Cheap flights from Detroit Metropolitan Wayne County Airport to San Francisco from $223

If you aren’t able to travel to San Francisco during the month of January, then flying in February is also cheap. Prices for this month can be found on momondo for an average of $413.

The cheapest day to depart from Detroit Metropolitan Wayne County Airport to San Francisco is on a Thursday when prices can be found for as low as $490. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $676.

Our data shows that the cheapest Detroit Metropolitan Wayne County Airport to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $499. Flights in the afternoon are often more expensive with an average ticket price of $590.

Fly from Detroit Metropolitan Wayne County to San Francisco for the best Detroit Metropolitan Wayne County - San Francisco flight prices

You are more likely to see cheaper flights to San Francisco from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $460 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Detroit Metropolitan Wayne County Airport for as low as $357 on momondo.

There are 4 cabin classes available to choose from on Detroit Metropolitan Wayne County Airport to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Alaska Airlines, Southwest, and Delta are the most popular carriers operating from Detroit Metropolitan Wayne County to San Francisco

Delta, United Airlines and Frontier are the top three most popular airlines that fly to San Francisco from Detroit Metropolitan Wayne County Airport according to our data. Delta is the first choice among our users, with 47% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 6 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

Denver (DEN) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Denver (DEN) offer the lowest average round-trip price of $227.

Flights connecting via St. Louis (STL) have the shortest average one-way travel time: 6h 40m.

St. Louis (STL) has the shortest average layover time for this route: 1h 10m.

The number of flights available between Detroit Metropolitan Wayne County Airport and San Francisco is 7 per day as of October 2026. The most frequent departure time is 4:00PM, with 45% of daily flights leaving in the afternoon.

As of October 2026, there are 52 flights per week flying from Detroit Metropolitan Wayne County Airport to San Francisco. The most common day of the week flights depart is Thu, with 35% of flights taking off on this day.