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Cheap flights from Roanoke to San Francisco from $250

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to San Francisco departing on 12/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Roanoke to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:58 pm - 10:52 pmROA-SFO
9h 54m1 stop
American Airlines Logo
6:15 am - 8:17 pmSFO-ROA
11h 02m1 stop
$309American Airlines
Find Deal
Tue, Apr 28 - Wed, May 6
American Airlines Logo
6:10 pm - 10:52 pmROA-SFO
7h 42m1 stop
American Airlines Logo
10:36 pm - 8:29 amSFO-ROA
6h 53m1 stop
$334American Airlines
Find Deal
Thu, Apr 23 - Mon, Apr 27
American Airlines Logo
3:58 pm - 10:32 pmROA-SFO
9h 34m2 stops
American Airlines Logo
6:15 am - 5:31 pmSFO-ROA
8h 16m1 stop
$339American Airlines
Find Deal
Tue, Apr 28 - Wed, May 6
United Airlines Logo
2:55 pm - 9:01 pmROA-SFO
9h 06m1 stop
United Airlines Logo
11:44 pm - 10:06 amSFO-ROA
7h 22m1 stop
$349United Airlines
Find Deal
Mon, Dec 8 - Sat, Dec 13
American Airlines Logo
12:58 pm - 8:23 pmROA-SFO
10h 25m2 stops
American Airlines Logo
12:25 am - 10:34 amSFO-ROA
7h 09m1 stop
$354American Airlines
Find Deal
Mon, Dec 8 - Fri, Dec 12
Delta Logo
6:00 am - 5:56 pmROA-SFO
14h 56m2 stops
Delta Logo
2:05 pm - 12:08 amSFO-ROA
7h 03m1 stop
$357Delta
Find Deal
Wed, Feb 25 - Sat, Feb 28
American Airlines Logo
2:03 pm - 10:36 pmROA-SFO
11h 33m2 stops
American Airlines Logo
10:15 am - 12:03 amSFO-ROA
10h 48m2 stops
$359American Airlines
Find Deal
Mon, Dec 8 - Sat, Dec 13
United Airlines Logo
10:15 am - 5:50 pmROA-SFO
10h 35m1 stop
United Airlines Logo
11:59 pm - 10:13 amSFO-ROA
7h 14m1 stop
$366United Airlines
Find Deal
Fri, Feb 13 - Mon, Feb 16
United Airlines Logo
10:50 am - 3:35 pmROA-SFO
7h 45m1 stop
United Airlines Logo
11:44 pm - 10:06 amSFO-ROA
7h 22m1 stop
$389United Airlines
Find Deal
Fri, Dec 5 - Mon, Dec 8
American Airlines Logo
6:00 am - 2:55 pmROA-SFO
11h 55m2 stops
American Airlines Logo
1:31 pm - 12:03 amSFO-ROA
7h 32m1 stop
$394American Airlines
Find Deal
Fri, Dec 5 - Sun, Dec 7

American Airlines flights from Roanoke to San Francisco

Our best American Airlines deals on Roanoke to San Francisco flight tickets
American Airlines
Apr 28
ROA3:58 pmRoanoke
9h 54m
1 stop
SFO10:52 pmSan Francisco
May 6
SFO6:15 amSan Francisco
11h 02m
1 stop
ROA8:17 pmRoanoke
$309
Find similar
American Airlines
Apr 23
ROA6:10 pmRoanoke
7h 42m
1 stop
SFO10:52 pmSan Francisco
Apr 27
SFO10:36 pmSan Francisco
6h 53m
1 stop
ROA8:29 amRoanoke
$334
Find similar
American Airlines
Apr 28
ROA3:58 pmRoanoke
9h 34m
2 stops
SFO10:32 pmSan Francisco
May 6
SFO6:15 amSan Francisco
8h 16m
1 stop
ROA5:31 pmRoanoke
$339
Find similar

United Airlines flights from Roanoke to San Francisco

Our best United Airlines deals on Roanoke to San Francisco flight tickets
United Airlines
Dec 8
ROA2:55 pmRoanoke
9h 06m
1 stop
SFO9:01 pmSan Francisco
Dec 13
SFO11:44 pmSan Francisco
7h 22m
1 stop
ROA10:06 amRoanoke
$349
Find similar
United Airlines
Feb 13
ROA10:15 amRoanoke
10h 35m
1 stop
SFO5:50 pmSan Francisco
Feb 16
SFO11:59 pmSan Francisco
7h 14m
1 stop
ROA10:13 amRoanoke
$366
Find similar
United Airlines
Dec 5
ROA10:50 amRoanoke
7h 45m
1 stop
SFO3:35 pmSan Francisco
Dec 8
SFO11:44 pmSan Francisco
7h 22m
1 stop
ROA10:06 amRoanoke
$389
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 23, 2025.
Use the filters below to find and compare flights from Roanoke to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 4/28

3:58 pm-10:52 pm

1 stop9h 54m

San Francisco

Wed 5/6

6:15 am-8:17 pm

1 stop11h 02m

$309

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Thu 4/23

6:10 pm-10:52 pm

1 stop7h 42m

San Francisco

Mon 4/27

10:36 pm-8:29 am

1 stop6h 53m

$334

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 4/28

3:58 pm-10:32 pm

2 stops9h 34m

San Francisco

Wed 5/6

6:15 am-5:31 pm

1 stop8h 16m

$339

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Mon 12/8

2:55 pm-9:01 pm

1 stop9h 06m

San Francisco

Sat 12/13

11:44 pm-10:06 am

1 stop7h 22m

$349

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Mon 12/8

12:58 pm-8:23 pm

2 stops10h 25m

San Francisco

Fri 12/12

12:25 am-10:34 am

1 stop7h 09m

$354

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Wed 2/25

6:00 am-5:56 pm

2 stops14h 56m

San Francisco

Sat 2/28

2:05 pm-12:08 am

1 stop7h 03m

$357

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Mon 12/8

2:03 pm-10:36 pm

2 stops11h 33m

San Francisco

Sat 12/13

10:15 am-12:03 am

2 stops10h 48m

$359

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Fri 2/13

10:15 am-5:50 pm

1 stop10h 35m

San Francisco

Mon 2/16

11:59 pm-10:13 am

1 stop7h 14m

$366

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Fri 12/5

10:50 am-3:35 pm

1 stop7h 45m

San Francisco

Mon 12/8

11:44 pm-10:06 am

1 stop7h 22m

$389

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Fri 12/5

6:00 am-2:55 pm

2 stops11h 55m

San Francisco

Sun 12/7

1:31 pm-12:03 am

1 stop7h 32m

$394

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Roanoke to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of June, then flying in October is also cheap. Prices for this month can be found on momondo for an average of $407.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Roanoke to San Francisco is on a Wednesday when prices can be found for as low as $448. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $722.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Roanoke to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $441. Flights at noon are often more expensive with an average ticket price of $602.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Roanoke when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $518 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Roanoke for as low as $333 on momondo.

How have Roanoke to San Francisco flight prices changed over time?

As of November 2025, prices for Roanoke to San Francisco flights are approximately 58% more expensive when compared to flights at the same time last year.

When to book flights from Roanoke to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to San Francisco (ROA to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to San Francisco

Direct flights

None
There are no direct flights from Roanoke to San Francisco. There are no popular flight routes from Roanoke to San Francisco.
Search flight deals

  • How far is Roanoke to San Francisco by plane?

    A flight from Roanoke to San Francisco will travel around 2305.3 mi. Typically, this will take 7h 42m by plane in normal conditions.

  • When did momondo last update prices for flights from Roanoke Airport to San Francisco Airport?

    Prices for flights from Roanoke Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to San Francisco Airport?

  • How old do you have to be to fly from Roanoke Airport to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Roanoke to San Francisco?

Best airlines flying from Roanoke to San Francisco

Compare and see reviews for airlines that fly from Roanoke to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $282Free CancellationRating
7.9
8,000 reviews
Search Delta flights
United AirlinesPriceFrom $308Free CancellationRating
7.4
9,036 reviews
Search United Airlines flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Calistoga
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Vallejo
Walnut Creek
Half Moon Bay
Salinas
Livermore
Turlock
South San Francisco

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Roanoke to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Roanoke to San Francisco with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Francisco from Roanoke with this policy.

How can momondo help me find flights from Roanoke to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Roanoke. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Roanoke to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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