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Cheap flights from Des Moines to San Francisco from $211

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to San Francisco departing on 8/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
2:25 pm - 10:35 pmDSM  Des Moines-STS Santa Rosa Sonoma County
10h 10m2 stops Denver Intl San Diego
Southwest Logo
6:00 am - 9:00 pmSTS  Santa Rosa Sonoma County-DSM Des Moines
13h 00m2 stops San Diego Denver Intl
$365Southwest
Mon, Aug 31 - Wed, Sep 2
Southwest Logo
7:00 am - 12:15 pmDSM  Des Moines-STS Santa Rosa Sonoma County
7h 15m1 stop Denver Intl
Southwest Logo
6:00 am - 9:00 pmSTS  Santa Rosa Sonoma County-DSM Des Moines
13h 00m2 stops San Diego Denver Intl
$372Southwest
Mon, Aug 31 - Wed, Sep 2
American Airlines Logo
5:30 am - 12:28 pmDSM  Des Moines-STS Santa Rosa Sonoma County
8h 58m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
12:39 pm - 11:12 pmSTS  Santa Rosa Sonoma County-DSM Des Moines
8h 33m1 stop Dallas/Fort Worth
$407American Airlines
Sat, Sep 5 - Wed, Sep 16
American Airlines Logo
5:30 am - 12:28 pmDSM  Des Moines-STS Santa Rosa Sonoma County
8h 58m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
1:08 pm - 11:59 pmSTS  Santa Rosa Sonoma County-DSM Des Moines
8h 51m1 stop Phoenix Sky Harbor Intl
$419American Airlines
Sat, Sep 5 - Wed, Sep 16
American Airlines Logo
5:30 am - 12:28 pmDSM  Des Moines-STS Santa Rosa Sonoma County
8h 58m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
12:58 pm - 8:46 pmSTS  Santa Rosa Sonoma County-DSM Des Moines
5h 48m1 stop Phoenix Sky Harbor Intl
$421American Airlines
Sat, Aug 22 - Wed, Aug 26
American Airlines Logo
8:10 am - 12:48 pmDSM  Des Moines-STS Santa Rosa Sonoma County
6h 38m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
12:44 pm - 11:30 pmSTS  Santa Rosa Sonoma County-DSM Des Moines
8h 46m1 stop Dallas/Fort Worth
$421American Airlines
Tue, Nov 3 - Tue, Nov 10
American Airlines Logo
8:10 am - 12:48 pmDSM  Des Moines-STS Santa Rosa Sonoma County
6h 38m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
12:44 pm - 11:30 pmSTS  Santa Rosa Sonoma County-DSM Des Moines
8h 46m1 stop Dallas/Fort Worth
$421American Airlines
Tue, Nov 3 - Tue, Nov 10
American Airlines Logo
8:10 am - 12:48 pmDSM  Des Moines-STS Santa Rosa Sonoma County
6h 38m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
1:18 pm - 12:18 amSTS  Santa Rosa Sonoma County-DSM Des Moines
9h 00m2 stops Phoenix Sky Harbor Intl Chicago O'Hare Intl
$426American Airlines
Tue, Nov 3 - Tue, Nov 10
American Airlines Logo
5:30 am - 12:28 pmDSM  Des Moines-STS Santa Rosa Sonoma County
8h 58m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
12:58 pm - 12:20 amSTS  Santa Rosa Sonoma County-DSM Des Moines
9h 22m2 stops Phoenix Sky Harbor Intl Chicago O'Hare Intl
$426American Airlines
Sat, Aug 22 - Wed, Aug 26
American Airlines Logo
8:10 am - 12:48 pmDSM  Des Moines-STS Santa Rosa Sonoma County
6h 38m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
1:18 pm - 12:18 amSTS  Santa Rosa Sonoma County-DSM Des Moines
9h 00m2 stops Phoenix Sky Harbor Intl Chicago O'Hare Intl
$426American Airlines
Tue, Nov 3 - Tue, Nov 10

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Southwest flights from Des Moines to Santa Rosa

Our best Southwest deals on Des Moines to Santa Rosa flight tickets
Southwest
Aug 31
DSM2:25 pmDes Moines
10h 10m
2 stops
STS10:35 pmSanta Rosa Sonoma County
Sep 2
STS6:00 amSanta Rosa Sonoma County
13h 00m
2 stops
DSM9:00 pmDes Moines
$365
Southwest
Aug 31
DSM7:00 amDes Moines
7h 15m
1 stop
STS12:15 pmSanta Rosa Sonoma County
Sep 2
STS6:00 amSanta Rosa Sonoma County
13h 00m
2 stops
DSM9:00 pmDes Moines
$372
Southwest
Nov 3
DSM7:00 amDes Moines
7h 15m
2 stops
STS12:15 pmSanta Rosa Sonoma County
Nov 10
STS6:45 amSanta Rosa Sonoma County
9h 05m
2 stops
DSM5:50 pmDes Moines
$431

American Airlines flights from Des Moines to Santa Rosa

Our best American Airlines deals on Des Moines to Santa Rosa flight tickets
American Airlines
Sep 5
DSM5:30 amDes Moines
8h 58m
1 stop
STS12:28 pmSanta Rosa Sonoma County
Sep 16
STS12:39 pmSanta Rosa Sonoma County
8h 33m
1 stop
DSM11:12 pmDes Moines
$407
American Airlines
Sep 5
DSM5:30 amDes Moines
8h 58m
1 stop
STS12:28 pmSanta Rosa Sonoma County
Sep 16
STS1:08 pmSanta Rosa Sonoma County
8h 51m
1 stop
DSM11:59 pmDes Moines
$419
American Airlines
Nov 3
DSM8:10 amDes Moines
6h 38m
1 stop
STS12:48 pmSanta Rosa Sonoma County
Nov 10
STS12:44 pmSanta Rosa Sonoma County
8h 46m
1 stop
DSM11:30 pmDes Moines
$421

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Rosa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 9, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Rosa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanta Rosa

DSM Des Moines - STS Santa Rosa Sonoma County

DSMSTS

Des Moines

Mon 8/31

2:25 pm-10:35 pm

2 stops10h 10m

Santa Rosa Sonoma County

Wed 9/2

6:00 am-9:00 pm

2 stops13h 00m

$365

Des MoinesSanta Rosa

DSM Des Moines - STS Santa Rosa Sonoma County

DSMSTS

Des Moines

Mon 8/31

7:00 am-12:15 pm

1 stop7h 15m

Santa Rosa Sonoma County

Wed 9/2

6:00 am-9:00 pm

2 stops13h 00m

$372

Des MoinesSanta Rosa

DSM Des Moines - STS Santa Rosa Sonoma County

DSMSTS

Des Moines

Sat 9/5

5:30 am-12:28 pm

1 stop8h 58m

Santa Rosa Sonoma County

Wed 9/16

12:39 pm-11:12 pm

1 stop8h 33m

$407

Des MoinesSanta Rosa

DSM Des Moines - STS Santa Rosa Sonoma County

DSMSTS

Des Moines

Sat 9/5

5:30 am-12:28 pm

1 stop8h 58m

Santa Rosa Sonoma County

Wed 9/16

1:08 pm-11:59 pm

1 stop8h 51m

$419
Quickest round-trip

Des MoinesSanta Rosa

DSM Des Moines - STS Santa Rosa Sonoma County

DSMSTS

Des Moines

Sat 8/22

5:30 am-12:28 pm

1 stop8h 58m

Santa Rosa Sonoma County

Wed 8/26

12:58 pm-8:46 pm

1 stop5h 48m

$421

Des MoinesSanta Rosa

DSM Des Moines - STS Santa Rosa Sonoma County

DSMSTS

Des Moines

Tue 11/3

8:10 am-12:48 pm

1 stop6h 38m

Santa Rosa Sonoma County

Tue 11/10

12:44 pm-11:30 pm

1 stop8h 46m

$421

Des MoinesSanta Rosa

DSM Des Moines - STS Santa Rosa Sonoma County

DSMSTS

Des Moines

Tue 11/3

8:10 am-12:48 pm

1 stop6h 38m

Santa Rosa Sonoma County

Tue 11/10

12:44 pm-11:30 pm

1 stop8h 46m

$421

Des MoinesSanta Rosa

DSM Des Moines - STS Santa Rosa Sonoma County

DSMSTS

Des Moines

Tue 11/3

8:10 am-12:48 pm

1 stop6h 38m

Santa Rosa Sonoma County

Tue 11/10

1:18 pm-12:18 am

2 stops9h 00m

$426

Des MoinesSanta Rosa

DSM Des Moines - STS Santa Rosa Sonoma County

DSMSTS

Des Moines

Sat 8/22

5:30 am-12:28 pm

1 stop8h 58m

Santa Rosa Sonoma County

Wed 8/26

12:58 pm-12:20 am

2 stops9h 22m

$426

Des MoinesSanta Rosa

DSM Des Moines - STS Santa Rosa Sonoma County

DSMSTS

Des Moines

Tue 11/3

8:10 am-12:48 pm

1 stop6h 38m

Santa Rosa Sonoma County

Tue 11/10

1:18 pm-12:18 am

2 stops9h 00m

$426

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Santa Rosa

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Santa Rosa flights?

You could potentially save up to 28% on your flight if you consider stops on a Des Moines to Santa Rosa flight.

When to book flights from Des Moines to Santa Rosa

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Rosa according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Rosa (DSM to STS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Rosa

Fastest flight time

5h 40m

Direct flights

None
The fastest flight from Des Moines to Santa Rosa takes 5h 40m
There are no direct flights from Des Moines to Santa Rosa. There are no popular flight routes from Des Moines to Santa Rosa.
Search flight deals

Frequently asked questions about flying from Des Moines to Santa Rosa

  • How far is Des Moines to Santa Rosa Sonoma County by plane?

    There are 1545.9 mi between Des Moines and Santa Rosa Sonoma County. Typically, this will take 5h 40m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Rosa Sonoma County Airport?

    Prices for flights from Des Moines Airport to Santa Rosa Sonoma County Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Rosa Sonoma County Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Rosa Sonoma County Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Rosa Sonoma County Airport.

  • What documentation or ID do you need to fly to Santa Rosa Sonoma County Airport?

    The required travel and health documents for your Santa Rosa Sonoma County Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Rosa Sonoma County Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Des Moines to Santa Rosa?

Best airlines flying from Des Moines to Santa Rosa

Compare and see reviews for airlines that fly from Des Moines to Santa Rosa with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $496Free CancellationRating
7.1
11,895 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Fort Bragg
Ukiah
Mendocino
Little River
Point Arena

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Rosa?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Santa Rosa. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Santa Rosa with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santa Rosa from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Santa Rosa?

Once all potential Des Moines to Santa Rosa flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Santa Rosa right now. Can momondo alert me if prices change?

Price alerts on flights to Santa Rosa from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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