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Cheap flights from Myrtle Beach to Los Angeles from $180

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Los Angeles departing on 3/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
9:09 am - 8:57 pm
MYR
-
SNA
38h 48m
3 stops
Spirit Airlines Logo
4:37 pm - 8:13 am
SNA
-
MYR
12h 36m
2 stops
$331Spirit Airlines
Mon, Feb 23 - Mon, Mar 2
Spirit Airlines Logo
9:09 am - 8:57 pm
MYR
-
SNA
38h 48m
3 stops
Spirit Airlines Logo
1:20 pm - 2:55 pm
SNA
-
MYR
22h 35m
3 stops
$347Spirit Airlines
Mon, Feb 23 - Mon, Mar 2
Spirit Airlines Logo
9:09 am - 12:25 pm
MYR
-
SNA
30h 16m
2 stops
Spirit Airlines Logo
1:20 pm - 8:13 am
SNA
-
MYR
15h 53m
2 stops
$349Spirit Airlines
Mon, Feb 23 - Mon, Mar 2
American Airlines Logo
1:53 pm - 8:02 pm
MYR
-
SNA
9h 09m
1 stop
American Airlines Logo
5:01 pm - 8:54 am
SNA
-
MYR
12h 53m
2 stops
$364American Airlines
Tue, Feb 10 - Sat, Feb 14
American Airlines Logo
6:23 am - 3:33 pm
MYR
-
SNA
12h 10m
2 stops
American Airlines Logo
9:23 am - 11:55 pm
SNA
-
MYR
11h 32m
2 stops
$370American Airlines
Tue, Feb 10 - Sat, Feb 14
Delta Logo
4:00 pm - 8:10 pm
MYR
-
SNA
7h 10m
1 stop
Delta Logo
11:56 am - 12:04 am
SNA
-
MYR
9h 08m
1 stop
$374Delta
Tue, Feb 24 - Wed, Mar 11
Delta Logo
1:08 pm - 9:57 pm
MYR
-
SNA
11h 49m
2 stops
Delta Logo
11:56 am - 12:04 am
SNA
-
MYR
9h 08m
1 stop
$379Delta
Tue, Feb 24 - Wed, Mar 11
American Airlines Logo
10:26 am - 7:31 pm
MYR
-
SNA
12h 05m
2 stops
American Airlines Logo
7:48 pm - 8:32 am
SNA
-
MYR
9h 44m
2 stops
$385American Airlines
Tue, Feb 24 - Wed, Mar 11
Spirit Airlines Logo
8:15 pm - 8:57 pm
MYR
-
SNA
27h 42m
3 stops
Spirit Airlines Logo
4:37 pm - 8:13 am
SNA
-
MYR
12h 36m
2 stops
$388Spirit Airlines
Tue, Feb 10 - Sat, Feb 14
American Airlines Logo
5:18 pm - 10:47 pm
MYR
-
SNA
8h 29m
1 stop
American Airlines Logo
7:48 pm - 8:20 am
SNA
-
MYR
9h 32m
2 stops
$411American Airlines
Thu, Feb 12 - Fri, Feb 13

American Airlines flights from Myrtle Beach to Santa Ana, California

Our best American Airlines deals on Myrtle Beach to Santa Ana, California flight tickets
American Airlines
Feb 10
MYR1:53 pmMyrtle Beach Intl
9h 09m
1 stop
SNA8:02 pmSanta Ana J. Wayne/Orange Cnty
Feb 14
SNA5:01 pmSanta Ana J. Wayne/Orange Cnty
12h 53m
2 stops
MYR8:54 amMyrtle Beach Intl
$364
American Airlines
Feb 10
MYR6:23 amMyrtle Beach Intl
12h 10m
2 stops
SNA3:33 pmSanta Ana J. Wayne/Orange Cnty
Feb 14
SNA9:23 amSanta Ana J. Wayne/Orange Cnty
11h 32m
2 stops
MYR11:55 pmMyrtle Beach Intl
$370
American Airlines
Feb 24
MYR10:26 amMyrtle Beach Intl
12h 05m
2 stops
SNA7:31 pmSanta Ana J. Wayne/Orange Cnty
Mar 11
SNA7:48 pmSanta Ana J. Wayne/Orange Cnty
9h 44m
2 stops
MYR8:32 amMyrtle Beach Intl
$385

Delta flights from Myrtle Beach to Santa Ana, California

Our best Delta deals on Myrtle Beach to Santa Ana, California flight tickets
Delta
Feb 24
MYR4:00 pmMyrtle Beach Intl
7h 10m
1 stop
SNA8:10 pmSanta Ana J. Wayne/Orange Cnty
Mar 11
SNA11:56 amSanta Ana J. Wayne/Orange Cnty
9h 08m
1 stop
MYR12:04 amMyrtle Beach Intl
$374
Delta
Feb 24
MYR1:08 pmMyrtle Beach Intl
11h 49m
2 stops
SNA9:57 pmSanta Ana J. Wayne/Orange Cnty
Mar 11
SNA11:56 amSanta Ana J. Wayne/Orange Cnty
9h 08m
1 stop
MYR12:04 amMyrtle Beach Intl
$379
Delta
May 8
MYR3:40 pmMyrtle Beach Intl
6h 56m
1 stop
SNA7:36 pmSanta Ana J. Wayne/Orange Cnty
May 11
SNA9:20 pmSanta Ana J. Wayne/Orange Cnty
11h 36m
2 stops
MYR11:56 amMyrtle Beach Intl
$423

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santa Ana, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Mon 2/23

9:09 am-8:57 pm

3 stops38h 48m

Santa Ana J. Wayne/Orange Cnty

Mon 3/2

4:37 pm-8:13 am

2 stops12h 36m

$331

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Mon 2/23

9:09 am-8:57 pm

3 stops38h 48m

Santa Ana J. Wayne/Orange Cnty

Mon 3/2

1:20 pm-2:55 pm

3 stops22h 35m

$347

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Mon 2/23

9:09 am-12:25 pm

2 stops30h 16m

Santa Ana J. Wayne/Orange Cnty

Mon 3/2

1:20 pm-8:13 am

2 stops15h 53m

$349

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 2/10

1:53 pm-8:02 pm

1 stop9h 09m

Santa Ana J. Wayne/Orange Cnty

Sat 2/14

5:01 pm-8:54 am

2 stops12h 53m

$364

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 2/10

6:23 am-3:33 pm

2 stops12h 10m

Santa Ana J. Wayne/Orange Cnty

Sat 2/14

9:23 am-11:55 pm

2 stops11h 32m

$370

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 2/24

4:00 pm-8:10 pm

1 stop7h 10m

Santa Ana J. Wayne/Orange Cnty

Wed 3/11

11:56 am-12:04 am

1 stop9h 08m

$374

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 2/24

1:08 pm-9:57 pm

2 stops11h 49m

Santa Ana J. Wayne/Orange Cnty

Wed 3/11

11:56 am-12:04 am

1 stop9h 08m

$379

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 2/24

10:26 am-7:31 pm

2 stops12h 05m

Santa Ana J. Wayne/Orange Cnty

Wed 3/11

7:48 pm-8:32 am

2 stops9h 44m

$385

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 2/10

8:15 pm-8:57 pm

3 stops27h 42m

Santa Ana J. Wayne/Orange Cnty

Sat 2/14

4:37 pm-8:13 am

2 stops12h 36m

$388

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Thu 2/12

5:18 pm-10:47 pm

1 stop8h 29m

Santa Ana J. Wayne/Orange Cnty

Fri 2/13

7:48 pm-8:20 am

2 stops9h 32m

$411

Flights are sorted by cheapest round-trip flights first.

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How to get the cheapest flight ticket from Myrtle Beach to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Myrtle Beach to Santa Ana, California flights?

You could potentially save up to 5% on your flight if you consider stops on a Myrtle Beach to Santa Ana, California flight.

When to book flights from Myrtle Beach to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Santa Ana, California (MYR to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Santa Ana, California

Fastest flight time

8h 26m

Direct flights

None
The fastest flight from Myrtle Beach to Santa Ana, California takes 8h 26m
There are no direct flights from Myrtle Beach to Santa Ana, California. There are no popular flight routes from Myrtle Beach to Santa Ana, California.
Search flight deals

  • How far is Myrtle Beach Intl to Santa Ana J. Wayne/Orange Cnty by plane?

    Myrtle Beach Intl and Santa Ana J. Wayne/Orange Cnty are 2225.0 mi apart from one another. Typically, this will take 8h 26m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport refresh daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The required travel and health documents for your Santa Ana J. Wayne/Orange Cnty Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to Santa Ana, California?

Best airlines flying from Myrtle Beach to Santa Ana, California

Compare and see reviews for airlines that fly from Myrtle Beach to Santa Ana, California with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $312Free CancellationRating
7.2
11,201 reviews
Search American Airlines flights

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
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Why should I use momondo to find a flight deal from Myrtle Beach to Santa Ana?

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Can I find flights from Myrtle Beach to Santa Ana with flexible booking policies on momondo?

Flights from Myrtle Beach to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Myrtle Beach to Santa Ana?

Once all potential Myrtle Beach to Santa Ana flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Santa Ana right now. Can momondo alert me if prices change?

Price alerts on flights to Santa Ana from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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