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Cheap flights from Chicago Midway Airport to Knoxville from $67

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago Midway Airport to Knoxville departing on 5/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Chicago Midway Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:47 pm - 5:13 pm
MDW
-
TYS
1h 26mnonstop
Multiple Airlines Logo
6:03 pm - 6:36 pm
TYS
-
MDW
25h 33m
1 stop
$205Multiple Airlines
Thu, May 21 - Thu, May 28
Multiple Airlines Logo
2:20 pm - 10:24 pm
MDW
-
TYS
31h 04m
2 stops
Multiple Airlines Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
$207Multiple Airlines
Thu, May 14 - Sun, May 24
Multiple Airlines Logo
2:47 pm - 5:13 pm
MDW
-
TYS
1h 26mnonstop
Multiple Airlines Logo
9:19 pm - 8:06 pm
TYS
-
MDW
23h 47m
2 stops
$208Multiple Airlines
Thu, May 21 - Thu, May 28
Southwest Logo
9:25 am - 5:10 pm
MDW
-
TYS
6h 45m
1 stop
Southwest Logo
5:50 pm - 10:15 pm
TYS
-
MDW
5h 25m
1 stop
$209Southwest
Wed, Apr 22 - Tue, Apr 28
Allegiant Air Logo
2:46 pm - 5:14 pm
MDW
-
TYS
1h 28mnonstop
Allegiant Air Logo
9:00 am - 8:21 am
TYS
-
MDW
24h 21m
1 stop
$210Allegiant Air
Thu, Jun 4 - Sat, Jun 6
Multiple Airlines Logo
7:41 pm - 11:37 pm
MDW
-
TYS
26h 56m
1 stop
Multiple Airlines Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
$213Multiple Airlines
Sun, May 24 - Thu, May 28
Southwest Logo
5:30 am - 2:20 pm
MDW
-
TYS
7h 50m
1 stop
Southwest Logo
12:50 pm - 8:00 pm
TYS
-
MDW
8h 10m
2 stops
$214Southwest
Wed, Apr 22 - Tue, Apr 28
Multiple Airlines Logo
2:47 pm - 5:13 pm
MDW
-
TYS
1h 26mnonstop
Multiple Airlines Logo
5:05 pm - 7:00 am
TYS
-
MDW
14h 55m
2 stops
$222Multiple Airlines
Thu, May 28 - Tue, Jun 2
Allegiant Air Logo
9:30 pm - 10:18 pm
MDW
-
TYS
23h 48m
1 stop
Allegiant Air Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
$226Allegiant Air
Fri, May 22 - Thu, May 28
Southwest Logo
1:00 pm - 8:50 pm
MDW
-
TYS
6h 50m
1 stop
Southwest Logo
5:50 pm - 10:15 pm
TYS
-
MDW
5h 25m
1 stop
$229Southwest
Tue, Apr 7 - Tue, Apr 14

Southwest flights from Chicago Midway Airport to Knoxville

Our best Southwest deals on Chicago Midway Airport to Knoxville flight tickets
Southwest
Apr 22
MDW9:25 amChicago Midway
6h 45m
1 stop
TYS5:10 pmKnoxville McGhee Tyson
Apr 28
TYS5:50 pmKnoxville McGhee Tyson
5h 25m
1 stop
MDW10:15 pmChicago Midway
$209
Southwest
Apr 22
MDW5:30 amChicago Midway
7h 50m
1 stop
TYS2:20 pmKnoxville McGhee Tyson
Apr 28
TYS12:50 pmKnoxville McGhee Tyson
8h 10m
2 stops
MDW8:00 pmChicago Midway
$214
Southwest
Apr 3
MDW2:35 pmChicago Midway
5h 40m
2 stops
TYS9:15 pmKnoxville McGhee Tyson
Apr 6
TYS6:30 amKnoxville McGhee Tyson
3h 50m
1 stop
MDW9:20 amChicago Midway
$234

Allegiant Air flights from Chicago Midway Airport to Knoxville

Our best Allegiant Air deals on Chicago Midway Airport to Knoxville flight tickets
Allegiant Air
Jun 4
MDW2:46 pmChicago Midway
1h 28m
TYS5:14 pmKnoxville McGhee Tyson
Jun 6
TYS9:00 amKnoxville McGhee Tyson
24h 21m
1 stop
MDW8:21 amChicago Midway
$210
Allegiant Air
May 22
MDW9:30 pmChicago Midway
23h 48m
1 stop
TYS10:18 pmKnoxville McGhee Tyson
May 28
TYS1:22 pmKnoxville McGhee Tyson
1h 35m
MDW1:57 pmChicago Midway
$226
Allegiant Air
Aug 6
MDW2:49 pmChicago Midway
1h 30m
TYS5:19 pmKnoxville McGhee Tyson
Aug 8
TYS5:21 pmKnoxville McGhee Tyson
16h 03m
1 stop
MDW8:24 amChicago Midway
$246

momondo Fare Finder

 
Customize your flight search to find flights from Chicago Midway Airport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Chicago Midway Airport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 5/21

2:47 pm-5:13 pm

Nonstop1h 26m

Knoxville McGhee Tyson

Thu 5/28

6:03 pm-6:36 pm

1 stop25h 33m

$205

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 5/14

2:20 pm-10:24 pm

2 stops31h 04m

Knoxville McGhee Tyson

Sun 5/24

1:22 pm-1:57 pm

Nonstop1h 35m

$207

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 5/21

2:47 pm-5:13 pm

Nonstop1h 26m

Knoxville McGhee Tyson

Thu 5/28

9:19 pm-8:06 pm

2 stops23h 47m

$208
Quickest round-trip

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 4/22

9:25 am-5:10 pm

1 stop6h 45m

Knoxville McGhee Tyson

Tue 4/28

5:50 pm-10:15 pm

1 stop5h 25m

$209

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 6/4

2:46 pm-5:14 pm

Nonstop1h 28m

Knoxville McGhee Tyson

Sat 6/6

9:00 am-8:21 am

1 stop24h 21m

$210

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Sun 5/24

7:41 pm-11:37 pm

1 stop26h 56m

Knoxville McGhee Tyson

Thu 5/28

1:22 pm-1:57 pm

Nonstop1h 35m

$213

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 4/22

5:30 am-2:20 pm

1 stop7h 50m

Knoxville McGhee Tyson

Tue 4/28

12:50 pm-8:00 pm

2 stops8h 10m

$214

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 5/28

2:47 pm-5:13 pm

Nonstop1h 26m

Knoxville McGhee Tyson

Tue 6/2

5:05 pm-7:00 am

2 stops14h 55m

$222

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 5/22

9:30 pm-10:18 pm

1 stop23h 48m

Knoxville McGhee Tyson

Thu 5/28

1:22 pm-1:57 pm

Nonstop1h 35m

$226

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Tue 4/7

1:00 pm-8:50 pm

1 stop6h 50m

Knoxville McGhee Tyson

Tue 4/14

5:50 pm-10:15 pm

1 stop5h 25m

$229

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago Midway Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago Midway Airport to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $259. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago Midway Airport to Knoxville for around $316.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Chicago Midway Airport to Knoxville when you can find flight prices for as low as $267. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $301.

What is the cheapest Chicago Midway to Knoxville McGhee Tyson flight route?

Fly from Chicago Midway to Knoxville McGhee Tyson for the best Chicago Midway - Knoxville McGhee Tyson flight prices

What cabin class options are available on Chicago Midway to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Chicago Midway to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

When to book flights from Chicago Midway Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago Midway Airport to Knoxville (MDW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Knoxville

Best Price Found

$116

Fastest flight time

1h 28m

Direct flights

Mon and Fri

Airports in Knoxville

1 airport
The best flight deal from Chicago Midway Airport to Knoxville found on momondo in the last 72 hours is $116
The fastest flight from Chicago Midway Airport to Knoxville takes 1h 28m
Direct flights go from Chicago Midway Airport to Knoxville on Monday and Friday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Knoxville. From Chicago Midway Airport there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

  • How far is Chicago Midway to Knoxville McGhee Tyson by plane?

    There are 451.6 mi between Chicago Midway and Knoxville McGhee Tyson. Flights usually cover this in 1h 28m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago Midway Airport to Knoxville?

  • What is the most popular airline from Chicago Midway Airport to Knoxville?

Best airlines flying from Chicago Midway Airport to Knoxville

Compare and see reviews for airlines that fly from Chicago Midway Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $80Free CancellationRating
7.3
714 reviews
Search Allegiant Air flights
DeltaPriceFrom $138Free CancellationRating
7.9
8,276 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Chicago.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Chicago on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Chicago to Knoxville?

Once you have performed a search for Chicago to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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