Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Santiago to San Francisco from $318

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 5/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Santiago to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
6:40 am - 11:55 pm
SCL
-
SFO
20h 15m
2 stops
Avianca Logo
2:15 pm - 2:15 pm
SFO
-
SCL
21h 00m
2 stops
$606Avianca
Tue, Apr 21 - Wed, Apr 29
Avianca Logo
6:40 am - 10:35 pm
SCL
-
SFO
18h 55m
2 stops
Avianca Logo
11:55 pm - 11:20 pm
SFO
-
SCL
20h 25m
2 stops
$607Avianca
Fri, Apr 24 - Mon, May 11
LATAM Airlines Logo
8:40 pm - 10:37 am
SCL
-
SFO
16h 57m
1 stop
LATAM Airlines Logo
6:00 am - 7:15 am
SFO
-
SCL
22h 15m
1 stop
$610LATAM Airlines
Sun, May 3 - Wed, May 27
Avianca Logo
6:40 am - 10:35 pm
SCL
-
SFO
18h 55m
2 stops
Avianca Logo
11:55 pm - 11:20 pm
SFO
-
SCL
20h 25m
2 stops
$614Avianca
Fri, Apr 24 - Fri, May 8
Avianca Logo
6:40 am - 10:35 pm
SCL
-
SFO
18h 55m
2 stops
Avianca Logo
2:15 pm - 2:15 pm
SFO
-
SCL
21h 00m
2 stops
$616Avianca
Fri, May 8 - Sun, May 17
Avianca Logo
6:40 am - 10:35 pm
SCL
-
SFO
18h 55m
2 stops
Avianca Logo
2:15 pm - 2:15 pm
SFO
-
SCL
21h 00m
2 stops
$617Avianca
Wed, May 20 - Tue, May 26
LATAM Airlines Logo
11:25 pm - 1:27 pm
SCL
-
SFO
17h 02m
1 stop
LATAM Airlines Logo
7:15 am - 5:25 am
SFO
-
SCL
19h 10m
2 stops
$621LATAM Airlines
Fri, Apr 24 - Mon, May 11
Copa Airlines Logo
4:17 am - 11:40 pm
SCL
-
SFO
22h 23m
1 stop
Copa Airlines Logo
8:16 pm - 7:23 pm
SFO
-
SCL
20h 07m
1 stop
$623Copa Airlines
Thu, Apr 16 - Sat, May 2
LATAM Airlines Logo
8:40 pm - 10:37 am
SCL
-
SFO
16h 57m
1 stop
LATAM Airlines Logo
11:59 pm - 1:35 pm
SFO
-
SCL
34h 36m
2 stops
$624LATAM Airlines
Sun, May 3 - Wed, May 27
Avianca Logo
6:40 am - 10:35 pm
SCL
-
SFO
18h 55m
2 stops
Avianca Logo
2:15 pm - 2:15 pm
SFO
-
SCL
21h 00m
2 stops
$626Avianca
Sun, May 3 - Wed, May 27

Avianca flights from Santiago to San Francisco

Our best Avianca deals on Santiago to San Francisco flight tickets
Avianca
Apr 21
SCL6:40 amSantiago Arturo Merino Benitez
20h 15m
2 stops
SFO11:55 pmSan Francisco
Apr 29
SFO2:15 pmSan Francisco
21h 00m
2 stops
SCL2:15 pmSantiago Arturo Merino Benitez
$606
Avianca
Apr 24
SCL6:40 amSantiago Arturo Merino Benitez
18h 55m
2 stops
SFO10:35 pmSan Francisco
May 11
SFO11:55 pmSan Francisco
20h 25m
2 stops
SCL11:20 pmSantiago Arturo Merino Benitez
$607
Avianca
Apr 21
SCL6:40 amSantiago Arturo Merino Benitez
20h 15m
2 stops
SFO11:55 pmSan Francisco
Apr 29
SFO2:15 pmSan Francisco
21h 00m
2 stops
SCL2:15 pmSantiago Arturo Merino Benitez
$610

American Airlines flights from Santiago to San Francisco

Our best American Airlines deals on Santiago to San Francisco flight tickets
American Airlines
Apr 27
SCL8:35 pmSantiago Arturo Merino Benitez
27h 21m
1 stop
SFO8:56 pmSan Francisco
May 1
SFO1:12 pmSan Francisco
14h 53m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
$628
American Airlines
Apr 27
SCL8:35 pmSantiago Arturo Merino Benitez
24h 05m
2 stops
SFO5:40 pmSan Francisco
May 1
SFO1:12 pmSan Francisco
14h 53m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
$633
American Airlines
Apr 27
SCL8:35 pmSantiago Arturo Merino Benitez
17h 27m
1 stop
SFO11:02 amSan Francisco
May 4
SFO1:12 pmSan Francisco
14h 53m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
$635

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 18, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 4/21

6:40 am-11:55 pm

2 stops20h 15m

San Francisco

Wed 4/29

2:15 pm-2:15 pm

2 stops21h 00m

$606

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 4/24

6:40 am-10:35 pm

2 stops18h 55m

San Francisco

Mon 5/11

11:55 pm-11:20 pm

2 stops20h 25m

$607

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sun 5/3

8:40 pm-10:37 am

1 stop16h 57m

San Francisco

Wed 5/27

6:00 am-7:15 am

1 stop22h 15m

$610

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 4/24

6:40 am-10:35 pm

2 stops18h 55m

San Francisco

Fri 5/8

11:55 pm-11:20 pm

2 stops20h 25m

$614

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 5/8

6:40 am-10:35 pm

2 stops18h 55m

San Francisco

Sun 5/17

2:15 pm-2:15 pm

2 stops21h 00m

$616

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 5/20

6:40 am-10:35 pm

2 stops18h 55m

San Francisco

Tue 5/26

2:15 pm-2:15 pm

2 stops21h 00m

$617
Quickest round-trip

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 4/24

11:25 pm-1:27 pm

1 stop17h 02m

San Francisco

Mon 5/11

7:15 am-5:25 am

2 stops19h 10m

$621

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 4/16

4:17 am-11:40 pm

1 stop22h 23m

San Francisco

Sat 5/2

8:16 pm-7:23 pm

1 stop20h 07m

$623

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sun 5/3

8:40 pm-10:37 am

1 stop16h 57m

San Francisco

Wed 5/27

11:59 pm-1:35 pm

2 stops34h 36m

$624

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sun 5/3

6:40 am-10:35 pm

2 stops18h 55m

San Francisco

Wed 5/27

2:15 pm-2:15 pm

2 stops21h 00m

$626

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $570.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $640 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $569 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 7% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of March 2026, prices for Santiago to San Francisco flights are approximately 11% cheaper when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Fastest flight time

15h 15m

Direct flights

None
The fastest flight from Santiago to San Francisco takes 15h 15m
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
Search flight deals

  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5935.3 mi. 15h 15m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $433Free CancellationRating
6.5
2,499 reviews
Search Avianca flights
American AirlinesPriceFrom $481Free CancellationRating
7.1
11,467 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $508Free CancellationRating
7.4
1,914 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $511Free CancellationRating
7.5
1,569 reviews
Search Copa Airlines flights
DeltaPriceFrom $547Free CancellationRating
7.9
8,288 reviews
Search Delta flights
United AirlinesPriceFrom $571Free CancellationRating
7.4
9,434 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Roseville
Hayward
Berkeley
Santa Clara
Big Sur
Fremont
Calistoga
Vallejo
Salinas
Half Moon Bay
Daly City
Milpitas
Pacific Grove
South San Francisco

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Fri 4/17
Fri 4/24
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States