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Cheap flights from Santiago to San Francisco from $306

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 10/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santiago to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
10:55 pm - 8:03 pm
SCL
-
SFO
24h 08m
1 stop
Delta Logo
6:00 am - 6:55 am
SFO
-
SCL
21h 55m
2 stops
$541Delta
Mon, Aug 10 - Thu, Aug 13
Delta Logo
11:00 pm - 3:42 pm
SCL
-
SFO
19h 42m
2 stops
Delta Logo
6:00 am - 6:55 am
SFO
-
SCL
21h 55m
2 stops
$541Delta
Mon, Aug 10 - Thu, Aug 13
LATAM Airlines Logo
11:00 pm - 11:58 pm
SCL
-
SFO
27h 58m
2 stops
LATAM Airlines Logo
1:45 pm - 9:15 pm
SFO
-
SCL
28h 30m
3 stops
$551LATAM Airlines
Mon, Aug 10 - Thu, Aug 13
LATAM Airlines Logo
11:10 pm - 5:11 pm
SCL
-
SFO
23h 01m
1 stop
LATAM Airlines Logo
11:59 pm - 5:35 am
SFO
-
SCL
24h 36m
2 stops
$551LATAM Airlines
Tue, Nov 24 - Mon, Nov 30
Avianca Logo
6:40 am - 11:55 pm
SCL
-
SFO
20h 15m
2 stops
Avianca Logo
11:55 pm - 11:20 pm
SFO
-
SCL
20h 25m
2 stops
$599Avianca
Tue, Sep 1 - Thu, Sep 3
Avianca Logo
6:40 am - 10:35 pm
SCL
-
SFO
18h 55m
2 stops
Avianca Logo
2:15 pm - 2:15 pm
SFO
-
SCL
21h 00m
2 stops
$599Avianca
Wed, Aug 26 - Wed, Sep 2
Copa Airlines Logo
1:43 am - 11:40 pm
SCL
-
SFO
25h 57m
1 stop
Copa Airlines Logo
8:21 pm - 3:56 am
SFO
-
SCL
27h 35m
1 stop
$658Copa Airlines
Thu, Sep 17 - Sun, Oct 4
Copa Airlines Logo
12:23 pm - 6:10 pm
SCL
-
SFO
33h 47m
1 stop
Copa Airlines Logo
8:21 pm - 11:39 pm
SFO
-
SCL
23h 18m
1 stop
$663Copa Airlines
Tue, Oct 6 - Sun, Oct 18
United Airlines Logo
9:45 pm - 10:10 am
SCL
-
SFO
16h 25m
1 stop
United Airlines Logo
11:59 pm - 8:50 am
SFO
-
SCL
27h 51m
1 stop
$663United Airlines
Sun, Oct 25 - Sun, Nov 1
United Airlines Logo
9:45 pm - 6:32 pm
SCL
-
SFO
24h 47m
1 stop
United Airlines Logo
7:05 am - 8:50 am
SFO
-
SCL
20h 45m
1 stop
$666United Airlines
Sun, Oct 25 - Sun, Nov 1

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Delta flights from Santiago to San Francisco

Our best Delta deals on Santiago to San Francisco flight tickets
Delta
Aug 10
SCL11:00 pmSantiago Arturo Merino Benitez
19h 42m
2 stops
SFO3:42 pmSan Francisco
Aug 13
SFO6:00 amSan Francisco
21h 55m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
$541
Delta
Sep 18
SCL11:55 pmSantiago Arturo Merino Benitez
14h 58m
1 stop
SFO10:53 amSan Francisco
Oct 4
SFO7:20 amSan Francisco
18h 30m
2 stops
SCL5:50 amSantiago Arturo Merino Benitez
$665
Delta
Oct 6
SCL8:40 pmSantiago Arturo Merino Benitez
26h 57m
1 stop
SFO7:37 pmSan Francisco
Oct 14
SFO7:30 amSan Francisco
19h 25m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
$666

LATAM Airlines flights from Santiago to San Francisco

Our best LATAM Airlines deals on Santiago to San Francisco flight tickets
LATAM Airlines
Nov 24
SCL11:10 pmSantiago Arturo Merino Benitez
23h 01m
1 stop
SFO5:11 pmSan Francisco
Nov 30
SFO11:59 pmSan Francisco
24h 36m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
$551
LATAM Airlines
Sep 28
SCL11:55 pmSantiago Arturo Merino Benitez
19h 54m
2 stops
SFO3:49 pmSan Francisco
Oct 6
SFO7:05 amSan Francisco
18h 30m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
$628
LATAM Airlines
Dec 11
SCL8:40 amSantiago Arturo Merino Benitez
17h 43m
2 stops
SFO9:23 pmSan Francisco
Mar 29
SFO7:00 amSan Francisco
18h 35m
1 stop
SCL5:35 amSantiago Arturo Merino Benitez
$653

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 27, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 8/10

10:55 pm-8:03 pm

1 stop24h 08m

San Francisco

Thu 8/13

6:00 am-6:55 am

2 stops21h 55m

$541

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 8/10

11:00 pm-3:42 pm

2 stops19h 42m

San Francisco

Thu 8/13

6:00 am-6:55 am

2 stops21h 55m

$541

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 8/10

11:00 pm-11:58 pm

2 stops27h 58m

San Francisco

Thu 8/13

1:45 pm-9:15 pm

3 stops28h 30m

$551

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 11/24

11:10 pm-5:11 pm

1 stop23h 01m

San Francisco

Mon 11/30

11:59 pm-5:35 am

2 stops24h 36m

$551

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 9/1

6:40 am-11:55 pm

2 stops20h 15m

San Francisco

Thu 9/3

11:55 pm-11:20 pm

2 stops20h 25m

$599
Quickest round-trip

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 8/26

6:40 am-10:35 pm

2 stops18h 55m

San Francisco

Wed 9/2

2:15 pm-2:15 pm

2 stops21h 00m

$599

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 9/17

1:43 am-11:40 pm

1 stop25h 57m

San Francisco

Sun 10/4

8:21 pm-3:56 am

1 stop27h 35m

$658

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 10/6

12:23 pm-6:10 pm

1 stop33h 47m

San Francisco

Sun 10/18

8:21 pm-11:39 pm

1 stop23h 18m

$663

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sun 10/25

9:45 pm-10:10 am

1 stop16h 25m

San Francisco

Sun 11/1

11:59 pm-8:50 am

1 stop27h 51m

$663

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sun 10/25

9:45 pm-6:32 pm

1 stop24h 47m

San Francisco

Sun 11/1

7:05 am-8:50 am

1 stop20h 45m

$666

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santiago and San Francisco?

Prices are currently low for flights on this route.

Typical prices usually range from $577 to $787.
The lowest price recently found on this route was $541.

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in November is also cheap. Prices for this month can be found on momondo for an average of $557.

How far in advance should I book a flight from Santiago to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $651 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $568 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 41% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of July 2026, prices for Santiago to San Francisco flights are approximately 5% cheaper when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Fastest flight time

19h 25m

Direct flights

None
The fastest flight from Santiago to San Francisco takes 19h 25m
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
Search flight deals

Frequently asked questions about flying from Santiago to San Francisco

  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5934.4 mi. 19h 25m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $311Free CancellationRating
7.6
1,561 reviews
Search Copa Airlines flights
AviancaPriceFrom $433Free CancellationRating
6.5
2,522 reviews
Search Avianca flights
American AirlinesPriceFrom $481Free CancellationRating
7.1
11,842 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $494Free CancellationRating
7.4
1,966 reviews
Search LATAM Airlines flights
DeltaPriceFrom $509Free CancellationRating
7.8
8,483 reviews
Search Delta flights
United AirlinesPriceFrom $571Free CancellationRating
7.4
10,042 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Fremont
Hayward
Walnut Creek
Bodega Bay
Sonoma
Roseville
Santa Clara
Berkeley
Vallejo
Salinas
Sunnyvale
Burlingame
Daly City
Milpitas
Palo Alto
Big Sur

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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