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Cheap flights from South America to San Diego from $243

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South America to San Diego departing on 8/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South America to San Diego

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:10 pm - 6:09 pm
MDE
-
SAN
29h 59m
2 stops
Multiple Airlines Logo
11:53 am - 1:10 pm
SAN
-
MDE
23h 17m
2 stops
$419Multiple Airlines
Mon, Aug 17 - Wed, Oct 21
Multiple Airlines Logo
10:40 pm - 8:08 pm
MDE
-
SAN
23h 28m
1 stop
Multiple Airlines Logo
4:00 pm - 1:10 pm
SAN
-
MDE
19h 10m
2 stops
$451Multiple Airlines
Mon, Aug 17 - Wed, Oct 21
LATAM Airlines Logo
6:45 am - 11:25 am
CLO
-
SAN
30h 40m
2 stops
LATAM Airlines Logo
10:25 pm - 6:05 am
SAN
-
CLO
29h 40m
2 stops
$522LATAM Airlines
Fri, Sep 25 - Mon, Sep 28
Copa Airlines Logo
1:25 am - 6:30 pm
GIG
-
SAN
21h 05m
1 stop
Copa Airlines Logo
10:00 pm - 7:40 am
SAN
-
GIG
29h 40m
1 stop
$540Copa Airlines
Tue, Aug 11 - Sun, Aug 16
Delta Logo
9:00 pm - 9:26 am
GIG
-
SAN
16h 26m
1 stop
Delta Logo
8:00 am - 4:35 pm
SAN
-
GIG
28h 35m
2 stops
$544Delta
Thu, Aug 6 - Sat, Sep 12
Delta Logo
7:00 am - 8:36 pm
GIG
-
SAN
41h 36m
2 stops
Delta Logo
10:37 am - 10:15 am
SAN
-
GIG
19h 38m
1 stop
$551Delta
Sun, Aug 9 - Sun, Sep 6
LATAM Airlines Logo
7:10 am - 9:46 am
GIG
-
SAN
30h 36m
2 stops
LATAM Airlines Logo
2:00 pm - 4:35 pm
SAN
-
GIG
22h 35m
2 stops
$552LATAM Airlines
Thu, Sep 24 - Sun, Sep 27
Copa Airlines Logo
4:14 am - 6:30 pm
SCL
-
SAN
17h 16m
1 stop
Copa Airlines Logo
10:00 pm - 5:10 am
SAN
-
SCL
28h 10m
1 stop
$653Copa Airlines
Sun, Aug 16 - Wed, Sep 2
United Airlines Logo
10:45 pm - 11:35 am
SCL
-
SAN
17h 50m
2 stops
United Airlines Logo
7:41 pm - 8:50 am
SAN
-
SCL
32h 09m
2 stops
$655United Airlines
Tue, Nov 3 - Sat, Nov 14
United Airlines Logo
9:45 pm - 11:35 am
SCL
-
SAN
17h 50m
2 stops
United Airlines Logo
8:00 am - 8:50 am
SAN
-
SCL
19h 50m
1 stop
$665United Airlines
Wed, Oct 28 - Sun, Nov 8

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LATAM Airlines flights from South America to San Diego

Our best LATAM Airlines deals on South America to San Diego flight tickets
LATAM Airlines
Sep 25
CLO6:45 amCali Alfonso B. Aragon Intl
30h 40m
2 stops
SAN11:25 amSan Diego
Sep 28
SAN10:25 pmSan Diego
29h 40m
2 stops
CLO6:05 amCali Alfonso B. Aragon Intl
$522
LATAM Airlines
Sep 24
GIG7:10 amRio de Janeiro–Galeão Intl
30h 36m
2 stops
SAN9:46 amSan Diego
Sep 27
SAN2:00 pmSan Diego
22h 35m
2 stops
GIG4:35 pmRio de Janeiro–Galeão Intl
$552
LATAM Airlines
Aug 12
GIG7:10 amRio de Janeiro–Galeão Intl
30h 16m
2 stops
SAN9:26 amSan Diego
Sep 7
SAN10:25 pmSan Diego
38h 10m
2 stops
GIG4:35 pmRio de Janeiro–Galeão Intl
$553

United Airlines flights from South America to San Diego

Our best United Airlines deals on South America to San Diego flight tickets
United Airlines
Sep 12
CLO8:48 amCali Alfonso B. Aragon Intl
28h 10m
2 stops
SAN10:58 amSan Diego
Oct 3
SAN10:13 amSan Diego
35h 24m
2 stops
CLO11:37 pmCali Alfonso B. Aragon Intl
$624
United Airlines
Aug 28
CLO5:02 amCali Alfonso B. Aragon Intl
34h 15m
2 stops
SAN1:17 pmSan Diego
Aug 31
SAN8:00 amSan Diego
31h 33m
2 stops
CLO5:33 pmCali Alfonso B. Aragon Intl
$626
United Airlines
Aug 28
CLO5:02 amCali Alfonso B. Aragon Intl
34h 15m
2 stops
SAN1:17 pmSan Diego
Aug 31
SAN8:00 amSan Diego
31h 33m
2 stops
CLO5:33 pmCali Alfonso B. Aragon Intl
$627

momondo Fare Finder

 
Customize your flight search to find flights from South America to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 10, 2026.
Use the filters below to find and compare flights from South America to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedellínSan Diego

MDE - SAN

MDESAN

Medellín Jose Maria Cordova Intl

Mon 8/17

2:10 pm-6:09 pm

2 stops29h 59m

San Diego

Wed 10/21

11:53 am-1:10 pm

2 stops23h 17m

$419

MedellínSan Diego

MDE - SAN

MDESAN

Medellín Jose Maria Cordova Intl

Mon 8/17

10:40 pm-8:08 pm

1 stop23h 28m

San Diego

Wed 10/21

4:00 pm-1:10 pm

2 stops19h 10m

$451

CaliSan Diego

CLO - SAN

CLOSAN

Cali Alfonso B. Aragon Intl

Fri 9/25

6:45 am-11:25 am

2 stops30h 40m

San Diego

Mon 9/28

10:25 pm-6:05 am

2 stops29h 40m

$522

Rio de JaneiroSan Diego

GIG - SAN

GIGSAN

Rio de Janeiro–Galeão Intl

Tue 8/11

1:25 am-6:30 pm

1 stop21h 05m

San Diego

Sun 8/16

10:00 pm-7:40 am

1 stop29h 40m

$540

Rio de JaneiroSan Diego

GIG - SAN

GIGSAN

Rio de Janeiro–Galeão Intl

Thu 8/6

9:00 pm-9:26 am

1 stop16h 26m

San Diego

Sat 9/12

8:00 am-4:35 pm

2 stops28h 35m

$544

Rio de JaneiroSan Diego

GIG - SAN

GIGSAN

Rio de Janeiro–Galeão Intl

Sun 8/9

7:00 am-8:36 pm

2 stops41h 36m

San Diego

Sun 9/6

10:37 am-10:15 am

1 stop19h 38m

$551

Rio de JaneiroSan Diego

GIG - SAN

GIGSAN

Rio de Janeiro–Galeão Intl

Thu 9/24

7:10 am-9:46 am

2 stops30h 36m

San Diego

Sun 9/27

2:00 pm-4:35 pm

2 stops22h 35m

$552

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Sun 8/16

4:14 am-6:30 pm

1 stop17h 16m

San Diego

Wed 9/2

10:00 pm-5:10 am

1 stop28h 10m

$653

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Tue 11/3

10:45 pm-11:35 am

2 stops17h 50m

San Diego

Sat 11/14

7:41 pm-8:50 am

2 stops32h 09m

$655
Quickest round-trip

SantiagoSan Diego

SCL - SAN

SCLSAN

Santiago Arturo Merino Benitez

Wed 10/28

9:45 pm-11:35 am

2 stops17h 50m

San Diego

Sun 11/8

8:00 am-8:50 am

1 stop19h 50m

$665

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Diego from

How to get the cheapest flight ticket from South America to San Diego

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Diego?

If you are unable to visit San Diego during the month of April, then departing from South America during the month August is also very affordable. Most momondo users find prices during this month for around $186.

How far in advance should I book a flight from South America to San Diego?

You are more likely to see cheaper flights to San Diego from South America when booking weeks ahead of your departure date. In general, you can expect to find flights to San Diego for around $789 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Diego from South America for as low as $592 on momondo.

Can stopping save me money on South America to San Diego flights?

You could potentially save up to 16% on your flight if you consider stops on a South America to San Diego flight.

Cheap South America to San Diego flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South America to San Diego

Fastest flight time

11h 48m

Direct flights

None
The fastest flight from South America to San Diego takes 11h 48m
There are no direct flights from South America to San Diego. There are no popular flight routes from South America to San Diego.
Search flight deals

Frequently asked questions about flying from South America to San Diego

  • When did momondo last update prices for flights from South America to San Diego Airport?

    Prices for flights from South America to San Diego Airport were last updated today.

  • How many operators does momondo search for flights from South America to San Diego Airport?

  • How old do you have to be to fly from South America to San Diego Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South America to San Diego Airport.

  • What documentation or ID do you need to fly to San Diego Airport?

    The travel and health documents you'll need for your trip to San Diego Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at San Diego Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South America to San Diego

Compare and see reviews for airlines that fly from South America to San Diego with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $242Free CancellationRating
7.4
9,965 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $340Free CancellationRating
7.6
1,565 reviews
Search Copa Airlines flights
American AirlinesPriceFrom $466Free CancellationRating
7.1
11,798 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $471Free CancellationRating
7.4
1,952 reviews
Search LATAM Airlines flights
DeltaPriceFrom $489Free CancellationRating
7.8
8,456 reviews
Search Delta flights
GOLPriceFrom $607Free CancellationRating
7.3
1,257 reviews
Search GOL flights

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
Chula Vista
Coronado
El Cajon
Julian
National City
La Mesa
Poway
San Ysidro
Imperial Beach
Borrego Springs
Santee
Lemon Grove
Alpine

Why use momondo?

Why should I use momondo to find a flight deal from South America to San Diego?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South America to San Diego. momondo saves you time and could save you money on your trip.

Can I find flights from South America to San Diego with flexible booking policies on momondo?

Flights from South America to San Diego with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from South America to San Diego?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to San Diego from South America.

I’m not ready to book a flight from South America to San Diego right now. Can momondo alert me if prices change?

If you are not ready to book a flight from South America to San Diego now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to San Diego and let you know when they change.

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