Cheap flights from St. Louis to San Francisco from $85

If you aren’t able to travel to San Francisco during the month of October, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $371.

The cheapest day to depart from St. Louis to San Francisco is on a Friday when prices can be found for as low as $681. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $972.

Our data shows that the cheapest St. Louis to San Francisco flights are usually those with departure times at noon. Our users have found flights to San Francisco at noon for as low as $472. Flights in the evening are often more expensive with an average ticket price of $1,213.

Fly from Lambert-St Louis to San Francisco for the best Lambert-St Louis - San Francisco flight prices

You are more likely to see cheaper flights to San Francisco from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $438 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from St. Louis for as low as $327 on momondo.

There are 4 cabin classes available to choose from on Lambert-St Louis to San Francisco flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between St. Louis to San Francisco.

As of April 2026, prices for St. Louis to San Francisco flights are approximately 30% more expensive when compared to flights at the same time last year.

United Airlines, Alaska Airlines, and Southwest are the most popular carriers operating from Lambert-St Louis to San Francisco

Southwest, United Airlines and Frontier are the top three most popular airlines that fly to San Francisco from St. Louis according to our data. Southwest is the first choice among our users, with 42% of people opting to fly with this airline when traveling to San Francisco. Keep in mind that there are 5 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

Denver (DEN) was the most common stop: 92% of momondo users choosing 1-stop flights on this route connected there.

Flights via Denver (DEN) offer the lowest average round-trip price of $224.

Flights connecting via Dallas (DFW) have the shortest average one-way travel time: 9h 03m.

Denver (DEN) has the shortest average layover time for this route: 2h 27m.

As of April 2026, 5 flights take off from St. Louis and land in San Francisco each day. The most common flight departure time for this route is 7:00PM, with 50% of daily flights taking off in the evening.

The number of flights available between St. Louis and San Francisco is 36 per week as of April 2026. The most frequent departure day is Mon, with 17% of weekly flights leaving on this day.