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Cheap flights from Florence, South Carolina to San Francisco from $557

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to San Francisco departing on 2/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florence, South Carolina to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:15 am - 1:50 pm
FLO
-
SFO
10h 35m
1 stop
American Airlines Logo
7:00 am - 5:50 pm
SFO
-
FLO
7h 50m
1 stop
$557American Airlines
Wed, Feb 11 - Sun, Feb 15
American Airlines Logo
6:15 am - 4:34 pm
FLO
-
SFO
13h 19m
2 stops
American Airlines Logo
1:17 pm - 11:57 pm
SFO
-
FLO
7h 40m
1 stop
$562American Airlines
Wed, Feb 11 - Sun, Feb 15
American Airlines Logo
5:16 am - 1:37 pm
FLO
-
SFO
11h 21m
2 stops
American Airlines Logo
11:35 pm - 5:21 pm
SFO
-
FLO
14h 46m
2 stops
$567American Airlines
Thu, Feb 12 - Mon, Feb 16
American Airlines Logo
6:15 am - 5:24 pm
FLO
-
SFO
14h 09m
2 stops
American Airlines Logo
9:25 am - 11:57 pm
SFO
-
FLO
11h 32m
2 stops
$644American Airlines
Wed, Feb 11 - Sun, Feb 15
American Airlines Logo
5:36 pm - 10:28 pm
FLO
-
SFO
7h 52m
1 stop
American Airlines Logo
7:00 am - 5:50 pm
SFO
-
FLO
7h 50m
1 stop
$720American Airlines
Sun, Feb 8 - Sun, Feb 15
American Airlines Logo
6:15 am - 4:01 pm
FLO
-
SFO
12h 46m
2 stops
American Airlines Logo
1:17 pm - 11:57 pm
SFO
-
FLO
7h 40m
1 stop
$725American Airlines
Sun, Feb 8 - Sat, Feb 14
American Airlines Logo
6:15 am - 3:05 pm
FLO
-
SFO
11h 50m
2 stops
American Airlines Logo
7:00 am - 5:50 pm
SFO
-
FLO
7h 50m
1 stop
$748American Airlines
Sun, Feb 8 - Sun, Feb 15
American Airlines Logo
5:36 pm - 10:28 pm
FLO
-
SFO
7h 52m
1 stop
American Airlines Logo
7:00 am - 5:09 pm
SFO
-
FLO
7h 09m
1 stop
$750American Airlines
Sun, Feb 8 - Wed, Feb 11
American Airlines Logo
6:15 am - 6:30 pm
FLO
-
SFO
15h 15m
2 stops
American Airlines Logo
6:00 am - 5:50 pm
SFO
-
FLO
8h 50m
2 stops
$753American Airlines
Sun, Feb 8 - Sat, Feb 14
American Airlines Logo
6:15 am - 4:01 pm
FLO
-
SFO
12h 46m
2 stops
American Airlines Logo
1:17 pm - 11:57 pm
SFO
-
FLO
7h 40m
1 stop
$755American Airlines
Sun, Feb 8 - Fri, Feb 13

American Airlines flights from Florence, South Carolina to San Francisco

Our best American Airlines deals on Florence, South Carolina to San Francisco flight tickets
American Airlines
Feb 11
FLO6:15 amFlorence
10h 35m
1 stop
SFO1:50 pmSan Francisco
Feb 15
SFO7:00 amSan Francisco
7h 50m
1 stop
FLO5:50 pmFlorence
$557
American Airlines
Feb 11
FLO6:15 amFlorence
13h 19m
2 stops
SFO4:34 pmSan Francisco
Feb 15
SFO1:17 pmSan Francisco
7h 40m
1 stop
FLO11:57 pmFlorence
$562
American Airlines
Feb 12
FLO5:16 amFlorence
11h 21m
2 stops
SFO1:37 pmSan Francisco
Feb 16
SFO11:35 pmSan Francisco
14h 46m
2 stops
FLO5:21 pmFlorence
$567

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 2/11

6:15 am-1:50 pm

1 stop10h 35m

San Francisco

Sun 2/15

7:00 am-5:50 pm

1 stop7h 50m

$557

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 2/11

6:15 am-4:34 pm

2 stops13h 19m

San Francisco

Sun 2/15

1:17 pm-11:57 pm

1 stop7h 40m

$562

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Thu 2/12

5:16 am-1:37 pm

2 stops11h 21m

San Francisco

Mon 2/16

11:35 pm-5:21 pm

2 stops14h 46m

$567

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 2/11

6:15 am-5:24 pm

2 stops14h 09m

San Francisco

Sun 2/15

9:25 am-11:57 pm

2 stops11h 32m

$644

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 2/8

5:36 pm-10:28 pm

1 stop7h 52m

San Francisco

Sun 2/15

7:00 am-5:50 pm

1 stop7h 50m

$720

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 2/8

6:15 am-4:01 pm

2 stops12h 46m

San Francisco

Sat 2/14

1:17 pm-11:57 pm

1 stop7h 40m

$725

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 2/8

6:15 am-3:05 pm

2 stops11h 50m

San Francisco

Sun 2/15

7:00 am-5:50 pm

1 stop7h 50m

$748

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 2/8

5:36 pm-10:28 pm

1 stop7h 52m

San Francisco

Wed 2/11

7:00 am-5:09 pm

1 stop7h 09m

$750

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 2/8

6:15 am-6:30 pm

2 stops15h 15m

San Francisco

Sat 2/14

6:00 am-5:50 pm

2 stops8h 50m

$753

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 2/8

6:15 am-4:01 pm

2 stops12h 46m

San Francisco

Fri 2/13

1:17 pm-11:57 pm

1 stop7h 40m

$755

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

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How to get the cheapest flight ticket from Florence, South Carolina to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to San Francisco?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to San Francisco from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 71% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 7 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to San Francisco (FLO to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to San Francisco

Fastest flight time

7h 50m

Direct flights

None
The fastest flight from Florence, South Carolina to San Francisco takes 7h 50m
There are no direct flights from Florence, South Carolina to San Francisco. There are no popular flight routes from Florence, South Carolina to San Francisco.
Search flight deals

  • How far is Florence to San Francisco by plane?

    The distance between Florence and San Francisco is about 2374.9 mi. In terms of flight time, this usually takes a little over 7h 50m.

  • When did momondo last update prices for flights from Florence Airport to San Francisco Airport?

    Prices for flights from Florence Airport to San Francisco Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Florence Airport to San Francisco Airport?

  • How old do you have to be to fly from Florence Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Florence, South Carolina to San Francisco?

Best airlines flying from Florence, South Carolina to San Francisco

Compare and see reviews for airlines that fly from Florence, South Carolina to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $326Free CancellationRating
7.2
11,206 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Santa Clara
Berkeley
Walnut Creek
Fremont
Daly City
Half Moon Bay
Salinas
Vallejo
Livermore
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Florence to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Florence to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Florence to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Florence which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Florence to San Francisco?

Once you have performed a search for Florence to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Florence to San Francisco right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Francisco, momondo offers a useful price alert feature which will track prices for flights to San Francisco from Florence and alert you when they change.

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