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Cheap flights from Santiago to San Francisco from $280

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 8/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santiago to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
11:22 am - 11:40 pm
SCL
-
SFO
15h 18m
1 stop
Copa Airlines Logo
8:21 pm - 11:26 pm
SFO
-
SCL
24h 05m
1 stop
$568Copa Airlines
Tue, Aug 18 - Sun, Aug 23
Delta Logo
11:00 pm - 7:39 pm
SCL
-
SFO
23h 39m
2 stops
Delta Logo
9:30 am - 5:35 am
SFO
-
SCL
16h 05m
1 stop
$571Delta
Tue, Aug 25 - Mon, Sep 7
Avianca Logo
3:20 pm - 12:50 pm
SCL
-
SFO
24h 30m
2 stops
Avianca Logo
2:15 pm - 2:15 pm
SFO
-
SCL
21h 00m
2 stops
$573Avianca
Thu, Jul 23 - Tue, Jul 28
Avianca Logo
6:40 am - 10:35 pm
SCL
-
SFO
18h 55m
2 stops
Avianca Logo
7:45 am - 2:15 pm
SFO
-
SCL
27h 30m
3 stops
$574Avianca
Wed, Aug 12 - Tue, Aug 18
Avianca Logo
6:40 am - 10:35 pm
SCL
-
SFO
18h 55m
2 stops
Avianca Logo
7:45 am - 2:15 pm
SFO
-
SCL
27h 30m
3 stops
$575Avianca
Tue, Aug 18 - Tue, Aug 25
Delta Logo
11:00 pm - 7:39 pm
SCL
-
SFO
23h 39m
2 stops
Delta Logo
8:00 am - 6:55 am
SFO
-
SCL
19h 55m
2 stops
$577Delta
Tue, Aug 4 - Wed, Aug 26
Avianca Logo
6:40 am - 10:35 pm
SCL
-
SFO
42h 55m
2 stops
Avianca Logo
7:45 am - 11:20 pm
SFO
-
SCL
36h 35m
3 stops
$578Avianca
Thu, Jul 23 - Mon, Aug 10
Delta Logo
11:00 pm - 7:39 pm
SCL
-
SFO
23h 39m
2 stops
Delta Logo
10:00 pm - 7:45 pm
SFO
-
SCL
18h 45m
2 stops
$579Delta
Mon, Aug 24 - Wed, Sep 2
American Airlines Logo
8:50 pm - 10:34 am
SCL
-
SFO
16h 44m
1 stop
American Airlines Logo
11:45 am - 7:05 am
SFO
-
SCL
16h 20m
1 stop
$580American Airlines
Thu, Aug 20 - Fri, Sep 4
American Airlines Logo
9:00 pm - 8:20 pm
SCL
-
SFO
26h 20m
1 stop
American Airlines Logo
7:30 am - 7:05 am
SFO
-
SCL
20h 35m
1 stop
$583American Airlines
Wed, Jul 29 - Wed, Aug 12

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Copa Airlines flights from Santiago to San Francisco

Our best Copa Airlines deals on Santiago to San Francisco flight tickets
Copa Airlines
Aug 18
SCL11:22 amSantiago Arturo Merino Benitez
15h 18m
1 stop
SFO11:40 pmSan Francisco
Aug 23
SFO8:21 pmSan Francisco
24h 05m
1 stop
SCL11:26 pmSantiago Arturo Merino Benitez
$568
Copa Airlines
Aug 13
SCL2:14 amSantiago Arturo Merino Benitez
24h 26m
1 stop
SFO11:40 pmSan Francisco
Aug 27
SFO1:12 amSan Francisco
22h 48m
1 stop
SCL3:00 amSantiago Arturo Merino Benitez
$614
Copa Airlines
Aug 25
SCL11:22 amSantiago Arturo Merino Benitez
15h 18m
1 stop
SFO11:40 pmSan Francisco
Aug 30
SFO1:12 amSan Francisco
15h 24m
1 stop
SCL7:36 pmSantiago Arturo Merino Benitez
$622

Avianca flights from Santiago to San Francisco

Our best Avianca deals on Santiago to San Francisco flight tickets
Avianca
Jul 23
SCL3:20 pmSantiago Arturo Merino Benitez
24h 30m
2 stops
SFO12:50 pmSan Francisco
Jul 28
SFO2:15 pmSan Francisco
21h 00m
2 stops
SCL2:15 pmSantiago Arturo Merino Benitez
$573
Avianca
Aug 12
SCL6:40 amSantiago Arturo Merino Benitez
18h 55m
2 stops
SFO10:35 pmSan Francisco
Aug 18
SFO7:45 amSan Francisco
27h 30m
3 stops
SCL2:15 pmSantiago Arturo Merino Benitez
$574
Avianca
Aug 18
SCL6:40 amSantiago Arturo Merino Benitez
18h 55m
2 stops
SFO10:35 pmSan Francisco
Aug 25
SFO7:45 amSan Francisco
27h 30m
3 stops
SCL2:15 pmSantiago Arturo Merino Benitez
$575

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 8/18

11:22 am-11:40 pm

1 stop15h 18m

San Francisco

Sun 8/23

8:21 pm-11:26 pm

1 stop24h 05m

$568

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 8/25

11:00 pm-7:39 pm

2 stops23h 39m

San Francisco

Mon 9/7

9:30 am-5:35 am

1 stop16h 05m

$571

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 7/23

3:20 pm-12:50 pm

2 stops24h 30m

San Francisco

Tue 7/28

2:15 pm-2:15 pm

2 stops21h 00m

$573

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 8/12

6:40 am-10:35 pm

2 stops18h 55m

San Francisco

Tue 8/18

7:45 am-2:15 pm

3 stops27h 30m

$574

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 8/18

6:40 am-10:35 pm

2 stops18h 55m

San Francisco

Tue 8/25

7:45 am-2:15 pm

3 stops27h 30m

$575

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 8/4

11:00 pm-7:39 pm

2 stops23h 39m

San Francisco

Wed 8/26

8:00 am-6:55 am

2 stops19h 55m

$577

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 7/23

6:40 am-10:35 pm

2 stops42h 55m

San Francisco

Mon 8/10

7:45 am-11:20 pm

3 stops36h 35m

$578

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 8/24

11:00 pm-7:39 pm

2 stops23h 39m

San Francisco

Wed 9/2

10:00 pm-7:45 pm

2 stops18h 45m

$579
Quickest round-trip

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 8/20

8:50 pm-10:34 am

1 stop16h 44m

San Francisco

Fri 9/4

11:45 am-7:05 am

1 stop16h 20m

$580

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 7/29

9:00 pm-8:20 pm

1 stop26h 20m

San Francisco

Wed 8/12

7:30 am-7:05 am

1 stop20h 35m

$583

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santiago and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in February is also cheap. Prices for this month can be found on momondo for an average of $577.

How far in advance should I book a flight from Santiago to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $651 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $588 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 41% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of June 2026, prices for Santiago to San Francisco flights are approximately 83% more expensive when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Fastest flight time

16h 49m

Direct flights

None
The fastest flight from Santiago to San Francisco takes 16h 49m
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
Search flight deals

Frequently asked questions about flying from Santiago to San Francisco

  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5934.4 mi. 16h 49m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $311Free CancellationRating
7.5
1,568 reviews
Search Copa Airlines flights
AviancaPriceFrom $408Free CancellationRating
6.5
2,530 reviews
Search Avianca flights
American AirlinesPriceFrom $481Free CancellationRating
7.1
11,660 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $501Free CancellationRating
7.4
1,933 reviews
Search LATAM Airlines flights
DeltaPriceFrom $559Free CancellationRating
7.9
8,400 reviews
Search Delta flights
United AirlinesPriceFrom $571Free CancellationRating
7.4
9,841 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Hayward
Bodega Bay
Roseville
Walnut Creek
Santa Clara
Berkeley
Fremont
Vallejo
South San Francisco
Sunnyvale
Big Sur
Pacific Grove
Salinas
Daly City
Calistoga
Burlingame

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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