Cheap flights from Iowa to San Francisco from $114

If you aren’t able to travel to San Francisco during the month of February, then flying in May is also cheap. Prices for this month can be found on momondo for an average of $120.

You are more likely to see cheaper flights to San Francisco from Iowa when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $440 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Iowa for as low as $391 on momondo.

Frontier, Delta, and Southwest are the most popular carriers operating from Iowa to San Francisco

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to San Francisco from Iowa according to our data. American Airlines is the first choice among our users, with 41% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 5 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

As of May 2026, 6 flights take off from Iowa and land in San Francisco each week. The most common flight departure day for this route is Mon, with 33% of weekly flights taking off on this day.

Flight times from Iowa to San Francisco vary, but if you’re flying out of Cedar Rapids and flying into San Francisco (one of the most popular routes), then the duration is 5h 48m on average. Another popular route from Iowa to San Francisco is flying from Des Moines to San Francisco, which will take roughly 6h 21m. Keep in mind that layovers or delays could extend your travel time.