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Cheap flights from Panama to San Diego from $308

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama to San Diego departing on 5/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama to San Diego

Recent round-trip flight deals from Panama to San Diego

Enter your travel dates to find the best prices.
Copa Airlines Logo
1:39 pm - 6:30 pm
PTY
-
SAN
6h 51mnonstop
Copa Airlines Logo
10:00 pm - 6:07 am
SAN
-
PTY
6h 07mnonstop
$580Copa Airlines
Fri, May 15 - Fri, May 22
United Airlines Logo
3:30 pm - 10:09 am
PTY
-
SAN
20h 39m
2 stops
United Airlines Logo
8:45 pm - 6:37 pm
SAN
-
PTY
19h 52m
2 stops
$585United Airlines
Thu, May 14 - Sun, May 17
United Airlines Logo
7:55 am - 9:25 pm
PTY
-
SAN
15h 30m
1 stop
United Airlines Logo
6:15 am - 6:37 pm
SAN
-
PTY
10h 22m
1 stop
$637United Airlines
Fri, May 8 - Tue, May 12
United Airlines Logo
7:55 am - 5:53 pm
PTY
-
SAN
11h 58m
1 stop
United Airlines Logo
6:05 pm - 6:37 pm
SAN
-
PTY
22h 32m
2 stops
$641United Airlines
Fri, May 8 - Tue, May 12
Copa Airlines Logo
10:00 am - 5:53 pm
PTY
-
SAN
9h 53m
1 stop
Copa Airlines Logo
5:15 pm - 4:12 pm
SAN
-
PTY
20h 57m
1 stop
$656Copa Airlines
Fri, May 15 - Fri, May 22
Copa Airlines Logo
7:55 am - 10:16 pm
PTY
-
SAN
16h 21m
2 stops
Copa Airlines Logo
5:15 pm - 4:12 pm
SAN
-
PTY
20h 57m
1 stop
$661Copa Airlines
Fri, May 15 - Fri, May 22
United Airlines Logo
7:55 am - 11:59 pm
PTY
-
SAN
18h 04m
2 stops
United Airlines Logo
8:32 pm - 6:37 pm
SAN
-
PTY
20h 05m
2 stops
$669United Airlines
Fri, May 15 - Fri, May 22
Copa Airlines Logo
1:55 pm - 6:30 pm
PTY
-
SAN
6h 35mnonstop
Copa Airlines Logo
9:03 pm - 5:20 am
SAN
-
PTY
6h 17mnonstop
$714Copa Airlines
Wed, Sep 9 - Sun, Sep 13
United Airlines Logo
10:00 am - 10:25 pm
PTY
-
SAN
14h 25m
2 stops
United Airlines Logo
8:32 pm - 6:37 pm
SAN
-
PTY
20h 05m
2 stops
$718United Airlines
Thu, Jul 2 - Fri, Jul 10
United Airlines Logo
10:00 am - 11:54 pm
PTY
-
SAN
15h 54m
2 stops
United Airlines Logo
7:41 pm - 2:14 pm
SAN
-
PTY
16h 33m
2 stops
$719United Airlines
Thu, Jul 2 - Fri, Jul 10

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GOL flights from Panama to San Diego

Our best GOL deals on Panama to San Diego flight tickets
GOL
Sep 20
PTY3:40 pmPanama City Tocumen Intl
22h 27m
2 stops
SAN12:07 pmSan Diego
Sep 30
SAN11:00 pmSan Diego
13h 10m
2 stops
PTY2:10 pmPanama City Tocumen Intl
$741
GOL
Jun 14
PTY1:14 pmPanama City Tocumen Intl
25h 19m
2 stops
SAN12:33 pmSan Diego
Jun 21
SAN9:47 amSan Diego
24h 27m
2 stops
PTY12:14 pmPanama City Tocumen Intl
$955

American Airlines flights from Panama to San Diego

Our best American Airlines deals on Panama to San Diego flight tickets
American Airlines
Sep 9
PTY3:40 pmPanama City Tocumen Intl
22h 27m
2 stops
SAN12:07 pmSan Diego
Sep 13
SAN11:58 pmSan Diego
12h 12m
1 stop
PTY2:10 pmPanama City Tocumen Intl
$752
American Airlines
Jun 3
PTY1:14 pmPanama City Tocumen Intl
22h 01m
2 stops
SAN9:15 amSan Diego
Jun 10
SAN1:55 pmSan Diego
20h 19m
2 stops
PTY12:14 pmPanama City Tocumen Intl
$759
American Airlines
May 27
PTY1:14 pmPanama City Tocumen Intl
11h 06m
1 stop
SAN10:20 pmSan Diego
May 31
SAN12:36 pmSan Diego
21h 38m
1 stop
PTY12:14 pmPanama City Tocumen Intl
$800

momondo Fare Finder

 
Customize your flight search to find flights from Panama to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 20, 2026.
Use the filters below to find and compare flights from Panama to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 5/15

1:39 pm-6:30 pm

Nonstop6h 51m

San Diego

Fri 5/22

10:00 pm-6:07 am

Nonstop6h 07m

$580

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 5/14

3:30 pm-10:09 am

2 stops20h 39m

San Diego

Sun 5/17

8:45 pm-6:37 pm

2 stops19h 52m

$585

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 5/8

7:55 am-9:25 pm

1 stop15h 30m

San Diego

Tue 5/12

6:15 am-6:37 pm

1 stop10h 22m

$637

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 5/8

7:55 am-5:53 pm

1 stop11h 58m

San Diego

Tue 5/12

6:05 pm-6:37 pm

2 stops22h 32m

$641

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 5/15

10:00 am-5:53 pm

1 stop9h 53m

San Diego

Fri 5/22

5:15 pm-4:12 pm

1 stop20h 57m

$656

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 5/15

7:55 am-10:16 pm

2 stops16h 21m

San Diego

Fri 5/22

5:15 pm-4:12 pm

1 stop20h 57m

$661

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Fri 5/15

7:55 am-11:59 pm

2 stops18h 04m

San Diego

Fri 5/22

8:32 pm-6:37 pm

2 stops20h 05m

$669
Quickest round-trip

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Wed 9/9

1:55 pm-6:30 pm

Nonstop6h 35m

San Diego

Sun 9/13

9:03 pm-5:20 am

Nonstop6h 17m

$714

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 7/2

10:00 am-10:25 pm

2 stops14h 25m

San Diego

Fri 7/10

8:32 pm-6:37 pm

2 stops20h 05m

$718

Panama CitySan Diego

PTY - SAN

PTYSAN

Panama City Tocumen Intl

Thu 7/2

10:00 am-11:54 pm

2 stops15h 54m

San Diego

Fri 7/10

7:41 pm-2:14 pm

2 stops16h 33m

$719

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Panama to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of October, then departing from Panama during the month November is also very affordable. Most momondo users find prices during this month for around $428.

What is the cheapest day to depart on your flight to San Diego?

The cheapest day to depart from Panama to San Diego is on a Monday. Travelers who choose to depart for San Diego on a Monday will often find tickets for as low as $334. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $516. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

What is the cheapest Panama to San Diego flight route?

Fly from Panama City Tocumen Intl to San Diego for the best Panama - San Diego flight prices

What cabin class options are available on Panama to San Diego flights?

There are 2 cabin classes available to choose from on Panama to San Diego flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama to San Diego flights?

You could potentially save up to 10% on your flight if you consider stops on a Panama to San Diego flight.

Cheap Panama to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to San Diego

Best Price Found

$516

Fastest flight time

6h 29m

Direct flights

Mon, Tue, Thu, Fri and Sat

Airports in San Diego

1 airport
The best flight deal from Panama to San Diego found on momondo in the last 72 hours is $516
The fastest flight from Panama to San Diego takes 6h 29m
Direct flights go from Panama to San Diego on Monday, Tuesday, Thursday, Friday and Saturday. The only airline offering direct flights is Copa Airlines.
There is 1 airport in San Diego. From Panama there are direct flights to San Diego (SAN).
Search flight deals

Frequently asked questions about flying from Panama to San Diego

  • When did momondo last update prices for flights from Panama to San Diego Airport?

    Prices for flights from Panama to San Diego Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Panama to San Diego Airport?

  • How old do you have to be to fly from Panama to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama to San Diego?

Best airlines flying from Panama to San Diego

Compare and see reviews for airlines that fly from Panama to San Diego with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $224Free CancellationRating
7.5
1,581 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $361Free CancellationRating
7.4
9,608 reviews
Search United Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
San Ysidro
La Mesa
Imperial Beach
Borrego Springs
Lemon Grove
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Panama to San Diego?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Panama to San Diego. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Panama to San Diego with flexible booking policies on momondo?

Flights from Panama to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama to San Diego?

Once all potential Panama to San Diego flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Panama to San Diego right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Diego from Panama. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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