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Cheap flights from Panama to San Diego from $285

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama to San Diego departing on 9/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Panama to San Diego

Recent round-trip flight deals from Panama to San Diego

Copa Airlines Logo
1:15 pm - 5:57 pmPTY-SAN
6h 42mnonstop
Copa Airlines Logo
9:07 pm - 5:20 amSAN-PTY
6h 13mnonstop
$406Copa Airlines
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Mon, Oct 20 - Fri, Oct 31
United Airlines Logo
10:00 am - 9:45 pmPTY-SAN
13h 45m1 stop
United Airlines Logo
7:50 pm - 6:49 pmSAN-PTY
20h 59m1 stop
$412United Airlines
Find Deal
Tue, Oct 21 - Sat, Nov 1
United Airlines Logo
3:30 pm - 9:12 amPTY-SAN
19h 42m2 stops
United Airlines Logo
8:00 am - 6:37 pmSAN-PTY
8h 37m1 stop
$430United Airlines
Find Deal
Wed, Oct 1 - Wed, Oct 8
American Airlines Logo
3:15 pm - 10:56 amPTY-SAN
21h 41m2 stops
American Airlines Logo
2:55 pm - 1:36 pmSAN-PTY
19h 41m2 stops
$432American Airlines
Find Deal
Fri, Oct 31 - Tue, Nov 18
United Airlines Logo
3:35 pm - 12:15 amPTY-SAN
10h 40m1 stop
United Airlines Logo
8:00 am - 6:37 pmSAN-PTY
8h 37m1 stop
$439United Airlines
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Thu, Oct 9 - Sun, Oct 12
Copa Airlines Logo
1:15 pm - 5:50 pmPTY-SAN
6h 35mnonstop
Copa Airlines Logo
9:08 pm - 5:25 amSAN-PTY
6h 17mnonstop
$441Copa Airlines
Find Deal
Sun, Sep 21 - Wed, Sep 24
United Airlines Logo
3:30 pm - 10:27 amPTY-SAN
20h 57m2 stops
United Airlines Logo
4:44 pm - 2:14 pmSAN-PTY
19h 30m1 stop
$443United Airlines
Find Deal
Thu, Oct 9 - Sun, Oct 12
Delta Logo
2:10 pm - 11:24 pmPTY-SAN
11h 14m1 stop
Delta Logo
10:30 pm - 12:55 pmSAN-PTY
12h 25m1 stop
$447Delta
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Thu, Sep 25 - Sun, Sep 28
United Airlines Logo
10:00 am - 11:41 pmPTY-SAN
15h 41m2 stops
United Airlines Logo
7:50 pm - 1:45 pmSAN-PTY
15h 55m2 stops
$450United Airlines
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Thu, Oct 23 - Tue, Oct 28
American Airlines Logo
3:15 pm - 11:30 amPTY-SAN
22h 15m1 stop
American Airlines Logo
10:45 pm - 2:03 pmSAN-PTY
13h 18m1 stop
$515American Airlines
Find Deal
Sat, Oct 18 - Wed, Oct 29

United Airlines flights from Panama to San Diego

Our best United Airlines deals on Panama to San Diego flight tickets
United Airlines
Oct 21
PTY10:00 amPanama City Tocumen Intl
13h 45m
1 stop
SAN9:45 pmSan Diego
Nov 1
SAN7:50 pmSan Diego
20h 59m
1 stop
PTY6:49 pmPanama City Tocumen Intl
$412
Find similar
United Airlines
Oct 1
PTY3:30 pmPanama City Tocumen Intl
19h 42m
2 stops
SAN9:12 amSan Diego
Oct 8
SAN8:00 amSan Diego
8h 37m
1 stop
PTY6:37 pmPanama City Tocumen Intl
$430
Find similar
United Airlines
Oct 9
PTY3:35 pmPanama City Tocumen Intl
10h 40m
1 stop
SAN12:15 amSan Diego
Oct 12
SAN8:00 amSan Diego
8h 37m
1 stop
PTY6:37 pmPanama City Tocumen Intl
$439
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Copa Airlines flights from Panama to San Diego

Our best Copa Airlines deals on Panama to San Diego flight tickets
Copa Airlines
Oct 20
PTY1:15 pmPanama City Tocumen Intl
6h 42m
SAN5:57 pmSan Diego
Oct 31
SAN9:07 pmSan Diego
6h 13m
PTY5:20 amPanama City Tocumen Intl
$406
Find similar
Copa Airlines
Sep 21
PTY1:15 pmPanama City Tocumen Intl
6h 35m
SAN5:50 pmSan Diego
Sep 24
SAN9:08 pmSan Diego
6h 17m
PTY5:25 amPanama City Tocumen Intl
$441
Find similar
Copa Airlines
Dec 14
PTY1:15 pmPanama City Tocumen Intl
6h 52m
SAN5:07 pmSan Diego
Jan 2
SAN8:16 pmSan Diego
6h 04m
PTY5:20 amPanama City Tocumen Intl
$642
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Panama to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 10/20

1:15 pm-5:57 pm

Nonstop6h 42m

San Diego

Fri 10/31

9:07 pm-5:20 am

Nonstop6h 13m

$406

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Tue 10/21

10:00 am-9:45 pm

1 stop13h 45m

San Diego

Sat 11/1

7:50 pm-6:49 pm

1 stop20h 59m

$412

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 10/1

3:30 pm-9:12 am

2 stops19h 42m

San Diego

Wed 10/8

8:00 am-6:37 pm

1 stop8h 37m

$430

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 10/31

3:15 pm-10:56 am

2 stops21h 41m

San Diego

Tue 11/18

2:55 pm-1:36 pm

2 stops19h 41m

$432

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 10/9

3:35 pm-12:15 am

1 stop10h 40m

San Diego

Sun 10/12

8:00 am-6:37 pm

1 stop8h 37m

$439

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sun 9/21

1:15 pm-5:50 pm

Nonstop6h 35m

San Diego

Wed 9/24

9:08 pm-5:25 am

Nonstop6h 17m

$441

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 10/9

3:30 pm-10:27 am

2 stops20h 57m

San Diego

Sun 10/12

4:44 pm-2:14 pm

1 stop19h 30m

$443

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 9/25

2:10 pm-11:24 pm

1 stop11h 14m

San Diego

Sun 9/28

10:30 pm-12:55 pm

1 stop12h 25m

$447

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 10/23

10:00 am-11:41 pm

2 stops15h 41m

San Diego

Tue 10/28

7:50 pm-1:45 pm

2 stops15h 55m

$450

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Sat 10/18

3:15 pm-11:30 am

1 stop22h 15m

San Diego

Wed 10/29

10:45 pm-2:03 pm

1 stop13h 18m

$515

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Panama to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Panama during the month July is also very affordable. Most momondo users find prices during this month for around $429.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Panama to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $235. If your travel schedule is flexible, try to avoid departing on a Thursday because tickets tend to average around $668. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest time of day to depart on your flight to San Diego?

The cheapest time of day to fly to San Diego is at noon when flights can be purchased for as low as $344. Flights in the evening are often more expensive with an average ticket price of $1,009.

What is the cheapest Panama to San Diego flight route?

Fly from Panama City Tocumen Intl to San Diego for the best Panama - San Diego flight prices

What cabin class options are available on Panama to San Diego flights?

There are 2 cabin classes available to choose from on Panama to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama to San Diego flights?

No. A direct flight is the cheapest option for a flight between Panama to San Diego.

Cheap Panama to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to San Diego

Fastest flight time

6h 29m

Direct flights

Mon, Tue, Thu and Sat

Airports in San Diego

1 airport
The fastest flight from Panama to San Diego takes 6h 29m
Direct flights go from Panama to San Diego on Monday, Tuesday, Thursday and Saturday. The only airline offering direct flights is Copa Airlines.
There is 1 airport near San Diego: San Diego (SAN)
Search flight deals

  • When did momondo last update prices for flights from Panama to San Diego Airport?

    Prices for flights from Panama to San Diego Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Panama to San Diego Airport?

  • How old do you have to be to fly from Panama to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama to San Diego?

Best airlines flying from Panama to San Diego

Compare and see reviews for airlines that fly from Panama to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $224Free CancellationRating
7.5
1,512 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $361Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
La Mesa
National City
Imperial Beach
Poway
San Ysidro
Borrego Springs
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Panama to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Panama to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Panama to San Diego with flexible booking policies on momondo?

Flights from Panama to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama to San Diego?

Once all potential Panama to San Diego flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Panama to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Panama. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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