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Cheap flights from Santiago to San Francisco from $297

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 11/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santiago to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
7:25 am - 9:50 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
19h 25m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
1:20 pm - 3:20 pmSFO  San Francisco-SCL Santiago Arturo Merino Benitez
21h 00m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$604Avianca
Sun, Dec 13 - Wed, Jan 13
Avianca Logo
6:40 am - 11:55 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
20h 15m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
2:15 pm - 2:15 pmSFO  San Francisco-SCL Santiago Arturo Merino Benitez
21h 00m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$604Avianca
Thu, Aug 20 - Sat, Aug 29
LATAM Airlines Logo
7:30 am - 9:23 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
18h 53m2 stops Lima J Chavez Intl Los Angeles
LATAM Airlines Logo
7:05 am - 5:35 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
17h 30m1 stop Los Angeles
$633LATAM Airlines
Mon, Nov 16 - Mon, Nov 23
LATAM Airlines Logo
11:55 pm - 1:45 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
18h 50m1 stop Los Angeles
LATAM Airlines Logo
6:00 am - 5:35 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
18h 35m2 stops Atlanta Hartsfield-Jackson Miami
$638LATAM Airlines
Wed, Nov 4 - Wed, Nov 25
Copa Airlines Logo
1:22 am - 5:25 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
21h 03m1 stop Panama City Tocumen Intl
Copa Airlines Logo
7:36 pm - 2:48 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
26h 12m1 stop Panama City Tocumen Intl
$663Copa Airlines
Tue, Nov 3 - Wed, Nov 25
Copa Airlines Logo
5:14 am - 11:40 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
22h 26m1 stop Panama City Tocumen Intl
Copa Airlines Logo
1:31 am - 5:55 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
24h 24m1 stop Panama City Tocumen Intl
$663Copa Airlines
Mon, Sep 28 - Tue, Oct 27
Multiple Airlines Logo
11:55 pm - 10:28 amSCL  Santiago Arturo Merino Benitez-SFO San Francisco
15h 33m1 stop Los Angeles
Multiple Airlines Logo
9:59 am - 5:35 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
14h 36m1 stop Los Angeles
$665Multiple Airlines
Sat, Nov 7 - Sat, Nov 28
Delta Logo
9:50 pm - 10:31 amSCL  Santiago Arturo Merino Benitez-SFO San Francisco
17h 41m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:30 am - 7:40 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
15h 10m1 stop Atlanta Hartsfield-Jackson
$666Delta
Sun, Dec 13 - Wed, Jan 13
Delta Logo
11:55 pm - 7:58 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
24h 03m1 stop New York John F Kennedy Intl
Delta Logo
6:00 am - 5:35 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
19h 35m2 stops Atlanta Hartsfield-Jackson Miami
$666Delta
Mon, Sep 21 - Mon, Oct 5
Multiple Airlines Logo
11:55 pm - 2:22 pmSCL  Santiago Arturo Merino Benitez-SFO San Francisco
18h 27m1 stop Los Angeles
Multiple Airlines Logo
7:27 am - 5:35 amSFO  San Francisco-SCL Santiago Arturo Merino Benitez
18h 08m1 stop Los Angeles
$681Multiple Airlines
Thu, Oct 8 - Mon, Oct 12

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Avianca flights from Santiago to San Francisco

Our best Avianca deals on Santiago to San Francisco flight tickets
Avianca
Aug 25
SCL6:40 amSantiago Arturo Merino Benitez
18h 55m
2 stops
SFO10:35 pmSan Francisco
Sep 7
SFO11:55 pmSan Francisco
20h 25m
2 stops
SCL12:20 amSantiago Arturo Merino Benitez
$604
Avianca
Jan 29
SCL7:25 amSantiago Arturo Merino Benitez
19h 25m
2 stops
SFO9:50 pmSan Francisco
Feb 19
SFO1:20 pmSan Francisco
21h 00m
2 stops
SCL3:20 pmSantiago Arturo Merino Benitez
$606
Avianca
Sep 14
SCL7:40 amSantiago Arturo Merino Benitez
18h 55m
2 stops
SFO10:35 pmSan Francisco
Sep 20
SFO2:15 pmSan Francisco
21h 00m
2 stops
SCL3:15 pmSantiago Arturo Merino Benitez
$608

LATAM Airlines flights from Santiago to San Francisco

Our best LATAM Airlines deals on Santiago to San Francisco flight tickets
LATAM Airlines
Nov 16
SCL7:30 amSantiago Arturo Merino Benitez
18h 53m
2 stops
SFO9:23 pmSan Francisco
Nov 23
SFO7:05 amSan Francisco
17h 30m
1 stop
SCL5:35 amSantiago Arturo Merino Benitez
$633
LATAM Airlines
Dec 10
SCL9:55 pmSantiago Arturo Merino Benitez
18h 06m
2 stops
SFO11:01 amSan Francisco
Jan 21
SFO6:00 amSan Francisco
19h 40m
1 stop
SCL6:40 amSantiago Arturo Merino Benitez
$652
LATAM Airlines
Oct 1
SCL11:55 pmSantiago Arturo Merino Benitez
19h 59m
1 stop
SFO3:54 pmSan Francisco
Oct 31
SFO8:00 amSan Francisco
19h 40m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
$661

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Sun 12/13

7:25 am-9:50 pm

2 stops19h 25m

San Francisco

Wed 1/13

1:20 pm-3:20 pm

2 stops21h 00m

$604

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Thu 8/20

6:40 am-11:55 pm

2 stops20h 15m

San Francisco

Sat 8/29

2:15 pm-2:15 pm

2 stops21h 00m

$604

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Mon 11/16

7:30 am-9:23 pm

2 stops18h 53m

San Francisco

Mon 11/23

7:05 am-5:35 am

1 stop17h 30m

$633

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Wed 11/4

11:55 pm-1:45 pm

1 stop18h 50m

San Francisco

Wed 11/25

6:00 am-5:35 am

2 stops18h 35m

$638

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Tue 11/3

1:22 am-5:25 pm

1 stop21h 03m

San Francisco

Wed 11/25

7:36 pm-2:48 am

1 stop26h 12m

$663

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Mon 9/28

5:14 am-11:40 pm

1 stop22h 26m

San Francisco

Tue 10/27

1:31 am-5:55 am

1 stop24h 24m

$663
Quickest round-trip

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Sat 11/7

11:55 pm-10:28 am

1 stop15h 33m

San Francisco

Sat 11/28

9:59 am-5:35 am

1 stop14h 36m

$665

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Sun 12/13

9:50 pm-10:31 am

1 stop17h 41m

San Francisco

Wed 1/13

11:30 am-7:40 am

1 stop15h 10m

$666

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Mon 9/21

11:55 pm-7:58 pm

1 stop24h 03m

San Francisco

Mon 10/5

6:00 am-5:35 am

2 stops19h 35m

$666

SantiagoSan Francisco

SCL Santiago Arturo Merino Benitez - SFO San Francisco

SCLSFO

Santiago Arturo Merino Benitez

Thu 10/8

11:55 pm-2:22 pm

1 stop18h 27m

San Francisco

Mon 10/12

7:27 am-5:35 am

1 stop18h 08m

$681

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santiago and San Francisco?

Prices are currently typical for flights on this route.

Typical prices usually range from $577 to $787.
The lowest price recently found on this route was $604.

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in November is also cheap. Prices for this month can be found on momondo for an average of $557.

How far in advance should I book a flight from Santiago to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $651 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $568 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 41% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of August 2026, prices for Santiago to San Francisco flights are approximately 2% more expensive when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Fastest flight time

17h 18m

Direct flights

None
The fastest flight from Santiago to San Francisco takes 17h 18m
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
Search flight deals

Frequently asked questions about flying from Santiago to San Francisco

  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5934.4 mi. 17h 18m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $311Free CancellationRating
7.6
1,565 reviews
Search Copa Airlines flights
AviancaPriceFrom $433Free CancellationRating
6.5
2,523 reviews
Search Avianca flights
American AirlinesPriceFrom $481Free CancellationRating
7.1
11,862 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $501Free CancellationRating
7.4
1,973 reviews
Search LATAM Airlines flights
DeltaPriceFrom $509Free CancellationRating
7.8
8,492 reviews
Search Delta flights
United AirlinesPriceFrom $571Free CancellationRating
7.4
10,072 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Fremont
Berkeley
Hayward
Walnut Creek
Bodega Bay
Roseville
Sonoma
Santa Clara
Vallejo
Salinas
Sunnyvale
Milpitas
Daly City
Burlingame
Turlock
Marina

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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