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Cheap flights from Santiago to San Francisco from $278

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to San Francisco departing on 2/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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LATAM Airlines Logo
8:30 am - 3:21 pm
SCL
-
SFO
33h 51m
3 stops
LATAM Airlines Logo
6:00 am - 7:15 am
SFO
-
SCL
22h 15m
2 stops
$522LATAM Airlines
Mon, Apr 27 - Sun, May 3
LATAM Airlines Logo
10:30 am - 1:36 pm
SCL
-
SFO
30h 06m
2 stops
LATAM Airlines Logo
7:00 am - 5:35 am
SFO
-
SCL
19h 35m
1 stop
$523LATAM Airlines
Sun, May 17 - Sun, Jun 14
Avianca Logo
6:40 am - 11:55 pm
SCL
-
SFO
20h 15m
2 stops
Avianca Logo
2:15 pm - 2:15 pm
SFO
-
SCL
21h 00m
2 stops
$527Avianca
Tue, Apr 21 - Mon, May 4
LATAM Airlines Logo
8:40 pm - 7:19 pm
SCL
-
SFO
26h 39m
1 stop
LATAM Airlines Logo
11:39 pm - 1:35 pm
SFO
-
SCL
34h 56m
2 stops
$535LATAM Airlines
Wed, Apr 1 - Thu, Apr 23
LATAM Airlines Logo
5:30 pm - 7:19 pm
SCL
-
SFO
29h 49m
2 stops
LATAM Airlines Logo
10:55 pm - 6:50 am
SFO
-
SCL
28h 55m
1 stop
$538LATAM Airlines
Wed, Apr 1 - Thu, Apr 30
LATAM Airlines Logo
11:05 pm - 7:09 pm
SCL
-
SFO
23h 04m
2 stops
LATAM Airlines Logo
8:00 am - 2:05 pm
SFO
-
SCL
27h 05m
2 stops
$539LATAM Airlines
Wed, Apr 22 - Mon, Apr 27
LATAM Airlines Logo
8:40 pm - 3:21 pm
SCL
-
SFO
21h 41m
2 stops
LATAM Airlines Logo
9:30 am - 7:15 am
SFO
-
SCL
18h 45m
2 stops
$540LATAM Airlines
Sun, May 3 - Wed, May 27
Avianca Logo
6:40 am - 11:55 pm
SCL
-
SFO
20h 15m
2 stops
Avianca Logo
2:15 pm - 2:15 pm
SFO
-
SCL
21h 00m
2 stops
$542Avianca
Thu, May 28 - Thu, Aug 20
LATAM Airlines Logo
11:00 pm - 7:19 pm
SCL
-
SFO
23h 19m
2 stops
LATAM Airlines Logo
12:06 pm - 7:15 am
SFO
-
SCL
16h 09m
1 stop
$544LATAM Airlines
Mon, Apr 6 - Mon, Apr 13
American Airlines Logo
8:35 pm - 8:54 pm
SCL
-
SFO
27h 19m
1 stop
American Airlines Logo
6:15 am - 7:05 am
SFO
-
SCL
21h 50m
1 stop
$547American Airlines
Wed, Apr 15 - Wed, May 6

LATAM Airlines flights from Santiago to San Francisco

Our best LATAM Airlines deals on Santiago to San Francisco flight tickets
LATAM Airlines
Apr 27
SCL8:30 amSantiago Arturo Merino Benitez
33h 51m
3 stops
SFO3:21 pmSan Francisco
May 3
SFO6:00 amSan Francisco
22h 15m
2 stops
SCL7:15 amSantiago Arturo Merino Benitez
$522
LATAM Airlines
May 17
SCL10:30 amSantiago Arturo Merino Benitez
30h 06m
2 stops
SFO1:36 pmSan Francisco
Jun 14
SFO7:00 amSan Francisco
19h 35m
1 stop
SCL5:35 amSantiago Arturo Merino Benitez
$523
LATAM Airlines
Apr 1
SCL8:40 pmSantiago Arturo Merino Benitez
26h 39m
1 stop
SFO7:19 pmSan Francisco
Apr 23
SFO11:39 pmSan Francisco
34h 56m
2 stops
SCL1:35 pmSantiago Arturo Merino Benitez
$535

Delta flights from Santiago to San Francisco

Our best Delta deals on Santiago to San Francisco flight tickets
Delta
May 28
SCL8:40 pmSantiago Arturo Merino Benitez
21h 13m
1 stop
SFO2:53 pmSan Francisco
Aug 20
SFO6:00 amSan Francisco
22h 15m
1 stop
SCL7:15 amSantiago Arturo Merino Benitez
$551
Delta
Aug 5
SCL11:25 pmSantiago Arturo Merino Benitez
18h 46m
1 stop
SFO3:11 pmSan Francisco
Aug 20
SFO8:55 amSan Francisco
17h 40m
1 stop
SCL5:35 amSantiago Arturo Merino Benitez
$596
Delta
Feb 16
SCL11:10 pmSantiago Arturo Merino Benitez
25h 46m
1 stop
SFO7:56 pmSan Francisco
Feb 21
SFO11:47 amSan Francisco
14h 53m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
$1,120

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 4/27

8:30 am-3:21 pm

3 stops33h 51m

San Francisco

Sun 5/3

6:00 am-7:15 am

2 stops22h 15m

$522

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sun 5/17

10:30 am-1:36 pm

2 stops30h 06m

San Francisco

Sun 6/14

7:00 am-5:35 am

1 stop19h 35m

$523

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 4/21

6:40 am-11:55 pm

2 stops20h 15m

San Francisco

Mon 5/4

2:15 pm-2:15 pm

2 stops21h 00m

$527

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 4/1

8:40 pm-7:19 pm

1 stop26h 39m

San Francisco

Thu 4/23

11:39 pm-1:35 pm

2 stops34h 56m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 4/1

5:30 pm-7:19 pm

2 stops29h 49m

San Francisco

Thu 4/30

10:55 pm-6:50 am

1 stop28h 55m

$538

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 4/22

11:05 pm-7:09 pm

2 stops23h 04m

San Francisco

Mon 4/27

8:00 am-2:05 pm

2 stops27h 05m

$539

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sun 5/3

8:40 pm-3:21 pm

2 stops21h 41m

San Francisco

Wed 5/27

9:30 am-7:15 am

2 stops18h 45m

$540

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 5/28

6:40 am-11:55 pm

2 stops20h 15m

San Francisco

Thu 8/20

2:15 pm-2:15 pm

2 stops21h 00m

$542

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 4/6

11:00 pm-7:19 pm

2 stops23h 19m

San Francisco

Mon 4/13

12:06 pm-7:15 am

1 stop16h 09m

$544

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 4/15

8:35 pm-8:54 pm

1 stop27h 19m

San Francisco

Wed 5/6

6:15 am-7:05 am

1 stop21h 50m

$547

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Santiago to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $570.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $641 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Santiago for as low as $561 on momondo.

Can stopping save me money on Santiago to San Francisco flights?

You could potentially save up to 29% on your flight if you consider stops on a Santiago to San Francisco flight.

How have Santiago to San Francisco flight prices changed over time?

As of February 2026, prices for Santiago to San Francisco flights are approximately 11% more expensive when compared to flights at the same time last year.

When to book flights from Santiago to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to San Francisco (SCL to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to San Francisco

Fastest flight time

17h 10m

Direct flights

None
The fastest flight from Santiago to San Francisco takes 17h 10m
There are no direct flights from Santiago to San Francisco. There are no popular flight routes from Santiago to San Francisco.
Search flight deals

  • How far is Santiago Arturo Merino Benitez to San Francisco by plane?

    A flight from Santiago Arturo Merino Benitez to San Francisco will travel around 5935.3 mi. 17h 10m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport refresh daily.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to San Francisco Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santiago to San Francisco?

Best airlines flying from Santiago to San Francisco

Compare and see reviews for airlines that fly from Santiago to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $433Free CancellationRating
6.6
2,497 reviews
Search Avianca flights
American AirlinesPriceFrom $481Free CancellationRating
7.2
11,266 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $508Free CancellationRating
7.5
1,920 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $511Free CancellationRating
7.5
1,557 reviews
Search Copa Airlines flights
DeltaPriceFrom $554Free CancellationRating
7.9
8,180 reviews
Search Delta flights
United AirlinesPriceFrom $571Free CancellationRating
7.4
9,273 reviews
Search United Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Walnut Creek
Santa Clara
Calistoga
Berkeley
Big Sur
Fremont
Daly City
Half Moon Bay
Salinas
Vallejo
Sunnyvale
Milpitas
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to San Francisco with flexible booking policies on momondo?

All flight searches from Santiago to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santiago to San Francisco?

Once you have performed a search for Santiago to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Santiago to San Francisco right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santiago to San Francisco flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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