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Cheap flights from Panama to San Diego from $274

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama to San Diego departing on 5/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Panama to San Diego

Recent round-trip flight deals from Panama to San Diego

Enter your travel dates to find the best prices.
Copa Airlines Logo
1:39 pm - 6:30 pm
PTY
-
SAN
6h 51mnonstop
Copa Airlines Logo
10:00 pm - 6:07 am
SAN
-
PTY
6h 07mnonstop
$607Copa Airlines
Wed, May 27 - Sun, May 31
United Airlines Logo
3:30 pm - 9:59 am
PTY
-
SAN
20h 29m
2 stops
United Airlines Logo
6:15 am - 6:37 pm
SAN
-
PTY
10h 22m
1 stop
$613United Airlines
Wed, May 27 - Sun, May 31
United Airlines Logo
7:55 am - 8:04 pm
PTY
-
SAN
14h 09m
1 stop
United Airlines Logo
6:15 am - 6:37 pm
SAN
-
PTY
10h 22m
1 stop
$622United Airlines
Thu, May 7 - Mon, May 11
Copa Airlines Logo
10:00 am - 6:05 pm
PTY
-
SAN
10h 05m
1 stop
Copa Airlines Logo
6:15 am - 6:37 pm
SAN
-
PTY
10h 22m
1 stop
$624Copa Airlines
Wed, Apr 22 - Sat, May 2
United Airlines Logo
10:00 am - 5:53 pm
PTY
-
SAN
9h 53m
1 stop
United Airlines Logo
6:05 pm - 2:14 pm
SAN
-
PTY
18h 09m
2 stops
$626United Airlines
Thu, May 7 - Mon, May 11
Copa Airlines Logo
7:55 am - 8:12 pm
PTY
-
SAN
14h 17m
2 stops
Copa Airlines Logo
6:15 am - 6:37 pm
SAN
-
PTY
10h 22m
1 stop
$628Copa Airlines
Wed, Apr 22 - Sat, May 2
Delta Logo
2:27 pm - 11:25 pm
PTY
-
SAN
10h 58m
1 stop
Delta Logo
2:10 pm - 1:02 pm
SAN
-
PTY
20h 52m
1 stop
$633Delta
Wed, Apr 22 - Sat, May 2
United Airlines Logo
7:55 am - 5:41 pm
PTY
-
SAN
11h 46m
1 stop
United Airlines Logo
6:20 am - 6:37 pm
SAN
-
PTY
10h 17m
2 stops
$634United Airlines
Fri, May 22 - Mon, May 25
United Airlines Logo
3:30 pm - 11:04 am
PTY
-
SAN
21h 34m
1 stop
United Airlines Logo
6:15 am - 6:37 pm
SAN
-
PTY
10h 22m
1 stop
$639United Airlines
Mon, Apr 13 - Mon, Apr 20
United Airlines Logo
7:55 am - 5:53 pm
PTY
-
SAN
11h 58m
1 stop
United Airlines Logo
5:00 pm - 2:14 pm
SAN
-
PTY
19h 14m
1 stop
$643United Airlines
Thu, May 7 - Mon, May 11

Copa Airlines flights from Panama to San Diego

Our best Copa Airlines deals on Panama to San Diego flight tickets
Copa Airlines
May 27
PTY1:39 pmPanama City Tocumen Intl
6h 51m
SAN6:30 pmSan Diego
May 31
SAN10:00 pmSan Diego
6h 07m
PTY6:07 amPanama City Tocumen Intl
$607
Copa Airlines
Apr 22
PTY10:00 amPanama City Tocumen Intl
10h 05m
1 stop
SAN6:05 pmSan Diego
May 2
SAN6:15 amSan Diego
10h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
$624
Copa Airlines
Apr 22
PTY7:55 amPanama City Tocumen Intl
14h 17m
2 stops
SAN8:12 pmSan Diego
May 2
SAN6:15 amSan Diego
10h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
$628

United Airlines flights from Panama to San Diego

Our best United Airlines deals on Panama to San Diego flight tickets
United Airlines
May 27
PTY3:30 pmPanama City Tocumen Intl
20h 29m
2 stops
SAN9:59 amSan Diego
May 31
SAN6:15 amSan Diego
10h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
$613
United Airlines
May 7
PTY7:55 amPanama City Tocumen Intl
14h 09m
1 stop
SAN8:04 pmSan Diego
May 11
SAN6:15 amSan Diego
10h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
$622
United Airlines
May 7
PTY7:55 amPanama City Tocumen Intl
16h 21m
2 stops
SAN10:16 pmSan Diego
May 11
SAN8:45 pmSan Diego
15h 29m
2 stops
PTY2:14 pmPanama City Tocumen Intl
$626

momondo Fare Finder

 
Customize your flight search to find flights from Panama to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 4, 2026.
Use the filters below to find and compare flights from Panama to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 5/27

1:39 pm-6:30 pm

Nonstop6h 51m

San Diego

Sun 5/31

10:00 pm-6:07 am

Nonstop6h 07m

$607

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 5/27

3:30 pm-9:59 am

2 stops20h 29m

San Diego

Sun 5/31

6:15 am-6:37 pm

1 stop10h 22m

$613

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 5/7

7:55 am-8:04 pm

1 stop14h 09m

San Diego

Mon 5/11

6:15 am-6:37 pm

1 stop10h 22m

$622

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 4/22

10:00 am-6:05 pm

1 stop10h 05m

San Diego

Sat 5/2

6:15 am-6:37 pm

1 stop10h 22m

$624

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 5/7

10:00 am-5:53 pm

1 stop9h 53m

San Diego

Mon 5/11

6:05 pm-2:14 pm

2 stops18h 09m

$626

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 4/22

7:55 am-8:12 pm

2 stops14h 17m

San Diego

Sat 5/2

6:15 am-6:37 pm

1 stop10h 22m

$628

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 4/22

2:27 pm-11:25 pm

1 stop10h 58m

San Diego

Sat 5/2

2:10 pm-1:02 pm

1 stop20h 52m

$633

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 5/22

7:55 am-5:41 pm

1 stop11h 46m

San Diego

Mon 5/25

6:20 am-6:37 pm

2 stops10h 17m

$634

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Mon 4/13

3:30 pm-11:04 am

1 stop21h 34m

San Diego

Mon 4/20

6:15 am-6:37 pm

1 stop10h 22m

$639

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 5/7

7:55 am-5:53 pm

1 stop11h 58m

San Diego

Mon 5/11

5:00 pm-2:14 pm

1 stop19h 14m

$643

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Panama to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Panama during the month November is also very affordable. Most momondo users find prices during this month for around $428.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Panama to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $334. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $443. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest Panama to San Diego flight route?

Fly from Panama City Tocumen Intl to San Diego for the best Panama - San Diego flight prices

What cabin class options are available on Panama to San Diego flights?

There are 2 cabin classes available to choose from on Panama to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama to San Diego flights?

No. A direct flight is the cheapest option for a flight between Panama to San Diego.

Cheap Panama to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to San Diego

Best Price Found

$411

Fastest flight time

6h 29m

Direct flights

Mon, Tue, Thu, Fri and Sat

Airports in San Diego

1 airport
The best flight deal from Panama to San Diego found on momondo in the last 72 hours is $411
The fastest flight from Panama to San Diego takes 6h 29m
Direct flights go from Panama to San Diego on Monday, Tuesday, Thursday, Friday and Saturday. The only airline offering direct flights is Copa Airlines.
There is 1 airport in San Diego. From Panama there are direct flights to San Diego (SAN).
Search flight deals

  • When did momondo last update prices for flights from Panama to San Diego Airport?

    Prices for flights from Panama to San Diego Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Panama to San Diego Airport?

  • How old do you have to be to fly from Panama to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama to San Diego?

Best airlines flying from Panama to San Diego

Compare and see reviews for airlines that fly from Panama to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $224Free CancellationRating
7.5
1,557 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $361Free CancellationRating
7.4
9,383 reviews
Search United Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
Imperial Beach
San Ysidro
Borrego Springs
La Mesa
Alpine
Lemon Grove
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Panama to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Panama to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Panama to San Diego with flexible booking policies on momondo?

Flights from Panama to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama to San Diego?

Once all potential Panama to San Diego flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Panama to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Panama. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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