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Cheap flights from Roanoke to San Francisco from $175

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to San Francisco departing on 12/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Roanoke to San Francisco

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:33 pm - 11:11 pmROA-SFO
8h 38m1 stop
United Airlines Logo
9:30 pm - 8:34 amSFO-ROA
8h 04m1 stop
$409United Airlines
Find Deal
Tue, Mar 3 - Sat, Mar 7
Delta Logo
7:59 pm - 9:00 amROA-SFO
16h 01m2 stops
Delta Logo
2:05 pm - 12:10 amSFO-ROA
7h 05m1 stop
$451Delta
Find Deal
Tue, Mar 3 - Sat, Mar 7
American Airlines Logo
7:33 am - 5:47 pmROA-SFO
13h 14m2 stops
American Airlines Logo
6:10 am - 5:36 pmSFO-ROA
8h 26m1 stop
$454American Airlines
Find Deal
Tue, Mar 3 - Sat, Mar 7
Delta Logo
6:00 am - 12:30 pmROA-SFO
9h 30m1 stop
Delta Logo
12:30 pm - 12:15 amSFO-ROA
8h 45m1 stop
$456Delta
Find Deal
Thu, Nov 20 - Mon, Nov 24
United Airlines Logo
6:45 am - 1:25 pmROA-SFO
9h 40m1 stop
United Airlines Logo
6:45 am - 6:43 pmSFO-ROA
8h 58m1 stop
$468United Airlines
Find Deal
Thu, Nov 20 - Thu, Nov 27
United Airlines Logo
6:15 am - 9:50 pmROA-SFO
18h 35m1 stop
United Airlines Logo
9:10 pm - 9:57 amSFO-ROA
9h 47m1 stop
$507United Airlines
Find Deal
Sun, Dec 21 - Sat, Dec 27
United Airlines Logo
5:42 pm - 7:20 amROA-SFO
16h 38m2 stops
United Airlines Logo
8:25 am - 8:02 pmSFO-ROA
8h 37m1 stop
$518United Airlines
Find Deal
Fri, Dec 19 - Mon, Jan 19
American Airlines Logo
2:50 pm - 8:20 pmROA-SFO
8h 30m1 stop
American Airlines Logo
12:29 am - 10:39 amSFO-ROA
7h 10m1 stop
$522American Airlines
Find Deal
Tue, Mar 3 - Fri, Mar 6
American Airlines Logo
6:00 am - 2:06 pmROA-SFO
11h 06m1 stop
American Airlines Logo
12:50 am - 2:26 pmSFO-ROA
10h 36m2 stops
$555American Airlines
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Tue, Mar 3 - Fri, Mar 6
American Airlines Logo
6:30 am - 12:30 pmROA-SFO
9h 00m1 stop
American Airlines Logo
10:25 am - 10:54 pmSFO-ROA
9h 29m2 stops
$570American Airlines
Find Deal
Thu, Nov 20 - Mon, Nov 24

American Airlines flights from Roanoke to San Francisco

Our best American Airlines deals on Roanoke to San Francisco flight tickets
American Airlines
Mar 3
ROA7:33 amRoanoke
13h 14m
2 stops
SFO5:47 pmSan Francisco
Mar 7
SFO6:10 amSan Francisco
8h 26m
1 stop
ROA5:36 pmRoanoke
$454
Find similar
American Airlines
Nov 12
ROA12:43 pmRoanoke
10h 47m
1 stop
SFO8:30 pmSan Francisco
Nov 18
SFO11:59 pmSan Francisco
9h 03m
2 stops
ROA12:02 pmRoanoke
$494
Find similar
American Airlines
Nov 12
ROA12:43 pmRoanoke
10h 45m
2 stops
SFO8:28 pmSan Francisco
Nov 18
SFO11:18 pmSan Francisco
9h 44m
2 stops
ROA12:02 pmRoanoke
$499
Find similar

United Airlines flights from Roanoke to San Francisco

Our best United Airlines deals on Roanoke to San Francisco flight tickets
United Airlines
Mar 3
ROA5:33 pmRoanoke
8h 38m
1 stop
SFO11:11 pmSan Francisco
Mar 7
SFO9:30 pmSan Francisco
8h 04m
1 stop
ROA8:34 amRoanoke
$409
Find similar
United Airlines
Nov 20
ROA6:45 amRoanoke
9h 40m
1 stop
SFO1:25 pmSan Francisco
Nov 27
SFO6:45 amSan Francisco
8h 58m
1 stop
ROA6:43 pmRoanoke
$468
Find similar
United Airlines
Nov 12
ROA7:50 pmRoanoke
8h 25m
1 stop
SFO1:15 amSan Francisco
Nov 18
SFO5:10 amSan Francisco
8h 46m
1 stop
ROA4:56 pmRoanoke
$489
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 7, 2025.
Use the filters below to find and compare flights from Roanoke to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 3/3

5:33 pm-11:11 pm

1 stop8h 38m

San Francisco

Sat 3/7

9:30 pm-8:34 am

1 stop8h 04m

$409

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 3/3

7:59 pm-9:00 am

2 stops16h 01m

San Francisco

Sat 3/7

2:05 pm-12:10 am

1 stop7h 05m

$451

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 3/3

7:33 am-5:47 pm

2 stops13h 14m

San Francisco

Sat 3/7

6:10 am-5:36 pm

1 stop8h 26m

$454

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Thu 11/20

6:00 am-12:30 pm

1 stop9h 30m

San Francisco

Mon 11/24

12:30 pm-12:15 am

1 stop8h 45m

$456

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Thu 11/20

6:45 am-1:25 pm

1 stop9h 40m

San Francisco

Thu 11/27

6:45 am-6:43 pm

1 stop8h 58m

$468

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Sun 12/21

6:15 am-9:50 pm

1 stop18h 35m

San Francisco

Sat 12/27

9:10 pm-9:57 am

1 stop9h 47m

$507

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Fri 12/19

5:42 pm-7:20 am

2 stops16h 38m

San Francisco

Mon 1/19

8:25 am-8:02 pm

1 stop8h 37m

$518

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 3/3

2:50 pm-8:20 pm

1 stop8h 30m

San Francisco

Fri 3/6

12:29 am-10:39 am

1 stop7h 10m

$522

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Tue 3/3

6:00 am-2:06 pm

1 stop11h 06m

San Francisco

Fri 3/6

12:50 am-2:26 pm

2 stops10h 36m

$555

RoanokeSan Francisco

ROA - SFO

ROASFO

Roanoke

Thu 11/20

6:30 am-12:30 pm

1 stop9h 00m

San Francisco

Mon 11/24

10:25 am-10:54 pm

2 stops9h 29m

$570

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Roanoke to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to San Francisco?

If you aren’t able to travel to San Francisco during the month of October, then flying in June is also cheap. Prices for this month can be found on momondo for an average of $408.

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart from Roanoke to San Francisco is on a Wednesday when prices can be found for as low as $448. The most expensive day to fly to San Francisco is Monday, with ticket prices averaging around $722.

What is the cheapest time of day to depart on your flight to San Francisco?

Our data shows that the cheapest Roanoke to San Francisco flights are usually those with departure times in the evening. Our users have found flights to San Francisco in the evening for as low as $441. Flights at noon are often more expensive with an average ticket price of $602.

How far in advance should I book a flight to San Francisco?

You are more likely to see cheaper flights to San Francisco from Roanoke when booking weeks ahead of your departure date. In general, you can expect to find flights to San Francisco for around $501 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to San Francisco from Roanoke for as low as $333 on momondo.

How have Roanoke to San Francisco flight prices changed over time?

As of November 2025, prices for Roanoke to San Francisco flights are approximately 51% more expensive when compared to flights at the same time last year.

When to book flights from Roanoke to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to San Francisco (ROA to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to San Francisco

Direct flights

None
There are no direct flights from Roanoke to San Francisco. There are no popular flight routes from Roanoke to San Francisco.
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  • How far is Roanoke to San Francisco by plane?

    A flight from Roanoke to San Francisco will travel around 2305.3 mi. Typically, this will take 7h 50m by plane in normal conditions.

  • When did momondo last update prices for flights from Roanoke Airport to San Francisco Airport?

    Prices for flights from Roanoke Airport to San Francisco Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to San Francisco Airport?

  • How old do you have to be to fly from Roanoke Airport to San Francisco Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The necessary travel and health documents for your San Francisco Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Roanoke to San Francisco?

Best airlines flying from Roanoke to San Francisco

Compare and see reviews for airlines that fly from Roanoke to San Francisco with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $282Free CancellationRating
7.9
8,001 reviews
Search Delta flights
United AirlinesPriceFrom $308Free CancellationRating
7.4
9,007 reviews
Search United Airlines flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
Carmel-by-the-Sea
Modesto
Sonoma
Bodega Bay
Roseville
Calistoga
Hayward
Big Sur
Santa Clara
Daly City
Fremont
Berkeley
Vallejo
Walnut Creek
Half Moon Bay
Salinas
Livermore
Turlock
South San Francisco

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to San Francisco?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Roanoke to San Francisco. momondo saves you time and could save you money on your trip.

Can I find flights from Roanoke to San Francisco with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to San Francisco from Roanoke with this policy.

How can momondo help me find flights from Roanoke to San Francisco?

momondo provides multiple filters to help you find the best flight to San Francisco from Roanoke. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Roanoke to San Francisco right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to San Francisco from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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