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Cheap flights from Santiago to San Francisco from $288

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 2/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
11:10 pm - 12:50 pm
SCL
-
SFO
18h 40m1 stop
Delta Logo
7:00 am - 7:40 am
SFO
-
SCL
19h 40m2 stops
$525Delta
Wed, Feb 25 - Wed, Mar 4
LATAM Airlines Logo
6:30 pm - 12:55 pm
SCL
-
SFO
23h 25m2 stops
LATAM Airlines Logo
6:00 am - 4:30 am
SFO
-
SCL
17h 30m2 stops
$532LATAM Airlines
Tue, Jan 27 - Tue, Feb 24
LATAM Airlines Logo
7:15 am - 11:12 pm
SCL
-
SFO
18h 57m2 stops
LATAM Airlines Logo
7:30 am - 5:35 am
SFO
-
SCL
19h 05m2 stops
$535LATAM Airlines
Wed, Apr 15 - Wed, May 6
LATAM Airlines Logo
9:30 pm - 12:55 pm
SCL
-
SFO
20h 25m1 stop
LATAM Airlines Logo
6:00 am - 7:40 am
SFO
-
SCL
20h 40m2 stops
$537LATAM Airlines
Thu, Jan 29 - Tue, Mar 3
American Airlines Logo
10:30 pm - 7:12 pm
SCL
-
SFO
25h 42m1 stop
American Airlines Logo
12:17 am - 8:15 am
SFO
-
SCL
26h 58m1 stop
$542American Airlines
Wed, Jan 21 - Wed, Jan 28
American Airlines Logo
10:30 pm - 9:17 am
SCL
-
SFO
15h 47m1 stop
American Airlines Logo
6:00 am - 7:55 am
SFO
-
SCL
20h 55m1 stop
$544American Airlines
Thu, Jan 29 - Tue, Mar 3
American Airlines Logo
10:30 pm - 12:40 pm
SCL
-
SFO
19h 10m2 stops
American Airlines Logo
10:11 am - 7:50 am
SFO
-
SCL
16h 39m2 stops
$547American Airlines
Wed, Jan 21 - Wed, Jan 28
Avianca Logo
4:25 pm - 11:20 pm
SCL
-
SFO
35h 55m2 stops
Avianca Logo
1:20 pm - 12:30 am
SFO
-
SCL
30h 10m2 stops
$548Avianca
Wed, Jan 21 - Thu, Jan 29
American Airlines Logo
10:30 pm - 9:37 pm
SCL
-
SFO
28h 07m1 stop
American Airlines Logo
10:06 am - 9:25 am
SFO
-
SCL
18h 19m2 stops
$549American Airlines
Thu, Jan 29 - Tue, Mar 3
Avianca Logo
6:10 am - 11:55 pm
SCL
-
SFO
20h 45m2 stops
Avianca Logo
12:05 am - 10:30 pm
SFO
-
SCL
19h 25m2 stops
$550Avianca
Tue, Apr 21 - Sun, May 3

Delta flights from Santiago to San Francisco

Our best Delta deals on Santiago to San Francisco flight tickets
Delta
Feb 25
SCL11:10 pmSantiago Arturo Merino Benitez
18h 40m
1 stop
SFO12:50 pmSan Francisco
Mar 4
SFO7:00 amSan Francisco
19h 40m
2 stops
SCL7:40 amSantiago Arturo Merino Benitez
$525
Find similar
Delta
Apr 29
SCL11:25 pmSantiago Arturo Merino Benitez
26h 24m
2 stops
SFO10:49 pmSan Francisco
May 13
SFO6:00 amSan Francisco
22h 00m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
$553
Find similar
Delta
Apr 6
SCL11:00 pmSantiago Arturo Merino Benitez
23h 20m
2 stops
SFO7:20 pmSan Francisco
Apr 13
SFO6:00 amSan Francisco
21h 55m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
$555
Find similar

American Airlines flights from Santiago to San Francisco

Our best American Airlines deals on Santiago to San Francisco flight tickets
American Airlines
Jan 21
SCL10:30 pmSantiago Arturo Merino Benitez
25h 42m
1 stop
SFO7:12 pmSan Francisco
Jan 28
SFO12:17 amSan Francisco
26h 58m
1 stop
SCL8:15 amSantiago Arturo Merino Benitez
$542
Find similar
American Airlines
Jan 29
SCL10:30 pmSantiago Arturo Merino Benitez
15h 47m
1 stop
SFO9:17 amSan Francisco
Mar 3
SFO6:00 amSan Francisco
20h 55m
1 stop
SCL7:55 amSantiago Arturo Merino Benitez
$544
Find similar
American Airlines
Jan 21
SCL10:30 pmSantiago Arturo Merino Benitez
28h 07m
1 stop
SFO9:37 pmSan Francisco
Jan 29
SFO7:00 amSan Francisco
20h 15m
2 stops
SCL8:15 amSantiago Arturo Merino Benitez
$547
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 8, 2025.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 2/25

11:10 pm-12:50 pm

1 stop18h 40m

San Francisco

Wed 3/4

7:00 am-7:40 am

2 stops19h 40m

$525

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 1/27

6:30 pm-12:55 pm

2 stops23h 25m

San Francisco

Tue 2/24

6:00 am-4:30 am

2 stops17h 30m

$532

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 4/15

7:15 am-11:12 pm

2 stops18h 57m

San Francisco

Wed 5/6

7:30 am-5:35 am

2 stops19h 05m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 1/29

9:30 pm-12:55 pm

1 stop20h 25m

San Francisco

Tue 3/3

6:00 am-7:40 am

2 stops20h 40m

$537

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 1/21

10:30 pm-7:12 pm

1 stop25h 42m

San Francisco

Wed 1/28

12:17 am-8:15 am

1 stop26h 58m

$542

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 1/29

10:30 pm-9:17 am

1 stop15h 47m

San Francisco

Tue 3/3

6:00 am-7:55 am

1 stop20h 55m

$544

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 1/21

10:30 pm-12:40 pm

2 stops19h 10m

San Francisco

Wed 1/28

10:11 am-7:50 am

2 stops16h 39m

$547

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 1/21

4:25 pm-11:20 pm

2 stops35h 55m

San Francisco

Thu 1/29

1:20 pm-12:30 am

2 stops30h 10m

$548

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 1/29

10:30 pm-9:37 pm

1 stop28h 07m

San Francisco

Tue 3/3

10:06 am-9:25 am

2 stops18h 19m

$549

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 4/21

6:10 am-11:55 pm

2 stops20h 45m

San Francisco

Sun 5/3

12:05 am-10:30 pm

2 stops19h 25m

$550

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $570.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Santiago to San Francisco is on a Saturday when prices can be found for as low as $663. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $834.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Santiago to San Francisco flights are usually those with departure times in the afternoon. Our users have found flights to San Francisco in the afternoon for as low as $565. Flights in the evening are often more expensive with an average ticket price of $822.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $661 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $571 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 29% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of December 2025, prices for Santiago to San Francisco flights are approximately 22% cheaper when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Fastest flight time

16h 09m

Direct flights

None
The fastest flight from Santiago to San Francisco takes 16h 09m
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
Search flight deals

  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5935.3 mi. 15h 15m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $319Free CancellationRating
7.6
1,555 reviews
Search Copa Airlines flights
AviancaPriceFrom $408Free CancellationRating
6.6
2,476 reviews
Search Avianca flights
American AirlinesPriceFrom $481Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $508Free CancellationRating
7.5
1,889 reviews
Search LATAM Airlines flights
DeltaPriceFrom $553Free CancellationRating
7.9
8,011 reviews
Search Delta flights
United AirlinesPriceFrom $571Free CancellationRating
7.4
9,084 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Big Sur
Calistoga
Santa Clara
Walnut Creek
Berkeley
Daly City
Fremont
Half Moon Bay
Vallejo
Salinas
Livermore
Turlock
Sunnyvale

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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