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Cheap flights from Santiago to San Francisco from $309

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 10/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santiago to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
6:40 am - 11:55 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
20h 15m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
2:15 pm - 2:15 pmSFO  San Francisco-SCL Santiago Arturo Merino Benitez
21h 00m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$604Avianca
Thu, Aug 20 - Sat, Aug 29
Avianca Logo
6:40 am - 10:35 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
18h 55m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
11:55 pm - 11:20 pmSFO  San Francisco-SCL Santiago Arturo Merino Benitez
20h 25m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$604Avianca
Mon, Aug 24 - Thu, Sep 3
LATAM Airlines Logo
7:30 am - 9:23 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
18h 53m2 stops Lima J Chavez Intl Los Angeles
LATAM Airlines Logo
7:05 am - 5:35 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
17h 30m1 stop Los Angeles
$633LATAM Airlines
Mon, Nov 16 - Mon, Nov 23
LATAM Airlines Logo
7:30 am - 9:23 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
18h 53m2 stops Lima J Chavez Intl Los Angeles
LATAM Airlines Logo
8:00 am - 7:00 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
18h 00m2 stops Atlanta Hartsfield-Jackson Miami
$638LATAM Airlines
Mon, Nov 9 - Thu, Nov 12
Copa Airlines Logo
1:44 am - 11:40 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
25h 56m1 stop Panama City Tocumen Intl
Copa Airlines Logo
7:36 pm - 11:35 pmSFO  San Francisco-SCL Santiago Arturo Merino Benitez
22h 59m1 stop Panama City Tocumen Intl
$663Copa Airlines
Wed, Sep 30 - Wed, Dec 2
Copa Airlines Logo
1:22 am - 5:25 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
21h 03m1 stop Panama City Tocumen Intl
Copa Airlines Logo
12:33 am - 11:36 pmSFO  San Francisco-SCL Santiago Arturo Merino Benitez
18h 03m1 stop Panama City Tocumen Intl
$663Copa Airlines
Tue, Nov 10 - Tue, Nov 17
Multiple Airlines Logo
11:55 pm - 10:53 amSCL  Santiago Arturo Merino Benitez-SFO San Francisco
14h 58m1 stop Los Angeles
Multiple Airlines Logo
10:21 am - 5:35 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
15h 14m1 stop Los Angeles
$665Multiple Airlines
Thu, Oct 1 - Thu, Oct 8
Multiple Airlines Logo
11:55 pm - 10:53 amSCL  Santiago Arturo Merino Benitez-SFO San Francisco
14h 58m1 stop Los Angeles
Multiple Airlines Logo
8:00 am - 5:35 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
16h 35m1 stop Los Angeles
$665Multiple Airlines
Wed, Sep 30 - Mon, Dec 7
United Airlines Logo
10:45 pm - 8:58 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
26h 13m1 stop Houston George Bush Intcntl
United Airlines Logo
6:35 pm - 8:50 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
33h 15m1 stop Houston George Bush Intcntl
$666United Airlines
Sat, Oct 31 - Sat, Nov 7
United Airlines Logo
10:45 pm - 1:19 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
18h 34m1 stop Houston George Bush Intcntl
United Airlines Logo
11:59 pm - 8:50 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
27h 51m1 stop Houston George Bush Intcntl
$667United Airlines
Sat, Oct 31 - Sun, Nov 8

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Avianca flights from Santiago to San Francisco

Our best Avianca deals on Santiago to San Francisco flight tickets
Avianca
Aug 25
SCL6:40 amSantiago Arturo Merino Benitez
18h 55m
2 stops
SFO10:35 pmSan Francisco
Sep 7
SFO11:55 pmSan Francisco
20h 25m
2 stops
SCL12:20 amSantiago Arturo Merino Benitez
$604
Avianca
Aug 25
SCL6:40 amSantiago Arturo Merino Benitez
18h 55m
2 stops
SFO10:35 pmSan Francisco
Jan 22
SFO11:10 pmSan Francisco
20h 20m
2 stops
SCL12:30 amSantiago Arturo Merino Benitez
$605
Avianca
Sep 1
SCL6:40 amSantiago Arturo Merino Benitez
20h 15m
2 stops
SFO11:55 pmSan Francisco
Sep 4
SFO11:55 pmSan Francisco
20h 25m
2 stops
SCL11:20 pmSantiago Arturo Merino Benitez
$608

Copa Airlines flights from Santiago to San Francisco

Our best Copa Airlines deals on Santiago to San Francisco flight tickets
Copa Airlines
Oct 8
SCL5:15 amSantiago Arturo Merino Benitez
16h 55m
1 stop
SFO6:10 pmSan Francisco
Dec 9
SFO7:36 pmSan Francisco
22h 59m
1 stop
SCL11:35 pmSantiago Arturo Merino Benitez
$663
Copa Airlines
Oct 6
SCL5:15 amSantiago Arturo Merino Benitez
22h 25m
1 stop
SFO11:40 pmSan Francisco
Oct 14
SFO8:21 pmSan Francisco
27h 35m
1 stop
SCL3:56 amSantiago Arturo Merino Benitez
$683
Copa Airlines
Nov 9
SCL12:15 pmSantiago Arturo Merino Benitez
15h 57m
1 stop
SFO11:12 pmSan Francisco
Nov 12
SFO7:36 pmSan Francisco
23h 43m
1 stop
SCL12:19 amSantiago Arturo Merino Benitez
$686

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Thu 8/20

6:40 am-11:55 pm

2 stops20h 15m

San Francisco

Sat 8/29

2:15 pm-2:15 pm

2 stops21h 00m

$604

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Mon 8/24

6:40 am-10:35 pm

2 stops18h 55m

San Francisco

Thu 9/3

11:55 pm-11:20 pm

2 stops20h 25m

$604

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Mon 11/16

7:30 am-9:23 pm

2 stops18h 53m

San Francisco

Mon 11/23

7:05 am-5:35 am

1 stop17h 30m

$633

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Mon 11/9

7:30 am-9:23 pm

2 stops18h 53m

San Francisco

Thu 11/12

8:00 am-7:00 am

2 stops18h 00m

$638

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Wed 9/30

1:44 am-11:40 pm

1 stop25h 56m

San Francisco

Wed 12/2

7:36 pm-11:35 pm

1 stop22h 59m

$663

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Tue 11/10

1:22 am-5:25 pm

1 stop21h 03m

San Francisco

Tue 11/17

12:33 am-11:36 pm

1 stop18h 03m

$663
Quickest round-trip

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Thu 10/1

11:55 pm-10:53 am

1 stop14h 58m

San Francisco

Thu 10/8

10:21 am-5:35 am

1 stop15h 14m

$665

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Wed 9/30

11:55 pm-10:53 am

1 stop14h 58m

San Francisco

Mon 12/7

8:00 am-5:35 am

1 stop16h 35m

$665

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Sat 10/31

10:45 pm-8:58 pm

1 stop26h 13m

San Francisco

Sat 11/7

6:35 pm-8:50 am

1 stop33h 15m

$666

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Sat 10/31

10:45 pm-1:19 pm

1 stop18h 34m

San Francisco

Sun 11/8

11:59 pm-8:50 am

1 stop27h 51m

$667

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santiago and San Francisco?

Prices are currently typical for flights on this route.

Typical prices usually range from $578 to $806.
The lowest price recently found on this route was $604.

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in November is also cheap. Prices for this month can be found on momondo for an average of $568.

How far in advance should I book a flight from Santiago to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $655 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $568 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 41% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of August 2026, prices for Santiago to San Francisco flights are approximately 2% more expensive when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Fastest flight time

18h 34m

Direct flights

None
The fastest flight from Santiago to San Francisco takes 18h 34m
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
Search flight deals

Frequently asked questions about flying from Santiago to San Francisco

  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5934.4 mi. 18h 34m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $311Free CancellationRating
7.6
1,563 reviews
Search Copa Airlines flights
AviancaPriceFrom $433Free CancellationRating
6.5
2,530 reviews
Search Avianca flights
American AirlinesPriceFrom $481Free CancellationRating
7.1
11,899 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $501Free CancellationRating
7.4
1,975 reviews
Search LATAM Airlines flights
DeltaPriceFrom $509Free CancellationRating
7.8
8,497 reviews
Search Delta flights
United AirlinesPriceFrom $571Free CancellationRating
7.4
10,098 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Fremont
Berkeley
Bodega Bay
Hayward
Walnut Creek
Santa Clara
Vallejo
Roseville
Sonoma
Salinas
Sunnyvale
Milpitas
Daly City
Burlingame
Marina
Palo Alto

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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