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Cheap flights from Florence, South Carolina to San Francisco from $199

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to San Francisco departing on 5/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florence, South Carolina to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:16 pm - 11:15 pm
FLO
-
SFO
9h 59m
1 stop
American Airlines Logo
9:08 am - 9:47 pm
SFO
-
FLO
9h 39m
1 stop
$517American Airlines
Mon, Apr 13 - Fri, Apr 17
American Airlines Logo
4:16 pm - 11:15 pm
FLO
-
SFO
9h 59m
1 stop
American Airlines Logo
8:00 am - 9:47 pm
SFO
-
FLO
10h 47m
2 stops
$522American Airlines
Mon, Apr 13 - Fri, Apr 17
American Airlines Logo
6:25 pm - 11:10 pm
FLO
-
SFO
7h 45m
1 stop
American Airlines Logo
9:08 am - 9:47 pm
SFO
-
FLO
9h 39m
1 stop
$577American Airlines
Sat, Apr 4 - Wed, Apr 8
American Airlines Logo
6:20 pm - 11:10 pm
FLO
-
SFO
7h 50m
1 stop
American Airlines Logo
12:59 am - 3:32 pm
SFO
-
FLO
11h 33m
2 stops
$582American Airlines
Fri, Apr 3 - Mon, Apr 6
American Airlines Logo
2:34 pm - 8:29 pm
FLO
-
SFO
8h 55m
1 stop
American Airlines Logo
11:30 pm - 10:50 am
SFO
-
FLO
8h 20m
1 stop
$589American Airlines
Fri, Aug 14 - Fri, Aug 21
American Airlines Logo
11:15 am - 5:53 pm
FLO
-
SFO
9h 38m
2 stops
American Airlines Logo
11:30 pm - 10:50 am
SFO
-
FLO
8h 20m
1 stop
$595American Airlines
Fri, Aug 14 - Fri, Aug 21
American Airlines Logo
11:15 am - 7:16 pm
FLO
-
SFO
11h 01m
2 stops
American Airlines Logo
7:54 pm - 10:50 am
SFO
-
FLO
11h 56m
2 stops
$600American Airlines
Fri, Aug 14 - Fri, Aug 21
American Airlines Logo
5:16 am - 3:45 pm
FLO
-
SFO
13h 29m
2 stops
American Airlines Logo
11:59 pm - 3:50 pm
SFO
-
FLO
12h 51m
2 stops
$694American Airlines
Sat, Apr 4 - Wed, Apr 8
American Airlines Logo
5:16 am - 5:19 pm
FLO
-
SFO
15h 03m
2 stops
American Airlines Logo
12:59 am - 3:32 pm
SFO
-
FLO
11h 33m
2 stops
$738American Airlines
Fri, Apr 3 - Mon, Apr 6
American Airlines Logo
6:20 pm - 11:10 pm
FLO
-
SFO
7h 50m
1 stop
American Airlines Logo
5:30 am - 9:47 pm
SFO
-
FLO
13h 17m
2 stops
$794American Airlines
Mon, Apr 6 - Fri, Apr 10

American Airlines flights from Florence, South Carolina to San Francisco

Our best American Airlines deals on Florence, South Carolina to San Francisco flight tickets
American Airlines
Apr 13
FLO4:16 pmFlorence
9h 59m
1 stop
SFO11:15 pmSan Francisco
Apr 17
SFO9:08 amSan Francisco
9h 39m
1 stop
FLO9:47 pmFlorence
$517
American Airlines
Apr 13
FLO4:16 pmFlorence
9h 59m
1 stop
SFO11:15 pmSan Francisco
Apr 17
SFO8:00 amSan Francisco
10h 47m
2 stops
FLO9:47 pmFlorence
$522
American Airlines
Apr 4
FLO6:25 pmFlorence
7h 45m
1 stop
SFO11:10 pmSan Francisco
Apr 8
SFO9:08 amSan Francisco
9h 39m
1 stop
FLO9:47 pmFlorence
$577

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 4/13

4:16 pm-11:15 pm

1 stop9h 59m

San Francisco

Fri 4/17

9:08 am-9:47 pm

1 stop9h 39m

$517

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 4/13

4:16 pm-11:15 pm

1 stop9h 59m

San Francisco

Fri 4/17

8:00 am-9:47 pm

2 stops10h 47m

$522

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sat 4/4

6:25 pm-11:10 pm

1 stop7h 45m

San Francisco

Wed 4/8

9:08 am-9:47 pm

1 stop9h 39m

$577

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 4/3

6:20 pm-11:10 pm

1 stop7h 50m

San Francisco

Mon 4/6

12:59 am-3:32 pm

2 stops11h 33m

$582
Quickest round-trip

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 8/14

2:34 pm-8:29 pm

1 stop8h 55m

San Francisco

Fri 8/21

11:30 pm-10:50 am

1 stop8h 20m

$589

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 8/14

11:15 am-5:53 pm

2 stops9h 38m

San Francisco

Fri 8/21

11:30 pm-10:50 am

1 stop8h 20m

$595

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 8/14

11:15 am-7:16 pm

2 stops11h 01m

San Francisco

Fri 8/21

7:54 pm-10:50 am

2 stops11h 56m

$600

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sat 4/4

5:16 am-3:45 pm

2 stops13h 29m

San Francisco

Wed 4/8

11:59 pm-3:50 pm

2 stops12h 51m

$694

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 4/3

5:16 am-5:19 pm

2 stops15h 03m

San Francisco

Mon 4/6

12:59 am-3:32 pm

2 stops11h 33m

$738

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 4/6

6:20 pm-11:10 pm

1 stop7h 50m

San Francisco

Fri 4/10

5:30 am-9:47 pm

2 stops13h 17m

$794

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Florence, South Carolina to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Florence to San Francisco?

American Airlines is the most popular carrier operating from Florence to San Francisco

What airlines fly to San Francisco?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to San Francisco from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 69% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 7 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to San Francisco (FLO to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to San Francisco

Fastest flight time

7h 45m

Direct flights

None
The fastest flight from Florence, South Carolina to San Francisco takes 7h 45m
There are no direct flights from Florence, South Carolina to San Francisco. There are no popular flight routes from Florence, South Carolina to San Francisco.
Search flight deals

  • How far is Florence to San Francisco by plane?

    The distance between Florence and San Francisco is about 2374.9 mi. In terms of flight time, this usually takes a little over 7h 45m.

  • When did momondo last update prices for flights from Florence Airport to San Francisco Airport?

    Prices for flights from Florence Airport to San Francisco Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Florence Airport to San Francisco Airport?

  • How old do you have to be to fly from Florence Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Florence, South Carolina to San Francisco?

Best airlines flying from Florence, South Carolina to San Francisco

Compare and see reviews for airlines that fly from Florence, South Carolina to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $412Free CancellationRating
7.1
11,489 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Walnut Creek
Roseville
Hayward
Berkeley
Santa Clara
Big Sur
Fremont
Calistoga
Vallejo
Salinas
Half Moon Bay
Daly City
Milpitas
Pacific Grove
South San Francisco

Why use momondo?

Why should I use momondo to find a flight deal from Florence to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Florence to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Florence to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Florence which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Florence to San Francisco?

Once you have performed a search for Florence to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Florence to San Francisco right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Francisco, momondo offers a useful price alert feature which will track prices for flights to San Francisco from Florence and alert you when they change.

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