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Cheap flights from Florence, South Carolina to San Francisco from $204

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to San Francisco departing on 10/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Florence, South Carolina to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:09 am - 12:09 pm
FLO
-
SFO
10h 00m
1 stop
American Airlines Logo
12:00 pm - 10:58 pm
SFO
-
FLO
7h 58m
1 stop
$457American Airlines
Sun, Sep 20 - Sat, Sep 26
American Airlines Logo
5:09 am - 9:47 am
FLO
-
SFO
7h 38m
1 stop
American Airlines Logo
7:00 am - 10:58 pm
SFO
-
FLO
12h 58m
2 stops
$552American Airlines
Sun, Sep 20 - Sat, Sep 26
American Airlines Logo
6:22 am - 11:28 am
FLO
-
SFO
8h 06m
1 stop
American Airlines Logo
5:05 am - 2:56 pm
SFO
-
FLO
6h 51m
1 stop
$587American Airlines
Sat, Aug 8 - Wed, Aug 12
American Airlines Logo
3:22 pm - 10:40 pm
FLO
-
SFO
10h 18m
1 stop
American Airlines Logo
12:33 pm - 10:59 pm
SFO
-
FLO
7h 26m
1 stop
$628American Airlines
Fri, Aug 7 - Tue, Aug 11
American Airlines Logo
5:05 am - 12:14 pm
FLO
-
SFO
10h 09m
1 stop
American Airlines Logo
12:33 pm - 10:59 pm
SFO
-
FLO
7h 26m
1 stop
$648American Airlines
Sun, Aug 9 - Thu, Aug 13
American Airlines Logo
6:22 am - 11:28 am
FLO
-
SFO
8h 06m
1 stop
American Airlines Logo
1:14 pm - 11:58 pm
SFO
-
FLO
7h 44m
1 stop
$650American Airlines
Wed, Aug 5 - Sun, Aug 9
American Airlines Logo
3:22 pm - 10:40 pm
FLO
-
SFO
10h 18m
1 stop
American Airlines Logo
6:36 am - 10:59 pm
SFO
-
FLO
13h 23m
2 stops
$699American Airlines
Fri, Aug 7 - Tue, Aug 11
American Airlines Logo
3:22 pm - 10:18 pm
FLO
-
SFO
9h 56m
2 stops
American Airlines Logo
1:14 pm - 11:58 pm
SFO
-
FLO
7h 44m
1 stop
$762American Airlines
Wed, Aug 5 - Sun, Aug 9
American Airlines Logo
6:22 am - 4:02 pm
FLO
-
SFO
12h 40m
2 stops
American Airlines Logo
6:36 am - 10:59 pm
SFO
-
FLO
13h 23m
2 stops
$811American Airlines
Sat, Aug 8 - Wed, Aug 12
American Airlines Logo
3:22 pm - 10:18 pm
FLO
-
SFO
9h 56m
2 stops
American Airlines Logo
5:05 am - 2:56 pm
SFO
-
FLO
6h 51m
1 stop
$849American Airlines
Thu, Aug 6 - Mon, Aug 10

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American Airlines flights from Florence, South Carolina to San Francisco

Our best American Airlines deals on Florence, South Carolina to San Francisco flight tickets
American Airlines
Sep 20
FLO5:09 amFlorence
10h 00m
1 stop
SFO12:09 pmSan Francisco
Sep 26
SFO12:00 pmSan Francisco
7h 58m
1 stop
FLO10:58 pmFlorence
$457
American Airlines
Sep 20
FLO5:09 amFlorence
7h 38m
1 stop
SFO9:47 amSan Francisco
Sep 26
SFO7:00 amSan Francisco
12h 58m
2 stops
FLO10:58 pmFlorence
$552
American Airlines
Aug 8
FLO3:22 pmFlorence
10h 18m
1 stop
SFO10:40 pmSan Francisco
Aug 18
SFO12:33 pmSan Francisco
7h 26m
1 stop
FLO10:59 pmFlorence
$578

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 26, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 9/20

5:09 am-12:09 pm

1 stop10h 00m

San Francisco

Sat 9/26

12:00 pm-10:58 pm

1 stop7h 58m

$457

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 9/20

5:09 am-9:47 am

1 stop7h 38m

San Francisco

Sat 9/26

7:00 am-10:58 pm

2 stops12h 58m

$552
Quickest round-trip

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sat 8/8

6:22 am-11:28 am

1 stop8h 06m

San Francisco

Wed 8/12

5:05 am-2:56 pm

1 stop6h 51m

$587

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 8/7

3:22 pm-10:40 pm

1 stop10h 18m

San Francisco

Tue 8/11

12:33 pm-10:59 pm

1 stop7h 26m

$628

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 8/9

5:05 am-12:14 pm

1 stop10h 09m

San Francisco

Thu 8/13

12:33 pm-10:59 pm

1 stop7h 26m

$648

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 8/5

6:22 am-11:28 am

1 stop8h 06m

San Francisco

Sun 8/9

1:14 pm-11:58 pm

1 stop7h 44m

$650

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 8/7

3:22 pm-10:40 pm

1 stop10h 18m

San Francisco

Tue 8/11

6:36 am-10:59 pm

2 stops13h 23m

$699

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 8/5

3:22 pm-10:18 pm

2 stops9h 56m

San Francisco

Sun 8/9

1:14 pm-11:58 pm

1 stop7h 44m

$762

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sat 8/8

6:22 am-4:02 pm

2 stops12h 40m

San Francisco

Wed 8/12

6:36 am-10:59 pm

2 stops13h 23m

$811

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Thu 8/6

3:22 pm-10:18 pm

2 stops9h 56m

San Francisco

Mon 8/10

5:05 am-2:56 pm

1 stop6h 51m

$849

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Florence, South Carolina to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Florence to San Francisco?

American Airlines is the most popular carrier operating from Florence to San Francisco

What airlines fly to San Francisco?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to San Francisco from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 70% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 7 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to San Francisco (FLO to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to San Francisco

Fastest flight time

8h 06m

Direct flights

None
The fastest flight from Florence, South Carolina to San Francisco takes 8h 06m
There are no direct flights from Florence, South Carolina to San Francisco. There are no popular flight routes from Florence, South Carolina to San Francisco.
Search flight deals

Frequently asked questions about flying from Florence, South Carolina to San Francisco

  • How far is Florence to San Francisco by plane?

    The distance between Florence and San Francisco is about 2374.4 mi. In terms of flight time, this usually takes a little over 8h 06m.

  • When did momondo last update prices for flights from Florence Airport to San Francisco Airport?

    Prices for flights from Florence Airport to San Francisco Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Florence Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Florence Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
South San Francisco
Fremont
Hayward
Walnut Creek
Bodega Bay
Sonoma
Roseville
Santa Clara
Berkeley
Vallejo
Salinas
Sunnyvale
Burlingame
Daly City
Milpitas
Palo Alto
Big Sur

Why use momondo?

Why should I use momondo to find a flight deal from Florence to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Florence to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Florence to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Florence which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Florence to San Francisco?

Once you have performed a search for Florence to San Francisco flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Florence to San Francisco right now. Can momondo alert me if prices change?

If you are simply researching potential flights to San Francisco, momondo offers a useful price alert feature which will track prices for flights to San Francisco from Florence and alert you when they change.

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