 am-2:11 pm

2 stops8h 56m

$623

Des MoinesMcAllen

DSM - MFE

DSMMFE

Des Moines

Mon 10/13

6:36 pm-9:57 pm

2 stops27h 21m

McAllen Miller Intl

Mon 10/20

7:25 pm-2:23 pm

2 stops18h 58m

$692

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to McAllen from

How to get the cheapest flight ticket from Des Moines to McAllen

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to McAllen?

The month of February is, on average, the cheapest month to fly to McAllen from Des Moines, with most prices found around $331. If you don’t want to visit McAllen in February, then you should wait until November to fly from Des Moines, when ticket prices are also cheap, with an average price of $338.

What is the cheapest day to depart on your flight to McAllen?

On average, the least expensive day to fly to McAllen from Des Moines is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $257. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to McAllen for around $397.

What is the cheapest time of day to depart on your flight to McAllen?

Flying to McAllen from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $308 when looking at flights departing in the afternoon. In contrast, the most expensive time of day to depart to McAllen is in the morning when prices are around $363.

When to book flights from Des Moines to McAllen

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to McAllen according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to McAllen (DSM to MFE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to McAllen

Direct flights

None
There are no direct flights from Des Moines to McAllen. There are no popular flight routes from Des Moines to McAllen.
Search flight deals

  • How far is Des Moines to McAllen Miller Intl by plane?

    There are 1093.9 mi between Des Moines and McAllen Miller Intl. 4h 28m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to McAllen Miller Intl Airport?

    Prices for flights from Des Moines Airport to McAllen Miller Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to McAllen Miller Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to McAllen Miller Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to McAllen Miller Intl Airport.

  • What documentation or ID do you need to fly to McAllen Miller Intl Airport?

    The travel and health documents you'll need for your trip to McAllen Miller Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at McAllen Miller Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to McAllen?

Best airlines flying from Des Moines to McAllen

Compare and see reviews for airlines that fly from Des Moines to McAllen with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $213Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $258Free CancellationRating
7.4
8,936 reviews
Search United Airlines flights

Traveling to a place near McAllen?

Book flights to McAllen if you plan to visit one of these locations
Weslaco
Pharr
Mission
Edinburg

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to McAllen?

Finding the right flight to McAllen from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to McAllen quick and easy, saving you time and money.

Can I find flights from Des Moines to McAllen with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to McAllen flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to McAllen?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to McAllen.

I’m not ready to book a flight from Des Moines to McAllen right now. Can momondo alert me if prices change?

If you are simply researching potential flights to McAllen, momondo offers a useful price alert feature which will track prices for flights to McAllen from Des Moines and alert you when they change.

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