Cheap flights from Des Moines to Los Angeles from $78

The month of January is, on average, the cheapest month to fly to Los Angeles from Des Moines, with most prices found around $313. If you aren’t able to travel during the month of January, then book flights to Los Angeles from Des Moines during September instead. Flights to Los Angeles in September, while not as cheap as those in January, still average around $342.

Our data shows that Wednesday is the least expensive day to fly to Los Angeles. Tickets to fly out on this day can be as low as $352. Be sure to avoid booking your departure on a Tuesday as prices are generally higher than usual. According to our data, the average ticket price to Los Angeles on Tuesday is $521.

Our most recent data shows that the best time of day to fly to Los Angeles is at noon. Flights from Des Moines to Los Angeles during this time can be as low as $369. In the morning is when there is more demand to fly to Los Angeles, so prices are often more expensive at around $668 per ticket.

Fly from Des Moines to Los Angeles for the best Des Moines - Los Angeles flight prices

You are more likely to see cheaper flights to Los Angeles from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Los Angeles for around $375 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Los Angeles from Des Moines for as low as $302 on momondo.

There are 4 cabin classes available to choose from on Des Moines to Los Angeles flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 23% on your flight if you consider stops on a Des Moines to Los Angeles flight.

As of August 2026, prices for Des Moines to Los Angeles flights are approximately 58% more expensive when compared to flights at the same time last year.

Delta and Southwest are the most popular carriers operating from Des Moines to Los Angeles

American Airlines, Allegiant Air and United Airlines are the top three most popular airlines that fly to Los Angeles from Des Moines according to our data. American Airlines is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Los Angeles. Keep in mind that there are 7 different airlines that fly to Los Angeles on a routine basis, so you have a few additional options to choose from.

Denver (DEN) was the most common stop: 90% of momondo users choosing 1-stop flights on this route connected there.

Flights via Denver (DEN) offer the lowest average round-trip price of $305.

Flights connecting via Minneapolis (MSP) have the shortest average one-way travel time: 6h 41m.

Minneapolis (MSP) has the shortest average layover time for this route: 1h 07m.