Cheap flights from Des Moines to Los Angeles from $86

The month of January is, on average, the cheapest month to fly to Los Angeles from Des Moines, with most prices found around $313. If you aren’t able to travel during the month of January, then book flights to Los Angeles from Des Moines during April instead. Flights to Los Angeles in April, while not as cheap as those in January, still average around $332.

Our data shows that Wednesday is the least expensive day to fly to Los Angeles. Tickets to fly out on this day can be as low as $354. Be sure to avoid booking your departure on a Tuesday as prices are generally higher than usual. According to our data, the average ticket price to Los Angeles on Tuesday is $556.

Our most recent data shows that the best time of day to fly to Los Angeles is at noon. Flights from Des Moines to Los Angeles during this time can be as low as $369. In the afternoon is when there is more demand to fly to Los Angeles, so prices are often more expensive at around $416 per ticket.

Fly from Des Moines to Los Angeles Los Angeles for the best Des Moines - Los Angeles Los Angeles flight prices

You are more likely to see cheaper flights to Los Angeles from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Los Angeles for around $360 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Los Angeles from Des Moines for as low as $282 on momondo.

There are 3 cabin classes available to choose from on Des Moines to Los Angeles Los Angeles flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Des Moines to Los Angeles.

As of March 2026, prices for Des Moines to Los Angeles flights are approximately 42% cheaper when compared to flights at the same time last year.

Delta is the most popular carrier operating from Des Moines to Los Angeles Los Angeles

American Airlines, United Airlines and Allegiant Air are the top three most popular airlines that fly to Los Angeles from Des Moines according to our data. American Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Los Angeles. Keep in mind that there are 6 different airlines that fly to Los Angeles on a routine basis, so you have a few additional options to choose from.

Denver (DEN) was the most common stop: 78% of momondo users choosing 1-stop flights on this route connected there.

Flights via Minneapolis (MSP) offer the lowest average round-trip price of $335.

Flights connecting via Minneapolis (MSP) have the shortest average one-way travel time: 6h 35m.

Minneapolis (MSP) has the shortest average layover time for this route: 1h 32m.

As of March 2026, there are 1 flights per day flying from Des Moines to Los Angeles. The most common time of day flights depart is 3:00PM, with 70% of flights taking off in the afternoon.

As of March 2026, there are 9 flights per week flying from Des Moines to Los Angeles. The most common day of the week flights depart is Sat, with 22% of flights taking off on this day.