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Cheap flights from Chicago Midway Airport to Knoxville from $52

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago Midway Airport to Knoxville departing on 5/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Chicago Midway Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:49 pm - 5:19 pm
MDW
-
TYS
1h 30mnonstop
Multiple Airlines Logo
6:29 pm - 11:12 am
TYS
-
MDW
17h 43m
2 stops
$213Multiple Airlines
Thu, Aug 13 - Mon, Aug 17
Multiple Airlines Logo
5:30 am - 5:30 pm
MDW
-
TYS
11h 00m
1 stop
Multiple Airlines Logo
1:15 pm - 4:00 pm
TYS
-
MDW
27h 45m
1 stop
$217Multiple Airlines
Mon, Apr 13 - Fri, Apr 17
Multiple Airlines Logo
6:00 am - 11:39 pm
MDW
-
TYS
16h 39m
2 stops
Multiple Airlines Logo
1:22 pm - 1:56 pm
TYS
-
MDW
1h 34mnonstop
$218Multiple Airlines
Mon, Jun 8 - Thu, Jun 11
Allegiant Air Logo
9:16 am - 7:55 pm
MDW
-
TYS
9h 39m
1 stop
Allegiant Air Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
$233Allegiant Air
Thu, May 14 - Thu, May 21
Allegiant Air Logo
2:46 pm - 5:14 pm
MDW
-
TYS
1h 28mnonstop
Allegiant Air Logo
6:04 pm - 7:30 pm
TYS
-
MDW
26h 26m
2 stops
$237Allegiant Air
Thu, Jun 11 - Sun, Jun 14
Allegiant Air Logo
2:46 pm - 5:14 pm
MDW
-
TYS
1h 28mnonstop
Allegiant Air Logo
6:04 pm - 7:30 pm
TYS
-
MDW
26h 26m
2 stops
$241Allegiant Air
Thu, Jun 11 - Sun, Jun 14
Multiple Airlines Logo
9:14 am - 5:30 pm
MDW
-
TYS
7h 16m
1 stop
Multiple Airlines Logo
7:00 am - 6:22 pm
TYS
-
MDW
12h 22m
1 stop
$249Multiple Airlines
Mon, Apr 20 - Thu, Apr 23
Allegiant Air Logo
9:23 pm - 9:34 pm
MDW
-
TYS
23h 11m
1 stop
Allegiant Air Logo
1:22 pm - 1:56 pm
TYS
-
MDW
1h 34mnonstop
$250Allegiant Air
Fri, Jun 19 - Sun, Jun 21
Southwest Logo
10:05 am - 7:40 pm
MDW
-
TYS
8h 35m
2 stops
Southwest Logo
5:50 pm - 10:15 pm
TYS
-
MDW
5h 25m
1 stop
$254Southwest
Tue, Apr 28 - Tue, May 5
Multiple Airlines Logo
3:07 pm - 11:37 pm
MDW
-
TYS
31h 30m
2 stops
Multiple Airlines Logo
1:22 pm - 1:57 pm
TYS
-
MDW
1h 35mnonstop
$255Multiple Airlines
Thu, May 21 - Thu, May 28

Delta flights from Chicago Midway Airport to Knoxville

Our best Delta deals on Chicago Midway Airport to Knoxville flight tickets
Delta
Aug 21
MDW10:35 amChicago Midway
3h 32m
1 stop
TYS3:07 pmKnoxville McGhee Tyson
Aug 27
TYS7:30 amKnoxville McGhee Tyson
6h 00m
1 stop
MDW12:30 pmChicago Midway
$269
Delta
May 10
MDW9:22 amChicago Midway
3h 58m
1 stop
TYS2:20 pmKnoxville McGhee Tyson
May 13
TYS3:30 pmKnoxville McGhee Tyson
6h 39m
1 stop
MDW9:09 pmChicago Midway
$291
Delta
Jul 17
MDW12:41 pmChicago Midway
6h 12m
1 stop
TYS7:53 pmKnoxville McGhee Tyson
Jul 21
TYS6:05 pmKnoxville McGhee Tyson
5h 10m
1 stop
MDW10:15 pmChicago Midway
$294

Allegiant Air flights from Chicago Midway Airport to Knoxville

Our best Allegiant Air deals on Chicago Midway Airport to Knoxville flight tickets
Allegiant Air
May 14
MDW9:16 amChicago Midway
9h 39m
1 stop
TYS7:55 pmKnoxville McGhee Tyson
May 21
TYS1:22 pmKnoxville McGhee Tyson
1h 35m
MDW1:57 pmChicago Midway
$233
Allegiant Air
Jun 11
MDW2:46 pmChicago Midway
1h 28m
TYS5:14 pmKnoxville McGhee Tyson
Jun 14
TYS6:04 pmKnoxville McGhee Tyson
26h 26m
2 stops
MDW7:30 pmChicago Midway
$237
Allegiant Air
Jun 11
MDW2:46 pmChicago Midway
1h 28m
TYS5:14 pmKnoxville McGhee Tyson
Jun 14
TYS6:04 pmKnoxville McGhee Tyson
26h 26m
2 stops
MDW7:30 pmChicago Midway
$241

momondo Fare Finder

 
Customize your flight search to find flights from Chicago Midway Airport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 2, 2026.
Use the filters below to find and compare flights from Chicago Midway Airport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 8/13

2:49 pm-5:19 pm

Nonstop1h 30m

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-11:12 am

2 stops17h 43m

$213

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Mon 4/13

5:30 am-5:30 pm

1 stop11h 00m

Knoxville McGhee Tyson

Fri 4/17

1:15 pm-4:00 pm

1 stop27h 45m

$217

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Mon 6/8

6:00 am-11:39 pm

2 stops16h 39m

Knoxville McGhee Tyson

Thu 6/11

1:22 pm-1:56 pm

Nonstop1h 34m

$218
Quickest round-trip

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 5/14

9:16 am-7:55 pm

1 stop9h 39m

Knoxville McGhee Tyson

Thu 5/21

1:22 pm-1:57 pm

Nonstop1h 35m

$233

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 6/11

2:46 pm-5:14 pm

Nonstop1h 28m

Knoxville McGhee Tyson

Sun 6/14

6:04 pm-7:30 pm

2 stops26h 26m

$237

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 6/11

2:46 pm-5:14 pm

Nonstop1h 28m

Knoxville McGhee Tyson

Sun 6/14

6:04 pm-7:30 pm

2 stops26h 26m

$241

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Mon 4/20

9:14 am-5:30 pm

1 stop7h 16m

Knoxville McGhee Tyson

Thu 4/23

7:00 am-6:22 pm

1 stop12h 22m

$249

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 6/19

9:23 pm-9:34 pm

1 stop23h 11m

Knoxville McGhee Tyson

Sun 6/21

1:22 pm-1:56 pm

Nonstop1h 34m

$250

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Tue 4/28

10:05 am-7:40 pm

2 stops8h 35m

Knoxville McGhee Tyson

Tue 5/5

5:50 pm-10:15 pm

1 stop5h 25m

$254

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 5/21

3:07 pm-11:37 pm

2 stops31h 30m

Knoxville McGhee Tyson

Thu 5/28

1:22 pm-1:57 pm

Nonstop1h 35m

$255

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago Midway Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago Midway Airport and Knoxville?

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago Midway Airport to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $265. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago Midway Airport to Knoxville for around $317.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Chicago Midway Airport to Knoxville when you can find flight prices for as low as $262. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $313.

What is the cheapest Chicago Midway to Knoxville McGhee Tyson flight route?

Fly from Chicago Midway to Knoxville McGhee Tyson for the best Chicago Midway - Knoxville McGhee Tyson flight prices

What cabin class options are available on Chicago Midway to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Chicago Midway to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

When to book flights from Chicago Midway Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago Midway Airport to Knoxville (MDW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Knoxville

Best Price Found

$106

Fastest flight time

1h 25m

Direct flights

Mon and Fri

Airports in Knoxville

1 airport
The best flight deal from Chicago Midway Airport to Knoxville found on momondo in the last 72 hours is $106
The fastest flight from Chicago Midway Airport to Knoxville takes 1h 25m
Direct flights go from Chicago Midway Airport to Knoxville on Monday and Friday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Knoxville. From Chicago Midway Airport there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

Frequently asked questions about flying from Chicago Midway Airport to Knoxville

  • How far is Chicago Midway to Knoxville McGhee Tyson by plane?

    There are 451.6 mi between Chicago Midway and Knoxville McGhee Tyson. Flights usually cover this in 1h 25m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago Midway Airport to Knoxville?

  • What is the most popular airline from Chicago Midway Airport to Knoxville?

Best airlines flying from Chicago Midway Airport to Knoxville

Compare and see reviews for airlines that fly from Chicago Midway Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $61Free CancellationRating
7.3
709 reviews
Search Allegiant Air flights
DeltaPriceFrom $138Free CancellationRating
7.9
8,370 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Chicago.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Chicago on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Chicago to Knoxville?

Once you have performed a search for Chicago to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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