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Cheap flights from Chicago Midway Airport to Knoxville from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago Midway Airport to Knoxville departing on 3/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Chicago Midway Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
3:35 pm - 9:10 pm
MDW
-
TYS
4h 35m
1 stop
Southwest Logo
12:30 pm - 7:20 pm
TYS
-
MDW
7h 50m
1 stop
$209Southwest
Wed, Mar 11 - Tue, Mar 17
Southwest Logo
1:20 pm - 9:10 pm
MDW
-
TYS
6h 50m
2 stops
Southwest Logo
6:20 pm - 10:50 pm
TYS
-
MDW
5h 30m
1 stop
$214Southwest
Wed, Mar 11 - Tue, Mar 17
Delta Logo
10:35 am - 3:06 pm
MDW
-
TYS
3h 31m
1 stop
Delta Logo
7:30 am - 12:30 pm
TYS
-
MDW
6h 00m
1 stop
$219Delta
Wed, Aug 5 - Sat, Aug 8
Southwest Logo
10:15 am - 10:10 pm
MDW
-
TYS
10h 55m
2 stops
Southwest Logo
7:25 pm - 12:05 am
TYS
-
MDW
5h 40m
1 stop
$220Southwest
Sat, Mar 7 - Mon, Mar 9
Multiple Airlines Logo
8:00 am - 9:50 pm
MDW
-
TYS
12h 50m
1 stop
Multiple Airlines Logo
4:56 pm - 10:19 pm
TYS
-
MDW
30h 23m
2 stops
$221Multiple Airlines
Sun, Mar 8 - Tue, Mar 17
Delta Logo
9:35 am - 4:43 pm
MDW
-
TYS
6h 08m
1 stop
Delta Logo
7:00 pm - 10:28 pm
TYS
-
MDW
4h 28m
1 stop
$244Delta
Mon, Mar 23 - Sun, Apr 19
Delta Logo
6:00 am - 11:08 am
MDW
-
TYS
4h 08m
1 stop
Delta Logo
7:38 am - 12:46 pm
TYS
-
MDW
6h 08m
1 stop
$249Delta
Wed, Feb 25 - Sat, Feb 28
Multiple Airlines Logo
8:00 am - 9:50 pm
MDW
-
TYS
12h 50m
1 stop
Multiple Airlines Logo
9:43 pm - 2:21 pm
TYS
-
MDW
17h 38m
1 stop
$250Multiple Airlines
Sun, Mar 8 - Sun, Mar 22
Multiple Airlines Logo
2:41 pm - 10:26 pm
MDW
-
TYS
54h 45m
2 stops
Multiple Airlines Logo
2:06 pm - 11:51 pm
TYS
-
MDW
10h 45m
1 stop
$251Multiple Airlines
Fri, Mar 6 - Fri, Mar 13
Multiple Airlines Logo
8:00 am - 9:50 pm
MDW
-
TYS
12h 50m
1 stop
Multiple Airlines Logo
8:30 am - 6:13 pm
TYS
-
MDW
10h 43m
1 stop
$252Multiple Airlines
Sun, Mar 8 - Wed, Mar 25

Southwest flights from Chicago Midway Airport to Knoxville

Our best Southwest deals on Chicago Midway Airport to Knoxville flight tickets
Southwest
Mar 11
MDW3:35 pmChicago Midway
4h 35m
1 stop
TYS9:10 pmKnoxville McGhee Tyson
Mar 17
TYS12:30 pmKnoxville McGhee Tyson
7h 50m
1 stop
MDW7:20 pmChicago Midway
$209
Southwest
Mar 11
MDW1:20 pmChicago Midway
6h 50m
2 stops
TYS9:10 pmKnoxville McGhee Tyson
Mar 17
TYS6:20 pmKnoxville McGhee Tyson
5h 30m
1 stop
MDW10:50 pmChicago Midway
$214
Southwest
Mar 7
MDW10:15 amChicago Midway
10h 55m
2 stops
TYS10:10 pmKnoxville McGhee Tyson
Mar 9
TYS7:25 pmKnoxville McGhee Tyson
5h 40m
1 stop
MDW12:05 amChicago Midway
$220

Delta flights from Chicago Midway Airport to Knoxville

Our best Delta deals on Chicago Midway Airport to Knoxville flight tickets
Delta
Aug 5
MDW10:35 amChicago Midway
3h 31m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
Aug 8
TYS7:30 amKnoxville McGhee Tyson
6h 00m
1 stop
MDW12:30 pmChicago Midway
$219
Delta
Feb 25
MDW1:26 pmChicago Midway
6h 29m
1 stop
TYS8:55 pmKnoxville McGhee Tyson
Feb 28
TYS7:38 amKnoxville McGhee Tyson
6h 08m
1 stop
MDW12:46 pmChicago Midway
$239
Delta
Mar 23
MDW9:35 amChicago Midway
6h 08m
1 stop
TYS4:43 pmKnoxville McGhee Tyson
Apr 19
TYS7:00 pmKnoxville McGhee Tyson
4h 28m
1 stop
MDW10:28 pmChicago Midway
$244

momondo Fare Finder

 
Customize your flight search to find flights from Chicago Midway Airport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Chicago Midway Airport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 3/11

3:35 pm-9:10 pm

1 stop4h 35m

Knoxville McGhee Tyson

Tue 3/17

12:30 pm-7:20 pm

1 stop7h 50m

$209

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 3/11

1:20 pm-9:10 pm

2 stops6h 50m

Knoxville McGhee Tyson

Tue 3/17

6:20 pm-10:50 pm

1 stop5h 30m

$214

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 8/5

10:35 am-3:06 pm

1 stop3h 31m

Knoxville McGhee Tyson

Sat 8/8

7:30 am-12:30 pm

1 stop6h 00m

$219

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Sat 3/7

10:15 am-10:10 pm

2 stops10h 55m

Knoxville McGhee Tyson

Mon 3/9

7:25 pm-12:05 am

1 stop5h 40m

$220

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Sun 3/8

8:00 am-9:50 pm

1 stop12h 50m

Knoxville McGhee Tyson

Tue 3/17

4:56 pm-10:19 pm

2 stops30h 23m

$221

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Mon 3/23

9:35 am-4:43 pm

1 stop6h 08m

Knoxville McGhee Tyson

Sun 4/19

7:00 pm-10:28 pm

1 stop4h 28m

$244

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 2/25

6:00 am-11:08 am

1 stop4h 08m

Knoxville McGhee Tyson

Sat 2/28

7:38 am-12:46 pm

1 stop6h 08m

$249

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Sun 3/8

8:00 am-9:50 pm

1 stop12h 50m

Knoxville McGhee Tyson

Sun 3/22

9:43 pm-2:21 pm

1 stop17h 38m

$250

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 3/6

2:41 pm-10:26 pm

2 stops54h 45m

Knoxville McGhee Tyson

Fri 3/13

2:06 pm-11:51 pm

1 stop10h 45m

$251

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Sun 3/8

8:00 am-9:50 pm

1 stop12h 50m

Knoxville McGhee Tyson

Wed 3/25

8:30 am-6:13 pm

1 stop10h 43m

$252

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago Midway Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago Midway Airport to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $252. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago Midway Airport to Knoxville for around $322.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Chicago Midway Airport to Knoxville when you can find flight prices for as low as $266. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $297.

What is the cheapest Chicago Midway to Knoxville McGhee Tyson flight route?

Fly from Chicago Midway to Knoxville McGhee Tyson for the best Chicago Midway - Knoxville McGhee Tyson flight prices

What cabin class options are available on Chicago Midway to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Chicago Midway to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

When to book flights from Chicago Midway Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago Midway Airport to Knoxville (MDW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Knoxville

Fastest flight time

1h 26m

Direct flights

None
The fastest flight from Chicago Midway Airport to Knoxville takes 1h 26m
There are no direct flights from Chicago Midway Airport to Knoxville. There are no popular flight routes from Chicago Midway Airport to Knoxville.
Search flight deals

  • How far is Chicago Midway to Knoxville McGhee Tyson by plane?

    There are 451.6 mi between Chicago Midway and Knoxville McGhee Tyson. Flights usually cover this in 1h 26m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago Midway Airport to Knoxville?

  • What is the most popular airline from Chicago Midway Airport to Knoxville?

Best airlines flying from Chicago Midway Airport to Knoxville

Compare and see reviews for airlines that fly from Chicago Midway Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $75Free CancellationRating
7.2
711 reviews
Search Allegiant Air flights
DeltaPriceFrom $138Free CancellationRating
7.9
8,193 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Chicago.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Chicago on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Chicago to Knoxville?

Once you have performed a search for Chicago to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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