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Cheap flights from Santiago to San Francisco from $279

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 7/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santiago to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
9:30 pm - 1:03 pm
SCL
-
SFO
19h 33m
1 stop
American Airlines Logo
12:12 pm - 7:50 am
SFO
-
SCL
15h 38m
1 stop
$626American Airlines
Wed, Sep 23 - Wed, Oct 14
Avianca Logo
6:40 am - 10:35 pm
SCL
-
SFO
18h 55m
2 stops
Avianca Logo
11:55 pm - 11:20 pm
SFO
-
SCL
20h 25m
2 stops
$627Avianca
Sat, Aug 1 - Sat, Aug 15
Avianca Logo
3:20 pm - 12:50 pm
SCL
-
SFO
24h 30m
2 stops
Avianca Logo
11:55 pm - 2:15 pm
SFO
-
SCL
35h 20m
2 stops
$628Avianca
Fri, Jul 3 - Sat, Jul 18
American Airlines Logo
8:50 pm - 12:49 pm
SCL
-
SFO
18h 59m
2 stops
American Airlines Logo
8:08 am - 8:05 am
SFO
-
SCL
19h 57m
2 stops
$630American Airlines
Tue, Aug 25 - Mon, Sep 7
American Airlines Logo
8:30 pm - 2:27 pm
SCL
-
SFO
20h 57m
2 stops
American Airlines Logo
9:05 am - 6:50 am
SFO
-
SCL
18h 45m
2 stops
$631American Airlines
Wed, Aug 5 - Tue, Aug 11
LATAM Airlines Logo
8:40 pm - 10:20 am
SCL
-
SFO
16h 40m
1 stop
LATAM Airlines Logo
9:30 am - 5:35 am
SFO
-
SCL
17h 05m
1 stop
$633LATAM Airlines
Tue, Jul 7 - Thu, Sep 3
Delta Logo
8:40 pm - 5:15 pm
SCL
-
SFO
23h 35m
1 stop
Delta Logo
11:34 am - 7:15 am
SFO
-
SCL
16h 41m
1 stop
$634Delta
Sun, Aug 16 - Wed, Aug 26
Avianca Logo
12:30 am - 6:25 am
SCL
-
SFO
32h 55m
3 stops
Avianca Logo
7:45 am - 4:45 am
SFO
-
SCL
42h 00m
3 stops
$635Avianca
Tue, Aug 4 - Tue, Aug 18
Avianca Logo
6:40 am - 11:55 pm
SCL
-
SFO
20h 15m
2 stops
Avianca Logo
2:15 pm - 2:15 pm
SFO
-
SCL
21h 00m
2 stops
$637Avianca
Sat, Aug 1 - Sat, Aug 15
Delta Logo
11:00 pm - 7:39 pm
SCL
-
SFO
23h 39m
2 stops
Delta Logo
10:35 pm - 3:25 am
SFO
-
SCL
25h 50m
2 stops
$638Delta
Wed, Aug 5 - Sat, Aug 29

American Airlines flights from Santiago to San Francisco

Our best American Airlines deals on Santiago to San Francisco flight tickets
American Airlines
Sep 23
SCL9:30 pmSantiago Arturo Merino Benitez
19h 33m
1 stop
SFO1:03 pmSan Francisco
Oct 14
SFO12:12 pmSan Francisco
15h 38m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
$626
American Airlines
Aug 25
SCL8:50 pmSantiago Arturo Merino Benitez
18h 59m
2 stops
SFO12:49 pmSan Francisco
Sep 7
SFO8:08 amSan Francisco
19h 57m
2 stops
SCL8:05 amSantiago Arturo Merino Benitez
$630
American Airlines
Aug 5
SCL8:30 pmSantiago Arturo Merino Benitez
20h 57m
2 stops
SFO2:27 pmSan Francisco
Aug 11
SFO9:05 amSan Francisco
18h 45m
2 stops
SCL6:50 amSantiago Arturo Merino Benitez
$631

Avianca flights from Santiago to San Francisco

Our best Avianca deals on Santiago to San Francisco flight tickets
Avianca
May 28
SCL6:40 amSantiago Arturo Merino Benitez
18h 55m
2 stops
SFO10:35 pmSan Francisco
Aug 20
SFO11:55 pmSan Francisco
20h 25m
2 stops
SCL11:20 pmSantiago Arturo Merino Benitez
$624
Avianca
May 28
SCL6:40 amSantiago Arturo Merino Benitez
18h 55m
2 stops
SFO10:35 pmSan Francisco
Aug 20
SFO11:55 pmSan Francisco
20h 25m
2 stops
SCL11:20 pmSantiago Arturo Merino Benitez
$625
Avianca
May 28
SCL6:40 amSantiago Arturo Merino Benitez
20h 15m
2 stops
SFO11:55 pmSan Francisco
Aug 20
SFO2:15 pmSan Francisco
21h 00m
2 stops
SCL2:15 pmSantiago Arturo Merino Benitez
$627

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 25, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 9/23

9:30 pm-1:03 pm

1 stop19h 33m

San Francisco

Wed 10/14

12:12 pm-7:50 am

1 stop15h 38m

$626

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sat 8/1

6:40 am-10:35 pm

2 stops18h 55m

San Francisco

Sat 8/15

11:55 pm-11:20 pm

2 stops20h 25m

$627

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 7/3

3:20 pm-12:50 pm

2 stops24h 30m

San Francisco

Sat 7/18

11:55 pm-2:15 pm

2 stops35h 20m

$628

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 8/25

8:50 pm-12:49 pm

2 stops18h 59m

San Francisco

Mon 9/7

8:08 am-8:05 am

2 stops19h 57m

$630

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 8/5

8:30 pm-2:27 pm

2 stops20h 57m

San Francisco

Tue 8/11

9:05 am-6:50 am

2 stops18h 45m

$631
Quickest round-trip

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 7/7

8:40 pm-10:20 am

1 stop16h 40m

San Francisco

Thu 9/3

9:30 am-5:35 am

1 stop17h 05m

$633

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sun 8/16

8:40 pm-5:15 pm

1 stop23h 35m

San Francisco

Wed 8/26

11:34 am-7:15 am

1 stop16h 41m

$634

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 8/4

12:30 am-6:25 am

3 stops32h 55m

San Francisco

Tue 8/18

7:45 am-4:45 am

3 stops42h 00m

$635

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sat 8/1

6:40 am-11:55 pm

2 stops20h 15m

San Francisco

Sat 8/15

2:15 pm-2:15 pm

2 stops21h 00m

$637

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 8/5

11:00 pm-7:39 pm

2 stops23h 39m

San Francisco

Sat 8/29

10:35 pm-3:25 am

2 stops25h 50m

$638

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santiago and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in February is also cheap. Prices for this month can be found on momondo for an average of $571.

How far in advance should I book a flight from Santiago to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $652 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $599 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 32% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of May 2026, prices for Santiago to San Francisco flights are approximately 6% cheaper when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Fastest flight time

15h 18m

Direct flights

None
The fastest flight from Santiago to San Francisco takes 15h 18m
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
Search flight deals

Frequently asked questions about flying from Santiago to San Francisco

  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5934.4 mi. 15h 18m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $433Free CancellationRating
6.5
2,528 reviews
Search Avianca flights
American AirlinesPriceFrom $481Free CancellationRating
7.1
11,629 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $504Free CancellationRating
7.4
1,920 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $511Free CancellationRating
7.5
1,576 reviews
Search Copa Airlines flights
DeltaPriceFrom $554Free CancellationRating
7.9
8,429 reviews
Search Delta flights
United AirlinesPriceFrom $571Free CancellationRating
7.4
9,749 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Hayward
Roseville
Santa Clara
Berkeley
Fremont
Vallejo
Big Sur
Sunnyvale
Calistoga
South San Francisco
Daly City
Salinas
Pacific Grove
Burlingame

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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