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Cheap flights from Des Moines to San Francisco from $240

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 1/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
6:40 am - 10:20 am
DSM
-
STS
5h 40m1 stop
Southwest Logo
6:00 am - 5:55 pm
STS
-
DSM
9h 55m2 stops
$484Southwest
Sat, May 9 - Wed, May 13
Southwest Logo
6:40 am - 8:30 pm
DSM
-
STS
15h 50m2 stops
Southwest Logo
6:00 am - 5:55 pm
STS
-
DSM
9h 55m2 stops
$523Southwest
Sat, May 9 - Wed, May 13
American Airlines Logo
5:46 am - 3:47 pm
DSM
-
STS
12h 01m1 stop
American Airlines Logo
4:17 pm - 1:17 pm
STS
-
DSM
19h 00m1 stop
$580American Airlines
Sat, May 9 - Wed, May 13
American Airlines Logo
5:58 am - 3:47 pm
DSM
-
STS
11h 49m2 stops
American Airlines Logo
12:46 pm - 11:41 pm
STS
-
DSM
8h 55m1 stop
$594American Airlines
Sat, May 9 - Wed, May 13
American Airlines Logo
5:21 am - 12:29 pm
DSM
-
STS
9h 08m1 stop
American Airlines Logo
4:21 pm - 12:29 am
STS
-
DSM
6h 08m1 stop
$813American Airlines
Mon, Dec 22 - Mon, Dec 29
American Airlines Logo
6:20 pm - 12:29 pm
DSM
-
STS
20h 09m1 stop
American Airlines Logo
4:21 pm - 12:29 am
STS
-
DSM
6h 08m1 stop
$855American Airlines
Sun, Dec 21 - Mon, Dec 29
American Airlines Logo
3:38 pm - 12:29 pm
DSM
-
STS
22h 51m2 stops
American Airlines Logo
4:21 pm - 12:29 am
STS
-
DSM
6h 08m1 stop
$860American Airlines
Sun, Dec 21 - Mon, Dec 29
American Airlines Logo
5:21 am - 12:29 pm
DSM
-
STS
9h 08m1 stop
American Airlines Logo
4:21 pm - 12:29 am
STS
-
DSM
6h 08m1 stop
$882American Airlines
Mon, Dec 22 - Sat, Dec 27
American Airlines Logo
6:20 pm - 12:29 pm
DSM
-
STS
20h 09m1 stop
American Airlines Logo
4:21 pm - 12:29 am
STS
-
DSM
6h 08m1 stop
$924American Airlines
Sun, Dec 21 - Sat, Dec 27
American Airlines Logo
3:55 pm - 12:29 pm
DSM
-
STS
22h 34m2 stops
American Airlines Logo
4:21 pm - 12:29 am
STS
-
DSM
6h 08m1 stop
$929American Airlines
Sun, Dec 21 - Sat, Dec 27

Southwest flights from Des Moines to Santa Rosa

Our best Southwest deals on Des Moines to Santa Rosa flight tickets
Southwest
May 9
DSM6:40 amDes Moines
5h 40m
1 stop
STS10:20 amSanta Rosa Sonoma County
May 13
STS6:00 amSanta Rosa Sonoma County
9h 55m
2 stops
DSM5:55 pmDes Moines
$484
Find similar
Southwest
May 9
DSM6:40 amDes Moines
15h 50m
2 stops
STS8:30 pmSanta Rosa Sonoma County
May 13
STS6:00 amSanta Rosa Sonoma County
9h 55m
2 stops
DSM5:55 pmDes Moines
$523
Find similar

American Airlines flights from Des Moines to Santa Rosa

Our best American Airlines deals on Des Moines to Santa Rosa flight tickets
American Airlines
May 9
DSM5:46 amDes Moines
12h 01m
1 stop
STS3:47 pmSanta Rosa Sonoma County
May 13
STS4:17 pmSanta Rosa Sonoma County
19h 00m
1 stop
DSM1:17 pmDes Moines
$580
Find similar
American Airlines
May 9
DSM5:58 amDes Moines
11h 49m
2 stops
STS3:47 pmSanta Rosa Sonoma County
May 13
STS12:46 pmSanta Rosa Sonoma County
8h 55m
1 stop
DSM11:41 pmDes Moines
$594
Find similar
American Airlines
Dec 22
DSM5:21 amDes Moines
9h 08m
1 stop
STS12:29 pmSanta Rosa Sonoma County
Dec 29
STS4:21 pmSanta Rosa Sonoma County
6h 08m
1 stop
DSM12:29 amDes Moines
$813
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Rosa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Des Moines to Santa Rosa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanta Rosa

DSM - STS

DSMSTS

Des Moines

Sat 5/9

6:40 am-10:20 am

1 stop5h 40m

Santa Rosa Sonoma County

Wed 5/13

6:00 am-5:55 pm

2 stops9h 55m

$484

Des MoinesSanta Rosa

DSM - STS

DSMSTS

Des Moines

Sat 5/9

6:40 am-8:30 pm

2 stops15h 50m

Santa Rosa Sonoma County

Wed 5/13

6:00 am-5:55 pm

2 stops9h 55m

$523

Des MoinesSanta Rosa

DSM - STS

DSMSTS

Des Moines

Sat 5/9

5:46 am-3:47 pm

1 stop12h 01m

Santa Rosa Sonoma County

Wed 5/13

4:17 pm-1:17 pm

1 stop19h 00m

$580

Des MoinesSanta Rosa

DSM - STS

DSMSTS

Des Moines

Sat 5/9

5:58 am-3:47 pm

2 stops11h 49m

Santa Rosa Sonoma County

Wed 5/13

12:46 pm-11:41 pm

1 stop8h 55m

$594

Des MoinesSanta Rosa

DSM - STS

DSMSTS

Des Moines

Mon 12/22

5:21 am-12:29 pm

1 stop9h 08m

Santa Rosa Sonoma County

Mon 12/29

4:21 pm-12:29 am

1 stop6h 08m

$813

Des MoinesSanta Rosa

DSM - STS

DSMSTS

Des Moines

Sun 12/21

6:20 pm-12:29 pm

1 stop20h 09m

Santa Rosa Sonoma County

Mon 12/29

4:21 pm-12:29 am

1 stop6h 08m

$855

Des MoinesSanta Rosa

DSM - STS

DSMSTS

Des Moines

Sun 12/21

3:38 pm-12:29 pm

2 stops22h 51m

Santa Rosa Sonoma County

Mon 12/29

4:21 pm-12:29 am

1 stop6h 08m

$860

Des MoinesSanta Rosa

DSM - STS

DSMSTS

Des Moines

Mon 12/22

5:21 am-12:29 pm

1 stop9h 08m

Santa Rosa Sonoma County

Sat 12/27

4:21 pm-12:29 am

1 stop6h 08m

$882

Des MoinesSanta Rosa

DSM - STS

DSMSTS

Des Moines

Sun 12/21

6:20 pm-12:29 pm

1 stop20h 09m

Santa Rosa Sonoma County

Sat 12/27

4:21 pm-12:29 am

1 stop6h 08m

$924

Des MoinesSanta Rosa

DSM - STS

DSMSTS

Des Moines

Sun 12/21

3:55 pm-12:29 pm

2 stops22h 34m

Santa Rosa Sonoma County

Sat 12/27

4:21 pm-12:29 am

1 stop6h 08m

$929

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Des Moines to Santa Rosa

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Santa Rosa Sonoma County?

American Airlines and Alaska Airlines are the most popular carriers operating from Des Moines to Santa Rosa Sonoma County

What airlines fly to Santa Rosa?

American Airlines, United Airlines and Southwest are the top three most popular airlines that fly to Santa Rosa from Des Moines according to our data. American Airlines is the first choice among our users, with 36% of people opting to fly with this airline when traveling to Santa Rosa. Keep in mind that there are 5 different airlines that fly to Santa Rosa on a routine basis, so you have a few additional options to choose from.

When to book flights from Des Moines to Santa Rosa

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Rosa according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Rosa (DSM to STS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Rosa

Fastest flight time

9h 08m

Direct flights

None
The fastest flight from Des Moines to Santa Rosa takes 9h 08m
There are no direct flights from Des Moines to Santa Rosa. There are no popular flight routes from Des Moines to Santa Rosa.
Search flight deals

  • How far is Des Moines to Santa Rosa Sonoma County by plane?

    There are 1545.9 mi between Des Moines and Santa Rosa Sonoma County. Typically, this will take 9h 08m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Rosa Sonoma County Airport?

    Prices for flights from Des Moines Airport to Santa Rosa Sonoma County Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Rosa Sonoma County Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Rosa Sonoma County Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Rosa Sonoma County Airport.

  • What documentation or ID do you need to fly to Santa Rosa Sonoma County Airport?

    The required travel and health documents for your Santa Rosa Sonoma County Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Rosa Sonoma County Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Des Moines to Santa Rosa?

Best airlines flying from Des Moines to Santa Rosa

Compare and see reviews for airlines that fly from Des Moines to Santa Rosa with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $573Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Fort Bragg
Mendocino
Ukiah
Little River
Point Arena

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Rosa?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Santa Rosa. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Santa Rosa with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santa Rosa from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Santa Rosa?

Once all potential Des Moines to Santa Rosa flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Santa Rosa right now. Can momondo alert me if prices change?

Price alerts on flights to Santa Rosa from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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