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Cheap flights from Santiago to San Francisco from $280

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 10/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Avianca Logo
7:10 am - 10:45 pmSCL-SFO
19h 35m2 stops
Avianca Logo
12:05 am - 11:30 pmSFO-SCL
19h 25m2 stops
$512Avianca
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Mon, Sep 29 - Sat, Oct 11
American Airlines Logo
11:15 pm - 3:03 pmSCL-SFO
20h 48m1 stop
American Airlines Logo
6:10 am - 7:50 amSFO-SCL
20h 40m1 stop
$525American Airlines
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Mon, Nov 17 - Mon, Jan 26
Delta Logo
9:00 am - 11:50 pmSCL-SFO
18h 50m2 stops
Delta Logo
5:50 am - 6:00 amSFO-SCL
20h 10m2 stops
$535Delta
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Thu, Sep 25 - Wed, Oct 8
United Airlines Logo
10:45 pm - 10:59 pmSCL-SFO
29h 14m1 stop
United Airlines Logo
11:59 pm - 8:50 amSFO-SCL
27h 51m1 stop
$539United Airlines
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Wed, Nov 12 - Sun, Nov 30
Copa Airlines Logo
3:23 am - 11:17 pmSCL-SFO
24h 54m1 stop
Copa Airlines Logo
12:36 am - 12:06 amSFO-SCL
18h 30m1 stop
$542Copa Airlines
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Wed, Nov 5 - Sat, Nov 15
LATAM Airlines Logo
12:10 am - 10:34 amSCL-SFO
38h 24m2 stops
LATAM Airlines Logo
11:58 am - 7:00 amSFO-SCL
15h 02m1 stop
$547LATAM Airlines
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Wed, Sep 24 - Tue, Oct 7
LATAM Airlines Logo
12:10 am - 6:48 pmSCL-SFO
22h 38m2 stops
LATAM Airlines Logo
6:10 am - 7:00 amSFO-SCL
20h 50m1 stop
$548LATAM Airlines
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Wed, Sep 24 - Wed, Oct 8
Delta Logo
12:55 am - 6:56 pmSCL-SFO
23h 01m2 stops
Delta Logo
10:39 am - 6:00 amSFO-SCL
14h 21m1 stop
$570Delta
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Wed, Nov 5 - Sun, Nov 16
United Airlines Logo
10:45 pm - 5:47 pmSCL-SFO
24h 02m1 stop
United Airlines Logo
12:43 am - 8:50 amSFO-SCL
27h 07m1 stop
$573United Airlines
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Tue, Nov 25 - Fri, Jan 30
Copa Airlines Logo
5:11 am - 11:25 pmSCL-SFO
22h 14m1 stop
Copa Airlines Logo
1:31 am - 12:04 amSFO-SCL
18h 33m1 stop
$637Copa Airlines
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Mon, Sep 29 - Tue, Oct 14

American Airlines flights from Santiago to San Francisco

Our best American Airlines deals on Santiago to San Francisco flight tickets
American Airlines
Sep 25
SCL9:55 pmSantiago Arturo Merino Benitez
19h 10m
1 stop
SFO1:05 pmSan Francisco
Oct 8
SFO12:27 pmSan Francisco
15h 33m
1 stop
SCL8:00 amSantiago Arturo Merino Benitez
$525
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American Airlines
Oct 28
SCL10:15 pmSantiago Arturo Merino Benitez
16h 10m
1 stop
SFO10:25 amSan Francisco
Nov 4
SFO8:00 amSan Francisco
20h 00m
1 stop
SCL9:00 amSantiago Arturo Merino Benitez
$526
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American Airlines
Sep 25
SCL9:55 pmSantiago Arturo Merino Benitez
19h 10m
1 stop
SFO1:05 pmSan Francisco
Oct 8
SFO12:27 pmSan Francisco
15h 33m
1 stop
SCL8:00 amSantiago Arturo Merino Benitez
$527
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Delta flights from Santiago to San Francisco

Our best Delta deals on Santiago to San Francisco flight tickets
Delta
Sep 25
SCL9:40 pmSantiago Arturo Merino Benitez
18h 15m
1 stop
SFO11:55 amSan Francisco
Oct 8
SFO6:10 amSan Francisco
20h 40m
2 stops
SCL6:50 amSantiago Arturo Merino Benitez
$535
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Delta
Nov 5
SCL12:55 amSantiago Arturo Merino Benitez
23h 01m
2 stops
SFO6:56 pmSan Francisco
Nov 16
SFO10:39 amSan Francisco
14h 21m
1 stop
SCL6:00 amSantiago Arturo Merino Benitez
$570
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Delta
Oct 5
SCL9:40 pmSantiago Arturo Merino Benitez
25h 16m
1 stop
SFO6:56 pmSan Francisco
Oct 14
SFO7:15 amSan Francisco
19h 45m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
$575
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momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 9/29

7:10 am-10:45 pm

2 stops19h 35m

San Francisco

Sat 10/11

12:05 am-11:30 pm

2 stops19h 25m

$512

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 11/17

11:15 pm-3:03 pm

1 stop20h 48m

San Francisco

Mon 1/26

6:10 am-7:50 am

1 stop20h 40m

$525

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 9/25

9:00 am-11:50 pm

2 stops18h 50m

San Francisco

Wed 10/8

5:50 am-6:00 am

2 stops20h 10m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 11/12

10:45 pm-10:59 pm

1 stop29h 14m

San Francisco

Sun 11/30

11:59 pm-8:50 am

1 stop27h 51m

$539

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 11/5

3:23 am-11:17 pm

1 stop24h 54m

San Francisco

Sat 11/15

12:36 am-12:06 am

1 stop18h 30m

$542

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 9/24

12:10 am-10:34 am

2 stops38h 24m

San Francisco

Tue 10/7

11:58 am-7:00 am

1 stop15h 02m

$547

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 9/24

12:10 am-6:48 pm

2 stops22h 38m

San Francisco

Wed 10/8

6:10 am-7:00 am

1 stop20h 50m

$548

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 11/5

12:55 am-6:56 pm

2 stops23h 01m

San Francisco

Sun 11/16

10:39 am-6:00 am

1 stop14h 21m

$570

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 11/25

10:45 pm-5:47 pm

1 stop24h 02m

San Francisco

Fri 1/30

12:43 am-8:50 am

1 stop27h 07m

$573

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 9/29

5:11 am-11:25 pm

1 stop22h 14m

San Francisco

Tue 10/14

1:31 am-12:04 am

1 stop18h 33m

$637

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of September, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $584.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Santiago to San Francisco is on a Saturday when prices can be found for as low as $663. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $834.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Santiago to San Francisco flights are usually those with departure times in the afternoon. Our users have found flights to San Francisco in the afternoon for as low as $565. Flights in the evening are often more expensive with an average ticket price of $822.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $680 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $577 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 34% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of September 2025, prices for Santiago to San Francisco flights are approximately 13% cheaper when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Direct flights

None
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
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  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5935.3 mi. 14h 49m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $433Free CancellationRating
6.7
2,435 reviews
Search Avianca flights
Copa AirlinesPriceFrom $520Free CancellationRating
7.6
1,531 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $532Free CancellationRating
7.4
8,929 reviews
Search United Airlines flights
LATAM AirlinesPriceFrom $542Free CancellationRating
7.5
1,847 reviews
Search LATAM Airlines flights
DeltaPriceFrom $551Free CancellationRating
7.9
7,954 reviews
Search Delta flights
American AirlinesPriceFrom $612Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Calistoga
Bodega Bay
Roseville
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Half Moon Bay
Walnut Creek
Vallejo
Redwood City
Salinas
South San Francisco
Fairfield

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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