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Cheap flights from Santiago to San Francisco from $457

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 4/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santiago to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
10:45 pm - 5:54 pm
SCL
-
SFO
24h 09m
1 stop
United Airlines Logo
11:59 pm - 8:50 am
SFO
-
SCL
27h 51m
1 stop
$528United Airlines
Fri, Feb 13 - Sun, Mar 1
United Airlines Logo
10:45 pm - 11:59 pm
SCL
-
SFO
30h 14m
1 stop
United Airlines Logo
11:59 pm - 8:50 am
SFO
-
SCL
27h 51m
1 stop
$530United Airlines
Wed, Feb 4 - Mon, Feb 16
United Airlines Logo
10:45 pm - 5:54 pm
SCL
-
SFO
24h 09m
1 stop
United Airlines Logo
12:43 am - 8:50 am
SFO
-
SCL
27h 07m
1 stop
$531United Airlines
Fri, Feb 13 - Sun, Mar 1
LATAM Airlines Logo
11:10 pm - 12:55 pm
SCL
-
SFO
18h 45m
1 stop
LATAM Airlines Logo
6:00 am - 7:40 am
SFO
-
SCL
20h 40m
2 stops
$532LATAM Airlines
Tue, Feb 10 - Tue, Feb 17
LATAM Airlines Logo
10:10 pm - 7:19 pm
SCL
-
SFO
25h 09m
1 stop
LATAM Airlines Logo
9:25 am - 7:50 am
SFO
-
SCL
18h 25m
1 stop
$533LATAM Airlines
Wed, Mar 18 - Tue, Mar 31
LATAM Airlines Logo
11:10 pm - 7:56 pm
SCL
-
SFO
25h 46m
1 stop
LATAM Airlines Logo
7:00 am - 6:55 am
SFO
-
SCL
18h 55m
1 stop
$535LATAM Airlines
Fri, Feb 13 - Thu, Feb 26
American Airlines Logo
10:35 pm - 11:02 am
SCL
-
SFO
17h 27m
1 stop
American Airlines Logo
7:00 am - 8:15 am
SFO
-
SCL
20h 15m
1 stop
$537American Airlines
Mon, Jan 26 - Wed, Feb 4
American Airlines Logo
10:35 pm - 1:46 pm
SCL
-
SFO
20h 11m
2 stops
American Airlines Logo
10:11 am - 8:15 am
SFO
-
SCL
17h 04m
1 stop
$540American Airlines
Thu, Jan 29 - Wed, Feb 4
American Airlines Logo
10:35 pm - 11:02 am
SCL
-
SFO
17h 27m
1 stop
American Airlines Logo
7:00 am - 8:15 am
SFO
-
SCL
20h 15m
2 stops
$542American Airlines
Mon, Jan 26 - Wed, Feb 4
Copa Airlines Logo
5:17 am - 11:40 pm
SCL
-
SFO
22h 23m
1 stop
Copa Airlines Logo
1:23 am - 7:23 pm
SFO
-
SCL
15h 00m
1 stop
$543Copa Airlines
Thu, Apr 2 - Thu, Apr 16

Copa Airlines flights from Santiago to San Francisco

Our best Copa Airlines deals on Santiago to San Francisco flight tickets
Copa Airlines
Apr 2
SCL5:17 amSantiago Arturo Merino Benitez
22h 23m
1 stop
SFO11:40 pmSan Francisco
Apr 16
SFO1:23 amSan Francisco
15h 00m
1 stop
SCL7:23 pmSantiago Arturo Merino Benitez
$543
Copa Airlines
Apr 6
SCL4:17 amSantiago Arturo Merino Benitez
22h 23m
1 stop
SFO11:40 pmSan Francisco
Apr 12
SFO1:23 amSan Francisco
18h 20m
1 stop
SCL10:43 pmSantiago Arturo Merino Benitez
$558
Copa Airlines
Apr 1
SCL12:25 pmSantiago Arturo Merino Benitez
15h 15m
1 stop
SFO11:40 pmSan Francisco
Apr 22
SFO1:23 amSan Francisco
24h 40m
1 stop
SCL5:03 amSantiago Arturo Merino Benitez
$578

LATAM Airlines flights from Santiago to San Francisco

Our best LATAM Airlines deals on Santiago to San Francisco flight tickets
LATAM Airlines
Feb 10
SCL11:10 pmSantiago Arturo Merino Benitez
18h 45m
1 stop
SFO12:55 pmSan Francisco
Feb 17
SFO6:00 amSan Francisco
20h 40m
2 stops
SCL7:40 amSantiago Arturo Merino Benitez
$532
LATAM Airlines
Mar 18
SCL10:10 pmSantiago Arturo Merino Benitez
25h 09m
1 stop
SFO7:19 pmSan Francisco
Mar 31
SFO9:25 amSan Francisco
18h 25m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
$533
LATAM Airlines
Feb 13
SCL11:10 pmSantiago Arturo Merino Benitez
25h 46m
1 stop
SFO7:56 pmSan Francisco
Feb 26
SFO7:00 amSan Francisco
18h 55m
1 stop
SCL6:55 amSantiago Arturo Merino Benitez
$535

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 2/13

10:45 pm-5:54 pm

1 stop24h 09m

San Francisco

Sun 3/1

11:59 pm-8:50 am

1 stop27h 51m

$528

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 2/4

10:45 pm-11:59 pm

1 stop30h 14m

San Francisco

Mon 2/16

11:59 pm-8:50 am

1 stop27h 51m

$530

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 2/13

10:45 pm-5:54 pm

1 stop24h 09m

San Francisco

Sun 3/1

12:43 am-8:50 am

1 stop27h 07m

$531

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 2/10

11:10 pm-12:55 pm

1 stop18h 45m

San Francisco

Tue 2/17

6:00 am-7:40 am

2 stops20h 40m

$532

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 3/18

10:10 pm-7:19 pm

1 stop25h 09m

San Francisco

Tue 3/31

9:25 am-7:50 am

1 stop18h 25m

$533

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 2/13

11:10 pm-7:56 pm

1 stop25h 46m

San Francisco

Thu 2/26

7:00 am-6:55 am

1 stop18h 55m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 1/26

10:35 pm-11:02 am

1 stop17h 27m

San Francisco

Wed 2/4

7:00 am-8:15 am

1 stop20h 15m

$537

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 1/29

10:35 pm-1:46 pm

2 stops20h 11m

San Francisco

Wed 2/4

10:11 am-8:15 am

1 stop17h 04m

$540

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 1/26

10:35 pm-11:02 am

1 stop17h 27m

San Francisco

Wed 2/4

7:00 am-8:15 am

2 stops20h 15m

$542

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 4/2

5:17 am-11:40 pm

1 stop22h 23m

San Francisco

Thu 4/16

1:23 am-7:23 pm

1 stop15h 00m

$543

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $570.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $652 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $575 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 13% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of January 2026, prices for Santiago to San Francisco flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Fastest flight time

15h 23m

Direct flights

None
The fastest flight from Santiago to San Francisco takes 15h 23m
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
Search flight deals

  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5935.3 mi. 15h 23m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $408Free CancellationRating
6.6
2,492 reviews
Search Avianca flights
American AirlinesPriceFrom $481Free CancellationRating
7.2
11,129 reviews
Search American Airlines flights
Copa AirlinesPriceFrom $511Free CancellationRating
7.6
1,559 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $518Free CancellationRating
7.5
1,904 reviews
Search LATAM Airlines flights
DeltaPriceFrom $551Free CancellationRating
7.9
8,048 reviews
Search Delta flights
United AirlinesPriceFrom $571Free CancellationRating
7.4
9,163 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Santa Clara
Berkeley
Walnut Creek
Fremont
Half Moon Bay
Daly City
Vallejo
Livermore
Salinas
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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