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Cheap flights from Chicago Midway Airport to Knoxville from $47

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago Midway Airport to Knoxville departing on 11/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Chicago Midway Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
12:45 pm - 7:55 pmMDW  Chicago Midway-TYS Knoxville McGhee Tyson
6h 10m1 stop Baltimore/Washington
Southwest Logo
4:55 pm - 7:20 pmTYS  Knoxville McGhee Tyson-MDW Chicago Midway
3h 25m1 stop Nashville Intl
$188Southwest
Wed, Sep 9 - Sat, Sep 12
Southwest Logo
7:40 am - 12:05 pmMDW  Chicago Midway-TYS Knoxville McGhee Tyson
3h 25m1 stop Nashville Intl
Southwest Logo
12:45 pm - 7:15 pmTYS  Knoxville McGhee Tyson-MDW Chicago Midway
7h 30m1 stop Orlando
$188Southwest
Tue, Sep 8 - Tue, Sep 15
Allegiant Air Logo
1:26 pm - 3:51 pmMDW  Chicago Midway-TYS Knoxville McGhee Tyson
1h 25mnonstop
Allegiant Air Logo
12:04 pm - 12:36 pmTYS  Knoxville McGhee Tyson-MDW Chicago Midway
1h 32mnonstop
$191Allegiant Air
Mon, Oct 12 - Mon, Oct 19
Allegiant Air Logo
4:30 pm - 6:55 pmMDW  Chicago Midway-TYS Knoxville McGhee Tyson
1h 25mnonstop
Allegiant Air Logo
1:04 pm - 1:36 pmTYS  Knoxville McGhee Tyson-MDW Chicago Midway
1h 32mnonstop
$193Allegiant Air
Fri, Oct 16 - Fri, Oct 23
Southwest Logo
7:40 am - 12:05 pmMDW  Chicago Midway-TYS Knoxville McGhee Tyson
3h 25m1 stop Nashville Intl
Southwest Logo
8:05 am - 3:25 pmTYS  Knoxville McGhee Tyson-MDW Chicago Midway
8h 20m2 stops Baltimore/Washington Atlanta Hartsfield-Jackson
$193Southwest
Tue, Sep 8 - Tue, Sep 15
Southwest Logo
12:45 pm - 7:55 pmMDW  Chicago Midway-TYS Knoxville McGhee Tyson
6h 10m2 stops Cincinnati Cinci./N. Kentucky Baltimore/Washington
Southwest Logo
4:55 pm - 7:20 pmTYS  Knoxville McGhee Tyson-MDW Chicago Midway
3h 25m1 stop Nashville Intl
$193Southwest
Wed, Sep 9 - Sat, Sep 12
Allegiant Air Logo
9:24 pm - 9:16 pmMDW  Chicago Midway-TYS Knoxville McGhee Tyson
22h 52m1 stop Valparaiso Destin-Ft Walton Beach
Allegiant Air Logo
11:34 am - 12:06 pmTYS  Knoxville McGhee Tyson-MDW Chicago Midway
1h 32mnonstop
$193Allegiant Air
Fri, Oct 2 - Mon, Oct 5
Allegiant Air Logo
12:26 pm - 2:51 pmMDW  Chicago Midway-TYS Knoxville McGhee Tyson
1h 25mnonstop
Allegiant Air Logo
12:04 pm - 12:36 pmTYS  Knoxville McGhee Tyson-MDW Chicago Midway
1h 32mnonstop
$195Allegiant Air
Fri, Oct 9 - Mon, Oct 12
Allegiant Air Logo
2:24 pm - 4:49 pmMDW  Chicago Midway-TYS Knoxville McGhee Tyson
1h 25mnonstop
Allegiant Air Logo
11:34 am - 12:06 pmTYS  Knoxville McGhee Tyson-MDW Chicago Midway
1h 32mnonstop
$196Allegiant Air
Fri, Oct 2 - Mon, Oct 5
Allegiant Air Logo
9:24 pm - 9:16 pmMDW  Chicago Midway-TYS Knoxville McGhee Tyson
22h 52m1 stop Valparaiso Destin-Ft Walton Beach
Allegiant Air Logo
11:34 am - 12:06 pmTYS  Knoxville McGhee Tyson-MDW Chicago Midway
1h 32mnonstop
$198Allegiant Air
Fri, Oct 2 - Mon, Oct 5

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Allegiant Air flights from Chicago Midway Airport to Knoxville

Our best Allegiant Air deals on Chicago Midway Airport to Knoxville flight tickets
Allegiant Air
Aug 13
MDW2:49 pmChicago Midway
1h 30m
TYS5:19 pmKnoxville McGhee Tyson
Aug 16
TYS1:23 pmKnoxville McGhee Tyson
1h 36m
MDW1:59 pmChicago Midway
$186
Allegiant Air
Oct 12
MDW1:26 pmChicago Midway
1h 25m
TYS3:51 pmKnoxville McGhee Tyson
Oct 19
TYS12:04 pmKnoxville McGhee Tyson
1h 32m
MDW12:36 pmChicago Midway
$191
Allegiant Air
Oct 9
MDW12:26 pmChicago Midway
1h 25m
TYS2:51 pmKnoxville McGhee Tyson
Oct 12
TYS12:04 pmKnoxville McGhee Tyson
1h 32m
MDW12:36 pmChicago Midway
$195

Southwest flights from Chicago Midway Airport to Knoxville

Our best Southwest deals on Chicago Midway Airport to Knoxville flight tickets
Southwest
Sep 8
MDW7:40 amChicago Midway
3h 25m
1 stop
TYS12:05 pmKnoxville McGhee Tyson
Sep 15
TYS12:45 pmKnoxville McGhee Tyson
7h 30m
1 stop
MDW7:15 pmChicago Midway
$188
Southwest
Sep 8
MDW7:40 amChicago Midway
3h 25m
1 stop
TYS12:05 pmKnoxville McGhee Tyson
Sep 15
TYS8:05 amKnoxville McGhee Tyson
8h 20m
2 stops
MDW3:25 pmChicago Midway
$193
Southwest
Sep 8
MDW12:45 pmChicago Midway
6h 10m
2 stops
TYS7:55 pmKnoxville McGhee Tyson
Sep 15
TYS8:05 amKnoxville McGhee Tyson
8h 20m
2 stops
MDW3:25 pmChicago Midway
$207

momondo Fare Finder

 
Customize your flight search to find flights from Chicago Midway Airport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Chicago Midway Airport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoKnoxville

MDW Chicago Midway - TYS Knoxville McGhee Tyson

MDWTYS

Chicago Midway

Wed 9/9

12:45 pm-7:55 pm

1 stop6h 10m

Knoxville McGhee Tyson

Sat 9/12

4:55 pm-7:20 pm

1 stop3h 25m

$188

ChicagoKnoxville

MDW Chicago Midway - TYS Knoxville McGhee Tyson

MDWTYS

Chicago Midway

Tue 9/8

7:40 am-12:05 pm

1 stop3h 25m

Knoxville McGhee Tyson

Tue 9/15

12:45 pm-7:15 pm

1 stop7h 30m

$188
Quickest round-trip

ChicagoKnoxville

MDW Chicago Midway - TYS Knoxville McGhee Tyson

MDWTYS

Chicago Midway

Mon 10/12

1:26 pm-3:51 pm

Nonstop1h 25m

Knoxville McGhee Tyson

Mon 10/19

12:04 pm-12:36 pm

Nonstop1h 32m

$191

ChicagoKnoxville

MDW Chicago Midway - TYS Knoxville McGhee Tyson

MDWTYS

Chicago Midway

Fri 10/16

4:30 pm-6:55 pm

Nonstop1h 25m

Knoxville McGhee Tyson

Fri 10/23

1:04 pm-1:36 pm

Nonstop1h 32m

$193

ChicagoKnoxville

MDW Chicago Midway - TYS Knoxville McGhee Tyson

MDWTYS

Chicago Midway

Tue 9/8

7:40 am-12:05 pm

1 stop3h 25m

Knoxville McGhee Tyson

Tue 9/15

8:05 am-3:25 pm

2 stops8h 20m

$193

ChicagoKnoxville

MDW Chicago Midway - TYS Knoxville McGhee Tyson

MDWTYS

Chicago Midway

Wed 9/9

12:45 pm-7:55 pm

2 stops6h 10m

Knoxville McGhee Tyson

Sat 9/12

4:55 pm-7:20 pm

1 stop3h 25m

$193

ChicagoKnoxville

MDW Chicago Midway - TYS Knoxville McGhee Tyson

MDWTYS

Chicago Midway

Fri 10/2

9:24 pm-9:16 pm

1 stop22h 52m

Knoxville McGhee Tyson

Mon 10/5

11:34 am-12:06 pm

Nonstop1h 32m

$193

ChicagoKnoxville

MDW Chicago Midway - TYS Knoxville McGhee Tyson

MDWTYS

Chicago Midway

Fri 10/9

12:26 pm-2:51 pm

Nonstop1h 25m

Knoxville McGhee Tyson

Mon 10/12

12:04 pm-12:36 pm

Nonstop1h 32m

$195

ChicagoKnoxville

MDW Chicago Midway - TYS Knoxville McGhee Tyson

MDWTYS

Chicago Midway

Fri 10/2

2:24 pm-4:49 pm

Nonstop1h 25m

Knoxville McGhee Tyson

Mon 10/5

11:34 am-12:06 pm

Nonstop1h 32m

$196

ChicagoKnoxville

MDW Chicago Midway - TYS Knoxville McGhee Tyson

MDWTYS

Chicago Midway

Fri 10/2

9:24 pm-9:16 pm

1 stop22h 52m

Knoxville McGhee Tyson

Mon 10/5

11:34 am-12:06 pm

Nonstop1h 32m

$198

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago Midway Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of December is, on average, the cheapest month to fly to Knoxville from Chicago Midway Airport, with most prices found around $0. If you aren’t able to travel during the month of December, then book flights to Knoxville from Chicago Midway Airport during January instead. Flights to Knoxville in January, while not as cheap as those in December, still average around $0.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago Midway Airport to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $269. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Chicago Midway Airport to Knoxville for around $374.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Chicago Midway Airport to Knoxville when you can find flight prices for as low as $241. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $343.

What is the cheapest Chicago Midway to Knoxville McGhee Tyson flight route?

Fly from Chicago Midway to Knoxville McGhee Tyson for the best Chicago Midway - Knoxville McGhee Tyson flight prices

What cabin class options are available on Chicago Midway Airport to Knoxville flights?

There is only 1 cabin class available to choose from on Chicago Midway Airport to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

When to book flights from Chicago Midway Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago Midway Airport to Knoxville (MDW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Knoxville

Best Price Found

$103

Fastest flight time

1h 25m

Direct flights

Mon, Tue and Sat

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Chicago Midway Airport in the past 72 hours is $103. The best round-trip flight deal from Chicago Midway Airport to Knoxville found on momondo in the last 72 hours is $97.
The fastest flight from Chicago Midway Airport to Knoxville takes 1h 25m
Direct flights go from Chicago Midway Airport to Knoxville on Monday, Tuesday and Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Knoxville. From Chicago Midway Airport there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

Frequently asked questions about flying from Chicago Midway Airport to Knoxville

  • How far is Chicago Midway to Knoxville McGhee Tyson by plane?

    There are 451.6 mi between Chicago Midway and Knoxville McGhee Tyson. Flights usually cover this in 1h 25m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago Midway Airport to Knoxville?

  • What is the most popular airline from Chicago Midway Airport to Knoxville?

Best airlines flying from Chicago Midway Airport to Knoxville

Compare and see reviews for airlines that fly from Chicago Midway Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $82Free CancellationRating
7.3
679 reviews
Search Allegiant Air flights

  • Allegiant Air Flights From Chicago Midway Airport to Knoxville

    Allegiant Air flight deals from Chicago Midway Airport to Knoxville start from $82 round-trip. Over the 1 Allegiant Air flight for this route in a normal week, average airfare is usually $155 round-trip - but some users have found much cheaper deals with momondo.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Chicago.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Chicago on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Chicago to Knoxville?

Once you have performed a search for Chicago to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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