Cheap flights from Chicago to Los Angeles from $150

In general, December is the cheapest month to fly from Chicago to Santa Ana, California. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $70. If you aren’t able to travel during the month of December, then book flights to Santa Ana, California from Chicago during October instead. Flights to Santa Ana, California in October, while not as cheap as those in December, still average around $84.

The cheapest day to depart from Chicago to Santa Ana, California is on a Saturday. Travelers who choose to depart for Santa Ana, California on a Saturday will often find tickets for as low as $369. The most expensive day to fly to Santa Ana, California is Sunday, with ticket prices averaging around $534.

In the morning is the cheapest time of day to fly from Chicago to Santa Ana, California when you can find flight prices for as low as $397. Flying to Santa Ana, California in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Santa Ana, California is in the evening when prices are around $437.

Fly from Chicago O'Hare Intl to Santa Ana J. Wayne/Orange Cnty for the best Chicago - Santa Ana J. Wayne/Orange Cnty flight prices

You are more likely to see cheaper flights to Santa Ana, California from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Ana, California for around $396 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Ana, California from Chicago for as low as $331 on momondo.

There are 4 cabin classes available to choose from on Chicago to Santa Ana, California flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 10% on your flight if you consider stops on a Chicago to Santa Ana, California flight.

As of June 2026, prices for Chicago to Santa Ana, California flights are approximately 22% more expensive when compared to flights at the same time last year.

United Airlines, Delta, and Alaska Airlines are the most popular carriers operating from Chicago to Santa Ana J. Wayne/Orange Cnty

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Santa Ana, California from Chicago according to our data. American Airlines is the first choice among our users, with 41% of people opting to fly with this airline when traveling to Santa Ana, California. Keep in mind that there are 7 different airlines that fly to Santa Ana, California on a routine basis, so you have a few additional options to choose from.

Denver (DEN) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Salt Lake City (SLC) offer the lowest average round-trip price of $272.

Flights connecting via Denver (DEN) have the shortest average one-way travel time: 6h 07m.

Salt Lake City (SLC) has the shortest average layover time for this route: 1h 04m.

The number of flights available between Chicago and Santa Ana, California is 16 per day as of June 2026. The most frequent departure time is 5:00PM, with 50% of daily flights leaving in the afternoon.

114 flights are operational weekly from Chicago to Santa Ana, California as of June 2026. The most popular departure day for this route is Sun, with 18% of flights per week taking off on this day.