Cheap flights from North Carolina to San Diego from $110

If you are unable to visit San Diego during the month of February, then departing from North Carolina during the month August is also very affordable. Most momondo users find prices during this month for around $99.

The cheapest day to depart from North Carolina to San Diego is on a Wednesday. Travelers who choose to depart for San Diego on a Wednesday will often find tickets for as low as $239. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $317. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

The cheapest time of day to fly to San Diego is in the evening when flights can be purchased for as low as $257. Flights in the afternoon are often more expensive with an average ticket price of $325.

Fly from Raleigh-Durham to San Diego for the best North Carolina - San Diego flight prices

You are more likely to see cheaper flights to San Diego from North Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $333 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from North Carolina for as low as $258 on momondo.

Frontier, Delta, and United Airlines are the most popular carriers operating from North Carolina to San Diego

American Airlines, Delta and Southwest are the top three most popular airlines that fly to San Diego from North Carolina according to our data. American Airlines is the first choice among our users, with 66% of people opting to fly with this airline when traveling to San Diego. Keep in mind that there are 9 different airlines that fly to San Diego on a routine basis, so you have a few additional options to choose from.

The number of flights available between North Carolina and San Diego is 8 per day as of May 2026. The most frequent departure time is 11:00AM, with 43% of daily flights leaving at noon.

The number of flights available between North Carolina and San Diego is 57 per week as of May 2026. The most frequent departure day is Mon, with 19% of weekly flights leaving on this day.