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Cheap flights from Chicago Midway Airport to Knoxville from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago Midway Airport to Knoxville departing on 3/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Chicago Midway Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:07 pm - 11:57 pm
MDW
-
TYS
4h 50m
1 stop
Delta Logo
7:40 am - 12:29 pm
TYS
-
MDW
5h 49m
1 stop
$209Delta
Tue, Mar 24 - Sat, Mar 28
Southwest Logo
7:45 am - 5:40 pm
MDW
-
TYS
8h 55m
2 stops
Southwest Logo
7:25 pm - 12:05 am
TYS
-
MDW
5h 40m
1 stop
$214Southwest
Wed, Mar 25 - Mon, Mar 30
Southwest Logo
1:20 pm - 9:10 pm
MDW
-
TYS
6h 50m
2 stops
Southwest Logo
6:35 am - 4:00 pm
TYS
-
MDW
10h 25m
2 stops
$219Southwest
Tue, Mar 24 - Tue, Mar 31
Delta Logo
10:45 am - 4:06 pm
MDW
-
TYS
4h 21m
1 stop
Delta Logo
7:40 am - 12:29 pm
TYS
-
MDW
5h 49m
1 stop
$224Delta
Wed, Mar 11 - Sat, Mar 21
Delta Logo
1:29 pm - 8:55 pm
MDW
-
TYS
6h 26m
1 stop
Delta Logo
5:10 pm - 10:31 pm
TYS
-
MDW
6h 21m
1 stop
$239Delta
Sat, Mar 7 - Tue, Mar 10
Southwest Logo
4:05 pm - 9:15 pm
MDW
-
TYS
4h 10m
1 stop
Southwest Logo
2:55 pm - 9:45 pm
TYS
-
MDW
7h 50m
1 stop
$244Southwest
Fri, Apr 3 - Tue, Apr 7
Southwest Logo
4:05 pm - 9:15 pm
MDW
-
TYS
4h 10m
1 stop
Southwest Logo
2:55 pm - 10:15 pm
TYS
-
MDW
8h 20m
2 stops
$249Southwest
Fri, Apr 3 - Tue, Apr 7
Southwest Logo
10:00 am - 5:40 pm
MDW
-
TYS
6h 40m
1 stop
Southwest Logo
6:20 pm - 10:50 pm
TYS
-
MDW
5h 30m
1 stop
$253Southwest
Wed, Mar 18 - Wed, Mar 25
Southwest Logo
7:45 am - 5:40 pm
MDW
-
TYS
8h 55m
2 stops
Southwest Logo
7:50 am - 1:50 pm
TYS
-
MDW
7h 00m
2 stops
$254Southwest
Wed, Mar 25 - Wed, Apr 1
Southwest Logo
3:35 pm - 9:10 pm
MDW
-
TYS
4h 35m
1 stop
Southwest Logo
7:50 am - 1:50 pm
TYS
-
MDW
7h 00m
2 stops
$258Southwest
Wed, Mar 18 - Wed, Mar 25

Southwest flights from Chicago Midway Airport to Knoxville

Our best Southwest deals on Chicago Midway Airport to Knoxville flight tickets
Southwest
Mar 25
MDW7:45 amChicago Midway
8h 55m
2 stops
TYS5:40 pmKnoxville McGhee Tyson
Mar 30
TYS7:25 pmKnoxville McGhee Tyson
5h 40m
1 stop
MDW12:05 amChicago Midway
$214
Southwest
Mar 24
MDW1:20 pmChicago Midway
6h 50m
2 stops
TYS9:10 pmKnoxville McGhee Tyson
Mar 31
TYS6:35 amKnoxville McGhee Tyson
10h 25m
2 stops
MDW4:00 pmChicago Midway
$219
Southwest
Apr 3
MDW4:05 pmChicago Midway
4h 10m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
Apr 7
TYS2:55 pmKnoxville McGhee Tyson
7h 50m
1 stop
MDW9:45 pmChicago Midway
$244

Delta flights from Chicago Midway Airport to Knoxville

Our best Delta deals on Chicago Midway Airport to Knoxville flight tickets
Delta
Mar 24
MDW6:07 pmChicago Midway
4h 50m
1 stop
TYS11:57 pmKnoxville McGhee Tyson
Mar 28
TYS7:40 amKnoxville McGhee Tyson
5h 49m
1 stop
MDW12:29 pmChicago Midway
$209
Delta
Mar 11
MDW10:45 amChicago Midway
4h 21m
1 stop
TYS4:06 pmKnoxville McGhee Tyson
Mar 21
TYS7:40 amKnoxville McGhee Tyson
5h 49m
1 stop
MDW12:29 pmChicago Midway
$224
Delta
Mar 7
MDW1:29 pmChicago Midway
6h 26m
1 stop
TYS8:55 pmKnoxville McGhee Tyson
Mar 10
TYS5:10 pmKnoxville McGhee Tyson
6h 21m
1 stop
MDW10:31 pmChicago Midway
$239

momondo Fare Finder

 
Customize your flight search to find flights from Chicago Midway Airport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from Chicago Midway Airport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Tue 3/24

6:07 pm-11:57 pm

1 stop4h 50m

Knoxville McGhee Tyson

Sat 3/28

7:40 am-12:29 pm

1 stop5h 49m

$209

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 3/25

7:45 am-5:40 pm

2 stops8h 55m

Knoxville McGhee Tyson

Mon 3/30

7:25 pm-12:05 am

1 stop5h 40m

$214

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Tue 3/24

1:20 pm-9:10 pm

2 stops6h 50m

Knoxville McGhee Tyson

Tue 3/31

6:35 am-4:00 pm

2 stops10h 25m

$219

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 3/11

10:45 am-4:06 pm

1 stop4h 21m

Knoxville McGhee Tyson

Sat 3/21

7:40 am-12:29 pm

1 stop5h 49m

$224

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Sat 3/7

1:29 pm-8:55 pm

1 stop6h 26m

Knoxville McGhee Tyson

Tue 3/10

5:10 pm-10:31 pm

1 stop6h 21m

$239

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 4/3

4:05 pm-9:15 pm

1 stop4h 10m

Knoxville McGhee Tyson

Tue 4/7

2:55 pm-9:45 pm

1 stop7h 50m

$244

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 4/3

4:05 pm-9:15 pm

1 stop4h 10m

Knoxville McGhee Tyson

Tue 4/7

2:55 pm-10:15 pm

2 stops8h 20m

$249

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 3/18

10:00 am-5:40 pm

1 stop6h 40m

Knoxville McGhee Tyson

Wed 3/25

6:20 pm-10:50 pm

1 stop5h 30m

$253

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 3/25

7:45 am-5:40 pm

2 stops8h 55m

Knoxville McGhee Tyson

Wed 4/1

7:50 am-1:50 pm

2 stops7h 00m

$254

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 3/18

3:35 pm-9:10 pm

1 stop4h 35m

Knoxville McGhee Tyson

Wed 3/25

7:50 am-1:50 pm

2 stops7h 00m

$258

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago Midway Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago Midway Airport to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $259. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago Midway Airport to Knoxville for around $316.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Chicago Midway Airport to Knoxville when you can find flight prices for as low as $266. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $300.

What is the cheapest Chicago Midway to Knoxville McGhee Tyson flight route?

Fly from Chicago Midway to Knoxville McGhee Tyson for the best Chicago Midway - Knoxville McGhee Tyson flight prices

What cabin class options are available on Chicago Midway to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Chicago Midway to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

When to book flights from Chicago Midway Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago Midway Airport to Knoxville (MDW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Knoxville

Fastest flight time

1h 26m

Direct flights

Fri

Airports in Knoxville

1 airport
The fastest flight from Chicago Midway Airport to Knoxville takes 1h 26m
Direct flights go from Chicago Midway Airport to Knoxville on Friday. There are no airlines offering direct flights.
There is 1 airport in Knoxville. From Chicago Midway Airport there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

  • How far is Chicago Midway to Knoxville McGhee Tyson by plane?

    There are 451.6 mi between Chicago Midway and Knoxville McGhee Tyson. Flights usually cover this in 1h 26m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago Midway Airport to Knoxville?

  • What is the most popular airline from Chicago Midway Airport to Knoxville?

Best airlines flying from Chicago Midway Airport to Knoxville

Compare and see reviews for airlines that fly from Chicago Midway Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $80Free CancellationRating
7.2
711 reviews
Search Allegiant Air flights
DeltaPriceFrom $138Free CancellationRating
7.9
8,234 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Chicago.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Chicago on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Chicago to Knoxville?

Once you have performed a search for Chicago to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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