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Cheap flights from Roanoke to San Francisco from $176

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to San Francisco departing on 2/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Roanoke to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:58 pm - 9:19 pm
ROA
-
SFO
11h 21m1 stop
American Airlines Logo
11:50 am - 11:55 pm
SFO
-
ROA
9h 05m1 stop
$309American Airlines
Tue, Apr 28 - Wed, May 6
American Airlines Logo
7:33 am - 12:56 pm
ROA
-
SFO
8h 23m1 stop
American Airlines Logo
10:36 am - 11:45 pm
SFO
-
ROA
10h 09m2 stops
$314American Airlines
Sat, Feb 21 - Fri, Feb 27
American Airlines Logo
5:00 am - 12:17 pm
ROA
-
SFO
10h 17m1 stop
American Airlines Logo
6:21 am - 5:38 pm
SFO
-
ROA
8h 17m1 stop
$319American Airlines
Thu, Feb 12 - Mon, Feb 16
American Airlines Logo
8:15 am - 4:43 pm
ROA
-
SFO
11h 28m2 stops
American Airlines Logo
10:36 am - 11:45 pm
SFO
-
ROA
10h 09m2 stops
$320American Airlines
Sat, Feb 21 - Fri, Feb 27
American Airlines Logo
11:02 am - 5:53 pm
ROA
-
SFO
9h 51m1 stop
American Airlines Logo
11:30 pm - 11:34 am
SFO
-
ROA
9h 04m2 stops
$324American Airlines
Thu, Feb 12 - Mon, Feb 16
American Airlines Logo
8:15 am - 4:43 pm
ROA
-
SFO
11h 28m2 stops
American Airlines Logo
11:30 pm - 11:34 am
SFO
-
ROA
9h 04m2 stops
$330American Airlines
Thu, Feb 12 - Mon, Feb 16
American Airlines Logo
11:02 am - 5:48 pm
ROA
-
SFO
9h 46m1 stop
American Airlines Logo
12:31 pm - 10:59 pm
SFO
-
ROA
7h 28m1 stop
$349American Airlines
Fri, Feb 20 - Wed, Feb 25
American Airlines Logo
8:09 am - 3:41 pm
ROA
-
SFO
10h 32m2 stops
American Airlines Logo
1:28 pm - 11:55 pm
SFO
-
ROA
7h 27m1 stop
$354American Airlines
Tue, Apr 28 - Wed, May 6
Delta Logo
3:13 pm - 8:33 pm
ROA
-
SFO
8h 20m1 stop
Delta Logo
1:05 pm - 10:27 am
SFO
-
ROA
18h 22m2 stops
$357Delta
Wed, Mar 11 - Tue, Mar 17
American Airlines Logo
1:56 pm - 11:12 pm
ROA
-
SFO
12h 16m2 stops
American Airlines Logo
9:10 am - 10:53 pm
SFO
-
ROA
10h 43m2 stops
$360American Airlines
Thu, Jan 22 - Thu, Jan 29

Delta flights from Roanoke to San Francisco

Our best Delta deals on Roanoke to San Francisco flight tickets
Delta
Mar 11
ROA3:13 pmRoanoke
8h 20m
1 stop
SFO8:33 pmSan Francisco
Mar 17
SFO1:05 pmSan Francisco
18h 22m
2 stops
ROA10:27 amRoanoke
$357
Find similar
Delta
Mar 10
ROA11:10 amRoanoke
9h 26m
1 stop
SFO5:36 pmSan Francisco
Mar 16
SFO9:35 pmSan Francisco
9h 52m
1 stop
ROA10:27 amRoanoke
$384
Find similar
Delta
Mar 10
ROA11:10 amRoanoke
9h 26m
1 stop
SFO5:36 pmSan Francisco
Mar 16
SFO1:05 pmSan Francisco
18h 22m
2 stops
ROA10:27 amRoanoke
$395
Find similar

United Airlines flights from Roanoke to San Francisco

Our best United Airlines deals on Roanoke to San Francisco flight tickets
United Airlines
Mar 8
ROA7:50 pmRoanoke
8h 38m
1 stop
SFO1:28 amSan Francisco
Mar 18
SFO11:20 pmSan Francisco
7h 23m
1 stop
ROA9:43 amRoanoke
$409
Find similar
United Airlines
Mar 8
ROA7:50 pmRoanoke
8h 38m
1 stop
SFO1:28 amSan Francisco
Mar 16
SFO10:50 pmSan Francisco
8h 18m
1 stop
ROA10:08 amRoanoke
$449
Find similar
United Airlines
Jan 20
ROA3:39 pmRoanoke
8h 51m
1 stop
SFO9:30 pmSan Francisco
Jan 24
SFO11:15 pmSan Francisco
9h 50m
1 stop
ROA12:05 pmRoanoke
$489
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 7, 2026.
Use the filters below to find and compare flights from Roanoke to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 4/28

12:58 pm-9:19 pm

1 stop11h 21m

San Francisco

Wed 5/6

11:50 am-11:55 pm

1 stop9h 05m

$309

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Sat 2/21

7:33 am-12:56 pm

1 stop8h 23m

San Francisco

Fri 2/27

10:36 am-11:45 pm

2 stops10h 09m

$314

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Thu 2/12

5:00 am-12:17 pm

1 stop10h 17m

San Francisco

Mon 2/16

6:21 am-5:38 pm

1 stop8h 17m

$319

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Sat 2/21

8:15 am-4:43 pm

2 stops11h 28m

San Francisco

Fri 2/27

10:36 am-11:45 pm

2 stops10h 09m

$320

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Thu 2/12

11:02 am-5:53 pm

1 stop9h 51m

San Francisco

Mon 2/16

11:30 pm-11:34 am

2 stops9h 04m

$324

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Thu 2/12

8:15 am-4:43 pm

2 stops11h 28m

San Francisco

Mon 2/16

11:30 pm-11:34 am

2 stops9h 04m

$330

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Fri 2/20

11:02 am-5:48 pm

1 stop9h 46m

San Francisco

Wed 2/25

12:31 pm-10:59 pm

1 stop7h 28m

$349

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 4/28

8:09 am-3:41 pm

2 stops10h 32m

San Francisco

Wed 5/6

1:28 pm-11:55 pm

1 stop7h 27m

$354

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Wed 3/11

3:13 pm-8:33 pm

1 stop8h 20m

San Francisco

Tue 3/17

1:05 pm-10:27 am

2 stops18h 22m

$357

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Thu 1/22

1:56 pm-11:12 pm

2 stops12h 16m

San Francisco

Thu 1/29

9:10 am-10:53 pm

2 stops10h 43m

$360

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Roanoke to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Roanoke and San Francisco?

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of July, then flying in June is also cheap. Prices for this month can be found on momondo for an average of $406.

How have Roanoke to San Francisco flight prices changed over time?

When to book flights from Roanoke to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to San Francisco (ROA to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to San Francisco

Fastest flight time

8h 18m

Direct flights

None
The fastest flight from Roanoke to San Francisco takes 8h 18m
There are no direct flights from Roanoke to San Francisco. There are no popular flight routes from Roanoke to San Francisco.
Search flight deals

  • How far is Roanoke to San Francisco by plane?

    A flight from Roanoke to San Francisco will travel around 2305.3 mi. Typically, this will take 8h 18m by plane in normal conditions.

  • When did momondo last update prices for flights from Roanoke Airport to San Francisco Airport?

    Prices for flights from Roanoke Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to San Francisco Airport?

  • How old do you have to be to fly from Roanoke Airport to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Roanoke to San Francisco?

Best airlines flying from Roanoke to San Francisco

Compare and see reviews for airlines that fly from Roanoke to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $282Free CancellationRating
7.9
8,022 reviews
Search Delta flights
United AirlinesPriceFrom $308Free CancellationRating
7.4
9,138 reviews
Search United Airlines flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,088 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Hayward
Calistoga
Big Sur
Santa Clara
Berkeley
Walnut Creek
Fremont
Daly City
Half Moon Bay
Vallejo
Livermore
Salinas
Turlock
Sunnyvale

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Roanoke to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Roanoke to San Francisco with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Francisco from Roanoke with this policy.

How can momondo help me find flights from Roanoke to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Roanoke. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Roanoke to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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