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Cheap flights from Myrtle Beach to Los Angeles from $157

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Los Angeles departing on 5/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
12:00 pm - 9:45 pm
MYR
-
SNA
12h 45m
2 stops
Spirit Airlines Logo
3:23 pm - 10:55 am
SNA
-
MYR
16h 32m
2 stops
$382Spirit Airlines
Wed, Jun 3 - Wed, Jun 10
Spirit Airlines Logo
12:00 pm - 9:45 pm
MYR
-
SNA
12h 45m
2 stops
Spirit Airlines Logo
3:23 pm - 10:55 am
SNA
-
MYR
16h 32m
2 stops
$392Spirit Airlines
Wed, Jun 3 - Wed, Jun 10
Spirit Airlines Logo
12:00 pm - 9:45 pm
MYR
-
SNA
12h 45m
2 stops
Spirit Airlines Logo
3:23 pm - 10:55 am
SNA
-
MYR
16h 32m
2 stops
$394Spirit Airlines
Tue, May 19 - Thu, Jun 4
American Airlines Logo
5:00 am - 1:49 pm
MYR
-
SNA
11h 49m
2 stops
American Airlines Logo
8:17 am - 10:22 pm
SNA
-
MYR
11h 05m
2 stops
$415American Airlines
Sat, Apr 18 - Sat, Apr 25
Delta Logo
4:07 pm - 10:29 pm
MYR
-
SNA
9h 22m
1 stop
Delta Logo
7:15 pm - 10:26 am
SNA
-
MYR
12h 11m
2 stops
$426Delta
Wed, Jun 3 - Wed, Jun 10
American Airlines Logo
1:55 pm - 9:14 pm
MYR
-
SNA
10h 19m
1 stop
American Airlines Logo
8:17 am - 10:22 pm
SNA
-
MYR
11h 05m
2 stops
$428American Airlines
Sat, Apr 18 - Sat, Apr 25
United Airlines Logo
3:15 pm - 10:35 pm
MYR
-
SNA
10h 20m
1 stop
United Airlines Logo
6:39 pm - 10:18 am
SNA
-
MYR
12h 39m
2 stops
$430United Airlines
Tue, Apr 21 - Sun, Apr 26
Delta Logo
3:57 pm - 8:57 pm
MYR
-
SNA
8h 00m
1 stop
Delta Logo
1:11 pm - 12:14 am
SNA
-
MYR
8h 03m
1 stop
$432Delta
Sat, Apr 18 - Sat, Apr 25
United Airlines Logo
11:00 am - 8:55 pm
MYR
-
SNA
12h 55m
2 stops
United Airlines Logo
6:39 pm - 10:18 am
SNA
-
MYR
12h 39m
2 stops
$435United Airlines
Tue, Apr 21 - Sun, Apr 26
United Airlines Logo
10:00 am - 5:18 pm
MYR
-
SNA
10h 18m
1 stop
United Airlines Logo
6:26 pm - 9:59 am
SNA
-
MYR
12h 33m
2 stops
$440United Airlines
Wed, Jun 3 - Wed, Jun 10

Spirit Airlines flights from Myrtle Beach to Santa Ana

Our best Spirit Airlines deals on Myrtle Beach to Santa Ana flight tickets
Spirit Airlines
Jun 3
MYR12:00 pmMyrtle Beach Intl
12h 45m
2 stops
SNA9:45 pmSanta Ana J. Wayne/Orange Cnty
Jun 10
SNA3:23 pmSanta Ana J. Wayne/Orange Cnty
16h 32m
2 stops
MYR10:55 amMyrtle Beach Intl
$382
Spirit Airlines
Jun 3
MYR12:00 pmMyrtle Beach Intl
12h 45m
2 stops
SNA9:45 pmSanta Ana J. Wayne/Orange Cnty
Jun 10
SNA3:23 pmSanta Ana J. Wayne/Orange Cnty
16h 32m
2 stops
MYR10:55 amMyrtle Beach Intl
$392
Spirit Airlines
May 19
MYR12:00 pmMyrtle Beach Intl
12h 45m
2 stops
SNA9:45 pmSanta Ana J. Wayne/Orange Cnty
Jun 4
SNA3:23 pmSanta Ana J. Wayne/Orange Cnty
16h 32m
2 stops
MYR10:55 amMyrtle Beach Intl
$394

American Airlines flights from Myrtle Beach to Santa Ana

Our best American Airlines deals on Myrtle Beach to Santa Ana flight tickets
American Airlines
Apr 18
MYR5:00 amMyrtle Beach Intl
11h 49m
2 stops
SNA1:49 pmSanta Ana J. Wayne/Orange Cnty
Apr 25
SNA8:17 amSanta Ana J. Wayne/Orange Cnty
11h 05m
2 stops
MYR10:22 pmMyrtle Beach Intl
$415
American Airlines
Apr 18
MYR1:55 pmMyrtle Beach Intl
10h 19m
1 stop
SNA9:14 pmSanta Ana J. Wayne/Orange Cnty
Apr 25
SNA8:17 amSanta Ana J. Wayne/Orange Cnty
11h 05m
2 stops
MYR10:22 pmMyrtle Beach Intl
$428
American Airlines
Sep 15
MYR4:15 pmMyrtle Beach Intl
6h 46m
1 stop
SNA8:01 pmSanta Ana J. Wayne/Orange Cnty
Sep 22
SNA7:58 amSanta Ana J. Wayne/Orange Cnty
8h 08m
1 stop
MYR7:06 pmMyrtle Beach Intl
$491

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Santa Ana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Wed 6/3

12:00 pm-9:45 pm

2 stops12h 45m

Santa Ana J. Wayne/Orange Cnty

Wed 6/10

3:23 pm-10:55 am

2 stops16h 32m

$382

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Wed 6/3

12:00 pm-9:45 pm

2 stops12h 45m

Santa Ana J. Wayne/Orange Cnty

Wed 6/10

3:23 pm-10:55 am

2 stops16h 32m

$392

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 5/19

12:00 pm-9:45 pm

2 stops12h 45m

Santa Ana J. Wayne/Orange Cnty

Thu 6/4

3:23 pm-10:55 am

2 stops16h 32m

$394

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Sat 4/18

5:00 am-1:49 pm

2 stops11h 49m

Santa Ana J. Wayne/Orange Cnty

Sat 4/25

8:17 am-10:22 pm

2 stops11h 05m

$415

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Wed 6/3

4:07 pm-10:29 pm

1 stop9h 22m

Santa Ana J. Wayne/Orange Cnty

Wed 6/10

7:15 pm-10:26 am

2 stops12h 11m

$426

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Sat 4/18

1:55 pm-9:14 pm

1 stop10h 19m

Santa Ana J. Wayne/Orange Cnty

Sat 4/25

8:17 am-10:22 pm

2 stops11h 05m

$428

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 4/21

3:15 pm-10:35 pm

1 stop10h 20m

Santa Ana J. Wayne/Orange Cnty

Sun 4/26

6:39 pm-10:18 am

2 stops12h 39m

$430
Quickest round-trip

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Sat 4/18

3:57 pm-8:57 pm

1 stop8h 00m

Santa Ana J. Wayne/Orange Cnty

Sat 4/25

1:11 pm-12:14 am

1 stop8h 03m

$432

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 4/21

11:00 am-8:55 pm

2 stops12h 55m

Santa Ana J. Wayne/Orange Cnty

Sun 4/26

6:39 pm-10:18 am

2 stops12h 39m

$435

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Wed 6/3

10:00 am-5:18 pm

1 stop10h 18m

Santa Ana J. Wayne/Orange Cnty

Wed 6/10

6:26 pm-9:59 am

2 stops12h 33m

$440

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Myrtle Beach to Santa Ana

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Myrtle Beach to Santa Ana flights?

You could potentially save up to 22% on your flight if you consider stops on a Myrtle Beach to Santa Ana flight.

When to book flights from Myrtle Beach to Santa Ana

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Santa Ana according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Santa Ana (MYR to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Santa Ana

Fastest flight time

9h 57m

Direct flights

None
The fastest flight from Myrtle Beach to Santa Ana takes 9h 57m
There are no direct flights from Myrtle Beach to Santa Ana. There are no popular flight routes from Myrtle Beach to Santa Ana.
Search flight deals

  • How far is Myrtle Beach Intl to Santa Ana J. Wayne/Orange Cnty by plane?

    Myrtle Beach Intl and Santa Ana J. Wayne/Orange Cnty are 2225.0 mi apart from one another. Typically, this will take 9h 57m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport refresh daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The required travel and health documents for your Santa Ana J. Wayne/Orange Cnty Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Ana J. Wayne/Orange Cnty Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to Santa Ana?

Best airlines flying from Myrtle Beach to Santa Ana

Compare and see reviews for airlines that fly from Myrtle Beach to Santa Ana with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $306Free CancellationRating
7.1
11,488 reviews
Search American Airlines flights

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Why should I use momondo to find a flight deal from Myrtle Beach to Santa Ana?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Myrtle Beach to Santa Ana. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Myrtle Beach to Santa Ana with flexible booking policies on momondo?

Flights from Myrtle Beach to Santa Ana with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Myrtle Beach to Santa Ana?

Once all potential Myrtle Beach to Santa Ana flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Santa Ana right now. Can momondo alert me if prices change?

Price alerts on flights to Santa Ana from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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