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Cheap flights from Florence, South Carolina to San Francisco from $688

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to San Francisco departing on 12/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florence, South Carolina to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:30 pm - 11:07 pm
FLO
-
SFO
7h 37m1 stop
American Airlines Logo
12:22 am - 12:42 pm
SFO
-
FLO
9h 20m1 stop
$688American Airlines
Mon, Dec 29 - Thu, Jan 1
American Airlines Logo
6:30 pm - 11:07 pm
FLO
-
SFO
7h 37m1 stop
American Airlines Logo
7:00 am - 6:05 pm
SFO
-
FLO
8h 05m1 stop
$731American Airlines
Tue, Dec 30 - Sat, Jan 3
American Airlines Logo
5:15 am - 3:58 pm
FLO
-
SFO
13h 43m2 stops
American Airlines Logo
12:22 am - 12:42 pm
SFO
-
FLO
9h 20m1 stop
$855American Airlines
Mon, Dec 29 - Thu, Jan 1
American Airlines Logo
5:15 am - 12:23 pm
FLO
-
SFO
10h 08m1 stop
American Airlines Logo
12:22 am - 12:26 pm
SFO
-
FLO
9h 04m1 stop
$872American Airlines
Sun, Dec 28 - Wed, Dec 31
American Airlines Logo
6:30 pm - 11:07 pm
FLO
-
SFO
7h 37m1 stop
American Airlines Logo
9:15 am - 12:15 am
SFO
-
FLO
12h 00m2 stops
$878American Airlines
Tue, Dec 30 - Sat, Jan 3
American Airlines Logo
5:15 am - 12:23 pm
FLO
-
SFO
10h 08m1 stop
American Airlines Logo
8:00 am - 12:15 am
SFO
-
FLO
13h 15m2 stops
$914American Airlines
Sun, Dec 28 - Thu, Jan 1
American Airlines Logo
12:51 pm - 7:18 pm
FLO
-
SFO
9h 27m2 stops
American Airlines Logo
7:00 am - 12:15 am
SFO
-
FLO
14h 15m2 stops
$925American Airlines
Tue, Dec 30 - Sat, Jan 3
American Airlines Logo
5:15 am - 1:13 pm
FLO
-
SFO
10h 58m2 stops
American Airlines Logo
9:15 am - 12:15 am
SFO
-
FLO
12h 00m2 stops
$1,015American Airlines
Sun, Dec 28 - Thu, Jan 1
American Airlines Logo
12:51 pm - 9:02 pm
FLO
-
SFO
11h 11m2 stops
American Airlines Logo
11:59 pm - 12:42 pm
SFO
-
FLO
9h 43m2 stops
$1,053American Airlines
Mon, Dec 29 - Fri, Jan 2

American Airlines flights from Florence, South Carolina to San Francisco

Our best American Airlines deals on Florence, South Carolina to San Francisco flight tickets
American Airlines
Dec 31
FLO5:15 amFlorence
10h 08m
1 stop
SFO12:23 pmSan Francisco
Jan 4
SFO1:31 pmSan Francisco
7h 44m
1 stop
FLO12:15 amFlorence
$682
Find similar
American Airlines
Dec 29
FLO6:30 pmFlorence
7h 37m
1 stop
SFO11:07 pmSan Francisco
Jan 1
SFO12:22 amSan Francisco
9h 20m
1 stop
FLO12:42 pmFlorence
$688
Find similar
American Airlines
Dec 31
FLO5:15 amFlorence
10h 58m
2 stops
SFO1:13 pmSan Francisco
Jan 4
SFO1:31 pmSan Francisco
7h 44m
1 stop
FLO12:15 amFlorence
$715
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Florence, South Carolina to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 12/29

6:30 pm-11:07 pm

1 stop7h 37m

San Francisco

Thu 1/1

12:22 am-12:42 pm

1 stop9h 20m

$688

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Tue 12/30

6:30 pm-11:07 pm

1 stop7h 37m

San Francisco

Sat 1/3

7:00 am-6:05 pm

1 stop8h 05m

$731

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 12/29

5:15 am-3:58 pm

2 stops13h 43m

San Francisco

Thu 1/1

12:22 am-12:42 pm

1 stop9h 20m

$855

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 12/28

5:15 am-12:23 pm

1 stop10h 08m

San Francisco

Wed 12/31

12:22 am-12:26 pm

1 stop9h 04m

$872

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Tue 12/30

6:30 pm-11:07 pm

1 stop7h 37m

San Francisco

Sat 1/3

9:15 am-12:15 am

2 stops12h 00m

$878

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 12/28

5:15 am-12:23 pm

1 stop10h 08m

San Francisco

Thu 1/1

8:00 am-12:15 am

2 stops13h 15m

$914

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Tue 12/30

12:51 pm-7:18 pm

2 stops9h 27m

San Francisco

Sat 1/3

7:00 am-12:15 am

2 stops14h 15m

$925

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 12/28

5:15 am-1:13 pm

2 stops10h 58m

San Francisco

Thu 1/1

9:15 am-12:15 am

2 stops12h 00m

$1,015

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 12/29

12:51 pm-9:02 pm

2 stops11h 11m

San Francisco

Fri 1/2

11:59 pm-12:42 pm

2 stops9h 43m

$1,053

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to San Francisco from

How to get the cheapest flight ticket from Florence, South Carolina to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to San Francisco?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to San Francisco from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 71% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 7 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to San Francisco (FLO to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to San Francisco

Fastest flight time

7h 37m

Direct flights

None
The fastest flight from Florence, South Carolina to San Francisco takes 7h 37m
There are no direct flights from Florence, South Carolina to San Francisco. There are no popular flight routes from Florence, South Carolina to San Francisco.
Search flight deals

  • How far is Florence to San Francisco by plane?

    The distance between Florence and San Francisco is about 2374.9 mi. In terms of flight time, this usually takes a little over 7h 37m.

  • When did momondo last update prices for flights from Florence Airport to San Francisco Airport?

    Prices for flights from Florence Airport to San Francisco Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Florence Airport to San Francisco Airport?

  • How old do you have to be to fly from Florence Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Florence, South Carolina to San Francisco?

Best airlines flying from Florence, South Carolina to San Francisco

Compare and see reviews for airlines that fly from Florence, South Carolina to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $326Free CancellationRating
7.2
11,048 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Berkeley
Santa Clara
Walnut Creek
Fremont
Daly City
Half Moon Bay
Vallejo
Salinas
Livermore
Sunnyvale
Turlock

Why use momondo?

Why should I use momondo to find a flight deal from Florence to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Florence to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Florence to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Florence which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Florence to San Francisco?

Once you have performed a search for Florence to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Florence to San Francisco right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Francisco, momondo offers a useful price alert feature which will track prices for flights to San Francisco from Florence and alert you when they change.

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