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Cheap flights from Santiago to San Francisco from $457

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 1/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:55 pm - 12:07 pm
SCL
-
SFO
16h 12m1 stop
Multiple Airlines Logo
5:43 pm - 1:45 pm
SFO
-
SCL
17h 02m2 stops
$528Multiple Airlines
Thu, Mar 26 - Sun, Apr 12
Avianca Logo
4:25 pm - 1:00 pm
SCL
-
SFO
24h 35m2 stops
Avianca Logo
2:30 am - 4:15 am
SFO
-
SCL
22h 45m2 stops
$529Avianca
Tue, Mar 10 - Thu, Jun 4
American Airlines Logo
10:30 pm - 7:12 pm
SCL
-
SFO
25h 42m1 stop
American Airlines Logo
11:35 pm - 8:05 am
SFO
-
SCL
27h 30m1 stop
$533American Airlines
Sat, Feb 7 - Tue, Mar 3
LATAM Airlines Logo
12:20 am - 8:25 pm
SCL
-
SFO
24h 05m2 stops
LATAM Airlines Logo
6:00 am - 5:35 am
SFO
-
SCL
19h 35m1 stop
$534LATAM Airlines
Thu, Mar 12 - Tue, Mar 17
Copa Airlines Logo
1:09 am - 11:40 pm
SCL
-
SFO
26h 31m1 stop
Copa Airlines Logo
1:23 am - 11:26 pm
SFO
-
SCL
19h 03m1 stop
$537Copa Airlines
Thu, Apr 2 - Sun, Apr 19
American Airlines Logo
10:30 pm - 3:05 pm
SCL
-
SFO
21h 35m2 stops
American Airlines Logo
12:08 pm - 8:05 am
SFO
-
SCL
14h 57m1 stop
$538American Airlines
Sat, Feb 7 - Tue, Mar 3
LATAM Airlines Logo
10:10 pm - 3:03 pm
SCL
-
SFO
20h 53m2 stops
LATAM Airlines Logo
6:00 am - 8:15 am
SFO
-
SCL
22h 15m2 stops
$539LATAM Airlines
Mon, Mar 16 - Tue, Mar 31
Delta Logo
11:00 pm - 7:10 pm
SCL
-
SFO
23h 10m2 stops
Delta Logo
12:06 pm - 7:15 am
SFO
-
SCL
16h 09m1 stop
$540Delta
Tue, Apr 7 - Wed, Apr 15
Avianca Logo
7:25 am - 10:50 pm
SCL
-
SFO
19h 25m2 stops
Avianca Logo
12:10 am - 12:30 am
SFO
-
SCL
20h 20m2 stops
$541Avianca
Tue, Mar 10 - Sun, Mar 22
Copa Airlines Logo
4:49 am - 11:40 pm
SCL
-
SFO
21h 51m1 stop
Copa Airlines Logo
1:23 am - 10:43 pm
SFO
-
SCL
18h 20m1 stop
$542Copa Airlines
Mon, Apr 6 - Sun, Apr 12

Delta flights from Santiago to San Francisco

Our best Delta deals on Santiago to San Francisco flight tickets
Delta
Apr 7
SCL11:00 pmSantiago Arturo Merino Benitez
23h 10m
2 stops
SFO7:10 pmSan Francisco
Apr 15
SFO12:06 pmSan Francisco
16h 09m
1 stop
SCL7:15 amSantiago Arturo Merino Benitez
$540
Find similar
Delta
Jan 5
SCL11:10 pmSantiago Arturo Merino Benitez
23h 33m
1 stop
SFO5:43 pmSan Francisco
Mar 8
SFO7:00 amSan Francisco
20h 40m
2 stops
SCL7:40 amSantiago Arturo Merino Benitez
$2,555
Find similar

LATAM Airlines flights from Santiago to San Francisco

Our best LATAM Airlines deals on Santiago to San Francisco flight tickets
LATAM Airlines
Mar 13
SCL10:10 pmSantiago Arturo Merino Benitez
23h 26m
1 stop
SFO5:36 pmSan Francisco
Mar 17
SFO8:55 amSan Francisco
16h 40m
1 stop
SCL5:35 amSantiago Arturo Merino Benitez
$534
Find similar
LATAM Airlines
Mar 16
SCL10:10 pmSantiago Arturo Merino Benitez
20h 53m
2 stops
SFO3:03 pmSan Francisco
Mar 30
SFO8:55 amSan Francisco
19h 20m
2 stops
SCL8:15 amSantiago Arturo Merino Benitez
$539
Find similar
LATAM Airlines
Apr 1
SCL5:30 pmSantiago Arturo Merino Benitez
34h 52m
2 stops
SFO12:22 amSan Francisco
Apr 23
SFO8:55 amSan Francisco
17h 40m
1 stop
SCL5:35 amSantiago Arturo Merino Benitez
$549
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 30, 2025.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 3/26

11:55 pm-12:07 pm

1 stop16h 12m

San Francisco

Sun 4/12

5:43 pm-1:45 pm

2 stops17h 02m

$528

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 3/10

4:25 pm-1:00 pm

2 stops24h 35m

San Francisco

Thu 6/4

2:30 am-4:15 am

2 stops22h 45m

$529

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sat 2/7

10:30 pm-7:12 pm

1 stop25h 42m

San Francisco

Tue 3/3

11:35 pm-8:05 am

1 stop27h 30m

$533

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 3/12

12:20 am-8:25 pm

2 stops24h 05m

San Francisco

Tue 3/17

6:00 am-5:35 am

1 stop19h 35m

$534

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 4/2

1:09 am-11:40 pm

1 stop26h 31m

San Francisco

Sun 4/19

1:23 am-11:26 pm

1 stop19h 03m

$537

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sat 2/7

10:30 pm-3:05 pm

2 stops21h 35m

San Francisco

Tue 3/3

12:08 pm-8:05 am

1 stop14h 57m

$538

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 3/16

10:10 pm-3:03 pm

2 stops20h 53m

San Francisco

Tue 3/31

6:00 am-8:15 am

2 stops22h 15m

$539

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 4/7

11:00 pm-7:10 pm

2 stops23h 10m

San Francisco

Wed 4/15

12:06 pm-7:15 am

1 stop16h 09m

$540

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 3/10

7:25 am-10:50 pm

2 stops19h 25m

San Francisco

Sun 3/22

12:10 am-12:30 am

2 stops20h 20m

$541

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 4/6

4:49 am-11:40 pm

1 stop21h 51m

San Francisco

Sun 4/12

1:23 am-10:43 pm

1 stop18h 20m

$542

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $570.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $655 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $571 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 13% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of December 2025, prices for Santiago to San Francisco flights are approximately 22% cheaper when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Fastest flight time

15h 15m

Direct flights

None
The fastest flight from Santiago to San Francisco takes 15h 15m
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
Search flight deals

  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5935.3 mi. 15h 15m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $408Free CancellationRating
6.6
2,491 reviews
Search Avianca flights
American AirlinesPriceFrom $481Free CancellationRating
7.2
11,073 reviews
Search American Airlines flights
Copa AirlinesPriceFrom $511Free CancellationRating
7.6
1,565 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $518Free CancellationRating
7.5
1,896 reviews
Search LATAM Airlines flights
DeltaPriceFrom $554Free CancellationRating
7.9
8,017 reviews
Search Delta flights
United AirlinesPriceFrom $571Free CancellationRating
7.4
9,121 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Santa Clara
Berkeley
Walnut Creek
Fremont
Daly City
Half Moon Bay
Vallejo
Livermore
Salinas
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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