Cheap flights from Indiana to San Diego from $105

If you are unable to visit San Diego during the month of November, then departing from Indiana during the month October is also very affordable. Most momondo users find prices during this month for around $86.

The cheapest day to depart from Indiana to San Diego is on a Saturday. Travelers who choose to depart for San Diego on a Saturday will often find tickets for as low as $427. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $589. These prices are subject to change though, so be sure to set up a Price Alert for flights to San Diego.

The cheapest time of day to fly to San Diego is in the afternoon when flights can be purchased for as low as $484. Flights in the evening are often more expensive with an average ticket price of $573.

Fly from Indianapolis to San Diego for the best Indiana - San Diego flight prices

You are more likely to see cheaper flights to San Diego from Indiana when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $374 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Indiana for as low as $303 on momondo.

United Airlines, Frontier, and Delta are the most popular carriers operating from Indiana to San Diego

American Airlines, Southwest and United Airlines are the top three most popular airlines that fly to San Diego from Indiana according to our data. American Airlines is the first choice among our users, with 38% of people opting to fly with this airline when traveling to San Diego. Keep in mind that there are 6 different airlines that fly to San Diego on a routine basis, so you have a few additional options to choose from.

As of May 2026, there are 34 flights per day flying from Indiana to San Diego. The most common time of day flights depart is 1:00PM, with 100% of flights taking off in the afternoon.

244 flights are operational weekly from Indiana to San Diego as of May 2026. The most popular departure day for this route is Fri, with 20% of flights per week taking off on this day.