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Cheap flights from Chicago Midway Airport to Knoxville from $131

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago Midway Airport to Knoxville departing on 2/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Chicago Midway Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:00 pm - 11:40 am
MDW
-
TYS
21h 40m1 stop
Multiple Airlines Logo
12:55 pm - 7:52 pm
TYS
-
MDW
7h 57m1 stop
$189Multiple Airlines
Fri, Jan 30 - Fri, Feb 6
Delta Logo
6:25 am - 11:08 am
MDW
-
TYS
3h 43m1 stop
Delta Logo
11:58 am - 3:38 pm
TYS
-
MDW
4h 40m1 stop
$209Delta
Sat, Jan 31 - Sat, Feb 7
Multiple Airlines Logo
9:45 am - 8:39 am
MDW
-
TYS
45h 54m2 stops
Multiple Airlines Logo
12:55 pm - 7:52 pm
TYS
-
MDW
7h 57m1 stop
$216Multiple Airlines
Fri, Jan 30 - Fri, Feb 6
Delta Logo
1:26 pm - 8:47 pm
MDW
-
TYS
6h 21m1 stop
Delta Logo
5:40 am - 9:53 am
TYS
-
MDW
5h 13m1 stop
$224Delta
Thu, Jan 22 - Sun, Jan 25
Delta Logo
1:26 pm - 8:47 pm
MDW
-
TYS
6h 21m1 stop
Delta Logo
7:30 am - 12:46 pm
TYS
-
MDW
6h 16m1 stop
$234Delta
Thu, Jan 29 - Sun, Feb 1
Multiple Airlines Logo
1:00 pm - 11:40 am
MDW
-
TYS
21h 40m1 stop
Multiple Airlines Logo
1:39 pm - 11:45 am
TYS
-
MDW
23h 06m2 stops
$239Multiple Airlines
Fri, Feb 6 - Sun, Feb 8
Southwest Logo
3:00 pm - 7:40 pm
MDW
-
TYS
3h 40m1 stop
Southwest Logo
8:05 am - 12:05 pm
TYS
-
MDW
5h 00m1 stop
$253Southwest
Wed, Apr 15 - Thu, Apr 16
Southwest Logo
10:05 am - 7:40 pm
MDW
-
TYS
8h 35m2 stops
Southwest Logo
8:05 am - 12:05 pm
TYS
-
MDW
5h 00m1 stop
$258Southwest
Wed, Apr 15 - Thu, Apr 16
Delta Logo
9:27 am - 4:49 pm
MDW
-
TYS
6h 22m1 stop
Delta Logo
4:00 pm - 9:45 pm
TYS
-
MDW
6h 45m1 stop
$259Delta
Wed, May 6 - Sun, May 10
Southwest Logo
5:30 am - 2:20 pm
MDW
-
TYS
7h 50m1 stop
Southwest Logo
12:15 pm - 7:00 pm
TYS
-
MDW
7h 45m1 stop
$263Southwest
Wed, Apr 29 - Mon, May 4

Delta flights from Chicago Midway Airport to Knoxville

Our best Delta deals on Chicago Midway Airport to Knoxville flight tickets
Delta
Jan 31
MDW10:46 amChicago Midway
3h 33m
1 stop
TYS3:19 pmKnoxville McGhee Tyson
Feb 7
TYS11:58 amKnoxville McGhee Tyson
4h 40m
1 stop
MDW3:38 pmChicago Midway
$209
Find similar
Delta
Jan 22
MDW1:26 pmChicago Midway
6h 21m
1 stop
TYS8:47 pmKnoxville McGhee Tyson
Jan 25
TYS5:40 amKnoxville McGhee Tyson
5h 13m
1 stop
MDW9:53 amChicago Midway
$224
Find similar
Delta
Jan 29
MDW1:26 pmChicago Midway
6h 21m
1 stop
TYS8:47 pmKnoxville McGhee Tyson
Feb 1
TYS1:00 pmKnoxville McGhee Tyson
5h 55m
1 stop
MDW5:55 pmChicago Midway
$234
Find similar

Southwest flights from Chicago Midway Airport to Knoxville

Our best Southwest deals on Chicago Midway Airport to Knoxville flight tickets
Southwest
Apr 4
MDW11:45 amChicago Midway
5h 50m
1 stop
TYS6:35 pmKnoxville McGhee Tyson
Apr 11
TYS3:55 pmKnoxville McGhee Tyson
6h 10m
1 stop
MDW9:05 pmChicago Midway
$307
Find similar
Southwest
Apr 4
MDW2:40 pmChicago Midway
6h 30m
2 stops
TYS10:10 pmKnoxville McGhee Tyson
Apr 11
TYS3:55 pmKnoxville McGhee Tyson
6h 10m
1 stop
MDW9:05 pmChicago Midway
$312
Find similar
Southwest
Apr 2
MDW2:35 pmChicago Midway
5h 40m
2 stops
TYS9:15 pmKnoxville McGhee Tyson
Apr 5
TYS7:25 pmKnoxville McGhee Tyson
5h 40m
1 stop
MDW12:05 amChicago Midway
$342
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago Midway Airport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 4, 2026.
Use the filters below to find and compare flights from Chicago Midway Airport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 1/30

1:00 pm-11:40 am

1 stop21h 40m

Knoxville McGhee Tyson

Fri 2/6

12:55 pm-7:52 pm

1 stop7h 57m

$189

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Sat 1/31

6:25 am-11:08 am

1 stop3h 43m

Knoxville McGhee Tyson

Sat 2/7

11:58 am-3:38 pm

1 stop4h 40m

$209

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 1/30

9:45 am-8:39 am

2 stops45h 54m

Knoxville McGhee Tyson

Fri 2/6

12:55 pm-7:52 pm

1 stop7h 57m

$216

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 1/22

1:26 pm-8:47 pm

1 stop6h 21m

Knoxville McGhee Tyson

Sun 1/25

5:40 am-9:53 am

1 stop5h 13m

$224

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 1/29

1:26 pm-8:47 pm

1 stop6h 21m

Knoxville McGhee Tyson

Sun 2/1

7:30 am-12:46 pm

1 stop6h 16m

$234

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 2/6

1:00 pm-11:40 am

1 stop21h 40m

Knoxville McGhee Tyson

Sun 2/8

1:39 pm-11:45 am

2 stops23h 06m

$239

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 4/15

3:00 pm-7:40 pm

1 stop3h 40m

Knoxville McGhee Tyson

Thu 4/16

8:05 am-12:05 pm

1 stop5h 00m

$253

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 4/15

10:05 am-7:40 pm

2 stops8h 35m

Knoxville McGhee Tyson

Thu 4/16

8:05 am-12:05 pm

1 stop5h 00m

$258

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 5/6

9:27 am-4:49 pm

1 stop6h 22m

Knoxville McGhee Tyson

Sun 5/10

4:00 pm-9:45 pm

1 stop6h 45m

$259

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Wed 4/29

5:30 am-2:20 pm

1 stop7h 50m

Knoxville McGhee Tyson

Mon 5/4

12:15 pm-7:00 pm

1 stop7h 45m

$263

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago Midway Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago Midway Airport to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $259. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago Midway Airport to Knoxville for around $318.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Chicago Midway Airport to Knoxville when you can find flight prices for as low as $261. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $296.

What is the cheapest Chicago Midway to Knoxville McGhee Tyson flight route?

Fly from Chicago Midway to Knoxville McGhee Tyson for the best Chicago Midway - Knoxville McGhee Tyson flight prices

What cabin class options are available on Chicago Midway to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Chicago Midway to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

When to book flights from Chicago Midway Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago Midway Airport to Knoxville (MDW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Knoxville

Fastest flight time

1h 28m

Direct flights

None
The fastest flight from Chicago Midway Airport to Knoxville takes 1h 28m
There are no direct flights from Chicago Midway Airport to Knoxville. There are no popular flight routes from Chicago Midway Airport to Knoxville.
Search flight deals

  • How far is Chicago Midway to Knoxville McGhee Tyson by plane?

    There are 451.6 mi between Chicago Midway and Knoxville McGhee Tyson. Flights usually cover this in 1h 28m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago Midway Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago Midway Airport to Knoxville?

  • What is the most popular airline from Chicago Midway Airport to Knoxville?

Best airlines flying from Chicago Midway Airport to Knoxville

Compare and see reviews for airlines that fly from Chicago Midway Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $82Free CancellationRating
7.2
701 reviews
Search Allegiant Air flights
DeltaPriceFrom $208Free CancellationRating
7.9
8,017 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Chicago.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Chicago on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Chicago to Knoxville?

Once you have performed a search for Chicago to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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