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Cheap flights from Roanoke to San Francisco from $171

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to San Francisco departing on 3/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Roanoke to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:58 pm - 9:19 pm
ROA
-
SFO
11h 21m
1 stop
American Airlines Logo
1:16 pm - 11:39 pm
SFO
-
ROA
7h 23m
1 stop
$309American Airlines
Tue, Apr 28 - Wed, May 6
American Airlines Logo
12:58 pm - 9:19 pm
ROA
-
SFO
11h 21m
1 stop
American Airlines Logo
6:45 pm - 8:36 am
SFO
-
ROA
10h 51m
2 stops
$314American Airlines
Tue, Apr 28 - Tue, May 5
American Airlines Logo
7:28 am - 3:25 pm
ROA
-
SFO
10h 57m
2 stops
American Airlines Logo
1:16 pm - 11:39 pm
SFO
-
ROA
7h 23m
1 stop
$320American Airlines
Tue, Apr 28 - Wed, May 6
American Airlines Logo
7:28 am - 3:25 pm
ROA
-
SFO
10h 57m
2 stops
American Airlines Logo
11:28 pm - 12:33 pm
SFO
-
ROA
10h 05m
2 stops
$330American Airlines
Tue, Apr 28 - Tue, May 5
United Airlines Logo
7:50 pm - 1:28 am
ROA
-
SFO
8h 38m
1 stop
United Airlines Logo
11:59 pm - 10:08 am
SFO
-
ROA
7h 09m
1 stop
$347United Airlines
Thu, Mar 12 - Mon, Mar 16
American Airlines Logo
6:00 am - 12:16 pm
ROA
-
SFO
9h 16m
1 stop
American Airlines Logo
8:00 am - 9:26 pm
SFO
-
ROA
10h 26m
2 stops
$354American Airlines
Wed, Apr 22 - Sat, Apr 25
American Airlines Logo
6:30 am - 1:13 pm
ROA
-
SFO
9h 43m
1 stop
American Airlines Logo
11:25 am - 10:59 pm
SFO
-
ROA
8h 34m
1 stop
$359American Airlines
Tue, Jun 9 - Tue, Jun 30
American Airlines Logo
5:18 pm - 11:15 pm
ROA
-
SFO
8h 57m
1 stop
American Airlines Logo
11:28 pm - 12:33 pm
SFO
-
ROA
10h 05m
2 stops
$360American Airlines
Thu, Apr 9 - Tue, Apr 14
American Airlines Logo
7:28 am - 3:25 pm
ROA
-
SFO
10h 57m
2 stops
American Airlines Logo
6:45 pm - 8:36 am
SFO
-
ROA
10h 51m
2 stops
$365American Airlines
Tue, Apr 28 - Tue, May 5
United Airlines Logo
6:15 am - 11:20 am
ROA
-
SFO
8h 05m
1 stop
United Airlines Logo
10:45 pm - 10:12 am
SFO
-
ROA
8h 27m
1 stop
$376United Airlines
Wed, Jun 24 - Mon, Jul 6

Delta flights from Roanoke to San Francisco

Our best Delta deals on Roanoke to San Francisco flight tickets
Delta
Mar 2
ROA3:25 pmRoanoke
9h 15m
1 stop
SFO9:40 pmSan Francisco
Mar 7
SFO2:05 pmSan Francisco
7h 13m
1 stop
ROA12:18 amRoanoke
$439
Delta
Aug 5
ROA6:00 amRoanoke
8h 45m
1 stop
SFO11:45 amSan Francisco
Aug 10
SFO1:45 pmSan Francisco
7h 05m
1 stop
ROA11:50 pmRoanoke
$459
Delta
Mar 5
ROA11:20 amRoanoke
12h 07m
2 stops
SFO8:27 pmSan Francisco
Mar 15
SFO10:40 pmSan Francisco
12h 53m
2 stops
ROA2:33 pmRoanoke
$1,315

American Airlines flights from Roanoke to San Francisco

Our best American Airlines deals on Roanoke to San Francisco flight tickets
American Airlines
Apr 28
ROA12:58 pmRoanoke
9h 13m
1 stop
SFO7:11 pmSan Francisco
May 6
SFO9:08 amSan Francisco
10h 18m
1 stop
ROA10:26 pmRoanoke
$309
American Airlines
Apr 28
ROA12:58 pmRoanoke
11h 21m
1 stop
SFO9:19 pmSan Francisco
May 5
SFO6:45 pmSan Francisco
10h 51m
2 stops
ROA8:36 amRoanoke
$314
American Airlines
Apr 28
ROA7:28 amRoanoke
10h 57m
2 stops
SFO3:25 pmSan Francisco
May 6
SFO1:16 pmSan Francisco
7h 23m
1 stop
ROA11:39 pmRoanoke
$320

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from Roanoke to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 4/28

12:58 pm-9:19 pm

1 stop11h 21m

San Francisco

Wed 5/6

1:16 pm-11:39 pm

1 stop7h 23m

$309

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 4/28

12:58 pm-9:19 pm

1 stop11h 21m

San Francisco

Tue 5/5

6:45 pm-8:36 am

2 stops10h 51m

$314

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 4/28

7:28 am-3:25 pm

2 stops10h 57m

San Francisco

Wed 5/6

1:16 pm-11:39 pm

1 stop7h 23m

$320

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 4/28

7:28 am-3:25 pm

2 stops10h 57m

San Francisco

Tue 5/5

11:28 pm-12:33 pm

2 stops10h 05m

$330

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Thu 3/12

7:50 pm-1:28 am

1 stop8h 38m

San Francisco

Mon 3/16

11:59 pm-10:08 am

1 stop7h 09m

$347

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Wed 4/22

6:00 am-12:16 pm

1 stop9h 16m

San Francisco

Sat 4/25

8:00 am-9:26 pm

2 stops10h 26m

$354

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 6/9

6:30 am-1:13 pm

1 stop9h 43m

San Francisco

Tue 6/30

11:25 am-10:59 pm

1 stop8h 34m

$359

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Thu 4/9

5:18 pm-11:15 pm

1 stop8h 57m

San Francisco

Tue 4/14

11:28 pm-12:33 pm

2 stops10h 05m

$360

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 4/28

7:28 am-3:25 pm

2 stops10h 57m

San Francisco

Tue 5/5

6:45 pm-8:36 am

2 stops10h 51m

$365

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Wed 6/24

6:15 am-11:20 am

1 stop8h 05m

San Francisco

Mon 7/6

10:45 pm-10:12 am

1 stop8h 27m

$376

Flights are sorted by cheapest round-trip flights first.

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See travel insights to San Francisco from

How to get the cheapest flight ticket from Roanoke to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of January, then flying in July is also cheap. Prices for this month can be found on momondo for an average of $383.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Roanoke when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $458 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Roanoke for as low as $363 on momondo.

When to book flights from Roanoke to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to San Francisco (ROA to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to San Francisco

Fastest flight time

7h 44m

Direct flights

None
The fastest flight from Roanoke to San Francisco takes 7h 44m
There are no direct flights from Roanoke to San Francisco. There are no popular flight routes from Roanoke to San Francisco.
Search flight deals

  • How far is Roanoke to San Francisco by plane?

    A flight from Roanoke to San Francisco will travel around 2305.3 mi. Typically, this will take 7h 44m by plane in normal conditions.

  • When did momondo last update prices for flights from Roanoke Airport to San Francisco Airport?

    Prices for flights from Roanoke Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to San Francisco Airport?

  • How old do you have to be to fly from Roanoke Airport to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Roanoke to San Francisco?

Best airlines flying from Roanoke to San Francisco

Compare and see reviews for airlines that fly from Roanoke to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $282Free CancellationRating
7.9
8,241 reviews
Search Delta flights
United AirlinesPriceFrom $308Free CancellationRating
7.4
9,341 reviews
Search United Airlines flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,338 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Walnut Creek
Hayward
Santa Clara
Big Sur
Berkeley
Calistoga
Fremont
Half Moon Bay
Vallejo
Daly City
Salinas
South San Francisco
Milpitas
Sunnyvale

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Roanoke to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Roanoke to San Francisco with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Francisco from Roanoke with this policy.

How can momondo help me find flights from Roanoke to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Roanoke. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Roanoke to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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