Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Santiago to San Francisco from $278

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Santiago to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
LATAM Airlines Logo
7:15 am - 11:00 pm
SCL
-
SFO
18h 45m
2 stops
LATAM Airlines Logo
8:00 am - 6:55 am
SFO
-
SCL
19h 55m
2 stops
$519LATAM Airlines
Wed, Apr 8 - Thu, Apr 23
LATAM Airlines Logo
8:40 pm - 11:10 pm
SCL
-
SFO
29h 30m
2 stops
LATAM Airlines Logo
9:30 am - 7:15 am
SFO
-
SCL
18h 45m
2 stops
$520LATAM Airlines
Tue, Apr 21 - Wed, May 27
LATAM Airlines Logo
10:30 am - 3:56 pm
SCL
-
SFO
32h 26m
2 stops
LATAM Airlines Logo
11:59 pm - 1:35 pm
SFO
-
SCL
34h 36m
2 stops
$521LATAM Airlines
Tue, May 19 - Tue, May 26
Avianca Logo
6:40 am - 11:55 pm
SCL
-
SFO
20h 15m
2 stops
Avianca Logo
2:15 pm - 2:15 pm
SFO
-
SCL
21h 00m
2 stops
$522Avianca
Tue, Apr 21 - Mon, May 4
Multiple Airlines Logo
10:25 pm - 12:35 am
SCL
-
SFO
30h 10m
2 stops
Multiple Airlines Logo
10:16 am - 5:35 am
SFO
-
SCL
15h 19m
1 stop
$523Multiple Airlines
Wed, Mar 25 - Wed, Apr 1
Avianca Logo
6:40 am - 11:55 pm
SCL
-
SFO
20h 15m
2 stops
Avianca Logo
11:55 pm - 11:20 pm
SFO
-
SCL
20h 25m
2 stops
$524Avianca
Thu, Apr 16 - Sun, Apr 26
LATAM Airlines Logo
7:15 am - 11:00 pm
SCL
-
SFO
18h 45m
1 stop
LATAM Airlines Logo
12:06 pm - 7:15 am
SFO
-
SCL
16h 09m
1 stop
$525LATAM Airlines
Wed, Apr 8 - Thu, Apr 23
Delta Logo
10:55 pm - 9:23 pm
SCL
-
SFO
25h 28m
1 stop
Delta Logo
7:25 am - 7:15 am
SFO
-
SCL
20h 50m
2 stops
$526Delta
Wed, Apr 22 - Mon, Apr 27
Delta Logo
8:40 pm - 9:23 pm
SCL
-
SFO
27h 43m
2 stops
Delta Logo
11:55 pm - 7:15 am
SFO
-
SCL
28h 20m
2 stops
$527Delta
Tue, Apr 21 - Thu, May 28
LATAM Airlines Logo
8:40 pm - 11:45 am
SCL
-
SFO
18h 05m
1 stop
LATAM Airlines Logo
6:00 am - 7:15 am
SFO
-
SCL
22h 15m
1 stop
$533LATAM Airlines
Mon, Jun 1 - Fri, Jun 12

American Airlines flights from Santiago to San Francisco

Our best American Airlines deals on Santiago to San Francisco flight tickets
American Airlines
Mar 10
SCL9:20 pmSantiago Arturo Merino Benitez
17h 30m
1 stop
SFO10:50 amSan Francisco
Jun 5
SFO12:00 pmSan Francisco
15h 50m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
$669
American Airlines
Mar 10
SCL10:15 pmSantiago Arturo Merino Benitez
20h 50m
1 stop
SFO3:05 pmSan Francisco
Apr 23
SFO1:12 pmSan Francisco
14h 53m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
$702
American Airlines
Mar 10
SCL9:20 pmSantiago Arturo Merino Benitez
21h 45m
2 stops
SFO3:05 pmSan Francisco
Apr 23
SFO1:12 pmSan Francisco
14h 53m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
$706

Delta flights from Santiago to San Francisco

Our best Delta deals on Santiago to San Francisco flight tickets
Delta
Apr 22
SCL10:55 pmSantiago Arturo Merino Benitez
25h 28m
1 stop
SFO9:23 pmSan Francisco
Apr 27
SFO7:25 amSan Francisco
20h 50m
2 stops
SCL7:15 amSantiago Arturo Merino Benitez
$526
Delta
Apr 21
SCL8:40 pmSantiago Arturo Merino Benitez
27h 43m
2 stops
SFO9:23 pmSan Francisco
May 27
SFO8:30 amSan Francisco
19h 45m
1 stop
SCL7:15 amSantiago Arturo Merino Benitez
$527
Delta
May 28
SCL8:40 pmSantiago Arturo Merino Benitez
25h 25m
1 stop
SFO7:05 pmSan Francisco
Aug 20
SFO6:00 amSan Francisco
21h 55m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
$551

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 4/8

7:15 am-11:00 pm

2 stops18h 45m

San Francisco

Thu 4/23

8:00 am-6:55 am

2 stops19h 55m

$519

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 4/21

8:40 pm-11:10 pm

2 stops29h 30m

San Francisco

Wed 5/27

9:30 am-7:15 am

2 stops18h 45m

$520

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 5/19

10:30 am-3:56 pm

2 stops32h 26m

San Francisco

Tue 5/26

11:59 pm-1:35 pm

2 stops34h 36m

$521

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 4/21

6:40 am-11:55 pm

2 stops20h 15m

San Francisco

Mon 5/4

2:15 pm-2:15 pm

2 stops21h 00m

$522

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 3/25

10:25 pm-12:35 am

2 stops30h 10m

San Francisco

Wed 4/1

10:16 am-5:35 am

1 stop15h 19m

$523

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 4/16

6:40 am-11:55 pm

2 stops20h 15m

San Francisco

Sun 4/26

11:55 pm-11:20 pm

2 stops20h 25m

$524

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 4/8

7:15 am-11:00 pm

1 stop18h 45m

San Francisco

Thu 4/23

12:06 pm-7:15 am

1 stop16h 09m

$525

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 4/22

10:55 pm-9:23 pm

1 stop25h 28m

San Francisco

Mon 4/27

7:25 am-7:15 am

2 stops20h 50m

$526

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 4/21

8:40 pm-9:23 pm

2 stops27h 43m

San Francisco

Thu 5/28

11:55 pm-7:15 am

2 stops28h 20m

$527

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 6/1

8:40 pm-11:45 am

1 stop18h 05m

San Francisco

Fri 6/12

6:00 am-7:15 am

1 stop22h 15m

$533

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $570.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $642 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $569 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 3% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of February 2026, prices for Santiago to San Francisco flights are approximately 4% more expensive when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Fastest flight time

16h 36m

Direct flights

None
The fastest flight from Santiago to San Francisco takes 16h 36m
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
Search flight deals

  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5935.3 mi. 16h 36m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $433Free CancellationRating
6.6
2,497 reviews
Search Avianca flights
American AirlinesPriceFrom $481Free CancellationRating
7.2
11,353 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $508Free CancellationRating
7.5
1,919 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $511Free CancellationRating
7.5
1,557 reviews
Search Copa Airlines flights
DeltaPriceFrom $554Free CancellationRating
7.9
8,237 reviews
Search Delta flights
United AirlinesPriceFrom $571Free CancellationRating
7.4
9,347 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Walnut Creek
Hayward
Santa Clara
Big Sur
Berkeley
Calistoga
Fremont
Half Moon Bay
Vallejo
Daly City
Salinas
South San Francisco
Milpitas
Sunnyvale

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 3/28
Sat 4/4
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States