Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Florence, South Carolina to San Francisco from $582

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to San Francisco departing on 5/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Florence, South Carolina to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:05 am - 12:17 pm
FLO
-
SFO
10h 12m
1 stop
American Airlines Logo
11:29 pm - 2:10 pm
SFO
-
FLO
11h 41m
2 stops
$582American Airlines
Sun, May 24 - Thu, May 28
American Airlines Logo
5:05 am - 3:03 pm
FLO
-
SFO
12h 58m
2 stops
American Airlines Logo
5:23 am - 10:00 pm
SFO
-
FLO
13h 37m
2 stops
$587American Airlines
Sun, May 24 - Thu, May 28
American Airlines Logo
5:05 am - 12:17 pm
FLO
-
SFO
10h 12m
1 stop
American Airlines Logo
5:23 am - 10:00 pm
SFO
-
FLO
13h 37m
2 stops
$629American Airlines
Wed, May 27 - Sun, May 31
American Airlines Logo
2:35 pm - 12:09 am
FLO
-
SFO
12h 34m
2 stops
American Airlines Logo
11:29 pm - 2:10 pm
SFO
-
FLO
11h 41m
2 stops
$635American Airlines
Wed, May 27 - Sun, May 31
American Airlines Logo
2:35 pm - 8:00 pm
FLO
-
SFO
8h 25m
1 stop
American Airlines Logo
11:29 pm - 2:10 pm
SFO
-
FLO
11h 41m
2 stops
$773American Airlines
Mon, Jun 8 - Sun, Jun 14
American Airlines Logo
5:05 am - 1:04 pm
FLO
-
SFO
10h 59m
2 stops
American Airlines Logo
11:29 pm - 2:10 pm
SFO
-
FLO
11h 41m
2 stops
$778American Airlines
Mon, Jun 8 - Sun, Jun 14
American Airlines Logo
5:05 am - 8:00 pm
FLO
-
SFO
17h 55m
1 stop
American Airlines Logo
11:49 pm - 10:00 pm
SFO
-
FLO
19h 11m
1 stop
$930American Airlines
Wed, May 27 - Sun, May 31
American Airlines Logo
2:35 pm - 8:00 pm
FLO
-
SFO
8h 25m
1 stop
American Airlines Logo
5:00 am - 10:00 pm
SFO
-
FLO
14h 00m
1 stop
$999American Airlines
Mon, Jun 8 - Sun, Jun 14
American Airlines Logo
2:35 pm - 9:19 pm
FLO
-
SFO
9h 44m
1 stop
American Airlines Logo
8:15 am - 10:00 pm
SFO
-
FLO
10h 45m
1 stop
$1,320American Airlines
Sun, May 24 - Thu, May 28

American Airlines flights from Florence, South Carolina to San Francisco

Our best American Airlines deals on Florence, South Carolina to San Francisco flight tickets
American Airlines
May 24
FLO5:05 amFlorence
10h 12m
1 stop
SFO12:17 pmSan Francisco
May 28
SFO11:29 pmSan Francisco
11h 41m
2 stops
FLO2:10 pmFlorence
$582
American Airlines
May 24
FLO5:05 amFlorence
12h 58m
2 stops
SFO3:03 pmSan Francisco
May 28
SFO5:23 amSan Francisco
13h 37m
2 stops
FLO10:00 pmFlorence
$587
American Airlines
May 27
FLO5:05 amFlorence
10h 12m
1 stop
SFO12:17 pmSan Francisco
May 31
SFO5:23 amSan Francisco
13h 37m
2 stops
FLO10:00 pmFlorence
$629

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 5/24

5:05 am-12:17 pm

1 stop10h 12m

San Francisco

Thu 5/28

11:29 pm-2:10 pm

2 stops11h 41m

$582

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 5/24

5:05 am-3:03 pm

2 stops12h 58m

San Francisco

Thu 5/28

5:23 am-10:00 pm

2 stops13h 37m

$587

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 5/27

5:05 am-12:17 pm

1 stop10h 12m

San Francisco

Sun 5/31

5:23 am-10:00 pm

2 stops13h 37m

$629

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 5/27

2:35 pm-12:09 am

2 stops12h 34m

San Francisco

Sun 5/31

11:29 pm-2:10 pm

2 stops11h 41m

$635
Quickest round-trip

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 6/8

2:35 pm-8:00 pm

1 stop8h 25m

San Francisco

Sun 6/14

11:29 pm-2:10 pm

2 stops11h 41m

$773

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 6/8

5:05 am-1:04 pm

2 stops10h 59m

San Francisco

Sun 6/14

11:29 pm-2:10 pm

2 stops11h 41m

$778

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 5/27

5:05 am-8:00 pm

1 stop17h 55m

San Francisco

Sun 5/31

11:49 pm-10:00 pm

1 stop19h 11m

$930

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 6/8

2:35 pm-8:00 pm

1 stop8h 25m

San Francisco

Sun 6/14

5:00 am-10:00 pm

1 stop14h 00m

$999

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 5/24

2:35 pm-9:19 pm

1 stop9h 44m

San Francisco

Thu 5/28

8:15 am-10:00 pm

1 stop10h 45m

$1,320

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to San Francisco from

How to get the cheapest flight ticket from Florence, South Carolina to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to San Francisco?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to San Francisco from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 69% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 7 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to San Francisco (FLO to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to San Francisco

Fastest flight time

8h 25m

Direct flights

None
The fastest flight from Florence, South Carolina to San Francisco takes 8h 25m
There are no direct flights from Florence, South Carolina to San Francisco. There are no popular flight routes from Florence, South Carolina to San Francisco.
Search flight deals

Frequently asked questions about flying from Florence, South Carolina to San Francisco

  • How far is Florence to San Francisco by plane?

    The distance between Florence and San Francisco is about 2374.4 mi. In terms of flight time, this usually takes a little over 8h 25m.

  • When did momondo last update prices for flights from Florence Airport to San Francisco Airport?

    Prices for flights from Florence Airport to San Francisco Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Florence Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Walnut Creek
Bodega Bay
Hayward
Roseville
Santa Clara
Berkeley
Fremont
Vallejo
Big Sur
Sunnyvale
Calistoga
South San Francisco
Salinas
Daly City
Milpitas
Pacific Grove

Why use momondo?

Why should I use momondo to find a flight deal from Florence to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Florence to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Florence to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Florence which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Florence to San Francisco?

Once you have performed a search for Florence to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Florence to San Francisco right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Francisco, momondo offers a useful price alert feature which will track prices for flights to San Francisco from Florence and alert you when they change.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Fri 6/12
Fri 6/19
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States