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Cheap flights from Myrtle Beach to Los Angeles from $325

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Los Angeles departing on 1/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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American Airlines Logo
1:53 pm - 8:02 pmMYR-SNA
9h 09m1 stop
American Airlines Logo
8:55 am - 6:49 pmSNA-MYR
6h 54m1 stop
$325American Airlines
Find Deal
Thu, Jan 29 - Tue, Feb 3
American Airlines Logo
1:53 pm - 8:02 pmMYR-SNA
9h 09m1 stop
American Airlines Logo
7:50 am - 8:54 pmSNA-MYR
10h 04m2 stops
$330American Airlines
Find Deal
Thu, Jan 29 - Tue, Feb 3
American Airlines Logo
6:23 am - 2:09 pmMYR-SNA
10h 46m2 stops
American Airlines Logo
7:00 am - 8:54 pmSNA-MYR
10h 54m2 stops
$335American Airlines
Find Deal
Thu, Jan 29 - Tue, Feb 3
American Airlines Logo
5:33 pm - 10:13 pmMYR-SNA
7h 40m1 stop
American Airlines Logo
8:28 am - 7:13 pmSNA-MYR
7h 45m1 stop
$482American Airlines
Find Deal
Tue, Mar 3 - Wed, Mar 4
American Airlines Logo
2:28 pm - 8:24 pmMYR-SNA
8h 56m1 stop
American Airlines Logo
8:28 am - 7:13 pmSNA-MYR
7h 45m1 stop
$485American Airlines
Find Deal
Tue, Mar 3 - Wed, Mar 4
American Airlines Logo
2:28 pm - 8:24 pmMYR-SNA
8h 56m1 stop
American Airlines Logo
8:00 pm - 8:24 amSNA-MYR
9h 24m2 stops
$487American Airlines
Find Deal
Tue, Mar 3 - Wed, Mar 4
American Airlines Logo
2:28 pm - 9:43 pmMYR-SNA
10h 15m2 stops
American Airlines Logo
8:28 am - 5:27 pmSNA-MYR
5h 59m1 stop
$490American Airlines
Find Deal
Tue, Mar 3 - Wed, Mar 4
American Airlines Logo
2:28 pm - 9:43 pmMYR-SNA
10h 15m2 stops
American Airlines Logo
8:00 pm - 8:24 amSNA-MYR
9h 24m2 stops
$492American Airlines
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Tue, Mar 3 - Wed, Mar 4
United Airlines Logo
11:20 am - 5:38 pmMYR-SNA
9h 18m1 stop
United Airlines Logo
6:40 pm - 10:39 amSNA-MYR
12h 59m2 stops
$552United Airlines
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Wed, Oct 15 - Sun, Oct 19
United Airlines Logo
11:20 am - 10:30 pmMYR-SNA
14h 10m2 stops
United Airlines Logo
6:40 pm - 10:39 amSNA-MYR
12h 59m2 stops
$557United Airlines
Find Deal
Wed, Oct 15 - Sun, Oct 19

American Airlines flights from Myrtle Beach to Santa Ana

Our best American Airlines deals on Myrtle Beach to Santa Ana flight tickets
American Airlines
Jan 29
MYR1:53 pmMyrtle Beach Intl
9h 09m
1 stop
SNA8:02 pmSanta Ana J. Wayne/Orange Cnty
Feb 3
SNA8:55 amSanta Ana J. Wayne/Orange Cnty
6h 54m
1 stop
MYR6:49 pmMyrtle Beach Intl
$325
Find similar
American Airlines
Jan 29
MYR1:53 pmMyrtle Beach Intl
9h 09m
1 stop
SNA8:02 pmSanta Ana J. Wayne/Orange Cnty
Feb 3
SNA7:50 amSanta Ana J. Wayne/Orange Cnty
10h 04m
2 stops
MYR8:54 pmMyrtle Beach Intl
$330
Find similar
American Airlines
Jan 29
MYR6:23 amMyrtle Beach Intl
10h 46m
2 stops
SNA2:09 pmSanta Ana J. Wayne/Orange Cnty
Feb 3
SNA7:00 amSanta Ana J. Wayne/Orange Cnty
10h 54m
2 stops
MYR8:54 pmMyrtle Beach Intl
$335
Find similar

United Airlines flights from Myrtle Beach to Santa Ana

Our best United Airlines deals on Myrtle Beach to Santa Ana flight tickets
United Airlines
Oct 15
MYR11:20 amMyrtle Beach Intl
9h 18m
1 stop
SNA5:38 pmSanta Ana J. Wayne/Orange Cnty
Oct 19
SNA6:40 pmSanta Ana J. Wayne/Orange Cnty
12h 59m
2 stops
MYR10:39 amMyrtle Beach Intl
$552
Find similar
United Airlines
Oct 15
MYR11:20 amMyrtle Beach Intl
14h 10m
2 stops
SNA10:30 pmSanta Ana J. Wayne/Orange Cnty
Oct 19
SNA6:40 pmSanta Ana J. Wayne/Orange Cnty
12h 59m
2 stops
MYR10:39 amMyrtle Beach Intl
$557
Find similar
United Airlines
Oct 15
MYR4:33 pmMyrtle Beach Intl
8h 57m
1 stop
SNA10:30 pmSanta Ana J. Wayne/Orange Cnty
Oct 19
SNA9:05 pmSanta Ana J. Wayne/Orange Cnty
10h 34m
1 stop
MYR10:39 amMyrtle Beach Intl
$649
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 2, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Santa Ana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Thu 1/29

1:53 pm-8:02 pm

1 stop9h 09m

Santa Ana J. Wayne/Orange Cnty

Tue 2/3

8:55 am-6:49 pm

1 stop6h 54m

$325

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Thu 1/29

1:53 pm-8:02 pm

1 stop9h 09m

Santa Ana J. Wayne/Orange Cnty

Tue 2/3

7:50 am-8:54 pm

2 stops10h 04m

$330

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Thu 1/29

6:23 am-2:09 pm

2 stops10h 46m

Santa Ana J. Wayne/Orange Cnty

Tue 2/3

7:00 am-8:54 pm

2 stops10h 54m

$335

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 3/3

5:33 pm-10:13 pm

1 stop7h 40m

Santa Ana J. Wayne/Orange Cnty

Wed 3/4

8:28 am-7:13 pm

1 stop7h 45m

$482

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 3/3

2:28 pm-8:24 pm

1 stop8h 56m

Santa Ana J. Wayne/Orange Cnty

Wed 3/4

8:28 am-7:13 pm

1 stop7h 45m

$485

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 3/3

2:28 pm-8:24 pm

1 stop8h 56m

Santa Ana J. Wayne/Orange Cnty

Wed 3/4

8:00 pm-8:24 am

2 stops9h 24m

$487

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 3/3

2:28 pm-9:43 pm

2 stops10h 15m

Santa Ana J. Wayne/Orange Cnty

Wed 3/4

8:28 am-5:27 pm

1 stop5h 59m

$490

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 3/3

2:28 pm-9:43 pm

2 stops10h 15m

Santa Ana J. Wayne/Orange Cnty

Wed 3/4

8:00 pm-8:24 am

2 stops9h 24m

$492

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Wed 10/15

11:20 am-5:38 pm

1 stop9h 18m

Santa Ana J. Wayne/Orange Cnty

Sun 10/19

6:40 pm-10:39 am

2 stops12h 59m

$552

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Wed 10/15

11:20 am-10:30 pm

2 stops14h 10m

Santa Ana J. Wayne/Orange Cnty

Sun 10/19

6:40 pm-10:39 am

2 stops12h 59m

$557

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Myrtle Beach to Santa Ana

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Myrtle Beach and Santa Ana?

What is the cheapest day to depart on your flight to Santa Ana?

On average, the least expensive day to fly to Santa Ana from Myrtle Beach is on a Saturday. momondo users have found tickets for Saturday departures for as low as $403. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Monday is the most expensive day to depart from Myrtle Beach because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $611.

What is the cheapest time of day to depart on your flight to Santa Ana?

Our data shows that the cheapest Myrtle Beach to Santa Ana flights are usually those with departure times in the morning. Our users have found flights to Santa Ana in the morning for as low as $463. Try not to purchase tickets at noon because they tend to be around $564. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Myrtle Beach to Santa Ana flights?

You could potentially save up to 55% on your flight if you consider stops on a Myrtle Beach to Santa Ana flight.

When to book flights from Myrtle Beach to Santa Ana

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Santa Ana according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Santa Ana (MYR to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Santa Ana

Direct flights

None
There are no direct flights from Myrtle Beach to Santa Ana. There are no popular flight routes from Myrtle Beach to Santa Ana.
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  • How far is Myrtle Beach Intl to Santa Ana J. Wayne/Orange Cnty by plane?

    Myrtle Beach Intl and Santa Ana J. Wayne/Orange Cnty are 2225.0 mi apart from one another. Typically, this will take 7h 40m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport refresh daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The required travel and health documents for your Santa Ana J. Wayne/Orange Cnty Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to Santa Ana?

Best airlines flying from Myrtle Beach to Santa Ana

Compare and see reviews for airlines that fly from Myrtle Beach to Santa Ana with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $319Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

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Why should I use momondo to find a flight deal from Myrtle Beach to Santa Ana?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Myrtle Beach to Santa Ana. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Myrtle Beach to Santa Ana with flexible booking policies on momondo?

Flights from Myrtle Beach to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Myrtle Beach to Santa Ana?

Once all potential Myrtle Beach to Santa Ana flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Santa Ana right now. Can momondo alert me if prices change?

Price alerts on flights to Santa Ana from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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