Cheap flights from Indianapolis to San Francisco from $138

If you aren’t able to travel to San Francisco during the month of September, then flying in April is also cheap. Prices for this month can be found on momondo for an average of $381.

The cheapest day to depart from Indianapolis to San Francisco is on a Friday when prices can be found for as low as $440. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $732.

Our data shows that the cheapest Indianapolis to San Francisco flights are usually those with departure times in the afternoon. Our users have found flights to San Francisco in the afternoon for as low as $487. Flights in the evening are often more expensive with an average ticket price of $1,016.

Fly from Indianapolis to San Francisco for the best Indianapolis - San Francisco flight prices

You are more likely to see cheaper flights to San Francisco from Indianapolis when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $407 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Indianapolis for as low as $308 on momondo.

There are 4 cabin classes available to choose from on Indianapolis to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 8% on your flight if you consider stops on a Indianapolis to San Francisco flight.

As of August 2026, prices for Indianapolis to San Francisco flights are approximately 8% more expensive when compared to flights at the same time last year.

Alaska Airlines, Southwest, and United Airlines are the most popular carriers operating from Indianapolis to San Francisco

United Airlines, Delta and Southwest are the top three most popular airlines that fly to San Francisco from Indianapolis according to our data. United Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 7 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

Denver (DEN) was the most common stop: 78% of momondo users choosing 1-stop flights on this route connected there.

Flights via Denver (DEN) offer the lowest average round-trip price of $402.

Flights connecting via Denver (DEN) have the shortest average one-way travel time: 7h 18m.

Chicago (ORD) has the shortest average layover time for this route: 1h 32m.