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Cheap flights from Chicago Midway Airport to Knoxville from $139

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago Midway Airport to Knoxville departing on 1/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Chicago Midway Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:21 pm - 10:10 am
MDW
-
TYS
16h 49m1 stop
Multiple Airlines Logo
12:55 pm - 11:09 pm
TYS
-
MDW
11h 14m1 stop
$203Multiple Airlines
Sun, Jan 11 - Mon, Jan 12
Delta Logo
1:26 pm - 8:47 pm
MDW
-
TYS
6h 21m1 stop
Delta Logo
1:00 pm - 5:55 pm
TYS
-
MDW
5h 55m1 stop
$209Delta
Thu, Jan 29 - Sun, Feb 1
Southwest Logo
3:35 pm - 9:10 pm
MDW
-
TYS
4h 35m1 stop
Southwest Logo
2:25 pm - 9:55 pm
TYS
-
MDW
8h 30m2 stops
$214Southwest
Wed, Mar 25 - Tue, Mar 31
Southwest Logo
1:20 pm - 9:10 pm
MDW
-
TYS
6h 50m2 stops
Southwest Logo
2:25 pm - 9:55 pm
TYS
-
MDW
8h 30m2 stops
$219Southwest
Wed, Mar 25 - Tue, Mar 31
Delta Logo
5:31 pm - 11:45 pm
MDW
-
TYS
5h 14m1 stop
Delta Logo
7:27 am - 12:48 pm
TYS
-
MDW
6h 21m1 stop
$224Delta
Mon, Jan 5 - Sat, Jan 10
Delta Logo
5:31 pm - 11:45 pm
MDW
-
TYS
5h 14m1 stop
Delta Logo
7:27 am - 12:48 pm
TYS
-
MDW
6h 21m1 stop
$234Delta
Mon, Jan 5 - Sat, Jan 10
Multiple Airlines Logo
7:30 am - 10:11 pm
MDW
-
TYS
13h 41m1 stop
Multiple Airlines Logo
5:53 pm - 10:29 pm
TYS
-
MDW
29h 36m2 stops
$242Multiple Airlines
Thu, Feb 26 - Sun, Mar 1
Multiple Airlines Logo
7:30 am - 10:11 pm
MDW
-
TYS
13h 41m1 stop
Multiple Airlines Logo
9:00 am - 8:32 pm
TYS
-
MDW
12h 32m1 stop
$252Multiple Airlines
Thu, Feb 26 - Mon, Mar 2
Southwest Logo
9:30 am - 6:10 pm
MDW
-
TYS
7h 40m1 stop
Southwest Logo
5:45 pm - 10:15 pm
TYS
-
MDW
5h 30m1 stop
$253Southwest
Mon, May 18 - Wed, May 20
Multiple Airlines Logo
7:30 am - 10:11 pm
MDW
-
TYS
13h 41m1 stop
Multiple Airlines Logo
9:00 am - 7:47 pm
TYS
-
MDW
11h 47m2 stops
$256Multiple Airlines
Thu, Feb 26 - Mon, Mar 2

Delta flights from Chicago Midway Airport to Knoxville

Our best Delta deals on Chicago Midway Airport to Knoxville flight tickets
Delta
Feb 23
MDW1:28 pmChicago Midway
6h 17m
1 stop
TYS8:45 pmKnoxville McGhee Tyson
Mar 4
TYS7:30 amKnoxville McGhee Tyson
6h 16m
1 stop
MDW12:46 pmChicago Midway
$209
Find similar
Delta
Jan 5
MDW5:31 pmChicago Midway
5h 14m
1 stop
TYS11:45 pmKnoxville McGhee Tyson
Jan 10
TYS7:27 amKnoxville McGhee Tyson
6h 21m
1 stop
MDW12:48 pmChicago Midway
$224
Find similar
Delta
Jan 26
MDW6:14 pmChicago Midway
4h 31m
1 stop
TYS11:45 pmKnoxville McGhee Tyson
Feb 1
TYS1:00 pmKnoxville McGhee Tyson
5h 55m
1 stop
MDW5:55 pmChicago Midway
$234
Find similar

Southwest flights from Chicago Midway Airport to Knoxville

Our best Southwest deals on Chicago Midway Airport to Knoxville flight tickets
Southwest
Mar 25
MDW3:35 pmChicago Midway
4h 35m
1 stop
TYS9:10 pmKnoxville McGhee Tyson
Mar 31
TYS2:25 pmKnoxville McGhee Tyson
8h 30m
2 stops
MDW9:55 pmChicago Midway
$214
Find similar
Southwest
Mar 25
MDW1:20 pmChicago Midway
6h 50m
2 stops
TYS9:10 pmKnoxville McGhee Tyson
Mar 31
TYS2:25 pmKnoxville McGhee Tyson
8h 30m
2 stops
MDW9:55 pmChicago Midway
$219
Find similar
Southwest
May 15
MDW9:30 amChicago Midway
7h 40m
1 stop
TYS6:10 pmKnoxville McGhee Tyson
May 20
TYS5:45 pmKnoxville McGhee Tyson
5h 30m
1 stop
MDW10:15 pmChicago Midway
$263
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago Midway Airport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Chicago Midway Airport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Sun 1/11

4:21 pm-10:10 am

1 stop16h 49m

Knoxville McGhee Tyson

Mon 1/12

12:55 pm-11:09 pm

1 stop11h 14m

$203

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 1/29

1:26 pm-8:47 pm

1 stop6h 21m

Knoxville McGhee Tyson

Sun 2/1

1:00 pm-5:55 pm

1 stop5h 55m

$209

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 3/25

3:35 pm-9:10 pm

1 stop4h 35m

Knoxville McGhee Tyson

Tue 3/31

2:25 pm-9:55 pm

2 stops8h 30m

$214

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 3/25

1:20 pm-9:10 pm

2 stops6h 50m

Knoxville McGhee Tyson

Tue 3/31

2:25 pm-9:55 pm

2 stops8h 30m

$219

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Mon 1/5

5:31 pm-11:45 pm

1 stop5h 14m

Knoxville McGhee Tyson

Sat 1/10

7:27 am-12:48 pm

1 stop6h 21m

$224

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Mon 1/5

5:31 pm-11:45 pm

1 stop5h 14m

Knoxville McGhee Tyson

Sat 1/10

7:27 am-12:48 pm

1 stop6h 21m

$234

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 2/26

7:30 am-10:11 pm

1 stop13h 41m

Knoxville McGhee Tyson

Sun 3/1

5:53 pm-10:29 pm

2 stops29h 36m

$242

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 2/26

7:30 am-10:11 pm

1 stop13h 41m

Knoxville McGhee Tyson

Mon 3/2

9:00 am-8:32 pm

1 stop12h 32m

$252

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Mon 5/18

9:30 am-6:10 pm

1 stop7h 40m

Knoxville McGhee Tyson

Wed 5/20

5:45 pm-10:15 pm

1 stop5h 30m

$253

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 2/26

7:30 am-10:11 pm

1 stop13h 41m

Knoxville McGhee Tyson

Mon 3/2

9:00 am-7:47 pm

2 stops11h 47m

$256

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago Midway Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago Midway Airport to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $262. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago Midway Airport to Knoxville for around $318.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Chicago Midway Airport to Knoxville when you can find flight prices for as low as $263. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $292.

What is the cheapest Chicago Midway to Knoxville McGhee Tyson flight route?

Fly from Chicago Midway to Knoxville McGhee Tyson for the best Chicago Midway - Knoxville McGhee Tyson flight prices

What cabin class options are available on Chicago Midway to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Chicago Midway to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

When to book flights from Chicago Midway Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago Midway Airport to Knoxville (MDW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Knoxville

Best Price Found

$84

Fastest flight time

3h 31m

Direct flights

None
The best one-way flight to Knoxville from Chicago Midway Airport in the past 72 hours is $84. The best round-trip flight deal from Chicago Midway Airport to Knoxville found on momondo in the last 72 hours is $138.
The fastest flight from Chicago Midway Airport to Knoxville takes 3h 31m
There are no direct flights from Chicago Midway Airport to Knoxville. There are no popular flight routes from Chicago Midway Airport to Knoxville.
Search flight deals

  • How far is Chicago Midway to Knoxville McGhee Tyson by plane?

    There are 451.6 mi between Chicago Midway and Knoxville McGhee Tyson. Flights usually cover this in 3h 31m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago Midway Airport to Knoxville?

  • What is the most popular airline from Chicago Midway Airport to Knoxville?

Best airlines flying from Chicago Midway Airport to Knoxville

Compare and see reviews for airlines that fly from Chicago Midway Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $82Free CancellationRating
7.2
700 reviews
Search Allegiant Air flights
DeltaPriceFrom $208Free CancellationRating
7.9
8,005 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Chicago.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Chicago on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Chicago to Knoxville?

Once you have performed a search for Chicago to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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