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Cheap flights from Panama City, Florida to San Francisco from $279

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to San Francisco departing on 1/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Panama City, Florida to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
1:10 pm - 7:00 pm
ECP
-
SFO
7h 50m1 stop
United Airlines Logo
12:43 am - 12:02 pm
SFO
-
ECP
9h 19m1 stop
$301United Airlines
Sat, Jan 17 - Sat, Jan 17
United Airlines Logo
6:30 am - 2:56 pm
ECP
-
SFO
10h 26m1 stop
United Airlines Logo
12:43 am - 12:02 pm
SFO
-
ECP
9h 19m1 stop
$330United Airlines
Sun, Jan 18 - Mon, Jan 26
American Airlines Logo
12:03 pm - 10:50 pm
ECP
-
SFO
12h 47m2 stops
American Airlines Logo
10:11 am - 9:12 pm
SFO
-
ECP
9h 01m1 stop
$346American Airlines
Sat, Jan 17 - Sun, Jan 18
American Airlines Logo
7:02 am - 1:46 pm
ECP
-
SFO
8h 44m1 stop
American Airlines Logo
7:00 am - 9:19 pm
SFO
-
ECP
12h 19m2 stops
$375American Airlines
Sun, Jan 18 - Tue, Jan 27
Delta Logo
6:00 am - 12:55 pm
ECP
-
SFO
8h 55m1 stop
Delta Logo
4:03 pm - 8:39 am
SFO
-
ECP
14h 36m2 stops
$378Delta
Sun, Jan 18 - Tue, Jan 27
American Airlines Logo
12:03 pm - 10:50 pm
ECP
-
SFO
12h 47m2 stops
American Airlines Logo
9:10 am - 9:12 pm
SFO
-
ECP
10h 02m2 stops
$409American Airlines
Sat, Jan 17 - Sun, Jan 18
United Airlines Logo
6:30 am - 12:20 pm
ECP
-
SFO
7h 50m1 stop
United Airlines Logo
5:00 am - 4:12 pm
SFO
-
ECP
9h 12m1 stop
$411United Airlines
Sat, Jan 24 - Sun, Jan 25
American Airlines Logo
12:03 pm - 9:37 pm
ECP
-
SFO
11h 34m2 stops
American Airlines Logo
6:00 am - 2:54 pm
SFO
-
ECP
6h 54m1 stop
$416American Airlines
Sat, Jan 24 - Sun, Jan 25
American Airlines Logo
7:02 am - 6:30 pm
ECP
-
SFO
13h 28m2 stops
American Airlines Logo
7:00 am - 9:19 pm
SFO
-
ECP
12h 19m2 stops
$420American Airlines
Sun, Jan 18 - Tue, Jan 27
American Airlines Logo
12:37 pm - 8:42 pm
ECP
-
SFO
10h 05m2 stops
American Airlines Logo
9:15 am - 9:57 pm
SFO
-
ECP
10h 42m2 stops
$426American Airlines
Sun, Feb 15 - Thu, Feb 19

Delta flights from Panama City, Florida to San Francisco

Our best Delta deals on Panama City, Florida to San Francisco flight tickets
Delta
Jun 19
ECP2:47 pmPanama City NW Florida Beaches
8h 48m
1 stop
SFO9:35 pmSan Francisco
Jul 2
SFO9:30 pmSan Francisco
8h 47m
1 stop
ECP8:17 amPanama City NW Florida Beaches
$437
Find similar
Delta
Jan 7
ECP5:14 pmPanama City NW Florida Beaches
8h 11m
1 stop
SFO11:25 pmSan Francisco
Jan 11
SFO2:05 pmSan Francisco
6h 46m
1 stop
ECP10:51 pmPanama City NW Florida Beaches
$557
Find similar
Delta
Jun 19
ECP2:47 pmPanama City NW Florida Beaches
8h 48m
1 stop
SFO9:35 pmSan Francisco
Jul 2
SFO9:30 pmSan Francisco
8h 47m
1 stop
ECP8:17 amPanama City NW Florida Beaches
$712
Find similar

Southwest flights from Panama City, Florida to San Francisco

Our best Southwest deals on Panama City, Florida to San Francisco flight tickets
Southwest
Jun 7
ECP5:40 amPanama City NW Florida Beaches
8h 05m
2 stops
SFO11:45 amSan Francisco
Jun 10
SFO12:20 pmSan Francisco
6h 50m
1 stop
ECP9:10 pmPanama City NW Florida Beaches
$462
Find similar
Southwest
Jun 7
ECP5:40 amPanama City NW Florida Beaches
8h 05m
2 stops
SFO11:45 amSan Francisco
Jun 10
SFO7:15 amSan Francisco
11h 25m
2 stops
ECP8:40 pmPanama City NW Florida Beaches
$467
Find similar
Southwest
Jun 7
ECP4:20 pmPanama City NW Florida Beaches
9h 45m
1 stop
SFO12:05 amSan Francisco
Jun 10
SFO12:20 pmSan Francisco
6h 50m
1 stop
ECP9:10 pmPanama City NW Florida Beaches
$498
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momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Panama City, Florida to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sat 1/17

1:10 pm-7:00 pm

1 stop7h 50m

San Francisco

Sat 1/17

12:43 am-12:02 pm

1 stop9h 19m

$301

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sun 1/18

6:30 am-2:56 pm

1 stop10h 26m

San Francisco

Mon 1/26

12:43 am-12:02 pm

1 stop9h 19m

$330

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sat 1/17

12:03 pm-10:50 pm

2 stops12h 47m

San Francisco

Sun 1/18

10:11 am-9:12 pm

1 stop9h 01m

$346

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sun 1/18

7:02 am-1:46 pm

1 stop8h 44m

San Francisco

Tue 1/27

7:00 am-9:19 pm

2 stops12h 19m

$375

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sun 1/18

6:00 am-12:55 pm

1 stop8h 55m

San Francisco

Tue 1/27

4:03 pm-8:39 am

2 stops14h 36m

$378

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sat 1/17

12:03 pm-10:50 pm

2 stops12h 47m

San Francisco

Sun 1/18

9:10 am-9:12 pm

2 stops10h 02m

$409

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sat 1/24

6:30 am-12:20 pm

1 stop7h 50m

San Francisco

Sun 1/25

5:00 am-4:12 pm

1 stop9h 12m

$411

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sat 1/24

12:03 pm-9:37 pm

2 stops11h 34m

San Francisco

Sun 1/25

6:00 am-2:54 pm

1 stop6h 54m

$416

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sun 1/18

7:02 am-6:30 pm

2 stops13h 28m

San Francisco

Tue 1/27

7:00 am-9:19 pm

2 stops12h 19m

$420

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sun 2/15

12:37 pm-8:42 pm

2 stops10h 05m

San Francisco

Thu 2/19

9:15 am-9:57 pm

2 stops10h 42m

$426

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Panama City, Florida to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City, Florida and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of April, then flying in February is also cheap. Prices for this month can be found on momondo for an average of $379.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Panama City, Florida to San Francisco is on a Tuesday when prices can be found for as low as $400. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $491.

How have Panama City, Florida to San Francisco flight prices changed over time?

As of December 2025, prices for Panama City, Florida to San Francisco flights are approximately 93% more expensive when compared to flights at the same time last year.

When to book flights from Panama City, Florida to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to San Francisco (ECP to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to San Francisco

Fastest flight time

7h 41m

Direct flights

None
The fastest flight from Panama City, Florida to San Francisco takes 7h 41m
There are no direct flights from Panama City, Florida to San Francisco. There are no popular flight routes from Panama City, Florida to San Francisco.
Search flight deals

  • How far is Panama City NW Florida Beaches to San Francisco by plane?

    Panama City NW Florida Beaches and San Francisco are 2154.5 mi apart from one another. A reasonable flight in good conditions will take 7h 41m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to San Francisco Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to San Francisco Airport are updated daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to San Francisco Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama City NW Florida Beaches Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to San Francisco?

Best airlines flying from Panama City, Florida to San Francisco

Compare and see reviews for airlines that fly from Panama City, Florida to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $297Free CancellationRating
7.9
8,014 reviews
Search Delta flights
United AirlinesPriceFrom $306Free CancellationRating
7.4
9,105 reviews
Search United Airlines flights
American AirlinesPriceFrom $360Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
SouthwestPriceFrom $389Free CancellationRating
8.0
4,253 reviews
Search Southwest flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Berkeley
Santa Clara
Walnut Creek
Fremont
Daly City
Half Moon Bay
Vallejo
Salinas
Livermore
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to San Francisco?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to San Francisco for you.

Can I find flights from Panama City to San Francisco with flexible booking policies on momondo?

All flight searches from Panama City to San Francisco on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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