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Cheap flights from Greenville to San Diego from $170

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to San Diego departing on 8/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Greenville to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:57 am - 1:13 pm
GSP
-
SAN
9h 16m
1 stop
American Airlines Logo
6:15 am - 4:21 pm
SAN
-
GSP
7h 06m
1 stop
$383American Airlines
Tue, Apr 28 - Tue, May 12
United Airlines Logo
7:00 am - 11:03 am
GSP
-
SAN
7h 03m
1 stop
United Airlines Logo
10:55 am - 10:58 pm
SAN
-
GSP
9h 03m
2 stops
$388United Airlines
Wed, May 6 - Wed, May 13
American Airlines Logo
6:31 am - 12:14 pm
GSP
-
SAN
8h 43m
1 stop
American Airlines Logo
9:54 am - 7:24 pm
SAN
-
GSP
6h 30m
1 stop
$391American Airlines
Sat, May 9 - Wed, May 27
United Airlines Logo
5:10 pm - 9:24 pm
GSP
-
SAN
7h 14m
1 stop
United Airlines Logo
8:32 pm - 9:55 am
SAN
-
GSP
10h 23m
2 stops
$396United Airlines
Sat, May 23 - Tue, May 26
American Airlines Logo
5:12 pm - 10:00 pm
GSP
-
SAN
7h 48m
1 stop
American Airlines Logo
9:45 pm - 9:51 am
SAN
-
GSP
9h 06m
1 stop
$399American Airlines
Thu, May 14 - Mon, May 18
Southwest Logo
6:25 pm - 10:55 pm
GSP
-
SAN
7h 30m
1 stop
Southwest Logo
6:45 am - 9:40 pm
SAN
-
GSP
11h 55m
2 stops
$402Southwest
Mon, Apr 27 - Wed, Apr 29
American Airlines Logo
6:41 pm - 11:39 pm
GSP
-
SAN
7h 58m
1 stop
American Airlines Logo
10:28 pm - 10:08 am
SAN
-
GSP
8h 40m
1 stop
$403American Airlines
Wed, Jun 24 - Tue, Jun 30
Southwest Logo
12:35 pm - 9:05 pm
GSP
-
SAN
11h 30m
2 stops
Southwest Logo
10:40 pm - 12:10 pm
SAN
-
GSP
10h 30m
1 stop
$410Southwest
Thu, May 14 - Mon, May 18
American Airlines Logo
8:02 am - 1:14 pm
GSP
-
SAN
8h 12m
1 stop
American Airlines Logo
12:17 pm - 10:40 pm
SAN
-
GSP
7h 23m
1 stop
$425American Airlines
Fri, May 8 - Tue, May 12
Southwest Logo
6:25 am - 12:40 pm
GSP
-
SAN
9h 15m
2 stops
Southwest Logo
6:45 am - 9:40 pm
SAN
-
GSP
11h 55m
2 stops
$427Southwest
Mon, Apr 27 - Wed, Apr 29

American Airlines flights from Greenville to San Diego

Our best American Airlines deals on Greenville to San Diego flight tickets
American Airlines
Apr 28
GSP6:57 amGreenville
9h 16m
1 stop
SAN1:13 pmSan Diego
May 12
SAN6:15 amSan Diego
7h 06m
1 stop
GSP4:21 pmGreenville
$383
American Airlines
May 9
GSP6:31 amGreenville
8h 43m
1 stop
SAN12:14 pmSan Diego
May 27
SAN9:54 amSan Diego
6h 30m
1 stop
GSP7:24 pmGreenville
$391
American Airlines
May 14
GSP5:12 pmGreenville
7h 48m
1 stop
SAN10:00 pmSan Diego
May 18
SAN9:45 pmSan Diego
9h 06m
1 stop
GSP9:51 amGreenville
$399

United Airlines flights from Greenville to San Diego

Our best United Airlines deals on Greenville to San Diego flight tickets
United Airlines
May 6
GSP7:00 amGreenville
7h 03m
1 stop
SAN11:03 amSan Diego
May 13
SAN10:55 amSan Diego
9h 03m
2 stops
GSP10:58 pmGreenville
$388
United Airlines
May 23
GSP5:10 pmGreenville
7h 14m
1 stop
SAN9:24 pmSan Diego
May 26
SAN8:32 pmSan Diego
10h 23m
2 stops
GSP9:55 amGreenville
$396
United Airlines
Jun 24
GSP5:41 pmGreenville
7h 53m
1 stop
SAN10:34 pmSan Diego
Jul 1
SAN10:40 pmSan Diego
8h 34m
1 stop
GSP10:14 amGreenville
$446

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 5, 2026.
Use the filters below to find and compare flights from Greenville to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Tue 4/28

6:57 am-1:13 pm

1 stop9h 16m

San Diego

Tue 5/12

6:15 am-4:21 pm

1 stop7h 06m

$383

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Wed 5/6

7:00 am-11:03 am

1 stop7h 03m

San Diego

Wed 5/13

10:55 am-10:58 pm

2 stops9h 03m

$388
Quickest round-trip

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Sat 5/9

6:31 am-12:14 pm

1 stop8h 43m

San Diego

Wed 5/27

9:54 am-7:24 pm

1 stop6h 30m

$391

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Sat 5/23

5:10 pm-9:24 pm

1 stop7h 14m

San Diego

Tue 5/26

8:32 pm-9:55 am

2 stops10h 23m

$396

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Thu 5/14

5:12 pm-10:00 pm

1 stop7h 48m

San Diego

Mon 5/18

9:45 pm-9:51 am

1 stop9h 06m

$399

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Mon 4/27

6:25 pm-10:55 pm

1 stop7h 30m

San Diego

Wed 4/29

6:45 am-9:40 pm

2 stops11h 55m

$402

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Wed 6/24

6:41 pm-11:39 pm

1 stop7h 58m

San Diego

Tue 6/30

10:28 pm-10:08 am

1 stop8h 40m

$403

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Thu 5/14

12:35 pm-9:05 pm

2 stops11h 30m

San Diego

Mon 5/18

10:40 pm-12:10 pm

1 stop10h 30m

$410

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Fri 5/8

8:02 am-1:14 pm

1 stop8h 12m

San Diego

Tue 5/12

12:17 pm-10:40 pm

1 stop7h 23m

$425

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Mon 4/27

6:25 am-12:40 pm

2 stops9h 15m

San Diego

Wed 4/29

6:45 am-9:40 pm

2 stops11h 55m

$427

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from Greenville to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Greenville and San Diego?

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of January, then departing from Greenville during the month October is also very affordable. Most momondo users find prices during this month for around $386.

How far in advance should I book a flight to San Diego?

You are more likely to see cheaper flights to San Diego from Greenville when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $461 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from Greenville for as low as $346 on momondo.

How have Greenville to San Diego flight prices changed over time?

As of April 2026, prices for Greenville to San Diego flights are approximately 1% cheaper when compared to flights at the same time last year.

When to book flights from Greenville to San Diego

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to San Diego according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to San Diego (GSP to SAN) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to San Diego

Fastest flight time

6h 10m

Direct flights

None
The fastest flight from Greenville to San Diego takes 6h 10m
There are no direct flights from Greenville to San Diego. There are no popular flight routes from Greenville to San Diego.
Search flight deals

Frequently asked questions about flying from Greenville to San Diego

  • How far is Greenville to San Diego by plane?

    A flight from Greenville to San Diego will travel around 1990.4 mi. By plane, this route typically takes 6h 10m.

  • When did momondo last update prices for flights from Greenville Airport to San Diego Airport?

    Prices for flights from Greenville Airport to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from Greenville Airport to San Diego Airport?

  • How old do you have to be to fly from Greenville Airport to San Diego Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Greenville Airport to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The necessary travel and health documents for your San Diego Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to San Diego?

Best airlines flying from Greenville to San Diego

Compare and see reviews for airlines that fly from Greenville to San Diego with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $148Free CancellationRating
7.9
8,386 reviews
Search Delta flights
SouthwestPriceFrom $305Free CancellationRating
8.0
4,341 reviews
Search Southwest flights
United AirlinesPriceFrom $312Free CancellationRating
7.4
9,545 reviews
Search United Airlines flights
American AirlinesPriceFrom $312Free CancellationRating
7.1
11,555 reviews
Search American Airlines flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Coronado
Chula Vista
El Cajon
Julian
National City
Poway
San Ysidro
Imperial Beach
La Mesa
Lemon Grove
Borrego Springs
Alpine
Santee

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to San Diego?

Finding the right flight to San Diego from Greenville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to San Diego quick and easy, saving you time and money.

Can I find flights from Greenville to San Diego with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Diego from Greenville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Greenville to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from Greenville.

I’m not ready to book a flight from Greenville to San Diego right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Diego, momondo offers a useful price alert feature which will track prices for flights to San Diego from Greenville and alert you when they change.

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